989 results about "Dialysis" patented technology

The invention discloses a medicine dialysis dry powder production whole process intelligent supervision method, and belongs to the technical field of medicine production intelligent monitoring. The method comprises the following steps: collecting a raw material purity parameter, a mixing process microscopic parameter and a finished product performance index parameter in real time through a sensor array module; the data processing module performs preprocessing and feature extraction on the collected parameters; the deep learning model module carries out training based on the preprocessed parameters to generate a dynamic ratio adjustment scheme; the control module controls the raw material conveying amount of the production equipment according to the adjustment scheme; and the closed loop feedback module feeds back the adjusted finished product performance index parameters to the deep learning model module to form a dynamic optimization closed loop. The method further comprises an abnormity early warning step and a model iteration step, the whole-process intelligent supervision of the medicine dialysis dry powder production process is realized, the proportion can be automatically adjusted according to the purity fluctuation of the raw materials, the stable product quality is ensured, the production efficiency is improved, and the manual intervention requirement is reduced.

The invention discloses a corn peptide for dispelling effects of alcohol and protecting liver as well as a preparation method and application thereof, and belongs to the technical field of biological peptide extraction. The preparation method comprises the following steps: crushing and sieving corn, dissolving the corn in deionized water, adjusting the pH value to be alkaline, and performing ultrasonic-assisted extraction to obtain corn homogenate; centrifuging, taking supernate, adjusting the pH to be neutral, centrifuging, adding an ethanol solution with the mass fraction of 10%, standing, carrying out continuous flow centrifugation, suspending precipitates in distilled water, dialyzing in a dialysis bag, and freeze-drying to obtain crude corn protein; the preparation method comprises the following steps: preparing an aqueous solution, carrying out variable-temperature treatment, adjusting the pH value to be alkaline, adding trypsin and alkaline protease, carrying out enzymolysis, repeating the enzymolysis twice, and after the enzymolysis is finished, carrying out heating enzyme deactivation, centrifugation, sediment discarding, ultrafiltration, centrifugation, supernatant taking and spray drying to obtain the corn peptide. The corn peptide can remarkably shorten the drunkenness time and sobering time of mice and reduce the drunkenness duration, and has good effects of dispelling the effects of alcohol and protecting the liver.

The invention relates to a preparation method of a microwave-assisted synthesized near-infrared electrochemical luminescence gold nanocluster and application of the gold nanocluster in miRNA (micro Ribonucleic Acid) detection. The preparation method comprises the following steps: under a stirring condition, adding a gold source and alkali into a Met solution to obtain a mixed solution, carrying out microwave irradiation reaction, and carrying out solid-liquid separation to obtain a Met-Au NCs solution; the preparation method comprises the following steps: activating a Met-Au NCs solution by using EDC and NHS, adding a DNA solution, mixing, and dialyzing to obtain a Met-Au NCs-DNA compound, namely the near-infrared electrochemical luminescence gold nanocluster. Compared with Au NCs prepared by a common mild method, the Met-stable Au NCs prepared by a microwave-assisted method has the advantage that the fluorescence and electrochemical luminescence efficiency at 835 nm is improved. The invention also provides a'signal closing 'ECL (electron cyclotron ligand) biosensor for high-sensitivity detection of the miRNA-107 (MicroRNA-107), and a method for detecting the miRNA-107 (MicroRNA-107). The sensor is simple to operate and good in repeatability, and has important scientific significance and application value for clinical early diagnosis of cancers.

The invention discloses chiral ionizable lipid nanoparticles and a preparation method thereof, and belongs to the technical field of biomedical materials. The chiral ionizable lipid nanoparticle comprises chiral amino acid derived lipid, ionizable lipid, auxiliary lipid, cholesterol, a phospholipid polyethylene glycol derivative and an RNA (Ribonucleic Acid) drug, the preparation method comprises the following steps: dissolving chiral amino acid derived lipid in methanol, respectively dissolving ionizable lipid, auxiliary lipid, cholesterol and phospholipid polyethylene glycol derivative in ethanol, and mixing to obtain a total lipid organic phase; dissolving an RNA drug in DEPC water to obtain an RNA aqueous solution, and mixing the RNA aqueous solution with an acidic buffer solution to obtain an RNA aqueous phase; quickly mixing the total lipid organic phase and the RNA water phase, and standing and incubating; adding the mixed solution into a 3500 Da dialysis bag, taking 1 * phosphate buffer solution (PBS, pH = 7.4) as an external water phase, and dialyzing to obtain the chiral ionizable lipid nanoparticles. The lipid nanoparticles provided by the invention can enhance the RNA uptake efficiency, and have good application prospects in the treatment of systemic inflammation and other diseases.

