279 results about "Basic amino acids" patented technology

A cleaning composition, related cleaning products, and a use of the composition in reduction of skin or eye irritation, oil control, deodorization and other aspects. The present invention takes N-long-chain acyl amino acid and alkaline amino acid / inorganic base as main surfactants without containing a thickening agent, ethoxylate, a fatty acid salt, and a moisturizer, is mild and non-irritating, and can be used for bath cream, shampoo, facial cleansing mousse, a makeup remover, an oral cavity washing product, a shaving product, a hand sanitizer, a cleaning lotion or a multifunctional cleaning product.

The invention belongs to the technical field of indoor air pollution treatment, and particularly discloses an aluminum hydroxide loaded carbon quantum dot material for removing formaldehyde, gel and a preparation method of the aluminum hydroxide loaded carbon quantum dot material for removing formaldehyde, and the preparation method of the aluminum hydroxide loaded carbon quantum dot material comprises the following steps: uniformly mixing, grinding and dispersing amorphous aluminum hydroxide powder and basic amino acid; transferring into a microwave oven for microwave radiation reaction, filtering, washing and drying after the reaction is finished, and then crushing to obtain the aluminum hydroxide loaded carbon quantum dot material. The preparation method is simple in preparation process, short in reaction time and suitable for industrial production, and the prepared aluminum hydroxide loaded carbon quantum dot material and gel are high in formaldehyde removal rate and have long-term effectiveness.

The present disclosure is a polyethylene glycol modified zwitterionic fluorescent probe. The core luminescent group of the fluorescent probe of the present disclosure is a heptamethine chain which is connected by a phenoxy bridge and has a rigid ring structure in the center. The two ends of the heptamethine chain are two sulfonic indole groups, and two polyethylene glycol chains are connected with the indole groups. A tumor targeting ligand is connected with a luminescent group through one polyethylene glycol chain and one alkaline amino acid spacer. The probe of the present disclosure can be connected with polypeptides, small molecules and antibodies having a tumor targeting function, thereby achieving near-infrared fluorescence imaging for tumor targeting. The probe of the present disclosure has good druggability, and is extremely suitable for industrial production and clinical promotion.

The invention discloses a composition for cleaning or refreshing hair or scalp and application thereof, the composition takes N-long-chain acyl amino acid and basic amino acid as main surfactants, can not contain a thickening agent, ethoxylate, fatty acid salt and a humectant, has the properties of low irritation, selective cleaning, easiness in washing, no stickiness and the like, and can be used for cleaning or refreshing hair or scalp. The shampoo is especially suitable for no-wash or dry-wash shampoo products.

The invention discloses a reagent for detecting the activity of isocitrate dehydrogenase. The reagent consists of a first reagent and a second reagent, the first reagent comprises an electron carrier, isocitric acid or isocitrate, divalent metal ions, a first reagent buffer solution, a first reagent additive, a first reagent preservative and a first reagent surfactant; the divalent metal ions comprise metal ions; the second reagent comprises a dye which comprises tetrazolium salt and has an oxidation state and a reduction state, a cofactor, a second reagent buffer solution, a second reagent additive, a coenzyme stabilizer, a second reagent surfactant and a second reagent preservative; the pH is buffered to 7-9.5 and 5-9 by the first buffer solution and the second buffer solution respectively; the first reagent additive and the second reagent additive comprise divalent metal salt, sugar, sugar alcohol, protein, chelating agent and basic amino acid; the first and second reagent surfactants comprise nonionic and anionic surfactants; the first reagent preservative and the second reagent preservative comprise sodium azide or isothiazolinones. The invention further discloses a corresponding detection method.

The invention discloses basic amino acid modified 3S-PCL as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The basic amino acid modified 3S-PCL has a structural formula shown in the specification, wherein R is alkaline amino acid; m, m1 and m2 are all positive integers, and m, m1 and m2 are greater than or equal to 1. According to the invention, a basic amino acid modified three-arm polycaprolactone (3S-PCL) material is designed and synthesized, and the basic amino acid modified three-arm polycaprolactone (3S-PCL) material has good biocompatibility and can be used for lipid nanoparticle nucleic acid delivery instead of a cationic liposome. The preparation method of the basic amino acid modified 3S-PCL material is simple and rapid, and is especially suitable for industrial production. The lipid nanoparticles prepared by using the basic amino acid modified 3S-PCL material as a gene vector can realize efficient delivery of nucleic acid drugs.

