67 results about "Basic amino acids" patented technology

The present disclosure provides daptomycin formulations which have improved chemical stability, faster reconstitution times when reconstituted from the solid state and longer in-use stability. The compositions comprise daptomycin, one basic amino acid or its salt and optionally one or more pH adjusting agents.

The present application relates to: a culture medium composition for microorganisms of Corynebacterium species, in which part of ammonium sulfate is replaced with a different ammonium-containing compound; and a method for producing a basic amino acid by using the culture medium composition.

This invention discloses a method for preparing a Schiff base corrosion inhibitor for AZ91D magnesium alloy coolant. The method involves adding an ethanol or acetone solution of the ketone-containing heterocyclic compound dropwise to an aqueous solution of the alkaline amino acid at a molar ratio of 1:1 to 1.5. The reaction is carried out at 40–80°C for 4–36 hours, followed by concentration, extraction with glacial ethyl acetate, washing with glacial ethyl acetate, and drying to obtain the corrosion inhibitor. Further, the corrosion inhibitor is formulated into a coolant specifically for AZ91D magnesium alloy. This coolant is composed of a mixture of raw materials with the following weight percentages: 0.1–2% corrosion inhibitor, 39–60% deionized water, and 39–60% ethylene glycol. This invention features a simple preparation process, and the obtained corrosion inhibitor can be stored for a long time, exhibits good thermal stability, strong oxidation resistance, low conductivity, high corrosion inhibition efficiency, and good corrosion inhibition effect on AZ91D magnesium alloy.

The invention provides a copolymer polypeptide as well as a pharmaceutical composition and application thereof. The copolymer polypeptide is formed by linear random copolymerization of a first monomer, a second monomer and a third monomer; the first monomer is selected from any one of alkaline amino acid and derivatives thereof; the second monomer is selected from any one of acidic amino acid and derivatives thereof; the third monomer is selected from any one of neutral amino acid and derivatives thereof. The copolymer polypeptide and the pharmaceutical composition thereof provided by the invention can effectively relieve hyperkeratosis caused by psoriasis, relieve inflammatory enteritis and effectively inhibit tumor growth.

A method for producing an HSL protein with increased catalytic activity to oxidize a 4-HPPD inhibitor in a 2-oxoglutarate-dependent manner is disclosed. A method for producing a plant with increased resistance to a 4-HPPD inhibitor using the method for producing the HSL protein is also disclosed. It has been revealed that, by mutating position 140 to a basic amino acid in an HSL protein, the catalytic activity of the protein to oxidize a 4-HPPD inhibitor in a 2-oxoglutarate-dependent manner can be increased, and an activity of the protein to decompose the inhibitor can be increased.

A composition for treating dentin hypersensitivity, comprising: a first component comprising: (i) a first rheology modifying polymer; (ii) a calcium ion source; (iii) a positively charged basic amino acid; and (iv) an acidifying agent, wherein the first component has a pH in the range of about 2.0 to about 7.0; a second component comprising: (i) a second rheology modifying polymer; (ii) a phosphate ion source; and (iii) an alkalizing agent, wherein the second component has a pH in the range of about 7.0 to about 14.0; wherein the first component and the second component are combined into a mixture such that a cationic amorphous calcium phosphate gel composition is created instantly when the pH of the mixture reaches a pH range of about 7.0 to about 9.5.

The application relates to the technical field of biological pharmacy, in particular to an antibacterial peptide AI-SC-4 and application thereof. The antibacterial peptide AI-SC-4 is an artificial synthetic non-natural 22-peptide, the amino acid sequence is shown in SEQ ID NO:1, the theoretical molecular weight is 2700.26 Da, and the antibacterial peptide is a cationic amphiphilic polypeptide rich in basic amino acids and hydrophobic amino acids. The antibacterial peptide has the advantages of clear structure, small molecular weight and convenient artificial synthesis, and shows strong in-vitro antibacterial activity on gram-positive bacteria and gram-negative bacteria, and can be used for drug for resisting drug-resistant bacteria infection, a disinfectant, a skin external preparation and an oral care product, and has a wide application prospect.