The invention provides a hemodialysis room whole-process information management system based on active learning, and relates to the technical field of data processing, and the system comprises a feature construction module which is used for carrying out the structural processing of original dialysis information data, and extracting a plurality of feature factors related to the current physical state of a patient; the risk identification module is used for constructing a training sample group, performing supervised training by introducing a label, and generating a risk judgment model; the early warning generation module is used for generating a risk probability result and generating early warning information associated with the current patient identifier when the risk probability result reaches a preset risk threshold value; the scheduling module is used for dynamically adjusting the treatment scheduling sequence of the current patient according to the early warning information and recording the actual intervention effect after the treatment scheduling sequence is adjusted; the feedback learning module is used for endowing each feature factor with a weight value according to an actual intervention feedback result and feeding back the weight value to the risk identification module; according to the invention, autonomy and accuracy of information management are improved.

The invention discloses a self-adaptive hydrogel coupling agent as well as a preparation method and application thereof, belongs to the field of medical instruments, and particularly relates to a preparation method of the self-adaptive hydrogel coupling agent. The preparation method comprises the following steps: dissolving a main monomer, a functional monomer, a molecular weight regulator and a reinforcing filler in sterilized deionized water under dark and sterile conditions, carrying out a free radical polymerization reaction under the action of a persulfate solution and tetramethylethylenediamine, and carrying out dialysis and sterilization treatment to obtain the self-adaptive hydrogel coupling agent. The self-adaptive hydrogel coupling agent prepared by the invention eliminates tissue deformation caused by probe pressurization, significantly improves the accuracy of measurement of the actual distance of a target by ultrasound in an operation, and meanwhile, the self-adaptive hydrogel coupling agent is good in biocompatibility, can be sterile, is convenient to operate, and is suitable for open or endoscopic surgical wounds.

The invention provides a bacteriostatic and scale-inhibiting PE material and a preparation method thereof, and belongs to the technical field of high polymer materials, the preparation method comprises the following preparation steps: dissolving polyethylene in xylene, dissolving, adding perfluorohexylethylene and dicumyl peroxide, reacting, precipitating, washing, and drying to obtain perfluoro modified PE; the preparation method comprises the following steps: dissolving four-arm polyethylene glycol amine in a PBS buffer solution, adding 4-carboxyphenylboronic acid, EDC.HCl and NHS, carrying out a stirring reaction in a dark place, carrying out ultrafiltration and freeze drying to obtain PBA-PEG, dissolving the PBA-PEG in a Tris-HCl buffer solution, adding dopamine hydrochloride, and carrying out mixing, oxidation reaction, dialysis purification and drying to obtain a PBA-DA-PEG compound; the preparation method comprises the following steps: pre-mixing perfluorinated modified PE, mixing with an antioxidant and a compatibilizer, injecting the PBA-DA-PEG compound, continuously mixing, extruding, and carrying out water-cooling pelletizing to obtain the antibacterial and scale-inhibiting PE material. According to the PE material obtained by the invention, the antibacterial performance and the scale inhibition performance of the material can be improved at the same time.

The invention relates to the field of medical informatics, and provides a hemodialysis multi-mode risk closed-loop control system. Comprising a multi-source data acquisition module used for acquiring heterogeneous data in a dialysis process in real time; the space-time fusion engine module is used for carrying out space-time alignment and feature extraction of cross-modal data on the heterogeneous data by adopting a graph neural network architecture to generate a fusion feature vector; the dynamic risk prediction module is used for constructing a multi-dimensional risk assessment system based on the fusion feature vector, carrying out probability prediction on multiple risk types and outputting a prediction result; and the intelligent intervention control module evaluates the risk level according to the prediction result output by the dynamic risk prediction module, and generates an intervention strategy through a reinforcement learning algorithm. According to the invention, the timeliness and accuracy of intervention response are improved, and the incidence rate of dialysis complications is reduced.

