456 results about "Lecithin" patented technology

The invention belongs to the field of biological medicines, and relates to a drug-loaded nano-vesicle as well as a preparation method and application thereof. The drug-loaded nano-vesicle comprises a vesicle core and a drug-loaded nano-vesicle, wherein the vesicle core comprises siRNA (small interfering Ribonucleic Acid) capable of specifically targeting and silencing an NR1D1 gene; the vesicle membrane is formed by fusing an erythrocyte membrane, a macrophage membrane, cardiolipin, cholesterol and lecithin. The drug-loaded nano-vesicle can specifically target macrophages in a sepsis immunosuppression stage, has an intracellular response release function, recovers BMAL1 and IGF2BP2-ATP6V1B2 / ATP6V0c axis functions by inhibiting NR1D1 expression, reconstructs a macrophage phagocytosis function and lysosome-dependent bacterium removal capability, and can be used for preparing a drug-loaded nano-vesicle with a specific targeting function. The survival rate of sepsis immunosuppression model animals is obviously improved; and the bacterial load is reduced. Compared with a traditional electroporation method, the preparation method disclosed by the invention has the advantage that the encapsulation efficiency of siRNA is remarkably improved.

The invention discloses a preparation method of immunoglobulin composite liposome nanoparticles with a controlled release characteristic, and belongs to the field of food nutrition and functional factors. Cholesterol and sitosterol are creatively used as auxiliary supports of a lecithin liposome skeleton, the stability of an immunoglobulin liposome nanoparticle structure is improved, the slow release property in the simulation effect process is improved, and a pH response type hydrogel film formed based on electrostatic crosslinking is prepared from calcium alginate and chitosan. A more stable double-layer shell-core structure is formed, so that the stability of embedded immune globulin molecules in gastric juice is further improved, and fixed-point slow release in small intestines is realized.

The invention provides tranexamic acid-glutathione-containing compound emulsifiable paste and a preparation method thereof.W1 / O / W double emulsion phase structural design is adopted, reduced glutathione is encapsulated in an acidic inner water core, an oil phase is stabilized through hydrogenated lecithin and sorbitan sesquioleate, an outer water phase contains tranexamic acid, a layered gel network is constructed, and the tranexamic acid-glutathione-containing compound emulsifiable paste is prepared. A submicron dispersion system with the particle size D50 of 0.30-0.80 microns, the polydispersity index of 0.15-0.25 and the viscosity of 2.0-8.0 Pa seconds is realized, the encapsulation efficiency of glutathione is not lower than 70%, the oxygen content of a head space is not higher than 1.0%, and the encapsulation efficiency of glutathione is not lower than 70%. The three technical contradictions of coupling conflict between a high-yield viscoelastic structure and low-shear damage kernel integrity, coexistence of fresh and cool low-viscosity skin feeling and high-barrier anti-oxidation and anti-leakage and opposite low-surface-activity sensitive skin compatibility and submicron low-PDI dispersion stability are solved; the traditional Chinese medicine composition has wide application values of improving skin color unevenness, fading color spots, brightening skin color, soothing and repairing.

The invention discloses a composition containing achillea millefolium extract, which is prepared from the following ingredients in percentage by weight: 45 to 55 percent of glycerol, 4 to 6 percent of hydrogenated lecithin, 3 to 5 percent of caprylic / capric triglyceride, 1 to 3 percent of 1, 2-hexanediol, 0.8 to 1.2 percent of achillea millefolium extract, 0.4 to 0.6 percent of ergothioneine and the balance of water. Through precise compounding of the achillea millefolium extract and the ergothioneine, the dual effects of anti-inflammation and skin repair are achieved, flavonoid and organic acid components in the achillea millefolium extract can effectively inhibit release of inflammatory mediators such as IL-6 and TNF-alpha, and sensitive symptoms such as red and swollen and pruritus are relieved.

