29 results about "New Bone Formations" patented technology

The application discloses a jaw bone defect negative pressure repair body with a flushing function and a preserved periosteum, which comprises a base body, the base body is a titanium alloy net structure formed by 3D printing, two ends of the base body are adapted to be attached to bone broken ends, and an outer surface of the base body is adapted to be contacted with jaw bone periosteum, the base body is internally provided with a negative pressure suction pipeline penetrating through the base body, an outer pipe opening of the negative pressure suction pipeline is connectable to a negative pressure suction device, a pipe wall of the negative pressure suction pipeline is distributed with through holes formed by the titanium alloy net structure, and a reserved flushing pipeline is arranged around an outer periphery of the negative pressure suction pipeline, and the reserved flushing pipeline is distributed with flushing holes around the outer periphery. The repair body has the following functions: promoting growth and differentiation of osteoblasts on the surface of the bone broken ends and the periosteum, and promoting new bone formation; and being capable of discharging tissue exudates and the like out of the body.

An implant device configured to be at least partially in contact with bone on implantation has an improved osteoinductive feature to enhance new bone formation. The implant device has one or more bone growth surfaces extending from a structurally solid feature of the implant device. The one or more bone growth surfaces are configured to mimic adult trabecular bone by having trenches, grooves or surface recesses or prominences exhibiting numerous structural elements or walls not perpendicular to the surface that are non-coplanar or arched extending 20 to 500 microns in depth having an increasing inclination from the surface extending inwardly and not parallel to opposing or adjacent walls forming a random or non-random network. The one or more bone growth surfaces configured to mimic trabecular bone have discernable nano features on the structural elements or walls exhibiting nano scale features of less than 200 nano meters within the network.

The invention discloses an alpha-ketoglutaric acid functionalized hydrogel and application thereof in maxillofacial bone defect repair, and belongs to the technical field of biomedical materials. The hydrogel is constructed by crosslinking four-arm polyethylene glycol-sulfydryl and alpha-ketoglutaric acid through a Fe < 3 + > coordination bond. The hydrogel prepared by the invention has good mechanical properties, self-healing ability and inflammatory microenvironment responsive drug release characteristics, and can synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells, induce M2 polarization of macrophages and remove active oxygen, thereby optimizing a bone regeneration microenvironment. In-vivo experiments prove that the hydrogel can significantly promote the formation of new bones of a mouse jaw defect model. The invention provides a novel and efficient material solution for regeneration and repair of maxillofacial bone defects.

The invention belongs to the technical field of biomedical materials, and discloses a bone tissue repair material for promoting vascularization and new bone generation and a preparation method thereof. The bone tissue repair material is composed of a decalcified bone matrix and a degradable biological source gel material. The repair material has a loose porous three-dimensional structure similar to that of natural cancellous bone, and the temperature-sensitive gel material filled in the pore structure of the repair material can form gel in situ in vivo and is attached to pores of a decalcified bone matrix, so that cell migration, adhesion and proliferation can be promoted, the degradation rate of gel in vivo can be reduced, and the repair material has a good application prospect. The continuous release of the pro-angiogenesis factor is ensured. Good biocompatibility is achieved, and cytotoxicity and immunogenicity are avoided; meanwhile, in the slow degradation process, angiogenesis promoting factors are continuously released for a long time, and angiogenesis and new bone generation are promoted. Therefore, the implanted biological scaffold prepared from the bone tissue repair material has excellent bone repair and regeneration promotion capability and wide application prospect.

The unilateral alveolar split newborn maxilla orthopedic device comprises a palate plate and a retention stabilizing accessory, buccal side stretching accessories are connected to the outer portions of the left side edge and the right side edge of the palate plate, the material of the buccal side stretching accessories is softer than that of the palate plate, and the buccal side stretching accessories and the palate plate are of an integrated structure; the cheek side stretching accessory upwards protrudes out of the outer parts of the left and right side edges of the palate plate. The cheek side distraction accessory can generate an outward distraction effect on gingival tissues at the maxillary vestibular sulcus part, promote formation of new bones at the cheek side of maxillary alveolar bones, realize accurate quantitative controllable movement of alveolar bone sections, particularly effectively increase the transverse width, improve the comfort of the distraction effect due to the design of the edge buffer soft lining, and improve the safety of the distraction of the maxillary alveolar bones. The treatment effect is improved.

