26 results about "Microcirculation disorders" patented technology

The invention relates to the technical field of medical instruments, in particular to a heart health state assessment method, a processing device, a system and a computer readable storage medium. Motion electrocardiogram data, resting electrocardiogram data and conventional electrocardiogram data output by electrocardiogram leads are obtained and analyzed to determine the possibility of myocardial ischemia, coronary artery lesion, myocardial bridge and coronary microcirculation disturbance, and the heart health state is qualitatively evaluated according to the determination result. And under the condition that the possibility of myocardial ischemia and / or coronary artery lesion exists is determined, quantitative evaluation is carried out on myocardial ischemia and / or coronary artery lesion, and finally the heart health state is evaluated according to the qualitative evaluation result and the quantitative evaluation result. According to the technical scheme provided by the embodiment of the invention, the heart health state can be more accurately qualitatively and quantitatively analyzed by combining the exercise electrocardio data, the resting electrocardio data and the conventional ECG data.

The invention discloses a construction method of a coronary artery microcirculation disturbance cell model, and belongs to the technical field of biological medicine. According to the method, mouse heart microvascular endothelial cells (MCMEC) are taken as objects, tetrachlorohydroquinone (TCHQ) is used for treating for 6 hours at the concentration of 20-40 [mu] M, and CMD typical characteristics such as apoptosis, increase of reactive oxygen species (ROS), reduction of nitric oxide (NO) and release of inflammatory factors (TNF-alpha and IL-1beta) of the cells are induced. The TCHQ is applied to construction of the CMD model for the first time, and the model is stable, good in repeatability and capable of being used for CMD pathogenesis research and drug screening.

This invention discloses a traditional Chinese medicine composition for improving hypertension, belonging to the field of traditional Chinese medicine compound preparation technology. This invention targets the core pathogenesis of hypertension caused by phlegm-dampness obstruction and peripheral microcirculation disorders, leading to abnormal activation of the hypothalamic-sympathetic-cardiac axis and compensatory cardiac hypertensive. The treatment principle is to resolve phlegm and dampness, and invigorate blood circulation. It is formulated with nutmeg, allium macrostemon, amomum villosum, peach kernel, safflower, platycodon grandiflorus, angelica dahurica, and tangerine peel. This combination can dredge the meridians, improve peripheral blood supply, and alleviate cardiac compensatory pumping, thus addressing hypertension caused by phlegm-dampness obstruction at its root. The formula is scientifically formulated, highly safe, and easy to prepare, making it suitable for long-term treatment and industrial promotion.

The invention belongs to the technical field of burn wound analysis. According to the skin burn analysis method and system based on contrast agent blood perfusion, firstly, a fluorescence sequence after a contrast agent is injected is obtained, and a preprocessing sequence is generated through area cutting and down-sampling; a fluorescence intensity time curve of each pixel point is extracted, peak time is determined, and statistics is carried out to construct a peak time histogram; performing smooth denoising, extreme value detection and weak peak removal on the histogram, and adaptively selecting a threshold value for distinguishing normal and burnt tissues; generating an initial mask by using the threshold value, and performing connected domain analysis and morphological post-processing to obtain a target burn area mask; and finally, generating a pseudo-color image in combination with peak time. According to the method, the time dynamic characteristic of blood perfusion is fully utilized, the burn area can be accurately segmented and the microcirculation disturbance degree can be visually presented without depending on skin textures or a large amount of training data, and the objectivity and accuracy of burn depth evaluation are remarkably improved.

The invention discloses a preparation method of a coronary artery microcirculation disturbance animal model, and belongs to the technical field of biological medicine. According to the method, the stable mouse CMD model can be established by injecting 20-40 [mu] g / mL Calcimycin into the cardiac apex for the first time. Calcimycin is a calcium ion (Ca < 2 + >) carrier commonly used in a laboratory and can transport calcium ions outside cells into the cells, so that the concentration of the calcium ions in the cells is increased. Particularly, when 40 [mu] g / mL of Calcimycin is injected, the pathological severity of the Calcimycin is further aggravated, myocardial fiber arrangement is disordered, boundary is unclear, a large number of myocardial cells are necrotic and dissolved, cavitation is formed, vascular wall degeneration swelling is caused, inflammatory cell infiltration is caused, and thrombus is formed in microvessels.

