A kind of preparation method of degradable magnesium alloy implant material

A magnesium alloy and implant technology, which is applied in the field of preparation of degradable implant materials, can solve the problems of poor electrolyte stability, too fast coating degradation, low biological activity, etc., and achieves improved biological activity and high bonding strength. , the effect of promoting bone tissue growth

Active Publication Date: 2011-12-07
SHANDONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Implant materials prepared by the existing micro-arc oxidation technology generally have problems such as poor electrolyte stability, lo

Method used

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  • A kind of preparation method of degradable magnesium alloy implant material
  • A kind of preparation method of degradable magnesium alloy implant material
  • A kind of preparation method of degradable magnesium alloy implant material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 The preparation method of degradable magnesium alloy implant material

[0045] Proceed as follows:

[0046] (1) Preparation of electrolyte: add (CH 3 COO) 2 Ca as a calcium source, and adding Na 2 HPO 4 , (NaPO 3 ) 6 、Na 3 PO 4 or CaHPO 4 As a phosphorus additive, an electrolyte containing calcium and phosphorus salts is prepared.

[0047] The basic electrolyte is composed of deionized water, KOH, NH 4 HF 2 、C 3 h 8 o 3 and H 2 o 2 Prepared, wherein, the concentration of KOH is 0.0891mol / L, NH 4 HF 2 The concentration is 0.1227mol / L, C 3 h 8 o 3 The volume fraction is 0.5%, H 2 o 2 The volume fraction is 1.5%. The calcium source in the electrolyte used in each group of samples (CH 3 COO) 2 Ca and phosphorus additive Na 2 HPO 4 , (NaPO 3 ) 6 、Na 3 PO 4 or CaHPO 4 The specific content of is shown in Table 1-1;

[0048] (2) Preparation of base material: using ZK60 magnesium alloy as the base material, the plate-shaped material ...

Embodiment 2

[0064] Embodiment 2 The preparation method of degradable magnesium alloy implant material

[0065] Proceed as follows:

[0066] (1) Preparation of electrolyte: add (CH 3 COO) 2 Ca as a calcium source with addition of CaHPO 4 As phosphorus additive, NH 4 HF 2 and C 3 h 8 o 3 , to prepare electrolytes containing calcium and phosphate salts. where (CH 3 COO) 2 The concentration of Ca is 0.010mol / L, CaHPO 4 The concentration is 0.005mol / L, NH 4 HF 2 The concentration is 0.1227mol / L, C 3 h 8 o 3 The volume fraction is 0.5%;

[0067] (2) Preparation of base material: using ZK60 magnesium alloy as the base material, the plate-shaped material is divided into 8×10×12mm by wire cutting 3 Drill holes and tap threads on the small surface of the cuboid to facilitate clamping during the micro-arc oxidation test; grind on sandpaper of different thicknesses, and the last sandpaper is 1000 # , use acetone to remove the grease on the surface of the magnesium alloy, then ultras...

Embodiment 3

[0084] Embodiment 3 The preparation method of degradable magnesium alloy implant material

[0085] Proceed as follows:

[0086] (1) Preparation of electrolyte: add (CH 3 COO) 2 Ca as a calcium source with addition of CaHPO 4 As a phosphorus additive, an electrolyte containing calcium and phosphorus salts is prepared. where (CH 3 COO) 2 The concentration of Ca is 0.010mol / L, CaHPO 4 The concentration is 0.005mol / L, NH 4 HF 2 The concentration is 0.1227mol / L, C 3 h 8 o 3 The volume fraction is 0.5%;

[0087] (2) Preparation of base material: using ZK60 magnesium alloy as the base material, the plate-shaped material is divided into 8×10×12mm by wire cutting 3 Drill holes and tap threads on the small surface of the cuboid to facilitate clamping during the micro-arc oxidation test; grind on sandpaper of different thicknesses, and the last sandpaper is 1000 # , use acetone to remove the grease on the surface of the magnesium alloy, then ultrasonically clean it in alcoho...

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Abstract

The invention relates to a method for preparing a degradable magnesium alloy implant material. In the method, (CH3COO)2Ca is added into a base electrolyte to serve as a calcium source, and a phosphate is also added in the base electrolyte to serve as a phosphorus additive to prepare an electrolyte; a magnesium alloy is placed in the electrolyte to serve as an anode; a microarc oxidation power supply is used for supplying electricity, wherein the power supply frequency range is 400-600Hz, the positive duty ratio is 30-50%, the negative duty ratio is 10-30%, and the ratio of the number of the positive pulses to the number of the negative pulses is 1:1; and the degradable magnesium alloy implant material is obtained through electrified reaction under a constant pressure or constant power mode. The implant prepared by the method in the invention has a surface composed of a loose layer and a compact layer, the loose layer surface is distributed with multiple micropores, and the compact layer is in good metallurgic bonding with a basal body so as to ensure a coating to have high hardness, compactness and cohesion as well as good resistance to wear and corrosion; and at the same time, mice acute toxicity tests prove that the coating has good biocompatibility, and simulated body fluid (SBF) soaking tests prove that the coating has good bioactivity, thus the degradable implant materialhas a wide prospect.

Description

technical field [0001] The invention relates to a preparation method of a degradable implant material. Background technique [0002] As we all know, stainless steel, titanium and cobalt-based alloys have been widely used clinically as implant materials, but the density and elastic modulus of medical stainless steel are quite different from those of human hard tissues, resulting in poor mechanical compatibility. Cobalt-based alloys have excellent mechanical properties, good biocompatibility, and excellent corrosion resistance, wear resistance and casting properties; however, artificial joints made of cast cobalt-based alloys have a high loosening rate in the body, and cobalt, nickel, Chromium may also produce skin allergic reactions, among which cobalt is the most serious, so its wide application also has certain limitations. The wear debris generated by titanium-based medical alloys during service dissociates near the implant, which is likely to cause inflammation, and its ...

Claims

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Application Information

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IPC IPC(8): C25D11/30C25D11/36C25D9/06
Inventor 陈传忠于雪潘尧坤于慧君王佃刚
Owner SHANDONG UNIV
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