Provided herein is a method of using digital twins for medical diagnosis, prediction, and / or prognosis of a disease or condition, such as diagnosis, prediction, and / or prognosis of one or more cancers, organ-specific age prediction, predicting of female aging, predicting hospital-acquired infection, predicting dialysis time series, predicting diabetes and complications, predicting pregnancy and child outcome, predicting heart failure, predicting myopia, predicting vision in anti-VEGF treatment, or any combination thereof. A system and non-transitory computer-readable storage medium configured for performing the method is also disclosed.

The invention discloses a process method for preparing high-spinning nano pyrite through physical field-chemical method coupling regulation and control, which comprises the following steps: dissolving bovine serum albumin in deionized water, adding an iron source, uniformly mixing, adjusting the pH value of the solution to 10.0-11.0, adding a sulfur source, and uniformly mixing, thereby obtaining the high-spinning nano pyrite. Carrying out a coupling regulation reaction of a physical field and a chemical method on the reaction system under the protection of inert gas, and then dialyzing and purifying to prepare the high-spin-state FeS2 nanosheet. The chemical method comprises one or more of a coprecipitation method, a solvothermal method and a hydrothermal method; the physical field comprises one or more of an alternating magnetic field, a static magnetic field and a rotating magnetic field. Through coupling regulation and control of a physical field and a chemical method, accurate conversion of the FeS2 nanosheet from a low spinning state to a high spinning state is realized, chemical doping can be effectively avoided, natural biological suitability of FeS2 is reserved, and the method has a good clinical conversion application prospect.

The invention relates to the crossing field of computer technology and edge calculation, and discloses a blood purification equipment real-time control method based on edge calculation. According to the method, multi-modal real-time physiological parameters, historical dialysis data and a current treatment target are fused through a local edge calculation unit, an individualized body fluid dynamic response prediction model is constructed, and an ultrafiltration rate instruction is optimized and generated within a millisecond level; the system comprises a multi-mode sensor array, a historical data storage module, a task planning interface, an edge computing unit and an ultrafiltration pump controller. According to the application, the hemodynamic state is accurately maintained, the risk of hypotension is remarkably reduced, and the treatment safety and individualization level are improved.

The method comprises the following steps: dissolving lipoic acid and a drug in an organic solvent to form a homogeneous solution, dropwise adding deionized water while stirring, then adding a reducing agent, initiating lipoic acid polymerization and drug co-assembly in situ at 20-40 DEG C to form a drug-loaded micelle solution, and carrying out freeze drying on the drug-loaded micelle solution to obtain the nano-preparation drug based on polylipoic acid. And dialyzing and purifying to obtain the nano preparation medicine based on polylipoic acid. The preparation method is characterized in that lipoic acid has dual characteristics of a drug carrier matrix and a dynamic crosslinking monomer, carrier synthesis and efficient drug encapsulation are synchronously realized through one-step in-situ polymerization-co-assembly, and the technical bottleneck that a traditional nano-carrier needs pre-synthesis and step-by-step drug loading is broken through. The method has the following practicability: (1) the process is simple and efficient, complex equipment is not needed, and reaction conditions are mild; (2) the drug loading performance is excellent, and the particle size is uniform and adjustable (50-300 nanometers); (3) a polylipoic acid skeleton endows the nano-drug preparation with environmental responsiveness, and intelligent drug release can be realized; and (4) the method is suitable for hydrophobic drugs and compound preparations. The method provides a high-load, high-stability and stimuli-responsive nanocrystallization solution for hydrophobic drug delivery, and has application value in the field of nano-medicines.

