634 results about "Dialysis" patented technology

The invention discloses a medicine dialysis dry powder production whole process intelligent supervision method, and belongs to the technical field of medicine production intelligent monitoring. The method comprises the following steps: collecting a raw material purity parameter, a mixing process microscopic parameter and a finished product performance index parameter in real time through a sensor array module; the data processing module performs preprocessing and feature extraction on the collected parameters; the deep learning model module carries out training based on the preprocessed parameters to generate a dynamic ratio adjustment scheme; the control module controls the raw material conveying amount of the production equipment according to the adjustment scheme; and the closed loop feedback module feeds back the adjusted finished product performance index parameters to the deep learning model module to form a dynamic optimization closed loop. The method further comprises an abnormity early warning step and a model iteration step, the whole-process intelligent supervision of the medicine dialysis dry powder production process is realized, the proportion can be automatically adjusted according to the purity fluctuation of the raw materials, the stable product quality is ensured, the production efficiency is improved, and the manual intervention requirement is reduced.

The invention discloses a corn peptide for dispelling effects of alcohol and protecting liver as well as a preparation method and application thereof, and belongs to the technical field of biological peptide extraction. The preparation method comprises the following steps: crushing and sieving corn, dissolving the corn in deionized water, adjusting the pH value to be alkaline, and performing ultrasonic-assisted extraction to obtain corn homogenate; centrifuging, taking supernate, adjusting the pH to be neutral, centrifuging, adding an ethanol solution with the mass fraction of 10%, standing, carrying out continuous flow centrifugation, suspending precipitates in distilled water, dialyzing in a dialysis bag, and freeze-drying to obtain crude corn protein; the preparation method comprises the following steps: preparing an aqueous solution, carrying out variable-temperature treatment, adjusting the pH value to be alkaline, adding trypsin and alkaline protease, carrying out enzymolysis, repeating the enzymolysis twice, and after the enzymolysis is finished, carrying out heating enzyme deactivation, centrifugation, sediment discarding, ultrafiltration, centrifugation, supernatant taking and spray drying to obtain the corn peptide. The corn peptide can remarkably shorten the drunkenness time and sobering time of mice and reduce the drunkenness duration, and has good effects of dispelling the effects of alcohol and protecting the liver.

The invention relates to a preparation method of a microwave-assisted synthesized near-infrared electrochemical luminescence gold nanocluster and application of the gold nanocluster in miRNA (micro Ribonucleic Acid) detection. The preparation method comprises the following steps: under a stirring condition, adding a gold source and alkali into a Met solution to obtain a mixed solution, carrying out microwave irradiation reaction, and carrying out solid-liquid separation to obtain a Met-Au NCs solution; the preparation method comprises the following steps: activating a Met-Au NCs solution by using EDC and NHS, adding a DNA solution, mixing, and dialyzing to obtain a Met-Au NCs-DNA compound, namely the near-infrared electrochemical luminescence gold nanocluster. Compared with Au NCs prepared by a common mild method, the Met-stable Au NCs prepared by a microwave-assisted method has the advantage that the fluorescence and electrochemical luminescence efficiency at 835 nm is improved. The invention also provides a'signal closing 'ECL (electron cyclotron ligand) biosensor for high-sensitivity detection of the miRNA-107 (MicroRNA-107), and a method for detecting the miRNA-107 (MicroRNA-107). The sensor is simple to operate and good in repeatability, and has important scientific significance and application value for clinical early diagnosis of cancers.