The application belongs to the technical field of medical preparations, and particularly relates to a high-dissolution solid preparation of multitarget and a preparation method thereof. The solid preparation is composed of 5-20% of multitarget, 10-30% of alkaline amino acid, 40-70% of hydrophilic filler, 2-10% of disintegrant, 0.1-1% of metal ion complexing agent and 0.5-2% of lubricant according to percentage by weight. The multitarget and the alkaline amino acid form a co-amorphous state in a molar ratio of 1:1 to 1:3. The preparation method comprises the following steps: dissolving the multitarget and the alkaline amino acid in an organic solvent containing volatile acid, removing the solvent under reduced pressure to obtain a co-amorphous substance, mixing the co-amorphous substance with the hydrophilic filler, the disintegrant and the metal ion complexing agent, and mixing the mixture with the lubricant after dry granulation and then compressing the mixture into tablets. The application eliminates the lattice energy limitation of the multitarget, realizes supersaturated dissolution, inhibits recrystallization during storage, maintains stable dissolution curve, improves drug loading capacity, and avoids damage to the amorphous state caused by moisture and heat through dry granulation.

The invention claimed herein relates to a dielectric polishing composition and a method thereof. The invention claimed herein particularly relates to a composition comprising: (A) surface-modified colloidal silica particles comprising negatively charged groups on the surface of the particles, wherein the surface-modified colloidal silica particles have a negative charge, a particle size of 60 nm to 200 nm, and a zeta potential of < -35 mV at a pH in the range of > 2.0 to < 6.0; (B) at least one corrosion inhibitor selected from at least one guanidine derivative; (C) at least one iron (III) oxidizing agent; (D) at least one buffering agent selected from at least one basic amino acid having an isoelectric point (pi) of > 6.5; (E) at least one stabilizer; and (F) an aqueous medium, wherein the pH of the composition is in the range of > 2.0 to < 4.3, and wherein the composition has a polyacrylamide content of < 1 ppm.

Use of compositions comprising N-long-chain acyl amino acids and / or their salts to prevent hair loss and / or promote hair growth and / or increase hair density, particularly relating to related compositions comprising N-long-chain acyl amino acids and basic amino acids.

The application discloses a fluorescent probe for simultaneously detecting chiral acidic amino acids and basic amino acids, a preparation method, a detection method and a paper-based sensor thereof, and a specific chemical structural formula of the fluorescent probe is shown in the following formula: the fluorescent probe is simple in preparation and low in cost, and is high in detection sensitivity and good in selectivity for the acidic amino acids and the basic amino acids.

This application discloses an HIV antigen comprising the gp41 protein; said gp41 protein contains at least one amino acid residue selected from the following: T at position 85; K at position 98; a basic amino acid R or K at position 109; a neutral amino acid L or I at position 111; a basic amino acid K or R at position 132; N at position 133; and an acidic amino acid D or E at position 139. The HIV antigen of this application has the advantages of high specificity and high sensitivity.

The application belongs to the technical field of 5-methyl-3-en-2-hexanone preparation, and discloses a zeolite-supported basic amino acid catalyst and its application in the preparation of 5-methyl-3-en-2-hexanone. The zeolite-supported basic amino acid catalyst is made of a zeolite molecular sieve and a basic amino acid supported on the zeolite molecular sieve, and the loading amount of the basic amino acid is 10-50 wt% based on the total mass of the catalyst; the zeolite molecular sieve includes an alkali-treated ZSM-5, SBA-15 or Beta zeolite molecular sieve, and the basic amino acid includes one or both of arginine and lysine. The high-stability aldehyde-ketone condensation active site catalyst is formed by strong interaction between the basic amino acid and the surface hydroxyl groups of the molecular sieve, and is applied to the preparation of 5-methyl-3-en-2-hexanone through aldehyde-ketone condensation dehydration, so that the catalytic activity of the amino acid can be fully utilized, the selectivity of the product can be improved, the recovery rate of the catalyst can be improved, and the use amount of the amino acid can be reduced.

The purpose of the present invention is to provide a composition or the like capable of enhancing the flavor of a food at a specific product temperature.　The present invention relates to a composition or the like for enhancing the flavor of a food at a product temperature of -20 to 10°C, the food containing 1.5 wt% or more in total of at least one carbohydrate compound selected from the group consisting of fructose, maltose, glucose, lactose, and sugar alcohol, wherein the composition contains (A) a γ-glutamyl peptide or a salt thereof, (B) tartaric acid or a salt thereof, and (C) at least one selected from the group consisting of a basic amino acid or a salt thereof.