The application provides a candidate drug for promoting embryo implantation efficiency of a patient with endometrial microcirculation disorder type RIF, and belongs to the technical field of embryo implantation. In order to solve the problem of how to find a potential intervention drug for the pathological mechanism of microcirculation disorder type RIF, a five-step high-efficiency drug screening strategy based on an in-vitro implantation model of endometrial microcirculation disorder type repeated embryo implantation failure is adopted to ensure the reliability and functional correlation of the screening result. The candidate drug screened by the five-step high-efficiency drug screening strategy includes any one of the following drugs: phenylbutazone, ferulic acid, L-proline, indinavir, solfazone, teneligliptin and gemcitabine. Among the candidate drugs, phenylbutazone, ferulic acid and L-proline are the best three drugs for promoting the implantation efficiency of the patient with endometrial microcirculation disorder type RIF.

The invention discloses a single-stage negative oxygen ion flow device for purifying blood cells, which belongs to the technical field of electrotherapy, negative ion therapy and blood purification, and comprises a single-stage negative oxygen ion generation and targeted guide and grounding loop. According to the device, a high-purity negative oxygen ion flow with the particle size smaller than 0.01 mu m is generated through a single-stage negative high voltage and double shielding technology and enters a human body through skin / respiratory tract double paths, a device-human body-ground closed charge circulation loop is constructed, deep purification of blood cells is achieved through quadruple mechanisms such as cell membrane potential repair, and the purpose of purifying the blood cells is achieved. The device is suitable for household blood health care and auxiliary treatment of hyperviscosity and microcirculation disturbance of medical institutions, solves the problems of low ion purity, poor penetrability, target deficiency and the like of traditional equipment, and is high in safety and remarkable in purification effect.

The invention discloses a special diet for improving cardiovascular and cerebrovascular diseases and microcirculation disturbance and a preparation method thereof, and the special diet comprises the following components in parts by weight: 2-4 parts of bone collagen peptide, 1-2 parts of taurine, 2-3 parts of hydrolyzed collagen peptide, 1-2 parts of marine fish oligopeptide, 1-2 parts of inulin, 1-2 parts of erythritol, 2-3 parts of acerola cherry fruit powder and 2-3 parts of guarana extract. 1-2 parts of N-acetylneuraminic acid, 1-2 parts of vitamin C, 1-2 parts of vitamin B6, 1-2 parts of vitamin B1 and 1-2 parts of vitamin B2; the traditional Chinese medicine composition can improve cardiovascular functions and microcirculation disturbance, and has remarkable effects in the aspects of inhibiting cardiovascular diseases, promoting microcirculation and enhancing immunity.

The invention discloses a special diet for improving cardiovascular and cerebrovascular diseases and microcirculation disturbance and a preparation method thereof. The health food is prepared from the following raw materials in parts by weight: 30-35 parts of Chinese yam peptide, 30-35 parts of earthworm protein peptide, 20-25 parts of freeze-dried natto powder, 15-20 parts of euphausia superba oil microcapsule powder, 10-15 parts of red yeast rice powder, 5-10 parts of taurine, 5-10 parts of ginseng, 2-5 parts of vitamin C, 2-5 parts of vitamin B1 and 2-5 parts of vitamin B2. The Chinese yam peptide, the earthworm protein peptide, the natto freeze-dried powder, the euphausia superba oil micro-capsule powder, the red yeast rice powder, the taurine, the ginseng, the vitamin C, the vitamin B1 and the vitamin B2 are prepared into the special diet for improving cardiovascular and cerebrovascular diseases and microcirculation disturbance, and various natural plants are matched with active effective components of medicinal and edible foods, so that the special diet has the effects of being medicinal and edible and being free of toxic and side effects. Meanwhile, the nutrition intervention effect is achieved on serious diseases such as cardia-cerebrovascular diseases and the like; the traditional Chinese medicine composition can restore original vitality of heart and cerebral vessels, improve blood and oxygen supply functions of whole body tissues, and reduce blood fat and blood viscosity.

This invention provides an adaptive wearable bio-wave resonance AI Bluetooth smart glasses, belonging to the field of smart glasses technology. It includes: a frame, an adaptive adjustment component, and an intelligent microcirculation control system. The adaptive adjustment component is used to adaptively adjust the microcirculation of the eyes, head, and ears. The Bluetooth intelligent delivery control system is symmetrically mounted on the two temples of the frame and is used to control the adaptive adjustment component. This invention, by combining the adaptive adjustment component and the intelligent microcirculation control system, fundamentally solves the problem of traditional smart Bluetooth glasses only having Bluetooth intelligent delivery functions. It adds a bio-wave resonance chip for synchronous resonance reception and conduction, addressing and improving sub-health issues related to microcirculation disorders in the head, eyes, and ears. The entire adjustment process is automated without manual user intervention. It also features dual-system modes with both passive and active motherboards, and multiple mechanisms such as low-battery safety degradation, combining ease of use, reliability, and security.