The invention discloses chiral ionizable lipid nanoparticles and a preparation method thereof, and belongs to the technical field of biomedical materials. The chiral ionizable lipid nanoparticle comprises chiral amino acid derived lipid, ionizable lipid, auxiliary lipid, cholesterol, a phospholipid polyethylene glycol derivative and an RNA (Ribonucleic Acid) drug, the preparation method comprises the following steps: dissolving chiral amino acid derived lipid in methanol, respectively dissolving ionizable lipid, auxiliary lipid, cholesterol and phospholipid polyethylene glycol derivative in ethanol, and mixing to obtain a total lipid organic phase; dissolving an RNA drug in DEPC water to obtain an RNA aqueous solution, and mixing the RNA aqueous solution with an acidic buffer solution to obtain an RNA aqueous phase; quickly mixing the total lipid organic phase and the RNA water phase, and standing and incubating; adding the mixed solution into a 3500 Da dialysis bag, taking 1 * phosphate buffer solution (PBS, pH = 7.4) as an external water phase, and dialyzing to obtain the chiral ionizable lipid nanoparticles. The lipid nanoparticles provided by the invention can enhance the RNA uptake efficiency, and have good application prospects in the treatment of systemic inflammation and other diseases.

The invention discloses a self-adaptive hydrogel coupling agent as well as a preparation method and application thereof, belongs to the field of medical instruments, and particularly relates to a preparation method of the self-adaptive hydrogel coupling agent. The preparation method comprises the following steps: dissolving a main monomer, a functional monomer, a molecular weight regulator and a reinforcing filler in sterilized deionized water under dark and sterile conditions, carrying out a free radical polymerization reaction under the action of a persulfate solution and tetramethylethylenediamine, and carrying out dialysis and sterilization treatment to obtain the self-adaptive hydrogel coupling agent. The self-adaptive hydrogel coupling agent prepared by the invention eliminates tissue deformation caused by probe pressurization, significantly improves the accuracy of measurement of the actual distance of a target by ultrasound in an operation, and meanwhile, the self-adaptive hydrogel coupling agent is good in biocompatibility, can be sterile, is convenient to operate, and is suitable for open or endoscopic surgical wounds.

The invention relates to the field of medical informatics, and provides a hemodialysis multi-mode risk closed-loop control system. Comprising a multi-source data acquisition module used for acquiring heterogeneous data in a dialysis process in real time; the space-time fusion engine module is used for carrying out space-time alignment and feature extraction of cross-modal data on the heterogeneous data by adopting a graph neural network architecture to generate a fusion feature vector; the dynamic risk prediction module is used for constructing a multi-dimensional risk assessment system based on the fusion feature vector, carrying out probability prediction on multiple risk types and outputting a prediction result; and the intelligent intervention control module evaluates the risk level according to the prediction result output by the dynamic risk prediction module, and generates an intervention strategy through a reinforcement learning algorithm. According to the invention, the timeliness and accuracy of intervention response are improved, and the incidence rate of dialysis complications is reduced.

Provided herein is a method of using digital twins for medical diagnosis, prediction, and / or prognosis of a disease or condition, such as diagnosis, prediction, and / or prognosis of one or more cancers, organ-specific age prediction, predicting of female aging, predicting hospital-acquired infection, predicting dialysis time series, predicting diabetes and complications, predicting pregnancy and child outcome, predicting heart failure, predicting myopia, predicting vision in anti-VEGF treatment, or any combination thereof. A system and non-transitory computer-readable storage medium configured for performing the method is also disclosed.

The invention relates to the crossing field of computer technology and edge calculation, and discloses a blood purification equipment real-time control method based on edge calculation. According to the method, multi-modal real-time physiological parameters, historical dialysis data and a current treatment target are fused through a local edge calculation unit, an individualized body fluid dynamic response prediction model is constructed, and an ultrafiltration rate instruction is optimized and generated within a millisecond level; the system comprises a multi-mode sensor array, a historical data storage module, a task planning interface, an edge computing unit and an ultrafiltration pump controller. According to the application, the hemodynamic state is accurately maintained, the risk of hypotension is remarkably reduced, and the treatment safety and individualization level are improved.

