839 results about "Acne" patented technology

There is disclosed a packaged allograft implant configured for implantation in a human recipient. In an embodiment, the packaged allograft implant includes an acellular dermal matrix sheet having a top surface and a bottom surface in opposition to one another, a perimeter surrounding the top surface and the bottom surface, and a thickness extending between the top surface and the bottom surface. The packaged allograft implant further includes a mesh pattern extending across at least a portion of the top surface and the bottom surface of the acellular dermal matrix sheet, the mesh pattern providing through-holes extending between the top surface and the bottom surface of the acellular dermal matrix sheet, and the mesh pattern having a plurality of mesh lines extending in a first direction and a second direction. The first direction and the second direction are orthogonal to one another so as to allow a given amount of stretch in each of the first direction and the second direction. Other embodiments are also disclosed.

The invention relates to the technical field of image processing, in particular to an image-assisted grading detection method for skin acne, a storage medium and a system.The image-assisted grading detection method comprises the steps that according to the gray value of each pixel point in each suspected defect connected domain, the number of the pixel points in each suspected defect connected domain and the number of the pixel points in a background region, the gray value of each pixel point in each suspected defect connected domain is calculated; screening out a plurality of target connected domains from all the suspected defect connected domains; obtaining a plurality of acne areas according to the number of pixel points in each target connected domain, the gray value of each pixel point and the distance between the centroids of any two target connected domains; according to the number of the pixel points in each acne area and the chain code value of each pixel point on the edge, the face acne grading condition of the patient is obtained. By analyzing the size of each acne area, the rule degree of the edge and the gray difference between the acne area and normal skin, the skin condition is graded in combination with the clustering algorithm, and the accuracy of grading detection of skin acnes is improved.

According to the preparation method of the Huangshan pine needle polyphenol and the acne-removing and inflammation-diminishing essence, the Huangshan pine needle polyphenol is prepared by adopting a microbial solid fermentation method, release of soluble polyphenol substances in Huangshan pine needles is remarkably promoted, and compared with an unfermented group, the polyphenol content of pine needles reaches up to 146.32 + / -2.53 mg / g and is increased by 1.89 times. The pine needle polyphenol component is prepared by adopting ultrasonic-assisted deep eutectic solvent extraction, membrane filtration and separation and purification technologies, the method has the advantages of short extraction time, low extraction temperature, environmental friendliness and the like, the structural integrity of pine needle polyphenol is maintained to the greatest extent, and the antibacterial activity of polyphenol is remarkably improved. The acne-removing and inflammation-diminishing essence containing the Huangshan pine needle polyphenol is soft in formula and high in safety, has remarkable dual effects of moisturizing and acne removing, can effectively inhibit skin inflammation, promote repair of acne skin, maintain the health state of the skin and meet the requirements of people, and can be widely applied to the field of skin care products.

The invention aims to provide an acne precise treatment and drug delivery system based on multi-modal data and feedback control. The system comprises an image acquisition and identification module, which carries out acne focus identification on an obtained skin image based on a deep learning algorithm, and extracts focus feature data; the sensor acquisition module is used for acquiring skin physiological parameters and environmental parameters related to acnes; the multi-modal fusion module carries out fusion processing on the focus characteristic data, the skin physiological parameters and the environmental parameters to generate current acne state parameters; the digital twinborn prediction module constructs a digital twinborn model of the patient according to the current acne state parameters and predicts the development trend of acnes; the individualized treatment decision module formulates an individualized treatment scheme and a corresponding administration dosage according to a prediction result of the digital twinning prediction module; and a set of system capable of realizing multi-source data acquisition, automatic evaluation, prediction analysis and personalized treatment scheme recommendation of the acne of the patient is constructed.

The invention provides an acne-removing and relapse-preventing composition suitable for acne sensitive skin and application of the acne-removing and relapse-preventing composition, and belongs to the technical field of cosmetics. The epigallocatechin gallic acid glucoside, the brazilin, the roselle flower extract, the jujube bark extract, the linseed oil unsaponifiable matter and the guaiacol extract are selected as active ingredients of the acne-removing and relapse-preventing composition and interact with one another, growth of acne-related pathogenic bacteria can be rapidly inhibited, and the skin micro-ecology can be adjusted; skin inflammation in the whole process of acne is effectively inhibited, the effects of preventing and inhibiting inflammation are achieved, the skin barrier is effectively repaired, redness is reduced, meanwhile, the effect of adjusting skin grease balance is achieved, and acne recurrence is prevented; in addition, the acne-removing and relapse-preventing composition also has the effects of removing yellow gas, uniformizing skin color and improving skin roughness, is mild and non-irritating, can be used for sensitive skin, and expands the application range of the acne-removing and relapse-preventing composition.

