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16 results about "Bone cell" patented technology
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Bone cell' Bone cells', which are found within the bone tissue, are responsible for the make-up of the skeleton of vertebrates. They are made up of different bone cells: there is the compact tissue which is the hard outer part of the bone, the cancellous tissue which is all the spongy tissue inside of the compact tissue, and the subchondral tissue which is the smooth tissue at the end of each bone."All About Bone." All About Bone. Ohio State University, n.d. Web. 19 Mar. 2013. Bone cells all work together inside of the bones to help keep up the skeletal system. The bone cells do many things for the skeletal system such as the development of new bones, the maintenance of bones, and the regulation of minerals in the body. Types There are four main categories of bone cells which include: lining cells, which protect the boneOursler, Merry J., and Teresita Bellido Bellido. "B>one Cells." ASBMR Educational Materials. ASBMR Educational Materials, 12 Sept. 2003. Web. 19 March 2013. Osteoclasts Osteoclasts are very large multinucleate cells that are responsible for the breakdown of bones. The breakdown of bone is very important in bone health because it allows for bone remodeling.
Morphological feature-based turned undyed bone tissue pathological image cell segmentation and cell nucleus identification method
The invention discloses a morphological feature-based cell segmentation and cell nucleus identification method for a turned unstained bone tissue pathological image. The method comprises the following steps of: 1, eliminating tool marks by adopting a tool mark elimination method combining local frequency domain analysis and directional suppression; 2, performing cell segmentation by using a K-means method, and performing morphological expansion and topological analysis on a segmented single cell image to identify a cell nucleus in the single cell image; step 3, calculating morphological characteristic indexes of each region; the method comprises the following steps: establishing a multi-dimensional Gaussian mixture model according to existing bone cell labeled sample information, performing outlier detection according to statistical data analysis, and removing results which do not conform to cell morphology; classifying different regions, and removing non-cell regions; by calculating morphological characteristic indexes of each region, different regions are distinguished according to the indexes, and cells are preliminarily screened. According to the method, high-precision cell segmentation and cell nucleus identification can be carried out on the cut undyed bone tissue pathological image.
Owner:SHANGHAI JIAOTONG UNIV
Dental implant
A dental implant comprises a base main body arranged in a dental implant main body and a guide block arranged at the bottom end of the dental implant main body, the dental implant main body is in threaded connection with the base main body, and the dental implant main body is fixedly connected with the guide block; the dental implant main body comprises a first end head and a vertical part, the first end head is fixedly connected with the vertical part, and a threaded groove is formed in the inner wall of the first end head. The dental implant has the beneficial effects that through the arrangement of the fixing mechanism, the contact area between the dental implant and an alveolar bone can be reduced during installation, so that the heat generated during installation is reduced, the problem of bone cell necrosis easily caused by over-high temperature is avoided, and meanwhile, after the dental implant is installed, the bone cell necrosis can be avoided. The friction force between the dental implant and the alveolar bone can be increased, so that the situation that the dental implant slightly moves in the alveolar bone and synostosis formed between the dental implant and the alveolar bone is damaged when the abutment is rotated is avoided.
Owner:SHANGHAI CHUANGSHIJI MEDICAL TECHNOLOGY CO LTD
Nanotextured laser surface treated aggregate
The utility model relates to a kind of nanostructure of laser surface treatment aggregate, wherein the surface of the aggregate is titanium metal, and at least one microchannel with titanium dioxide (TiO2) after cooling is formed by laser melting and sputtering to form molten titanium, at least one microchannel includes: at least one micropore, at least one guide channel, and at least one nano-wall formed at least one nano-bulge layer and at least one nano-wall. The following bone healing and antibacterial index effects and purposes are achieved: A. accelerate bone healing related protein deposition, B. accelerate bone cell attachment, C. induce neovascularization, D. accelerate early calcification and bone mineralization, E. improve nutrient exchange, F. stabilize surface bone structure, and G. resist plaque formation.
