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31 results about "Bone cell" patented technology
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Bone cell' Bone cells', which are found within the bone tissue, are responsible for the make-up of the skeleton of vertebrates. They are made up of different bone cells: there is the compact tissue which is the hard outer part of the bone, the cancellous tissue which is all the spongy tissue inside of the compact tissue, and the subchondral tissue which is the smooth tissue at the end of each bone."All About Bone." All About Bone. Ohio State University, n.d. Web. 19 Mar. 2013. Bone cells all work together inside of the bones to help keep up the skeletal system. The bone cells do many things for the skeletal system such as the development of new bones, the maintenance of bones, and the regulation of minerals in the body. Types There are four main categories of bone cells which include: lining cells, which protect the boneOursler, Merry J., and Teresita Bellido Bellido. "B>one Cells." ASBMR Educational Materials. ASBMR Educational Materials, 12 Sept. 2003. Web. 19 March 2013. Osteoclasts Osteoclasts are very large multinucleate cells that are responsible for the breakdown of bones. The breakdown of bone is very important in bone health because it allows for bone remodeling.
Preparation method of corrosion-resistant radial gradient porous bionic bone scaffold
The invention relates to a preparation method of a corrosion-resistant radial gradient porous bionic bone scaffold, and belongs to the technical field of medical machinery. According to the method, firstly, the offset C is redesigned according to the relation between a Gyandroid unit cell mathematical formula S (x, y, z) and the offset C, so that the mathematical formula is improved, and the mathematical formula is suitable for the radial gradient porous scaffold. An improved mathematical formula is adopted, a radial gradient porous cuboid model is generated by utilizing a Python script, and a cylindrical radial gradient porous model is obtained through Boolean intersection operation. Then, the model is subjected to smoothing and repairing treatment, and an initial radial gradient porous scaffold is prepared through a selective laser melting (SLM) forming technology; finally, through sand blasting treatment, the finished radial gradient porous bionic bone scaffold is obtained. The uniform porous scaffold has higher corrosion resistance, longer service life and larger specific surface area, is more beneficial to transmission, survival and attachment of bone cells, and has better performance compared with a traditional uniform porous scaffold.
Owner:KUNMING UNIV OF SCI & TECH
Morphological feature-based turned undyed bone tissue pathological image cell segmentation and cell nucleus identification method
The invention discloses a morphological feature-based cell segmentation and cell nucleus identification method for a turned unstained bone tissue pathological image. The method comprises the following steps of: 1, eliminating tool marks by adopting a tool mark elimination method combining local frequency domain analysis and directional suppression; 2, performing cell segmentation by using a K-means method, and performing morphological expansion and topological analysis on a segmented single cell image to identify a cell nucleus in the single cell image; step 3, calculating morphological characteristic indexes of each region; the method comprises the following steps: establishing a multi-dimensional Gaussian mixture model according to existing bone cell labeled sample information, performing outlier detection according to statistical data analysis, and removing results which do not conform to cell morphology; classifying different regions, and removing non-cell regions; by calculating morphological characteristic indexes of each region, different regions are distinguished according to the indexes, and cells are preliminarily screened. According to the method, high-precision cell segmentation and cell nucleus identification can be carried out on the cut undyed bone tissue pathological image.
Owner:SHANGHAI JIAOTONG UNIV
Method for preparing 3D printing ink by extracting hydroxyapatite from skeletal cells
The invention discloses a method for preparing 3D printing ink from skeleton-derived hydroxyapatite, efficient extraction and printing application of natural HA are realized through skeleton pretreatment, decellularization, nanocrystallization and composite ink preparation technologies, and the method has environmental protection property, emotional value and artistic innovation.
