153 results about "Androgen" patented technology

Embodiments of the present invention provide a pharmaceutical intervention in the neonatal pig that inhibits and delays development and activation of the HPG axis, growth of the boar testis and inhibits testicular production of testosterone and androstenone, which prevents the development of aggressive behavior in the maturing boars and the presence of boar taint in the meat. The invention comprises treatment with a combination of an androgen and an estrogen in the newborn male piglet using extended drug delivery methods, with a defined duration of no more than 12 weeks, for the purpose of inhibiting the production of testosterone and androstenone and the accumulation of the boar taint-inducing molecules androstenone and skatole in the fat.

The invention discloses a product capable of treating androgenetic alopecia and / or promoting hair growth and application of exosomes, the product comprises the product capable of treating androgenetic alopecia and / or promoting hair growth, and is characterized by comprising the exosomes obtained by stimulating mesenchymal stem cells through CHIR99021 and minoxidil combined with the exosomes. The disclosure verifies that the exosome obtained by stimulating mesenchymal stem cells through CHIR99021 can promote hair growth and treat androgenetic alopecia, and particularly, the hair growth effect is better when the exosome is combined with minoxidil, so that a product comprising the exosome and minoxidil can treat androgenetic alopecia and promote hair growth is provided.

The invention provides a method for breeding all-male hybrid pelteobagrus fulvidraco through hybridization of double super-male populations, which comprises the following steps: S1, respectively constructing super-male maintenance lines of pelteobagrus fulvidraco and pelteobagrus vachelli by utilizing a sex reversal technology and a sex molecular marker; s2, carrying out artificial propagation on the maintenance line, and propagating the super male fish in batches; s3, partially replacing estrogen with an androgen antagonist for the propagated supermale fish, and synergistically inducing the supermale fish to obtain superfemale fish; s4, performing specific nutrient enrichment cultivation on the super female fish and the super male parent fish; and S5, carrying out reciprocal cross artificial propagation on the super-female fish and the super-male fish between the two super-male groups to obtain a heterozygous super-male group, namely commercial fry of the all-male hybrid pelteobagrus fulvidraco. According to the technical scheme, super-female fishes can be efficiently induced in batches, high-density breeding of parent fishes is achieved, and the effect and efficiency of artificial breeding are remarkably improved; the bred hybrid all-realgar catfish is high in individual uniformity, the growth speed is increased by 20%, and the male rate reaches 100%.

The invention discloses a hematopoietic preparation for treating androgenetic alopecia and a preparation method of the hematopoietic preparation. The hematopoietic preparation is prepared from 5-30 parts of radix polygoni multiflori preparata, 5-30 parts of wine ligustrum lucidum ait, 5-30 parts of mulberry, 5-30 parts of eclipta, 5-30 parts of radix paeoniae alba, 5-30 parts of astragalus membranaceus and 5-30 parts of rhizoma cibotii. The medicine composition and the specific dosage are obtained through a large number of experimental screening and clinical medication experience screening. The whole formula takes tonifying liver and kidney and benefiting essence and blood as the monarch, and takes tonifying spleen and qi and removing heat to cool blood as the minister and assistant, based on the traditional Chinese medicine theory that essence is stored in kidney and is warmed on hair, by inhibiting DHT generation, resisting hair follicle apoptosis and improving scalp microcirculation, the traditional Chinese medicine composition has the remarkable effect of treating androgenetic alopecia, is weak in toxic and side effects, and can be prepared into various clinical dosage forms.

Disclosed are devices and methods for providing local administration of a sex hormone composition in a mammalian body to promote bone remodeling. The device includes an implantable structure configured for placement at a target intraosseous and / or periosteal site in the mammalian body and an effective amount of a sex hormone composition associated with the implantable structure. The sex hormone composition comprises both an estrogen and an androgen.