The application discloses a kind of neutrophil membrane fusion liposome biomimetic nanomedicine carrier and its preparation method and application, belong to medical field.The carrier includes liposome and the neutrophil membrane fused to liposome;Liposome raw materials include DOPE, DPPC and cholesterol, and mass ratio is 6:3:1 in turn;Liposome and membrane protein mass ratio is 1:1.The application establishes quantitative analysis strategy based on NanoFCM, can accurately evaluate the fusion efficiency and fusion uniformity of NM@lipos at single particle level.Based on DOPE, the hybridization efficiency of NM@lipos (D) reaches 92.0%, which is significantly higher than that of NM@lipos (L) based on lecithin (70.1%).In in vivo experiment, the tumor enrichment capacity of NM@lipos (D) is increased by 5.1 times compared with Lipos (D) in 24 hours, and shows significantly prolonged circulation time.

The invention discloses a preparation method of a nano-liposome coated NAD amino acid nutrient solution, and relates to the technical field of liposome amino acid nutrient solution preparation, the preparation method comprises the following steps: S1, preparing raw materials: S1.1, preparing NAD amino acid; s1.2, lecithin: using pure natural lecithin from soybeans and eggs; s1.3, preparing sodium hyaluronate: adopting sodium hyaluronate with low molecular weight; s1.4, preparing an amino acid compound, wherein the amino acid compound contains a plurality of essential amino acids, including glycine, serine and lysine; according to the mask, when the NAD amino acid nutrient solution wrapped by the nano-liposome is applied to the mask, the mask can more effectively permeate into the deep layer of the skin due to the excellent stability and biological activity of the NAD amino acid nutrient solution, and sufficient nutrition and moisture are provided for the skin; meanwhile, due to the strong anti-aging effect, the mask can remarkably improve the skin texture, reduce fine wrinkles and wrinkles, and make the skin more compact, smoother and elastic.

The invention relates to the technical field of biological medicines, and discloses an alpha-ketoglutaric acid composite liposome as well as a preparation method and application thereof. Alpha-ketoglutaric acid is preliminarily entrapped by lecithin and cholesterol to prepare a basic liposome, and then enzymolysis silkworm pupa protein is introduced to the surface of the liposome, so that the enzymolysis silkworm pupa protein and a lipid bilayer are subjected to hydrophobic and hydrogen-bond interaction to form a protein-lipid composite layer, and the stability of a membrane structure is enhanced; and the positively charged arginine modified starch is further deposited on the surface of the liposome to form a polysaccharide-protein-lipid composite layer, so that the electrostatic locking of the negatively charged alpha-ketoglutaric acid is realized, and the encapsulation efficiency and the controlled release performance are further improved. The alpha-ketoglutaric acid composite liposome provided by the invention has the advantages of being high in stability, safe to eat, high in encapsulation efficiency, good in gastric acid resistance stability and the like, has a good slow release characteristic, and can be applied to the fields of sports nutritional supplements, antioxidant products or anti-aging products and the like.

The invention discloses an astragaloside synergistic type composition as well as a preparation method and application of the astragaloside synergistic type composition. Comprising the following components: 8 to 16 parts of astragaloside, 20 to 40 parts of a honeysuckle flower extract, 10 to 20 parts of L-carnitine, 0.1 to 0.5 part of selenium yeast, 3 to 8 parts of diammonium glycyrrhizinate, 5 to 15 parts of taurine, 8 to 20 parts of a fructus forsythiae extract, 2 to 7 parts of vitamin E, 12 to 32 parts of hydroxypropyl-beta-cyclodextrin, 2 to 10.5 parts of maltodextrin, 1 to 7 parts of Arabic gum, 10 to 20 parts of lactose, 1 to 3 parts of zinc gluconate and 2 to 5 parts of magnesium stearate. 1-3 parts of vitamin C, 1-5 parts of xanthan gum and 1-3 parts of lecithin. The composition has a wide application prospect in preparation of veterinary drugs or veterinary food additives.