The invention relates to the technical field of intelligent monitoring, and particularly discloses an intelligent monitoring method and system for hemodialysis patient complications, and the method comprises the following steps: S1, carrying out the fusion to form a multi-modal feature set, S2, constructing an individualized risk feature map, S3, generating complication risk probability distribution, S4, calculating an individualized risk threshold value, and S5, generating an intervention suggestion sequence. The method comprises the following steps: acquiring physiological parameters of a hemodialysis patient and operation parameters of dialysis equipment, identifying a coupling relationship between the parameters, constructing an individualized risk characteristic spectrum, predicting a characteristic change trend, matching the characteristic change trend with a historical complication mode, calculating an individualized risk threshold to trigger early warning, generating targeted intervention suggestions, and monitoring an effect. According to the system, the accuracy and timeliness of hemodialysis complication monitoring are effectively improved, the complication occurrence rate is reduced, the workload of medical staff is relieved, and the safety and effectiveness of hemodialysis treatment are improved.

The invention provides a radix tetrastigme polysaccharide and application thereof in a medicine for treating diabetic retinopathy. The radix tetrastigme polysaccharide is prepared by the following steps: deproteinizing a water extract of radix tetrastigme by using CaCl2, depigmenting by using activated carbon, performing column chromatography, eluting by using a NaCl solution, merging and collecting eluent components, concentrating under reduced pressure, dialyzing by using a dialysis bag with an interception value of 0.5 KDa, and performing vacuum freeze drying. And performing further chromatography by using Chromdex 200PG sephadex gel, collecting the components, and performing freeze drying to obtain the homogeneous polysaccharide with the average molecular weight of 36.848 KDa. Meanwhile, pharmacological activity evaluation is carried out on the radix tetrastigme polysaccharide, it is found that the polysaccharide can reduce the free Fe < 2 + > level and reverse high glucose induced ARPE19 cell damage, and in addition, animal experiments also prove that the radix tetrastigme polysaccharide can reduce the DR rat retina Fe < 2 + > level and relieve diabetic retinopathy; the research can provide a scientific basis for research and development of a novel natural medicine radix tetrastigme polysaccharide for treating DR.

The utility model relates to the technical field of water pollution treatment, in particular to a landscape water dialysis purification system. The system comprises a water intake pumping station, a water distribution well and a cloth filter tank, water taken by the water intake pumping station is conveyed into the water distribution well through a water inlet pipe of the water distribution well, the water inlet pipe of the water distribution well is connected with PAC and PAM pipelines, sewage is distributed into the cloth filter after being subjected to first flocculation and sedimentation in the water distribution well, PAM is added into a water outlet pipe of the water distribution well, pollutants in water are further subjected to flocculation and sedimentation in a flocculation and sedimentation section of the cloth filter, and the pollutants in the water are subjected to secondary flocculation and sedimentation. The sewage is filtered by the fiber rotary disc filter after two times of flocculating settling, and the filtered clear water can be discharged, so that the sewage is treated, the load of the fiber rotary disc filter is effectively reduced in the process, and the efficient treatment process of the sewage is ensured; sludge generated in the operation process of the system is collected and then filtered, so that the sludge produced by the system is treated.

The invention relates to the field, and discloses a dialysis concurrent risk dynamic assessment system, which comprises a data acquisition module, a data processing module and a data processing module, the data preprocessing module is used for carrying out abnormal value detection and processing on the multi-source data by adopting an isolated forest algorithm, and filling missing values in the multi-source data through an Attention-GAN network; the feature fusion module is used for performing feature fusion on the cleaned multi-source data by using a cross-modal attention fusion algorithm to generate a comprehensive feature vector; the model construction module is used for constructing a ResNet-GRU hybrid model based on the comprehensive feature vector and introducing a dynamic feature attention mechanism; the risk assessment module is used for inputting to-be-assessed patient data into the ResNet-GRU hybrid model to obtain a risk assessment result; according to the invention, the timeliness and accuracy of evaluation are obviously improved.