Owner:XIAN MICROPOWER HEALTH MANAGEMENT CO LTD
Biodegradable lipidoids and compositions and methods of use thereof for targeted delivery
The disclosure relates, in part, to biodegradable lipid nanoparticles (LNPs) comprising biodegradable lipidoid compounds and compositions thereof. In certain embodiments, the LNPs selectively target a cell of interest (e.g., an immune cell, stem cell, bone cell, blood cell, fat cell, endothelial cell, cancer cell, tissue cell, nerve cell, epithelial cell, connective tissue cell, and muscle cell, inter alia). In certain embodiments, the disclosure further relates to methods for in vivo delivery of therapeutic agents for the treatment, prevention, and / or amelioration of diseases or disorders using the LNPs of the disclosure.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Dental implant
A dental implant comprises a base main body arranged in a dental implant main body and a guide block arranged at the bottom end of the dental implant main body, the dental implant main body is in threaded connection with the base main body, and the dental implant main body is fixedly connected with the guide block; the dental implant main body comprises a first end head and a vertical part, the first end head is fixedly connected with the vertical part, and a threaded groove is formed in the inner wall of the first end head. The dental implant has the beneficial effects that through the arrangement of the fixing mechanism, the contact area between the dental implant and an alveolar bone can be reduced during installation, so that the heat generated during installation is reduced, the problem of bone cell necrosis easily caused by over-high temperature is avoided, and meanwhile, after the dental implant is installed, the bone cell necrosis can be avoided. The friction force between the dental implant and the alveolar bone can be increased, so that the situation that the dental implant slightly moves in the alveolar bone and synostosis formed between the dental implant and the alveolar bone is damaged when the abutment is rotated is avoided.
Owner:SHANGHAI CHUANGSHIJI MEDICAL TECHNOLOGY CO LTD
Compositions and methods for broad delivery of RNA to tissue
PCT designated stage expiredWO2025049632A1Organic active ingredientsPowder deliveryDiseasePolynucleotide
The present invention relates to lipid nanoparticle (LNP) compositions, and diagnostic or therapeutic polynucleotides, e.g. TERT mRNA, which may be delivered with the LNP compositions in formulations to various tissues and cell types throughout the mammalian body, including stem cells, progenitor cells, germ cells, differentiated cells, or terminally differentiated cells, cancer cells, endothelial cells, epithelial cells, spleen cells, hepatocytes, kidney cells and / or bone cells, e.g., for the diagnosis, prevention and / or treatment of conditions or disease.
Owner:REJUVENATION TECHNOLOGIES INC
Automatic cold light whitening orthodontic accelerator
The utility model belongs to the technical field of orthodontic devices, and particularly relates to an automatic cold light whitening orthodontic accelerator which comprises a use shell and an output head, a cold light lamp is fixedly mounted in the output head, a bite support embedded with the output head is assembled on the surface of the output head, a vibration motor is fixedly mounted on the inner wall of the use shell, and the vibration motor is connected with the output head. One end of an output shaft of the vibration motor extends to the upper surface of the using shell and is fixedly connected with an eccentric wheel in a sleeving mode, and a connecting rod mechanism is arranged on the upper surface of the using shell. According to the automatic cold light whitening orthodontic accelerator, the cold light lamp is arranged in the output head, so that teeth of a user can be whitened. By arranging the connecting rod mechanism, the rotary motion driven by the vibration motor can be conveniently converted into linear motion, so that the frequency output by the vibration motor is output to the output head through the connector, the vibration motor vibrates in the mouth of a user, the osteocyte activity and blood circulation of the user can be promoted, and the discomfort of teeth of the user in orthodontics can be relieved.
Owner:ZHEJIANG HUAQI HAER MEDICAL TECH CO LTD
Nanotextured laser surface treated aggregate
The utility model relates to a kind of nanostructure of laser surface treatment aggregate, wherein the surface of the aggregate is titanium metal, and at least one microchannel with titanium dioxide (TiO2) after cooling is formed by laser melting and sputtering to form molten titanium, at least one microchannel includes: at least one micropore, at least one guide channel, and at least one nano-wall formed at least one nano-bulge layer and at least one nano-wall. The following bone healing and antibacterial index effects and purposes are achieved: A. accelerate bone healing related protein deposition, B. accelerate bone cell attachment, C. induce neovascularization, D. accelerate early calcification and bone mineralization, E. improve nutrient exchange, F. stabilize surface bone structure, and G. resist plaque formation.