The present application relates to the technical field of bioactive glass, in particular to a preparation method and application of strontium-magnesium-doped bioactive glass, on the basis of selecting suitable raw materials, the co-precipitation method is adopted, strontium element is doped, and magnesium oxide is compoundedly added, so that the prepared bioactive glass has regular properties, good dispersible spherical particles, faster and stronger hydroxyapatite formation capacity, faster ion release rate, and can release calcium, phosphorus and silicon ions in simulated body fluid, form more hydroxyapatite, promote the proliferation and stability of bone cells, and stimulate new bone formation. The strontium-magnesium-doped bioactive glass is used in cooperation with mineral trioxide aggregate (MTA), so that cell adhesion, expression of bioactive enzymes, activity of fibroblasts can be promoted, and the strontium-magnesium-doped bioactive glass can be applied to the repair of human bone and dental pulp tissue.

The present application belongs to the technical field of hydrogel materials, and particularly relates to a composite hydrogel for regulating energy metabolism and a preparation method and application thereof. The preparation raw material of the composite hydrogel for regulating energy metabolism comprises creatine modified double bond hydroxybutyl chitosan, hydroxyapatite, curcumin, an initiator and a solvent. CHBC provides energy metabolism support at the cell level, is conducive to the proliferation and differentiation of osteogenesis-related cells; HA provides an inorganic environment similar to bone mineralization, and plays a bone conduction and bone induction role; Cur regulates inflammatory response and improves oxidative stress state, and optimizes the repair microenvironment. Through synergy in different aspects such as energy metabolism support, structure mineralization and microenvironment regulation, the regulation of the energy metabolism state of cells in the bone repair area is realized, which is conducive to meeting the high energy requirement of osteoblasts in the repair process, and can promote new bone formation and improve the inflammatory and oxidative stress microenvironment of the injury area, and provides more favorable repair conditions for bone tissue regeneration.

The application discloses a kind of composite material based on engineering spirulina, its preparation method and application, the composite material includes hydrogel matrix and the engineering spirulina carrier dispersed in the hydrogel matrix;Wherein, the surface of spirulina is loaded with polyethyleneimine-coated Fe3O4 Nanoparticles, obtain the engineering spirulina carrier, and the engineering spirulina high expression arginine.One aspect, the present application is metabolically restructured to spirulina, so that its intracellular L-arginine content is significantly improved, L-arginine can simultaneously improve vascular function through iNOS path, and through Arg-1 path, promote macrophages to repair type M2 polarization and tissue repair, from metabolic root to intervene the core obstacle of bone defect;On the other hand, spirulina is surface modified, can effectively activate osteogenesis-related gene expression, drive new bone formation.By the double modification of L-arginine enrichment and Fe3O4 Nanoparticles loading to spirulina, obtain the composite material of synergistic regulation anti-inflammatory, pro-angiogenic and pro-osteogenic, accurately match the demand of complex pathological microenvironment of bone defect, to effectively treat bone defect, especially drug-related jaw osteonecrosis.

The invention provides a preparation method of an anti-inflammatory bone repair material for promoting angiogenesis, which comprises the following steps: adding amorphous calcium magnesium phosphate powder into a polylactic acid solution, carrying out ultrasonic treatment to uniformly disperse the amorphous calcium magnesium phosphate powder, and carrying out vacuum freeze drying to obtain the anti-inflammatory bone repair material. The mass ratio of the amorphous calcium magnesium phosphate powder to the polylactic acid is (1: 9)-(1: 1). Amorphous calcium magnesium phosphate is added into polylactic acid, so that a large amount of calcium magnesium phosphorus can be released after implantation, bone defect stem cell osteogenic differentiation and angiogenesis are promoted, and the biocompatibility of polylactic acid is improved. The addition of inorganic matters can accelerate the degradation rate of polylactic acid, and prevent the bone repair material from occupying for a long time to affect the generation of new bones. Meanwhile, the amorphous calcium magnesium phosphate can neutralize an acid environment generated by degradation of polylactic acid, and the inflammatory response of the defect part is relieved.

The application discloses a PLGA microsphere-PCL / GelMA composite scaffold based on nerve growth factor (NGF) sustained release and a preparation method and application thereof. The composite scaffold is constructed by embedding the NGF-loaded PLGA microsphere into the PCL framework and the GelMA hydrogel matrix, and a three-phase composite system with mechanical support, sustained release of biological factors and cell adhesion function is constructed. In vitro experiments show that the NGF-loaded composite scaffold significantly promotes the osteogenic differentiation of dental pulp stem cells, and the alkaline phosphatase activity is improved, the formation of mineralized nodules is increased, and the expression of osteogenesis-related genes RUNX2 , ALPL , COL1A1 and BGLAP is up-regulated. When applied to a rat skull critical defect model in vivo, the composite scaffold significantly promotes new bone formation and vascular nerve regeneration. Mechanism research shows that it realizes the regulation of osteogenesis and bone resorption by activating the PI3K / AKT signaling pathway. The composite scaffold is suitable for the repair of complex bone defects in the region rich in nerves and blood vessels, and has good clinical application prospect.