The invention discloses a chicken infectious anemia subunit vaccine composition as well as a preparation method and application thereof. The vaccine composition contains a mixture of CIAV (Chicken Infectious Anemia Virus) VP1 and VP2 proteins, the mixture of the VP1 and VP2 proteins is prepared by performing in-vitro renaturation on VP1 inclusion body proteins by using a gradient dialysis method, adding pre-purified VP2 proteins in the dialysis process to promote the recovery of key conformation epitopes of the VP1 proteins, and then gradually removing a denaturing agent to obtain the VP1 and VP2 protein mixture. And refolding the VP1 protein to obtain the protein. The soluble VP2 protein is used as a molecular chaperone to recover the VP1 protein from the inclusion body. According to the VP2 protein assisted synergistic refolding strategy, the key conformation epitope of the VP1 protein is recovered by using the natural function of the VP2 protein. Subsequently, the immunogenicity and protective efficacy of the refolded VP1 and VP2 protein mixture are evaluated, and an economic and effective technical means is provided for preventing and controlling chicken infectious anemia.

The present teachings generally include devices, systems, kits, and methods related to containers for a liquid solution intended for transport into a patient's body—e.g., via an intravenous (IV) treatment, a dialysis treatment, and the like. A container of the present teachings may be structurally configured to be relatively easy to lift and handle, transport, and / or use. Moreover, a container of the present teachings may be sized and shaped to promote grouping of multiple containers together into a predetermined group shape, which can be beneficial for packaging, handling, and / or transport. To this end, a container of the present teachings may include substantially planar sidewalls and a base featuring a connector that projects downwardly along a z-axis no further than terminal ends of sidewalls disposed adjacent to the base, where a cross-section of the container approximates a polygon to promote the grouping of multiple containers together for packaging and transport.

This disclosure is directed to medical systems and techniques to provide enhanced care to patients by implementing dialysis management. In one example medical system configured for dialytic treatments, a computing device may be configured to perform a risk assessment for a patient having an upcoming dialysis session based on impedance data. In other examples, the computing device may be configured to use the impedance data an accurately estimate fluid volume for controlling an amount of fluid to be removed during the dialysis session.

The invention relates to the technical field of blood purification, and particularly discloses an integrated blood purification pipeline consumable device which comprises a main body bracket, and an artery pipeline assembly, a dialysis filter, a vein pipeline assembly, a pre-flushing piston assembly, a liquid inlet tank assembly and a liquid outlet tank assembly which are mounted on the main body bracket. The key core problem solved by the invention is to integrate treatment consumable pipelines and integrate a plurality of auxiliary function modules, so that the operation convenience of medical staff is greatly improved on the premise of ensuring treatment; by configuring an automatic pre-flushing function, a heparin injection function, a quantitative system and the like, the operation process of ultralight portable blood purification equipment matched with the device can be simplified, the size and the weight of the equipment are reduced, and the equipment is suitable for wider and more complex application environments; the method can be used for early treatment of severe wounded persons in modern wars, emergency supplement of conventional dialysis treatment patients, disaster relief without traditional dialysis conditions, self-treatment of patients in emergencies and the like, and has wide application prospect and practical value.

The invention discloses a folic acid modified active oxygen response type sodium alginate nano-carrier and application thereof, and the preparation method comprises the following steps: firstly synthesizing-Se-Se-FA: stirring dicyclohexylcarbodiimide, 4-dimethylaminopyridine, dimethyl sulfoxide / pyridine, a double-selenium fragment and folic acid at room temperature for 18-22 hours in an argon environment; and carrying out acetone precipitation, centrifugation, washing, rotary evaporation concentration and freeze-drying. The preparation method comprises the following steps: preparing an ALG-Se-FA carrier, stirring sodium alginate, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and hydroxysuccinimide in a 2-morpholinoethanesulfonic acid buffer solution, adding DMSO, dissolving a double-selenium fragment and a-Se-Se-FA fragment in DMSO and deionized water, adding the dissolved double-selenium fragment and-Se-Se-FA fragment into a system, stirring, dialyzing, and freeze-drying to obtain the product. According to the carrier, a double-selenium bond ROS response unit and folic acid targeting molecules are introduced through covalent bonds, astaxanthin can be efficiently entrapped and protected, and after the carrier is stable in gastrointestinal environment and reaches a colitis disease part, high ROS level can be responded, and intelligent drug slow release is achieved through folic acid receptor targeting.

