1778 results about "Dialysis" patented technology

The invention relates to the technical field of dialysis detection, and particularly discloses a blood purification center dialysis water detection device which comprises a charging bin, an automatic sampling mechanism, a control operation table, detection equipment, a ground rail moving platform and a carrying mechanical arm. The automatic sampling mechanism can be stored in the charging bin, a height adjusting part and an automatic operation part are arranged in the automatic sampling mechanism, the height adjusting part can adjust the position and the height to enable the height adjusting part to be matched with the position of a detection valve of external filtering equipment, and the automatic operation part can execute operation to replace manual sampling operation. An automatic device is adopted to replace manual operation of medical staff to perform water quality detection sampling operation on the filter for hemodialysis, so that the overall detection efficiency is greatly improved, dangerous operation is remotely completed under the condition of no human intervention, the safety and health of the staff are effectively guaranteed, and the working efficiency is improved. And inaccurate detection or influence on normal operation of the whole dialysis water system caused by equipment failure is avoided.

The invention belongs to the technical field of medical cosmetology and plastic surgery, and particularly relates to a hydroxyapatite microsphere facial skin filling agent for injection and a preparation method thereof. Hydroxyapatite microspheres and sodium hyaluronate are uniformly mixed, a cross-linking agent is added, and cross-linked sodium hyaluronate-hydroxyapatite core-shell structure microsphere particles which take hydroxyapatite microspheres as cores and cross-linked sodium hyaluronate as shells and are of a soft-in-hard structure can be obtained through dialysis and particle grading. The cross-linked sodium hyaluronate is used as a core-shell structure, so that the hydroxyapatite is locked in the cross-linked sodium hyaluronate, agglomeration is effectively avoided, the extrusion resistance can be well reduced by the soft-wrapped-hard core-shell structure, and the propulsive force is smaller. All the components in the hydroxyapatite microsphere facial skin filler for injection have better biocompatibility, so that the rejection of the filler in a body is reduced, and the skin problems of allergy, redness, swelling, small lumps and the like after injection and filling are effectively avoided.

The invention relates to the technical field of medical equipment, in particular to an anti-blocking device of chronic kidney disease dialysis equipment and an anti-blocking method thereof.The anti-blocking device comprises a dialysis bag, a placement tube and a drainage bag, and a second catheter is communicated between the drainage bag and the placement tube; the placing pipe and the second guide pipe are both communicated with anti-blocking assemblies, each anti-blocking assembly comprises a circulation cavity and a driving box, a driving cavity is formed in each driving box, a driven assembly is rotationally connected into each driving cavity, an opening assembly is arranged on the side, located in the corresponding circulation cavity, of each driven assembly, and a conveying assembly is arranged on the side, located in the corresponding driving cavity, of each driven assembly; the driven assembly is sleeved with a turbine assembly, a transmission gear is arranged between the driven assembly and the turbine assembly, and a spring for driving the driven assembly and the turbine assembly through the transmission gear is arranged between the turbine assembly and the driven assembly. The blockage condition in the guide pipe is sensed through the rotating speed of the turbine assembly, and the defibrinase for digesting protein clots is automatically conveyed when the guide pipe is blocked, so that the aim of automatically treating the blockage of the guide pipe is fulfilled.

The invention discloses a medicine dialysis dry powder production whole process intelligent supervision method, and belongs to the technical field of medicine production intelligent monitoring. The method comprises the following steps: collecting a raw material purity parameter, a mixing process microscopic parameter and a finished product performance index parameter in real time through a sensor array module; the data processing module performs preprocessing and feature extraction on the collected parameters; the deep learning model module carries out training based on the preprocessed parameters to generate a dynamic ratio adjustment scheme; the control module controls the raw material conveying amount of the production equipment according to the adjustment scheme; and the closed loop feedback module feeds back the adjusted finished product performance index parameters to the deep learning model module to form a dynamic optimization closed loop. The method further comprises an abnormity early warning step and a model iteration step, the whole-process intelligent supervision of the medicine dialysis dry powder production process is realized, the proportion can be automatically adjusted according to the purity fluctuation of the raw materials, the stable product quality is ensured, the production efficiency is improved, and the manual intervention requirement is reduced.

