51 results about "Microcirculation disorders" patented technology

The invention provides application of a monascus composition in preparation of a medicine for preventing and / or treating coronary microcirculation disturbance. The monascus composition comprises one or more of cortex mori, ramulus mori and folium mori, monascus and radix puerariae. When the composition containing the red yeast rice is applied to preparation of the medicine for preventing and / or controlling coronary microcirculation disturbance, the abnormal microvascular structure can be improved (myocardial microvascular density MVD is increased, edema around microvessels is relieved, the lumen stenosis phenomenon is improved, and the endothelial cell condition is good); 2) microvascular occlusion is improved (pathologic results show that microvascular contents are reduced); (3) the abnormal vasodilatation and contraction function of the microvessels is improved (NO is increased); 4) improving blood lipid metabolism disorder; and (5) the heart function is improved (the left ventricular ejection fraction LVEF and the left ventricular short axis shortening rate LVFS are improved, and the left ventricular pressure maximum rising rate LV + dp / dtmax and the left ventricular pressure maximum falling rate LV-dp / dtmax are increased).

The invention discloses an intelligent analysis and early warning system for potential safety hazards of clinical nursing, and relates to the technical field of intelligent nursing monitoring. Physiological data of a patient is collected in real time and preprocessed, a physiological data set S is constructed and summarized and calculated, characteristic indexes are obtained, and a microcirculation disturbance index Wxh is calculated according to the characteristic indexes; the method comprises the following steps: evaluating the current body state of a patient, constructing a time sequence analysis model, predicting a microcirculation disturbance index Wxh of the patient in a future period of time, evaluating the health state of the patient in the future period of time, carrying out risk early warning, carrying out nursing strategy grading, and carrying out nursing intervention on the patient. The physiological data of the patient in the clinical nursing process are monitored in real time, the clinical nursing effect is optimized, and the nursing efficiency and the nursing safety are improved.

The invention discloses a composition for preventing and treating plateau erythrocythemia and application of the composition, and relates to the technical field of pharmaceutical composition preparation. The composition is prepared from PT2385 and salidroside. The combination of PT2385 and salidroside can effectively inhibit hyperplasia of red blood cells of HAPC rats, reduce hemoglobin and relieve blood flow stasis and microcirculation disturbance of body tissues and organs caused by hypoxia, so that hypoxia phenotypic characteristics of the HAPC rats are improved. In addition, free radicals can be effectively removed, oxidative stress, peroxidation reaction and inflammatory reaction induced by hypoxia are inhibited, the mitochondrial function is protected, and the dysfunction of HAPC rat tissue and organ injury is improved. The problem that in the prior art, an effective medicine for preventing and treating plateau erythrocythemia is lacked is solved.

The invention relates to the technical field of medical instruments, in particular to a heart health state assessment method, a processing device, a system and a computer readable storage medium. Motion electrocardiogram data, resting electrocardiogram data and conventional electrocardiogram data output by electrocardiogram leads are obtained and analyzed to determine the possibility of myocardial ischemia, coronary artery lesion, myocardial bridge and coronary microcirculation disturbance, and the heart health state is qualitatively evaluated according to the determination result. And under the condition that the possibility of myocardial ischemia and / or coronary artery lesion exists is determined, quantitative evaluation is carried out on myocardial ischemia and / or coronary artery lesion, and finally the heart health state is evaluated according to the qualitative evaluation result and the quantitative evaluation result. According to the technical scheme provided by the embodiment of the invention, the heart health state can be more accurately qualitatively and quantitatively analyzed by combining the exercise electrocardio data, the resting electrocardio data and the conventional ECG data.