The invention discloses a preparation method and permeation promotion application of a high-purity sponge bone needle, and belongs to the technical field of sponge bone needles. Comprising the following steps: cutting a natural sponge into pieces, soaking in deionized water, carrying out ultrasonic oscillation, filtering, and cleaning to obtain a pretreated sponge; carrying out enzymolysis on the pretreated sponge with alkaline protease to obtain a primary zymolyte; and carrying out enzymolysis with ginger protease to obtain a secondary enzymolysis product, and carrying out vacuum freeze drying to obtain the high-purity sponge spicule. The natural sponge is subjected to enzymolysis treatment through alkaline protease and ginger protease, and the high-purity sponge spicule is obtained; wheat oligopeptide is grafted on the surface of a sponge spicule, and giant salamander skin collagen, a pomegranate seed extract, a lonicerae flos extract, a centella asiatica extract, an early celery extract, an iris tectorum extract, an oyster shell extract and calcium chloride mixed treatment materials are loaded, so that the repairing effect on skin inflammation acne is improved.

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.

The invention discloses medical soap for sterilizing, relieving itching and removing acne and a manufacturing method thereof, belonging to the field of articles of everyday use. The medical soap is prepared from ingredient A, ingredient B and ingredient C, wherein the ingredient A is prepared from dandelions, folium isatidis, rabdosia rubescens and glabrous sarcandra herb; the ingredient B is prepared from radix angelicae, rhizoma typhonii, white poria, Chinese angelia root tai, radix pseudostellariae, raw milkvetch root, Chinese honeylocust fruit, red paeony root, prepared kusnezoff monkshood root, radices lithospermi, cortex dictamni, thunberg fritillary bulb, fiveleaf akebia fruit, white muscardine silkworms and solanum lyratum; the ingredient C is prepared from soap base, honey and bovine bone marrow oil. The medical soap disclosed by the invention is used for external washing or smearing after being wet by adding water in the morning and evening every day; after a person with smelly feet washes the feet, the medical soap is smeared in gaps between toes; and the medical soap is not suitable for use when the skin is damaged. The medical soap prepared by the invention is a black brown solid body, and has soap medicine odor; the medical soap can be used for nourishing the skin, is antiallergic, beautifies the features, removes acne, relieves itching, removes freckles, clearing heat and deterring sweat; the medical soap can beautify the features, whiten the skin, and remove the acne and the freckles when used for washing the face, and can deter the sweat, remove the smelly odor and treat dermatophytosis when used for washing the feet; and the medical soap has a control effect on the itching toxin which appears after mosquito bite, and has a moisturizing effect for the person having the dry skin.

The invention discloses an acne grading method, system and equipment based on multi-modal fusion and a medium, belongs to facial acne severity grading in the technical field of artificial intelligence, and aims to solve the technical problem of poor facial acne severity grading effect in the prior art. A constructed facial acne grading model comprises a VGG feature extraction module, a multi-modal feature fusion module, an acne feature sensing module and a comprehensive grading module, the VGG feature extraction module extracts facial features in different modals, and the multi-modal feature fusion module models the relation between the facial features in different modals through cross attention for fusion. The acne feature sensing module enhances the sensing of acne features through a cross attention mechanism, and the comprehensive grading module makes a comprehensive and accurate acne severity grading result. According to the method, comprehensive grading of the severity of the acnes is realized by combining the multi-modal face pictures of the patient, and the grading effect of the severity of the facial acnes is greatly improved.