The present invention relates to use of a JWA polypeptide in the preparation of a drug for resisting androgenetic alopecia. An amino acid sequence of the polypeptide is shown as I or II: I: FPGSDRF-Z; II: X-FPGSDRF-Z, wherein an amino acid S is subjected to phosphorylation modification, and X and Z are an amino acid or an amino acid sequence, respectively. The described JWA polypeptide can directly target integrin molecules onto hair follicle cells and enter the cells to play a role in regulating and controlling hair follicle proliferation, promoting hair growth and the like; the telogen phase of the hair follicles is significantly shortened, and the anagen phase of the hair follicles is prolonged; the hair shaft and follicle volume is increased; and the expression level of the target cell integrin molecule αvβ1 can be improved, and the hair follicle stem cell signal channel MEK / ERK / E2F1 / SP1 / Wnt10a / 10b / β-catenin can be accurately activated.

The invention belongs to the technical field of compositions capable of generating foam, and particularly relates to a composition containing a thiohydantoin compound. The composition contains a compound of formula (I) or a pharmaceutically acceptable salt thereof. The foam composition is convenient to use and high in stability, and can be used for treating, preventing or relieving androgen-mediated disorders, diseases or symptoms, such as acne, hirsutism, sebaceous gland enlargement or androgenetic alopecia.

The invention belongs to the technical field of pharmaceutical preparations, and discloses a minoxidil solution for androgenetic alopecia, which takes a deep eutectic solvent as a core solvent system and contains 1.0-5.0% of minoxidil (active ingredient), 0.1-1.0% of preservative, 0.05-1% of stabilizer, a proper amount of sodium hydroxide (the pH value is adjusted to 4-9) and purified water. According to the minoxidil solution, the solubility of minoxidil is greatly improved through the deep eutectic solvent, the solubility of minoxidil reaches 779.85 mg / ml and is 389.9 times that of water, the deep eutectic solvent is used in the minoxidil solution, ethanol is not contained, the dosage of propylene glycol is as low as 3%, ethanol and high-dosage propylene glycol (20%-50%) in a traditional commercially available formula are prevented from being used, irritation to scalp is reduced, and the minoxidil solution is suitable for scalp care. The minoxidil solution is stable in content after 6 months under the condition of 40 DEG C / 60% RH, the in-vitro transdermal performance of the minoxidil solution is superior to that of a commercially available reference preparation of an ethanol and propylene glycol solvent system, and the minoxidil solution also has the advantages of high stability, remarkable hair growth ability and the like.

This invention discloses a method for large-scale breeding of all-female triploid mandarin fish, comprising the following steps: (1) Preparation of all-female diploid fertilized eggs: using male mandarin fish pseudo-males (XX) induced by androgens and female mandarin fish (XX) selected from superior strains as parent fish, collecting sperm and eggs, mixing the two, adding water at a temperature of 28℃ to activate sperm for fertilization, and obtaining all-female diploid fertilized eggs; (2) Heat shock induction of triploids: after the all-female diploid fertilized eggs are fertilized in the above-mentioned water at a temperature of 28℃ for 8 minutes, they are immediately transferred to water at a temperature of 39~41℃ for 1~2 minutes for heat shock induction, and all-female triploid fertilized eggs are obtained; (3) Seedling hatching and cultivation: the fertilized eggs induced by heat shock in step (2) are transferred to the hatching system for hatching, and then conventional seedling cultivation is carried out to obtain all-female triploid mandarin fish seedlings. The mandarin fish fry produced by this method have a high female rate, triploid rate, and survival rate.

The invention discloses 5 alpha-reductase degradation molecules as well as a preparation method and application thereof, four 5 alpha-reductase degradation molecules can realize thorough removal of zymoprotein by inducing proteasome-dependent degradation of 5 alpha-reductase instead of only inhibiting the activity of the 5 alpha-reductase, so that a more lasting treatment effect is obtained; under the condition of equal dosage, the effect of the 5 alpha-reductase degradation molecule on treating the benign prostatic hyperplasia is superior to that of the traditional inhibitor finasteride; the four kinds of 5 alpha-reductase degrading molecules can effectively degrade 5 alpha-reductase protein and remarkably inhibit development of benign prostatic hyperplasia, have good biological safety and provide new strategies and candidate drugs for treatment of diseases related to 5 alpha-reductase such as benign prostatic hyperplasia, prostatic cancer, androgenetic alopecia and acne.