The invention discloses an experimental material for constructing a cerebral microcirculation disturbance Parkinson's disease animal model and application of the experimental material, and belongs to the technical field of animal model construction. The invention particularly relates to an experimental material for constructing a model, application of the experimental material, a model construction method and application of the model. Research finds that cerebral microcirculation disturbance can cause increase of blood brain barrier permeability, and neuronal damage aggravation caused by penetration of a large amount of inflammatory factors in systemic circulation into the brain; meanwhile, glial cells at the nerve and blood vessel coupling position are activated, tight connection between endothelial cells is damaged, and excessive active oxygen is generated, so that apoptosis of dopaminergic neurons is further aggravated. The research on the Parkinson's disease by adopting the microcirculation disturbance animal model is more in line with the actual pathophysiological environment of the Parkinson's disease patient, and the experimental result has higher reference value.

The invention discloses a construction method of a coronary artery microcirculation disturbance cell model, and belongs to the technical field of biological medicine. According to the method, mouse heart microvascular endothelial cells (MCMEC) are taken as objects, tetrachlorohydroquinone (TCHQ) is used for treating for 6 hours at the concentration of 20-40 [mu] M, and CMD typical characteristics such as apoptosis, increase of reactive oxygen species (ROS), reduction of nitric oxide (NO) and release of inflammatory factors (TNF-alpha and IL-1beta) of the cells are induced. The TCHQ is applied to construction of the CMD model for the first time, and the model is stable, good in repeatability and capable of being used for CMD pathogenesis research and drug screening.

The present application proposes a detection model, construction method and application for coronary microcirculation disorder, and uses the sample entropy, approximate entropy and heterogeneity index of the ECG ST-T segment and the VCG ST-T segment respectively to construct a detection model for coronary microcirculation disorder. The constructed detection model for coronary microcirculation disorder can achieve non-invasive and efficient early screening of coronary microcirculation disorder. The detection model for coronary microcirculation disorder is easy to be loaded on traditional electrocardiogram acquisition devices and has wide clinical application value.

This invention discloses a traditional Chinese medicine composition for improving hypertension, belonging to the field of traditional Chinese medicine compound preparation technology. This invention targets the core pathogenesis of hypertension caused by phlegm-dampness obstruction and peripheral microcirculation disorders, leading to abnormal activation of the hypothalamic-sympathetic-cardiac axis and compensatory cardiac hypertensive. The treatment principle is to resolve phlegm and dampness, and invigorate blood circulation. It is formulated with nutmeg, allium macrostemon, amomum villosum, peach kernel, safflower, platycodon grandiflorus, angelica dahurica, and tangerine peel. This combination can dredge the meridians, improve peripheral blood supply, and alleviate cardiac compensatory pumping, thus addressing hypertension caused by phlegm-dampness obstruction at its root. The formula is scientifically formulated, highly safe, and easy to prepare, making it suitable for long-term treatment and industrial promotion.

The invention belongs to the technical field of burn wound analysis. According to the skin burn analysis method and system based on contrast agent blood perfusion, firstly, a fluorescence sequence after a contrast agent is injected is obtained, and a preprocessing sequence is generated through area cutting and down-sampling; a fluorescence intensity time curve of each pixel point is extracted, peak time is determined, and statistics is carried out to construct a peak time histogram; performing smooth denoising, extreme value detection and weak peak removal on the histogram, and adaptively selecting a threshold value for distinguishing normal and burnt tissues; generating an initial mask by using the threshold value, and performing connected domain analysis and morphological post-processing to obtain a target burn area mask; and finally, generating a pseudo-color image in combination with peak time. According to the method, the time dynamic characteristic of blood perfusion is fully utilized, the burn area can be accurately segmented and the microcirculation disturbance degree can be visually presented without depending on skin textures or a large amount of training data, and the objectivity and accuracy of burn depth evaluation are remarkably improved.