Owner:BIOMATE MEDICAL DEVICES TECH +1
Integrated porous backbone prosthesis based on 3D printing technology
PendingCN119184919AImprove connection strengthincrease contact surfaceAdditive manufacturing apparatusJoint implantsHuman bodyStress shielding
The invention discloses an integrated porous backbone prosthesis based on a 3D printing technology. The invention provides an integrated porous diaphysis prosthesis which comprises the following steps: 1, designing the integrated porous diaphysis prosthesis by utilizing a modular design method; 2, the permeability and mechanical property of the contact area are tested, the structure of the contact area is more similar to that of the thighbone through fusion design, and the porous structure provides conditions for bone cell growth; 3, biomechanical analysis and comparison are carried out on the bone cement type diaphysis prosthesis and the integrated porous diaphysis prosthesis, and it is found that the porous diaphysis prosthesis can reduce the stress shielding effect and promote bone tissue growth. The porous diaphysis prosthesis designed by the invention is more compactly attached to the femur and more conforms to the anatomical shape of the human body, and the force line of the lower limbs of the human body is prevented from being changed due to the structure of the prosthesis. The integrated porous backbone prosthesis simulates the structure of a natural bone to a great extent, the comprehensive performance is excellent, and bone cell growth, nutrient substance transportation and mechanical property support are improved to a great extent.
Owner:HEBEI UNIV OF TECH
A method for preparing and using strontium-doped magnesium-bioactive glass
The present application relates to the technical field of bioactive glass, in particular to a preparation method and application of strontium-magnesium-doped bioactive glass, on the basis of selecting suitable raw materials, the co-precipitation method is adopted, strontium element is doped, and magnesium oxide is compoundedly added, so that the prepared bioactive glass has regular properties, good dispersible spherical particles, faster and stronger hydroxyapatite formation capacity, faster ion release rate, and can release calcium, phosphorus and silicon ions in simulated body fluid, form more hydroxyapatite, promote the proliferation and stability of bone cells, and stimulate new bone formation. The strontium-magnesium-doped bioactive glass is used in cooperation with mineral trioxide aggregate (MTA), so that cell adhesion, expression of bioactive enzymes, activity of fibroblasts can be promoted, and the strontium-magnesium-doped bioactive glass can be applied to the repair of human bone and dental pulp tissue.
Owner:GUANGXI XINYE BIOLOGICAL TECH
Carbon-based composite material skull connecting screen plate and preparation method thereof
The invention discloses a carbon-based composite material skull connecting screen plate and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: machining a carbon-based composite material into a skull connecting screen substrate, washing and drying the substrate, firstly performing chemical vapor deposition on a carbon or / and silicon carbide substrate, then performing physical vapor deposition on a metal film layer, and converting the metal film layer into a metal oxide layer by adopting an electrochemical oxidation method, thereby obtaining the carbon-based composite material skull connecting screen. The connecting screen plate can avoid the defects of imaging artifacts and stress shielding existing in metal materials, can enhance the adhesion, proliferation and differentiation capacity of bone cells, and can improve the biocompatibility, wear resistance and mechanical property of the bone cells at the same time.
Owner:HUNAN TANKANG BIOTECH CO LTD
Nanostructure of laser surface-treated bone materials
The present invention provides a nanostructure of a laser surface-treated bone material. [Solution] The surface of the bone material is titanium metal 3, and molten titanium metal is formed by laser sputtering. After cooling, it has at least one microchannel 10 made of titanium dioxide (TiO2). The nanostructure of the bone material includes at least one micropore 12, at least one guide channel 16, at least one nanoprotrusion particle layer 111 formed by at least one nanowall 11, and at least one nanowall. The effects and purposes of improving bone healing and antibacterial indicators are achieved: A. accelerating the deposition of bone healing-related proteins; B. accelerating the attachment of bone cells; C. inducing neovascularization; D. accelerating early calcification and bone mineralization; E. improving the exchange of nutrients; F. stabilizing the surface bone structure; and G. inhibiting plaque formation.
Owner:BIOMATE MEDICAL DEVICES TECH +1
A surface-modified porous iron-based scaffold and its preparation method and application
ActiveCN116407687BMaterial nanotechnologyPharmaceutical delivery mechanismEngineeringBiocompatibility
The present invention relates to the field of biomedical materials, and in particular to a surface-modified porous iron-based scaffold and a preparation method and application thereof. The present invention performs surface modification on an existing porous Fe-based scaffold, regulates the surface morphology and structure of the scaffold, and makes the degradation rate faster without destroying its mechanical properties. Experimental verification shows that the scaffold has good biocompatibility and can promote the proliferation and differentiation of osteoblasts on its surface, thereby achieving a perfect match between the degradation rate of the scaffold in vivo and the bone regeneration rate.
