5745results about How to "Promote proliferation" patented technology

The invention discloses an organic cultivation medium and an application method thereof. The organic cultivation medium is formed by fermenting a mixture comprising organic wastes (comprising straws, animal manures and organic garbage), sludge soil (urban sludge and substrate sludge of rivers and lakes) and composite soil microorganism preparations. The organic cultivation medium can be applied to plant and crop planting, and can be mixed with microelements, water-retaining agents and root-growth accelerants according to proportions in accordance with the nutrition requirement characteristics of plants and crops to form organic soil with common soil, and then the organic soil can be arranged in a manual anti-leakage cultivation slot or a specific container cultivation system to cultivate crops, vegetables and fruits, flowers or Chinese herbal medicine plants, etc.

A wound treatment device comprises a wound surface contacting plug (10) and a cover (24) for covering the wound surface (22) and the plug (10), wherein said plug (10) consists of a flat textile isolating material comprising at least one first surface layer (12), one second surface layer (14) and one intermediate space (18) arranged between said surface layers (12, 14). At least the first surface layer (12) is provided with a biocompatible surface and a structure which enables a liquid to pass and prevents a wound tissue from growing in said structure. The intermediate space (18) is provided with isolating threads (16) elastically holding the first surface layer (12) and the second surface layer at a certain distance from each other.

The present inventors studied the effects of inhibiting the IL-6 signaling pathway on muscle cell growth. As a result, they discovered that, administering an IL-6 inhibitor can promote the adhesion, proliferation, and differentiation of satellite cells and therefore muscle regeneration.

The present invention relates to a biocompatible, three-dimensional scaffold useful to grow cells and to regenerate or repair tissue in predetermined orientations. The scaffold is particularly useful for regeneration and repair of cardiac tissue. The scaffold contains layers of alternating A-strips and S-strips, wherein the A-strips within each layer are aligned parallel to each other and preferentially promote cellular attachment over attachment to the S-strips. Methods of producing and implanting the scaffold are also provided.

A wound treatment device comprises a wound surface contacting plug and a cover for covering the wound surface and the plug, wherein said plug consists of a flat textile isolating material comprising at least one first surface layer, one second surface layer and one intermediate space arranged between said surface layers. At least the first surface layer is provided with a biocompatible surface and a structure which enables a liquid to pass and prevents a wound tissue from growing in said structure. The intermediate space is provided with isolating threads elastically holding the first surface layer and the second surface layer at a certain distance from each other.

The invention relates to a method to take kitchen organic waste recycling process by compounding bacterium that includes the following steps: collecting the organic waste, adding water content adjusting material, taking high temperature fermenting process, taking drying process to gain biology albumen feedstuff raw material. The invention could effectively kill the noxious bacterium and shorten the fermenting time. It realizes effective reusing to the kitchen organic waste materials.

The invention relates to chimeric antigen receptors (CAR), particularly relates to dual-signal independent chimeric antigen receptors (dsCAR), and also relates to immune response cells of the dual-signal independent chimeric antigen receptors (dsCAR) and uses of the immune response cells in preparation of drugs for treatment of malignant tumor and virus infected diseases. In detail, the dual-signal independent chimeric antigen receptors (dsCAR) can respectively identify two different family antigens of tumor cells and can respectively transmit two T-cell-activation related signals. One of the CAR can transmit a first T-cell-activation related signal by combing a ligand of a tumor specific antigen or a tumor-associated antigen to decide T-cell killing specificity, and the other CAR can transmit a second T-cell-activation related signal by combing a ligand of a membrane receptor (such as EGFR (epidermal growth factor receptor) family protein) widely expressed by the tumor cells to promote T cell activation, proliferation and survival. The dual-signal independent chimeric antigen receptors (dsCAR) can avoid the potential safety problems on the basis of maintaining curative effects of second generation and third generation CAR.

