8 results about "Osteoblast adhesion" patented technology

The utility model provides a fibrous membrane for guiding periodontal tissue regeneration, and relates to the technical field of medical instruments. Preparing a PLGA double-layer fiber membrane loaded with drug-loaded sodium hyaluronate particles through the cooperative work of electrostatic spinning and electrostatic spraying; the sodium hyaluronate particles can greatly improve the loading rate of hydrophilic anti-inflammatory antibacterial and bone regeneration promoting medicines; a PLGA compact layer in the PLGA double-layer fiber membrane is loaded with first sodium hyaluronate particles loaded with anti-inflammatory and antibacterial drugs, and when the first sodium hyaluronate particles make contact with gingival tissue, cell adhesion and permeation can be hindered, and the anti-inflammatory and antibacterial effects can be achieved; a PLGA loose layer in the PLGA double-layer fiber membrane carries second sodium hyaluronate particles loaded with a bone regeneration promoting medicine, and the second sodium hyaluronate particles can promote osteoblast adhesion and facilitate dentale regeneration when making contact with bone tissue.

A high-strength porous metal implant material comprises a three-dimensional interconnected porous structure with a porosity of 55-90%, and two or more reinforcing elements distributed at the edge of the porous structure. The reinforcing elements are integrally formed and seamlessly bonded to each other and to the porous material. The reinforcing element structure of the porous metal implant material improves the material's mechanical strength. Its porous structure promotes bone tissue ingrowth into the porous metal's pores, facilitates osteoblast adhesion, differentiation, and growth, enhances the integration of the implant with bone, and achieves long-term biological fixation of the implant to human tissue. The thickness of the reinforcing elements, their positional distribution, or their volume percentage within the overall material can be adjusted according to the stress or mechanical performance requirements of the bone repair or bone defect site, thereby enabling the production of bone filling and implant materials that meet the different mechanical strength requirements of various locations.

The invention belongs to the technical field of antibacterial implant materials, and discloses an ultrasonic response titanium oxide antibacterial medical implant material as well as preparation and application thereof. The method comprises the following steps: 1) introducing titanium oxide seed crystals on the surface of a titanium-based substrate; and 2) putting the titanium-based matrix into which the titanium oxide seed crystals are introduced in the step 1) into a titanium precursor solution, regulating the reaction process through acid, and adding a surfactant for hydrothermal reaction to obtain a black titanium dioxide array material growing on the surface of the titanium-based matrix, namely the ultrasonic response titanium oxide antibacterial medical implant material. The method is simple, the prepared material can resist bacteria through ultrasonic response and has the characteristic of resisting bacterial infection for a long time, the nanorod array structure in the material is beneficial to osteoblast adhesion, proliferation and differentiation, and the osseointegration performance of the titanium-based material is improved. In addition, due to in-situ generation, the material disclosed by the invention is firmly combined with a titanium-based matrix and shows excellent coating stability. The material provided by the invention is used as a bone defect repair material.

The invention relates to a biphase calcium phosphate / hydroxyapatite bone substitute material and a preparation method thereof. The bone substitute material comprises a degradable calcium phosphate core layer, a porous hydroxyapatite precursor layer and a hydroxyapatite gradient layer, wherein the porous hydroxyapatite precursor layer is formed on the surface of the degradable calcium phosphate core layer in situ through a sol-gel method, and the hydroxyapatite gradient layer is formed through electro-deposition treatment and covers the porous hydroxyapatite precursor layer. According to the technical scheme, a layered mineralization structure with a porous hydroxyapatite precursor layer as a template is constructed, and a hydroxyapatite layer with a continuous gradient in the thickness direction is formed through segmented electro-deposition treatment, so that the obtained composite material realizes continuous transition from outside to inside in the aspects of porosity, grain size, crystallinity and Ca / P ratio. The structure of the biphase calcium phosphate / hydroxyapatite bone substitute material can remarkably improve the interface bonding strength, the ion exchange capacity and the biological activity, so that the osteoblast adhesion, proliferation and osteogenic differentiation capacities are improved, and the overall osteogenic performance is obviously superior to that of an existing material.