This invention belongs to the field of biomaterials technology, specifically relating to a bioactive scaffold, its preparation method, and its applications. This invention incorporates functionalized mesoporous silica nanoparticles loaded with aminoguanidine into the skin secretions of the giant salamander and polycaprolactone electrospun fibers to construct a bioactive composite scaffold (SPMA). This scaffold enables the sustained release of AG and osteogenic factors, effectively inhibiting free radical generation, AGEs toxicity, and inflammatory responses. Furthermore, it significantly improves the survival rate, osteogenic differentiation, and mineralization capacity of bone marrow mesenchymal stem cells in a high-glucose microenvironment. In vivo experiments further demonstrate that in a streptozotocin-induced diabetic mouse model of skull defects, the SPMA scaffold can alleviate local inflammation, promote angiogenesis, and significantly accelerate new bone formation and defect repair.

The application discloses a 3D printing high-strength supramolecular hydrogel and application thereof in bone defect repair. The high-strength supramolecular hydrogel is formed by hydrogen bond, ion interaction and hydrophobic association non-covalent cross-linking of a positively charged high-molecular polymer, a negatively charged functional monomer and a photoinitiator, and has a dynamic network structure. The hydrogel has a structure similar to an extracellular matrix, has self-healing, viscoelasticity and dynamics, and is beneficial to cell adhesion, proliferation, migration and differentiation. The hydrogel has superfast gelation, realizes second-level gelation solidification, and can accurately 3D print a microporous structure due to triple forces of strong hydrogen bond, electrostatic interaction and hydrophobic interaction. The hydrogel has good biodegradability, and the degradation rate can be designed by adjusting ingredients and cross-linking density, so that the degradation rate is matched with the speed of new bone formation, and finally, the scaffold material is completely replaced by new bone tissue.

The invention discloses application of PD-L1 positive mesenchymal stem cells in preparation of a medicine for inhibiting pathological osteogenesis, and belongs to the technical field of biological medicine. The medicine for inhibiting pathological osteogenesis is a medicine for preventing and / or treating diseases characterized by pathological new bone formation; the preparation method of the PD-L1 positive mesenchymal stem cells comprises the following steps: (1) providing a mesenchymal stem cell group to be screened; (2) detecting the PD-L1 expression level of each cell in the mesenchymal stem cell population to be screened; and (3) screening and enriching the PD-L1 high-expression mesenchymal stem cells according to the detection result of the step (2) to obtain the PD-L1 positive mesenchymal stem cells. The PD-L1 positive mesenchymal stem cell has a remarkable effect on inhibiting pathological osteogenesis, is a brand new treatment way, and has huge clinical value and market potential.

The invention provides an artificial skull restoration and relates to the technical field of biomedical materials, the artificial skull restoration comprises an inner layer, a middle layer and an outer layer which are sequentially connected from bottom to top, the inner layer is a compact structure layer, the middle layer comprises a compact frame structure and a porous loose structure, and the outer layer is a loose structure layer; the inner layer, the middle layer and the outer layer are all made of a first material or hydroxyapatite, and the first material is composed of polycaprolactone and beta-tricalcium phosphate. The artificial skull repair body provided by the invention not only has better biocompatibility and better mechanical property, but also has better degradation speed and new bone formation speed matching property, and can better promote skull tissue repair and regeneration.

The application provides a near-infrared response magnesium-releasing and antioxidant double-layer microneedle and a preparation method and application thereof. The double-layer microneedle comprises a needle tip layer and a backing layer, the needle tip layer contains MoS2@PDA@Mg 2+ The application discloses a composite particle, which is composed of molybdenum disulfide nanosheets, surface-coated polydopamine and coordination-loaded magnesium ions. The preparation method comprises the following steps: one-step reaction of molybdenum disulfide, dopamine and magnesium salt to obtain the composite particle, and then preparation of the composite particle into a needle tip layer precursor solution together with GelMA, PVA and the like, and two-step light cross-linking molding with a backing layer precursor solution. The double-layer microneedle can rapidly release magnesium ions under near-infrared irradiation, the release amount is 4.6 times that of a non-irradiation group, can significantly scavenge DPPH, ABTS and other free radicals, can relieve cell oxidative stress induced by lipopolysaccharide, and can effectively promote new bone formation and trabecular reconstruction in a rat tooth socket model. The application realizes the synergistic effect of light-controlled magnesium release and antioxidant, and is suitable for the fields of neural microenvironment reconstruction and bone regeneration.