The invention provides a method for inhibiting the progress of diabetic retinopathy, and the method specifically comprises the following steps: S1, inhibiting the formation of new vessels: reducing the formation of new vessels through tissue hypoxia caused by an inhibitor; s2, inhibiting the expression of TNF-a by using a high-dose anti-inflammatory drug: reducing the adhesion of retinal leukocytes; s3, improving microcirculation and reducing blood high viscosity, namely enhancing the flexibility of red blood cells through a medicine, reducing the high cohesiveness of the red blood cells, and inhibiting the synthesis and release of platelet aggregation factors; s4, delaying retinopathy by the calcium ion antagonist: inhibiting and removing oxygen free radicals, improving blood rheology and inhibiting platelet aggregation; and S5, improving microcirculation disturbance and retinopathy by using isoflavone substances: inhibiting the occurrence speed of the lesion and relieving symptoms. According to the method for inhibiting the progress of the diabetic retinopathy, the progress of the diabetic retinopathy can be inhibited through reasonable medicine intervention, so that the development of a therapeutic scheme of the diabetic retinopathy is promoted.

The invention discloses a preparation method of a coronary artery microcirculation disturbance animal model, and belongs to the technical field of biological medicine. According to the method, the stable mouse CMD model can be established by injecting 20-40 [mu] g / mL Calcimycin into the cardiac apex for the first time. Calcimycin is a calcium ion (Ca < 2 + >) carrier commonly used in a laboratory and can transport calcium ions outside cells into the cells, so that the concentration of the calcium ions in the cells is increased. Particularly, when 40 [mu] g / mL of Calcimycin is injected, the pathological severity of the Calcimycin is further aggravated, myocardial fiber arrangement is disordered, boundary is unclear, a large number of myocardial cells are necrotic and dissolved, cavitation is formed, vascular wall degeneration swelling is caused, inflammatory cell infiltration is caused, and thrombus is formed in microvessels.

The application provides a candidate drug for promoting embryo implantation efficiency of a patient with endometrial microcirculation disorder type RIF, and belongs to the technical field of embryo implantation. In order to solve the problem of how to find a potential intervention drug for the pathological mechanism of microcirculation disorder type RIF, a five-step high-efficiency drug screening strategy based on an in-vitro implantation model of endometrial microcirculation disorder type repeated embryo implantation failure is adopted to ensure the reliability and functional correlation of the screening result. The candidate drug screened by the five-step high-efficiency drug screening strategy includes any one of the following drugs: phenylbutazone, ferulic acid, L-proline, indinavir, solfazone, teneligliptin and gemcitabine. Among the candidate drugs, phenylbutazone, ferulic acid and L-proline are the best three drugs for promoting the implantation efficiency of the patient with endometrial microcirculation disorder type RIF.

The invention discloses a method for establishing a rat bionic model for sudden deafness caused by inner ear microcirculation disturbance, and relates to the technical field of animal model construction.The method comprises the steps that exosome extraction and purification are conducted, specifically, healthy rat bone marrow is obtained, mesenchymal stem cells are extracted and placed in a culture bottle to be cultured, cell culture supernate is collected, and the exosome is obtained; extracting exosomes by adopting an ultracentrifugation method; loading of the procoagulant factor and the exosome: selecting a prothrombin fragment as the procoagulant factor, treating the prothrombin fragment, and mixing the obtained exosome resuspension and the prothrombin fragment solution according to the volume ratio of 1: 1. The exosome derived from the mesenchymal stem cells is adopted as a procoagulant factor carrier, the source is wide, and the exosome is easy to obtain; the exosome is stable in yield and good in biocompatibility, damage to inner ear tissues of rats can be reduced, and the exosome has natural targeting transportation capacity and can be specifically combined with inner ear vascular endothelial cells, so that the concentration of a procoagulant factor at a target site is increased, and the accuracy of model establishment is enhanced.

