112 results about "Polyamino acid" patented technology

The invention belongs to the technical field related to tumors, and discloses a preparation method of self-developing embolism microspheres. Comprising the following steps: producing calcium alginate microspheres through cross-linking, obtaining polyelectrolyte hydrogel microspheres through electrostatic complexation, and obtaining the self-developing embolism microspheres through amino cross-linking. According to the invention, sodium alginate and polyamino acid are used as raw materials for preparation, so that the preservative is safe and non-toxic and has biodegradability, and the degradation product has no toxic or side effect on human body. The microspheres are prepared by adopting an electrostatic spraying method, organic solvents are not used, and the microspheres are green and environment-friendly and have no toxic residues.

The invention provides a high-temperature-resistant shale inhibitor as well as a preparation method and application thereof, and belongs to the technical field of petroleum drilling. Natural polymer polyamino acid and carbon-rich solid matter biochar are used as raw materials to prepare the shale inhibitor, the biochar has the advantages of being high in thermal stability, porous, rich in surface oxygen-containing functional groups and the like, the biochar is combined with polyamino acid, and by means of the chemical effect of the polyamino acid and the physical blocking effect of the biochar, the shale inhibitor is prepared. The shale inhibitor can inhibit shale hydration expansion at high temperature and has good hydration dispersibility, and the prepared shale inhibitor is green and environment-friendly and has excellent high temperature resistance.

Bioadhesive microparticle formulations and methods for preparation thereof are described. The microparticle formulation comprises cross linked poly-amino acid microparticles and may be delivered alone or may be used for delivery of an agent to a biological surface.

The invention discloses an environment-friendly degradable plastic packaging bag and a preparation method thereof, belongs to the technical field of packaging bag preparation, and is used for solving the technical problem that the degradation capability and the mechanical property of an environment-friendly packaging bag in the prior art need to be further improved. According to the invention, the prepared carbonic acid bridged compact polyester is used as a main body skeleton to provide strength and film-forming property, silica acetal hybrid polysaccharide is introduced to form a compact and complex diffusion path inside and reduce gas and moisture permeation, and then active side chain polyamino acid is added to adjust interfacial compatibility and enhance structural stability, so that the film-forming property is improved. Through reasonable combination of the three components, the environment-friendly packaging bag keeps high tensile strength and tearing strength, meanwhile, the barrier property is remarkably improved, and gradual complete degradation is achieved in compost and soil environments.

The present invention relates to sulfur-containing lipid-polyamino acid conjugates of formula (I) and acceptable salts, stereoisomers and mixtures thereof. The invention also relates to self-assembled particles comprising these lipid / polyamino acid conjugates and optionally an active agent, and to compositions comprising lipid-polyamino acid conjugates or self-assembled particles comprising them. The invention also relates to the use of lipid-polyamino acid conjugates, self-assembling particles or compositions comprising them in medicine, cosmetics and diagnostics, and the use of lipid-polyamino acid conjugates of formula (I) as carriers.

The invention discloses an oligomeric amino acid dendritic macromolecular material as well as a preparation method and application thereof, and relates to the technical field of nano materials. The general formula of the oligomeric amino acid dendritic macromolecular material is TPE-(PEG) n-(Lys) x-(Arg) y, wherein TPE is a hydrophobic core, has an aggregation-induced emission characteristic, and can enhance the self-assembly capability and the tracing function of the nano-carrier; pEG is a connecting arm, so that the water solubility and biocompatibility of the material can be improved; lys is a branch skeleton and is a main construction unit of a dendritic macromolecule; arg is a functional terminal, guanidyl of Arg has strong positive charges, electrostatic binding with negatively charged nucleic acid can be promoted, and meanwhile cellular uptake can be enhanced possibly through the membrane penetration effect. The oligomeric amino acid dendritic macromolecular material gives consideration to stability, modifiability and targeting, provides a new scheme for small nucleic acid delivery, and is expected to have far-reaching influence in the fields of precise tumor treatment, gene therapy and multi-modal diagnosis and treatment.

