20 results about "Biodegradable magnesium" patented technology

The present application provides an orthopedic implant or a component thereof comprising a biodegradable magnesium alloy comprising magnesium and Ca in the range of 0.550 to 0.700 wt%, Zn in the range of 0.400 to 0.700 wt%, and 50 ppm or less Fe, the biodegradable magnesium alloy consisting of two phases comprising a first phase and a second phase having a higher electrochemical activity than the first phase, the first phase comprises magnesium and Zn, and the second phase comprises Mg2Ca precipitates greater than nanoscale. The present application also provides a method of making a biodegradable magnesium alloy, a method of making an orthopedic implant or component thereof, and a method of treating a subject in need of therapy for a medical condition of bone.

This invention provides a method for improving the microstructure and corrosion uniformity of low-temperature extruded magnesium alloys, belonging to the field of magnesium alloy preparation and processing. The method includes the following steps: S1: Cutting a low-alloy element content magnesium alloy ingot and removing the surface oxide layer to obtain a cast sample; S2: Performing pulsed current homogenization treatment on the cast sample; S3: Removing the surface oxide layer from the homogenized alloy to process it into an extrusion billet; S4: Performing low-temperature extrusion treatment on the extrusion billet under pulsed current assistance. This invention improves the microstructure and corrosion uniformity of low-temperature extruded magnesium alloys while ensuring high strength and plasticity, and is suitable for the efficient and energy-saving preparation of biodegradable magnesium alloy extruded bars and sheets.

This application relates to biodegradable magnesium metal composite materials, their preparation methods, and medical devices. The preparation method of the biodegradable magnesium metal composite material includes the following steps: performing a first treatment on the surface of a magnesium metal matrix using an alkali agent to form a magnesium hydroxide passivation layer; performing a second treatment on the magnesium hydroxide passivation layer using phosphorylated amino acids to form a mineralization-inducing layer; and depositing a calcium-phosphorus coating on the surface of the mineralization-inducing layer to prepare the biodegradable magnesium metal composite material. The biodegradable magnesium metal composite material prepared by this method can meet the requirements of long-term corrosion resistance, strong interfacial bonding, and biocompatibility.

The invention relates to a preparation method of a magnesium alloy stent composite coating, and belongs to the technical field of biomedical materials. The composite coating with the piezoelectric-pH synergistic protection function is provided for solving the technical problems that an existing polyester coating is degraded to produce acid, and corrosion of a magnesium alloy stent is accelerated. The coating comprises a PVDF (Polyvinylidene Fluoride)-g-APTES ( The pH regulation and control middle layer is composed of PVDF, PDLLA and alkaline nanoparticles; and a drug-loaded PDLLA outer coating layer. The pH value of the interface is actively increased to a passivation region through on-demand release of the alkaline nanoparticles, and a positive feedback mechanism that protection is achieved when stress is increased is achieved through the piezoelectric effect. Compared with the prior art, the dynamic corrosion resistance is enhanced by 40% or above, the protection effect is improved by 60% or above through the synergistic effect, piezoelectric and alkaline synergistic protection is achieved, and a comprehensive solution with long-acting corrosion resistance and intelligent response is provided for a degradable magnesium alloy implantation instrument.

A biodegradable magnesium metal fixation pin for oral tissue fixation and its preparation method are disclosed. The fixation pin includes a pin head and a pin body. The entire fixation pin is made of 99.9-99.99% high-purity magnesium substrate, with no alloying elements added and an impurity content ≤0.01%. The surface of the fixation pin is sequentially coated with an oxide film layer and a polydopamine / hydroxyapatite composite coating. The oxide film layer has a thickness of 5-15 μm and a porous structure with pore sizes of 1-5 μm. The oxide film layer is prepared by a micro-arc oxidation process. The polydopamine / hydroxyapatite composite coating has a thickness of 10-20 μm, wherein the mass fraction of hydroxyapatite is 30-50%. This biodegradable magnesium metal fixation pin for oral tissue fixation features a reasonable structural design, excellent mechanical properties, and controllable degradation behavior.