The lecithin adding device for feed processing comprises an adding tank, a material guide plate and a pump machine, the pump machine is installed on the top of the adding tank, the material guide plate is rotatably installed on the inner side wall of the adding tank through a hinge piece, a mixing shaft is rotatably installed in the adding tank, and the mixing shaft is rotatably installed on the inner side wall of the adding tank. The mixing shaft is fixedly sleeved with a swash plate body, a pressing rod is fixedly installed at the tail end of the material guide plate, balls are installed at the bottom of the tail end of the pressing rod and pressed on the swash plate body, a spray head installation transverse pipe is arranged above the material guide plate, and a plurality of spray heads are installed at the bottom of the spray head installation transverse pipe. And a spray pipe is mounted at a discharge port of the pump machine. The device has the beneficial effects that spraying emulsified lecithin is coated and added through vibration rolling, so that lecithin in feed is more uniformly added, and through a spraying and stirring mode, the stirring time is shortened, the adding efficiency is improved and the discharging speed is high on the premise of ensuring uniformity.

The application belongs to the technical field of drug dissolution and dispersion, and particularly relates to a bunazosin water-based solution preparation and a preparation method. The bunazosin water-based solution preparation provided by the application comprises the following components: bunazosin, gamma-cyclodextrin, lecithin, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, aspartame and water. The above components are mixed to be homogeneous to prepare an oral solution which is uniform, clear and can be stored for a long time. The scheme of the application further enriches the dosage form of bunazosin, improves the convenience of taking bunazosin, and is expected to help improve the oral bioavailability and absorption efficiency of bunazosin. The scheme of the application also provides a reference direction for the mechanism research on the dissolution and dispersion behavior of the insoluble bunazosin macromolecule in a water medium.

The present disclosure relates to suspension-based pharmaceutical formulations for cold and flu medications, and more specifically to high-concentration suspension formulations and soft gel capsule dosage forms having reduced size, as well as methods of preparing the suspension formulations and soft gel capsules thereof.

The invention discloses a hydrogenated lecithin synthesis method based on a nickel catalysis continuous flow strategy, relates to the technical field of preparation of hydrogenated lecithin, and aims to solve the problem that the cost of preparing the hydrogenated lecithin is greatly increased due to the fact that the hydrogen pressure is relatively high and recycling of a catalyst is not considered in an existing method. The preparation method is technically characterized by comprising the following steps: (1) performing heat treatment on moso bamboo powder in a protective gas atmosphere to obtain a carbon carrier; dipping the carbon carrier in an alkali solution, and then carrying out a high-temperature activation reaction in a protective gas atmosphere; an activated carbon carrier is obtained; the preparation method comprises the following steps: loading a nickel source, an auxiliary agent and a structure stabilizer into an activated carbon carrier by dipping to obtain a catalyst precursor, and pyrolyzing the catalyst precursor in a protective gas atmosphere to obtain a Ni / C catalyst, and (2) preparation of hydrogenated lecithin: dissolving lecithin in a mixed solution of dichloromethane and methanol, taking a Ni / C catalyst, filling a catalytic pipeline with the Ni / C catalyst, and carrying out a hydrogenation reaction under hydrogen flow to obtain the hydrogenated lecithin.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of a hydrogenated lecithin acyl serine intermediate. By selecting the specific deprotection agent, the generation of isomers can be effectively reduced, so that the high-purity hydrogenated lecithin acyl serine intermediate is obtained, and the method has the characteristics of simple post-treatment, low cost, environmental friendliness and the like.

The present application belongs to the technical field of daily chemical preparation, and particularly relates to a gynecological gel for inhibiting bacteria, regulating microecological balance and tightening vagina and a preparation method thereof. The gynecological gel comprises the following raw materials in mass fractions: 0.5-1 parts of carbomer, 0.04-0.09 parts of sodium hydroxide, 1-3 parts of collagen, 0.01-0.06 parts of sodium hyaluronate, 0.5-1.5 parts of isomaltooligosaccharide, 2-5 parts of propylene glycol, 0.05-0.3 parts of hydroxybenzoic acid methyl ester, 0.02-0.15 parts of hydroxyphenyl ethyl ester, 0.1-1.5 parts of hydrogenated lecithin, 1-6 parts of 1,3-butanediol, 3-5 parts of glycerol, 0.5-1 part of xanthan gum and 70-90 parts of water. The present application uses buckwheat filtrate to prepare collagen, and the active ingredients in the buckwheat filtrate can penetrate the cell membrane of pathogenic bacteria to play an antibacterial role; the collagen can repair the vaginal mucosa barrier and reduce the adhesion and invasion of pathogenic bacteria; therefore, after being compounded with the raw materials such as carbomer, sodium hydroxide, sodium hyaluronate, isomaltooligosaccharide and propylene glycol, the multiple components can synergistically promote the synthesis and repair of collagen fibers and improve the elasticity of tissues.

