203 results about "Polyamino acid" patented technology

In some aspects, the present disclosure provides a method for determining a polyamino acid descriptor associated with a biological state. The method can comprise removing technical variation from a proteomic dataset to generate a refined proteomic dataset, the technical variation arising from a predetermined non-biological factor, by training a neural network using a loss function. The loss function can be configured to increase a similarity between a first set of latent embeddings that are based on a first subset of polyamino acid descriptors in the proteomic dataset, wherein the first subset of polyamino acid descriptors are obtained from the same sample. The loss function can be configured to decrease the similarity between a second set of latent embeddings that are based on a second subset of polyamino acid descriptors in the proteomic dataset, wherein the second subset of polyamino acid descriptors are obtained from different samples.

The invention discloses a polyamino acid which has a structure as shown in the following formula (I), and R1, L1, L2, L3, R2, x, y and z are defined in the specification. The invention also discloses a method for preparing the polyamino acid and application of the polyamino acid as a biocompatible filling material. R1-(L1) x-(L2) y-(L3) z-R2 Formula (I)

The invention discloses a preparation method and application of a QS-21-polyamino acid nano vaccine, and belongs to the field of biomedical nano materials. The preparation method comprises the following steps: modifying gamma-PGA with phenylalanine ethyl ester (F) to obtain a polymer PF40 of which the F grafting rate is 40%; aiming at the characteristic that QS-21 is strongly combined with cholesterol, PF40 (PFC) grafted with cholesterol (C) is developed, and PFC wraps OVA and QS-21 through hydrophobic force to construct a nano vaccine OQPFC. The cholesterol on the PFC can reduce the combination of the QS-21 and the cholesterol on a cell membrane so as to reduce the biotoxicity of the QS-21, and the QS-21 loading efficiency of the nano vaccine is improved, so that a better treatment effect is achieved. The OQPFC can escape from lysosome through carboxyl protonation, and a large amount of QS-21 and OVA are released in cytoplasm, so that the synergistic cellular immune activation effect of the carrier adjuvant PFC and the saponin adjuvant QS-21 is realized.

The invention discloses a preparation method of an aperture-adjustable and metal-loaded graphite felt flow battery electrode, which comprises the following steps: (1) pretreatment and pore separation: mixing a graphite felt with an alkali solution, magnetically stirring, heating, cooling to room temperature, and treating again to obtain a pore separation material; (2) loading neodymium oxide: dipping the porous material in a solution containing neodymium salt and polyamino acid, heating, cleaning, and drying to obtain a neodymium oxide modified electrode material; (3) loading oxygen-deficient CoMnOx: coating the mixed slurry containing manganese and cobalt on an electrode plate, heating, cleaning and drying to obtain an oxygen-deficient CoMnOx loaded electrode; and (4) carrying out electro-deposition on the electrode loaded with the oxygen defect CoMnOx to obtain the novel bismuth-deposited graphite felt electrode. According to the electrode product obtained through the method, the energy efficiency is improved to 85% or above, and the stable cycle index for maintaining the energy efficiency can exceed 1440 times.

The invention belongs to the technical field related to tumors, and discloses a preparation method of self-developing embolism microspheres. Comprising the following steps: producing calcium alginate microspheres through cross-linking, obtaining polyelectrolyte hydrogel microspheres through electrostatic complexation, and obtaining the self-developing embolism microspheres through amino cross-linking. According to the invention, sodium alginate and polyamino acid are used as raw materials for preparation, so that the preservative is safe and non-toxic and has biodegradability, and the degradation product has no toxic or side effect on human body. The microspheres are prepared by adopting an electrostatic spraying method, organic solvents are not used, and the microspheres are green and environment-friendly and have no toxic residues.

The invention provides a high-temperature-resistant shale inhibitor as well as a preparation method and application thereof, and belongs to the technical field of petroleum drilling. Natural polymer polyamino acid and carbon-rich solid matter biochar are used as raw materials to prepare the shale inhibitor, the biochar has the advantages of being high in thermal stability, porous, rich in surface oxygen-containing functional groups and the like, the biochar is combined with polyamino acid, and by means of the chemical effect of the polyamino acid and the physical blocking effect of the biochar, the shale inhibitor is prepared. The shale inhibitor can inhibit shale hydration expansion at high temperature and has good hydration dispersibility, and the prepared shale inhibitor is green and environment-friendly and has excellent high temperature resistance.