The invention relates to the technical field of biological medicine, in particular to biodegradable magnesium sustained-release hydrogel, a preparation method thereof and application of the biodegradable magnesium sustained-release hydrogel in preparation of tumor postoperative adjuvant therapy products. The hydrogel is prepared by taking carboxymethyl chitosan and sodium alginate as matrixes, loading 1.2-9g of metal magnesium powder, mixing, adjusting pH and fumigating and cross-linking with glacial acetic acid, and a three-dimensional network of the hydrogel can realize continuous and controllable release of magnesium ions. According to the invention, the dual functions of promoting wound healing and removing residual tumor cells are realized: magnesium ions are used as healing-promoting enzyme cofactors to accelerate wound repair, and meanwhile, oxidative stress is induced to play an anti-tumor role by disturbing tumor cell iron metabolism; different release rates can be realized by regulating and controlling the loading amount of the magnesium powder, and different tumor postoperative treatment requirements are met. The hydrogel is excellent in biocompatibility, can be completely degraded, is suitable for postoperative adjuvant therapy of solid tumors such as melanoma and breast cancer, can reduce systemic toxic and side effects and tumor drug resistance risks, and is large in clinical transformation potential.

The invention provides a novel biodegradable magnesium-hydroxyapatite-graphene biological material system for an advanced orthopedic implant, and relates to the technical field of implants, and the novel biodegradable magnesium-hydroxyapatite-graphene biological material system for the advanced orthopedic implant comprises magnesium, hydroxyapatite and a graphene nanosheet. Hydroxyapatite and graphene nanosheets are uniformly distributed in a magnesium matrix, and the mechanical property is very close to that of a human skeleton; the mechanical adaptation of magnesium is combined with the osseointegration performance of hydroxyapatite and the strengthening and corrosion resistance of the graphene nanosheets, the orthopedic implant is naturally integrated in vivo and can be gradually decomposed and completely degraded in vivo, the problem that traditional non-degradable materials (such as titanium or stainless steel) need to be taken out through a secondary operation is solved, the graphene nanosheets inhibit pitting corrosion, and the mechanical property of the orthopedic implant is improved. The corrosion rate is reduced by about 50%, the orthopedic implant has corrosion resistance, the service life of the implant is prolonged, and hydroxyapatite promotes bone growth and accelerates bone healing.

The invention discloses a degradable magnesium alloy intravascular stent based on bionic hydrogel and nitric oxide double-path release and a preparation method and application thereof. The method comprises the steps that a magnesium alloy base material is subjected to alkali heat treatment; immersing the treated magnesium alloy into a silane coupling agent for reaction; the photopolymerization reaction liquid is treated to the surface of the silanization modified magnesium alloy, and polymerization is conducted through ultraviolet irradiation; immersing the magnesium alloy with the hydrogel coating into a polyarginine solution, and grafting polyarginine onto the surface of the hydrogel; a sample is activated through EDC / NHS and then immersed in a selenocystamine solution for a reaction, and the bionic composite coating, with the exogenous / endogenous dual-path nitric oxide release function, of the degradable magnesium alloy intravascular stent is obtained. The invention successfully constructs the bionic coating integrating cell membrane-imitating anti-fouling and exogenous / endogenous dual-path NO release functions, and the coating effectively solves the key problems of corrosion control, thrombus formation resistance, functional re-endothelialization coordinated regulation and the like faced by the degradable magnesium alloy intravascular stent.

This invention discloses a method for preparing a biodegradable magnesium metal hernia repair patch and a patch implantation system, belonging to the field of patch technology. The method for preparing the biodegradable magnesium metal hernia repair patch includes: using a magnesium plate as the base material, with a mesh size of 0-70%, and the outer contour of the patch having wavy edges or rounded corners; the thickness of the biodegradable magnesium metal hernia repair patch being 0.05mm to 0.5mm; selecting a magnesium alloy ingot as the base material, and extruding and rolling the base material into an ingot plate of a predetermined size; annealing the ingot plate in an annealing furnace at 180°C for 1-2 hours, removing it, and leveling it to form a magnesium plate; processing the mesh and outer contour on the magnesium plate using cutting or stamping equipment to form a prototype patch; polishing, cleaning, packaging, and sterilizing the prototype patch to obtain the biodegradable magnesium metal hernia repair patch, which is not only absorbable by the human body but also has low plasticity and hardness, making it easy to store and implant in the body.

This invention belongs to the field of medical materials technology, specifically relating to a bioresorbable corrosion-resistant magnesium alloy cardiovascular stent and its preparation method. This invention, through multi-element microalloying design, introduces specific types and amounts of alloying elements (such as Zn, Ca, Sr, Mn, and Nd) to synergistically regulate the electrode potential and microstructure of the alloy while ensuring biocompatibility. It also provides matching precision plastic processing and post-processing techniques. Through grain refinement, texture optimization, and surface modification, excellent radial support strength is achieved while simultaneously realizing controllable degradation rate and uniform degradation pattern. The results of the embodiments show that the corrosion reaction of the magnesium alloy cardiovascular stent of this invention occurs uniformly, solving the key problem of uniform degradation of biodegradable magnesium alloy stents.

