108results about How to "Increase intake" patented technology

The invention discloses a preparation method of a zinc-dihydromyricetin nano-enzyme and application of the zinc-dihydromyricetin nano-enzyme in preparation of drugs for promoting healing of diabetic wounds, and the zinc-dihydromyricetin metal polyphenol nano-enzyme (Zn-DHM) is obtained by coordinating a metal element zinc (Zn) and a natural product dihydromyricetin (DHM) through a one-step method by taking PVP as a surfactant. The Zn-DHM nano-enzyme prepared by the invention has antioxidant property and cell proliferation and migration promoting ability, and can maintain metabolism and immune homeostasis of diabetic wounds, so that the Zn-DHM nano-enzyme can accelerate early healing of the diabetic wounds.

The invention provides organic nanoparticles with high osteogenic performance as well as a preparation method and application thereof, and belongs to the technical field of osteogenic drug preparation. The preparation method of the organic nanoparticles with high osteogenic performance comprises the following steps: (1) preparing fluorinated polyethyleneimine, preparing double bonds from the fluorinated polyethyleneimine, and then grafting a targeting peptide E7 to obtain a carrier F-PEI-E7; and (2) entrapping an osteogenesis promoting drug in the carrier F-PEI-E7 to obtain the organic nanoparticles with high osteogenesis performance. The invention provides an innovative strategy: F-PEI is used as a carrier, an osteogenesis promoting drug (beta-GP) is entrapped, and through E7 targeting peptide (EPLQLKM) modification, precise targeting delivery of the drug is realized. The organic nanoparticles are high in stability, the in-vitro osteogenesis promoting effect is equivalent to that of a classical formula for in-vitro osteogenesis induction, and the organic nanoparticles have an excellent in-vivo osteogenesis promoting effect.

The utility model relates to the field of visual detection equipment, in particular to blow molding part appearance visual detection equipment which comprises a detection box, the placement table is fixedly connected to the inner side of the detection box; the detection mechanism is arranged opposite to the placement table and is connected with the detection box; wherein the detection mechanism comprises a detection assembly, and the detection assembly is arranged on the inner side of the detection box; the adjusting assembly is arranged between the detection assembly and the detection box; the cleaning assembly is connected with the detection assembly and is used for blowing dust to the detection assembly; the brushing and sweeping assembly is connected with the detection assembly and connected with the cleaning assembly, the cleaning assembly is arranged and matched with the brushing and sweeping assembly, dust on the detection assembly can be rapidly cleaned, a photographing device can conveniently obtain a clear image, and the detection effect can be improved.

The invention discloses an application of inulin in preparation of a medicine for treating polycystic ovarian syndrome, especially the polycystic ovarian syndrome caused by high fat diet. Starting from the pathogenesis of the PCOS, research is carried out in the direction of'regulating host-intestinal dialogue by dietary fibers, promoting a tryptophan-quinolinic acid metabolic pathway to enhance an NAD + de novo synthesis pathway and improving PCOS oxidative stress and insulin resistance ', pathophysiology of the PCOS is researched from a brand new perspective, and the pathogenesis of a patient suffering from the PCOS is comprehensively researched in combination with metabonomics. And a new thought and a new target spot are provided for subsequent treatment.

The invention relates to a water-in-oil nanoemulsion with high drug loading capacity as well as a preparation method and application of the water-in-oil nanoemulsion. The water-in-oil nanoemulsion is prepared by dropwise adding a water-phase solution containing tocoxolam into an oil-phase solution, the water-phase solution is prepared from tocopherol, a cosurfactant, a hydrophilic active matter, a preservative and water; the oil phase solution is composed of liquid grease and a surfactant; the water-in-oil nanoemulsion is prepared from the following components in percentage by mass: 50 to 64 percent of liquid grease, 10 to 17 percent of surfactant, 5 to 8 percent of tocoxolam, 5 to 12 percent of surfactant, 0.1 to 6 percent of hydrophilic active matter, 0.2 to 0.6 percent of preservative and 8 to 15 percent of water. The water-in-oil nanoemulsion has the advantages of high drug loading capacity, good skin permeability, high retention volume in skin cells, high bioavailability, good stability, high safety and the like, and can be used in pure oil cosmetics.

