The invention relates to a [<18>F]-fluoromethyl
triphenylphosphine salt, a preparation method and application thereof, and effectively solves the problem of low ratio of myocardial uptake and non-target organs in existing
myocardial perfusion imaging agents. The method includes: dissolving silver p-toluenesulfonate in
acetonitrile, adding
diiodomethane under stirring, conducting heating
reflux, performing cooling to
room temperature, filtering out light yellow solids, removing the
solvent by
spinning, and eluting and purifying the residue to obtain bis(p-toluenesulfonyl)-
methane; under
nitrogen protection, adding a [<18>F]
fluoride solution into a K2.2.2 solution and a K2CO3 solution, performing
drying, adding
acetonitrile, conducting
drying again, adding bis(p-toluenesulfonyl)
methane and
anhydrous acetonitrile into the dried substance, carrying out reaction, and performing cooling to
room temperature, conducting
column chromatography, adding an acetonitrile solution containing triphenyl
phosphine to carry out reaction, and then performing cooling, filtering, column purification,
solvent removal, normal
saline dissolution and filtering, thus obtaining the [<18>F]-fluoromethyl
triphenylphosphine salt. The [<18>F]-fluoromethyl
triphenylphosphine salt provided by the invention has the characteristics of high cardiac and myocardial uptake, fast
clearance rate in main organs, and high heart blood ratio, heart-
lung ratio and heart-liver ratio, low cost, and can acquire clear heart Micro-PET images.