11results about How to "Activation activity" patented technology

This invention discloses the application of TRIM29 in breast cancer immunotherapy. The inventors discovered that TRIM29 binds to the voltage-dependent anion channel protein VDAC1 in the outer mitochondrial membrane, regulating the opening of the mitochondrial membrane permeability transition pore, leading to mitochondrial calcium efflux, increased cytoplasmic calcium levels, and activation of the transcription factor NFAT, thereby upregulating PD-L1 expression. Interfering with TRIM29 expression downregulates PD-L1 expression. In breast cancer cells, knocking down TRIM29 significantly downregulates PD-L1 levels in tumor cells, activating T cells to recognize and kill tumor cells.

This invention discloses a guanylate cyclase-C (GC-C) activating peptide and its applications, belonging to the field of bioactive peptide technology. The amino acid sequence of the GC-C activating peptide is PFPGPIPN. The GC-C activating peptide of this invention can significantly activate GC-C activity, increasing intracellular cGMP levels. Furthermore, the GC-C activating peptide of this invention can alleviate constipation and abdominal pain symptoms in mice, thereby effectively preventing or improving irritable bowel syndrome (IBS). Therefore, the GC-C activating peptide provided by this invention has advantages such as high activity, safety and non-toxicity, and good water solubility. It can be used as a candidate molecule for alternative or adjuvant drugs in the clinical treatment of IBS, and also as a health product or food to improve constipation or abdominal pain.

The utility model relates to a leavening and baking integrated oven, which belongs to the technical field of ovens and comprises an oven body, a baking chamber is arranged on the upper portion inside the oven body, and two leavening chambers are arranged on the lower portion inside the oven body. Compared with the prior art, the oven has the advantages that the oven body integrates a traditional separated fermentation box and an oven, the fermentation function and the baking function can be integrated, the purpose of one machine with double purposes is achieved, the oven body adopts the vertical layered design, the problem of large occupied space of the oven body can be solved, and through the effect of the electric heating pipe, the oven body is more convenient to use. According to the baking device, baking food can be heated at a high temperature, waste heat in the baking chamber can be transmitted into the three branch pipes through the arrangement of the ventilation pipes and finally enters the corresponding fermentation chambers, yeast is more active in a warm environment, and through the mode, the baking waste heat can be reasonably utilized, so that energy consumption can be reduced.

The invention discloses a method for cultivating high-starch potatoes through grafting, and relates to the technical field of potato cultivation. The method comprises the following specific steps: (1) cultivating a high-starch potato stock and a common potato scion; (2) grafting the rootstock and the scion; (3) grafted plant treatment; (4) domestication treatment: carrying out stress treatment on the grafted seedlings for 10-15 days, then transferring the grafted seedlings outdoors for culture, and harvesting tubers; and (5) screening of high-starch germplasm: selecting tubers with high starch content for planting, repeatedly domesticating for 2-3 generations, and harvesting tubers to obtain the high-starch potato germplasm. According to the method, the high-starch potato seedlings and the common potato seedlings are grafted, aeroponic culture management is performed after grafting, domestication treatment is performed, the starch content of the grafted potatoes can be increased, and after multi-generation domestication, the high-starch potato germplasm is obtained through breeding. According to the method, the variety breeding process is shortened, and the problem that the high-starch potato germplasm is not created by adopting a grafting method at present is solved.

The application discloses a kind of biocompatible materials and preparation method for bionic porous intervertebral fusion cage, belong to intervertebral fusion cage material technical field.A kind of biocompatible materials for bionic porous intervertebral fusion cage, by weight parts includes the following components: polyether ether ketone 65-80 parts, modified functional filler 15-25 parts, hydroxyapatite 8-12 parts, flow modifier 0.5-1 part;The modified functional filler is graphene oxide coated modified barium titanate functional filler.By introducing surface conductive modified nano piezoelectric ceramic particles, realize the effective conversion and transmission of mechanical stimulation to bioelectric signal, this microstructure design makes the insulating polyether ether ketone matrix possess the electric activity of simulating natural bone stress-electric signal response mechanism, so as to be favorable to activate osteoblast activity and promote bone integration of implant interface.

The invention discloses a composite extract for improving sleep and a preparation method thereof, and belongs to the technical field of plant extraction. According to the invention, four medicinal materials of spina date seed, lily, lotus seed and poria cocos which are homologous in medicine and food and have the effect of soothing the nerves are scientifically combined, and the composite extract for improving sleep is obtained by adopting a specific extraction process; according to the technology, active ingredients are efficiently released through the synergistic effect of cellulase, pectinase and acid protease, and the yield of gamma-aminobutyric acid and other sedative substances is remarkably increased through a co-fermentation system of lactobacillus plantarum and saccharomyces cerevisiae; lipid-soluble effective components are extracted by adopting glycyrrhizic acid and rhamnolipid assisted ultrasonic extraction technology, and finally, embedding protection of the active components is realized through a chitosan oligosaccharide-soybean lecithin system, so that thermal degradation and oxidation loss in the processing process are reduced, and compared with a traditional single extraction method, the preparation method has the advantages that the cost is reduced; according to the method, high-yield gamma-aminobutyric acid, jujuboside, triterpenic acid and other active ingredients can be obtained at the same time, and the effect of the composite extract is improved.