The invention discloses hydrogel for repairing volumetric muscle defects and a preparation method of the hydrogel, and the hydrogel is prepared from oxidized dextran, an alcohol-polyamino acid-bilirubin polymer and 3, 3 '-dithio-bis (propionyl hydrazide) according to the weight ratio of (50-75): (4-20): 1. The alcohol-polyamino acid-bilirubin polymer is prepared from an alcohol-polyamino acid polymer and bilirubin in a weight ratio of (6-25): 1. The hydrogel prepared by the invention not only has good characteristics of pH / ROS responsiveness, relatively strong tissue adhesion, antibacterial property, oxidation resistance and relatively low cytotoxicity, but also can remarkably promote cell migration, proliferation, new angiogenesis and myoblast differentiation, promote recovery of muscle structures and motor functions after volumetric muscle defects, and improve the recovery rate of muscle tissues and motor functions after the volumetric muscle defects. The material is expected to become a novel bioactive material capable of promoting volume muscle defect repair, and has a good application prospect in clinical treatment of large-volume tissue defect regeneration.

Bioadhesive microparticle formulations and methods for preparation thereof are described. The microparticle formulation comprises cross linked poly-amino acid microparticles and may be delivered alone or may be used for delivery of an agent to a biological surface.

The invention discloses an additive for improving the compactness of concrete. Comprising the following components in parts by weight: 30-50 parts of a water reducing agent, 10-20 parts of an anti-permeability agent, 1-2 parts of an air entraining agent, 3-5 parts of a defoaming agent, 3-6 parts of a thickening agent and 3-5 parts of a dispersing agent. When the admixture is used for concrete, the compactness of the concrete is greatly improved, so that the compressive strength, the impermeability and the impact toughness of the concrete are improved. The combined use of polyethylene glycol-polyamino acid polymer and unsaturated amino polyoxyethylene ether in the admixture component improves the compressive strength of concrete, the combined use of sulfonated graphene and calcium formate improves the anti-permeability grade of concrete, and the combined use of alpha-olefin sodium sulfonate and allyl fatty alcohol polyoxyethylene ether improves the anti-permeability grade of concrete. The impact resistance of the concrete is improved.

The invention discloses an environment-friendly degradable plastic packaging bag and a preparation method thereof, belongs to the technical field of packaging bag preparation, and is used for solving the technical problem that the degradation capability and the mechanical property of an environment-friendly packaging bag in the prior art need to be further improved. According to the invention, the prepared carbonic acid bridged compact polyester is used as a main body skeleton to provide strength and film-forming property, silica acetal hybrid polysaccharide is introduced to form a compact and complex diffusion path inside and reduce gas and moisture permeation, and then active side chain polyamino acid is added to adjust interfacial compatibility and enhance structural stability, so that the film-forming property is improved. Through reasonable combination of the three components, the environment-friendly packaging bag keeps high tensile strength and tearing strength, meanwhile, the barrier property is remarkably improved, and gradual complete degradation is achieved in compost and soil environments.

The invention belongs to the technical field of medical polymer materials, relates to an amphiphilic block copolymer, a hydrogel material containing the amphiphilic block copolymer and a preparation method and application of the amphiphilic block copolymer, and particularly discloses a poly (2-ethyl-2-oxazoline)-polyamino acid block copolymer and a preparation method and application of a hydrogel material of the poly (2-ethyl-2-oxazoline)-polyamino acid block copolymer. The hydrogel material provided by the invention has excellent injectability, and the modulus and gelation temperature of a gel preparation can be adjusted by changing the molecular weight and concentration of the amphiphilic block copolymer, so that the hydrogel material adapts to different physiological environments, is applied to different indications, and can be applied to various diseases. Compared with other hydrogel in which the chemical structure of the polymer needs to be changed, the hydrogel is more convenient.