The invention relates to the technical field of intelligent monitoring, and particularly discloses an intelligent monitoring method and system for hemodialysis patient complications, and the method comprises the following steps: S1, carrying out the fusion to form a multi-modal feature set, S2, constructing an individualized risk feature map, S3, generating complication risk probability distribution, S4, calculating an individualized risk threshold value, and S5, generating an intervention suggestion sequence. The method comprises the following steps: acquiring physiological parameters of a hemodialysis patient and operation parameters of dialysis equipment, identifying a coupling relationship between the parameters, constructing an individualized risk characteristic spectrum, predicting a characteristic change trend, matching the characteristic change trend with a historical complication mode, calculating an individualized risk threshold to trigger early warning, generating targeted intervention suggestions, and monitoring an effect. According to the system, the accuracy and timeliness of hemodialysis complication monitoring are effectively improved, the complication occurrence rate is reduced, the workload of medical staff is relieved, and the safety and effectiveness of hemodialysis treatment are improved.

The utility model relates to the technical field of water pollution treatment, in particular to a landscape water dialysis purification system. The system comprises a water intake pumping station, a water distribution well and a cloth filter tank, water taken by the water intake pumping station is conveyed into the water distribution well through a water inlet pipe of the water distribution well, the water inlet pipe of the water distribution well is connected with PAC and PAM pipelines, sewage is distributed into the cloth filter after being subjected to first flocculation and sedimentation in the water distribution well, PAM is added into a water outlet pipe of the water distribution well, pollutants in water are further subjected to flocculation and sedimentation in a flocculation and sedimentation section of the cloth filter, and the pollutants in the water are subjected to secondary flocculation and sedimentation. The sewage is filtered by the fiber rotary disc filter after two times of flocculating settling, and the filtered clear water can be discharged, so that the sewage is treated, the load of the fiber rotary disc filter is effectively reduced in the process, and the efficient treatment process of the sewage is ensured; sludge generated in the operation process of the system is collected and then filtered, so that the sludge produced by the system is treated.

The invention discloses a chicken infectious anemia subunit vaccine composition as well as a preparation method and application thereof. The vaccine composition contains a mixture of CIAV (Chicken Infectious Anemia Virus) VP1 and VP2 proteins, the mixture of the VP1 and VP2 proteins is prepared by performing in-vitro renaturation on VP1 inclusion body proteins by using a gradient dialysis method, adding pre-purified VP2 proteins in the dialysis process to promote the recovery of key conformation epitopes of the VP1 proteins, and then gradually removing a denaturing agent to obtain the VP1 and VP2 protein mixture. And refolding the VP1 protein to obtain the protein. The soluble VP2 protein is used as a molecular chaperone to recover the VP1 protein from the inclusion body. According to the VP2 protein assisted synergistic refolding strategy, the key conformation epitope of the VP1 protein is recovered by using the natural function of the VP2 protein. Subsequently, the immunogenicity and protective efficacy of the refolded VP1 and VP2 protein mixture are evaluated, and an economic and effective technical means is provided for preventing and controlling chicken infectious anemia.

The present teachings generally include devices, systems, kits, and methods related to containers for a liquid solution intended for transport into a patient's body—e.g., via an intravenous (IV) treatment, a dialysis treatment, and the like. A container of the present teachings may be structurally configured to be relatively easy to lift and handle, transport, and / or use. Moreover, a container of the present teachings may be sized and shaped to promote grouping of multiple containers together into a predetermined group shape, which can be beneficial for packaging, handling, and / or transport. To this end, a container of the present teachings may include substantially planar sidewalls and a base featuring a connector that projects downwardly along a z-axis no further than terminal ends of sidewalls disposed adjacent to the base, where a cross-section of the container approximates a polygon to promote the grouping of multiple containers together for packaging and transport.

The invention relates to the technical field of blood purification, and particularly discloses an integrated blood purification pipeline consumable device which comprises a main body bracket, and an artery pipeline assembly, a dialysis filter, a vein pipeline assembly, a pre-flushing piston assembly, a liquid inlet tank assembly and a liquid outlet tank assembly which are mounted on the main body bracket. The key core problem solved by the invention is to integrate treatment consumable pipelines and integrate a plurality of auxiliary function modules, so that the operation convenience of medical staff is greatly improved on the premise of ensuring treatment; by configuring an automatic pre-flushing function, a heparin injection function, a quantitative system and the like, the operation process of ultralight portable blood purification equipment matched with the device can be simplified, the size and the weight of the equipment are reduced, and the equipment is suitable for wider and more complex application environments; the method can be used for early treatment of severe wounded persons in modern wars, emergency supplement of conventional dialysis treatment patients, disaster relief without traditional dialysis conditions, self-treatment of patients in emergencies and the like, and has wide application prospect and practical value.