The invention belongs to the technical field of probiotic fermentation, and discloses a preparation method and application of a bifidus yeast fermentation product, and the preparation method of the bifidus yeast fermentation product comprises the following steps: S1, preparing a medicinal phellinus igniarius extract A; s2, preparing a compound extract B of rhizoma anemarrhenae, radix puerariae, sophora flower buds and soapberry; s3, preparing a bifidobacterium fermentation product, namely inoculating the bifidobacterium seed solution into a fermentation culture medium, and culturing and fermenting under an anaerobic condition to obtain a primary fermentation liquid C; and adding A, B and a bifidobacterium seed solution into C, carrying out secondary fermentation, and carrying out post-treatment to obtain the bifidobacterium fermentation product. The obtained bifidus yeast fermentation product can reduce skin oxidative stress and inhibit inflammatory factors IL-6 and 5 alpha-reductase, is beneficial to skin absorption when externally applied, has a good transdermal effect on skin and an excellent oil control effect, can promote water-oil balance of skin, and achieves the technical effects of controlling oil, removing acnes and improving pores.

Provided are a madecassoside composition with a skin repair effect and use thereof. A scratch experiment demonstrated that madecassoside derivatives I and II have good effects in promoting the closure of the intercellular gaps between human keratinocytes. A subsequent transdermal experiment and an assay of skin repair-related factor expression found that the efficacy can be potentially enhanced by compounding the madecassoside derivatives I and II. Formulations were then screened for optimal acne-removing effects in an efficacy study in humans. Finally, the safety and applicability of the derivatives as cosmetic starting materials were verified in a safety study. The studies on madecassoside derivatives facilitate the application and development of Centella asiatica in acne-removing cosmetics.

The invention relates to a root-source anti-acne composition specially researched for teenagers and application thereof, the composition comprises Asiatic pennywort herb and fig fruit extract, and the Asiatic pennywort herb comprises Asiatic pennywort herb extract, asiaticoside and madecassoside. Compared with single centella asiatica, triple centella asiatica has the advantages that the soothing effect is stronger, the effects of controlling oil, removing acnes and the like are more comprehensive, the fig fruit extract can mildly dredge pores and accelerate skin renewal, and the fig fruit extract and triple centella asiatica have a certain synergistic effect on the anti-acne effect.

An acne clearing composition for optimizing skin grease mass, comprising the following components in parts by mass: 0.1-5 parts of a mango leaf extract, 0.1-10 parts of a guaiacum officinale extract, 0.1-10 parts of N-acetylglucosamine, 0.1-10 parts of a yeast extract, and 0.01-5 parts of EUK-134. The components of the acne clearing composition can cooperate with each other, so that optimization of sebum components, maintenance of the stability of proportions of saturated fatty acids / unsaturated fatty acids of the sebum components and inhibition of sebum peroxidation are realized on the whole, thereby achieving the effects of mildly clearing acnes and repairing a sebum layer barrier, and the acne clearing composition has excellent antibacterial performance. Moreover, the acne clearing composition can be added into cosmetics as an active ingredient, so that the cosmetics are mild and non-irritating, and the preparation method for the acne clearing composition is simple and uses easily obtained raw materials, thereby facilitating actual production.

The invention discloses a solid-state flash-release acne-removing composition and an application thereof in a soluble microneedle, and particularly belongs to the technical field of cosmetics. The acne-removing composition is prepared from the following components in parts by mass: 0.5 to 1 part of acne-removing functional component, 4 to 5 parts of hyaluronic acid and 1 to 2 parts of carboxymethyl cellulose, the acne-removing functional component contains a spruce extract, a yeast / zinc fermentation product and dipeptide-15, and the spruce extract is prepared through supercritical extraction. The soluble microneedle containing the acne-removing composition is prepared by utilizing a soluble microneedle preparation technology, and the effects of quickly resisting inflammation, inhibiting bacteria and quickly transdermal repairing can be achieved.

The invention relates to a face-beautifying sunscreen composition and cosmetics, the face-beautifying sunscreen composition comprises a first type of powder, a second type of powder and a film-forming agent, the first type of powder comprises a titanium dioxide mixture, zinc oxide and ferric oxide, and the second type of powder comprises spherical powder, flaky powder and hexagonal hollow tubular powder. The first type of powder and the second type of powder are powder made of different materials; the titanium dioxide mixture comprises spindle-shaped titanium dioxide with the average particle size of 8 nm to 60 nm, spherical titanium dioxide with the average particle size of 200 nm to 300 nm and rod-shaped titanium dioxide with the short diameter of 0.2 mu m to 0.5 mu m and the long diameter of 1 mu m to 5 mu m. The cosmetic prepared from the beautifying and sunscreen composition not only has excellent sunscreen and concealing effects, but also has the effects of beautifying and sunscreen products, can effectively reduce makeup steps, avoids the conditions of skin mud rubbing, acnes and the like caused by accumulation of sunscreen and beautifying products, and is good in makeup holding effect and excellent in makeup effect.