Owner:SICHUAN UNIV
Design method of bionic bone scaffold based on TPMS
The application discloses a design method of a bionic bone support based on TPMS and belongs to the technical field of bionic bone supports. The application is based on G unit and D unit formulas, adjusts a bias function to generate G gradient unit and D homogeneous unit CAD models; uses a fusion function to fuse the G gradient unit and the D homogeneous unit CAD models to generate a GD radial fusion CAD model, adjusts the bias function of the G gradient unit by using an interpolation method to make the GD radial fusion CAD model reach a target average porosity; reduces the wall thickness of the GD radial fusion CAD model to form a GD radial fusion CAD model with wall thickness; then divides the GD radial fusion CAD model with wall thickness into a finite element simulation grid model and outputs an inp format simulation model file; imports the inp format simulation model file into HyperMesh software, repairs and divides the grid and exports an inp file format model. The porous support designed by the application considers different functional grading of natural bone structures and different cell morphological fusion, better meets the mechanical properties of a natural femur, and light weight design increases the specific surface area to provide more space for bone cell adhesion and growth.
Owner:KUNMING UNIV OF SCI & TECH
Preparation method of corrosion-resistant radial gradient porous bionic bone scaffold
The present invention relates to a method for preparing a corrosion-resistant radial gradient porous bionic bone scaffold, and belongs to the field of medical machinery technology. The present invention first redesigns the offset C through the relationship between the Gyroid unit cell mathematical formula S (x, y, z) and the offset C, thereby improving the mathematical formula so that it is suitable for radial gradient porous scaffolds. Using the improved mathematical formula, a radial gradient porous rectangular parallelepiped model is generated using a Python script, and a cylindrical radial gradient porous model is obtained through a Boolean intersection operation. Subsequently, the model is smoothed and repaired, and a preliminary radial gradient porous scaffold is prepared by selective laser melting (SLM) forming technology. Finally, a finished radial gradient porous bionic bone scaffold is obtained by sandblasting. The present invention has stronger corrosion resistance, longer service life and larger specific surface area, is more conducive to the transmission, survival and attachment of bone cells, and has superior performance compared to traditional uniform porous scaffolds.
Owner:KUNMING UNIV OF SCI & TECH
Bone material as well as preparation method and application thereof
PendingCN119524208AImprove mechanical propertiesno toxicityTissue regenerationProsthesisBacillus licheniformisHuman body
The invention provides a bone material and a preparation method and application thereof, and relates to the technical field of medical treatment. According to the invention, bacillus licheniformis ACCC 10236 is adopted for fermentation treatment of flatfish bones for the first time to obtain a new skeleton material, and the material has no potential cytotoxicity, has a certain promotion effect on cell proliferation, and has the potential of promoting bone cell growth. And the fermentation process also improves the mechanical properties of the flatfish bones, so that the flatfish bones are closer to the data of real human bones. The novel bone material is further prepared from polyvinyl alcohol, polylactic acid and fishbone ferment powder, the material has mechanical properties close to those of a human body, and the bone material is free of inflammatory reaction and thrombotic reaction, can be degraded in the human body and is widely applied to various medical scenes. The invention further provides a preparation method of the novel skeleton material, and technical support is provided for industrial production of the skeleton material.
Owner:XIANGFU LABORATORY
A human malignant giant cell tumor of bone cell line and its use
The present application relates to the technical field of tumor biology, and specifically discloses a human malignant giant cell tumor of bone cell line and application thereof, the human malignant giant cell tumor of bone cell line is preserved on April 9, 2025, the preservation address is China Center for Type Culture Collection, located in Wuhan University in Wuhan, Hubei Province, and the preservation number is CCTCC NO:C202539.The human malignant giant cell tumor of bone cell line of the present application is from the tumor tissue after surgical resection of a Chinese malignant giant cell tumor of bone patient, and is suitable as cell material for developing malignant giant cell tumor of bone related immunotherapy, diagnosis and drug development.The cell line of the present application contains H3F3A G34W mutation, and has high sensitivity and specificity in the diagnosis of malignant giant cell tumor of bone.This cell line can be used as a tool cell for researching target drugs with H3F3A as a target, provides a cell model for Chinese malignant giant cell tumor of bone research, and provides an experimental platform for mechanism research of malignant giant cell tumor of bone.