The invention discloses a folic acid modified active oxygen response type sodium alginate nano-carrier and application thereof, and the preparation method comprises the following steps: firstly synthesizing-Se-Se-FA: stirring dicyclohexylcarbodiimide, 4-dimethylaminopyridine, dimethyl sulfoxide / pyridine, a double-selenium fragment and folic acid at room temperature for 18-22 hours in an argon environment; and carrying out acetone precipitation, centrifugation, washing, rotary evaporation concentration and freeze-drying. The preparation method comprises the following steps: preparing an ALG-Se-FA carrier, stirring sodium alginate, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and hydroxysuccinimide in a 2-morpholinoethanesulfonic acid buffer solution, adding DMSO, dissolving a double-selenium fragment and a-Se-Se-FA fragment in DMSO and deionized water, adding the dissolved double-selenium fragment and-Se-Se-FA fragment into a system, stirring, dialyzing, and freeze-drying to obtain the product. According to the carrier, a double-selenium bond ROS response unit and folic acid targeting molecules are introduced through covalent bonds, astaxanthin can be efficiently entrapped and protected, and after the carrier is stable in gastrointestinal environment and reaches a colitis disease part, high ROS level can be responded, and intelligent drug slow release is achieved through folic acid receptor targeting.

The application provides a quartz sand acid washing waste liquid resource treatment method, and belongs to the field of industrial waste water treatment, and comprises the following steps: adding magnetic composite seeds to the quartz sand acid washing waste liquid, and performing magnetic separation after stirring treatment; adding soluble potassium salt to the treated waste liquid to recover potassium fluosilicate; treating the filtrate through diffusion dialysis to obtain recovered acid and dialysis residual liquid; the diffusion dialysis treatment adopts an asymmetric membrane, the asymmetric membrane has a physical gradient of one side being a dense structure and the other side being a loose structure, and the dense structure side is in contact with the waste liquid; and adding calcium oxide or calcium hydroxide to the dialysis residual liquid for deep treatment and calcium recovery. The application provides a quartz sand acid washing waste liquid resource treatment method which is low in treatment cost, high in resource recovery rate and friendly to the environment, and realizes the differentiated resource recovery of the quartz sand acid washing waste liquid.

The utility model relates to the field of medicine preparation, in particular to dialysis powder stirring and drying equipment. Comprising a supporting frame which is an installation carrier composed of a plurality of trusses, a bearing frame is arranged between lower trusses, the middle trusses are higher than the trusses on the two sides, a drying cabin is fixed between the higher trusses in the middle of the supporting frame, the bottom of the drying cabin is connected with the top of the bearing frame, a cavity is formed in the inner wall of the drying cabin, and a protruding rod is rotationally arranged on one side of the outer portion of the drying cabin. A control electric box is arranged on one side of the supporting frame. By means of the reverse spiral design of the large mixing propeller and the small mixing propeller, it is guaranteed that materials are comprehensively and carefully mixed in the drying bin, caking is broken, and the uniformity and quality of final products are improved; through cooperation of the hot oil circulating system and the heater, efficient heat transfer and utilization are achieved, and energy waste is reduced; the hot oil circulation not only ensures the uniform distribution of the temperature in the drying cabin, but also prolongs the service life of the heater.

