8 results about "Acute toxicity" patented technology

The invention discloses a liver protection composition containing glutathione-rich yeast. The liver protection composition is prepared from the glutathione-rich yeast, turmeric, silybum marianum, enzymolysis polypeptide with homology of medicine and food and anti-inflammatory and anti-oxidation auxiliary components. Wherein the medicine and food homologous enzymolysis polypeptide is prepared from radix puerariae through neutral protease-cellulase double enzymolysis, the polypeptide sequence is identified as Leuu-Val-Glu-Pro-Ala, and the medicine and food homologous enzymolysis polypeptide has the capacity of remarkably inhibiting LPS-induced RAW264.7 cell NO release and removing DPPH free radicals. According to the composition, through multi-component synergism, in an anti-alcohol experiment, the blood alcohol concentration decline rate of a mouse can be remarkably increased, the MDA content of liver tissue is remarkably reduced, and no acute toxic reaction exists. The composition has the functions of protecting the liver and dispelling the effects of alcohol, is safe and effective, and is suitable for the field of health-care products or functional foods.

Provided are use of a bioactive protein in the preparation of a drug for treating herpes virus infection and a pharmaceutical composition for treating herpes virus infection. The pharmaceutical composition mainly comprises a bioactive protein, a matrix, a humectant, a pH regulator, and a preservative. The present invention has the following technical effects: 1) By means of a large amount of research and experimental verification, the inventors have discovered for the first time that anhydridized lactoferrin, a modified bioactive protein, has an inhibitory effect on herpes zoster virus (VZV). 2) In the pharmaceutical composition, the type and amount of excipient and the proportion of the main ingredient are reasonable. The pharmaceutical composition is administered in ointment form, in spray form, or in other dosage forms suitable for external use, has a significant therapeutic effect, has small local toxic side effects, has very low acute dermal toxicity, causes no irritation or allergy, does not interfere with normal skin functions, and is safe and effective.

The invention relates to a double-drug liposome co-carrying oxymatrine and an STING agonist prodrug as well as a preparation method and application of the double-drug liposome. The double-drug liposome comprises a drug carrier and oxymatrine, wherein the drug carrier consists of a membrane material; the oxymatrine is loaded in a hydrophilic inner cavity of the carrier; the membrane material is prepared from distearoyl phosphatidylcholine, distearoyl phosphatidyl ethanolamine-polyethylene glycol and a cholesterol-STING agonist prodrug conjugate; the cholesterol-STING agonist prodrug conjugate is a conjugate formed by coupling an STING agonist prodrug with cholesterol through a chemical bond. According to the invention, the traditional Chinese medicine active component oxymatrine and the STING agonist prodrug are creatively integrated into the same liposome, so that synergistic controlled release and mechanism complementation can be realized; wherein the STING prodrug is embedded into the carrier in a chemical bond coupling manner, so that drug leakage caused by physical entrapment is avoided, the acute toxicity of the free STING agonist is remarkably reduced, and meanwhile, the innate immune activation capability of the free STING agonist is enhanced.

The invention relates to a Tibetan medicine compound preparation for relieving stomach discomfort and protecting gastric mucosa. The Tibetan medicine compound preparation is prepared from 11 medicinal materials including gypsum rubrum (prepared), safflower carthamus, liquorice and the like through a special process. The core innovation is as follows: gypsum rubrum is processed by co-melting borax, potassium nitrate and aconite, a high-dissolution-rate calcium-boron compound is generated, and the toxicity is reduced; the highland barley wine and the yellow milk cooperate to form a gastric mucosa protective film. The medicinal materials are subjected to dynamic three-stage ultrasonic extraction (300 W to 200 W to 200 W) to realize graded dissolution of fat-soluble and heat-sensitive components, and the purity of the effective components reaches 98% in combination with a membrane filtration system (5 mu m to 0.45 mu m to 0.2 mu m). According to the compound, three-axis synergy of acid-relieving and pain-relieving (the pH value is increased to 3.5-4.0 in 30 minutes), blood-activating and film-protecting (the DPPH clearance rate is 89%) and qi-regulating and distention-eliminating (the helicobacter pylori MIC value is 0.5 mg / mL) is adopted, and nitrogen-filled packaging (the stability is 18 months) and palatability optimization (the compliance is 92%) are adopted as auxiliary materials. The acute toxicity LD50 is greater than 5g / kg, the long-term toxicity does not cause liver and kidney injury, the bottleneck of side effects of western medicines is broken through, and the traditional Chinese medicine is suitable for health care and adjuvant therapy of stomachache, sour regurgitation and other symptoms.

