This invention belongs to the field of
biomedical technology, specifically relating to the application of a composition in the preparation of a
drug for the prevention and treatment of
polycystic ovary syndrome (PCOS). The composition comprises bovine
spleen peptide and
adenosine; the
mass ratio of bovine
spleen peptide to
adenosine is 1:(1-2.5). Bovine
spleen peptide, as a bioactive polypeptide, significantly improves
insulin resistance associated with PCOS by targeting and activating the PI3K-Akt signaling pathway and promoting
insulin receptor substrate
phosphorylation.
Adenosine, as a natural
bioactive substance, significantly reduces serum
luteinizing hormone and
testosterone levels in rats and increases
follicle-stimulating
hormone levels, thereby effectively alleviating hyperandrogenism symptoms such as
hirsutism and
acne in PCOS. Furthermore, this composition can significantly improve polycystic
pathological changes in the
ovarian tissue of model rats, reduce the number of cystic dilated follicles, restore the
granulosa cell layer structure, alleviate ovarian stromal
hyperplasia, and promote normal follicular development.