To provide a jelly composition containing spherical adsorptive carbon for improving uremic symptoms and delaying initiation of dialysis of chronic renal failure patients, which has more improved medication compliance than existing therapeutic agents.SOLUTION: The jelly composition contains spherical adsorptive carbon as an active ingredient, a gelling agent, a thickener, and spherical adsorptive carbon containing distilled water.SELECTED DRAWING: Figure 2

The present application relates to the technical field of vaccine production, in particular to a preparation method of a Sapindus saponin veterinary vaccine adjuvant, comprising: determining the limit concentration of Sapindus saponin with a hemolysis rate lower than 5% and preparing the vaccine adjuvant; determining the limit concentration of Sapindus saponin with a hemolysis rate lower than 5% against red blood cells by spectrophotometry; preparing the vaccine adjuvant by dialysis; and the vaccine adjuvant contains soybean lecithin and cholesterol in a weight ratio of 1:1. The present application first determines the safe use concentration of Sapindus saponin through a standard hemolysis experiment, ensures that the hemolysis rate of the prepared adjuvant meets the safety requirements, and avoids adverse reactions after injection; at the same time, the present application uses soybean lecithin and cholesterol as raw materials, and prepares the nano-liposome adjuvant embedding Sapindus saponin by dialysis, which does not require complex process operation, has low preparation cost, and has safety and practicability, and can effectively assist the vaccine to induce the body to produce stronger immune response and improve the protection effect of the vaccine.

The invention discloses a Streptomyces rochei D74 homogeneous polysaccharide and a preparation method and application thereof.The Streptomyces rochei D74 homogeneous polysaccharide is obtained by smashing Streptomyces rochei D74 mycelia obtained through liquid fermentation, then conducting water extraction, concentration, alcohol precipitation and deproteinization to obtain crude polysaccharide, and further conducting ion-exchange chromatography, dialysis and gel column chromatography purification to obtain the Streptomyces rochei D74 homogeneous polysaccharide. The method is simple and efficient, and the obtained streptomyces homogeneous polysaccharide remarkably inhibits proliferation of human gastric cancer cells SGC-7901 by inducing tumor cell apoptosis; meanwhile, immune cells RAW264.7 can be activated, the phagocytic ability and the nitric oxide (NO) release ability of the immune cells RAW264.7 can be improved, and the polysaccharide can become a potential polysaccharide drug for treating human liver cancer.

The application belongs to the technical field of dental antibacterial materials, and discloses a kind of nanometer composite antibacterial coating for dental material and preparation method thereof.Method: monomer modified arginine, monomer N-isopropyl acrylamide, monomer methyl hexyl acrylate, initiator azobisdimethylamino propanamide hydrochloride, dispersing agent cetyltrimethylammonium bromide and crosslinking agent N,N-methylene bis(acrylamide) are dissolved in water, and the reaction is carried out under protective atmosphere, dialysis, to obtain nanogel dispersion;The nanogel dispersion is mixed with the nanometer zinc oxide dispersion to obtain a nanogel composite zinc oxide antibacterial coating, and a coating is formed after coating.The nanometer composite antibacterial coating for dental material has excellent retention capacity and antibacterial performance.

The invention discloses a preparation method and application of a mitochondrial targeting polypeptide modified carbon quantum dot probe, and relates to the technical field of nano biological materials and fluorescence imaging.The preparation method comprises the steps that citric acid and urea are dissolved in a dimethyl sulfoxide solution, mixed, heated, filtered, added with ethyl alcohol, centrifuged and freeze-dried, and carbon quantum dots are obtained; adding an MES buffer solution and an activating agent, reacting the polypeptide at room temperature, heating, reacting, centrifuging, dialyzing and freeze-drying to obtain polypeptide modified carbon quantum dots; the carbon quantum dots are synthesized from bottom to top, and the preparation method is simple. After polypeptide modification, the product has an obvious mitochondrial targeting effect, and the product is good in biocompatibility, so that the product can be used for imaging and dynamic tracking of living organelles. The probe developed by the invention shows obvious application potential in key cell events such as mitochondrial dynamic monitoring and the like.