The invention discloses an ionic liquid for treating androgen-derived alopecia as well as a preparation method and application thereof, and belongs to the technical field of medicines. Through the composite molecular structure design of the quaternary ammonium salt-taurine ionic liquid, the ionic liquid integrates ROS removal, stem cell activation, efficient transdermal and long-acting retention, so that the ionic liquid can directly act on a core pathological link of androgen-derived alopecia; and safe and efficient treatment without drug combination is effectively achieved.

This invention belongs to the fields of biomedicine and cosmetics, and discloses the application of holly glycoside in promoting hair growth and preventing hair loss. Holly glycoside promotes the transition of hair follicles from the telogen phase to the anagen phase (i.e., shortening the telogen phase and prolonging the anagen phase), and inhibits cyclophosphamide-induced apoptosis of hair follicle cells and DHT-induced miniaturization of hair follicles. In androgenetic alopecia, telogen effluvium, and chemical alopecia models, its hair growth-promoting effect is comparable to that of the positive control drug minoxidil. It has broad application prospects in pharmaceutical formulations, cosmetics, skincare products, and beauty products.

Methods and compositions for stimulating hair growth are disclosed. A composition for stimulating hair growth comprises hyaluronic acid. Also provided herein are methods and compositions for treating androgenetic alopecia (AGA). Methods for stimulating hair growth and / or treating AGA comprise administering such compositions into the skin of a patient.

The present application belongs to the technical field of hair loss treatment, and particularly relates to a phototherapy and drug synergistic intervention system for androgenetic alopecia of human scalp. In the system, the drug is angelica extract with a concentration of 0.1-500 ug / mL; the phototherapy light source is a red light LED light source with a wavelength of 600-700 nm; the light irradiance is 2-100 mW / cm 2 ; the light dose is 2-20 J / cm 2 ; the irradiation mode is steady light or pulsed light; and the synergistic intervention mode is that the phototherapy and the drug application are performed synchronously or the phototherapy is performed within 0.5-2 hours after the drug application. Experiments show that the light-drug combined intervention significantly improves cell viability, ATP level, migration ability, IGF1 and VEGF secretion, reduces ROS and MDA levels, inhibits Caspase-3 activity, regulates BCL2 / BAX expression, activates Wnt, Hh and PI3K pathways, and inhibits BMP and TGF-beta pathways. The present application provides a treatment scheme with clear timing and standardization, and realizes safe, non-invasive and efficient hair loss treatment.

The invention provides a special culture medium for prostate cancer organoid and a culture method thereof, and belongs to the technical field of biological medicines. The special culture medium for the prostatic cancer organoid is composed of a basic culture medium and a culture additive, and the basic culture medium does not contain exogenously added Noggin recombinant protein and R-spondin recombinant protein. The culture additive is prepared from a basic fibroblast growth factor, a keratinocyte growth factor, a fibroblast growth factor 10, insulin, a p38MAPK signal channel inhibitor, an insulin-like growth factor 1, B27, nicotinamide, N-acetylcysteine, hydrocortisone, a ROCK kinase inhibitor, retinoic acid, interleukin 6, prostaglandin E2, a eriocin and androgen. According to the special culture medium for the prostatic cancer organoid, the culture success rate is increased while the cost is reduced.

