Exemplary
artificial intelligence (AI) systems, methods and computer-accessible medium can be provided for detecting a
breast cancer using
mammography. For example, using at least one computer processor, it is possible to receive a
mammography image, apply a neural network employing, e.g., a You Only Look Once X (YOLOX) architecture to predict one or more locations and probabilities of lesions. Further, with such exemplary systems, methods and computer-accessible medium, it is possible to make an overall image-level prediction for the received
mammography image so as to provide a particular
breast cancer prediction. It is also possible to generate breast-level predictions by averaging all predictions from FFDM, C-View, DBT modalities for each breast. For example, when used in
clinical decision support, the exemplary model can reduce radiologist
workload by, e.g., about 45% and unnecessary recalls by, e.g., about 32.4%, without missing malignancies.