The invention discloses a water-soluble silk fibroin with a random crimp / Silk I structure as a main structure as well as a preparation method and application of the water-soluble silk fibroin. The silk fibroin product is characterized in that in a protein secondary structure, the total content of random curls and Silk I structures exceeds 85%, and the proportion of Silk I in the whole crystal structure is not lower than 75%; the product can be directly dissolved in water at room temperature to form a stable clarified solution with the concentration not lower than 5%, and is not gelatinized after being stored at 4 DEG C for 90 days. The preparation method comprises the following steps: degumming and cleaning the mulberry silk raw material; the method comprises the following steps: carrying out short-time (less than or equal to 20 minutes) high-temperature dissolution by adopting a multi-element solution dissolution system with a specific ratio, and then carrying out dialysis purification at a low temperature by taking the conductivity (lt, 10 [mu] S / cm) of a dialysis external liquid and the concentration (lt, 50 ppm) of calcium ions as double end-point standards. The directional regulation and control of the silk fibroin structure are realized through the accurate control of the whole process, and the obtained product has excellent water solubility, storage stability and biological safety, and can be widely applied to the fields of drug delivery, 3D biological printing, medical beauty filling, tissue engineering and the like.

The present disclosure relates to 1-(2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)acetyl)-4- hydroxypyrrolidine-2-carboxamide derivatives and structurally related compounds of formula (I) as VHL inhibitors for the treatment of e.g. anemia (e.g. chronic anemia or anemia associated with chronic kidney disease, dialysis or cancer chemotherapy), ischemia, stroke or injury to the cardiovascular system during ischemia, or for enhancing wound healing, reducing scarring or enhancing angiogenesis or arteriogenesis.

The invention relates to the technical field of biological materials, and discloses electrical stimulation LDH hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a zinc salt, a vanadium salt and urea in water in a nitrogen atmosphere to obtain a precursor solution; the precursor solution is subjected to a hydrothermal reaction, and ZnV-LDH is obtained; under stirring, gradually dropwise adding methacrylic anhydride into the gelatin solution, and heating for reaction; adding preheated water into the reaction liquid to stop the reaction; dialyzing and purifying the reaction liquid, pre-freezing, and freeze-drying to obtain hydrogel; and adding ZnV-LDH into the hydrogel, and carrying out ultrasonic mixing, so as to obtain the electrical stimulation LDH hydrogel. Through the synergistic effect of the ZnV-LDH and the hydrogel, the electrical stimulation LDH hydrogel disclosed by the invention has electrical activity and can generate potential change in response to external stimulation; under ultrasonic stimulation, concentration-dependent electrical response can be generated, the response has periodicity and stability, and osteogenic differentiation and cell mechanical properties can be promoted to the maximum extent.

This invention discloses a method for preparing a polycitric acid-based adhesive composite coating. The method includes the following steps: Step 1: After melting citric acid, polyethylene glycol and 1,8-octanediol are added, acrylic acid is added dropwise and stirred, and the mixture is dissolved, purified by dialysis, and then freeze-dried under vacuum to obtain a double-bonded polycitric acid ester prepolymer; Step 2: Polylysine is mixed with the double-bonded polycitric acid ester prepolymer to obtain a polycitric acid ester composite solution; Step 3: The polycitric acid ester composite solution is dropwise added to the surface of a substrate and thermosetting to obtain a polycitric acid-based adhesive composite coating. This invention also discloses the applications of the polycitric acid-based adhesive composite coating. This invention, by adding acrylic acid to the polycitric acid prepolymer system to generate a double-bonded polycitric acid ester prepolymer, and by adding polylysine to form a polycitric acid ester composite solution, forms a polycitric acid-based adhesive composite coating with strong adhesion after thermosetting, which is applicable to the field of biodegradable biomedical materials technology.

Compounds, systems, kits, methods, and / or apparatuses may be operative to reduce amyloid beta (Aβ) peptide in a patient, including a central nervous system (CNS) of the patient and / or a periphery (non-CNS portion) of the patient. In some embodiments, a displacer fluid comprising a Aβ displacer may be introduced to the patient to bind to a blood protein, such as albumin, that binds Aβ (for instance, Aβ peptide or non-plaque Aβ) in the patient periphery. Binding of the displacer to the blood protein may facilitate more free Aβ peptide (for instance, Aβ monomers) in the periphery for clearance via natural processes, such as through the liver or kidneys, and / or artificial processes, such as dialysis. Increased removal of the free Aβ peptide in the periphery may ultimately lead to less Aβ peptide in the CNS, which may decrease Aβ plaque formation in Alzheimer's Disease (AD) patients. Other embodiments are described.

