Clathrate compound containing ginsenoside Rg2 and method of preparing the same

A technology of ginsenosides and inclusion compounds, which is applied to medical preparations containing active ingredients, non-active ingredients of polymer compounds, and pharmaceutical formulations, etc. It can solve problems such as poor solubility and difficulty in preparing injections

CN101138545AInactive Publication Date: 2008-03-12GUANGZHOU TIANAN MEDICAL TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2008-03-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses an inclusion complex containing the panaxsaponin Rg2 and the preparation method. The inclusion complex of the invention consists of the panaxsaponin Rg2 and the hydroxypropyl-Beta-cyclodextrin. The preparation method of the present invention is as following. The hydroxypropyl-Beta-cyclodextrin water solution is prepared; the hydroxypropyl-Beta-cyclodextrin solution is kept in the water bath; the extraction powder of the panaxsaponin Rg2 or the extraction of the liquid-typed Rg2 dissoluted by the solvent is added before mixing and complex; therefore the liquid inclusion complex is obtained and the inclusion complex after drying. The inclusion complex of the present invention has functions of increasing the heart perfusion and the blood flow, expanding the diameter of the vein and the artery, improving the microcirculation disturbance, improving the myocardial ischemia and anti-thrombosis effect. The present invention can significantly reduce the acute toxicity of the panaxsaponin Rg2.
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Description

technical field

[0001] The invention relates to a drug inclusion compound and its quality control method, in particular to a compound containing ginsenoside Rg 2 clathrate and its quality control method. Background technique

[0002] There are many kinds of ginsenosides in ginseng, and there are more than 30 kinds of ingredients that have been clearly identified, among which ginsenoside Rg 2 (Ginsegnoside Rg 2 ) is a known compound that was isolated in the early years. Before the 1990s, the medical use of this compound was not clear, so it was not developed and applied. Studies have shown that the compound has two isomers of ginsenoside C-20(S) and C-20(R), but the compound has poor solubility in water and is difficult to prepare injections.

[0003] The inventor applied for "Ginsenoside Rg" in 2000 2 Invention patent (Chinese patent ZL01102117.9) for the application in the preparation of drugs for cardiovascular and cerebrovascular diseases, followed by the application...

Examples

Embodiment 1

[0166] Embodiment 1: Get ginsenoside Rg 2 15kg of extract, 50kg of hydroxypropyl-β-cyclodextrin, made into capsules according to conventional technology, 0.45g per capsule.

Embodiment 2

[0167] Embodiment 2: Get ginsenoside Rg 2 Extract 11kg, hydroxypropyl-β-cyclodextrin 62kg, made into tablets according to the conventional process, each tablet 0.45g.

Embodiment 3

[0168] Embodiment 3: Get ginsenoside Rg 2 Extract 18kg, hydroxypropyl-β-cyclodextrin 46kg, make oral solution according to conventional technology, each 10ml.