The invention relates to a radiolabeled FAPI complex as well as a preparation method and application thereof, and belongs to the technical field of radiopharmaceutical chemistry and nuclear medicine diagnosis and treatment. The structural general formula of the FAPI capable of being subjected to radionuclide labeling is as follows: # imgabs0 #, wherein R is a nitroimidazole group or-COOH; x is a chelating group or a chelating structure of a chelating radionuclide; l1 and L2 are linking groups; a is a regulating atom of an FAP targeting group, and A is an H atom or an F atom. The synthesis method of the radionuclide labeling precursor is simple and suitable for labeling of various nuclides, the labeling method is convenient and fast, and the radiochemical purity of the label is high, and the stability is good; the radiolabeled FAPI complex shows high affinity and specificity with FAP in cell experiments, shows high tumor uptake and target-to-non-target ratio in tumor-bearing mice, and is a potential FAP targeted radioactive diagnosis and treatment drug.

The invention relates to an endoplasmic reticulum targeting polypeptide nano-drug with glutathione responding to morphology transformation, a preparation method and a related performance characterization method. The endoplasmic reticulum targeting polypeptide nano-drug with glutathione responding to morphology transformation comprises a targeting unit, an assembling unit and a functional unit, wherein the targeting unit comprises one or more of targeting peptide sequences RVMLIGK, RVMLIEK, KDEL and sulfonyl groups with an endoplasmic reticulum targeting function; the functional unit comprises a glutathione response group disulfide bond, and the assembly primitive sequence and the assembly regulation sequence are covalently connected through the disulfide bond. The assembly structure of the polypeptide nano-drug has sensitive glutathione responsiveness, so that the polypeptide nano-drug can generate assembly morphology transformation in glutathione overexpressed tumor cells, and the polypeptide nano-drug is simple and convenient to synthesize and prepare and has wide application prospects in the aspects of drug delivery, tumor treatment and the like.

The invention relates to the technical field of health-care products, in particular to a health-care product rich in momordica charantia polypeptide and capable of regulating blood sugar metabolism and promoting insulin secretion, momordica charantia polypeptide can stimulate pancreatic beta cells to secrete insulin, and insulin is the only hormone capable of reducing blood sugar in a human body. The balsam pear polypeptide component in the balsam pear extract is specially used for reducing the blood sugar level and improving related health problems, the application of the balsam pear polypeptide in the health care product can effectively regulate the blood sugar metabolism of a human body and promote the secretion of insulin, and the balsam pear polypeptide stimulates pancreas islet beta cells to promote the secretion of insulin. In addition, the balsam pear polypeptide can improve the insulin resistance, increase the number of insulin receptors or enhance the activity of the insulin receptors, so that the body cells are more sensitive to the insulin, the uptake and utilization of glucose are promoted, and the abnormal increase of the blood glucose level is avoided.

The invention provides an application of a selenium-containing preparation in a drug for antagonizing NK cell injury caused by chemotherapy and a drug for antagonizing cisplatin or adriamycin induced NK cell injury. At present, common cancer treatment methods include operative treatment, chemotherapy, radiotherapy and immunotherapy, and chemotherapy is still a main treatment means for most advanced malignant tumors. Meanwhile, chemotherapy has an inhibition effect on an immune system, which is mainly manifested in that the immune system of a patient is damaged and T cells and NK cells are reduced due to direct killing of chemotherapy drugs on immune cells, so that the normal physiological function of the immune system is influenced, tumor cells can be induced to generate immune tolerance, and the metastasis of the tumor cells is accelerated. The selenium-containing preparation is applied to antagonism of induced damage of cis-platinum or adriamycin to NK cells, damage of cis-platinum or adriamycin to NK cells can be antagonized, and effectiveness of chemotherapy and immunotherapy is improved.

The invention belongs to the technical field of noodles, and discloses probiotic golden corn noodles and a preparation method thereof, and the method comprises the following steps: preparing probiotic corn fermented flour and preparing the probiotic golden corn noodles. The preparation of the probiotic corn fermented flour comprises the steps of strain activation and amplification culture, preparation of a mixed leavening agent, preparation of raw materials, inoculated fermentation, cleaning, pulping, curing and mixing, drying and grinding. The preparation method of the probiotic golden corn noodles comprises the steps of raw material preparation, dough preparation and noodle forming. The probiotic golden corn noodles disclosed by the invention have the beneficial effects of promoting intestinal health, controlling blood sugar and blood fat, enhancing immunity and improving mouth feel and flavor, so that the probiotic golden corn noodles become a healthy and delicious food choice.