The invention belongs to the technical field of daily chemistry, and provides a triple compound acid composition with skin brightening and acne removing effects, a product and application of the triple compound acid composition and the product, the triple compound acid composition comprises mandelic acid, salicylic acid and succinic acid, and the mass ratio of the mandelic acid to the salicylic acid to the succinic acid is (3-6): (1-2): (1-2). The invention further provides a product containing the composition and application of the product. The composition provided by the invention is synergistically used, has a synergistic effect in the aspect of exfoliating, especially in the aspect of improving the activity of kallikrein 5 (KLK5), not only has the effects of biological skin glowing and exfoliating, but also can efficiently down-regulate the expression of I-type 5alpha-reductase genes, so that the synthesis of sebum is inhibited, and an oil control effect is achieved; in addition, the composition provided by the invention has the effects of brightening, inhibiting bacteria and resisting inflammation, has low sensitization, can be used for removing acnes, takes effect quickly and does not relapse.

The invention provides an acne-removing suspension oil essence and a preparation method thereof. The acne-removing suspension oil essence comprises a water phase and oil phase particles dispersed in the water phase, the oil phase comprises grease, salicylic acid and an oil-soluble acne-removing component; the water phase comprises a thickening agent, a humectant, a water-soluble acne-removing component and water. Compared with a single water type acne-removing essence, the acne-removing suspension oil essence provided by the invention has the advantages that through the matching of the salicylic acid, the oil-soluble acne-removing component and the water-soluble acne-removing component, the acne-removing effect is more efficient, the oil phase of the product can suspend in the water phase, and the coexistence of the oil phase and the water phase is realized under the condition of not adding an emulsifier, so that the oil-water suspension oil essence has a good application prospect. Irritation caused by an emulsifier is reduced, and the acne cream is friendly to acne skin, especially sensitive acne skin.

The invention discloses an acne-removing essence and a preparation method thereof, and particularly relates to the technical field of skin care products, the acne-removing essence comprises the following components by mass: 0.5-5% of salicylic acid; 1%-5% of tartaric acid; 2%-6% of nicotinamide; 0.5%-2% of colloidal sulfur; 1.5%-3% of tea tree essential oil; 1%-2% of hyaluronic acid; 0.5%-1% of ceramide; 1%-3% of glycerol; 1%-2% of trehalose; the salicylic acid is used for penetrating into skin, helping to relieve dead skin cells, reducing inflammation and accelerating skin renewal; the tartaric acid is used for realizing a stripping effect, can remove aged cuticles on the surface of the skin and promote the generation of new cells, so that the problem of acnes is helped to be improved. The acne-removing essence prepared by the invention has a relatively good moisturizing effect, so that skin barrier can be well maintained, keratin metabolism is promoted, grease secretion is inhibited, acne is effectively prevented, inflammatory response of the acne is relieved, and the actual use effect of the acne-removing essence is relatively good.

The invention relates to the technical field of raw materials of skin care products, and particularly discloses a soothing and acne-removing plant extraction composite extracting solution and a preparation process thereof. The preparation method of the soothing and acne-removing plant extraction composite extracting solution comprises the following steps: step 1) mixing glycyrrhiza inflate, centella asiatica, peony roots, seaweed, bergamot and water to obtain a premix; step 2), adding compound bacteria into the premix for fermentation to obtain a fermentation product; the invention discloses a soothing acne-removing plant extraction compound extracting solution and a preparation method thereof.The soothing acne-removing plant extraction compound extracting solution has the advantages that acnes are not prone to relapse, and the soothing acne-removing plant extraction compound extracting solution is prepared by the steps of (1) fermentation, (2) fermentation, (3) filtration and sterilization of a fermentation product to obtain fermentation filtrate and (4) concentration of the fermentation filtrate.

The invention provides a salt-tolerant bacillus and application thereof, the strain is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.29259. A fermentation product obtained by using the strain has remarkable effects of moisturizing, whitening, relieving, resisting oxidation, resisting wrinkles, controlling oil, removing acnes and tightening, and can be applied to cosmetics.