This disclosure relates to crystalline forms of 3-acyl-buprenorphine derivatives and sustained release injectable pharmaceutical compositions for treatment of opioid dependence, pain or depression, including an aqueous suspension of crystalline 3-acyl-buprenoprhine, or a pharmaceutically acceptable salt thereof, wherein the composition does not include an organic solvent, a polylactide polymer, a polyglycolide polymer, or a copolymer of polylactide and polyglycolide. This disclosure also includes 3-acyl-buprenoprhine or a pharmaceutically acceptable salt thereof prepared in a controlled release matrix, including poly(lactide-co-glycolide), sucrose acetoisobutyrate, lecithin, diolein and a combination of two or more thereof.

This invention discloses a firming and wrinkle-reducing eye cream, comprising a moisturizer, a whitening agent, a skin repair additive composition, a thickener, a preservative, a film-forming agent, a skin moisturizer, and a surfactant. The weight ratio of the moisturizer, whitening agent, anti-aging additive composition, thickener, preservative, film-forming agent, skin moisturizer, and surfactant is 20:1:2:3:0.3:0.5:1:0.2. The moisturizer includes butylene glycol, glycerin, polydimethylsiloxane, and hydrogenated polyisobutylene. The skin-repairing additive composition includes hydroxypropyl tetrahydropyranotriol, adenosine, cell growth factors, ceramides, and salicylic acid, comprising olefins, betaine, trehalose, 1,2-hexanediol, hydrogenated lecithin, allantoin, and Euglena galactosides. The film-forming agents include polyacrylamide, cyclohexylsiloxane, and polydimethylsiloxane alcohol. The emollients include C13-14 isoparaffins, polydimethylsiloxane / vinyl dimethylsiloxane crosspolymers, and cyclopentamethoxysiloxane. This invention can repair cells and provide long-lasting anti-wrinkle and whitening protection for the corners of the eyes.

The invention provides a whitening composition containing a jasmine extract as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The whitening composition is prepared from the following components in parts by weight: 1 to 10 parts of nicotinamide; 0.1 to 5 parts of taurine; 0.1 to 3 parts of lecithin; 0.01 to 2 parts of inositol; 0.01 to 1 part of ceramide NP; 0.1 to 3 parts of tranexamic acid; 0.01-2 parts of glutathione, 0.1-5 parts of a jasmine flower lactobacillus fermentation extract and 20-60 parts of water. By controlling the types and mass ratio of the specific components, especially the mass ratio of lecithin to tranexamic acid, inositol to glutathione, and nicotinamide to taurine to jasmine lactic acid bacteria fermentation extract, the obtained composition not only can inhibit melanin generation and transport, but also can promote permeation of effective components, so that the anti-aging effect of the composition is improved, and the anti-aging effect of the composition is improved. The content of effective components in the skin is increased, so that the absorption effect and the bioavailability of the product are improved.