The present application belongs to the technical field of sports rehabilitation, and aims at the technical problem that the current expert consensus is mainly to guide the patients after interventional therapy to carry out cardiac rehabilitation, and the population is not defined on the patients with angina after PCI, so the guidance of sports rehabilitation treatment is not accurate, and there is currently a lack of cardiac rehabilitation guidance technology for such patients. The present application adopts one-stop load myocardial perfusion technology, and combines cardiopulmonary exercise test to evaluate the cardiopulmonary function of the patient and formulate the exercise intensity. On the basis of the cardiopulmonary exercise test data and the clinical data of the patient, the transmural index of myocardial perfusion, a semi-quantitative index, is used to grade the microcirculation disorder, and the exercise intensity scheme of the patient is adjusted on this basis. After the evaluation of the present application by myocardial perfusion, the patient is given higher intensity training, and the degree of increase of VO2 is significantly improved compared with the traditional rehabilitation scheme.

The present invention discloses a method for assessing myocardial ischemia, comprising: acquiring a first image (CCTA) and a second image (CTP); obtaining a mapping image based on the first image and the second image; calibrating a target vascular perfusion area in the mapping image; and obtaining myocardial blood flow (MBF) in the target vascular perfusion area under stenosis conditions based on the second image and the target vascular perfusion area. hyper‑stenosis ; Obtain myocardial blood flow MBF under simulated normal conditions hyper‑normal MBF is the myocardial blood flow in the target vascular perfusion area under stenosis conditions. hyper‑stenosis and myocardial blood flow (MBF) under simulated normal conditions hyper‑normal , assessing the proportion of myocardial ischemia caused by coronary artery stenosis using CTP-FFR. The present invention, through the aforementioned method, enables rapid and accurate quantitative assessment of overall myocardial ischemia. The present invention also discloses a myocardial ischemia assessment system, a microcirculatory disorder assessment method and system, a microcirculatory disorder resistance calculation method and system, an electronic device, and a computer-readable storage medium.

This invention discloses a traditional Chinese medicine composition and its application for clearing blood vessels, dissolving blood spots, regulating the five internal organs, and preventing and treating arteriosclerosis and its associated coronary heart disease, hypertension, hyperlipidemia, hyperglycemia, hyperuricemia, and diabetic gangrene. It belongs to the field of traditional Chinese medicine composition technology. The preparation method of the traditional Chinese medicine composition is as follows: (1) treating *Salvia miltiorrhiza*, *Polygonatum sibiricum*, and *Polygonum multiflorum* with alcohol using ultrasound to obtain an alcohol extract and residue; (2) extracting *Lycium barbarum*, *Epimedium brevicornu*, *Ligustrum lucidum*, *Angelica sinensis*, *Cuscuta chinensis*, *Astragalus membranaceus*, *Crataegus pinnatifida*, *Ziziphus jujuba*, *Chrysanthemum morifolium*, and *Lycium chinense* with water to obtain an aqueous extract; (3) mixing the residue and aqueous extract and enzymatically hydrolyzing to obtain an enzymatic hydrolysate; (4) mixing the alcohol extract and enzymatic hydrolysate and drying. The enzymes are yeast extractase, cellulase, and bromelain in a mass ratio of 0.5-1:1:0.1-0.3. Compared with existing technologies, this invention can improve microcirculation disorders and can be used to prevent and treat various diseases caused by microvascular circulation disorders.

The invention discloses a yang-warming and cold-dispelling health-care liquid and a preparation method thereof. The aconitine content is less than or equal to 0.015 mg / mL and the heat effect lasting time is more than or equal to 8 hours by combining the radix aconiti carmichaeli-rhizoma zingiberis toxicity attenuation synergistic compatibility with the phase change temperature control technology. The transdermal rate of the masticinic acid is increased by 3.5 times by innovatively adopting a micro-jet nanocrystallization process, and the production safety is ensured by matching with near-infrared online monitoring. Animal experiments prove that microcirculation disturbance can be remarkably improved (the blood flow speed is increased by 178%), and the traditional Chinese medicine composition is suitable for local warming and dredging conditioning of people with yang-deficiency constitution.