Owner:BIOMATE MEDICAL DEVICES TECH +1
A method for preparing and using strontium-doped magnesium-bioactive glass
The present application relates to the technical field of bioactive glass, in particular to a preparation method and application of strontium-magnesium-doped bioactive glass, on the basis of selecting suitable raw materials, the co-precipitation method is adopted, strontium element is doped, and magnesium oxide is compoundedly added, so that the prepared bioactive glass has regular properties, good dispersible spherical particles, faster and stronger hydroxyapatite formation capacity, faster ion release rate, and can release calcium, phosphorus and silicon ions in simulated body fluid, form more hydroxyapatite, promote the proliferation and stability of bone cells, and stimulate new bone formation. The strontium-magnesium-doped bioactive glass is used in cooperation with mineral trioxide aggregate (MTA), so that cell adhesion, expression of bioactive enzymes, activity of fibroblasts can be promoted, and the strontium-magnesium-doped bioactive glass can be applied to the repair of human bone and dental pulp tissue.
Owner:GUANGXI XINYE BIOLOGICAL TECH
Carbon-based composite material skull connecting screen plate and preparation method thereof
The invention discloses a carbon-based composite material skull connecting screen plate and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: machining a carbon-based composite material into a skull connecting screen substrate, washing and drying the substrate, firstly performing chemical vapor deposition on a carbon or / and silicon carbide substrate, then performing physical vapor deposition on a metal film layer, and converting the metal film layer into a metal oxide layer by adopting an electrochemical oxidation method, thereby obtaining the carbon-based composite material skull connecting screen. The connecting screen plate can avoid the defects of imaging artifacts and stress shielding existing in metal materials, can enhance the adhesion, proliferation and differentiation capacity of bone cells, and can improve the biocompatibility, wear resistance and mechanical property of the bone cells at the same time.
Owner:HUNAN TANKANG BIOTECH CO LTD
Nanostructure of laser surface-treated bone materials
The present invention provides a nanostructure of a laser surface-treated bone material. [Solution] The surface of the bone material is titanium metal 3, and molten titanium metal is formed by laser sputtering. After cooling, it has at least one microchannel 10 made of titanium dioxide (TiO2). The nanostructure of the bone material includes at least one micropore 12, at least one guide channel 16, at least one nanoprotrusion particle layer 111 formed by at least one nanowall 11, and at least one nanowall. The effects and purposes of improving bone healing and antibacterial indicators are achieved: A. accelerating the deposition of bone healing-related proteins; B. accelerating the attachment of bone cells; C. inducing neovascularization; D. accelerating early calcification and bone mineralization; E. improving the exchange of nutrients; F. stabilizing the surface bone structure; and G. inhibiting plaque formation.
Owner:BIOMATE MEDICAL DEVICES TECH +1
Design method of bionic bone scaffold based on TPMS
The application discloses a design method of a bionic bone support based on TPMS and belongs to the technical field of bionic bone supports. The application is based on G unit and D unit formulas, adjusts a bias function to generate G gradient unit and D homogeneous unit CAD models; uses a fusion function to fuse the G gradient unit and the D homogeneous unit CAD models to generate a GD radial fusion CAD model, adjusts the bias function of the G gradient unit by using an interpolation method to make the GD radial fusion CAD model reach a target average porosity; reduces the wall thickness of the GD radial fusion CAD model to form a GD radial fusion CAD model with wall thickness; then divides the GD radial fusion CAD model with wall thickness into a finite element simulation grid model and outputs an inp format simulation model file; imports the inp format simulation model file into HyperMesh software, repairs and divides the grid and exports an inp file format model. The porous support designed by the application considers different functional grading of natural bone structures and different cell morphological fusion, better meets the mechanical properties of a natural femur, and light weight design increases the specific surface area to provide more space for bone cell adhesion and growth.