This application belongs to the field of biomedicine, specifically relating to a method for preparing an antitumor composition for pets, aiming to solve the technical problems of low bioavailability, poor stability, and poor drug administration compliance of poorly soluble active ingredients in antitumor drugs for pets. The method includes: a raw material pretreatment step, in which curcumin, resveratrol, quercetin, green tea polyphenols, and astragalus polysaccharides are pulverized and sieved separately; an organic phase preparation step, in which egg yolk lecithin and solid lipids are dissolved in an ethanol-acetone mixed solvent, and curcumin and resveratrol are added and dissolved by stirring in a water bath; an aqueous phase preparation step, in which poloxamer F68 is dissolved in purified water and dissolved in a water bath; a high-pressure homogenization step, in which a nanoemulsion containing a solid lipid core is prepared; a moderately polar component encapsulation step, in which quercetin and green tea polyphenols are ultrasonically dispersed and then added dropwise to the nanoemulsion; a freeze-drying step, in which a nano-lyophilized powder is obtained; and an outer hydrophilic component coating step, in which astragalus polysaccharides are sprayed or adsorbed onto the surface of the freeze-dried powder. The composition obtained by this method is a core-shell multilayer nanoparticle with a core consisting of curcumin and resveratrol encapsulated by solid lipids, a middle shell adsorbing quercetin and green tea polyphenols, and an outer shell coated with astragalus polysaccharides. This application utilizes the above-mentioned layered encapsulation technology to achieve stable co-encapsulation of multiple antitumor active ingredients, improve the bioavailability of poorly soluble components, optimize drug stability, and enhance antitumor effects through multi-target synergistic effects. Simultaneously, it endows the composition with immunomodulatory functions and sustained-release properties. The composition can be formulated into a nano-lyophilized powder form, making it easy to add to pet food or formulate into a paste for administration, improving pet drug compliance. Figure 2 is a schematic diagram of the three-layer core-shell nanoparticle structure of the composition of this invention.

The invention provides an application of combined use of xanthan gum, soya bean lecithin and a bitter agent in a bitter placebo matrix used in a traditional Chinese medicine decoction. The invention provides a placebo matrix composition capable of simulating the aftertaste of a traditional Chinese medicine decoction. The decoction comprises the following raw materials in percentage by weight: 0.03-0.04% of a bitterness agent, 0.05-0.2% of xanthan gum and 1.5-3% of soybean lecithin. The invention further provides the modified rheum officinale and coptis chinensis gargle placebo. Aiming at the defects that only instantaneous bitter taste can be generated by simply adding a bitterness agent and the bitter taste fades quickly in the prior art, the invention provides a method capable of actively regulating and remarkably prolonging the bitter taste sensing duration, so that the placebo can realistically reproduce a complete time-intensity curve of'bitter taste in mouth-lasting bitter taste after mouth 'of a traditional Chinese medicine decoction; therefore, the testee is prevented from being broken by bitterness lasting time difference. The method breaks through the limitation of traditional solution simulation, and aims to provide a new thought for preparation of traditional Chinese medicine placebo, further improve the sensory simulation level of the placebo and provide a method and reference for research of similar placebo.

This invention relates to the field of image recognition and detection technology for foodborne pathogens, and discloses a method for identifying Listeria monocytogenes based on image recognition. The identification method includes: acquiring images of chromogenic culture medium plates and converting them to Lab and HSV color spaces; performing adaptive color normalization based on the background region of the culture medium; performing colony instance segmentation on the normalized image and extracting extended regions of interest; extracting saturation distribution sequences along radial rays and detecting halo transition patterns using first-order difference; statistically analyzing halo angle coverage and average transition amplitude, and combining halo quantization feature vectors; inputting the feature vectors into a gradient boosting decision tree classifier to output colony identification results. This invention solves the technical problems of unstable classifier discrimination boundaries caused by color shifts between different batches and the difficulty in detecting halos caused by weak lecithinase reactions.

The application discloses a method for preparing goldfish feed from fermented abalone viscera powder, and comprises the following steps: preparing fermented abalone viscera powder, including raw material pretreatment, strain activation, anaerobic fermentation and final treatment; preparing a formula of the goldfish feed, including fermented abalone viscera powder, spirulina powder, fish meal, soybean meal, rice bran, wheat flour, fish oil, alpha-starch, soybean lecithin, calcium dihydrogen phosphate, vitamin premix, mineral premix, betaine, garlicin, VC-phosphate, lysine and choline chloride; and preparing the goldfish feed, including accurate batching, uniform mixing, moisture adjustment and molding, grading granulation, drying and cooling and grading screening. The fermentation and feed preparation process is simplified, the complicated enzymolysis-fermentation combined process is abandoned, no professional technical personnel are needed, and the household breeders can prepare the feed through simple equipment, and the enterprises can mass-produce the feed; the formula is optimized for goldfishes in different growth stages, is suitable for multiple goldfishes such as golden goldfish and grass goldfish, and has high application flexibility.