The invention provides ROS (reactive oxygen species) temperature double-sensitive injectable immunocompetence polyamino acid hydrogel and application thereof. The hydrogel can be independently gelled, the drug loading capacity is high and adjustable, and the hydrogel has temperature response, reactive oxygen species (ROS) response and immunostimulatory activity and can be injected. Through temperature response, the hydrogel is in a solution state under a low-temperature condition and is easy to inject, and the hydrogel can be quickly gelatinized under a body temperature condition to locally form a medicine storage cavern, so that the release time of the medicine is prolonged. Due to ROS response, the hydrogel achieves intelligent response to drug release by responding to a high-active oxygen microenvironment of a tumor site, and selective drug release is achieved. Due to the immunocompetence, the hydrogel can positively respond to a high-active-oxygen local microenvironment of a tumor site, R848 is released to stimulate the activity of host immune cells, and the anti-tumor effect is improved. The hydrogel can be simply and conveniently mixed with other treatment drugs for combined treatment, so that the tumor treatment effect is improved.

The present invention discloses a method for preparing a pore-adjustable and metal-loaded graphite felt flow battery electrode, comprising the following steps: (1) pretreatment and pore separation: mixing graphite felt with an alkaline solution, magnetically stirring, heating, cooling to room temperature, and re-treating to obtain a pore-separated material; (2) loading neodymium oxide: immersing the pore-separated material in a solution containing a neodymium salt and a polyamino acid, heating, cleaning, and drying to obtain a neodymium oxide-modified electrode material; (3) loading oxygen-deficient CoMnOx: applying a mixed slurry containing manganese and cobalt to an electrode sheet, heating, cleaning, and drying to obtain an oxygen-deficient CoMnOx-loaded electrode; and (4) electrodepositing the oxygen-deficient CoMnOx-loaded electrode to obtain a novel graphite felt electrode with bismuth deposition. The electrode product obtained by the method of the present invention has an energy efficiency of more than 85%, and the number of stable cycles at which the energy efficiency is maintained can exceed 1440 times.

Provided is a nanovaccine. The nanovaccine is prepared from the following starting materials: a sustained-release carrier, an antigen, an adjuvant, and a cationic component. The mass ratio of the sustained-release carrier to the antigen to the adjuvant to the cationic component is (1-30):1:(0.1-1):(0.05-0.5). The sustained-release carrier comprises sodium alginate. The antigen comprises at least one of a protein, a recombinant subunit, and a polypeptide. The cationic component comprises at least one of a calcium ion, a manganese ion, an aluminum ion, a polyamine, a basic amino acid, and a polyamino acid consisting of 2-30 basic amino acids. The nanovaccine comprises the sustained-release carrier sodium alginate, the antigen, the adjuvant, and the cationic component in a proper ratio. Sodium alginate is used as a sustained-release carrier and is promoted to form a network structure under the action of the cationic component, so as to encapsulate the antigen and the adjuvant, thereby forming a stable antigen-carrier-adjuvant nanoparticle gel. The nanovaccine can induce a stronger immune response and has good stability and good biocompatibility.

The invention provides a modified flow battery electrode capable of simultaneously improving activity and stability and a preparation method thereof.The method comprises the following steps that a carbon felt electrode material is added into a mixed solution of stannic chloride, manganous nitrate, melamine and urea, high-pressure treatment, ultrasonic cleaning and drying are conducted after magnetic stirring, and the modified electrode is obtained; adding the modified electrode into a mixed solution of nickel nitrate, melamine and urea, performing magnetic stirring, high-pressure treatment, ultrasonic cleaning and drying to obtain a modified electrode, immersing the modified electrode into a mixed solution of nickel nitrate, dopamine hydrochloride, polyamino acid, sodium citrate and ethanol, performing washing and drying, and then performing high-temperature treatment and pickling and drying to obtain an activated electrode; the voltage efficiency, the energy efficiency and the peak power density are greatly improved, the electrocatalytic activity of the flow battery is remarkably improved, and the stability of the electrode is also greatly improved while the electrocatalytic activity is improved.