The utility model provides an acid etching liquid recycling device which comprises a circulating box, an inner cavity is formed in the circulating box, a partition plate is fixedly connected to the middle end of the bottom of the inner cavity, a cleaning mechanism is arranged on the front side of the circulating box, and a dismounting mechanism is arranged on the left side of the inner cavity. An impurity filtering layer is arranged on the left side of the inner cavity through a dismounting mechanism, a degerming layer is fixedly connected to the lower portion of the dismounting mechanism, a guiding layer is fixedly connected to the lower portion of the degerming layer, an infusion pump is fixedly connected to the position, located on the left side of the partition plate, of the bottom of the inner cavity, and the input end of the infusion pump communicates with an input pipe; by arranging the cleaning mechanism, the top of the impurity filtering layer can be scraped and swept, large particles remaining on the top of the impurity filtering layer are pushed to the top of the connecting plate and fall into the inner side of the macromolecule dialysis layer through the leakage groove, and the situation that the filtering effect of the impurity filtering layer is affected due to excessive accumulation of the large particles is avoided.

The invention discloses a hemodialysis patient home management system based on an informatization technology, and relates to the technical field of medical informatization, and the system comprises the following components: a data collection and analysis module which collects the information of vital signs, dialysis data, diet intake and living habits of a patient in real time through a wearable device and an intelligent home sensor, according to the method, a decision tree algorithm is utilized to predict dialysis requirements and complication risks, a linear regression model is combined to predict dialysis effects, scientificity and effectiveness of a dialysis scheme are effectively improved, a Q-learning algorithm is introduced to dynamically adjust the dialysis scheme, and the dialysis efficiency is improved. The treatment strategy is continuously optimized according to the real-time feedback of the patient, the comfort of the patient is improved, the long-term effect of dialysis treatment is remarkably improved, the workload of medical staff is relieved, and the self-management ability of the patient is enhanced.

The invention discloses a corn peptide for dispelling effects of alcohol and protecting liver as well as a preparation method and application thereof, and belongs to the technical field of biological peptide extraction. The preparation method comprises the following steps: crushing and sieving corn, dissolving the corn in deionized water, adjusting the pH value to be alkaline, and performing ultrasonic-assisted extraction to obtain corn homogenate; centrifuging, taking supernate, adjusting the pH to be neutral, centrifuging, adding an ethanol solution with the mass fraction of 10%, standing, carrying out continuous flow centrifugation, suspending precipitates in distilled water, dialyzing in a dialysis bag, and freeze-drying to obtain crude corn protein; the preparation method comprises the following steps: preparing an aqueous solution, carrying out variable-temperature treatment, adjusting the pH value to be alkaline, adding trypsin and alkaline protease, carrying out enzymolysis, repeating the enzymolysis twice, and after the enzymolysis is finished, carrying out heating enzyme deactivation, centrifugation, sediment discarding, ultrafiltration, centrifugation, supernatant taking and spray drying to obtain the corn peptide. The corn peptide can remarkably shorten the drunkenness time and sobering time of mice and reduce the drunkenness duration, and has good effects of dispelling the effects of alcohol and protecting the liver.

The invention relates to a preparation method of a microwave-assisted synthesized near-infrared electrochemical luminescence gold nanocluster and application of the gold nanocluster in miRNA (micro Ribonucleic Acid) detection. The preparation method comprises the following steps: under a stirring condition, adding a gold source and alkali into a Met solution to obtain a mixed solution, carrying out microwave irradiation reaction, and carrying out solid-liquid separation to obtain a Met-Au NCs solution; the preparation method comprises the following steps: activating a Met-Au NCs solution by using EDC and NHS, adding a DNA solution, mixing, and dialyzing to obtain a Met-Au NCs-DNA compound, namely the near-infrared electrochemical luminescence gold nanocluster. Compared with Au NCs prepared by a common mild method, the Met-stable Au NCs prepared by a microwave-assisted method has the advantage that the fluorescence and electrochemical luminescence efficiency at 835 nm is improved. The invention also provides a'signal closing 'ECL (electron cyclotron ligand) biosensor for high-sensitivity detection of the miRNA-107 (MicroRNA-107), and a method for detecting the miRNA-107 (MicroRNA-107). The sensor is simple to operate and good in repeatability, and has important scientific significance and application value for clinical early diagnosis of cancers.