A spectroscopic detection system includes a sensor configured to reflect light of a first wavelength associated with a presence of a reference substance on the sensor and configured to reflect light of a second wavelength associated with a presence of a monitored substance on the sensor, wherein the monitored substance flows to the sensor from a circulating fluid. The spectroscopic detection system further includes a detector that has first and second channels for respectively receiving the light of the first and second wavelengths reflected from the sensor and one or more processors in electrical communication with the detector and configured to identify an excess condition of the monitored substance with respect to the circulating fluid based on a ratio of a second amount of the light of the second wavelength received at the detector to a first amount of the light of the first wavelength received at the detector.

The application relates to the field of triple-negative breast cancer treatment and relates to synthesis of an acid-responsive amphiphilic liposome and application of the acid-responsive amphiphilic liposome in tumor treatment. A chemotherapeutic drug, a phospholipid, cholesterol and a polyethylene glycolized lipid are dissolved in an organic solvent chloroform, vacuum rotary evaporation is carried out under certain temperature and rotation rate, a water phase is added for hydration, a polypeptide nanogold cluster solution is added for ultrasonic treatment, then crushing, molecular sieve screening, dialysis and ultrafiltration are carried out to obtain a pH-sensitive liposome; in the preparation process, the phospholipid spontaneously forms a kind of biological membrane-like phospholipid bilayer membrane vesicle in water, and the chemotherapeutic drug and the nanogold cluster are wrapped in the vesicle. The pH-sensitive liposome can target the triple-negative breast cancer tumor site through pH response, can improve the solubility of the chemotherapeutic drug, can realize high-efficiency treatment effect of the drug at a low dose, can obviously reduce the toxic side effect of the chemotherapeutic drug, and can realize effective treatment of the triple-negative breast cancer.

The present application relates to the technical field of food processing, and particularly relates to acetylated carrageenan with anti-inflammatory activity and a preparation method and application thereof, the preparation method comprising the following steps: step 1: carrageenan acidolysis, obtaining carrageenan powder with different molecular weights, and adding the carrageenan powder into formamide to obtain a mixed solution; step 2: placing the mixed solution in a reaction environment with a temperature of 40-60 DEG C to react; step 3: obtaining an acetylated carrageenan solution by reaction; step 4: adding anhydrous ethanol to precipitate, centrifuging to obtain the precipitate, resolubilizing with water, using a 500Da dialysis bag to dialyze with distilled water, and freeze-drying to obtain acetylated carrageenan. The present application has the beneficial effect that the preparation method of the acetylated carrageenan obtained by the above technical solution of the present application acetylates and modifies specific low-molecular-weight carrageenan, has the effects of reducing inflammation of low-molecular-weight carrageenan, improving the degree of acetyl substitution, promoting the biological activity of carrageenan and many other advantages, and can be produced industrially.

The utility model discloses a high-flatness electrodialysis clapboard, which relates to the technical field of electrodialysis and comprises a clapboard main body, a lower ion exchange membrane is fixedly connected to the inner wall of the clapboard main body, a dialysis net is movably connected to the top of the lower ion exchange membrane, and a splitting mechanism is arranged at the top of the clapboard main body. A positioning mechanism is arranged on the side face of the partition plate body, and the splitting mechanism comprises a splitting plate and a cross-shaped protrusion. According to the utility model, through the connection relation design of the splitting plate and the partition plate main body, the cross-shaped bulge is correspondingly inserted into the cross-shaped groove, the splitting plate can be mounted on the partition plate main body, and the splitting plate is pulled out in the direction far away from the partition plate main body, so that the splitting plate is dismounted; the dialysis net in the inner cavity of the partition plate body can be replaced, use by a user is facilitated, the problem that the whole structure needs to be replaced when the use effect of the dialysis net becomes poor is solved, and the maintenance cost is reduced.