37 results about "Androgen" patented technology

This invention discloses a method for large-scale breeding of all-female triploid mandarin fish, comprising the following steps: (1) Preparation of all-female diploid fertilized eggs: using male mandarin fish pseudo-males (XX) induced by androgens and female mandarin fish (XX) selected from superior strains as parent fish, collecting sperm and eggs, mixing the two, adding water at a temperature of 28℃ to activate sperm for fertilization, and obtaining all-female diploid fertilized eggs; (2) Heat shock induction of triploids: after the all-female diploid fertilized eggs are fertilized in the above-mentioned water at a temperature of 28℃ for 8 minutes, they are immediately transferred to water at a temperature of 39~41℃ for 1~2 minutes for heat shock induction, and all-female triploid fertilized eggs are obtained; (3) Seedling hatching and cultivation: the fertilized eggs induced by heat shock in step (2) are transferred to the hatching system for hatching, and then conventional seedling cultivation is carried out to obtain all-female triploid mandarin fish seedlings. The mandarin fish fry produced by this method have a high female rate, triploid rate, and survival rate.

It refers to a composition for promoting hair growth, which comprises isolated and expanded MSCs, preferably adipose derived stem cells, ATP and a pharmaceutically acceptable vehicle. It further refers to a kit of parts comprising individual vials with MDCs and ATP. It refers also to said composition or said kit for use in androgenic alopecia. It further refers to cosmetic or non-therapeutic use of said composition or said kit for promoting hair growth. It further refers to isolated and expanded MSCs, preferably adipose derived stem cells, for use in promoting hair growth and for the prevention and / or treatment of androgenic alopecia.

This invention belongs to the fields of biomedicine and cosmetics, and discloses the application of holly glycoside in promoting hair growth and preventing hair loss. Holly glycoside promotes the transition of hair follicles from the telogen phase to the anagen phase (i.e., shortening the telogen phase and prolonging the anagen phase), and inhibits cyclophosphamide-induced apoptosis of hair follicle cells and DHT-induced miniaturization of hair follicles. In androgenetic alopecia, telogen effluvium, and chemical alopecia models, its hair growth-promoting effect is comparable to that of the positive control drug minoxidil. It has broad application prospects in pharmaceutical formulations, cosmetics, skincare products, and beauty products.

Methods and compositions for stimulating hair growth are disclosed. A composition for stimulating hair growth comprises hyaluronic acid. Also provided herein are methods and compositions for treating androgenetic alopecia (AGA). Methods for stimulating hair growth and / or treating AGA comprise administering such compositions into the skin of a patient.

The present application belongs to the technical field of hair loss treatment, and particularly relates to a phototherapy and drug synergistic intervention system for androgenetic alopecia of human scalp. In the system, the drug is angelica extract with a concentration of 0.1-500 ug / mL; the phototherapy light source is a red light LED light source with a wavelength of 600-700 nm; the light irradiance is 2-100 mW / cm 2 ; the light dose is 2-20 J / cm 2 ; the irradiation mode is steady light or pulsed light; and the synergistic intervention mode is that the phototherapy and the drug application are performed synchronously or the phototherapy is performed within 0.5-2 hours after the drug application. Experiments show that the light-drug combined intervention significantly improves cell viability, ATP level, migration ability, IGF1 and VEGF secretion, reduces ROS and MDA levels, inhibits Caspase-3 activity, regulates BCL2 / BAX expression, activates Wnt, Hh and PI3K pathways, and inhibits BMP and TGF-beta pathways. The present application provides a treatment scheme with clear timing and standardization, and realizes safe, non-invasive and efficient hair loss treatment.

The invention relates to methods for predicting an outcome for a prostate cancer patient. In particular the method describes a model based on the expression levels of marker genes which can be used to predict the effectiveness of androgen deprivation therapy (ADT). The method allows for treatment suggestions, particularly for those patients where ADT is predicted not to be effective, and alternative treatment may be desirable. The invention further describes kits useful for use in the described methods, as well as composition for use in treatment of prostate cancer based on a treatment outcome prediction described herein.