The utility model discloses a dialysis phototherapy device and system, the dialysis phototherapy device comprises a base, a heat dissipation disc bracket, a metal heat dissipation disc, a phototherapy lamp set and an operation panel, the heat dissipation disc bracket is arranged on the top of the base; the metal radiating disc is mounted at the top of the radiating disc bracket, radiating fins are arranged at the bottom of the outer side of the metal radiating disc, a circular lamp strip groove is formed in the top of the outer side of the metal radiating disc, a circuit board is arranged at the top in the metal radiating disc, and a radiator is arranged at the lower part in the metal radiating disc; the phototherapy lamp set comprises an outer side lamp strip, an inner side lamp strip and a bottom lamp panel which are connected with the circuit board, a groove-shaped lampshade is arranged above the phototherapy lamp set, and the shape and the position of the groove-shaped lampshade are matched with those of the lamp strip grooves; and the dialysis tube is mounted in the groove of the groove-shaped lampshade through the dialysis tube mounting hole. The dialysis treatment device can enhance the dialysis treatment effect, contributes to accelerating metabolism and helping the body to discharge wastes and toxins, and is reasonable in structure, small in occupied area, convenient to operate, low in temperature and safe and reliable to use.

The invention discloses a digital full-period monitoring and evaluating system for the internal fistula function of a uremia patient, and relates to the technical field of medical monitoring. By integrating a multi-mode sensor, intelligent data processing and cloud analysis technologies, comprehensive, accurate and real-time monitoring of the internal fistula function is realized. The system comprises a data acquisition unit, a data transmission unit, an intelligent processing terminal, a cloud server, a user interaction unit and a distributed storage unit, and can measure multi-dimensional physiological parameters such as blood flow velocity, blood flow volume and blood flow pressure and obtain the endovascular microstructure and elastic characteristics. And the cloud server executes multi-modal data fusion analysis, generates an early warning signal, and triggers alarms of different levels through a hierarchical early warning strategy. According to the system, the precision and comprehensiveness of internal fistula function monitoring are improved, the complication risk is reduced, and powerful technical support is provided for dialysis treatment of uremia patients.

The present invention provides a hemodialysis concentrate and a preparation method thereof, belonging to the technical field of pharmaceutical preparations, the hemodialysis concentrate includes liquid A and liquid B; liquid A includes sodium chloride, potassium chloride, magnesium chloride, calcium chloride and citric acid; liquid B includes sodium bicarbonate; the method for preparing liquid A is: sodium chloride, potassium chloride, calcium chloride and magnesium chloride are added to dialysis water, and the feed is fed once, stirred evenly and then filtered in a circulation manner; after the quality inspection is qualified, citric acid is added for secondary feeding, pH=1.5~1.7 is controlled, stirred and circulated, and liquid A is obtained after the citric acid is tested and qualified; the method for preparing liquid B is: sodium bicarbonate is added to dialysis water, stirred evenly and then filtered in a circulation manner, and liquid B is obtained after the quality inspection is qualified. The present invention uses citric acid as the acid solution of liquid A, adopts secondary feeding when preparing liquid A, adjusts the addition order of the liquid preparation raw materials, and controls the temperature and pH value, so as to prepare a hemodialysis concentrate with high stability and strong quality and safety.

The present invention provides a method for preparing a fluorescent sensor array for detecting heavy metal ions, the method comprising: mixing a cetylpyridinium chloride solution with a sodium hydroxide solution, then performing water bath ultrasound, purifying with dichloromethane, and then dialyzing with a dialysis bag to obtain a CPC-CDs solution; adding heavy metal ion solutions of different concentrations to CPC-CDs / XO sensing solutions under two groups of pH environments to obtain a fluorescent sensor array. Also provided is an application for detecting heavy metal ions Cr 6+ , Fe 2+ , Fe 3+ , and Hg 2+ The present invention simplifies the array construction steps by adjusting the pH environment of the system, and effectively improves the lack of affinity between carbon dots and heavy metal ions by adding xylenol, and can simultaneously detect multiple metal ions (Cr 6+ , Fe 2+ , Fe 3+ , and Hg 2+ ), with high sensitivity and good selectivity, is used for the detection of heavy metals in the environment.