The present disclosure is related to a topical formulation comprising clascoterone in a mixture of aqueous and oily gel phases. The present disclosure further relates to a method of treating or preventing skin conditions such acne vulgaris, acne conglobata, acne fulminans, androgenetic alopecia, hidradenitis suppurativa (also known as acne inversa), hirsutism, cancer-therapy-induced rash, eczema, rosacea, atopic dermatitis, psoriasis, inverse psoriasis, seborrheic dermatitis, acanthosis nigricans, wound, and female pattern hair loss, comprising topically administering to a subject in need thereof an effective amount of the formulation.

The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and / or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect.

The present invention refers to an oral pharmaceutical composition comprising minoxidil having controlled particle size for the treatment of androgenetic alopecia, as well as a medicament, methods for treatment and associated uses.

The invention discloses a cell composition for promoting hair regeneration and application thereof, and belongs to the field of biological medicine, the active component of the cell composition comprises a mixture of hair papilla cells, keratinocytes and stem cell growth factors; wherein the number ratio of the hair papilla cells to the keratinocytes is (1-3): (1-3), and the stem cell growth factor mixture comprises bFGF, KGF, HGF, VEGF, TGF-beta1 and PDGF. The cell preparation disclosed by the invention can be used for improving the hair growth effectiveness and solving different types of alopecia symptoms except for androgen alopecia, has a remarkable treatment effect on androgen alopecia, and has a remarkable effect on treating various alopecia symptoms. The traditional Chinese medicine composition has treatment effects on alopecia areata, alopecia in a resting period, alopecia in a growing period, scar alopecia and androgen-derived alopecia.

The invention relates to methods for predicting an outcome for a prostate cancer patient. In particular the method describes a model based on the expression levels of marker genes which can be used to predict the effectiveness of androgen deprivation therapy (ADT). The method allows for treatment suggestions, particularly for those patients where ADT is predicted not to be effective, and alternative treatment may be desirable. The invention further describes kits useful for use in the described methods, as well as composition for use in treatment of prostate cancer based on a treatment outcome prediction described herein.

This invention belongs to the field of biomedical materials and skin / hair repair technology, specifically a recombinant collagen freeze-dried composition targeting hair follicle functional sites, its preparation method, and its application. The composition includes recombinant human collagen, selected from recombinant type III collagen containing a Wnt-binding domain, recombinant type XVII collagen containing an NC16A domain, or a combination thereof; a freeze-drying protectant composed of trehalose and mannitol in a mass ratio of 1:2 to 2:1; and a buffer system, a phosphate buffer with a pH of 6.5-7.5 and a concentration of 5-20 mM. This invention provides precise hair follicle targeting and efficacy far exceeding that of ordinary collagen. It is effective for androgenetic alopecia, telogen effluvium, and diffuse thinning hair loss. It can be used for individuals with scalp micro-damage and sensitive scalps, simultaneously improving the scalp microenvironment and preventing hair loss from the root. Furthermore, its long-term stable effects have been verified over multiple time points.

The invention relates to a method for simultaneously detecting various steroid hormones in serum, which comprises the following steps: extracting hormones in serum by a liquid-liquid extraction method; a derivatization reagent is added into the extracted hormone, an oximation reaction is carried out, and the derivatization reagent comprises quaternary ammonium oxygen amine; the hormone after oximation reaction is injected into a two-dimensional liquid chromatography-tandem mass spectrometry system for detection, the hormone is enriched on a one-dimensional chromatographic column, and then the enriched hormone is subjected to back flushing and transferred to a two-dimensional chromatographic column for analysis. According to the method, the backwashing transfer two-dimensional liquid chromatography-tandem mass spectrometry and the derivatization reaction are combined, various steroid hormones including progestational hormone and androgen can be detected at the same time, and the method has the advantage of being high in detection sensitivity.

The application relates to the technical field of drug delivery, in particular to a microemulsion delivery system and a preparation method and application thereof. The microemulsion delivery system comprises a dispersed phase, an interface film wrapping the dispersed phase and a continuous phase; a complex formed by the continuous phase and the interface film is dispersed in the continuous phase; the dispersed phase comprises rosemary oil and quercetin; and the continuous phase comprises adenosine and a buffer salt solution. The microemulsion delivery system has high drug loading, good transdermal performance and obvious therapeutic effect on androgenetic alopecia.