The present invention relates to sulfur-containing lipid-polyamino acid conjugates of formula (I) and acceptable salts, stereoisomers and mixtures thereof. The invention also relates to self-assembled particles comprising these lipid / polyamino acid conjugates and optionally an active agent, and to compositions comprising lipid-polyamino acid conjugates or self-assembled particles comprising them. The invention also relates to the use of lipid-polyamino acid conjugates, self-assembling particles or compositions comprising them in medicine, cosmetics and diagnostics, and the use of lipid-polyamino acid conjugates of formula (I) as carriers.

The invention discloses an oligomeric amino acid dendritic macromolecular material as well as a preparation method and application thereof, and relates to the technical field of nano materials. The general formula of the oligomeric amino acid dendritic macromolecular material is TPE-(PEG) n-(Lys) x-(Arg) y, wherein TPE is a hydrophobic core, has an aggregation-induced emission characteristic, and can enhance the self-assembly capability and the tracing function of the nano-carrier; pEG is a connecting arm, so that the water solubility and biocompatibility of the material can be improved; lys is a branch skeleton and is a main construction unit of a dendritic macromolecule; arg is a functional terminal, guanidyl of Arg has strong positive charges, electrostatic binding with negatively charged nucleic acid can be promoted, and meanwhile cellular uptake can be enhanced possibly through the membrane penetration effect. The oligomeric amino acid dendritic macromolecular material gives consideration to stability, modifiability and targeting, provides a new scheme for small nucleic acid delivery, and is expected to have far-reaching influence in the fields of precise tumor treatment, gene therapy and multi-modal diagnosis and treatment.

The present invention discloses a small molecule inhibitor nanoparticle based on polyamino acid, which is composed of polyethylene glycol b ‑Poly(4‑boron‑L‑phenylalanine‑ What Specifically, polyethylene glycol- b ‑Poly(4‑boron‑L‑phenylalanine‑ What A solution of a β-L-tyrosine (L-tyrosine) copolymer and a drug solution were added dropwise to a buffer solution. After the addition was complete, dialysis was performed to produce polyamino acid-based small molecule inhibitor nanoparticles. These nanoparticles exhibited excellent drug co-encapsulation and stability, and rapidly released the drug in an acidic / hydrogen peroxide / enzyme environment, achieving synergistic killing of leukemia cells and significantly inhibiting leukemia cell infiltration in organs such as the bone marrow, spleen, and liver. The nanomedicine designed in this invention exhibits high drug loading efficiency, excellent stability, and trigger-responsiveness. Furthermore, this intelligent nanomedicine boasts a simple structure, adjustable drug combinations, high safety, and strong synergistic efficacy, making it readily applicable to cancer treatment.

Disclosed is a selenium-containing polyamino acid having a structure represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein A, B, D, E, m, n, and x are as defined in the description. Also disclosed is a pharmaceutical composition containing the selenium-containing polyamino acid or a pharmaceutically acceptable salt thereof. Also disclosed is a use of the selenium-containing polyamino acid or the pharmaceutically acceptable salt thereof, or the pharmaceutical composition containing the selenium-containing polyamino acid or the pharmaceutically acceptable salt thereof in the preparation of a drug for treating diseases selected from osteoarthritis, rheumatoid arthritis, and periodontitis. E[-(B)m-(A)n-D]x Formula (I)

This application provides a method for preparing pH-responsive polyamino acid drug-loaded nanoparticles based on sarcosine and their application. Sar-NNCA, L-lysine-NCA, and L-phenylalanine-NCA are dissolved in anhydrous DMF and polymerized under argon protection with a hexamethyldisilazine initiator to obtain a polyamino acid block copolymer Sar-NNCA. 80 -Lys(Cbz) n -Phe 10 The crude product was deprotected under HBr / acetic acid and loaded with DOX to obtain Sar. 80 -Lys n -Phe 10 -DOX. This application describes the preparation of a pH-responsive polymer nanoplatform, Sar, by encapsulating doxorubicin in polysarcosine-polylysine-polyphenylalanine nanoparticles via Schiff base bonds. 80 -Lys n -Phe 10 -DOX is used for tumor treatment. These polyamino acid nanoparticles are spherical with an average particle size of approximately 200 nanometers, exhibiting pH-responsive properties, excellent cellular uptake capacity, and anti-tumor effects. In vitro experiments show that Sar... 80 -Lys n -Phe 10 The carrier material exhibits excellent biocompatibility. The newly synthesized Sar... 80 -Lys n -Phe 10 -DOX nanomicelles show promise as a drug delivery system for cancer treatment.