The application relates to the technical field of dental implants, in particular to a trans-zygomatic implant and a processing technology thereof, and the processing technology comprises variable-distance multi-stage sand blasting and acid etching surface treatment on an anchoring part with threads of the trans-zygomatic implant and electrochemical polishing surface treatment on an extension part without threads. The trans-zygomatic implant is treated by variable-distance multi-stage sand blasting combined with acid etching, so that a uniform micron-level rough base and a multi-stage micropore structure can be formed on the titanium surface, osteoblast adhesion and differentiation are facilitated, the early bone combination speed is accelerated, the combination strength is improved, the early implant loosening risk is reduced, the extension part of the trans-zygomatic implant is treated by electrochemical polishing, a smooth surface can be obtained, plaque adhesion and bacterial colonization are greatly reduced, the implant peri-implantitis risk is reduced, and soft tissue adhesion is promoted; the dual optimization of bone anchoring and tissue adhesion is realized, and the long-term function and health of the trans-zygomatic implant under complex stress are guaranteed.

The invention discloses a surface treatment method of a silicon nitride dental implant, which comprises the following steps: mixing ceramic powder with a sintering aid, and sintering at high temperature to obtain a compact silicon nitride ceramic base material; the base material is polished, and a dental implant precursor with the surface roughness Ra lower than 20 nm is obtained; removing a surface glass phase through selective etching of an acid-base compound, and exposing silicon nitride crystal grains; and finally, cleaning and drying to obtain the silicon nitride dental implant. The surface roughness Ra of the obtained silicon nitride dental implant is 40-100 nm, the contact angle is lower than 20 degrees, and the zeta potential absolute value is larger than 30 mV. The dental implant treated by the method disclosed by the invention can be used for remarkably promoting osteoblast adhesion, proliferation and differentiation while keeping high mechanical properties (three-point bending strength is more than or equal to 800 MPa, Vickers hardness is more than or equal to 1500 HV and fracture toughness is more than or equal to 7.0 MPa.m < 1 / 2 >), and is also suitable for implantation application in the orthopedics department.

This invention relates to the field of polyvinyl alcohol (PVA) materials technology, specifically disclosing a PVA-based composite material, its preparation method, and its applications. This invention utilizes femtosecond laser technology to surface-treat a titanium alloy matrix, creating a unique micro / nano hierarchical structure on the titanium alloy surface. This enhances the bonding strength between the gel and the titanium alloy matrix. Furthermore, by introducing an appropriate amount of copper ions into a PVA-based polymer with a specific structure, a bioactive surface promoting osteoblast adhesion and proliferation is constructed. 2+ The introduction of this compound not only improves the biocompatibility and antibacterial properties of the material, but also avoids cytotoxic reactions and protein adsorption induced by high concentrations of metal ions, thereby achieving stable and long-lasting antibacterial effects and promoting the directed differentiation of osteoblasts. This polyvinyl alcohol-based composite material is expected to bring more reliable and lasting therapeutic effects to the clinical treatment of bone diseases and implant repair, and has broad application prospects in the field of bone repair implant materials.

The application discloses a porous membrane material with an active healing function and a preparation method and application thereof, and belongs to the technical field of dental materials. The method of the application is characterized in that a solution A of polylactic acid, a solution B of polycaprolactone, a solution C of a surfactant and a dispersion liquid D of a carbon material are uniformly mixed, and the obtained mixed solution is cast on a bacterial cellulose membrane, and then cured into a film under the conditions of a temperature of 10-40 DEG C and a relative humidity of 40-95%, thereby obtaining the porous membrane material with the active healing function. The preparation method of the application can in-situ prepare the porous membrane material with asymmetric surface pores, internal communicating large pores and rich micropores on the bacterial cellulose membrane. When used as a guided bone regeneration barrier membrane, the porous membrane material can effectively block the growth of soft tissue cells into a bone defect area, maintain osteogenesis space, promote osteoblast adhesion and proliferation, has the active healing function, and is expected to efficiently promote bone tissue regeneration.