The invention belongs to the technical field of medicines, and particularly relates to a linarin targeted slow-release nano drug-loading system as well as a preparation method and application thereof. A polylactic acid-polyglycolic acid copolymer is used as a matrix, polyvinyl alcohol is used as a cross-linking agent, and coated drug-loaded microspheres are formed through cross-linking and grafting of the matrix and the cross-linking agent; and then chitosan is used as a protective agent, chitosan and the coated drug-loaded microspheres are crosslinked and grafted to form double-coated composite drug-loaded microspheres, the chitosan in the composite drug-loaded microspheres is used as a shell, the coated drug-loaded microspheres are used as a core, and the linarin targeted slow-release nano drug-loaded system is obtained. Through the double-target design, the targeting property to cornea and lacrimal gland is enhanced, the treatment efficiency of the medicine is improved, stable release and continuous release of linarin are realized, and the problem of unstable release of the medicine is solved; in addition, the targeted slow-release nano drug-loading system is combined with the anti-inflammatory activity and the mitochondrial protection function of linarin, so that the side effects on eyes are reduced, and the safety is improved.

The invention relates to an iRGD modified dual drug-loading liposome and an application of the iRGD modified dual drug-loading liposome in radiotherapy sensitization of targeted glioblastoma. The liposome is composed of HSPC, CHO-HP, DSPE-mPEG2000, and DSPE-PEG2000-MAL, and is loaded with Osimertinib (Osimertinib) and Bortezomib (Bortezomib) through a pH (Potential of Hydrogen) gradient method, and the preparation method of the liposome comprises the following steps: carrying out a reaction on the Osimertinib (Osimertinib) and the Bortezomib (Bortezomib) in the presence of a Osimertinib is used as an EGFR inhibitor, bortezomib is used as a proteasome inhibitor, and osimertinib and bortezomib synergistically enhance the radiotherapy sensitivity by weakening the DNA repair capability of tumor cells. The iRGD peptide on the surface of the liposome is combined with tumor cell specific receptors alpha v beta 3 and NRP1 in a targeting manner, so that the liposome is mediated to pass through tumor neovascularization and efficiently deliver drugs to tumor parts. Animal experiment results show that the enrichment of the liposome in tumor tissues is obviously higher than that of common liposome, and the drug release has good controllability. Compared with the prior art, the invention has obvious advantages in tumor targeting, drug delivery efficiency and radiotherapy sensitization effect, is suitable for combined treatment of radiotherapy drug-resistant glioblastoma, and has a wide clinical application prospect.

The invention discloses a nutritional food capable of improving a night vision function and a preparation method of the nutritional food. The composition is prepared from anthocyanin-sterculia nobilis acid nano-particles, fucoxanthin-vitamin A-resveratrol nano-particles and zinc taurate. The functions of retinal rod cells can be remarkably improved, the blood microcirculation of eyes can be promoted, and the vision sensitivity and the asthenopia resistance in dark environments such as night, weak light and low visibility can be remarkably improved; the product can be prepared into capsules, tablets, electuary, oral liquid or beverage.

The invention provides a nano material suitable for multi-mode diagnostic imaging and targeted photodynamic (PDT) and photo-thermal (PTT) cancer therapy, and belongs to the field of nano biomedicine. According to the invention, an upconversion material (NaYF4: Yb / Er / Gd) and a photo-thermal material (Bi2Se3) are taken as a core, mesoporous silica is taken as a shell, and a photosensitizer (Ce6) and lipid / PEG and acidity-triggered membrane (ATRAM) peptide coated on the surface of the shell are loaded. The PDT and PTT synergistic anticancer effect achieved through near-infrared laser induction is achieved, magnetic resonance imaging, thermal imaging and fluorescence imaging of tumors can be achieved, and the requirement for diagnosis and treatment integration is met. In addition, the in-vivo lifetime of the nano-carrier is effectively prolonged through lipid / PEG, and aggregation and premature degradation of the nano-carrier are prevented; and the pH-mediated acidity-triggered membrane peptide is utilized to improve the uptake of cancer cells to the nano-carrier, so that the effect of the nano-carrier and the cancer cells is enhanced.

