8 results about "Calcification" patented technology

The application discloses a method for synergistically inducing calcium carbonate deposition and solidification by bacillus subtilis and sphaerotilus paratus. The method comprises the following steps: 1) adding a composite bacterial solution containing bacillus subtilis and sphaerotilus paratus to treat loose particles; and 2) adding a calcification solution to post-treat the treated loose particles. The application also provides bacillus subtilis with a preservation number of CCTCC NO: M 20231896. The composite bacterial solution containing bacillus subtilis and sphaerotilus paratus synergistically promotes the induced calcification efficiency of microorganisms, and improves the cementation performance, toughness and hardness of the calcification material.

The application relates to the technical field of natural high-molecular compound processing and medical materials, and discloses a method for preparing mineralized collagen based on a synchronous biomimetic calcification and siliconization strategy. The preparation method comprises the following steps: dissolving collagen in a buffer solution, adding a soluble calcium ion solution, adjusting the pH value to 8-10 under the condition of an ice water bath, then culturing under stirring and constant temperature conditions for 15-30 min; then adding a silicate and phosphate mixed solution dropwise under stirring, adjusting the pH value to 8-10, and then constant temperature culture for 12-24 h; and the mineralized collagen material prepared by separating the precipitate, washing with water and freeze-drying has synchronous biomimetic calcification and siliconization. The composite material constructed by the application has a high mineralization degree close to that of natural bone, exhibits good biocompatibility, can effectively promote the proliferation and differentiation of osteoblasts, and has a good application prospect in the field of bone repair and the like.

The invention relates to the technical field of calcification accumulation, and particularly discloses a device for intercepting accumulation of calcification in a drainage ditch, comprising a drainage ditch body; the supporting element is used for providing supporting and positioning for the whole device and is located in the drainage ditch body; the impurity containing element is arranged on the supporting element and used for bearing and storing impurities carried by water flow in the drainage ditch; the adsorption element is arranged at the water flow inlet and outlet end of the impurity containing element and used for adsorbing and intercepting impurities in water flow, through cooperation of all elements in the adsorption element, the impurities carried by the water flow can be automatically adsorbed, intercepted, filtered and stored in the daily drainage process, the source of formation of calcification is reduced, and the drainage efficiency is improved. And compared with a traditional regular comprehensive cleaning mode, a large amount of manpower does not need to be frequently used for comprehensive cleaning, and the labor cost input is greatly reduced.

The present application discloses a mineralization material for treating dentin hypersensitivity and promoting epitaxial growth of enamel, and its use, which comprises, by weight, 5-72 parts of a membrane-forming protein or PEGylated membrane-forming protein, 4-67 parts of a water-soluble disulfide exchanger, and 1-21 parts of a pH adjuster. The present application first proposes using a non-toxic disulfide exchanger (e.g., cysteine ​​(Cys)) to react with a membrane-forming protein or PEGylated membrane-forming protein, so that when a protein nano-coating layer with a mineralization-regulating function is formed, a large amount of high molecular weight protein aggregates that block dentin pores are not generated, the permeability is better, and the protein nano-coating layer can penetrate deeper into the already exposed dentin pores, reaching a depth of 200-500 μm (the blocking depth of the protein coating layer reacting with TCEP is only about 40 μm), and can reach the recesses of pits and fissures.

The present invention provides a nanostructure of a laser surface-treated bone material. [Solution] The surface of the bone material is titanium metal 3, and molten titanium metal is formed by laser sputtering. After cooling, it has at least one microchannel 10 made of titanium dioxide (TiO2). The nanostructure of the bone material includes at least one micropore 12, at least one guide channel 16, at least one nanoprotrusion particle layer 111 formed by at least one nanowall 11, and at least one nanowall. The effects and purposes of improving bone healing and antibacterial indicators are achieved: A. accelerating the deposition of bone healing-related proteins; B. accelerating the attachment of bone cells; C. inducing neovascularization; D. accelerating early calcification and bone mineralization; E. improving the exchange of nutrients; F. stabilizing the surface bone structure; and G. inhibiting plaque formation.

To provide methods for treating disease and disorders associated with pathological calcification or pathological ossification.SOLUTION: The method comprises administering a composition comprising at least one agent selected from the group consisting of Ecto-Nucleotide pyrophosphate / Phosphodiesterase-1 (NPP1) polypeptide and a fragment, derivative, mutant or mutant fragment thereof, and an activator of NPP1 polypeptide and a fragment, mutant or mutant fragment thereof. Preferably, the NPP1 polypeptide or a fragment, mutant or mutant fragment thereof is a soluble recombinant NPP1 polypeptide or a fragment, mutant or mutant fragment thereof.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of marine ecological protection and aquaculture, and discloses an intervention method for relieving acid etching damage of shellfish larvae, according to the method, by adding strontium ions (Sr) with different concentrations into seawater, the malformation rate of the shellfish larvae under the acidification condition can be effectively reduced, the shell length, the mechanical property and the calcified gene expression level can be improved, and the acid etching damage of the shellfish larvae can be relieved. Therefore, the embryo shell forming ability and the acid corrosion resistance are enhanced; according to the invention, Ruditapes philippinarum, Crassostrea sikamea and Pinctada martensii are used as representatives, strontium intervention experiments are respectively carried out in seawater with pH values of 8.1, 7.7 and 7.4, and results show that a proper amount of strontium can significantly enhance the hardness and toughness of shells, and a more stable Sr-Ca eutectic structure is formed by partially replacing Ca in the shells, so that the stress resistance of larvae is improved. The method is quick in effect, wide in application range and suitable for embryo shell protection and cultivation stress resistance enhancement in the cultivation process of various shellfish seedlings.