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for controlling obesity. The traditional Chinese medicine composition comprises Pueraria pedunculata, Lantana camara, Curcuma longa, Curcuma wenyujin, Curcuma roxburghii, Angelica sinensis, Boswellia carterii, Commiphora myrrha, Semen Persicae, Radix Polygoni multiflori and Rubus corchorifolius. The traditional Chinese medicine composition can effectively regulate blood fat by external use, thereby achieving the effects of improving obesity-related metabolic disorders and controlling obesity. In addition, the traditional Chinese medicine composition has no skin irritation when used externally, and has no acute toxicity at a dosage much higher than a clinical dosage, and is safe and reliable to use, and has a wide application prospect in controlling obesity.

The present application relates to a kind of plant lactobacillus rhamnosus for relieving anxiety, tranquilizing sleep aid and its composition in solid beverage, the preservation number of the plant lactobacillus rhamnosus is CGMCC No.30265, it is isolated from traditional yogurt, it is strong in safety, no pathogenicity, without acute toxicity;And after culture screening, it is verified by experiment, combined with plant extract, promote the production of 5-hydroxytryptamine, enhance the effect of relieving anxiety, tranquilizing sleep aid.The present application also provides a kind of probiotic solid beverage for tranquilizing sleep aid, it can promote the rapid and efficient planting of plant lactobacillus rhamnosus by adding prebiotic combination, while adding plant extract combination, synergistic effect with probiotic, greatly enhance the effect of relieving anxiety, tranquilizing sleep aid.The composition component is safe, nontoxic and harmless, tranquilizing sleep aid effect is remarkable, with broad market prospect.

The invention provides an anti-adenovirus disinfection composition as well as a preparation method and application thereof, and belongs to the technical field of disinfectants. Effective components of the anti-adenovirus disinfection composition are prepared from the following raw materials in parts by weight: 5-15 parts of folium artemisiae argyi, 8-18 parts of quassia, 5-10 parts of subprostrate sophora and 5-10 parts of cynanchum paniculatum. The disinfection composition has no acute toxicity to skin, has broad-spectrum bacteriostasis and efficient anti-adenovirus, and can be used for daily infection prevention and disinfection.

The invention discloses a traditional Chinese medicine mask for treating cyst nodule type acne and a preparation method thereof. The traditional Chinese medicine mask is prepared from the following components in percentage by mass: 10% of traditional Chinese medicine potato powder and 90% of mask matrix. Wherein the traditional Chinese medicine powder comprises potatoes, radix ranunculi ternati, radix angelicae, spina gleditsiae, raw radix astragali, raw liquorice and borneol, and the mask matrix comprises kaolin, glycerol, bentonite and the like. The preparation method comprises the following steps: drying the traditional Chinese medicinal materials at low temperature, crushing, sieving, mixing with the borneol by adopting an equivalent incremental method, performing Co-60 irradiation disinfection, and mixing with the mask matrix to prepare a finished product. Animal experiments prove that the mask has a remarkable treatment effect on an experimental acne model and can effectively relieve local inflammation and promote skin lesion healing, acute toxicity and skin irritation tests show that the mask is good in safety, and a natural, safe and effective external treatment choice is provided for cyst nodule type acne.