21 results about "Polyamino acid" patented technology

This application provides a method for preparing pH-responsive polyamino acid drug-loaded nanoparticles based on sarcosine and their application. Sar-NNCA, L-lysine-NCA, and L-phenylalanine-NCA are dissolved in anhydrous DMF and polymerized under argon protection with a hexamethyldisilazine initiator to obtain a polyamino acid block copolymer Sar-NNCA. 80 -Lys(Cbz) n -Phe 10 The crude product was deprotected under HBr / acetic acid and loaded with DOX to obtain Sar. 80 -Lys n -Phe 10 -DOX. This application describes the preparation of a pH-responsive polymer nanoplatform, Sar, by encapsulating doxorubicin in polysarcosine-polylysine-polyphenylalanine nanoparticles via Schiff base bonds. 80 -Lys n -Phe 10 -DOX is used for tumor treatment. These polyamino acid nanoparticles are spherical with an average particle size of approximately 200 nanometers, exhibiting pH-responsive properties, excellent cellular uptake capacity, and anti-tumor effects. In vitro experiments show that Sar... 80 -Lys n -Phe 10 The carrier material exhibits excellent biocompatibility. The newly synthesized Sar... 80 -Lys n -Phe 10 -DOX nanomicelles show promise as a drug delivery system for cancer treatment.

The present application relates to the preparation method of carboxyl endocyclic anhydride and the preparation product. The preparation method of compound of formula (II) comprises the following steps: reacting compound of formula (I) with a cyclization reagent to generate compound of formula (II) and acid, and using an epoxide compound as an acid scavenger. The present application is a new synthesis method of carboxyl endocyclic anhydride, which has the advantages of low cost, low requirement for reagents, site and equipment, mild conditions, wide substrate application range, high functional group tolerance, recyclable solvent and other high value-added by-products in the synthesis route, less waste liquid discharge, easy scale-up, high industrial and academic value, and the like, and can greatly promote the rapid large-scale production and application of polyamino acid, polyhydroxy acid (polyester), polymercaptan acid (polythioester) and the like.

This invention discloses an essential oil nanoemulsion based on amphiphilic polyamino acids, its preparation method, and its applications, relating to the field of emulsion preparation technology. The preparation method of the essential oil nanoemulsion includes: grafting amino acids with hydrophobic residues onto polyaspartic acid to synthesize amphiphilic polyamino acids; mixing the amphiphilic polyamino acids with essential oils uniformly to obtain an essential oil nanoemulsion with good stability; this invention also provides applications of the essential oil nanoemulsion in food, cosmetics, or pharmaceutical preparations. This invention, by grafting amino acids with hydrophobic residues onto polyaspartic acid to form amphiphilic polyamino acids; using the amphiphilic polyamino acids as emulsifiers to emulsify essential oils, and preparing essential oil nanoemulsions through a spontaneous emulsification method, not only improves the water solubility and stability of essential oils but also reduces their volatility and irritating odor, while also possessing good biocompatibility and biodegradability, expanding the applications of essential oils in the food, daily chemical, and pharmaceutical fields.

This disclosure provides a dimer amino acid compound, a cell division inhibitor comprising the dimer amino acid compound, and a composition comprising the dimer amino acid compound or the cell division inhibitor.

This invention relates to a polyamino acid-based in-situ cartilage regeneration porous gel scaffold and its preparation method. Phenylboronic acid ester is esterified and linked with polyethylene glycol-modified Kartogenin to obtain phenylboronic acid ester-modified PEGKGN. The PEGKGN modified with phenylboronic acid ester is then grafted onto the side chains of polyamino acids with allyl polyethylene glycol to obtain a graft copolymer PLBPKA. The graft copolymer PLBPKA is blended with small molecules of Kartogenin and a silk fibroin solution to form a drug-loaded self-assembly network under shear force. Finally, the polyamino acid-based in-situ cartilage regeneration porous gel scaffold is constructed through ultraviolet light crosslinking and freeze-phase separation, which is a differentially released drug hydrogel scaffold. Compared with existing technologies, the scaffold of this invention has good biocompatibility and biocontrollable degradation, and can rapidly release drugs in inflammatory environments to promote stem cell migration; while in normal physiological environments, it slowly releases drugs to promote the differentiation of stem cells into cartilage. Therefore, it can promote in-situ regeneration of articular cartilage in the absence of exogenous stem cells.

This invention relates to a method for improving vanadium leaching rate and vanadium extraction through pretreatment of vanadium-containing steel slag. The pretreatment includes the following steps: S1, mixing vanadium-containing steel slag with water, adding organic polyphosphonic acid compounds and anionic polyamino acid salts, and ball milling to obtain a primary slurry; S2, subjecting the primary slurry to magnetic separation to obtain magnetic and non-magnetic slurries; S3, introducing CO2 into the non-magnetic slurry for reaction, followed by gravity separation to obtain a light slurry enriched with CaCO3 and a heavy slurry enriched with vanadium; S4, subjecting the vanadium-rich heavy slurry to a dissolution reaction with an ammonium halide aqueous solution to obtain a calcium-containing liquid phase and a vanadium-rich solid phase. Vanadium extraction is achieved by carbonate leaching of the vanadium-rich solid phase. This invention significantly improves the vanadium leaching rate (>92%) by adding organic polyphosphonic acid compounds and anionic polyamino acid salts as grinding aids during ball milling, promoting the efficient release and enrichment of vanadium-containing minerals, and combining this with magnetic separation for iron removal.