The application discloses a histopathological evaluation device for the healing degree of bone injury, and relates to the technical field of medical devices, pharmacodynamics and pathological diagnosis. The device comprises a microscope configured to capture an image of a stained bone tissue section; an image processing unit connected to the microscope and configured to obtain semi-quantitative histological measurement results and microscopic bone histomorphometry measurement results based on the image of the stained bone tissue section; the semi-quantitative histological measurement results comprise the state of callus bridging and fracture line, the composition and maturity of callus, new bone formation activity and bone remodeling and structure recovery state; the microscopic bone histomorphometry measurement results comprise the bone volume fraction and the proportion of osteoid surface; and a host computer connected to the image processing unit and configured to generate the bone injury healing condition according to the two kinds of measurement results. The application combines semi-quantitative histological measurement and microscopic bone histomorphometry measurement, and can provide an objective and quantifiable statistical device and method for the healing effect of bone injury.

The application relates to a preparation method and application of a bionic scaffold with bone repair and anti-osteosarcoma functions, and the specific steps are as follows: firstly, polydopamine nanoparticles are added into a curcumin ethanol solution, room temperature stirring reaction is carried out, and a polydopamine nanoparticle solution loaded with curcumin is obtained; secondly, freeze-dried silk fibroin is dissolved in hexafluoroisopropanol to form a silk fibroin solution, acetone is added to crosslink the solution into a gel, ammonium bicarbonate is added, hydroxyapatite nanoparticles are added, and mixing is uniformly carried out, and a porous fiber scaffold is synthesized through supercritical CO2 assisted phase separation; finally, the porous fiber scaffold is added into the polydopamine nanoparticle solution loaded with curcumin, room temperature stirring reaction is carried out, and then freeze-drying is carried out, so that the silk fibroin scaffold is obtained. The silk fibroin scaffold provided by the application has the anti-osteosarcoma function, can simulate the composition and structure of bone and induce new bone formation, can simultaneously meet the purposes of treating bone tumors and repairing bone defects, and has important clinical value and scientific significance.

The implant processing method disclosed in this application includes the following steps: centrifuging blood from a blood collection tube to obtain liquid autologous platelet aggregate, extracting liquid autologous concentrated growth factor from it, and injecting the liquid autologous concentrated growth factor into a liquid autologous concentrated growth factor container; placing an untreated implant into the liquid autologous concentrated growth factor container to immerse it in the liquid autologous concentrated growth factor; and centrifuging the liquid autologous concentrated growth factor and the untreated implant to obtain an implant with its surface covered by the patient's autologous concentrated growth factor, which serves as a surface-treated implant to be implanted in the patient's oral cavity. This application can provide personalized implant processing solutions based on individual patient characteristics, effectively enhancing the integration ability of the implant with bone tissue, promoting new bone formation, and thus improving the implantation outcome.

The invention discloses a 3D printing high-strength supramolecular hydrogel and application of the 3D printing high-strength supramolecular hydrogel in bone defect repair. The high-strength supramolecular hydrogel is of a dynamic network structure formed by a high-molecular polymer with positive charges, a functional monomer with negative charges and a photoinitiator through hydrogen bonds, ionic interaction and hydrophobic association non-covalent crosslinking. The hydrogel disclosed by the invention has a structure similar to an extracellular matrix, has self-healing property, viscoelasticity and dynamic property, and is beneficial to adhesion, proliferation, migration and differentiation of cells; the hydrogel disclosed by the invention has an ultra-fast gelling property, second-level gelling curing is realized, and a microporous structure can be accurately printed in a 3D manner due to triple acting forces of strong hydrogen bonds, electrostatic interaction and hydrophobic interaction; the hydrogel has good biodegradability, and the degradation rate of the hydrogel can be designed by adjusting components and crosslinking density, so that the degradation rate of the hydrogel is matched with the speed of new bone formation, and finally, a scaffold material is completely replaced by new bone tissue.