The invention discloses a facial acne grading method based on collaborative mapping multi-scale self-distillation, is applied to the field of computers, and aims to solve the problem of low accuracy of acne severity grading in the prior art. According to the method, the convolutional neural network model is trained by adopting a self-distillation architecture, and a novel distillation module optimization training process is provided in combination with the characteristics of acnes, so that the model can notice the uniqueness of acne images, and the severity grading precision of the model for facial acnes is improved. The method can automatically identify the acne features and grade the severity of the acne features, assists doctors in diagnosis and treatment, and accelerates the healing period of the acne.

The invention relates to an acne-removing composition for fading acne marks and preventing relapse and application thereof. The acne-removing composition comprises a first functional component, an olive leaf extract and a lactobacillus / rye fine powder fermentation product, the first functional component comprises centella asiatica extract, madecassoside and glucose. The centella asiatica extract, madecassoside and the lactobacillus / rye fine powder fermentation product in the composition disclosed by the invention contain various active chemical substances, so that the composition can help to support a skin barrier function, reduce skin sensitivity, improve skin moisture retention capacity, inhibit various inflammatory factors and play a soothing role; the olive leaf extract is rich in natural antioxidants and natural antibacterial components, free radicals can be removed, and the inflammation problem caused by lipid peroxidation is inhibited. The components can be mutually matched and synergistically interacted, so that the acne cream has excellent effects of relieving, resisting oxidation, improving the sensitive and red phenomenon of the acne skin, improving the skin barrier capability of the acne skin and lightening acne marks, has a lasting effect and can prevent relapse.

The invention relates to the field of cosmetics, in particular to an oil-controlling and acne-removing composition and application thereof. The black tea fermentation liquor, the olive leaf extract and the silybum marianum extract are compounded and have a synergistic effect after being combined, a stronger oil control network is formed, and the oil control effect is greatly improved compared with that when a single component is used; a multi-channel and multi-target acne removal path is formed, and the acne removal effect is multi-dimensionally improved compared with that when a single component is used; the skin barrier function can be further enhanced, the water loss is reduced, and the acne skin damaged skin can be recovered more quickly. The black tea fermentation liquor, the olive leaf extract and the silybum marianum extract are all natural plant extracts, are high in safety and are suitable for sensitive skin. After the three components are compounded, the safety is high, the oil-controlling and acne-removing effects of the oil-controlling and acne-removing composition are remarkably improved through the synergistic effect, and the acne problem can be more comprehensively solved.

The invention relates to the technical field of plant essential oil, in particular to natural acne removing and repairing plant essential oil and a preparation method and application thereof. The natural acne removing and repairing plant essential oil is prepared from, by weight, 40-60 parts of mixed oil, 40-60 parts of lavender essential oil, 20-30 parts of tea tree essential oil, 20-30 parts of chamomile essential oil, 20-30 parts of additive liquid, 10-20 parts of grape seed oil, 6-10 parts of pomelo essential oil, 2-4 parts of solubilizer and 0.8-0.12 part of dispersing agent. According to the preparation method, mesophyll tissues in the tea leaves can be separated through enzymolysis, rough vein components in the tea leaves are removed, so that the extract is finer, the smearing comfort of essential oil is improved, the tannic acid component rich in the tea leaves is utilized, and tannic acid can inhibit growth and reproduction of bacteria in acne, so that the skin is kept in a clean state; the acne symptom is improved, and meanwhile, the recurrence rate of the acne is effectively reduced.

The invention relates to the technical field of cosmetics, in particular to a preparation method and application of a supramolecular solvent containing puerarin. The supramolecular solvent containing puerarin comprises puerarin, a hydrogen bond donor and a hydrogen bond receptor, the molar ratio of the hydrogen bond donor to the acceptor is (1-3): (1-2). The puerarin-containing supramolecular solvent formed by using weak interaction force such as hydrogen bonds can effectively solve the problems that puerarin is easy to separate out in the product and poor in transdermal absorption and the like, and meanwhile, the puerarin-containing supramolecular solvent can synergistically promote the effect of puerarin in the oil-control acne-removal product. Cosmetics prepared by adopting the supramolecular solvent prepared by the invention have good oil control and soothing effects, and the preparation process is simple, large-scale production is easy, and the properties are stable.