The present disclosure provides daptomycin formulations which have improved chemical stability, faster reconstitution times when reconstituted from the solid state and longer in-use stability. The compositions comprise daptomycin, one basic amino acid or its salt and optionally one or more pH adjusting agents.

The invention discloses a cleaning composition, a related cleaning product and application of the composition in the aspects of reducing skin irritation or eye irritation, controlling oil, removing odor and the like, N-long-chain acyl amino acid and basic amino acid / inorganic base are used as main surface active agents, a thickening agent, ethoxylate, fatty acid salt and a humectant can be not contained, and the cleaning composition is mild and free of irritation; the compound can be used for shower gel, shampoo, cleansing mousse, cleansing products, oral washing products, shaving products, hand sanitizer, cleaning lotion or multifunctional cleaning products.

The invention provides a preparation method of high-gel-quality low-salt minced shrimp gel, which comprises the following steps: S1, chopping and mixing shrimp meat to obtain minced shrimp meat; s2, adding salt into the minced shrimp meat, and chopping to obtain minced shrimp; s3, adding alkaline amino acid into the minced shrimps, and chopping to obtain amino acid-minced shrimps; and S4, heating and cooling the amino acid-minced shrimps to obtain the high-gel-quality low-salt minced shrimp gel. According to the preparation method disclosed by the invention, the texture property, texture and taste of the low-salt minced shrimp gel are improved, so that the indexes such as the texture property and the water-holding capacity of the low-salt minced shrimp gel all have ideal effects; the preparation method is simple, green, safe, easy to implement and suitable for industrial production; the prepared low-salt minced shrimp gel with high gel quality overcomes a series of problems of low shrimp meat content, high salt content, unsatisfactory texture characteristics, low moisture retention capacity, weak gel strength and loose structure of the existing minced shrimp products.

The invention discloses a no-clean or dry-cleaning cleaning solution and application thereof, the cleaning solution takes N-long-chain acyl amino acid and alkaline amino acid as main surfactants, can not contain a thickening agent, ethoxylate, fatty acid salt and a humectant, and has the properties of low irritation, selective cleaning, no stickiness, no dry and tight skin after cleaning and the like.

The invention discloses a composition containing lauroyl alanine as well as a preparation method and application of the composition. The composition is prepared from the following components in parts by weight: 0.5 to 10 parts of lauroyl alanine, 0.5 to 5 parts of sodium cocoyl methyl taurate, 0.01 to 0.5 part of hydroxyethyl chitosan, 0.5 to 5 parts of basic amino acid and 1 to 20 parts of rice washing water. Through cooperation of the lauroyl alanine, the sodium cocoyl methyl taurate, the hydroxyethyl chitosan, the alkaline amino acid, the rice washing water and other components, the composition has the advantages of being rich and fine in foam, mild, small in irritation, capable of entering eyes, high in cleaning capacity, capable of being flushed with water, free of false smoothness, free of residues, not tight, capable of preserving moisture, environmentally friendly, degradable and the like.

The present invention discloses an encapsulated supramolecular oil control and antibacterial composition, a preparation method and its application. The encapsulated supramolecular oil control and antibacterial composition is composed of an organic acid, a basic amino acid and a cyclodextrin, wherein the organic acid is selected from one or more of salicylic acid, capryloyl glycine, azelaic acid and succinic acid, wherein the organic acid and the basic amino acid are connected by hydrogen bonds to form a supramolecular organic acid, and the composition contains a cyclodextrin inclusion complex formed by encapsulating the organic acid supramolecular. The oil control and antibacterial composition of the present invention encapsulates the organic acid supramolecular by cyclodextrin molecules, has good water solubility, low irritation, easy compatibility, high bioavailability, and the active components are not easy to precipitate. The combination of organic acids can also produce a synergistic effect, and the oil control and antibacterial effect is better.