The utility model relates to the technical field of bone fixing plates, and particularly discloses a bone fixing plate with double effects of promoting osteogenesis and gradient degradation. The bone fixing plate comprises a first high polymer material layer, a first biodegradable magnesium alloy layer, a second high polymer material layer, a biodegradable zinc alloy layer, a third high polymer material layer, a second biodegradable magnesium alloy layer and a fourth high polymer material layer which are sequentially stacked. The bone fixing plate with the double effects of promoting osteogenesis and gradient degradation, provided by the utility model, has remarkable advantages in mechanical property, degradation effect and osteogenesis promoting effect.

This invention discloses a processing device for biodegradable magnesium alloy vascular stents, comprising a processing device body, tracks, a controller, and a transmission mechanism. The processing device body includes a polishing tank, a sandblasting tank, and a cleaning tank. Multiple transmission mechanisms are arranged between the tracks. Each transmission mechanism includes a transmission rod, a drive mechanism, and multiple positioning mechanisms. Rollers are provided at both ends of the transmission rod, and multiple racks and air holes are provided on the surface of the transmission rod. The drive mechanism includes a servo motor, a sub-control unit, and a transmission gear. The two ends of the transmission gear mesh with the servo motor and the rack, respectively. Each positioning mechanism includes a drive shaft and a cannula. The surface of the drive shaft meshes with the rack, and the cannula is rotatably inserted into the drive shaft. This invention enables continuous and batch sandblasting and electrochemical polishing of vascular stents, which not only improves production efficiency but also helps to reduce the production cost of vascular stents.

The present invention relates to a biodegradable alloy of Formula (I): Mg—Zn—X, wherein X represents —Ca—Mn or —Dy—Sr, wherein Zn is about 0.1 wt % to about 3.0 wt %, Dy is about 0.1 wt % to about 0.7 wt %, Sr is about 0.1 wt % to about 0.9 wt %, Ca is about 0.1 wt % to about 1.5 wt %, Mn is about 0.1 wt % to about 0.9 wt % and Mg is balance with impurities. The present invention further relates to a method for producing alloys, wherein the method comprises: (a) placing alloy components in a crucible, wherein the alloy components are placed in the crucible in a multilayer arrangement; (b) melting the alloy components at about 700° C. to about 850° C.; (c) stirring the melt of step (b) at about 400 rpm to about 500 rpm; (d) atomizing the melt of step (c) into millimeter size droplets using jets of inert gas; and (e) cooling and depositing the atomized alloy melt to obtain an ingot.

The application discloses a collagen anticorrosion coating with tissue repair performance, a preparation method and application, and belongs to the technical field of medical coatings. The application designs a novel self-repairing anticorrosion coating, and collagen is loaded on the coating through an excipient, so that the anticorrosion protection and biological function of the collagen anticorrosion coating are deeply integrated. The prepared collagen anticorrosion coating is firmly combined with a magnesium alloy substrate through a covalent bond, and no cracking and falling-off phenomenon occurs after being implanted in vivo for 4 weeks, the scaffold structure has good integrity, can provide sustained radial support, provides a sufficient time window for blood vessel repair, and provides a feasible scheme for clinical transformation of a new generation of biodegradable magnesium-based blood vessel stents.

This invention discloses a collagen-based anti-corrosion coating with tissue repair properties, its preparation method, and its applications, belonging to the field of medical coating technology. This invention designs a novel self-healing anti-corrosion coating and loads collagen onto the coating using excipients, achieving a deep integration of anti-corrosion protection and biological function. The prepared collagen-based anti-corrosion coating is firmly bonded to a magnesium alloy substrate via covalent bonds. After 4 weeks of in vivo implantation, no cracking or detachment was observed, the stent structure maintained good integrity, and it provides continuous radial support, offering sufficient time for vascular repair. This provides a feasible solution for the clinical translation of next-generation biodegradable magnesium-based vascular stents.