This invention relates to a polyamino acid exchange chromatography medium based on end-group immobilization, its preparation method, and its application. The preparation method includes the following steps: dispersing macroporous polysaccharide microspheres in a solvent to obtain a medium suspension; adding epichlorohydrin to the medium suspension and mixing thoroughly; adding sodium hydroxide solution to the medium suspension and stirring to obtain an epoxidized macroporous polysaccharide medium; immersing the epoxidized macroporous polysaccharide medium in an aqueous solution of polyanionic amino acids and stirring to promote the diffusion of polyanionic amino acids within the microspheres; adding sodium hydroxide solution and sodium borohydride solution to the mixture and stirring to obtain the polyamino acid exchange chromatography medium based on end-group immobilization. Compared with existing technologies, this invention utilizes end-group immobilized polyamino acid modification to prepare a macroporous cation exchange chromatography medium, significantly improving the protein adsorption capacity and rate of the chromatography medium.

This invention discloses a highly efficient and environmentally friendly additive, its preparation method, and its application in crude coal gas absorption and oil-water separation. The invention prepares a polyamino acid block copolymer by polymerization of tyrosine and N(ε)-benzyloxycarbonyl lysine as monomers. This polyamino acid block copolymer is then compounded with isotridecyl alcohol polyoxyethylene ether to prepare a composite additive. By changing the molecular chain length of the polyamino acid block copolymer and the compounding ratio of isotridecyl alcohol polyoxyethylene ether, this composite additive achieves high pH applicability while ensuring environmental friendliness, thus enabling efficient and clean crude coal gas absorption and efficient oil-water separation.

The present invention relates to a cationic biopolymer containing a betaine-derived portion, particularly a betaine quaternized poly(amino acid). The present invention also relates to a personal care composition, particularly a hair care composition, containing a cationic biopolymer containing a betaine-derived portion, and also to the use of a cationic biopolymer containing a betaine-derived portion in a personal care composition, particularly as a conditioning agent and / or cationic surfactant.

The present application relates to the field of fabric antibacterial material, in particular to a fabric photo-activated coupling antibacterial finishing agent material and a preparation method and application thereof. The fabric photo-activated coupling antibacterial finishing agent is used for fabric antibacterial finishing, and no other reagent is needed in the finishing process, the reaction condition is mild, the energy consumption is low, the branched polyamino acid antibacterial material can be finished on the surface of the fabric through ultraviolet light irradiation, excellent and durable antibacterial performance is given to the fabric, only N2 by-product is produced in the reaction process, and the environment is friendly. In addition, the photo-activated coupling reaction rate is fast, the efficiency is high, the process is easy to control, and the requirement for the processing equipment is not high. The fabric photo-activated coupling antibacterial finishing agent can be applied to the fabric through impregnation or spraying, and then subjected to light treatment, is suitable for efficient and rapid large-scale antibacterial finishing application of the fabric, is easy to integrate into the existing production process of the fabric, and is beneficial to actual transformation application.

The application discloses a kind of bioactive polyamino acid nanocomposites, preparation method and purposes, by condensation reaction synthesis hyaluronic acid-block-poly amphiphilic block copolymer, by hydrophobic, electrostatic, metal coordination etc. Interaction covers CD73 small molecule inhibitor APCP and PD1 / PD-L1 inhibitor S7911, preparation HA@APCP / S7911.HA@APCP / S7911 is enriched in tumor area by EPR effect, under the joint action of hyaluronidase and low pH in tumor area, realize the release of APCP and S7911 in tumor tissue.APCP is inhibited CD73 enzyme activity, restores the metabolism and activity of NK cell, starts NK cell immune response;S7911 is inhibited after release in tumor tissue PD-L1 and PD-1 binding, blocks immune checkpoint and starts T cell immunity, combined with radiotherapy to improve antitumor immune response, amplify the range of effective immune response, for promoting the combined effect of radioimmunotherapy provides a new way of thinking.

This invention discloses an acid corrosion inhibitor for carbon steel, its preparation method, and its application, belonging to the field of chemical corrosion protection technology. The invention uses Mannich base as the main agent and sulfur-containing polyamino acids as synergists, mixed with a solvent. Addressing the technical problems of existing acid corrosion inhibitors, such as increased costs due to high concentrations, and the presence of hazardous chemicals, costly surfactants, and foaming components in their formulations, this invention uses a small-molecule Mannich base and a long-chain sulfur-containing polyamino acid to construct a structure with multiple adsorption sites (N, O, and benzene ring adsorption sites on the Mannich base molecule and S, N, and O adsorption sites on the sulfur-containing polyamino acid molecular chain) and strong adsorption capacity (S has strong electronegativity). This allows for the formation of a robust and stable corrosion inhibitor adsorption film in high-temperature, strongly acidic environments, achieving excellent slow-release effects without pitting corrosion.