The present application relates to the technical field of polymer chemistry, and particularly relates to a responsive dendritic polyamino acid modified polyurethane and a preparation method and application thereof.The responsive dendritic polyamino acid modified polyurethane has a structure shown in formula I.The responsive dendritic polyamino acid modified polyurethane provided by the present application can specifically expose positive dendritic polylysine in the unique acidic environment of tumor tissue, trigger immunogenic death of tumor cells, release tumor antigens, and comprehensively activate an anti-tumor immune response.Meanwhile, the positive dendritic polylysine causes an increase in reactive oxygen species (ROS) of tumor cells, oxidizes a diselenium bond in the polyurethane into selenic acid, reduces the expression of immune checkpoints of tumor cells, reverses the immunosuppressive microenvironment of tumor tissue, realizes synergistic treatment of immune activation and reversal of the tumor immunosuppressive microenvironment, and realizes a better tumor immunotherapy effect.

The main purpose of the present invention is to develop a DDS useful for treating metastatic cancer. A polyion complex according to an embodiment of the present invention comprises: a block copolymer having a hydrophilic polymer segment and a poly(amino acid) segment; and a nucleic acid, wherein the poly(amino acid) segment includes two or more cationic amino acid residues and two or more hydrophobic amino acid residues, the hydrophobic amino acid residues are arranged alternately and / or randomly, and the hydrophobic amino acid residues include hydrophobic amino acid residues having a side chain CLogP value of 3 or more. The polyion complex has an average particle diameter of 100 nm or more.

The invention discloses a single-chain peptide folded nano-enzyme as well as a preparation method and application thereof, and belongs to the field of medical medicine materials. The skeleton selected by the invention is single-chain polyamino acid, and the nanoparticles formed by crosslinking can simulate folding of protein in morphology and can be degraded in vivo. A high-molecular polymer methoxyl-polyethylene glycol-amino group is used as an initiator, a middle segment is polyamino acid with two carboxyl groups or polyamino acid with two amino groups, and carboxyl / amino groups are coordinated with transition metal to form a relatively stable hammer cuttage structure. Different enzyme activities can be simulated after different metals are used for crosslinking. Wherein the peroxidase-like and oxidase-like nanoparticles can generate oxidative stress, and the superoxide dismutase-like and catalase-like nanoparticles can remove active oxygen. And a hydrophilic side chain is selected at the tail segment to form the hydrophilic chain-sphere-chain nano enzyme. The single-chain peptide folded nano-enzyme prepared by the invention can be applied to multiple fields such as anti-tumor and anti-inflammatory activity research or preparation of related drugs according to different enzymatic activities.

The present invention relates to the field of polymer chemistry, and more particularly to poly (amino acid) copolymers and their use in drug delivery applications. In particular, the present invention relates to a linear copolymer comprising a poly sarcosine block pSar comprising 15 to 99 sarcosine constituent units and a poly (amino acid) block pAA comprising 8 to 120 amino acid constituent units.

The present invention provides a method for manufacturing a solar cell and a solar cell module, which can improve durability and conversion efficiency, as well as a solar cell and a solar cell module. [Solution] A method for manufacturing a solar cell (10) includes the steps of forming an electron transport layer (3) on a first electrode (2), forming a light absorption layer (4) of a perovskite compound on the electron transport layer (3), forming a hole transport layer (5) on the light absorption layer (4), and forming a second electrode (6) on the hole transport layer (5). The step of forming the hole transport layer (5) and / or the step of forming the electron transport layer (3) includes a buffer layer formation step of forming a buffer layer (31, 51) between the hole transport layer (5) and the light absorption layer (4) and / or between the electron transport layer (3) and the light absorption layer (4). The buffer layer formation step involves adding a solution containing a polyamino acid obtained by polymerizing amino acids having charged side chains with reactive functional groups.