To provide a human anti-TSLP antibody preparation and a method for treating inflammatory diseases. [Solution] This specification provides an aqueous composition comprising (a) an anti-TSLP antibody at a concentration greater than about 140 mg / mL, (b) a surfactant, and (c) at least one basic amino acid or a salt thereof. Also provided is an aqueous composition comprising (a) an anti-TSLP antibody at a concentration greater than about 140 mg / mL, (b) a surfactant, and (c) at least one calcium or magnesium salt. Related manufacturing articles, pre-filled syringes, and vials containing the compositions of this disclosure are also provided. This specification provides the use of the compositions for treating inflammatory diseases, such as atopic dermatitis. This specification also provides a method for producing a stable liquid antibody having a viscosity of less than about 100 cP.

The application belongs to the technical field of new small-molecule drugs, and particularly relates to a zwitterionic fluorescent probe containing a dimeric targeting ligand as well as a preparation method and application thereof.The chemical structural formula of the zwitterionic fluorescent probe containing the dimeric targeting ligand is shown as formula (1): The fluorescent probe can be used for near-infrared fluorescence imaging of tumor targeting, and the two identical tumor targeting ligands contained in the structure have better targeting function compared to a single targeting ligand.The introduction of basic amino acids in the fluorescent probe makes the charge on the surface of the probe zero, and the zwitterionic design makes the probe have a lower tissue background signal.The probe structure is completely symmetrical, the synthesis method is simpler, the water solubility is good, the non-specific fluorescence signal is low, and the probe is suitable for industrialized production and clinical application.

The application discloses a preparation method of high-solubility chickpea protein dispersion, and belongs to the technical field of food protein deep processing. The method comprises the following steps: (1) dispersing chickpea protein powder in deionized water, adjusting the pH to neutral, fully stirring, and standing overnight; (2) performing water bath heating, high-pressure homogenization and alkaline amino acid combined treatment on the chickpea protein dispersion obtained in the step (1), uniformly stirring, and obtaining modified chickpea protein dispersion; and (3) standing the chickpea protein dispersion obtained in the step (2) overnight, so that the high-solubility chickpea protein dispersion is obtained. The method provided by the application can make the solubility of the chickpea protein dispersion reach more than 85%, has the advantages of greenness, safety, high efficiency, continuous large-scale processing and production and the like compared with the prior art, and further expands the application value of the chickpea protein in the development of plant protein beverages and functional foods.

The invention relates to a method for producing a trypsin-like protease in Bacillus, the method comprising expressing in a Bacillus host cell a gene coding for a preproenzyme comprising or consisting of (i) a trypsin-like protease having a sequence identity of at least 70% compared to the wild-type trypsin-like protease from the fungus Fusarium oxysporum, and (ii) a prosequence located upstream of the trypsin-like protease and having at its C-terminus a basic amino acid residue, and (iii) a bacterial secretion signal sequence located upstream of the trypsin-like protease and of the optionally present prosequence, wherein the bacterial secretion signal sequence is capable of directing secretion in a Bacillus host cell to a culture medium, thereby providing a culture medium comprising the mature trypsin-like protease.

The invention relates to the field of food science and engineering, and discloses a sodium-reduced preserved goose pickling liquid based on basic amino acid, a preparation method and application, the sodium-reduced preserved goose pickling liquid comprises deionized water, sodium chloride, potassium chloride and basic amino acid, and the basic amino acid is preferably a combination of L-lysine, L-arginine and L-histidine; the preparation and the application relate to a step-by-step dissolving and compounding process, a static low-temperature pickling process, a ventilation air drying process and a low-temperature curing process. Alkaline amino acid is introduced into a sodium-reduced and potassium salt substitution system, swelling of myofibrillar protein is promoted through side chain cationic groups of the basic amino acid, and oxidation reaction is blocked in combination with metal chelation and electron donor characteristics of the basic amino acid; the effects of reducing the sodium content, improving the gel network structure, inhibiting lipid oxidative rancidity and masking the bitter taste of potassium chloride are achieved, the problems of texture looseness and flavor deterioration caused by ion strength reduction of the low-salt meat product are solved, and the sensory quality and storage stability of the product are improved.