This invention discloses a method for producing high-quality sodium caseinate, belonging to the field of food engineering technology. The method includes enzymatic modification, low-temperature alkali conversion, ceramic membrane microfiltration, ultrafiltration desalting and concentration, homogenized spray drying, and fluidized bed agglomeration granulation. Enzymatic modification uses a complex enzyme of endopeptide and phosphatase to hydrolyze bitter peptides and phytic acid at 45–55℃; low-temperature alkali conversion involves gradient alkali addition at 15–25℃ to avoid thermal damage and Maillard reactions; ultrafiltration employs equal-volume dialysis, with water added until the conductivity is ≤500 μS / cm, desalting and removing small-molecule bitterness; finally, agglomeration granulation is achieved by fluidized bed spraying with 0.1%–0.5% lecithin. This invention completely abandons the acid precipitation-alkali dissolution process, coupling enzymatic modification with all-physical membrane separation and purification to produce sodium caseinate that is white in color, pure in flavor, dissolves rapidly in cold water in ≤30 seconds, has an ash content ≤3.5%, reduces wastewater discharge by more than 90%, is environmentally friendly, and suitable for large-scale production.

The application discloses a kind of biological base alcohol type beauty glue and preparation method thereof, it is related to adhesive technical field.The raw material composition of the beauty glue includes biological base polysiloxane, nano zinc oxide, biological base composite mildew inhibitor, hydrophobic fumed silica, titanium acid tetraisopropyl ester, methyl tributyl ketone oxime base silane, nano calcium carbonate, epoxy soybean oil, tea polyphenol;The biological base polysiloxane: raw material includes biological base 1,3-propylene glycol, hydroxyl end-capped polydimethylsiloxane, silane coupling agent;The biological base composite mildew inhibitor: raw material includes lecithin, epsilon-polylysine, tea tree oil, vitamin E.The preparation method of beauty glue includes preparing biological base polysiloxane, preparing biological base composite mildew inhibitor, basic filler dispersion, and preparing beauty glue finished product step.The biological base alcohol type beauty glue prepared in the application has good mildew-proof effect and excellent mechanical properties.

The invention relates to the field of lipidosome technology and skin external preparations, in particular to bionic ceramide coated retinol lipidosome and a preparation method and application of the bionic ceramide coated retinol lipidosome. The liposome is prepared from the following raw materials in parts by weight: 1.0 to 3.0 weight percent of ceramide NP, 1.0 to 3.0 weight percent of ceramide AP, 0.05 to 0.5 weight percent of ceramide EOP, 1.0 to 3.0 weight percent of cholesterol, 0.50 to 2.0 weight percent of meadowfoam seed oil, 3.0 to 10.0 weight percent of hydrogenated lecithin, 1.0 to 3.0 weight percent of retinol, 0.50 to 2.50 weight percent of tocopheryl acetate, 15.0 to 45.0 weight percent of caprylic / capric triglyceride MCT, 1.0 to 5.0 weight percent of propylene glycol, 15.0 to 45.0 weight percent of glycerol and the balance of water, the bionic layered film is constructed by the multi-subtype ceramide, cholesterol and hydrogenated lecithin, the oil phase and an antioxidant system are cooperated, the stability of retinol under light, heat and oxygen is remarkably improved, slow release is achieved, meanwhile, skin tolerance is improved, and the bionic layered film can be widely applied to essence, emulsion, face cream, ampoule and other external skin care preparations.