This invention belongs to the field of biomedical materials and skin / hair repair technology, specifically a recombinant collagen freeze-dried composition targeting hair follicle functional sites, its preparation method, and its application. The composition includes recombinant human collagen, selected from recombinant type III collagen containing a Wnt-binding domain, recombinant type XVII collagen containing an NC16A domain, or a combination thereof; a freeze-drying protectant composed of trehalose and mannitol in a mass ratio of 1:2 to 2:1; and a buffer system, a phosphate buffer with a pH of 6.5-7.5 and a concentration of 5-20 mM. This invention provides precise hair follicle targeting and efficacy far exceeding that of ordinary collagen. It is effective for androgenetic alopecia, telogen effluvium, and diffuse thinning hair loss. It can be used for individuals with scalp micro-damage and sensitive scalps, simultaneously improving the scalp microenvironment and preventing hair loss from the root. Furthermore, its long-term stable effects have been verified over multiple time points.

The application relates to the technical field of drug delivery, in particular to a microemulsion delivery system and a preparation method and application thereof. The microemulsion delivery system comprises a dispersed phase, an interface film wrapping the dispersed phase and a continuous phase; a complex formed by the continuous phase and the interface film is dispersed in the continuous phase; the dispersed phase comprises rosemary oil and quercetin; and the continuous phase comprises adenosine and a buffer salt solution. The microemulsion delivery system has high drug loading, good transdermal performance and obvious therapeutic effect on androgenetic alopecia.

The application belongs to the technical field of genetic engineering, and particularly relates to a recombinant humanized type XVII collagen for promoting hair growth, a preparation method and application. An amino acid sequence of the recombinant humanized type XVII collagen is shown as SEQ ID NO. 1. The recombinant protein retains multiple key functional sites of human type XVII collagen, has high biological activity, can significantly promote the proliferation and migration of fibroblasts, and can effectively promote the hair regeneration of an androgenetic alopecia model animal. Specifically, the hair coverage and hair length of the animal are statistically significantly increased. The recombinant humanized type XVII collagen prepared by the application has good biological safety and application adaptability, and can be widely applied to the fields of drugs, cosmetics and health products for promoting hair growth, and has good industrial application prospects.

This invention relates to an exosome composition loaded with rapamycin, its preparation method, and its application. The invention uses exosomes loaded with rapamycin to prepare the exosome composition, wherein the exosomes are lemon exosomes. Rapamycin is loaded onto lemon exosomes via electroporation to obtain the exosome composition loaded with rapamycin. The rapamycin in this composition can be used to treat androgenetic alopecia. Lemon exosomes can improve the local stability and delivery efficiency of rapamycin, and can also scavenge or reduce intracellular reactive oxygen species levels. The combination of these two factors can provide efficient and targeted treatment for androgenetic alopecia.

Disclosed are methods and compositions for treatment of androgenetic alopecia, telogen effluvium, hair shedding, and / or other forms of alopecia. The method involves: a) topically applying a composition including an androgenic agonist, an ADRB2- agonist, and / or a trace amine-associated receptor (TAAR) agonist; or b) orally administering a composition including an androgenic agonist, an adrenoceptor beta 2 (ADRB2) agonist, and / or a TAAR agonist; or c) administering a composition including an androgenic agonist, an adrenoceptor beta 2 (ADRB2) agonist, and / or a TAAR agonist via a transdermal, subdermal, or subcutaneous vehicle.

It refers to a composition for promoting hair growth, which comprises isolated and expanded MSCs, preferably adipose derived stem cells, ATP and a pharmaceutically acceptable vehicle. It further refers to a kit of parts comprising individual vials with MDCs and ATP. It refers also to said composition or said kit for use in androgenic alopecia. It further refers to  cosmetic or non-therapeutic use of said composition or said kit for promoting hair growth. It further refers to isolated and expanded MSCs, preferably adipose derived stem cells, for use in promoting hair growth and for the prevention and / or treatment of androgenic alopecia.

This invention relates to a group of antisense oligonucleotides that specifically inhibit 5α-reductase and their applications, wherein the antisense oligonucleotides are 16-20 bases in length. This invention also relates to the following applications of the antisense oligonucleotides (ASO): (1) preparing preparations that inhibit the expression of 5α-reductase; (2) preparing drugs or drug compositions for treating androgen-induced alopecia.