The invention discloses a compound microorganism liquid bacterial fertilizer for preventing plant diseases and insect pests and a preparation method of the compound microorganism liquid bacterial fertilizer and belongs to the technical field of microorganisms. The bacterial fertilizer comprises raw materials of, by weight, 10-20 parts of paprika powders, 10-20 parts of chilli powders, 5-15 parts of ginkgo leaf powders, 5-15 parts of chinaberry powders, 5-15 parts of lightyellow sophora root powders, 20-40 parts of mashed garlic, 40-80 parts of molasses, 4-8 parts of soybean meal, 5-15 parts of calcium sulfate, 5-15 parts of magnesium chloride, 5-10 parts of salt, 5-15 parts of photosynthetic bacterium strains, 5-15 parts of saccharomycete strains, 5-15 parts of lactic acid bacterium strains, 5-15 parts of streptomyces jingyangensis strains, 5-15 parts of bacillus subtilis strains and 800 parts of water. According to the compound microorganism liquid bacterial fertilizer, probiotic floras which are screened and are capable of coexisting are used for fermenting plant leaching agents of pepper, chilli, ginkgo leaves, chinaberry, lightyellow sophora roots and garlic, the plant leaching agents are capable of expelling and killing the insect pests and harmful bacteria, the compound microorganism liquid bacterial fertilizer has the advantages of being high in content of live bacteria of probiotics, high in activities, high in stability, small in using amount of plant materials, fast in acting effects, non-toxic and environment-friendly, and has wide application prospects in agricultural planting.

The invention relates to a method for preparing a small intestinal submucosa (SIS) soft tissue repair patch, and the soft tissue repair patch prepared by the method. The invention also relates to application of the soft tissue repair path to tissue repair.

The invention discloses a freeze beverage containing isomaltose hypgather and process for preparation, wherein the raw materials comprise the following constituents (by weight ratio): cow's milk and / or dairy product and / or dairy product analogues 0-90%, isomaltose hypgather 0. 01-10. 0%, sugar 4. 0-16. 0%, stabilizing agent 0. 1-1. 0%, sour flavor agent 0-0. 7%, edible flavoring essence 0. 01-0. 4% and balancing water.

The present invention relates to a biocompatible, three-dimensional scaffold useful to grow cells and to regenerate or repair tissue in predetermined orientations. The scaffold is particularly useful for regeneration and repair of cardiac tissue. The scaffold contains layers of alternating A-strips and S-strips, wherein the A-strips within each layer are aligned parallel to each other and preferentially promote cellular attachment over attachment to the S-strips. Methods of producing and implanting the scaffold are also provided.

The invention comprises a composite microbial agent applicable to efficiency enhancement of common chemical industry sewage treatment systems. The composite microbial agent applicable to efficiency enhancement of the common chemical industry sewage treatment systems meets the demands on treatment on comment pollutants in existing chemical industry and environmental production as well as on establishment of functional bacteria required by a stable bacteria flora. According to one of the schemes, the composite microbial agent is composed of 108 microorganisms of three major functional types. When the composite microbial agent is added together with microbial growth promoting carriers, nutrient agents and the like into a biochemical system, the composite microbial agent can promote establishment of a complete food chain in the biochemical system through various microorganisms with special pollutant degrading capabilities and comprehensive metabolic manners to enhance utilization and metabolic decomposition of pollutants in sewage through the microorganisms, thereby achieving efficient reduction of COD (chemical oxygen demand), ammonia nitrogen, phosphorous, sulfur and like.

Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.

The invention relates to a method for preparing a biomaterial of acellular small intestinal submucosa, which comprises the steps of preposition treatment, acellular treatment, enzyme treatment, preparations of membranous products and particle products. Compared with the prior art, the biomaterial has higher bioactivity and biocompatibility, no obvious immune rejection and no toxic effect on cells; besides, the biomaterial has a certain mechanical strength and toughness, and variable shape, size and thickness, thereby being convenient for clinical suturing and fixing. At the same time, the preparation method has the advantages of unlimited raw material source, cell-free residues, no ethical issues and being capable of effectively inactivating virus. The prepared products are applicable to the biomedical engineering fields, such as repairing defections of body tissue, serving as tissue filling materials, repairing facial depression deformity, serving as tissue reinforcements to replace fascia, repairing membranous defections and malnourished and infected surfaces of wound, serving as materials for biodegradable stents, and serving as injectable filling materials.