The invention relates to an elsholtzia and ginseng composite peptide special diet for improving cardiovascular and cerebrovascular diseases and microcirculation disturbance and a preparation method thereof. The special diet comprises the following components: 5-15% of small molecule peptide; 18-65% of a plant extract; 0.1 to 3 percent of gamma-aminobutyric acid; 0.01 to 1 percent of N-acetylneuraminic acid; 0.005% to 0.1% of thiamine; 0.001 to 0.05 percent of riboflavin; and the balance of auxiliary materials. Wherein the plant extract comprises at least one of elsholtzia, rhizoma zingiberis and ginseng. According to the scheme provided by the invention, the elasticity and permeability of blood capillaries can be improved, microcirculation can be improved, blood fat can be reduced, and cardiovascular and cerebrovascular diseases can be effectively prevented and relieved.

The invention discloses a coronary microcirculation disturbance prediction method, a processing device, a system and a computer readable storage medium, and the method comprises the steps: respectively obtaining motion electrocardio data and resting electrocardio data output through at least one electrocardiogram lead, respectively obtaining first and second high-frequency QRS wave group data according to the motion electrocardio data and the resting electrocardio data, and obtaining first and second lead positive indexes based on the first and second high-frequency QRS wave group data; whether target first high-frequency QRS wave group data exists in the first high-frequency QRS wave group data corresponding to positive indication of the first lead positive index or not is determined, and the target first high-frequency QRS wave group data does not have a first waveform feature indicating coronary artery lesion and a second waveform feature indicating myocardial bridge; and determining the possibility of coronary microcirculation disturbance. According to the scheme, the coronary artery microcirculation disturbance can be noninvasively, rapidly and specifically recognized.

The invention relates to a targeted drug delivery device for improving coronary microcirculation disturbance. The targeted drug delivery device comprises a targeted drug carrying support and an implantation mechanism. One side of the far end of the implantation mechanism is provided with a targeted medicine carrying support installed in a blood vessel; the targeted drug-loading stent comprises a stent body, and micro grooves which are uniformly distributed are formed in the outer surface of the stent body; one side, facing the blood flow of the lumen, of the stent body is coated with a microcirculation improving coating; one side, facing the blood vessel wall, of each micro groove is coated with an anti-proliferation layer; the implantation mechanism comprises a catheter, a guide wire cavity and a drug delivery cavity are formed in the catheter, the guide wire cavity is used for passing of a guide wire, and the drug delivery cavity is used for targeted drug delivery; compared with the prior art, the invention has the following beneficial effects: by physically anchoring a focus through the targeted drug-loaded stent and intelligently responding to a microenvironment through the drug coating, "physical and chemical" dual precise positioning is realized, the local drug concentration is significantly improved, and the untoward effects of the whole body are reduced.

The invention discloses a traditional Chinese medicine composition for preventing and treating sepsis microcirculation and blood coagulation dysfunction. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 20-40 parts of ginseng, 5-15 parts of rheum officinale, 20-40 parts of sargentgloryvine stem, 20-40 parts of dandelion, 20-40 parts of radix aconiti carmichaeli and 2-8 parts of leech. The traditional Chinese medicine composition has the effects of supporting the healthy energy, clearing away heat and toxic materials and promoting blood circulation to remove blood stasis, clinical tests show that the traditional Chinese medicine composition can remarkably improve microcirculation disturbance and blood coagulation dysfunction of a sepsis patient, reduce the 28-day full-cause case fatality rate of the patient, improve multi-organ dysfunction and relieve inflammatory response for the yang-deficiency and toxin-stasis type sepsis patient, and has good safety. In addition, the invention further discloses a preparation method and application of the traditional Chinese medicine composition.