The present invention relates to a method for obtaining an extract of the leaves of Rosmarinus officinalis (rosemary) involving two stages of maceration, filtration, concentration of the two drained products and drying, guaranteeing an extract comprising mainly hydroxycinnamic derivatives, rosmarinic acid, luteolin, neptin and carnosol, and the use of the extract in cosmetic compositions in the prevention and treatment of androgenetic alopecia, in which the extract of the invention acts through multiple mechanisms of action, and can be used in men and women.

The application discloses application of a compound in preparation of a medicine for treating androgen alopecia, and relates to the technical field of biological medicines. The foreskin mesenchymal stem cell extracellular small vesicle has water-soluble and fat-soluble double-soluble characteristics, can be absorbed through the skin, and is administered in a manner of intravenous administration / mist administration and the like. The foreskin mesenchymal stem cell extracellular small vesicle is used as a carrier to load curcumin, so that the absorption of the curcumin can be effectively improved, the pharmacological effect of the curcumin can be improved, and the targeting and anti-inflammatory efficiency can be improved. Moreover, the compound obtained by loading the foreskin mesenchymal stem cell extracellular small vesicle with curcumin can easily penetrate into the skin, directly acts on the hair follicles damaged by androgen, has a good effect of treating androgen alopecia, and can significantly promote hair regeneration.

The application relates to the field of tissue engineering and regenerative medicine, and particularly discloses a cell-extracellular matrix complex for hair follicle regeneration and a preparation method thereof. The complex comprises autologous hair follicle stem cells, a human scalp-derived acellular ECM scaffold, time-sequentially added growth factors and an anti-scarring component. In preparation, the autologous hair follicle stem cells are first induced by BMP4 and TGF-beta 1 in cooperation, then inoculated into the human scalp-derived acellular ECM scaffold, and the complex is constructed under dynamic culture conditions, and VEGF is added to promote vascularization. The complex can efficiently form a structure-intact hair papilla-like tissue, has good biocompatibility, low immunogenicity and anti-scarring characteristics, and is significantly superior to a traditional collagen scaffold system. The application provides a new regeneration treatment strategy with clear clinical transformation prospects for scaleable preparation for androgenetic alopecia and other hair follicle deficiency diseases.

This invention provides a topical finasteride formulation and its preparation method, belonging to the field of pharmaceutical formulation technology. The topical finasteride formulation provided by this invention is a topical dosage form, comprising finasteride and excipients; after scalp administration, the concentration in hair follicles and the epidermis is 999-5021 pg / mL, and the systemic blood concentration is 17.1-178.9 pg / mL; the systemic blood concentration is 1-10% of that of oral finasteride formulations. The method involves preparing finasteride and excipients, followed by steps of dissolving / preparing the matrix, fine filtration / homogenization, and filling to obtain finasteride topical formulations of different dosage forms. This invention effectively solves the shortcomings of existing finasteride formulations, such as high systemic absorption, high risk of adverse reactions, and difficulty in industrializing the process, making it suitable for large-scale clinical application in androgenetic alopecia, combining efficacy and safety.

The application discloses application of a fermented Gastrodia elata water extract in preparation of a product for preventing and treating androgen alopecia, and belongs to the technical field of probiotic fermentation and application, wherein the fermented Gastrodia elata water extract is prepared from fermented Gastrodia elata by Lactobacillus salivarius AACE1. The fermentation process realizes biological transformation of Gastrodia elata raw medicinal materials, reduces potential irritation of the Gastrodia elata, and makes the product more suitable for long-term scalp care. Animal model efficacy evaluation of the water extract proves that the water extract can significantly improve androgen alopecia symptoms and has a remarkable effect on preventing and treating androgen alopecia.

The application discloses a radial multilayer microneedle sensing system and method for single follicular unit microenvironment analysis, and belongs to the field of skin appendage detection and biological micro-electro-mechanical systems. The system comprises a positioning hole integrated with an optical collimation unit, concentric ring microneedles with a length ratio within a certain range, ring compression protruding structures between the microneedles, a differential negative pressure sampling module and a detection electrode modified with an aptamer probe, which can accurately position the follicle, perform layered puncture, construct a hydraulic barrier to prevent cross-flow, isolate and extract interstitial fluid between deep and shallow layers and target detection of disease markers such as androgen alopecia. The method comprises the steps of optical targeting positioning, compression sealing puncture, differential sampling, in-situ detection and gradient index calculation. The application can improve the spatial detection resolution of the markers, solve the problems of signal dilution and subcutaneous cross-flow, and provide a quantitative tool for follicular pathological research and drug non-diagnostic screening.