The invention discloses preparation and application of a proteoglycan colloid material capable of rapidly stopping bleeding and promoting wound healing, and belongs to the field of biological materials. Basic amino acid rich in lysine or arginine is designed and expressed through molecular engineering, and then basic protein and hyaluronic acid with negative electricity are combined through a supramolecular assembly method to prepare a proteoglycan material with antibacterial ability. Then, recombinant mucoprotein rich in tyrosine is designed and expressed, and a DOPA adhesion group is formed through tyrosinase modification, so that the instant adhesion of the tissue adhesion material is enhanced. The amino acid of the basic protein remarkably enhances the interaction of various molecules of proteoglycan, meanwhile, the basic amino acid endows the tissue adhesive with excellent antibacterial ability, and the tissue adhesive provided by the invention has instant tissue adhesion performance, excellent biocompatibility and excellent antibacterial ability and hemostatic performance, and is suitable for being used in the field of medical instruments. The healing of different types of bleeding scenes and irregular wounds is facilitated.

A peptide may include a sequence having 80% or more amino acid identity with the amino acid sequence of SEQ ID NO. 1, i.e., RPSX1CNLPVKPGPCX2GFFSAFYYSQKX3NKCHSFTYGGCAGNANRFSTX4EKCRRTC X5X6, wherein, X1 is the amino acid residue F or G, X2 is any amino acid residue, except a basic amino acid residue, X3 is the amino acid residue T or D, X4 is the amino acid residue I, L, or E, (i) X5 is V and X6 is G or (ii) X5 is G and X6 is V, and the amino acid located at position 39 is A. Such peptides may have various diagnostic and therapeutic uses.

This application belongs to the field of biomedical technology, specifically relating to hyaluronic acid nanospheres, their preparation methods, and applications. This application provides a method for preparing hyaluronic acid nanospheres, which involves the interaction of nucleic acids with hyaluronic acid salts in a specific ratio. The preparation process is optimized, resulting in hyaluronic acid nanospheres with high hyaluronic acid content, strong skin permeability, and good stability, meeting the application requirements for transdermal drug delivery and skincare products. Furthermore, this application uses a non-covalent bonding method to prepare the nanospheres, simplifying the preparation process, effectively improving the gelling properties of hyaluronic acid salts, reducing stickiness at high concentrations, and broadening the application scenarios of hyaluronic acid in skincare products.

The invention relates to the technical field of food freezing, in particular to a food antifreeze agent and a preparation method and application thereof. The food antifreeze agent comprises carboxymethyl chitosan (CMCh) and basic amino acid. The food antifreeze agent is a binary compound system designed according to the'head and tail 'structural characteristics of myosin, a complementary synergistic mechanism of'head targeting enhancement + tail precise regulation' is formed, the food antifreeze agent has a very good antifreeze effect, and effective antifreeze can be achieved by only 0.5% (by weight) of the antifreeze agent.

The invention relates to the technical field of polypeptide preparation, and discloses a spleen extract preparation method, which comprises: carrying out pretreatment, homogenization, freeze thawing crushing, precipitation separation and ultrafiltration on a mammal spleen tissue to obtain a spleen polypeptide extract; coupling the spleen polypeptide extract with ADC through a chemical coupling bridge to form a targeting compound; preparing an antioxidant-basic amino acid compound; mixing the coupling compound with a wall material solution containing a functional filling agent and an antioxidant-alkaline amino acid compound, and carrying out microencapsulation embedding; carrying out freeze drying on the microcapsules; and spraying a chitosan-sodium carboxymethyl cellulose polyelectrolyte compound on the surface of the freeze-dried microcapsule to carry out hydrophilic modification. The antioxidant-basic amino acid compound is used for blocking intermolecular chemical crosslinking, the cyclodextrin inclusion effect is used for preventing aggregation, and the polysaccharide composite hydrophilic layer is used for providing environmental tolerance, so that the chemical crosslinking rate of the product is reduced by 80% or above, and the aggregation rate is reduced to 5% or below.