The invention discloses a single-stage negative oxygen ion flow device for purifying blood cells, which belongs to the technical field of electrotherapy, negative ion therapy and blood purification, and comprises a single-stage negative oxygen ion generation and targeted guide and grounding loop. According to the device, a high-purity negative oxygen ion flow with the particle size smaller than 0.01 mu m is generated through a single-stage negative high voltage and double shielding technology and enters a human body through skin / respiratory tract double paths, a device-human body-ground closed charge circulation loop is constructed, deep purification of blood cells is achieved through quadruple mechanisms such as cell membrane potential repair, and the purpose of purifying the blood cells is achieved. The device is suitable for household blood health care and auxiliary treatment of hyperviscosity and microcirculation disturbance of medical institutions, solves the problems of low ion purity, poor penetrability, target deficiency and the like of traditional equipment, and is high in safety and remarkable in purification effect.

The invention discloses a special diet for improving cardiovascular and cerebrovascular diseases and microcirculation disturbance and a preparation method thereof, and the special diet comprises the following components in parts by weight: 2-4 parts of bone collagen peptide, 1-2 parts of taurine, 2-3 parts of hydrolyzed collagen peptide, 1-2 parts of marine fish oligopeptide, 1-2 parts of inulin, 1-2 parts of erythritol, 2-3 parts of acerola cherry fruit powder and 2-3 parts of guarana extract. 1-2 parts of N-acetylneuraminic acid, 1-2 parts of vitamin C, 1-2 parts of vitamin B6, 1-2 parts of vitamin B1 and 1-2 parts of vitamin B2; the traditional Chinese medicine composition can improve cardiovascular functions and microcirculation disturbance, and has remarkable effects in the aspects of inhibiting cardiovascular diseases, promoting microcirculation and enhancing immunity.

The invention discloses a special diet for improving cardiovascular and cerebrovascular diseases and microcirculation disturbance and a preparation method thereof. The health food is prepared from the following raw materials in parts by weight: 30-35 parts of Chinese yam peptide, 30-35 parts of earthworm protein peptide, 20-25 parts of freeze-dried natto powder, 15-20 parts of euphausia superba oil microcapsule powder, 10-15 parts of red yeast rice powder, 5-10 parts of taurine, 5-10 parts of ginseng, 2-5 parts of vitamin C, 2-5 parts of vitamin B1 and 2-5 parts of vitamin B2. The Chinese yam peptide, the earthworm protein peptide, the natto freeze-dried powder, the euphausia superba oil micro-capsule powder, the red yeast rice powder, the taurine, the ginseng, the vitamin C, the vitamin B1 and the vitamin B2 are prepared into the special diet for improving cardiovascular and cerebrovascular diseases and microcirculation disturbance, and various natural plants are matched with active effective components of medicinal and edible foods, so that the special diet has the effects of being medicinal and edible and being free of toxic and side effects. Meanwhile, the nutrition intervention effect is achieved on serious diseases such as cardia-cerebrovascular diseases and the like; the traditional Chinese medicine composition can restore original vitality of heart and cerebral vessels, improve blood and oxygen supply functions of whole body tissues, and reduce blood fat and blood viscosity.

The invention belongs to the technical field of exercise rehabilitation, and aims to solve the problems that at present, expert consensus is mainly used for guiding patients after interventional therapy to perform heart rehabilitation, people are not defined on patients suffering from angina pectoris after PCI (Peripheral Component Interconnect), so that the guidance of the patients on exercise rehabilitation is inaccurate, and the rehabilitation effect is poor. In order to solve the technical problems in the prior art that heart rehabilitation guidance for the patients is lacked at present, a one-stop load myocardial perfusion technology is adopted, cardiopulmonary function evaluation is performed on the patients and exercise intensity is formulated in combination with cardiopulmonary exercise tests, and on the basis of cardiopulmonary exercise test data and clinical data of the patients, the cardiopulmonary exercise intensity is formulated. The microcirculation disturbance is graded by adopting a semi-quantitative index, namely a myocardial perfusion transmural index, and the exercise intensity scheme of a patient is adjusted on this basis. After myocardial perfusion is adopted for evaluation, higher-intensity training is provided for a patient, and the VO2 rising degree is remarkably improved compared with a traditional rehabilitation scheme.