The invention provides an acne-removing and inflammation-diminishing composition containing nitrogen-doped nano titanium dioxide and a preparation method thereof.The acne-removing and inflammation-diminishing composition is prepared from, by mass, 0.1%-80% of a nitrogen-doped nano titanium dioxide solution, 0.5%-15% of a humectant, 0.05%-5% of a thickening agent and 0.02%-10% of herbal extract, the acne-removing and inflammation-diminishing composition comprises a nitrogen-doped nano titanium dioxide solution, a humectant, herbal extracts and 0.01%-5% of auxiliaries, the content of nitrogen-doped nano titanium dioxide in the nitrogen-doped nano titanium dioxide solution is 0.01%-10%, the nitrogen-doped nano titanium dioxide is particulate matter, and the particle size is 10-60 nm. The acne-removing and inflammation-diminishing composition is formed by combining the nitrogen-doped nano titanium dioxide solution, the humectant, the herbal extracts and the like according to different proportions. The acne-removing and inflammation-diminishing composition has the advantages that the acne-removing and inflammation-diminishing composition has the activity of remarkably improving skin inflammation, is obvious in effect and small in side effect after being used, can play a role under visible light and fluorescent lamps after being sprayed or smeared, does not have toxic or side effects of medicines, and is safe and reliable.

The invention provides a glycyrrhizic acid coated cryptotanshinone nano-micelle as well as a preparation method and application thereof, and relates to the technical field of skin care products. According to the glycyrrhizic acid-coated cryptotanshinone nano-micelle, glycyrrhizic acid is used as a carrier for carrying cryptotanshinone, and glycyrrhizic acid and cryptotanshinone cooperate with each other to jointly play antibacterial, anti-inflammatory and anti-lipid secretion roles, so that the glycyrrhizic acid-coated cryptotanshinone nano-micelle has an obvious synergistic effect; meanwhile, through preparation of the nano-micelle, the problems that existing cryptotanshinone is poor in water solubility and stability and difficult to apply to a water system cosmetic formula are effectively relieved. In addition, detection verifies that compared with single use of cryptotanshinone, the glycyrrhizic acid coated cryptotanshinone nano-micelle can effectively reduce the toxicity of cryptotanshinone to keratinocytes, can intervene in various main pathogenesis of acne, and has antibacterial, acne-removing and repairing effects.

The present invention discloses a staged sustained-release acne patch, which comprises a first layer, a second layer and a third layer in sequence, wherein the first layer contains visual pigments, the second layer and / or the third layer are hydrocolloids, the hydrocolloids in the second layer contain antibacterial agents and / or pore uncloggers; the hydrocolloids in the third layer contain anti-inflammatory agents and / or healing agents, and the first layer is used to fit the skin. The staged sustained-release acne patch in the present invention comprises a first layer containing visual pigments, a second layer containing antibacterial agents and / or pore uncloggers, and a third layer containing anti-inflammatory agents and / or healing agents; the patch is divided into a three-layer design stacked up and down, and the thickness is adjusted to match, so that the patch can achieve the effect of staged sustained release, and can release functional substances in a targeted manner at different stages of the acne growth cycle to promote the healing of acne.

The invention relates to the field of daily cosmetics, health care product raw materials and biology, and discloses lactobacillus rhamnosus JMB235 with the preservation number of CCTCC (China Center for Type Culture Collection) No.M 20232530. The fermentation product of lactobacillus rhamnosus has multiple effects, and can control grease secretion, prevent alopecia, inhibit acne, promote hair growth, inhibit eczema, inhibit inflammation, maintain skin barrier, promote epidermal cell proliferation and differentiation, block sun, repair damaged skin or improve insomnia. The compound can be used for preparing skin external preparations, health-care products, beautifying oral preparations, foods or food additives. And the fermentation product has good stability, is storable and has a wide application prospect.

The invention relates to the field of skin care products, in particular to micro-capsule acne removal cream and a preparation method thereof. The micro-capsule acne-removing cream is prepared from the following components: a humectant, a skin conditioner, a suspending agent, a pH regulator and aloe barbadensis leaf water, behenyl alcohol, arachil alcohol, stearic acid, ethylhexyl hydroxystearate, an artemisia annua extract, pentaerythritol tetrakis (ethylhexanoate) ester, polydimethylsiloxane, tocopheryl acetate and squalane are used as raw materials; and carbomer. The anti-acne cream provided by the invention has the novel appearance of transparent gel and coated particles, can form a micro-capsule structure, and has the advantages of enhancing the anti-acne effect and fully exerting the effects of active substances.