The invention discloses a composite medicine coating for treating pulmonary arterial hypertension, and belongs to the technical field of medical instruments. The coating is composed of an inert protective layer and a composite drug coating, the inert protective layer is a polyamino acid polymer, responds to pH change and is rapidly disintegrated only in the pH environment of a target site, and the loss of the composite drug coating in the delivery process is reduced; the composite drug coating is a composite component containing two or more gene regulatory factors and / or drugs, achieves a synergistic effect through a signal path, cells and a gene level, more efficiently regulates pulmonary artery endothelial cell dysfunction and smooth muscle cell injury, and has precise targeting and irreplaceability.

The invention belongs to the technical field of cigarette filter stick materials, and provides a biomimetic mineralization-based cigarette filter stick and a preparation method thereof.The cigarette filter stick is of a porous hierarchical composite structure guided in an interwoven fiber net shape, and raw materials comprise polysaccharide or modified polysaccharide, a polymer and inorganic salt, an organic framework of an interlaced fiber net structure constructed by polysaccharide or modified polysaccharide and a polymer attracts inorganic salt to be distributed along the organic framework, in-situ mineralization of the inorganic salt is induced to form inorganic mineral particles, and a porous layer is formed. The polymer comprises one or more of a polyester polymer, a polyamino acid polymer, a water-soluble polymer and an inorganic polymer; the inorganic salt comprises one or more of calcium phosphate, calcium silicate, silicate, calcium carbonate, carbonate and phosphate. The preparation process is mild and environmentally friendly, the method is suitable for large-scale application, functionalization and harm reduction of the cigarette filter stick can be achieved, and the prepared cigarette filter stick has good formability and mechanical stability.

The present invention discloses a long-acting antioxidant intelligent targeted nano antifouling agent and a preparation method thereof, belonging to the field of marine biofouling protection. Through electrostatic interaction, a fouling-sensitive responsive polymer is self-assembled onto the surface of an inorganic nano-functional core. The fouling-sensitive responsive polymer is sodium polyacrylate and polyarginine, and the surface of the inorganic nano-functional core is metal oxide nanoparticles. Sodium polyacrylate and polyarginine are alternately self-assembled on the surface of the metal oxide nanoparticles. Each time sodium polyacrylate and polyamino acid are alternately self-assembled, a layer of fouling-sensitive responsive polymer is coated on the inorganic nano-functional core until a complete fouling-sensitive polymer shell is formed on the surface of the inorganic nano-functional core. The preparation process of the present invention is simple, fast, safe and non-toxic, meeting the development requirements of environmental friendliness; for biological fouling, the nano antifouling agent of the present invention has intelligent targeted release, with short-term recognition and long-acting bactericidal functions.

The present invention relates to lipo-polyamino acid conjugates of formula (I), as well as to acceptable salts, stereoisomers, and mixtures thereof. The present invention also relates to self-assembled particles comprising these lipo-polyamino acid conjugates and optionally an active agent, as well as to compositions comprising the lipo-polyamino acid conjugates or self-assembled particles comprising them. The present invention also relates to the use of the lipo-polyamino acid conjugates, self-assembled particles or compositions comprising them in medicine, cosmetics, and diagnostics, as well as the use of the lipo-polyamino acid conjugates of formula (I) as carriers.

The present invention provides a polyamino acid hydrogel and a preparation method thereof, as well as a hydrogel catheter and a preparation method thereof. The present invention prepares chiral lysine N-carboxyl anhydride and L-glutamic acid N-carboxyl anhydride respectively, and then uses them as raw materials, initiates with double-terminal amino polyethylene glycol NH2-PEG-NH2, and prepares double-terminal polylysine polymers shown in formula (I'-1) / formula (I'-2) and double-terminal polyglutamic acid polymers of formula (II'), respectively. Afterwards, double-terminal polylysine polymer solutions and double-terminal polyglutamic acid polymer solutions are prepared respectively, and the two solutions are mixed in a catheter consisting of an electrospinning membrane, and quickly gelled to form a hydrogel catheter. The above-mentioned hydrogel is filled inside, which has a supporting effect on the catheter, avoids the problem that the hollow catheter is easy to collapse, and at the same time simulates the natural nerve cell extracellular matrix by the hydrogel itself and its degradation products, thereby achieving a better peripheral nerve defect repair effect.