Disclosed is a selenium-containing polyamino acid having a structure represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein A, B, D, E, m, n, and x are as defined in the description. Also disclosed is a pharmaceutical composition containing the selenium-containing polyamino acid or a pharmaceutically acceptable salt thereof. Also disclosed is a use of the selenium-containing polyamino acid or the pharmaceutically acceptable salt thereof, or the pharmaceutical composition containing the selenium-containing polyamino acid or the pharmaceutically acceptable salt thereof in the preparation of a drug for treating diseases selected from osteoarthritis, rheumatoid arthritis, and periodontitis. E[-(B)m-(A)n-D]x Formula (I)

This application provides a method for preparing pH-responsive polyamino acid drug-loaded nanoparticles based on sarcosine and their application. Sar-NNCA, L-lysine-NCA, and L-phenylalanine-NCA are dissolved in anhydrous DMF and polymerized under argon protection with a hexamethyldisilazine initiator to obtain a polyamino acid block copolymer Sar-NNCA. 80 -Lys(Cbz) n -Phe 10 The crude product was deprotected under HBr / acetic acid and loaded with DOX to obtain Sar. 80 -Lys n -Phe 10 -DOX. This application describes the preparation of a pH-responsive polymer nanoplatform, Sar, by encapsulating doxorubicin in polysarcosine-polylysine-polyphenylalanine nanoparticles via Schiff base bonds. 80 -Lys n -Phe 10 -DOX is used for tumor treatment. These polyamino acid nanoparticles are spherical with an average particle size of approximately 200 nanometers, exhibiting pH-responsive properties, excellent cellular uptake capacity, and anti-tumor effects. In vitro experiments show that Sar... 80 -Lys n -Phe 10 The carrier material exhibits excellent biocompatibility. The newly synthesized Sar... 80 -Lys n -Phe 10 -DOX nanomicelles show promise as a drug delivery system for cancer treatment.

The present application relates to the technical field of polymer chemistry, and particularly relates to a responsive dendritic polyamino acid modified polyurethane and a preparation method and application thereof.The responsive dendritic polyamino acid modified polyurethane has a structure shown in formula I.The responsive dendritic polyamino acid modified polyurethane provided by the present application can specifically expose positive dendritic polylysine in the unique acidic environment of tumor tissue, trigger immunogenic death of tumor cells, release tumor antigens, and comprehensively activate an anti-tumor immune response.Meanwhile, the positive dendritic polylysine causes an increase in reactive oxygen species (ROS) of tumor cells, oxidizes a diselenium bond in the polyurethane into selenic acid, reduces the expression of immune checkpoints of tumor cells, reverses the immunosuppressive microenvironment of tumor tissue, realizes synergistic treatment of immune activation and reversal of the tumor immunosuppressive microenvironment, and realizes a better tumor immunotherapy effect.

The main purpose of the present invention is to develop a DDS useful for treating metastatic cancer. A polyion complex according to an embodiment of the present invention comprises: a block copolymer having a hydrophilic polymer segment and a poly(amino acid) segment; and a nucleic acid, wherein the poly(amino acid) segment includes two or more cationic amino acid residues and two or more hydrophobic amino acid residues, the hydrophobic amino acid residues are arranged alternately and / or randomly, and the hydrophobic amino acid residues include hydrophobic amino acid residues having a side chain CLogP value of 3 or more. The polyion complex has an average particle diameter of 100 nm or more.

The present invention provides a method for manufacturing a solar cell and a solar cell module, which can improve durability and conversion efficiency, as well as a solar cell and a solar cell module. [Solution] A method for manufacturing a solar cell (10) includes the steps of forming an electron transport layer (3) on a first electrode (2), forming a light absorption layer (4) of a perovskite compound on the electron transport layer (3), forming a hole transport layer (5) on the light absorption layer (4), and forming a second electrode (6) on the hole transport layer (5). The step of forming the hole transport layer (5) and / or the step of forming the electron transport layer (3) includes a buffer layer formation step of forming a buffer layer (31, 51) between the hole transport layer (5) and the light absorption layer (4) and / or between the electron transport layer (3) and the light absorption layer (4). The buffer layer formation step involves adding a solution containing a polyamino acid obtained by polymerizing amino acids having charged side chains with reactive functional groups.

The invention discloses a composite medicine coating for treating pulmonary arterial hypertension, and belongs to the technical field of medical instruments. The coating is composed of an inert protective layer and a composite drug coating, the inert protective layer is a polyamino acid polymer, responds to pH change and is rapidly disintegrated only in the pH environment of a target site, and the loss of the composite drug coating in the delivery process is reduced; the composite drug coating is a composite component containing two or more gene regulatory factors and / or drugs, achieves a synergistic effect through a signal path, cells and a gene level, more efficiently regulates pulmonary artery endothelial cell dysfunction and smooth muscle cell injury, and has precise targeting and irreplaceability.