The present disclosure relates to the technical field of medical instruments, in particular to a heart health state evaluation method, processing device, system and computer readable storage medium, by respectively acquiring exercise electrocardiogram data, resting electrocardiogram data and conventional electrocardiogram data output by electrocardiogram leads and analyzing the same to determine the possibility of existence of myocardial ischemia, coronary artery lesion, myocardial bridge and coronary microcirculation disorder, qualitatively evaluating the heart health state according to the determination result, and in the case of determining the possibility of existence of myocardial ischemia and / or coronary artery lesion, quantitatively evaluating the myocardial ischemia and / or coronary artery lesion, and finally evaluating the heart health state according to the qualitative evaluation result and the quantitative evaluation result. The technical scheme provided by the embodiments of the present application can more accurately qualitatively and quantitatively analyze the heart health state by combining exercise electrocardiogram data, resting electrocardiogram data and conventional ECG data.

The present application relates to the technical field of traditional Chinese medicine preparation, in particular to a new application of Xintong preparation in preparing anemic drugs. The present application discloses the clinical application of Xintong preparation composed of 13 kinds of traditional Chinese medicines, such as Huangqi, Dangshen, Maidong, Heshouwu, Yinyanghe, Gegen, Dangui, Danshen, Zaokesheng, Haizao, Kunkunbu, Muli and Zhishi, in treating anemia caused by qi stagnation and blood stasis and phlegm-dampness blockage. Experiments show that the Xintong preparation can significantly improve the hemoglobin level of anemic model rats, and has better effects than the positive control in blood sugar control and kidney tissue repair. The present application expands the clinical application range of Xintong preparation, provides a multi-target treatment scheme for refractory anemia combined with microcirculation disorder and metabolic disorder, and has significant clinical value and innovation.

The application discloses a ginger and jujube group formula, a preparation method thereof and application of the ginger and jujube group formula in prevention and treatment of cold syndrome primary dysmenorrhea products. The ginger and jujube group formula is composed of ginger, jujube, white peony root and fried licorice in a specific ratio, and an extract can be prepared by using a water extraction, alcohol extraction or water extraction and alcohol precipitation process. Experiments prove that the group formula and the extract can improve the cold and blood stasis signs of a cold syndrome primary dysmenorrhea model mouse, reduce writhing responses, reduce uterine and ovarian pathological injuries, down-regulate serum and uterine tissue inflammatory factor levels, and regulate endocrine and microcirculation disorders. The application has the advantages of scientific compatibility, definite curative effect, stable preparation process, high safety, suitability for long-term conditioning and the like, and is used for preventing and treating cold evil invasion and cold and blood stasis type primary dysmenorrhea.

Disclosed are a coronary microcirculation disorder prediction method, a processing device, a system and a computer readable storage medium, the method comprising: acquiring exercise electrocardiogram data and resting electrocardiogram data output by at least one electrocardiogram lead respectively, and obtaining first and second high-frequency QRS complex data respectively based on the exercise electrocardiogram data and the resting electrocardiogram data; obtaining first and second lead positive indicators based on the first and second high-frequency QRS complex data; determining whether target first high-frequency QRS complex data exists in the first high-frequency QRS complex data corresponding to the first lead positive indicator indicating positivity, the target first high-frequency QRS complex data not having a first waveform feature indicating coronary artery disease and a second waveform feature indicating myocardial bridge; and if the target first high-frequency QRS complex data exists, determining that there is a possibility of coronary microcirculation disorder. The present scheme can realize non-invasive, rapid and specific identification of coronary microcirculation disorder.

The application discloses a kind of man-machine adaptability evaluation methods of mattress, it is related to the field of ergonomics health monitoring, including, according to BMI grading standard screening tester and collecting tester's height, weight, gender, age, sleep habit and chronic pain history basic data, obtain the BMI value of tester;Tester BMI value is input into mattress hardness selection model, obtain the test mattress hardness range, in constant temperature and humidity experimental environment, arrange selected hardness bed mattress to be measured, tester is in standard supine position and standard lateral decubitus in turn lie on bed mattress to be measured.The application predicts spine stiffness demand curve in real time through LSTM neural network, realizes millisecond level dynamic support adjustment, response speed is significantly improved compared with traditional method, can prevent spinal compensatory curvature in sleep;Combined with the IRI index calculation of pressure-blood oxygen coupling, accurately warn microcirculation disorder before tissue damage, and solve local ischemia problem through zoning adjustment.