The utility model discloses a heat dissipation system and a metal heat dissipation disc used for an auxiliary dialysis phototherapy device, the auxiliary dialysis phototherapy device comprises a base, a phototherapy lamp set and an operation panel, the heat dissipation system comprises the metal heat dissipation disc and a heat dissipation device, the metal heat dissipation disc comprises a heat dissipation disc main body and a heat dissipation disc outer ring, and the heat dissipation disc main body and the heat dissipation disc outer ring are arranged on the base. The heat dissipation disc body is arranged in the heat dissipation disc outer ring and integrally formed with the heat dissipation disc outer ring, a round lamp strip groove is formed in the front face of the heat dissipation disc body, a middle fin structure is arranged at the position, at the lamp strip groove, of the back face of the heat dissipation disc body, and the heat dissipation disc body is arranged above the base through the heat dissipation disc bracket. The operation panel is installed above the heat dissipation disc body, the heat dissipation disc outer ring protrudes out of the edges of the heat dissipation disc bracket and the operation panel, and an outer edge fin structure is arranged on the back face of the heat dissipation disc outer ring. The auxiliary dialysis phototherapy device can be greatly cooled, the temperature of blood in the dialysis tube is prevented from rising, and the dialysis treatment effect is enhanced.

The invention provides a composite film based on a two-dimensional covalent organic framework as well as a preparation method and application of the composite film. The preparation method comprises the following steps: pouring a 2, 4, 6-triformyl phloroglucinol solution into the bottom layer of a container, slowly dropwise adding deionized water as a buffer solution, and dropwise adding a diamine monomer 2, 5-diaminobenzene sulfonic acid solution on the uppermost layer; under a static condition, carrying out a synthetic reaction at room temperature; after the reaction is finished, sucking out the upper-layer nanosheet by using a suction tube, and filling the upper-layer nanosheet into a treated dialysis bag; the synthesized nanosheet is subjected to dialysis treatment in deionized water, a TpPa-SO3H nanosheet is obtained, and a covalent organic framework nanosheet solution is obtained; taking a carbon nanotube, adding an organic solvent, and carrying out ultrasonic dissolution to obtain a carbon nanotube solution; a carbon nanotube solution and a covalent organic framework nanosheet solution are taken to be mixed and subjected to uniform ultrasonic treatment, the mixture is assembled to a nylon membrane through vacuum pressurization, drying is conducted, and the two-dimensional covalent organic framework composite membrane is obtained and has good performance and can be well applied to seawater desalination or dye separation.

The invention belongs to the field of conducting polymers, and discloses a method for synthesizing an n-type conducting polymer poly (benzodifuran diketone) (PBFDO). The method comprises the following steps: in an inert atmosphere, dispersing benzodifuran diketone (BFDO), S8 and organic alkali in an organic solvent, then carrying out a heating reaction, and after the reaction is finished, pouring into a dialysis bag for dialysis to obtain the n-type conductive polymer PBFDO. The conductivity of the prepared n-type conductive polymer poly (benzodifuran diketone) (PBFDO) is as high as 2300 S cm <-1 >.

The blood purification device comprises a blood purifier, a downward extending plate and a plurality of dialysis pipelines, a plurality of pipeline connectors are installed on one side of the downward extending plate, liquid flowing grooves are formed in the pipeline connectors, the dialysis pipelines are inserted into the inner walls of the corresponding liquid flowing grooves, and the dialysis pipelines are connected with the downward extending plate through the liquid flowing grooves. A connector chuck is installed on the side wall of the dialysis pipeline, a bottom groove is formed in the bottom end of the pipeline connector, an annular inner groove is formed in the pipeline connector, and a check ring is fixedly connected to the inner wall of the annular inner groove; the sealing air bag expands and extrudes when the dialysis pipeline is connected with the pipeline connector, the connecting tightness and the sealing effect between the connector chuck and the bottom groove are enhanced, then blood leakage or air entering the pipeline is prevented, the actual blood amount participating in purification is kept, and the purification efficiency is prevented from being affected; air is prevented from entering a pipeline to form air embolism, and the risk that external bacteria infect blood is avoided.