The invention belongs to the technical field of fluorescent probes, and particularly relates to a ratio fluorescent probe based on red / blue double-color carbon dots as well as a preparation method and application of the ratio fluorescent probe. The ratio fluorescent probe based on the red-blue double-color carbon dots is obtained by mixing a blue fluorescent carbon dot solution and a red fluorescent carbon dot solution according to the volume ratio of 6: 1, and the concentrations of the blue fluorescent carbon dot solution and the red fluorescent carbon dot solution are both 0.5 mg / mL; the blue fluorescent carbon dot solution is prepared by the following steps: adding deionized water into a mixed solution of citric acid and ethidene diamine, carrying out ultrasonic treatment, and then carrying out reaction centrifugation, filtration and dialysis to obtain blue fluorescent carbon dots; the red fluorescent carbon dot solution is prepared by adding deionized water and concentrated sulfuric acid into o-phenylenediamine, L-cysteine and boric acid, carrying out ultrasonic treatment, reacting, centrifuging, filtering, dialyzing and freeze-drying. The ratio fluorescent probe based on the red / blue double-color carbon dots can accurately detect the concentration of quercetin in the concentration range of 0-30.0 [mu] mol / L.

The invention provides a preparation method of fish gelatin polysaccharide from fish gelatin, which is characterized in that fish maw is subjected to degreasing, proteolysis, alcohol precipitation and column separation to obtain the fish gelatin polysaccharide. According to the application, the crushed cod gelatin is taken as a raw material, the fish gelatin polysaccharide is prepared from the crushed cod gelatin through a specific enzymolysis process in combination with graded purification technologies such as alcohol precipitation, chromatographic column separation and dialysis, glycosaminoglycan in the prepared fish gelatin polysaccharide contains chondroitin sulfate which accounts for 90% of glycosaminoglycan 7, and the repairing effect on the wound of the zebra fish is obvious.

The application provides a quartz sand acid washing waste liquid resource treatment method, and belongs to the field of industrial waste water treatment, and comprises the following steps: adding magnetic composite seeds to the quartz sand acid washing waste liquid, and performing magnetic separation after stirring treatment; adding soluble potassium salt to the treated waste liquid to recover potassium fluosilicate; treating the filtrate through diffusion dialysis to obtain recovered acid and dialysis residual liquid; the diffusion dialysis treatment adopts an asymmetric membrane, the asymmetric membrane has a physical gradient of one side being a dense structure and the other side being a loose structure, and the dense structure side is in contact with the waste liquid; and adding calcium oxide or calcium hydroxide to the dialysis residual liquid for deep treatment and calcium recovery. The application provides a quartz sand acid washing waste liquid resource treatment method which is low in treatment cost, high in resource recovery rate and friendly to the environment, and realizes the differentiated resource recovery of the quartz sand acid washing waste liquid.

The utility model relates to the field of medicine preparation, in particular to dialysis powder stirring and drying equipment. Comprising a supporting frame which is an installation carrier composed of a plurality of trusses, a bearing frame is arranged between lower trusses, the middle trusses are higher than the trusses on the two sides, a drying cabin is fixed between the higher trusses in the middle of the supporting frame, the bottom of the drying cabin is connected with the top of the bearing frame, a cavity is formed in the inner wall of the drying cabin, and a protruding rod is rotationally arranged on one side of the outer portion of the drying cabin. A control electric box is arranged on one side of the supporting frame. By means of the reverse spiral design of the large mixing propeller and the small mixing propeller, it is guaranteed that materials are comprehensively and carefully mixed in the drying bin, caking is broken, and the uniformity and quality of final products are improved; through cooperation of the hot oil circulating system and the heater, efficient heat transfer and utilization are achieved, and energy waste is reduced; the hot oil circulation not only ensures the uniform distribution of the temperature in the drying cabin, but also prolongs the service life of the heater.