The invention belongs to the technical field of cigarette filter stick materials, and provides a biomimetic mineralization-based cigarette filter stick and a preparation method thereof.The cigarette filter stick is of a porous hierarchical composite structure guided in an interwoven fiber net shape, and raw materials comprise polysaccharide or modified polysaccharide, a polymer and inorganic salt, an organic framework of an interlaced fiber net structure constructed by polysaccharide or modified polysaccharide and a polymer attracts inorganic salt to be distributed along the organic framework, in-situ mineralization of the inorganic salt is induced to form inorganic mineral particles, and a porous layer is formed. The polymer comprises one or more of a polyester polymer, a polyamino acid polymer, a water-soluble polymer and an inorganic polymer; the inorganic salt comprises one or more of calcium phosphate, calcium silicate, silicate, calcium carbonate, carbonate and phosphate. The preparation process is mild and environmentally friendly, the method is suitable for large-scale application, functionalization and harm reduction of the cigarette filter stick can be achieved, and the prepared cigarette filter stick has good formability and mechanical stability.

The invention relates to physically stable compositions in the form of an injectable aqueous solution, having a pH between 6.0 and 8.0, comprising at least: a) a basal insulin having an isoelectric point (pI) between 5.8 and 8.5 and b) a co-polyamino acid bearing carboxylate charges and at least one hydrophobic radical.

The invention discloses a cleaning care solution, the care solution comprises a functional component and an auxiliary component besides water, the mass ratio of the functional component to the auxiliary component is (1.0-3.0): (10-20), and the functional component comprises a polyamino acid polysaccharide condensate aqueous solution and folic acid. The cleaning care solution has the following functions: (1) the cleaning care solution is used for cleaning female vulva parts; (2) moisturizing the stratum corneum of the human body; (3) promoting proliferation of lactobacillus at the vulva part; and (4) inhibiting the growth of pathogenic bacteria and maintaining the micro-ecological balance of the vulva.

This invention provides a fiber spinning mother liquor containing Mg-MOF, comprising: 0.01-5 parts by weight of Mg-MOF; 0.1-15 parts by weight of polyamino acids; 5-15 parts by weight of polyvinyl alcohol; 0.5-1.5 parts by weight of crosslinking agent; 0.1-10 parts by weight of acidic mucopolysaccharide and / or monosaccharide; and water to a total of 100 parts by weight. Compared with the prior art, the fiber spinning mother liquor provided by this invention contains Mg-MOF. The polyphenols and polyamino acids in its components can play an anti-inflammatory and antibacterial role, while Mg ions have the effect of promoting skin repair. Furthermore, Mg-MOF has a positive charge and can interact with the negatively charged spinning mother liquor through electrostatic interaction, so that Mg-MOF is uniformly dispersed in the spinning solution, which is more conducive to spinning and forming. The prepared fiber membrane has broad application prospects in wound healing, antibacterial repair, etc., greatly improving the application value of the material.

The invention provides a PDRN-crosslinked sodium hyaluronate composition and application thereof. The PDRN-crosslinked sodium hyaluronate composition is prepared from the following components in parts by mass: 2 to 5 parts of PDRN, 2 to 15 parts of oxidized sodium hyaluronate, 4 to 20 parts of polyamino acid and 100 to 400 parts of deionized water. The PDRN-crosslinked sodium hyaluronate composition further comprises a protective agent, and the protective agent comprises at least one of trehalose and glycine; the PDRN-cross-linked sodium hyaluronate composition also comprises a small molecule hydroxyethylamine substance. According to the PDRN-cross-linked sodium hyaluronate composition, amido in polyamino acid and active carbonyl of oxidized sodium hyaluronate are subjected to in-situ gelation through a Schiff base reaction and are matched with PDRN to form PDRN-cross-linked sodium hyaluronate gel, and the gel has excellent binding stability, is not prone to degradation, convenient to store and simple to prepare, and can be used for preparing the PDRN-cross-linked sodium hyaluronate composition. No chemical cross-linking agent needs to be added, and the method is suitable for industrial production.

The invention discloses a compound preparation entrapped with a QC inhibitor as well as a preparation method and application of the compound preparation, and relates to the technical field of medicinal chemistry and biological materials. The composite preparation comprises a drug-loaded micelle and a hydrogel loaded with the drug-loaded micelle, the drug-loaded micelle comprises a QC inhibitor or a prodrug thereof, and a polyethylene glycol-polyamino acid block copolymer and a nonionic surfactant which entrap the QC inhibitor or the prodrug thereof, the structural formula of the QC inhibitor is shown in the specification. The hydrogel is prepared from chitosan, beta-sodium glycerophosphate and water. According to the compound preparation, a double sustained-release system of'hydrogel macroscopic sustained-release drug-loaded micelle and drug-loaded micelle microcosmic sustained-release drug 'is constructed, the release rate of a QC inhibitor is greatly delayed, the effective blood concentration can be maintained for several weeks, the administration interval is expected to be prolonged, and the compliance of a patient is remarkably improved.