This invention provides an adaptive wearable bio-wave resonance AI Bluetooth smart glasses, belonging to the field of smart glasses technology. It includes: a frame, an adaptive adjustment component, and an intelligent microcirculation control system. The adaptive adjustment component is used to adaptively adjust the microcirculation of the eyes, head, and ears. The Bluetooth intelligent delivery control system is symmetrically mounted on the two temples of the frame and is used to control the adaptive adjustment component. This invention, by combining the adaptive adjustment component and the intelligent microcirculation control system, fundamentally solves the problem of traditional smart Bluetooth glasses only having Bluetooth intelligent delivery functions. It adds a bio-wave resonance chip for synchronous resonance reception and conduction, addressing and improving sub-health issues related to microcirculation disorders in the head, eyes, and ears. The entire adjustment process is automated without manual user intervention. It also features dual-system modes with both passive and active motherboards, and multiple mechanisms such as low-battery safety degradation, combining ease of use, reliability, and security.

The invention relates to an elsholtzia and ginseng composite peptide special diet for improving cardiovascular and cerebrovascular diseases and microcirculation disturbance and a preparation method thereof. The special diet comprises the following components: 5-15% of small molecule peptide; 18-65% of a plant extract; 0.1 to 3 percent of gamma-aminobutyric acid; 0.01 to 1 percent of N-acetylneuraminic acid; 0.005% to 0.1% of thiamine; 0.001 to 0.05 percent of riboflavin; and the balance of auxiliary materials. Wherein the plant extract comprises at least one of elsholtzia, rhizoma zingiberis and ginseng. According to the scheme provided by the invention, the elasticity and permeability of blood capillaries can be improved, microcirculation can be improved, blood fat can be reduced, and cardiovascular and cerebrovascular diseases can be effectively prevented and relieved.

The present invention relates to recombinant batroxobin and a method for its preparation on an industrial scale with high expression level. Specifically, the method for preparing recombinant batroxobin according to the present invention is to artificially synthesize the structural gene sequence of batroxobin, then use Pichia pastoris to clone and express to screen and obtain the seed liquid of a high-expression engineering strain, and then ferment and culture to prepare recombinant batroxobin according to the following operations: preparation of primary seed liquid, preparation of secondary seed liquid, inoculation and pre-culture in a fermenter, glycerol fed-batch culture, methanol fed-batch induction culture, concentration to obtain a fermentation concentrate containing recombinant batroxobin and optionally purifying it. This recombinant batroxobin can be clinically used for acute cerebral infarction, for improving ischemic symptoms caused by various occlusive vascular diseases (such as thromboangiitis obliterans, deep phlebitis, pulmonary embolism, etc.), and for improving peripheral and microcirculation disorders (such as sudden deafness, motion sickness). The expression level of batroxobin by the method of the present invention is high, and industrial-scale production can be easily achieved.

The application discloses a traditional Chinese medicine composition for treating sepsis gastrointestinal dysfunction and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises A medicinal liquid, and the A medicinal liquid is prepared from the following components in parts by weight: 15 parts by weight of ginseng, 9 parts by weight of rhubarb, 15 parts by weight of angelica, 30 parts by weight of alisma, 6 parts by weight of fried licorice, 15 parts by weight of bitter orange fruit, 15 parts by weight of magnolia, 6 parts by weight of platycodon, 15 parts by weight of snake gourd, 30 parts by weight of atractylodes and 780 parts by weight of water. The traditional Chinese medicine composition can effectively relieve gastrointestinal symptoms of constipation and abdominal distension type sepsis gastrointestinal dysfunction, reduce intra-abdominal pressure, improve blood supply of intra-abdominal organs, improve lung compliance and cardiac return blood volume, reduce systemic inflammatory response, protect intestinal mucosal barrier function and improve microcirculation disorder.