Owner:THE SECOND AFFILIATED HOSPITAL OF NAVAL MEDICAL UNIVERSITY PLA
A method for preparing a bioceramic bone scaffold with gradient structure using 3DFP additive manufacturing
The application discloses a preparation method of a bioceramic bone scaffold with a gradient structure using 3DFP additive manufacturing; the method comprises the following steps: designing a biological gradient structure model; preparing a wire material containing nano-zirconium oxide, tricalcium phosphate, hydroxyapatite and silver oxide powder, mixing and preparing a slurry, and preparing a wire; adding the prepared wire into a printer, completing layer-by-layer printing of the gradient structure according to a slicing path, and obtaining a scaffold body; and heat treating, then cooling in a furnace to room temperature, thereby obtaining the bioceramic bone scaffold. The composition ratio of the wire material is optimized in a deep level, and the mechanical strength of the scaffold material is improved; meanwhile, the composition gradient and the structure gradient are designed, the cancellous bone with different components and structures is designed in the inner layer on the basis of guaranteeing the high strength, hardness and bending resistance of the compact bone, so that the scaffold and the tissue or cells can effectively interact, the adhesion, proliferation and differentiation of the bone cells are promoted, and the tissue repair and regeneration are facilitated.
Owner:SHANGHAI JIAOTONG UNIV
A skull flap resuscitation perfusion device
ActiveCN224268010UImprove survival rateImprove repair and cleaning efficiencyDead animal preservationFlap repairBone flap
This utility model discloses a cranial flap resuscitation and perfusion device, including a workbench with a platform plate fixedly connected to the top of the workbench; a perfusion mechanism is provided on the top of the platform plate, and a sealing component is provided inside the perfusion mechanism; wherein, the perfusion mechanism includes an insulated box fixedly installed on one side of the top of the platform plate, and an inner liner is embedded in the inner side of the insulated box, and a liquid addition pipe is fixedly connected between the top of the insulated box and the inner liner, thereby enabling precise control of the temperature, flow rate and pressure of the perfusion fluid, simulating the human physiological environment, providing good resuscitation conditions for the isolated cranial flap, effectively maintaining the activity of cranial flap bone cells, improving the survival rate of cranial flap after reimplantation, reducing the incidence of postoperative complications such as bone flap necrosis and infection, greatly improving the efficiency of cranial flap repair and cleaning, and reducing the workload of staff.
Owner:HENAN TISSUE CELL BANK CO LTD
Laser therapy device
1. Name of the product in this design: Laser Therapy Device. 2. Purpose of this design: This design is used for rehabilitation therapy and muscle and bone cell repair. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.
Owner:巫家伟 +1
Bone repair porous tissue engineering scaffold with electromagnetic response as well as preparation method and application thereof
PendingCN120459383AAdditive manufacturing apparatusBone implantCell-Extracellular MatrixOsseointegration
The invention discloses a bone repair porous tissue engineering scaffold with electromagnetic response as well as a preparation method and application thereof, and belongs to the field of medical materials. According to the invention, superparamagnetic nanoparticles are uniformly embedded into a high-molecular bionic porous scaffold, and a 3D printing technology is combined, so that the hierarchical porous scaffold with both macroscopic mechanical strength and microscopic biological activity is constructed. A porous structure is used for simulating an extracellular matrix of a bone, and the osseointegration efficiency is optimized. Meanwhile, in combination with the electromagnetic response characteristic of the stent, osteogenic differentiation of mesenchymal stem cells is dynamically regulated and induced and angiogenesis is accelerated through an external electromagnetic field, and a new-generation repair stent with mechanical adaptability, biological activity and intelligent responsiveness is provided for clinical refractory bone defects through interdisciplinary technology fusion; therefore, a'material-cell-microenvironment 'triple synergistic repair mechanism is realized.