The invention discloses chiral ionizable lipid nanoparticles and a preparation method thereof, and belongs to the technical field of biomedical materials. The chiral ionizable lipid nanoparticle comprises chiral amino acid derived lipid, ionizable lipid, auxiliary lipid, cholesterol, a phospholipid polyethylene glycol derivative and an RNA (Ribonucleic Acid) drug, the preparation method comprises the following steps: dissolving chiral amino acid derived lipid in methanol, respectively dissolving ionizable lipid, auxiliary lipid, cholesterol and phospholipid polyethylene glycol derivative in ethanol, and mixing to obtain a total lipid organic phase; dissolving an RNA drug in DEPC water to obtain an RNA aqueous solution, and mixing the RNA aqueous solution with an acidic buffer solution to obtain an RNA aqueous phase; quickly mixing the total lipid organic phase and the RNA water phase, and standing and incubating; adding the mixed solution into a 3500 Da dialysis bag, taking 1 * phosphate buffer solution (PBS, pH = 7.4) as an external water phase, and dialyzing to obtain the chiral ionizable lipid nanoparticles. The lipid nanoparticles provided by the invention can enhance the RNA uptake efficiency, and have good application prospects in the treatment of systemic inflammation and other diseases.

The invention belongs to the technical field of biochemistry, and particularly discloses dragon fruit residue polysaccharide as well as a preparation method and application thereof. The main structure of the pitaya residue polysaccharide is a repetitive unit composed of galactose and lactone galactose; in the monosaccharide composition of the pitaya residue polysaccharide, the content of galactose is 42 wt% or above. The pitaya pomace polysaccharide is prepared by taking pitaya pomace as a raw material and carrying out acidolysis, alcohol precipitation, dialysis and freeze drying on the pitaya pomace powder, and the pitaya pomace polysaccharide has high galactose content. A high-fat diet mouse model is used for testing the intestinal mucoprotein proportion, the oxidation resistance, the blood fat content and the like of the pitaya residue polysaccharide, and the result proves that the pitaya residue polysaccharide is beneficial to reducing blood fat, improving the oxidation resistance of the liver and maintaining the stability of mucus, has better protection and repair effects on intestinal barrier injury, and can be used for preparing the health-care food. The compound can be used for preparing medicines with the effects of reducing blood sugar, protecting liver, repairing intestinal barriers and the like.

The invention provides a preparation method of dendrobium huoshanense polysaccharide, which comprises the following steps: firstly, pretreating dendrobium huoshanense through steam explosion, then extracting water-soluble polysaccharide by using a hot water extraction method, then separating out the polysaccharide by using a low-temperature alcohol precipitation method, removing protein and pigment by using a Sevag method and a macroporous resin adsorption method, and then separating out the dendrobium huoshanense polysaccharide. Dialyzing the polysaccharide solution through a regenerated cellulose dialysis bag to remove substances with the molecular weight less than 2000Da, finally freeze-drying to obtain a dendrobium polysaccharide crude product, and further separating and purifying to obtain the refined dendrobium polysaccharide. In-vitro experiments show that the refined dendrobium polysaccharide has remarkable antioxidant activity and antitumor activity, and has a better application prospect in the fields of skin care and medicines.

The invention provides a hemodialysis room whole-process information management system based on active learning, and relates to the technical field of data processing, and the system comprises a feature construction module which is used for carrying out the structural processing of original dialysis information data, and extracting a plurality of feature factors related to the current physical state of a patient; the risk identification module is used for constructing a training sample group, performing supervised training by introducing a label, and generating a risk judgment model; the early warning generation module is used for generating a risk probability result and generating early warning information associated with the current patient identifier when the risk probability result reaches a preset risk threshold value; the scheduling module is used for dynamically adjusting the treatment scheduling sequence of the current patient according to the early warning information and recording the actual intervention effect after the treatment scheduling sequence is adjusted; the feedback learning module is used for endowing each feature factor with a weight value according to an actual intervention feedback result and feeding back the weight value to the risk identification module; according to the invention, autonomy and accuracy of information management are improved.

The invention discloses an EGCG-Cu complex, an EGCG-Cu-Cs nanoparticle, a preparation method of the EGCG-Cu complex, and an application of the EGCG-Cu-Cs nanoparticle. The preparation method comprises the following steps: mixing an aqueous solution of EGCG and an aqueous solution containing copper ions, adjusting the pH value, stirring for reaction, dialyzing or centrifuging, and freeze-drying to obtain the EGCG-Cu complex; the EGCG-Cu complex is dissolved in water, a chitosan solution is added, stirring reaction, centrifugal washing and freeze drying are carried out, and the EGCG-Cu-Cs nanoparticles are obtained. The EGCG-Cu complex and the EGCG-Cu-Cs nanoparticles prepared by the invention are uniform in size and good in dispersity, and have excellent xanthine oxidase inhibition effect and free radical scavenging effect.