The invention relates to the technical field of cosmetics, in particular to a preservative-free cosmetic composition for barrier repair as well as a preparation method and application of the preservative-free cosmetic composition. The invention relates to a preservative-free cosmetic composition for barrier repair, which comprises the following components in percentage by weight: 4.0-6.0% of 1, 2-pentanediol; 0.5% to 1.0% of 1, 2-hexanediol; 0.1% to 0.5% of cerayl; 0.5%-1.0% of phytosterol; 4.0%-6.0% of stearic acid; 4.0%-7.0% of hydrogenated lecithin; 0 to 0.3 percent of caryophylline; 0-0.2% of a eucommia ulmoides bark extract; and the balance of water. The composition of 1, 2-pentanediol and 1, 2-hexanediol is adopted to replace a traditional chemical preservative, and on the premise that the preservative effect is achieved, the possibility of causing skin irritation and allergy risks is reduced; ceramide and phytosterol can participate in construction of a skin barrier and supplement and repair a lipid structure of the skin barrier; stearic acid and hydrogenated lecithin form a stable emulsification basis, so that the two long-term contradictory requirements of no chemical preservative stimulation and effective barrier repair are met, and the unification of product safety and efficacy is realized.

The invention relates to a large-particle dog and cat oral health-care functional food wrapped with instant freeze-dried particles and a preparation method thereof, and belongs to the technical field of pet food. According to the scheme, an external spraying system comprises grain base material particles, 0.1 to 0.15 part of lecithin, 0.002 to 0.003 part of monostearin, 0.001 to 0.003 part of vitamin E and 0.8 to 1.2 parts of chicken oil, and an instant freeze-dried particle layer comprises 0.1 to 0.2 part of fucoidan, 0.02 to 0.05 part of lysozyme, 0.04 to 0.08 part of tea polyphenol, 0.02 to 0.04 part of zinc gluconate, 0.05 to 0.1 part of Arabic gum, 0.03 to 0.1 part of glutamine, 0.01 to 0.02 part of vitamin B2, 0.01 to 0.04 part of vitamin B12 and 0.02 to 0.07 part of glycine. The toothpaste can effectively inhibit the formation of dental plaque and dental calculus and remove halitosis.

This application relates to the field of antioxidant skincare products, specifically an astaxanthin essence with natural antioxidant effects and its preparation method. An astaxanthin essence with natural antioxidant effects comprises: an aqueous phase: 15%-30% natural plant extracts, 3%-8% moisturizers, 0.3%-1.5% thickeners, and preservatives; an oil phase: 5%-14% plant oils, 1%-4% lecithin, 0.5%-2% rosemary extract, and 0.3%-1.5% green tea extract; 0.8%-4% astaxanthin liposomes; gum arabic; a pH adjuster; and water; wherein the natural plant extracts include aloe vera juice and cucumber juice. This application aims to improve the stability and bioavailability of astaxanthin and enhance the antioxidant properties of the essence by using natural raw materials and innovative processes; while ensuring the product is natural and gentle, reducing skin irritation, and meeting consumers' demand for high-quality natural skincare products.

This invention provides methods for culturing animal cells and related technologies. [Solution] Animal cells are cultured in the presence of lecithin.

The invention belongs to the field of anti-tumor compounds, and particularly relates to a preparation method of carboplatin-unsaturated fatty acid liposome, which comprises the following steps: S1, preparing lecithin into a lecithin solution; preparing unsaturated fatty acid into a fatty acid solution; preparing carboplatin into a carboplatin solution; s2, adding a lecithin solution and a fatty acid solution into an eggplant-shaped bottle, then adding chloroform or dichloromethane, uniformly mixing, and carrying out rotary evaporation to obtain a phospholipid membrane; s3, taking and preheating a carboplatin solution, adding the carboplatin solution into the phospholipid membrane after preheating, and performing ultrasonic hydration to obtain a liposome solution; s4, performing ultrasonic crushing on the liposome solution; and S5, filtering the ultrasonically crushed liposome solution to obtain the liposome. The invention also discloses an application of the carboplatin-unsaturated fatty acid liposome prepared by the preparation method in preparation of antitumor drugs. The problem that in the prior art, the curative effect and safety of a carboplatin drug are difficult to consider at the same time can be solved, and metastatic tumor cells can be effectively inhibited at low drug concentration.