Owner:PEKING UNION MEDICAL COLLEGE HOSPITAL
Active peptide for promoting osteoblast differentiation and its application
ActiveCN118146301Bclear ingredientsingredient safetyPeptide/protein ingredientsSkeletal disorderBone densityBiogenic peptide
The present invention discloses an active peptide that promotes osteocyte differentiation and its application, and relates to the technical field of biological peptides. The amino acid sequence of the active peptide that promotes osteocyte differentiation of the present invention is: Phe-Asp-Phe-Ser-Phe. The active peptide of the present invention has osteogenic activity and strong bone density regulating activity, and the active peptide of the present invention is a single purified active peptide with clear and safe ingredients, which is of great significance for the development of osteoporosis drugs, and solves the problem that the ingredients of the existing enzymatic hydrolysis products of collagen are unclear, which is not conducive to the later drug development and application.
Owner:HUACHENG PHARMA FACTORY GAUNGZHOU +1
A solution for digesting alveolar bone tissue and its use and method in the isolation of alveolar bone cells
The present application relates to the field of cell biology, in particular to a kind of alveolar bone tissue digestive juice and its use and method in alveolar bone cell separation, the alveolar bone tissue digestive juice includes basic culture medium, collagenase, DNA enzyme, BSA, EDTA, based on the total volume of alveolar bone tissue digestive juice, the final concentration of the collagenase is 200-400 U / ml, the final concentration of the DNA enzyme is 50-150 U / ml, the final concentration of the BSA is 0.1-2 mg / ml, and the final concentration of the EDTA is 0.5-1.5 mM.The separation method of the alveolar bone cell includes alveolar bone tissue in the alveolar bone tissue digestive juice is digested in several times, the alveolar bone tissue is grinded in the process, etc.Finally, alveolar bone cell is obtained.The alveolar bone tissue digestive juice and the separation method of alveolar bone cell of the present application realize the rapid and efficient extraction of alveolar bone tissue single cell suspension, and meet the high activity and high concentration required by single cell sequencing.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
A new type of medical bionic bone screw
The utility model provides a novel medical bionic bone screw, comprising a bionic bone screw body, wherein the bionic bone screw body comprises a base layer, a first functional layer and a second functional layer, wherein the first functional layer comprises a hydroxyapatite coating and a bioactive glass coating, and the second functional layer comprises a polypeptide self-assembled monolayer coating and a silver nanoparticle coating. By setting the first functional layer comprising the hydroxyapatite coating and the bioactive glass coating, wherein the hydroxyapatite coating is a mineral naturally existing in human bones and teeth, and is applied as a coating on the bone screw, the chemical and crystal structure of natural bones can be imitated, thereby improving the biocompatibility with human bones. The coating can promote the adhesion and proliferation of bone cells, accelerate the growth of bone tissue and the natural repair process of bones, and the bioactive glass coating can form a strong chemical bond with bone tissue to promote the growth of bone tissue.
Owner:JIANGSU GUOLI MEDICAL EQUIP
Split fusion device and method of manufacturing same
This invention provides a split-type fusion device and its manufacturing method. The split-type fusion device includes two independent fusion bodies configured to abut each other when implanted in the body. Each fusion body includes a conductive layer disposed on the side facing the other fusion body, and the fusion body is filled with a piezoelectric elastic material. The conductive layer is electrically connected to the elastic material. This split-type fusion device, by setting two independent, abuttable fusion bodies filled with piezoelectric elastic material and a conductive layer on the abutment surface of the fusion bodies, allows the microcurrent generated by the piezoelectric elastic material to be transmitted through the conductive layer, accelerating bone cell proliferation and differentiation and improving bone fusion efficiency. Simultaneously, the conductive layer guides bone cells to grow directionally at the abutment surface, promoting the gradual separation of the two fusion bodies and achieving adaptive intervertebral height adjustment in vivo. This allows height adjustment and bone fusion to be completed synchronously, solving the problem of the difficulty in simultaneously achieving both.
Owner:SUZHOU & SCI & TECH DEV
Carbon-based composite material skull connecting web plate and preparation method thereof
This invention discloses a carbon-based composite cranial connective mesh plate and its preparation method, belonging to the field of biomedical materials technology. The carbon-based composite material is machined into a cranial connective mesh plate matrix. After washing and drying, the matrix is first subjected to chemical vapor deposition of carbon and / or silicon carbide, followed by physical vapor deposition of a metal film. An electrochemical oxidation method is then used to convert the metal film into a metal oxide layer, thus obtaining the carbon-based composite cranial connective mesh plate. This connective mesh plate avoids the imaging artifacts and stress shielding defects present in metallic materials, and can enhance the adhesion, proliferation, and differentiation capabilities of bone cells, while also improving its biocompatibility, wear resistance, and mechanical properties.