To provide a jelly composition containing spherical adsorptive carbon for improving uremic symptoms and delaying initiation of dialysis of chronic renal failure patients, which has more improved medication compliance than existing therapeutic agents.SOLUTION: The jelly composition contains spherical adsorptive carbon as an active ingredient, a gelling agent, a thickener, and spherical adsorptive carbon containing distilled water.SELECTED DRAWING: Figure 2

The present application relates to the technical field of vaccine production, in particular to a preparation method of a Sapindus saponin veterinary vaccine adjuvant, comprising: determining the limit concentration of Sapindus saponin with a hemolysis rate lower than 5% and preparing the vaccine adjuvant; determining the limit concentration of Sapindus saponin with a hemolysis rate lower than 5% against red blood cells by spectrophotometry; preparing the vaccine adjuvant by dialysis; and the vaccine adjuvant contains soybean lecithin and cholesterol in a weight ratio of 1:1. The present application first determines the safe use concentration of Sapindus saponin through a standard hemolysis experiment, ensures that the hemolysis rate of the prepared adjuvant meets the safety requirements, and avoids adverse reactions after injection; at the same time, the present application uses soybean lecithin and cholesterol as raw materials, and prepares the nano-liposome adjuvant embedding Sapindus saponin by dialysis, which does not require complex process operation, has low preparation cost, and has safety and practicability, and can effectively assist the vaccine to induce the body to produce stronger immune response and improve the protection effect of the vaccine.

The present invention discloses a small molecule inhibitor nanoparticle based on polyamino acid, which is composed of polyethylene glycol b ‑Poly(4‑boron‑L‑phenylalanine‑ What Specifically, polyethylene glycol- b ‑Poly(4‑boron‑L‑phenylalanine‑ What A solution of a β-L-tyrosine (L-tyrosine) copolymer and a drug solution were added dropwise to a buffer solution. After the addition was complete, dialysis was performed to produce polyamino acid-based small molecule inhibitor nanoparticles. These nanoparticles exhibited excellent drug co-encapsulation and stability, and rapidly released the drug in an acidic / hydrogen peroxide / enzyme environment, achieving synergistic killing of leukemia cells and significantly inhibiting leukemia cell infiltration in organs such as the bone marrow, spleen, and liver. The nanomedicine designed in this invention exhibits high drug loading efficiency, excellent stability, and trigger-responsiveness. Furthermore, this intelligent nanomedicine boasts a simple structure, adjustable drug combinations, high safety, and strong synergistic efficacy, making it readily applicable to cancer treatment.

The invention discloses a Streptomyces rochei D74 homogeneous polysaccharide and a preparation method and application thereof.The Streptomyces rochei D74 homogeneous polysaccharide is obtained by smashing Streptomyces rochei D74 mycelia obtained through liquid fermentation, then conducting water extraction, concentration, alcohol precipitation and deproteinization to obtain crude polysaccharide, and further conducting ion-exchange chromatography, dialysis and gel column chromatography purification to obtain the Streptomyces rochei D74 homogeneous polysaccharide. The method is simple and efficient, and the obtained streptomyces homogeneous polysaccharide remarkably inhibits proliferation of human gastric cancer cells SGC-7901 by inducing tumor cell apoptosis; meanwhile, immune cells RAW264.7 can be activated, the phagocytic ability and the nitric oxide (NO) release ability of the immune cells RAW264.7 can be improved, and the polysaccharide can become a potential polysaccharide drug for treating human liver cancer.

The application belongs to the technical field of dental antibacterial materials, and discloses a kind of nanometer composite antibacterial coating for dental material and preparation method thereof.Method: monomer modified arginine, monomer N-isopropyl acrylamide, monomer methyl hexyl acrylate, initiator azobisdimethylamino propanamide hydrochloride, dispersing agent cetyltrimethylammonium bromide and crosslinking agent N,N-methylene bis(acrylamide) are dissolved in water, and the reaction is carried out under protective atmosphere, dialysis, to obtain nanogel dispersion;The nanogel dispersion is mixed with the nanometer zinc oxide dispersion to obtain a nanogel composite zinc oxide antibacterial coating, and a coating is formed after coating.The nanometer composite antibacterial coating for dental material has excellent retention capacity and antibacterial performance.