The invention relates to the technical field of biological medicine chemical separation, and discloses a separation and purification process of high-purity ursodesoxycholic acid mother liquor, which comprises the following steps: adding alkaline amino acid into the mother liquor containing ursodesoxycholic acid, stirring and dissolving to obtain a water phase system; adding a neutral chiral hydrophobic deep-eutectic solvent formed by complexing L-menthol and long-chain fatty alcohol into the water-phase system, and carrying out mixed extraction; standing for layering, separating to remove an upper-layer oil phase, and collecting a lower-layer water phase; finally, acid is added into the water phase to adjust the pH value, and an ursodesoxycholic acid product is obtained through ultrasonic-assisted crystallization, cleaning and drying. According to the method disclosed by the invention, efficient separation of a target product from chenodeoxycholic acid and lithocholic acid is realized by utilizing the specific hydrophilic anchoring effect of the basic amino acid on ursodeoxycholic acid and cooperating with the chiral hydrophobic recognition effect of the eutectic solvent on impurities. The process is green and environment-friendly, the solvent can be recycled, and the obtained product is high in purity and suitable for industrial application.

The present application relates to tobacco flavor type regulation composition, tobacco flavor type regulator, tobacco processing method, and belongs to the technical field of tobacco processing.The tobacco flavor type regulation composition of the present application is composed of type I amino acid (aspartic acid and / or asparagine), sweet amino acid, umami amino acid, aromatic amino acid, sulfur-containing amino acid, basic amino acid and type II amino acid (isoleucine, valine, tryptophan), and when the tobacco flavor type regulation composition of the present application is used for processing tobacco, the tobacco flavor type can be highlighted, the migration can be realized, and the quality of the tobacco can be improved.

The presently claimed and described technology provides chromatography processes for purifying plasmid DNA (pDNA) using elution buffers containing at least one basic amino acid and / or at least one denaturant.

The invention discloses a modified chitosan-hydroxyapatite composite material as well as a preparation method and application thereof, and relates to the technical field of dental materials. The problems that an existing oral care product and a chitosan-hydroxyapatite composite material are narrow in antibacterial spectrum, not lasting in dentin desensitization effect, low in remineralization efficiency, poor in stability and difficult to give consideration to biological safety are solved. The preparation method of the modified chitosan-hydroxyapatite composite material comprises the following steps: dropwise adding an acetic acid aqueous solution of chitosan into an aqueous solution containing alkaline amino acid and a carboxyl activator, and carrying out mixed reaction, dialysis, filtration and freeze drying to obtain alkaline amino acid modified chitosan; dropwise adding a hydroxyapatite aqueous solution into the alkaline amino acid modified chitosan aqueous solution to carry out self-assembly reaction, centrifuging, taking supernate, filtering, and freeze-drying to obtain the modified chitosan-hydroxyapatite composite material. The prepared modified chitosan-hydroxyapatite composite material can be applied to the fields of oral care materials and nano sustained-release drug carriers.

This invention provides a pentapeptide-derived peptide YS for anti-skin aging and its applications, relating to the field of biochemistry. The pentapeptide-derived peptide YS comprises KTTKS and an N-terminal modified peptide. The N-terminal modified peptide consists of basic amino acids and uncharged amino acids arranged alternately, with the number of basic amino acids not less than 50%. The uncharged amino acids are selected from neutral amino acids and / or polar neutral amino acids. The number of uncharged amino acids arranged consecutively does not exceed three. The N-terminal amino acid of the N-terminal modified peptide is tyrosine, and the C-terminus consists of three consecutive uncharged amino acids. This invention modifies the N-terminus of the pentapeptide KTTKS with a specific structure of amphiphilic peptide, unexpectedly obtaining a pentapeptide-derived peptide YS with good water solubility and strong skin penetration, exhibiting significant anti-skin aging effects without the need for additional chemical penetration enhancers, making it safer and more effective.

The application relates to a chiral hydrogel wound dressing for monitoring a wound microenvironment, a preparation method and application, and belongs to the field of biological materials. The preparation method of the hydrogel wound dressing comprises the following steps: A, adding an L-basic amino acid derivative into a polymer solution to be dissolved to form a mixed solution; B, heating the mixed solution, pouring the mixed solution into a mold after the mixed solution is clarified and standing for cooling, performing first cross-linking, and forming a pre-gel in the mold; C, immersing the formed pre-gel in a salt solution to perform second cross-linking, and obtaining the hydrogel wound dressing for monitoring a wound microenvironment after the cross-linking product is washed. The hydrogel wound dressing for monitoring a wound microenvironment has good biocompatibility, can effectively promote wound healing, and can monitor the pH value of a microenvironment near a wound in real time and indicate the healing condition of the wound.