The invention provides a shortening grease composition and a preparation method thereof. Specifically, the invention provides the grease composition which comprises branched fatty acid triacylglycerol and base oil, wherein in terms of the total weight of fatty acid of the grease composition, the content of branched fatty acid in the grease composition is 2.50-9.00 wt%. The invention also provides an application of the grease composition and a method for reducing the crystallization rate of palm oil-based shortening, reducing the increase rate of the grease hardness after storage and delaying the subsequent hardness of the palm oil-based shortening. According to the invention, not only can the properties of the shortening be improved, but also the intake of branched chain fatty acid is increased, and a certain positive effect can be achieved in the aspects of cancer resistance, inflammation resistance and the like.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a hydrazino-modified natural polyamine-naphthalimide conjugate as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, introducing hydrazino to the tail end of a polyamine chain, further prolonging the length of the polyamine chain, and finally, conjugating parent nucleus naphthalimide to synthesize a series of hydrazino-modified natural polyamine-naphthalimide conjugates. The compound synthesized by the invention comprises a substituent-free type of parent nucleus naphthalimide, a 3-site amino substituted type of parent nucleus naphthalimide and a 4-site chlorine substituted type of parent nucleus naphthalimide. The conjugate disclosed by the invention solves the problems of poor solubility, relatively complicated clinical compatibility, poor patient immunity in clinical application of chemotherapeutic drugs and the like of the naphthalimide analogue represented by the dinafide in the prior art, and also has relatively good targeting property. According to the conjugate disclosed by the invention, the targeting property and bioavailability of a drug on tumor cells can be improved by utilizing the polyamine transporter highly expressed on the surfaces of the tumor cells, and the toxic and side effects on normal cells are reduced.

The invention relates to the technical field of biological medicines, and discloses hyaluronic acid modified metal coordination albumin nanoparticles as well as a preparation method and application thereof. The hyaluronic acid modified metal coordination albumin nanoparticle comprises a core and a hyaluronic acid shell layer, wherein the core is formed by self-assembly of an albumin-drug compound, poly-L-aspartic acid and ferric ions through coordination, and the hyaluronic acid shell layer is connected to the surface of the core through coordination or adsorption. According to the hyaluronic acid modified metal coordination albumin nanoparticles as well as the preparation method and the application thereof, the preparation method is simple, convenient and rapid, does not need complex covalent modification, is mild in condition and is easy for large-scale production, and the prepared nanoparticles are uniform in particle size, good in stability and high in stability. In addition, due to the fact that the hyaluronic acid is modified on the surface, the active targeting capacity on CD44 receptor high-expression tumor cells is achieved, the enrichment and treatment effects of the medicine on the tumor site are remarkably improved, and the application prospect in preparation of the anti-tumor medicine is wide.

The present application relates to the technical field of biological medicine, and discloses inhalable aptamer modified molybdenum disulfide nanoflower compound and application thereof.The compound comprises a molybdenum disulfide nanoflower core, a dendritic polylysine modification layer attached to the surface of the molybdenum disulfide nanoflower, doxorubicin loaded on the molybdenum disulfide nanoflower and / or the dendritic polylysine modification layer, and AS1411 aptamer combined on the outer surface of the dendritic polylysine modification layer by electrostatic assembly.The compound can be delivered to a lung lesion by atomization inhalation or aerosol inhalation, and undergoes responsive structural change under the action of hydrogen peroxide in a tumor microenvironment, generates active oxygen, and promotes the release of doxorubicin, so as to realize the synergistic antitumor effect of chemotherapy and chemical dynamic therapy.The compound has good colloidal stability, drug loading capacity, active targeting ability and lung local delivery potential, and can be used for preparing inhalation preparations or local administration preparations for treating lung cancer.

The application relates to the field of biological medicine, and particularly discloses application of a polypeptide in preparation of a specific targeting molecular probe for tumors with DLL3 overexpression. The application finds that a molecular probe prepared from a polypeptide shown in SEQ ID No. 4 can effectively target tumor tissues with DLL3 overexpression, thereby providing application of a polypeptide or a dimer or a multimer thereof in preparation of a specific targeting molecular probe for tumors with DLL3 overexpression, wherein the amino acid sequence of the polypeptide is shown in SEQ ID No. 4. The molecular probe of the application has high imaging precision, good affinity with DLL3, can realize early diagnosis and imaging of tumor tissues, and can also be used for preoperative and intraoperative image navigation, thereby improving the operation accuracy.

The present invention relates to a composition for lowering blood sugar, blood lipid and blood pressure and a preparation method thereof, belonging to the field of biotechnology, and the composition comprises a Cyclocarya paliurus flower extract, a chicken heart extract, a mandarin fish head extract and a Gracilaria extract; the Cyclocarya paliurus flower extract is obtained by enzymolysis of Cyclocarya paliurus flower by hemicellulase and bromelain, and then by ficin; the chicken heart extract is obtained by graded enzymolysis of chicken heart by pepsin and subtilisin; the mandarin fish head extract is obtained by fermenting mandarin fish head by Aspergillus niger, and then by trypsin; the Gracilaria extract is obtained by graded enzymolysis of Gracilaria by acid protease and trypsin. The composition has good effects of lowering blood sugar, blood lipid and blood pressure, can be used for preventing and treating cardiovascular and cerebrovascular diseases, softening blood vessels, improving microcirculation, reducing three high symptoms, and has no toxic side effects.