The present application relates to the preparation method of carboxyl endocyclic anhydride and the preparation product. The preparation method of compound of formula (II) comprises the following steps: reacting compound of formula (I) with a cyclization reagent to generate compound of formula (II) and acid, and using an epoxide compound as an acid scavenger. The present application is a new synthesis method of carboxyl endocyclic anhydride, which has the advantages of low cost, low requirement for reagents, site and equipment, mild conditions, wide substrate application range, high functional group tolerance, recyclable solvent and other high value-added by-products in the synthesis route, less waste liquid discharge, easy scale-up, high industrial and academic value, and the like, and can greatly promote the rapid large-scale production and application of polyamino acid, polyhydroxy acid (polyester), polymercaptan acid (polythioester) and the like.

To provide a composition for delivering a nucleic acid capable of delivering the nucleic acid into a cell and obtaining the function of the nucleic acid.SOLUTION: The composition for delivering a nucleic acid comprises a fine particle containing a polyamino acid and a nucleic acid held by the fine particle.SELECTED DRAWING: Figure 1

The invention relates to the technical field of biological materials, in particular to an amphiphilic polyamino acid nano-vesicle and a preparation method and application thereof, and polyamino acid has a structure as shown in a formula I. The nano-vesicle is obtained by self-assembling polyamino acid with a specific block ratio in an organic solvent / water or water-containing solvent system. According to the invention, the nano-carrier with a nano-vesicle structure with a uniform particle size is prepared by adopting a nano-precipitation method. The nano-carrier has good chemical stability, biocompatibility, high loading capacity and uniform size and morphology, so that the problem that a traditional polyamino acid material is non-uniform and uncontrollable in morphology is solved, and the nano-carrier can be applied to the fields of drug delivery, tumor treatment and the like. Formula I

This invention discloses an essential oil nanoemulsion based on amphiphilic polyamino acids, its preparation method, and its applications, relating to the field of emulsion preparation technology. The preparation method of the essential oil nanoemulsion includes: grafting amino acids with hydrophobic residues onto polyaspartic acid to synthesize amphiphilic polyamino acids; mixing the amphiphilic polyamino acids with essential oils uniformly to obtain an essential oil nanoemulsion with good stability; this invention also provides applications of the essential oil nanoemulsion in food, cosmetics, or pharmaceutical preparations. This invention, by grafting amino acids with hydrophobic residues onto polyaspartic acid to form amphiphilic polyamino acids; using the amphiphilic polyamino acids as emulsifiers to emulsify essential oils, and preparing essential oil nanoemulsions through a spontaneous emulsification method, not only improves the water solubility and stability of essential oils but also reduces their volatility and irritating odor, while also possessing good biocompatibility and biodegradability, expanding the applications of essential oils in the food, daily chemical, and pharmaceutical fields.

The invention provides a preparation method of a dimer amino acid compound. The preparation method comprises the following steps: providing L-serine, an indole derivative, Tm9D8 * protein, PmLAAD protein and dimer synthetase, and culturing the L-serine, the indole derivative, the Tm9D8 * protein, the PmLAAD protein and the dimer synthetase; wherein the dimer synthetase comprises an amino acid sequence which is shown as any one of SEQ ID NO: 1-4 or has at least 90% of identity with the dimer synthetase. The invention also provides a cell division inhibitor containing the dimeric amino acid compound, and a composition containing the dimeric amino acid compound or the cell division inhibitor.

The invention relates to polyamino acid with a structural unit as shown in a formula 1, a preparation method of the polyamino acid and application of the polyamino acid as a hydrogel material or a temperature-sensitive material. According to the polyamino acid of the present invention, the secondary structure of the polyamino acid (e.g., polylysine) can be changed by linking a poly (ethylene glycol) (OEG) fragment to an epsilon-amino group of lysine using a urethane bond as a specific linking bond and specifically controlling the number m of OEG repeating units and the degree n of polymerization of the amino acid. The obtained polyamino acid can be used as an excellent hydrogel material or a temperature-sensitive material, and has a huge application prospect in biomedical application.