To provide a topical composition with excellent adhesiveness to the skin.SOLUTION: A topical composition according to the present invention comprises (A) at least one polyhydric alcohol having a molecular weight of 100 to 200, and (B) at least one non-polymerizable cationic compound. The component (B) may be a compound containing a metal to be a divalent or higher cation in an aqueous solution, a basic amino acid, alkanol amine, or alkyl amine, and the component (A) may be glucose, sorbitol, fructose, xylitol, or erythritol.SELECTED DRAWING: None

The invention discloses an aspergillus oryzae engineering bacterium as well as a construction method and application of the aspergillus oryzae engineering bacterium, and relates to the technical field of genetic engineering. The method comprises the following steps of: (a) connecting and fusing an open reading frame of an endogenous gene with a fungal laccase copper oxidoreductase structural domain and a target heterologous protein gene through a dual-basic amino acid endopeptidase cleavage site gene; or connecting and fusing an open reading frame of an endogenous gene with a multi-copper oxidase structural domain and a target heterologous protein gene through a dual-basic amino acid endopeptidase cleavage site gene; and (b) at least one of a gene Aovps10, a gene AosedD and a gene Aoemp47 is knocked out. The aspergillus oryzae engineering bacterium provided by the invention can realize high-efficiency expression of the heterologous protein, and the extracellular yield of the heterologous protein is obviously improved.

The invention discloses a multifunctional cleaning solution, which takes N-long-chain acyl amino acid and basic amino acid as main surfactants, can not contain a thickening agent, ethoxylate, fatty acid salt and a humectant, and has the properties of low irritation, selective cleaning, no stickiness, no dry and tight skin after washing and the like.

Provided is a nanovaccine. The nanovaccine is prepared from the following starting materials: a sustained-release carrier, an antigen, an adjuvant, and a cationic component. The mass ratio of the sustained-release carrier to the antigen to the adjuvant to the cationic component is (1-30):1:(0.1-1):(0.05-0.5). The sustained-release carrier comprises sodium alginate. The antigen comprises at least one of a protein, a recombinant subunit, and a polypeptide. The cationic component comprises at least one of a calcium ion, a manganese ion, an aluminum ion, a polyamine, a basic amino acid, and a polyamino acid consisting of 2-30 basic amino acids. The nanovaccine comprises the sustained-release carrier sodium alginate, the antigen, the adjuvant, and the cationic component in a proper ratio. Sodium alginate is used as a sustained-release carrier and is promoted to form a network structure under the action of the cationic component, so as to encapsulate the antigen and the adjuvant, thereby forming a stable antigen-carrier-adjuvant nanoparticle gel. The nanovaccine can induce a stronger immune response and has good stability and good biocompatibility.

The present invention discloses a cyclic lipopeptide carrier for encapsulating nucleic acid drugs, comprising a cyclic lactone structure formed by a heptapeptide R1R2R2R3R1R2R2 and a β-hydroxy fatty acid with a carbon chain length of 6 to 44, and its general structural formula is as follows: #imgabs0# wherein R1 is a basic amino acid, including one of histidine His, lysine Lys or arginine Arg, R2 is one of the hydrophobic amino acids leucine Leu, isoleucine Ile or valine Val, and R3 is one of any amino acid; n is an integer of 2 to 40; the positively charged basic amino acids in the cyclic lipopeptide bind to the negatively charged nucleic acid drug through electrostatic interaction to form cyclic lipopeptide-nucleic acid particles. The cyclic lipopeptide carrier for encapsulating nucleic acid drugs provided by the present invention has high safety, can effectively protect nucleic acid drugs, improves their stability, and has good transfection efficiency for a variety of cells, and has broad application prospects in the field of nucleic acid drug delivery.

The invention relates to the field of gene engineering, in particular to a proximity marker enzyme mutant and application thereof. The proximity marker enzyme mutant takes ProtA-Turbo as a starting sequence, and one or more sites in K71, K240, K335, K345 and K351 are mutated into non-polar hydrophobic amino acid, polar neutral amino acid, acidic amino acid, basic amino acid or non-natural amino acid. The proximity marker enzyme mutant overcomes the influence of self biotinylation on the proximity marker activity, can continuously and stably mark the proximity proteome of the target protein on the immobilized cell, and obviously improves the sensitivity of identifying the proximity interacting protein of the target protein.

Compounds and methods are provided for inhibiting a PI4-kinase. Methods of treating a pathogen infection and methods of treating cancer are also provided. The PI4-kinase inhibitor can be a compound that is a 5-aryl or heteroaryl-thiazole, e.g., as described herein. In certain embodiments, the PI4-kinase inhibitor is a substituted 2-amino-5-phenylthiazole or substituted 2-amino-5-pyridylthiazole compound. In some embodiments, the compounds have broad spectrum anti-infective activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of treating a subject for cancer using a PI4-kinase inhibitor. Aspects of the methods include inhibiting PI4-kinase in a cancer cell to reduce cellular proliferation.