Owner:KUNMING UNIV OF SCI & TECH
A human malignant giant cell tumor of bone cell line and its use
The present application relates to the technical field of tumor biology, and specifically discloses a human malignant giant cell tumor of bone cell line and application thereof, the human malignant giant cell tumor of bone cell line is preserved on April 9, 2025, the preservation address is China Center for Type Culture Collection, located in Wuhan University in Wuhan, Hubei Province, and the preservation number is CCTCC NO:C202539.The human malignant giant cell tumor of bone cell line of the present application is from the tumor tissue after surgical resection of a Chinese malignant giant cell tumor of bone patient, and is suitable as cell material for developing malignant giant cell tumor of bone related immunotherapy, diagnosis and drug development.The cell line of the present application contains H3F3A G34W mutation, and has high sensitivity and specificity in the diagnosis of malignant giant cell tumor of bone.This cell line can be used as a tool cell for researching target drugs with H3F3A as a target, provides a cell model for Chinese malignant giant cell tumor of bone research, and provides an experimental platform for mechanism research of malignant giant cell tumor of bone.
Owner:THE SECOND AFFILIATED HOSPITAL OF NAVAL MEDICAL UNIVERSITY PLA
A method for preparing a bioceramic bone scaffold with gradient structure using 3DFP additive manufacturing
The application discloses a preparation method of a bioceramic bone scaffold with a gradient structure using 3DFP additive manufacturing; the method comprises the following steps: designing a biological gradient structure model; preparing a wire material containing nano-zirconium oxide, tricalcium phosphate, hydroxyapatite and silver oxide powder, mixing and preparing a slurry, and preparing a wire; adding the prepared wire into a printer, completing layer-by-layer printing of the gradient structure according to a slicing path, and obtaining a scaffold body; and heat treating, then cooling in a furnace to room temperature, thereby obtaining the bioceramic bone scaffold. The composition ratio of the wire material is optimized in a deep level, and the mechanical strength of the scaffold material is improved; meanwhile, the composition gradient and the structure gradient are designed, the cancellous bone with different components and structures is designed in the inner layer on the basis of guaranteeing the high strength, hardness and bending resistance of the compact bone, so that the scaffold and the tissue or cells can effectively interact, the adhesion, proliferation and differentiation of the bone cells are promoted, and the tissue repair and regeneration are facilitated.
Owner:SHANGHAI JIAOTONG UNIV
A skull flap resuscitation perfusion device
ActiveCN224268010UImprove survival rateImprove repair and cleaning efficiencyDead animal preservationFlap repairBone flap
This utility model discloses a cranial flap resuscitation and perfusion device, including a workbench with a platform plate fixedly connected to the top of the workbench; a perfusion mechanism is provided on the top of the platform plate, and a sealing component is provided inside the perfusion mechanism; wherein, the perfusion mechanism includes an insulated box fixedly installed on one side of the top of the platform plate, and an inner liner is embedded in the inner side of the insulated box, and a liquid addition pipe is fixedly connected between the top of the insulated box and the inner liner, thereby enabling precise control of the temperature, flow rate and pressure of the perfusion fluid, simulating the human physiological environment, providing good resuscitation conditions for the isolated cranial flap, effectively maintaining the activity of cranial flap bone cells, improving the survival rate of cranial flap after reimplantation, reducing the incidence of postoperative complications such as bone flap necrosis and infection, greatly improving the efficiency of cranial flap repair and cleaning, and reducing the workload of staff.
Owner:HENAN TISSUE CELL BANK CO LTD
Laser therapy device
1. Name of the product in this design: Laser Therapy Device. 2. Purpose of this design: This design is used for rehabilitation therapy and muscle and bone cell repair. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.
Owner:巫家伟 +1
Split fusion device and method of manufacturing same
This invention provides a split-type fusion device and its manufacturing method. The split-type fusion device includes two independent fusion bodies configured to abut each other when implanted in the body. Each fusion body includes a conductive layer disposed on the side facing the other fusion body, and the fusion body is filled with a piezoelectric elastic material. The conductive layer is electrically connected to the elastic material. This split-type fusion device, by setting two independent, abuttable fusion bodies filled with piezoelectric elastic material and a conductive layer on the abutment surface of the fusion bodies, allows the microcurrent generated by the piezoelectric elastic material to be transmitted through the conductive layer, accelerating bone cell proliferation and differentiation and improving bone fusion efficiency. Simultaneously, the conductive layer guides bone cells to grow directionally at the abutment surface, promoting the gradual separation of the two fusion bodies and achieving adaptive intervertebral height adjustment in vivo. This allows height adjustment and bone fusion to be completed synchronously, solving the problem of the difficulty in simultaneously achieving both.