The invention provides a preparation method for preparing hydrogel in a water phase and application of the hydrogel in tumor immune microenvironment evaluation ultrasonic detection, and relates to the technical field of organic synthesis. The preparation method comprises the following steps that chitosan is dissolved in water, a chitosan solution with a first preset concentration is prepared, and chitosan has carboxyl groups and amino groups; dissolving a condensing agent in water to prepare a reaction solution with a second preset concentration; mixing the chitosan solution with the reaction solution, adding glacial acetic acid, and reacting for preset time at preset temperature and preset pressure to obtain a mixed solution; carrying out dialysis treatment on the mixed solution to obtain hydrogel; wherein the ratio of the first preset concentration to the second preset concentration ranges from 10: 1 to 1: 1. According to the invention, the hydrogel with amido bonds is prepared in a water phase, and the hydrogel has the characteristics of low toxicity, good biocompatibility and good biodegradability.

The preparation method comprises the following steps: degreasing polygonatum cyrtonema leaf superfine powder, sequentially carrying out ultrasonic-assisted enzymolysis treatment on cellulase, xylanase, high-temperature-resistant alpha-amylase, papain and saccharifying enzyme, and carrying out alcohol precipitation, dialysis and vacuum freeze drying treatment to obtain the polygonatum cyrtonema leaf polysaccharide. The polygonatum cyrtonema leaf enzyme extraction crude polysaccharide is obtained; and separating the enzyme-extracted crude polysaccharide through a cellulose column, and purifying through a sephadex column to obtain the polygonatum cyrtonema leaf enzyme-extracted polysaccharide. Polysaccharide in polygonatum cyrtonema leaves is extracted through ultrasonic-assisted compound enzyme, single pure polysaccharide is obtained through alcohol precipitation, dialysis, cellulose column chromatography and gel column chromatography, and the purity can reach 99.86%; the obtained enzyme extraction polysaccharide has good anti-cancer activity, can significantly inhibit proliferation of breast cancer cells and colorectal cancer cells, has the characteristics of good biocompatibility, strong specificity, low toxic and side effects and the like, and has wide application prospects.

The invention discloses an adjusting and fixing device for dialysis tubes, and relates to the technical field of medical equipment.The adjusting and fixing device comprises a winding and fixing mechanism and a connecting support installed on one side of the winding and fixing mechanism, an adjusting and fixing mechanism is arranged on one side of the winding and fixing mechanism, and a lifting support is arranged at the top of the adjusting and fixing mechanism; the winding fixing mechanism comprises a winding support, a shrinkage sliding groove is formed in the periphery of the interior of the winding support, a shrinkage sliding rod is fixedly installed in the shrinkage sliding groove, a shrinkage spring is fixedly installed in the middle of the shrinkage sliding rod, and shrinkage sliding sleeves are fixedly installed at the two ends of the shrinkage spring. The rotation of the first clamping support can be achieved, meanwhile, the limiting of the first clamping support can be achieved, and the rotation direction of the clamping rotating arm can be conveniently changed, so that the device is suitable for dialysis tubes with different spiral turns, and when the dialysis tubes are pulled, due to the fact that the dialysis tubes are spirally wound on the contraction arc-shaped plates, the dialysis tubes can be conveniently clamped. The phenomenon that the dialysis tube is damaged due to pulling can be avoided.

The present disclosure pertains to a media supply arrangement for supplying a medical treatment device with a medium, in particular for supplying an extracorporeal blood treatment device with a dialysis medium, wherein an air conditioning device for air conditioning of a medical treatment device coupled to the media supply arrangement is provided.

The invention discloses a self-adaptive hydrogel coupling agent as well as a preparation method and application thereof, belongs to the field of medical instruments, and particularly relates to a preparation method of the self-adaptive hydrogel coupling agent. The preparation method comprises the following steps: dissolving a main monomer, a functional monomer, a molecular weight regulator and a reinforcing filler in sterilized deionized water under dark and sterile conditions, carrying out a free radical polymerization reaction under the action of a persulfate solution and tetramethylethylenediamine, and carrying out dialysis and sterilization treatment to obtain the self-adaptive hydrogel coupling agent. The self-adaptive hydrogel coupling agent prepared by the invention eliminates tissue deformation caused by probe pressurization, significantly improves the accuracy of measurement of the actual distance of a target by ultrasound in an operation, and meanwhile, the self-adaptive hydrogel coupling agent is good in biocompatibility, can be sterile, is convenient to operate, and is suitable for open or endoscopic surgical wounds.