The invention belongs to the technical field of biological medicine, and particularly relates to hyaluronic acid nano-microspheres as well as a preparation method and application thereof. According to the preparation method of the hyaluronic acid nano-microspheres, the hyaluronic acid nano-microspheres are prepared through interaction of nucleic acid, basic amino acid and hyaluronate in a specific proportion, the preparation process is optimized, and the prepared hyaluronic acid nano-microspheres are high in hyaluronic acid adding amount, high in skin permeability and good in skin care effect. The stability is good, and the application requirements in transdermal drug delivery drugs, skin care products and other products are met. Meanwhile, a non-covalent binding mode is adopted for preparing the nano-microspheres, the preparation operation is simple, the gelling property of the hyaluronate is effectively improved, the sticky feeling under high content is improved, and the application scene of hyaluronic acid in the field of skin care products is widened.

The present application relates to: a culture medium composition for microorganisms of Corynebacterium species, in which part of ammonium sulfate is replaced with a different ammonium-containing compound; and a method for producing a basic amino acid by using the culture medium composition.

The application discloses a preparation method of an immune protein extract of colostrum with tumor inhibition efficacy, and comprises the following steps: (1) raw material selection; (2) flocculation of casein; (3) sugar removal; (4) ultrafiltration membrane filtration; (5) directional hydrolysis; (6) cation exchange resin adsorption; (7) desalination; and (8) freeze drying. The extract of the application is rich in hydrophobic amino acid and alkaline amino acid hydrolysis fragments of the immune protein of colostrum, and has stronger antioxidant, immune enhancement and tumor inhibition activities. Different from common immune proteins of colostrum, the extract plays the anti-tumor activity as a result of the combined action of its double effects of immune enhancement and tumor cell growth inhibition.

The present invention provides: a Hyal1 variant in which, in wild-type human hyaluronidase Hyal1 comprising glutamic acid 131 as a catalytic amino acid, at least one amino acid among amino acids adjacent to the catalytic amino acid, i.e., glutamic acid 131 in primary and tertiary structures is substituted with an acidic, polar or basic amino acid; a method for producing the Hyal1 variant; a nucleic acid applicable to the production of the Hyal1 variant; an expression vector; a host cell; and a Hyal1 variant preparation or use thereof. The hyaluronidase Hyal1 variant of the present invention can effectively degrade hyaluronic acid not only at acidic pH but also at neutral pH, and thus is highly applicable.

The present invention discloses a method for preparing a nickel oxide thin film, its product and application, belonging to the technical field of photovoltaic materials and devices. The preparation method of the present invention includes: providing a homogeneous aqueous solution containing a nickel source compound and a basic amino acid, and chemically bath-depositing the homogeneous aqueous solution on the surface to be coated of a substrate, so that a nickel hydroxide film layer is formed in-situ on the surface to be coated, and then annealing the nickel hydroxide film layer to generate a nickel oxide thin film. By introducing a basic amino acid into the nickel source chemical bath aqueous solution for chemical bath deposition, the present invention can not only effectively and reasonably adjust the nucleation rate of nickel hydroxide by forming multi-dentate coordination with moderate strength between the basic amino acid and nickel ions, but also prevent the aggregation of nanoparticles through steric hindrance effect, effectively improving the dispersion effect of nanoparticles. Thus, the deposition behavior of nickel hydroxide nanoparticles is synergistically optimized in two aspects, and finally the controllable preparation of a nickel oxide thin film with uniform density and good crystallinity is achieved.

The invention relates to a hydrophilic adhesive based on lipoic acid derivative sodium salt and a preparation and debonding method thereof, the adhesive is synthesized by selecting biological source small molecule lipoic acid and basic amino acid glycine as main agents and using urotropine as a dopant, and the mass ratio of the main agents to the dopant is 1: (0-1). The adhesive can be stored in the form of an aqueous solution and is convenient to transport and use. The adhesive is suitable for adhesion between hydrophilic surfaces, when the adhesive is used, only a small amount of adhesive is needed, after moisture is removed through a simple heating process, the adhesive bearing capacity with the maximum self weight being 2 * 107 times and the maximum shear adhesive strength being about 800 kPa can be achieved, easy debonding can be achieved when the adhesive is placed in water, and the reversible adhesion requirement is met. Compared with the traditional adhesive, the adhesive provided by the invention not only has excellent performance, but also can effectively reduce environmental pollution, and is a green, environment-friendly and efficient novel adhesive solution.

