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Application of a titanium implant storage solution containing vitamin c
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A technology of vitamins and implants, applied in dental implants, dental prosthetics, dentistry, etc., can solve the problems of lack of targeted research on implant storage, and achieve the promotion of osteoblast adhesion, new bone formation, and good wettability and biocompatibility effects
Active Publication Date: 2022-01-25
NANJING MEDICAL UNIV +1
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Problems solved by technology
However, compared with the vigorous research on the surface modification of titanium implants, the targeted research on implant storage is quite scarce
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Embodiment 1
[0024] A liquid storage method for an implant containing vitamin C, the method comprising the following steps:
[0025] (1) Titanium sheet pretreatment: use SiC waterproof sandpaper (320 mesh, 600 mesh, 800 mesh, 1200 mesh, 1500 mesh) in the same direction to polish step by step until the surface has a metallic luster and the surface scratches are consistent. Ultrasonic cleaning with double distilled water, absolute ethanol and double distilled water for 15 min.
[0026] (2) Prepare vitamin C storage solution, dissolve vitamin powder in normal saline, and prepare 100mM and 10mM vitamin C solutions.
[0027] (3) Ultrasonically clean the titanium sheet in step 1 with double-distilled water and store it in the prepared vitamin C solution for 10 days in a sealed and dark place.
Embodiment 2
[0029] A liquid storage method for an implant containing vitamin C, the method comprising the following steps:
[0030] (1) Titanium sheet pretreatment: use SiC waterproof sandpaper (320 mesh, 600 mesh, 800 mesh, 1200 mesh, 1500 mesh) in the same direction to polish step by step until the surface has a metallic luster and the surface scratches are consistent. Then ultrasonically clean with double distilled water, absolute ethanol and double distilled water for 15 min.
[0031] (2) On the basis of step (1) Al(OH) 3 Sandblasting (pressure: 0.3MPa, particle size: 80 mesh, distance: 1.5cm, angle: 80 degrees, time: 15s), ultrasonic cleaning in acetone, 75vt.% ethanol and distilled water in sequence, drying; nitric acid, hydrofluoric acid The mixed solution is double distilled water according to the volume ratio: 0.22wt.% HF: 0.57wt.% HNO 3 =1000:2:4 room temperature treatment 10min, double distilled water ultrasonic 15min, drying; hydrochloric acid, sulfuric acid mixed acid is do...
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Abstract
The liquid storage method of the implant is to use SiC waterproof sandpaper to polish the titanium sheet step by step in the same direction until the surface has a metallic luster and the surface scratches are consistent, and then ultrasonically clean it with double-distilled water, absolute ethanol, and double-distilled water; The titanium sheet is sandblasted, then placed in acetone, ethanol, and distilled water for ultrasonic cleaning and drying; nitric acid, hydrofluoric acid mixed solution is treated at room temperature, double distilled water is ultrasonically dried; hydrochloric acid and sulfuric acid mixed acid are treated in a water bath at 80°C until foaming , double-distilled water ultrasonic cleaning; dissolving vitamin C in normal saline; the obtained titanium sheet was sealed and protected from light and stored in the prepared vitamin C solution after ultrasonic cleaning with double-distilled water. In the liquid storage method of the implant provided by the present invention, the titanium surface can be activated in advance by the storage solution, which has the effect of promoting the adhesion, proliferation and differentiation of osteoblasts, and better promotes new bone formation. At the same time, it has good wettability and biocompatibility, and has a wide range of application values.
Description
technical field [0001] The invention belongs to the field of implant storage, and in particular relates to the application of a titanium implant storage solution containing vitamin C. Background technique [0002] Commonly used clinical oral implant systems such as Straumann, 3i, and Nobel Biocare are all pure titanium implants. These systems use large-particle sandblasting-acid etching (SLA), double acid etching, and micro-arc oxidation to construct surface micron-level roughness to promote the adhesion, proliferation, and differentiation of osteoblasts, and increase the bond between implants and bone. Contact area and mechanical mating force. However, pure titanium itself lacks osteoinductive properties and cannot form chemical bonds with surrounding bone tissue, and it takes a long time to form strong osseointegration after implantation. In view of this, scholars at home and abroad have conducted a lot of research on the surface modification and activation of titanium i...
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