The invention provides a Chinese medicine residue organic fertilizer. Wastes after extraction of Chinese traditional medicines can be fully utilized, utilization of waste materials is realized, and a bactericidal and insect disease preventing organic fertilizer full of nutritional ingredients is also provided for agricultural production. The Chinese medicine residue organic fertilizer is prepared by fermenting Chinese medicine residue, excrement of animals, solid waste, bacillus subtilis and EM. The Chinese medicine residue organic fertilizer has the advantages that the Chinese medicine residue, excrement of animals and solid waste are mixed, biological fermentation bacteria are added for carrying out rapid fermentation, organic fertilizer is processed, waste materials are changed into things of value, harm is turned into good, the problem of treatment of abandoned herb residue produced by a Chinese medicine factory is solved, and waste treatment cost is also greatly reduced, so that a win-win situation of environmental protection and economic development is realized. By adopting the organic fertilizer made from the Chinese medicine residue, soil can be effectively improved, crop pest also can be effectively prevented, and quality, yield and safety of crops are improved.

The invention discloses a composite capable of promoting skin micro-ecological balance and a preparation method of the composite. The composite comprises the following main ingredients of skin prebiotics alpha-glucan oligosaccharide, fructooligosaccharide, beta-glucan, plant extract, yeast extract and natural antibacterial agent leuconostoc / radish root fermentation product filter liquor. According to the composite, micro-ecological balance of the skin can be fundamentally adjusted, skin health is kept, the defects that traditional cosmetics or skin care products cure symptoms, not diseases and are prone to generating side effects are overcome, and the composite has the moisture preservation, softening and tightening multi repair effects, and provides a new thought for solving the skin problems. The preparation method of the composite is simple and practicable, and active ingredients of the functional components are kept to the maximum degree by reasonably controlling reaction steps and mixing temperature.

The present invention relates to an active peptide feed addictive, as a mixture of one or more plant protein and animal protein, which is the product of the following steps: fermenting and degrading the mixture through bacillus and the like, controlling the degree of hydrolysis at 20-35%, obtaining a fermentation supernatant after a separation post-processing process, concentrating drying the supernatant or directly adsorbing the supernatant onto the carrier, and then low temperature drying it. Said active peptide feed addictive is capable of obviously depressing development of bacillus coli and salmonella, and can prevention and cure diarrhea caused by bacilli or lienteric diarrhea; can exert its functions at a very low concentration, with a very intense effect; can regulate stomach and intestine bacterium group and promote animals digestion functions; can excite animal immune function, reinforce animal disease resistance against a plurality of epidemic diseases and greatly reduce the morbidity and death rate; can promote animal development and improve the growth velocity; can improve the feed use ratio and reduce production costs. Applications of the microorganism fermentation degradation method provided by the present invention have a low fabricating cost, and the obtained peptides have many kinds and high content, without environment pollutions.

The invention relates to a CD47 and PD-L1 targeting bifunctional fusion protein, belongs to the field of biomedicine, and solves the problems that anti-PD-1 / PD-L1 treatment is poor in a low-immunogenicity tumor treatment effect and anti-CD47 treatment is poor in a targeting ability. The fusion protein is composed of a CD47 binding part and a PD-L1 binding part which are linked by a disulfide bond, can block the binding of CD47 and SIRPalpha, can block the binding of PD-L1 and PD-1, can achieve the effects of activating macrophages to phagocytize tumor cells and promoting antigen presentation in natural immunity, can achieve an effect of promoting the activation of tumor specific T cells in acquired immunity, and has lower blood toxicity; and as compared with the single use of anti-PD-L1 or anti-CD47 for treatment, the fusion protein has better antitumor curative effects and blood safety.