Provided are a pharmaceutical combination and the use thereof in the treatment of acne. The pharmaceutical combination contains an antiandrogen, a retinoic acid drug and an antibacterial drug. The pharmaceutical combination has a synergistic effect in the treatment of acne.

A drug combination and its application in the treatment of acne are provided, the drug combination containing an anti-androgen drug, a retinoid drug and an antibacterial drug, the drug combination having a synergistic effect in the treatment of acne.

The application belongs to the technical field of biological medicine, and specifically discloses application of 5-methylcytidine in preparation of a medicine for treating polycystic ovary syndrome, which aims to solve the problem that existing treatment methods are difficult to realize synchronous and coordinated improvement on key pathological phenotypes such as estrous cycle disorder, insulin resistance, and hyperandrogenemia, and the 5-methylcytidine involved is a pyrimidine nucleoside natural product, which is high in safety, low in toxic and side effects, and has unique curative effect in treatment of polycystic ovary syndrome.

The present invention relates to the topical pharmaceutical composition comprising about 0.001% w / w to about 1% w / w latanoprost and about 1% w / w to about 15% w / w cortexolone-17α-propionate and a pharmaceutically acceptable vehicle comprising one or more solvent and process of its preparation. The invention further relates to the method wherein the composition is suitable for preventing and / or treating hair loss and / or stimulating hair growth. in patients suffering from alopecia, in particular androgenic alopecia (AGA).

This invention discloses a hollow nanoparticle composite microneedle for treating hair loss and its preparation method. The hollow nanoparticle composite microneedle includes a backing layer and a needle array disposed on the surface of the backing layer. The backing layer contains a soluble polymer matrix, and the needle array contains drug-loaded hollow nanoparticles and the soluble polymer matrix. The drug-loaded hollow nanoparticles are uniformly dispersed in the soluble polymer matrix. Each drug-loaded hollow nanoparticle includes a protein shell and an internal hollow cavity, with the drug loaded within the hollow cavity. This invention further prepares protein-based drug-loaded nanoparticles into soluble microneedles, significantly improving drug delivery efficiency and increasing the drug's retention time in the skin. Through the synergistic effect of hollow nanoparticles and soluble microneedles, the hair follicle microenvironment is remodeled, significantly improving the treatment effect of androgenetic alopecia and achieving a better hair regeneration effect than commercially available minoxidil formulations.

The present application belongs to the technical field of synthetic biology, and particularly relates to a recombinant collagen XVII for relieving androgen-induced hair follicle damage, a production method and application. The amino acid sequence of the recombinant collagen XVII is shown as SEQ ID NO. 1. The recombinant collagen XVII domain protein is easy to purify, has the functions of significantly relieving androgen-induced hair follicle damage, and promoting the proliferation and migration of human dermal hair papilla cells after androgen damage, and can be widely used in hair regeneration-related drugs, cosmetics or tissue engineering products.

The application relates to the field of medicinal chemistry and discloses a pyrimidine diamine compound and application thereof. The pyrimidine diamine compound is shown as formula I: The pyrimidine diamine compound of the application can be applied to preparing a product for promoting hair growth and / or preventing hair loss, can promote the hair in the resting phase to enter the growth phase, can stimulate hair growth, can inhibit the hair loss caused by a chemotherapy agent, can resist the chemotherapy toxicity and prevent the hair loss caused by chemotherapy, can inhibit androgen, thereby preventing androgen-induced hair loss, can accelerate the natural growth speed of the hair, can increase the growth weight and length of newly-added hair or the remaining hair after hair loss, and the effect is better than that of minoxidil approved by the FDA.

The present invention relates to the use of combination of 5α-reductase inhibitors and prostaglandin analogues for preventing hair loss and / or stimulating hair growth. The present invention also relates to topical composition containing 5α-reductase inhibitors and prostaglandin analogues for preventing hair loss and / or stimulating hair growth on the scalp. The present invention also relates to composition and methods for treating certain hair loss disorders such as androgenetic alopecia.