This invention belongs to the field of materials technology, specifically relating to a biomedical nanocrystalline Ti-Mg alloy coating with a micro / nano porous structure, its preparation method, and its applications. This invention constructs a nanocrystalline Ti-Mg alloy coating with a micro / nano porous structure on the surface of pure titanium or titanium alloys. Specifically, its interior contains micron-sized macropores, while its pore walls contain numerous submicron to nano-sized micropores. The framework material is nanocrystalline, thereby achieving a synergistic enhancement of the bioactivity and adjustment of the elastic modulus of the Ti-Mg alloy through porous structures of different scales. Simultaneously, the nanocrystalline structure strengthens the mechanical properties of the porous coating. Ti acts as the framework, providing mechanical support, while Mg serves as the bioactive and micro / nano-porous material. When the Ti-Mg composite material is implanted into the human body, Mg gradually degrades, which can improve the material's bioactivity (inducing new bone formation).

The invention discloses a composition for preventing and / or treating osteoporosis and application thereof, and relates to the technical field of biological medicine. The composition comprises gnetum alcohol and quercetin in a mass ratio of 1: (1-15). According to the composition disclosed by the invention, the gnetum alcohol blocks an NLRP3 / Caspase1 / GSDMD channel in a targeted manner, osteoblast inflammatory pyroptosis is accurately inhibited, and the inflammatory microenvironment of an osteoporosis region is improved from the source; the quercetin is capable of efficiently removing oxidative stress products, reducing cascade injury, directionally promoting osteoblast proliferation and differentiation and improving local bone regeneration capacity; the two components form a complementary synergistic effect, so that the pyroptosis-mediated pathological source is cut off, the injury progress is intervened, the bone repair microenvironment is synchronously improved, the new bone formation is promoted, and the limitation of single target treatment is broken through, and the curative effect is remarkably superior to that of single medication when the medicine is used for preventing and / or treating osteoporosis.

The scheme discloses the field of biomedical materials and bone tissue engineering technology, and discloses a composite drug-loaded hydrogel and a preparation method and application thereof.The composite drug-loaded hydrogel comprises a self-assembled peptide hydrogel base, hollow mesoporous dopamine nanoparticles and simvastatin, the simvastatin is loaded in the hollow mesoporous structure of the hollow mesoporous dopamine nanoparticles to form SIM@H-MPDA drug-loaded nanoparticles, and the drug-loaded nanoparticles are stably dispersed in the three-dimensional network structure of RADA16-I.The preparation method of the composite drug-loaded hydrogel is also disclosed, and the preparation method comprises H-MPDA preparation, SIM@H-MPDA drug-loaded nanoparticle preparation and composite hydrogel assembly.The composite drug-loaded hydrogel has good injectability and in-situ gelation, can realize smooth and slow release of simvastatin, significantly promotes osteogenic differentiation and new bone formation, effectively repairs non-infectious bone defects, and has no adverse effects on main organs of the body.

The invention belongs to the field of biomedical polymer materials, and discloses a preparation method and application of an epitope imprinting bionic receptor for self-recruitment of endogenous osteogenic growth peptide. According to the invention, from the angle of collection of endogenous growth factors, the OGP is taken as a target molecule, the epitope imprinting polymer nanoparticles MIP with specific recognition capability are prepared by adopting an epitope imprinting technology, and specific capture of the endogenous OGP is realized. Further, according to the invention, the MIP is introduced into a polyethylene glycol PEG hydrogel system, and the epitope imprinting bionic receptor MIP (at) PEG capable of collecting endogenous osteogenic factors is prepared. Directional capture and slow release of OGP and activation of local osteogenesis signals are realized in vivo, and formation of new bones in a bone defect area is remarkably promoted. The invention provides a new thought and experimental basis for developing a novel tissue engineering scaffold based on endogenous growth factor recruitment, and has important clinical application prospects.

The invention provides a composite bone wax material as well as a preparation method and application thereof, and relates to the technical field of medical filling materials. The composite bone wax material provided by the invention is prepared from the following components in parts by mass: 1 to 10 parts of magnesium oxide, 1 to 10 parts of monopotassium phosphate, 1 to 5 parts of pregelatinized starch and 1 to 10 parts of polyethylene glycol, the mass ratio of the magnesium oxide to the monopotassium phosphate is (1-5): 1. In the composite bone wax material disclosed by the invention, magnesium oxide and monopotassium phosphate can react in a body fluid environment to realize rapid self-curing, so that the adhesion capability is favorably improved; by limiting the mass ratio of magnesium oxide to monopotassium phosphate, an alkaline environment can be formed, and formation of new bones can be induced; the pre-gelatinized starch provides thickening and gelling effects, and polyethylene glycol is used as a reaction medium to endow flexibility, so that the composite bone wax material can show better adhesion capacity in a continuous bleeding environment.