This invention discloses a self-suspending material for CO2 fracturing, its preparation method, and its application, belonging to the field of CO2 fracturing fluids. The self-suspending material for CO2 fracturing and its application utilize spherical quartz sand as a mechanical compressive strength support material, polyamino acids forming a hollow structure through water solubility, and a polymer obtained by polymerizing hydroxybenzoic acid and formaldehyde to protect the quartz sand, improve its compressive strength, and reduce its density. The polymer obtained by polymerizing hydroxybenzoic acid and formaldehyde is a rigid polymer that is insoluble in water and does not increase the viscosity of the fracturing fluid, effectively preventing reservoir damage. The unique hollow structure reduces the material's density, achieving a self-suspending effect. In obtaining the hollow structure, water is used as a template removal agent, effectively avoiding the corrosion problems to the quartz sand caused by using acids or alkalis to remove the template.

This invention discloses a star-shaped polyamino acid nanoparticle with long-cycle properties, its preparation method, and its applications, belonging to the field of biomedical technology. The nanoparticles of this invention have a star-shaped structure with a polyamide-amine dendritic macromolecule as the core and copolymerized amino acids as arms; the nanoparticles are first initiated by polyamide-amine as an initiator. N -Carboxylic acid ring anhydride and second N The nanoparticles are prepared by random copolymerization of anhydride monomers within a carboxylic acid ring in an organic solvent. The organic solvent is a mixture of a low-polarity haloalkane and a high-polarity amide or cyclic ether solvent in a volume ratio of 9:1. This preparation method is simple and efficient. This invention, by controlling the types of amino acids, the charge of the nanoparticles, and their topological structure, demonstrates that the star-shaped topology and glutamic acid / lysine side chains play a crucial role in achieving long-term cycling. These nanoparticles have broad application prospects in the preparation of therapeutic tumor drugs.

The application belongs to the technical field of biomedicine, and particularly relates to a biological tissue processing method for fluorescence in situ hybridization and application. The method comprises the following steps: contacting a biological tissue containing target nucleic acid with a nucleic acid probe to form a nucleic acid hybridization complex; and contacting the biological tissue with a reagent containing a cationic polymer; wherein the cationic polymer is at least one selected from a positively charged polypeptide, a protein or a polyamino acid, an amine polymer and a cationic polysaccharide. The application can enhance the stability of the hybridization signal after nucleic acid fluorescence in situ hybridization, and is beneficial to signal preservation in subsequent multi-modal staining, tissue transparentization processing and long-time preservation of the sample.

The application belongs to the technical field of mortar preparation, and particularly relates to a preparation method of modified cement-based polymer mortar, which comprises the following composition raw materials of the modified cement-based polymer mortar: nano aluminum sol, volcanic rock powder, Portland cement, palygorskite powder, modified fiber, industrial solid waste powder, styrene-acrylic emulsion, 3-chloro-2-hydroxypropane sulfonic acid ionization modified hyperbranched polyamino acid, fatty acid-based polyadduct, calcium borogluconate, sodium lauryl polyoxyethylene ether sulfate modified cross-linking type superabsorbent resin, fine sand, flocculating agent, accelerator and powdery water reducing agent. In the application, the flocculating agent and the accelerator are prepared, the flowability of the polymer cement-based mortar is sufficient to meet the construction requirements, the defects of the conventional polymer cement waterproof mortar, such as low compressive strength, large shrinkage rate and poor corrosion resistance, are solved, and the modified cement-based polymer mortar has the remarkable advantages of good impermeability, high water absorption rate, high bending strength and high bonding strength, and convenient construction.

The present invention relates to the field of polymer chemistry and more particularly to poly(amino acid) copolymers and uses thereof for drug delivery applications. In particular, the present invention concerns a linear copolymer comprising a polysarcosine block, pSar, containing from 15 to 99 sarcosine constitutional units and a poly(amino acid) block, pAA, containing from 8 to 120 amino acid constitutional units.

The present invention relates to a composition for treating keratin fibers, such as hair, comprising: (a) at least one hydroxy acid or a salt thereof; (b) at least one cationic polyamino acid; and (c) water, wherein the amount of the (b) cationic polyamino acid is 0.2% by weight or more, preferably 0.3% by weight or more, more preferably 0.5% by weight or more, and even more preferably 0.8% by weight or more, with respect to the total weight of the composition. The present invention enables the straightening of keratin fibers.

The present invention provides a chemical mechanical polishing slurry, comprising: silicon dioxide abrasive particles, a carboxyl-containing compound, and a polyamino acid compound. The chemical mechanical polishing slurry of the present invention has a relatively high silicon nitride removal rate and an extremely low tungsten removal rate.