The invention provides a bacteriostatic and scale-inhibiting PE material and a preparation method thereof, and belongs to the technical field of high polymer materials, the preparation method comprises the following preparation steps: dissolving polyethylene in xylene, dissolving, adding perfluorohexylethylene and dicumyl peroxide, reacting, precipitating, washing, and drying to obtain perfluoro modified PE; the preparation method comprises the following steps: dissolving four-arm polyethylene glycol amine in a PBS buffer solution, adding 4-carboxyphenylboronic acid, EDC.HCl and NHS, carrying out a stirring reaction in a dark place, carrying out ultrafiltration and freeze drying to obtain PBA-PEG, dissolving the PBA-PEG in a Tris-HCl buffer solution, adding dopamine hydrochloride, and carrying out mixing, oxidation reaction, dialysis purification and drying to obtain a PBA-DA-PEG compound; the preparation method comprises the following steps: pre-mixing perfluorinated modified PE, mixing with an antioxidant and a compatibilizer, injecting the PBA-DA-PEG compound, continuously mixing, extruding, and carrying out water-cooling pelletizing to obtain the antibacterial and scale-inhibiting PE material. According to the PE material obtained by the invention, the antibacterial performance and the scale inhibition performance of the material can be improved at the same time.

The invention discloses a fluorescent probe for rapidly and sensitively detecting tetracycline antibiotics and a preparation method and application thereof.The preparation method comprises the steps that citric acid is dissolved in ultrapure water, polyethyleneimine is added under vigorous stirring till a reagent is completely dissolved, then a mixed solution is transferred into a high-pressure kettle for a hydrothermal reaction, and after natural cooling is conducted to the room temperature, the fluorescent probe is obtained; dialyzing the obtained solution through a dialysis bag to obtain a BCDs solution; europium chloride hexahydrate and trimellitic acid are ultrasonically dissolved in N, N-dimethylformamide, then the prepared BCDs solution is added and stirred, the stirred liquid is transferred into a high-pressure kettle for a solvothermal reaction, after the liquid is naturally cooled to the room temperature, a product is washed with absolute ethyl alcohol and then dried in a vacuum drying oven, and the BCDs / Eu-MOF probe is obtained. The method is suitable for detecting TCs in water and food such as milk and honey, and a simple, rapid and sensitive strategy is provided for visual field quantitative detection of TCs.

The invention discloses construction of a near-infrared fluorescent carbon dot based on metformin. The carbon dot is synthesized from metformin and an amino acid compound through a one-pot hydrothermal method. The preparation method comprises the following steps: mixing the metformin and the amino acid compound, dissolving in an alkaline solution, carrying out ultrasonic dissolution, transferring the solution into a polytetrafluoroethylene inner container, putting the inner container into a stainless steel high-pressure kettle, and carrying out heating reaction in a muffle furnace. After the reaction is finished and a reaction system is cooled to room temperature, taking out the solution and centrifuging to obtain supernate; and then putting the supernate into a dialysis bag for dialysis purification, and after dialysis is finished, freeze-drying the solution to obtain the carbon dots MACDs disclosed by the invention. The prepared carbon dot has excellent biocompatibility and optical property adjustability, retains the characteristic structure of metformin, has near-infrared fluorescence emission, and can realize disease diagnosis of organisms.

The invention relates to the technical field of phycocyanin extraction, in particular to a method for extracting phycocyanin by using a natural deep-eutectic solvent, NaDES is prepared by mixing a hydrogen bond binding donor and a hydrogen bond binding receptor in a fixed proportion, the NaDES component is an ingredient allowed to be added in cosmetic regulations, and when phycocyanin is extracted, the content of the NaDES component is reduced. The phycocyanin can be directly added into cosmetic preparation without complex purification and extraction solvent removal steps such as precipitation, centrifugation, dialysis, ion exchange chromatography and the like, the method is more environment-friendly and safer, the glycerol-glucose solvent can play a role in protecting phycocyanin, so that the structure of the phycocyanin is not easily damaged by light and heat, the storage stability is improved, and the application prospect is wide. Therefore, the technical problem that in the process of extracting phycocyanin by an existing phycocyanin extraction method, the used imidazole and pyridine ionic liquid has the defects of being difficult to degrade and toxic and causes influence on the body health of workers and the environment is solved.