The invention relates to a degradable magnesium alloy medical implant as well as a preparation method and application thereof. The degradable magnesium alloy medical implant structurally comprises a magnesium alloy matrix, a middle layer, an oxide passivation layer and a polydopamine layer in sequence from inside to outside, the material is prepared through a laser powder bed melting 3D printing process, and has a customized macroscopic appearance and a porous structure matched with the bone defect form. According to the magnesium alloy medical implant provided by the invention, an oxide passivation layer-polydopamine layer composite protection system is constructed, so that an effective barrier is formed on a physical level, and direct erosion of a body fluid environment to a magnesium alloy matrix is remarkably reduced. By means of the composite structure, the degradation rate of the implant is accurately controlled, it is guaranteed that the degradation period of the implant is synchronous with the natural process of human bone tissue reconstruction and function recovery, and a stable mechanical supporting environment is provided for bone defect repair.

The invention belongs to the field of oil and gas field underground tool manufacturing, and particularly relates to a corrugated piece for a degradable magnesium alloy bridge plug and a rolling preparation method, and the rolling preparation method comprises the steps of rolling equipment preparation and pretreatment, raw material pretreatment, special-shaped asynchronous hot rolling forming, stress relief annealing and finishing. According to the method, multi-pass asynchronous hole pattern rolling is carried out on the difficult-to-deform degradable magnesium alloy blank, and a strong cross shear field is introduced into a deformation area by utilizing the linear velocity difference of the lower concave roller and the upper concave roller, so that the plastic flowing capacity of the magnesium alloy is greatly improved, complex corrugated hole patterns can be accurately filled, and near-net forming is realized; and while a complete metal fiber flow line distributed in a tooth shape is reserved, coarse second-phase particles are effectively broken, non-basal plane slippage and sufficient dynamic recrystallization are induced, and therefore the basal plane texture is weakened. Finally, on the premise that the material utilization rate is greatly increased, collaborative improvement of the shear strength, the structural integrity and the uniform degradation performance of the corrugated piece is achieved.

The invention relates to biodegradable, magnesium alloys, compositions and composites, methods for their preparation and applications for their use as implantable medical devices in load-bearing conditions. The magnesium alloys are composed of alloying elements selected from yttrium, calcium, zirconium, zinc, and strontium, with the remainder being magnesium and impurities arising due to production, and preparation of the alloy by melting together the elements and casting the resulting melted mixture. In certain embodiments, the methods of preparation include solution treatment and hot extrusion.

A Mg-Nd-Gd-Zn-Sm biodegradable magnesium alloy and its preparation method are disclosed. The magnesium alloy has the following composition by mass percentage: Nd: 2.4-3.0%, Gd: 1.2-2.0%, Zn: 1.0-1.5%, Sm: 0.5-1.0%, other unavoidable impurities ≤0.1%, and the remainder being Mg. Preparation steps: Pure magnesium, Mg-Nd master alloy, Mg-Gd master alloy, Mg-Zn master alloy, and Mg-Sm master alloy are used as raw materials for batching and drying before smelting; pure magnesium is placed in a medium-frequency induction furnace and filled with protective gas; heated to 670℃~800℃ until the magnesium ingot is completely melted; the temperature is raised to 800~900℃, other raw materials are added, and after complete melting, the temperature is held for 30~60 minutes; the temperature is lowered to 800℃~820℃, refining agent is added, and after refining, it is allowed to stand for 30~50 minutes; the temperature is lowered to 750℃~790℃, and the ingot is cast and cooled to obtain a magnesium alloy ingot; annealing and homogenization are performed; extrusion treatment is then carried out. The biodegradable magnesium alloy of this invention has good mechanical properties and corrosion resistance, the degradation rate is controllable and it is harmless to the human body, and the preparation process is simple and low in cost.

The present application provides a biodegradable magnesium alloy without rare earth elements. The magnesium alloy comprises the following elements in percentage by mass: Zn 1.0-5.0%; Mn 0.1-1.0%; Ca 0.1-1.0%; Sr 0.1-1.0%; Sn 0.1-3.0%; Zr 0.1-0.8%; and Mg balance. The impurity in the magnesium alloy does not contain rare earth elements. The present application also provides a method for preparing the above biodegradable magnesium alloy and use in the preparation of medical devices. In the present application, Mg is used as the main components and mixed with a specific proportion of Zn, Ca and Mn to prepare the alloy. The biodegradable magnesium alloy of the present application has a controllable degradation rate and strong mechanical strength, and there are no harmful elements to a human body, and the degradation of the alloy in the human body will not affect human body.