Owner:SUZHOU & SCI & TECH DEV
Carbon-based composite material skull connecting web plate and preparation method thereof
This invention discloses a carbon-based composite cranial connective mesh plate and its preparation method, belonging to the field of biomedical materials technology. The carbon-based composite material is machined into a cranial connective mesh plate matrix. After washing and drying, the matrix is first subjected to chemical vapor deposition of carbon and / or silicon carbide, followed by physical vapor deposition of a metal film. An electrochemical oxidation method is then used to convert the metal film into a metal oxide layer, thus obtaining the carbon-based composite cranial connective mesh plate. This connective mesh plate avoids the imaging artifacts and stress shielding defects present in metallic materials, and can enhance the adhesion, proliferation, and differentiation capabilities of bone cells, while also improving its biocompatibility, wear resistance, and mechanical properties.
Owner:HUNAN TANKANG BIOTECH CO LTD
Human malignant bone giant cytoma cell line and application thereof
The invention relates to the technical field of tumor biology, and particularly discloses a human malignant bone cytomegaloma cell line and application thereof.The human malignant bone cytomegaloma cell line is preserved on April 9, 2025, the preservation address is China Center for Type Culture Collection, the human malignant bone cytomegaloma cell line is located in Wuhan University, Wuhan, Hubei province, and the preservation number is CCTCC NO: C202539. The human malignant bone cytomegaloma cell line disclosed by the invention comes from tumor tissues of a Chinese malignant bone cytomegaloma patient after operation excision, and is suitable for being used as a cell material for research and development of malignant bone cytomegaloma related immunotherapy, diagnosis and medicine research and development. The cell line provided by the invention contains H3F3A G34W mutation, and has high sensitivity and specificity in diagnosis of malignant bone cytomegaloma. The cell line can be used as a tool cell for targeted drug research taking H3F3A as a target, a cell model is provided for research of malignant bone cytomegaloma of Chinese people, and an experimental platform is also provided for mechanism research of malignant bone cytomegaloma.
Owner:THE SECOND AFFILIATED HOSPITAL OF NAVAL MEDICAL UNIVERSITY PLA
Preparation method of 3D printing porous degradable metal GBR membrane
ActiveCN119681268BAdditive manufacturing apparatusIncreasing energy efficiencyComputed tomographyPorous membrane
This invention relates to a method for preparing a 3D-printed porous biodegradable metal GBR membrane, belonging to the field of biomaterial additive manufacturing. The method includes the following steps: S1, performing a CT scan of the alveolar bone of the patient undergoing bone defect repair, and using reverse engineering technology to obtain a scanned prototype of the personalized GBR membrane; S2, selecting a lattice structure with node connections and symmetry as the basic filling unit for constructing the porous GBR membrane; S3, performing a single-cell adaptive filling design on the scanned prototype of the personalized GBR membrane to form a porous GBR membrane model; S4, using post-printing processing software to correct the mesh of the porous GBR membrane model; S5, using biodegradable biometal powder, and preparing the porous biodegradable metal GBR membrane through 3D printing technology. Providing a personalized GBR membrane allows for better adaptation to the patient's oral structure. The porous GBR membrane promotes bone cell migration and growth, accelerating the bone defect repair process.
Owner:SOUTH CHINA UNIV OF TECH +1
Demineralized bone paper
PendingUS20260144913A1Bioreactor/fermenter combinationsBiological substance pretreatmentsTissue GraftingAssay
Disclosed herein are three-dimensional bone tissue grafts produced from stacked demineralized bone paper. Also disclosed are methods for treating a subject using tissue grafts produced from the disclosed demineralized bone paper. Also disclosed are assay systems that involves culturing bone-promoting cells on the disclosed demineralized bone paper.
Owner:UNIV OF MASSACHUSETTS