This invention discloses a cyclic lipopeptide delivery system, comprising a cyclic lipopeptide carrier and nucleic acid; the head of the cyclic lipopeptide carrier is composed of heptapeptides R1R2R2R3R4R2R2 linked together by amide bonds to form a ring, and the hydrophobic tail of the cyclic lipopeptide carrier is composed of a fatty acid with a carbon chain length of 6-44 forming an ester bond with the hydroxyl group on the head amino acid R3, with the following general structural formula: where R1 is a basic amino acid, including one of histidine (His), lysine (Lys), or arginine (Arg); R2 is a hydrophobic amino acid, including one of leucine (Leu), isoleucine (Ile), or valine (Val); R3 is a hydrophilic amino acid, including one of tyrosine (Tyr), serine (Ser), or threonine (Thr); R4 is one of glutamate (Glu) or glutamine (Gln); n is an integer from 5 to 43; the cyclic lipopeptide carrier encapsulates the nucleic acid drug to form cyclic lipopeptide-nucleic acid nanoparticles.

Provided are: a DNA polymerase mutant having reverse transcriptase activity, the DNA polymerase mutant including a sequence consisting of twelve specific amino acids A1-A12, wherein the DNA polymerase mutant having reverse transcriptase activity is characterized in that the A3 and / or A10 amino acid is substituted by a basic amino acid residue different from that prior to the introduction of mutation; a kit and a composition including the DNA polymerase; a method for producing the DNA polymerase; and a method for modifying an existing DNA polymerase having reverse transcriptase activity.

To provide food compositions and the like for inhibiting protein glycation that exhibit excellent anti-glycation properties, particularly, protein glycation inhibitors that exhibit anti-glycation properties against a wide range of advanced glycation end products, have antioxidant properties, and are resistant to coloring when used in cosmetics and the like, and are highly safe and biocompatible.SOLUTION: Provided is a protein glycation inhibitor characterized in that the constituent amino acids are selected from the group consisting of acidic amino acids, basic amino acids, hydroxy amino acids, branched-chain amino acids, and antioxidant amino acids, and that the constituent amino acid on the C-terminus side contains a dipeptide or a salt thereof, which is an antioxidant amino acid, as an active ingredient.SELECTED DRAWING: None

This invention discloses a method for preparing a Schiff base corrosion inhibitor for AZ91D magnesium alloy coolant. The method involves adding an ethanol or acetone solution of the ketone-containing heterocyclic compound dropwise to an aqueous solution of the alkaline amino acid at a molar ratio of 1:1 to 1.5. The reaction is carried out at 40–80°C for 4–36 hours, followed by concentration, extraction with glacial ethyl acetate, washing with glacial ethyl acetate, and drying to obtain the corrosion inhibitor. Further, the corrosion inhibitor is formulated into a coolant specifically for AZ91D magnesium alloy. This coolant is composed of a mixture of raw materials with the following weight percentages: 0.1–2% corrosion inhibitor, 39–60% deionized water, and 39–60% ethylene glycol. This invention features a simple preparation process, and the obtained corrosion inhibitor can be stored for a long time, exhibits good thermal stability, strong oxidation resistance, low conductivity, high corrosion inhibition efficiency, and good corrosion inhibition effect on AZ91D magnesium alloy.

The invention relates to the technical field of biological detection, and discloses a sample diluent and application thereof and a kit, pure water is taken as a solvent, and the sample diluent at least comprises 15-80 g / L of soluble sodium salt, 0.05-0.5 g / L of soluble potassium salt, 8-15 g / L of amino acid, 0.2-1 g / L of goat serum albumin, 0.2-1 g / L of surfactant, 0.5-2 g / L of trehalose and 0.5-2 mL / L of Proclin-300 according to concentration, the sample diluent provided by the invention can weaken non-specific binding of impurities in a blood sample and a target analyte, so that the accuracy of a final detection result is improved.