Owner:HUNAN TANKANG BIOTECH CO LTD
Human malignant bone giant cytoma cell line and application thereof
The invention relates to the technical field of tumor biology, and particularly discloses a human malignant bone cytomegaloma cell line and application thereof.The human malignant bone cytomegaloma cell line is preserved on April 9, 2025, the preservation address is China Center for Type Culture Collection, the human malignant bone cytomegaloma cell line is located in Wuhan University, Wuhan, Hubei province, and the preservation number is CCTCC NO: C202539. The human malignant bone cytomegaloma cell line disclosed by the invention comes from tumor tissues of a Chinese malignant bone cytomegaloma patient after operation excision, and is suitable for being used as a cell material for research and development of malignant bone cytomegaloma related immunotherapy, diagnosis and medicine research and development. The cell line provided by the invention contains H3F3A G34W mutation, and has high sensitivity and specificity in diagnosis of malignant bone cytomegaloma. The cell line can be used as a tool cell for targeted drug research taking H3F3A as a target, a cell model is provided for research of malignant bone cytomegaloma of Chinese people, and an experimental platform is also provided for mechanism research of malignant bone cytomegaloma.
Owner:THE SECOND AFFILIATED HOSPITAL OF NAVAL MEDICAL UNIVERSITY PLA
Double-component ceramic surface hip prosthesis
The invention relates to a double-component hip prosthesis with a ceramic surface. The double-component ceramic surface hip prosthesis comprises an acetabulum outer cup and a surface ball head made of a ceramic material, wherein a femoral stem is arranged in an inner cavity of the surface ball head; the surface ball head is embedded in the acetabular outer cup and can rotate relative to the acetabular outer cup, the outer wall face of the acetabular outer cup and the inner wall face of the surface ball head are both covered with bone trabecula layers in a fusion covering mode through the coating preparation method, and the bone trabecula layers are in a net shape. Therefore, the problems that in the prior art, metal chippings are generated on a friction interface of a surface hip joint prosthesis, the prosthesis is prone to loosening, an outer cup is prone to deformation, and the effect that the outer cup induces bone cells to grow in is poor can be solved.
Owner:BEIJING CHUNLIZHENGDA MEDICAL INSTR
Preparation method of 3D printing porous degradable metal GBR membrane
ActiveCN119681268BAdditive manufacturing apparatusIncreasing energy efficiencyComputed tomographyPorous membrane
This invention relates to a method for preparing a 3D-printed porous biodegradable metal GBR membrane, belonging to the field of biomaterial additive manufacturing. The method includes the following steps: S1, performing a CT scan of the alveolar bone of the patient undergoing bone defect repair, and using reverse engineering technology to obtain a scanned prototype of the personalized GBR membrane; S2, selecting a lattice structure with node connections and symmetry as the basic filling unit for constructing the porous GBR membrane; S3, performing a single-cell adaptive filling design on the scanned prototype of the personalized GBR membrane to form a porous GBR membrane model; S4, using post-printing processing software to correct the mesh of the porous GBR membrane model; S5, using biodegradable biometal powder, and preparing the porous biodegradable metal GBR membrane through 3D printing technology. Providing a personalized GBR membrane allows for better adaptation to the patient's oral structure. The porous GBR membrane promotes bone cell migration and growth, accelerating the bone defect repair process.
Owner:SOUTH CHINA UNIV OF TECH +1
Demineralized bone paper
PendingUS20260144913A1Bioreactor/fermenter combinationsBiological substance pretreatmentsTissue GraftingAssay
Disclosed herein are three-dimensional bone tissue grafts produced from stacked demineralized bone paper. Also disclosed are methods for treating a subject using tissue grafts produced from the disclosed demineralized bone paper. Also disclosed are assay systems that involves culturing bone-promoting cells on the disclosed demineralized bone paper.
Owner:UNIV OF MASSACHUSETTS