The invention discloses an application of wool fat in preparation of an anti-alopecia product. The alopecia comprises androgenetic alopecia. The product comprises wool fat and auxiliary materials. Candidates are dug from an existing skin care product raw material library, the treatment effect of the wool fat on androgenetic alopecia is verified through in-vivo and in-vitro experiments, a brand new application of the wool fat is provided, it is verified that the wool fat is good in safety through long-term external use of a human body, the local precise effect can be achieved through a transdermal delivery system, and the application range is wide. The systematic risk of oral medicine is avoided. The invention proves that the lanolin has the effect of treating the androgenetic alopecia, and compared with the existing single-mechanism treatment medicine, the lanolin has smaller side effects in the aspect of treating the androgenetic alopecia and has good tolerance after being used for a long time.

The invention relates to a method for detecting various free androgens in serum, which comprises the following steps: carrying out ultrafiltration treatment on a sample to obtain an ultrafiltration solution; magnetic beads are added into the ultrafiltration solution, and androgen is extracted through magnetic solid-phase extraction; adding a derivatization reagent containing quaternary ammonium oxygen amine into the extracted androgen, and carrying out oximation reaction; and injecting the solution after oximation reaction into a high performance liquid chromatography-tandem mass spectrometry system for detection. The method provided by the invention has excellent specificity and sensitivity, the linear fitting correlation coefficient (r) is greater than 0.99, the recovery rate of the extract is higher than 95.1%, the precision and accuracy measured by relative errors and variable coefficients both meet the regulations of the clinical and laboratory standard association (CLSI), and a stability test proves that under typical clinical treatment conditions, the analyte loss is extremely small.

The application belongs to the technical field of genetic engineering, and particularly relates to a recombinant humanized type XVII collagen for promoting hair growth, a preparation method and application. An amino acid sequence of the recombinant humanized type XVII collagen is shown as SEQ ID NO. 1. The recombinant protein retains multiple key functional sites of human type XVII collagen, has high biological activity, can significantly promote the proliferation and migration of fibroblasts, and can effectively promote the hair regeneration of an androgenetic alopecia model animal. Specifically, the hair coverage and hair length of the animal are statistically significantly increased. The recombinant humanized type XVII collagen prepared by the application has good biological safety and application adaptability, and can be widely applied to the fields of drugs, cosmetics and health products for promoting hair growth, and has good industrial application prospects.

The present application relates to a kind of chlorella active ingredient-containing anti-hair loss shampoo and its preparation method.The chlorella active ingredient-containing anti-hair loss shampoo includes chlorella active ingredient, anti-hair loss active composition, surfactant, scalp barrier repair composition and deionized water;The scalp barrier repair composition includes the combination of ectoine, ceramide and sodium hyaluronate.The anti-hair loss shampoo of the present application is complementary with each component, and realizes the cleaning regulation, system stability, reduces irritation, activates follicle, improves microcirculation and other multiple ways synergistic effect of anti-hair loss and cleaning effect, the target point of the active ingredient of the product is clear, suitable for androgenic alopecia, alopecia areata, telogen effluvium and other various types of hair loss, in addition, the product of the present application is light in texture, not greasy, and there is no irritation after use.

This invention relates to an exosome composition loaded with rapamycin, its preparation method, and its application. The invention uses exosomes loaded with rapamycin to prepare the exosome composition, wherein the exosomes are lemon exosomes. Rapamycin is loaded onto lemon exosomes via electroporation to obtain the exosome composition loaded with rapamycin. The rapamycin in this composition can be used to treat androgenetic alopecia. Lemon exosomes can improve the local stability and delivery efficiency of rapamycin, and can also scavenge or reduce intracellular reactive oxygen species levels. The combination of these two factors can provide efficient and targeted treatment for androgenetic alopecia.