The application relates to a self-powered electric stimulation bionic intervertebral disc, belonging to the technical field of implant medical instruments, which comprises an upper end plate, an intervertebral disc core and a lower end plate; the intervertebral disc core comprises an annulus fibrosus, a nucleus pulposus and a collagen fiber transition area; the inner wall of the collagen fiber transition area is provided with honeycomb-shaped holes for contact and separation with the nucleus pulposus to generate electric energy and promote bone tissue fusion; the application generates the electric energy phenomenon according to the friction nanometer generator mechanism; under the influence of the human body multidirectional movement characteristics, the nucleus pulposus in the intervertebral disc core slightly contacts the honeycomb-shaped holes in the inner wall of the collagen fiber transition area due to pressure, contact and separation between the inner wall of the collagen fiber transition area and the nucleus pulposus generates electric energy; the electric signal can activate the bone cell activity, optimize the bone integration microenvironment, promote the exchange of nutrients and the growth and fusion of bone cells, and significantly reduce the risks of postoperative subsidence, loosening and other complications.

The application provides a product recommendation method and device based on a knowledge graph, relates to the technical field of artificial intelligence, and can be applied to the technical field of finance or other technical fields.The product recommendation method based on the knowledge graph comprises the following steps: constructing a customer knowledge graph according to customer characteristics and constructing a product knowledge graph according to product characteristics; obtaining a customer preference vector representation according to the customer knowledge graph; determining that the similarity between a product corresponding to the customer preference vector representation and a product held by the customer is a customer preference similarity; determining the similarity between each product and the product held by the customer as a customer product similarity according to the product knowledge graph; determining a target product similarity according to the customer preference similarity and the customer product similarity, and pushing a target product according to the target product similarity.The application can accurately provide product recommendations for customers, thereby providing personalized services for the customers and activating the activity of the customers.

This invention discloses SFMBT2 The application of genes and bromocriptine in repairing damaged cartilage and preventing osteoarthritis. Experiments have found that the gene expressed in chondrocytes... SFMBT2 The gene helps maintain the normal phenotype of chondrocytes and can mediate the axial regulation of downstream ATF3-PI3K / AKT signaling. Cartilage tissue-specific knockout mice of this gene exhibit a significant spontaneous osteoarthritis phenotype and exacerbate the progression of DMM surgery-induced PTOA. Gene complementation targeting SMBT2 can significantly activate chondrocyte activity. Among various small molecule drugs targeting SMBT2 protein predicted using docking models, bromocriptine can significantly promote the repair of damaged cartilage by activating the biological function of chondrocytes.

The invention belongs to the technical field of liquid fertilizers, and discloses an organic water-soluble fertilizer containing humic acid and fulvic acid as well as a preparation method and application of the organic water-soluble fertilizer. The organic water-soluble fertilizer comprises a composite humic acid matrix, urea, monoammonium phosphate, potassium nitrate, polyglutamic acid, triphenylsilanol, nano silicon, a composite microbial inoculant and disodium ethylene diamine tetraacetate by weight, wherein the composite humic acid matrix is prepared by mixing hydrothermal synergistic conversion humic acid and biochemical fulvic acid according to a ratio of (2-4): 1; the preparation method comprises the following steps: dissolving the basic components, chelating and synergistic, compounding and curing, and treating a finished product, wherein the curing temperature is controlled to be 35-40 DEG C in the compounding and curing stage. Short-term adjustment and long-term stability of soil pH can be considered, the flocculation resistance of a system and the survival rate of the microbial inoculum are improved, and when the microbial inoculum is applied to tomato and grape planting, obstacle soil conditions can be improved, crop growth indexes, stress resistance, yield and fruit quality can be improved, and the microbial inoculum is suitable for drought, saline-alkali and continuous cropping obstacle scenes.

This invention discloses a super-viscous, high-permeability reducing thin-layer tack coat oil, its preparation method, and its application, relating to the field of road engineering technology. The tack coat oil is made from the following raw materials in parts by weight: 60 parts of oil slurry asphalt composition, 5-8 parts of modifier, 30-35 parts of regenerator, 2-5 parts of surfactant, and 0.6-1.2 parts of compatibilizer. The tack coat oil of this invention not only has high initial and forming strength and permeability, but also improves construction efficiency, eliminating the need for pre-spraying and waiting for emulsion breaking. It also has a regeneration and restoration effect on old pavements, activating the activity of oxidized asphalt and repairing bonding failures. Furthermore, this tack coat oil has strong adaptability to the construction environment, making it less likely for subsequent paving machinery tires to lift it, and eliminating the need for a dedicated paver.