The present invention provides: a method for manufacturing a solar cell, with which it is possible to improve durability and conversion efficiency; a method for manufacturing a solar cell module; a solar cell; and a solar cell module.　A method for manufacturing a solar cell 10 includes: a step for forming an electron transport layer 3 on a first electrode 2; a step for forming a light absorption layer 4 of a perovskite compound on the electron transport layer 3; a step for forming a hole transport layer 5 on the light absorption layer 4; and a step for forming a second electrode 6 on the hole transport layer 5. The step for forming the hole transport layer 5 and / or the step for forming the electron transport layer 3 includes a buffer layer formation step for forming a buffer layer 31, 51 between the hole transport layer 5 and the light absorption layer 4 and / or between the electron transport layer 3 and the light absorption layer 4. In the buffer layer formation step, a solution which contains a polyamino acid that is obtained by polymerizing an amino acid having a charged side chain of a reactive functional group is added.

The invention relates to an amphiphilic polyamino acid assembly as well as a preparation method and application thereof, and belongs to the technical field of macromolecular biological materials. In order to solve the technical problems in the prior art that the preparation process of polyamino acid is limited and the polymerization-induced self-assembly reaction is difficult to carry out due to the characteristic that N-carboxylic anhydride is easy to hydrolyze, the invention provides the preparation method of the amphiphilic polyamino acid assembly. Controlling the pH value in the reaction system; and hydrophilic macromolecular amino-terminated polyethylene glycol monomethyl ether is selected as an initiator. The preparation method provided by the invention is simple and easy to operate, the preparation cost is relatively low, the product purity is relatively high, the synthesis efficiency is relatively high, the product property is stable, the product structure is simple and easy to regulate and control, and the product has certain stereoregularity and can be applied to industrial large-scale preparation of the polyamino acid assembly; and the material can be used as a drug release carrier to be applied to biomedical materials.

The invention relates to a high-absorptivity glycoside compound synergistic water-soluble fertilizer and a preparation method thereof. The water-soluble fertilizer comprises the following components in parts by weight: a nitrogen source, a phosphorus source, a potassium source, chelated trace elements, a water-soluble organic matter, an auxiliary agent, a structure stabilizer and an absorption promoting component, the absorption promoting component is composed of a cyclodextrin inclusion glycoside compound, sodium alginate oligosaccharide and sodium polyaspartate, and the structure stabilizer is chitosan quaternary ammonium salt. The glycoside compound is clathrated by cyclodextrin, so that the stability and the availability of the glycoside compound in a water-soluble system are improved, and the polysaccharide oligomer and the polyamino acid substance are combined to synergistically promote root system absorption and in-vivo transport. Through step-by-step preparation of the absorption promotion mother liquor and the nutritive salt mother liquor and compounding modulation, uniform dispersion of the components and stability of the system are realized. Test results show that the water-soluble fertilizer can improve the accumulation level of glycoside targets in plants and synchronously promote mineral nutrition absorption and yield and quality improvement, and is suitable for water-fertilizer integrated application of various crops.

The present invention relates to the technical field of hydrogels. Disclosed are a polyamino acid and a preparation method therefor, a hydrogel, and a chronic wound dressing. The polyamino acid has a structure represented by formula 1, wherein m, n, x, and y are the degree of polymerization, 30≤m≤60, 10≤n≤40, 1≤x≤100, 1≤y≤100, R1, R2, and R3 are independently selected from C1-C10 alkyl, and R4 is selected from OH, benzyloxy, amino, and C1-C4alkoxy. The polyamino acid is mixed with water to be converted into a temperature-sensitive hydrogel, the temperature-sensitive hydrogel is loaded with linagliptin and curcumin to obtain a drug-loaded temperature-sensitive hydrogel, and the drug-loaded temperature-sensitive hydrogel can be used as a chronic wound dressing for the treatment of a chronic wound and exhibits a good therapeutic effect. In addition, the drug-loaded temperature-sensitive hydrogel of the present invention exhibits few side effects on skin wounds because of the inclusion of fragments and has great application value.

Disclosed is a selenium-containing polyamino acid having a structure represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein A, B, D, E, m, n and x are as defined in the specification. Also disclosed is a pharmaceutical composition comprising a selenium-containing polyamino acid or a pharmaceutically acceptable salt thereof. Also disclosed is the use of the selenium-containing polyamino acid or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising the selenium-containing polyamino acid or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating diseases selected from osteoarthritis, rheumatoid arthritis and periodontitis. Formula (I): E [-(B) m-(A) n-D] x.