The invention provides a traditional Chinese medicine composition and a traditional Chinese medicine preparation for treating myocardial ischemia-reperfusion injury. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-15 parts of salvia miltiorrhiza, 10-15 parts of radix astragali preparata, 7-11 parts of allium macrostemon, 7-11 parts of cassia twig, 4-8 parts of sandalwood, 4-8 parts of fructus amomi, 7-11 parts of herba epimedii, 10-15 parts of codonopsis pilosula and 3-4 parts of pseudo-ginseng. The traditional Chinese medicine composition follows a method of tonifying qi, warming yang and activating blood, can improve key pathological links such as reperfusion energy metabolism disorder, oxidative stress and inflammatory response, microcirculation disturbance and the like, and is suitable for prevention and treatment of myocardial ischemia reperfusion injury.

The present application relates to a long-changma class derivative and its preparation method and application, belong to long-changma class derivative preparation technical field. The long-changma class derivative disclosed by the present application has the following advantages: (i) the modification of the tail chain increases the fat solubility of the long-changma class compound, and does not affect the brain blood flow regulation of the long-changma class itself, helps to carry the drug to penetrate the blood-brain barrier, and plays a brain protection role, improves the brain microcirculation disorder; (ii) the tertiary amine group in the parent nucleus structure of the long-changma class derivative has the property of ionization under acidic conditions, can achieve efficient carrying and lysosome escape of nucleic acid drugs through charge adsorption, and improve intracellular transport; (iii) the long-changma class derivative inherits the inherent various pharmacological activities of long-changma, and has high safety. Therefore, the long-changma class derivative disclosed by the present application has good application prospect in brain-targeted delivery of drugs for treating brain diseases.

The invention provides a candidate medicine for promoting the embryo implantation efficiency of an endometrial microcirculation disturbance type RIF patient, and belongs to the technical field of embryo implantation. In order to solve the problem of how to find a potential intervention drug aiming at a microcirculation disturbance RIF pathological mechanism, a five-step efficient drug screening strategy based on an in-vitro implantation model of an endometrial microcirculation disturbance type repeated embryo implantation failure is adopted, so that the reliability and functional correlation of a screening result are ensured. The candidate drug screened by adopting a five-step method efficient drug screening strategy comprises any one of the following drugs: phenylbutazone, ferulic acid, L-proline, indinavir, sofalone, trelagliptin and gemcitabine. In the candidate medicines, the phenylbutazone, the ferulic acid and the L-proline are three medicines with the best implantation promoting efficiency for patients with the endometrial microcirculation disturbance type RIF.

The invention is applicable to the technical field of traditional Chinese medicine powder for treating arthralgia and provides traditional Chinese medicine powder for treating arthralgia and a preparation method thereof, and the traditional Chinese medicine powder for treating arthralgia comprises the following substances in parts by mass: 8-12 parts of tripterygium wilfordii, 4-6 parts of ligusticum wallichii, 8-12 parts of salvia miltiorrhiza, 1.6-2.4 parts of mirabilite and 4-6 parts of rheum officinale. According to the traditional Chinese medicine steeping powder for treating arthralgia and the preparation method of the traditional Chinese medicine steeping powder, the traditional Chinese medicine steeping powder takes four mechanisms of immunoregulation, anti-inflammation, blood circulation activation and detumescence as a core, accurate strike on the pathological link of rheumatoid arthritis is formed, triptolide in tripterygium wilfordii can inhibit T cell overactivity and block the start of autoimmune response, and the curative effect is good. Ligustrazine improves joint local microcirculation disturbance by expanding microvessels and inhibiting platelet aggregation, tanshinone has a strong anti-oxidation effect and can remove excessive oxygen free radicals generated in the inflammation process and relieve synovial cell damage, and sodium sulfate in mirabilite can promote absorption of inflammatory exudates in articular cavities and relieve swelling.

The application provides application of a monascus composition in preparation of a medicine for preventing and / or treating coronary microcirculation disorder, wherein the monascus composition comprises one or more of mulberry bark, mulberry branch and mulberry leaf, monascus and pueraria. When the monascus composition is applied in preparation of the medicine for preventing and / or treating coronary microcirculation disorder, the following effects can be achieved: 1) improving microvascular structure abnormality (increasing myocardial microvascular density MVD, reducing perivascular edema of microvessels, improving lumen stenosis phenomenon, and good endothelial cell condition); 2) improving microvascular obstruction (pathological results show that the content of microvessels is reduced); 3) improving abnormal microvascular vasomotor function (increasing NO); 4) improving blood lipid metabolism disorder; and 5) improving heart function (increasing left ventricular ejection fraction LVEF and left ventricular short axis shortening rate LVFS, increasing left ventricular internal pressure maximum rising rate LV+dp / dtmax and left ventricular internal pressure maximum falling rate LV‑dp / dtmax).