The invention discloses a coronary microcirculation disturbance prediction method, a processing device, a system and a computer readable storage medium, and the method comprises the steps: respectively obtaining motion electrocardio data and resting electrocardio data output through at least one electrocardiogram lead, respectively obtaining first and second high-frequency QRS wave group data according to the motion electrocardio data and the resting electrocardio data, and obtaining first and second lead positive indexes based on the first and second high-frequency QRS wave group data; whether target first high-frequency QRS wave group data exists in the first high-frequency QRS wave group data corresponding to positive indication of the first lead positive index or not is determined, and the target first high-frequency QRS wave group data does not have a first waveform feature indicating coronary artery lesion and a second waveform feature indicating myocardial bridge; and determining the possibility of coronary microcirculation disturbance. According to the scheme, the coronary artery microcirculation disturbance can be noninvasively, rapidly and specifically recognized.

The invention relates to a targeted drug delivery device for improving coronary microcirculation disturbance. The targeted drug delivery device comprises a targeted drug carrying support and an implantation mechanism. One side of the far end of the implantation mechanism is provided with a targeted medicine carrying support installed in a blood vessel; the targeted drug-loading stent comprises a stent body, and micro grooves which are uniformly distributed are formed in the outer surface of the stent body; one side, facing the blood flow of the lumen, of the stent body is coated with a microcirculation improving coating; one side, facing the blood vessel wall, of each micro groove is coated with an anti-proliferation layer; the implantation mechanism comprises a catheter, a guide wire cavity and a drug delivery cavity are formed in the catheter, the guide wire cavity is used for passing of a guide wire, and the drug delivery cavity is used for targeted drug delivery; compared with the prior art, the invention has the following beneficial effects: by physically anchoring a focus through the targeted drug-loaded stent and intelligently responding to a microenvironment through the drug coating, "physical and chemical" dual precise positioning is realized, the local drug concentration is significantly improved, and the untoward effects of the whole body are reduced.

The invention discloses a traditional Chinese medicine composition for treating sepsis gastrointestinal dysfunction and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises a liquid medicine A, wherein the liquid medicine A is prepared from the following components in parts by weight: 15 parts of ginseng, 9 parts of rheum officinale, 15 parts of angelica sinensis, 30 parts of rhizoma alismatis, 6 parts of honey-fried licorice root, 15 parts of immature bitter orange, 15 parts of mangnolia officinalis, 6 parts of platycodon grandiflorum, 15 parts of trichosanthes kirilowii maxim, 30 parts of bighead atractylodes rhizome and 780 parts of water. The traditional Chinese medicine composition can effectively relieve gastrointestinal symptoms of constipation and abdominal distension type sepsis gastrointestinal dysfunction, relieve pressure in the abdominal cavity, improve blood supply of visceral organs in the abdominal cavity, improve lung compliance and return blood volume, relieve inflammatory response of the whole body, protect the intestinal mucosa barrier function and improve microcirculation disturbance.

The invention discloses a traditional Chinese medicine composition for preventing and treating sepsis microcirculation and blood coagulation dysfunction. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 20-40 parts of ginseng, 5-15 parts of rheum officinale, 20-40 parts of sargentgloryvine stem, 20-40 parts of dandelion, 20-40 parts of radix aconiti carmichaeli and 2-8 parts of leech. The traditional Chinese medicine composition has the effects of supporting the healthy energy, clearing away heat and toxic materials and promoting blood circulation to remove blood stasis, clinical tests show that the traditional Chinese medicine composition can remarkably improve microcirculation disturbance and blood coagulation dysfunction of a sepsis patient, reduce the 28-day full-cause case fatality rate of the patient, improve multi-organ dysfunction and relieve inflammatory response for the yang-deficiency and toxin-stasis type sepsis patient, and has good safety. In addition, the invention further discloses a preparation method and application of the traditional Chinese medicine composition.