The invention provides a bone tissue engineering scaffold with magnesium content and modulus double gradients as well as a preparation method and application of the bone tissue engineering scaffold. The scaffold is formed by compounding a 3D printing inorganic scaffold composed of tricalcium phosphate / white calcomanite (TCP / WH) and active fiber reinforced matrix metalloproteinase (MMP) response hydrogel, and the hydrogel is poured into the inorganic scaffold to form double gradients of magnesium content and rigidity. The composite scaffold is particularly suitable for bone regeneration and repair through an in-cartilage osteogenesis mechanism, and cells can be gradually migrated to the active fibers from the hydrogel and then migrated to the inorganic scaffold under the traction of magnesium ion concentration and matrix rigidity, so that cell proliferation, chondrogenic differentiation, vascularization and new bone formation are promoted. The preparation method comprises the steps of 3D printing of the inorganic scaffold, preparation of the active fiber reinforced MMP response hydrogel, perfusion compounding of the active fiber reinforced MMP response hydrogel and the like. The composite scaffold material system has potential application value in the field of bone regeneration and repair.

The invention provides a multi-layer structure skull repair scaffold and a preparation method and a preparation process optimization method thereof, and relates to the technical field of skull repair scaffolds.The preparation method comprises the steps that CT and nuclear magnetic resonance scanning are carried out to obtain a defective skull tissue three-dimensional structure model; constructing a multi-layer structure skull repair scaffold structure reference model, wherein the multi-layer structure skull repair scaffold structure reference model comprises an external metal supporting layer, an internal biological ceramic degradation regeneration layer and a middle transition interface layer; the topological optimization is combined with extrusion simulation, printing simulation and sintering simulation for joint optimization; 3D printing slurry is prepared by adopting an extrusion 3D printing technology for printing to obtain a skull repair stent printing body with a multi-layer structure; and performing vacuum drying, vacuum sintering and cooling to obtain the skull repair stent with the multi-layer structure. Two materials of metal and ceramic are combined, and the outer-layer metal frame provides initial strength, rigidity and reliable fixing capacity required by an operation; the porous degradable biological ceramic on the inner layer creates a microenvironment beneficial to the generation of new bones, and finally the biodegradation of the scaffold and the in-situ regeneration of bone tissues are realized.

The application provides a kind of polypeptide and its application in bone defect repair, belong to polypeptide technical field.The application is based on the functional domain of TGF-beta 3 factor, designs 10 derived peptides, only selects one derived peptide with bone inductive property, the derived peptide is composed of 21 amino acid residues;The polypeptide can not only induce murine bone marrow mesenchymal stem cells to produce mineralization nodule in vitro, but also can induce new bone formation in rat skull extreme bone defect model (in vivo) and rat intramuscular (heterotopic ossification model), and the osteogenic induction efficiency is equivalent to BMP-2.Summing up, the polypeptide provided by the application has bone inductive property, and has great application prospect in bone defect repair.

The invention discloses an application of 6-shogaol in preparation of a medicine for promoting skeletal muscle regeneration and / or repair. The 6-shogaol can activate stationary-stage muscle satellite cells, promote myoblast differentiation and myotube fusion, guide damaged broken end new muscle fiber connection and realize structure repair. Meanwhile, 6-shogaol can inhibit excessive deposition of collagen, reduce scar formation and promote functional regeneration. In the fracture accompanied with muscle injury, the bone healing quality is synergistically enhanced by improving the soft tissue environment and vascularization, new bone formation is increased, and the problem of bone nonunion caused by muscle injury is solved. In a word, the 6-shogaol can solve the pain point that the physical injury of the skeletal muscle is difficult to heal through the dual mechanisms of promoting muscle regeneration and resisting fibrosis, and cooperatively promotes the accompanying bone injury repair. The application is different from conventional osteoporosis treatment or disuse atrophy treatment, and has definite clinical pertinence and application value.

1. The name of the design product: animal stretching device (special for distraction osteogenesis). 2. The use of the design product: used for installing on the bone cutting site of the lower jaw, femur and other bones of animals such as mice, rats, rabbits, etc., aligning and fixing the two bone cutting ends, and promoting large-scale new bone formation through periodic stretching. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.