The present invention relates to female germline stem cells and their progenitors, methods of isolation thereof, and methods of use thereof.

The invention provides a lactobacillus helveticus microcapsule as well as the preparation and application thereof, pertaining to the embedding technology of lactobacillus helveticus and aiming at microencapsulating the lactobacillus helveticus so as to solve the problems of low embedding efficiency and embedding yield in single-layer or double-layer embedment. The technical proposal adopted by the invention is that isolated soy protein, microporous starch and sodium alginate are respectively taken as the first, the second and the third layers of wall materials for microencapsulation; the three-layer embedment is carried out to the lactobacillus helveticus for the first time, wherein, in the process of preparing bacterial suspension, an orthogonal optimization protective agent is adopted to improve the livability after freeze drying. The microcapsule of the invention has strong heat resistance and acid resistance, solves the inactivation problem caused by gastric acid, digestive enzyme and antibiotic, etc. to active bacillus, is capable of releasing when reaching large intestine, and balances intestinal flora. The reusability of fermented milk is good. The lactobacillus helveticus used by the invention enriches the variety of probiotic bacteria microcapsule and is a good dietary supplement.

The invention relates to infant formula milk powder and a production method thereof. The infant formula milk powder contains nutrition constituents such as protein, fat, carbohydrate, vitamins, mineral elements and the like with content regulated by the national standards on infant foods. Moreover, whey peptides, collagen peptides and casein phosphopeptides are added in the milk powder. Since the three kinds of binding peptides are added, the invention has the advantages that the immunity of cesarean infants is improved and the disease resistance of the infants is enhanced; the digestive function of the infants is improved, the intestinal mucosa proliferation is promoted and the digestive function is improved; and the development of the nervous system is promoted, the nutrition supply to the nervous system is guaranteed and the memory and the learning ability of the infants are improved.

The invention relates to natural attractants, belonging to the field of feed additives. One natural attractant is mainly composed of a dried tangerine peel crushed substance, a hawthorn crushed substance, a cinnamon crushed substance, a mugwort leaf crushed substance, and composite microbial powder. The other natural attractant is mainly composed of a dried tangerine peel extractive, a hawthorn extractive, a cinnamon extractive, a mugwort leaf extractive, and composite microbial powder. The attractants provided by the invention has the advantages of promoting the ingestion of livestock, poultry and aquatic animals, increasing the ingestion speed and feed intake of the livestock, poultry and aquatic animals, avoiding the indigestion caused by overfeeding, increasing the feed intake and digestibility of the animals to the feeds hard to digest, expanding the application range and usage amount of unconventional feed materials, enhancing the immunity and anti-stress capability of the animals, resisting diseases, promoting growth, decreasing the production cost of the animal feeds and increasing the production benefits; the attractants contain no antibiotic and chemical medicine as well as drug residue, can be used for a long time without causing drug resistance, and have safety and high efficiency.

The invention belongs to the technical field of polluted ground water remediation, and particularly relates to a method and a system by using micro-namo bubbles to perform reinforcement in-situ remediation on polluted ground water. The method comprises the steps of: arranging a water injection well at the upper reaches of a region with ground water polluted by pollutants, and feeding micro-nano bubble water containing nutrient salts; leading the micro-nano bubble water to flow to the polluted region with the ground water, so as to decompose the pollutants or continuously compensate electron acceptors or electron donors for microorganisms and facilitate degradation and removal of organic pollutants; at the same time, arranging a water pumping well to pump water at lower reaches of the polluted region, so as to form a subsurface flow field; and using a monitoring well to monitor and analyze parameters in real time during the process of removing the organic pollutants, and adjusting the generating time and the aeration intensity of the micro-nano bubbles. According to the invention, the micro-nano bubbles are good in oxygen supply effect, long in lasting time and wide in influencing range, the method and the system provided by the invention can make up the shortages of common in-situ remediation technologies such as natural degradation, bioventing and the like and are low in cost and high in energy-saving efficiency, thereby being applicable in remediation for a field with a limit area and a high pollution load.

The invention discloses a bionic three-dimensional tissue engineering scaffold, which is formed by high molecular fibrous membrane-loaded active growth factors, or active growth factors loaded on a composite scaffold formed by a high molecular fibrous membrane and a macropore spongy layer. With the adoption of the bionic three-dimensional tissue engineering scaffold, the problem that the concentration of active molecules loaded with an emulsion electricity texture fibrous membrane is low; the emulsion electricity texture fibrous membrane is combined with a macropore spongy or a mixed electricity texture process, so that the load rate of the active factors can be greatly improved; parts of factors are retained in the fiber through an emulsion electricity texture core-shell structure, so that the effective control of releasing time is realized, and a repairing process is monitored for a long time; and the introduction of active molecules in the scaffold plays guiding and promoting functions for proliferating regenerative cells, directionally differentiating, migrating and adhering cells, and capturing stem cells to introduce regenerative functions of newly born tissues, so that a new path is provided for development of regenerative medicine industries.

Methods of ex-vivo culture of natural killer (NK) cells are provided and, more particularly, methods for enhancing propagation and / or functionality of NK cells by treating the cells with a nicotinamide or other nicotinamide moiety in combination with cytokines driving NK cell proliferation. Also envisioned are compositions comprising cultured NK cells and therapeutic uses thereof.

The invention belongs to the technology field of formula foodstuff with homology of medicine and food, and concretely relates to edible special meal for patients with tumor. Partial lump is formed by abnormal hyperplasia of cells of partial tissue under the effects of various tumorigenesis factors of body. The malignant tumor can destroy structure and function of tissue and organ, thereby inducing necrotic hemorrhage concurrent infection, and the patient finally may die due to exhaustion of organ function. The invention combines food material with homology of medicine and food as well as new resource foodstuff perfectly, and combines diet and health preserving organically, thereby using a plurality of probiotics creatively based on inherits of traditional Chinese medicine healing methods for conditioning and preventing and inhibiting tumor, and adjusting microecology balance in intestine and enhancing taste movement function; according to the characteristics of tumor, a plurality of natural and original medicine and food materials with homology are added, so the invention has unique advantages integrated with dietotherapy, prevention and conditioning three efficacies.

The invention provides a multifunction active agent of fermentation beds. Chinese herbal medicament components are added in the active agent to kill ova and increase lean meat yield. The aim of the invention is realized by comprising the compositions in portion: 2 portions of zymogen and the following Chinese herbal medicaments: 0.1 to 0.5 portion of folium cortex eucommiae, 0.1 to 0.5 portion of glossy privet fruit, 0.5 to 2 portions of hawthorn, 0.5 to 2 portions of astragalus root and 0.1 to 0.8 portion of Chinese cinnamon. The multifunction active agent is characterized in that the active agent ensures that livestock and poultry excretions undergo fermentation in the fermentation beds to provide abundant organic fertilizer for plants and that the temperature generated by fermentation creates favorable growth conditions for livestock, poultry and plants; harmless treatments such as quick fermentation, decomposition, adsorption, disinfestation and ovum killing of the livestock and poultry excretions are carried out through beneficial strain and the Chinese herbal medicaments; meanwhile, the added Chinese herbal medicaments can promote the multiplication of beneficial bacteria in pig intestines so as to accelerate growth; and lean meat ratio can be increased by approximately 15 percent.

The invention includes a cell-growth-on-bead assay for screening a one-bead-one-compound combinatorial bead library to identify synthetic ligands for cell attachment and growth or proliferation of epithelial and non-epithelial cells. Cells are incubated with a compound bead library for 24 to 72-hours, allowing them to attach and grow on the beads. Those beads with cells growing are removed, and the ligand on the bead is identified. Also provided are ligands specific for cancer cells.