The application discloses an LDH-based vaccine adjuvant and a preparation method and application thereof, and belongs to the technical field of aluminum adjuvant preparation of vaccines, and the preparation method comprises the following steps: mixing at least one of soluble magnesium salt, soluble zinc salt, soluble manganese salt and soluble calcium salt with soluble aluminum salt, and then performing a co-precipitation reaction with a sodium hydroxide aqueous solution in a colloid mill device, and performing crystallization to obtain LDH nanosheets; dispersing the LDH nanosheets in a PBS solution, adding a hepatitis B surface antigen molecule drug, uniformly mixing, and then performing centrifugation to obtain the LDH-based vaccine adjuvant. The LDH-based vaccine adjuvant can significantly promote the maturation of DC cells and the activation of T cells, and the total IgG level reflects the overall humoral immune response intensity of the body to vaccines or pathogens; the LDH-based vaccine adjuvant forms a "storage library" at an injection site to store antigens and slowly release the antigens, and the purpose of long-time continuous stimulation of the immune system in the body is achieved.

The invention relates to an oat peptide rich in prebiotics and a preparation method thereof, and belongs to the technical field of biology, the product adopts oat peptide, prebiotics, wall-broken oat powder, white hyacinth bean powder, roxburgh rose powder and lotus seed powder as main raw materials; wherein the oat peptide is the oat peptide which is 5kDa or below and is obtained by sequentially carrying out step-by-step enzymolysis on oat protein through papain, snail protease and nattokinase; the white hyacinth bean powder is an extract obtained by performing common enzymolysis on white hyacinth beans through cellulase and pectinase and then sequentially performing step-by-step enzymolysis on the white hyacinth beans through trypsin and papain; the lotus seed powder is an extract obtained by performing common enzymolysis on peeled lotus seeds through cellulase and pectinase and then sequentially performing step-by-step enzymolysis through fig protease and papain. The product follows the functions of clearing, regulating and nourishing, all aspects are matched in a balanced mode, the digestion and absorption rate is increased, blood toxins and intestinal waste are removed, blood sugar and blood fat are reduced, immunity is improved, mood comfort is facilitated, and nerve soothing and sleep aiding are achieved; the effect is prominent, rapid and safe without side effects.

The invention relates to the technical field of biological material manufacturing, in particular to vanadium-doped mesoporous bioactive glass powder for treating diabetic wounds and a preparation method of the vanadium-doped mesoporous bioactive glass powder. Adding an ammonia solution into the template agent solution to obtain a mixed solution; adding a silicon source, a phosphorus source, a calcium source and a vanadium source into the mixed solution in batches according to a preset interval time under a continuous stirring condition, continuously stirring and reacting for 5.5-24 hours, and centrifuging and collecting a precipitation product; and washing, roasting and grinding the obtained precipitation product to obtain the vanadium-doped mesoporous bioactive glass powder for treating diabetic wounds.

The present invention relates to a composition containing the following components (A) and (B), that can widely suppress off-tastes of food and drink: (A) at least one γ-glutamyl peptide selected from the group consisting of a compound represented by the formula (I):         γ-Glu-X-Gly     (I) wherein X is an amino acid residue or an amino acid derivative residue, and a compound represented by the formula (II):         γ-Glu-Y     (II) wherein Y is an amino acid residue or an amino acid derivative residue, or a salt thereof, and (B) at least one selected from the group consisting of citronellal, limonene, 2-methylpyrazine, butanoic acid, methyl anthranilate, and nootkatone.

The application relates to a double-channel rotating detonation combustion chamber structure with an inlet total pressure adjusting function, which comprises a Tesla valve arranged at the inlet of the rotating detonation combustion chamber, the Tesla valve comprises a shell and a flow channel, the inlet end and the outlet end of the flow channel are respectively provided with pressure adjusting structures, the radial outer side of the flow channel is provided with an injection channel, the injection channel comprises an air outlet channel and a pressurizing channel communicated with the air outlet channel, and the side, away from the pressurizing channel, of the air outlet channel is provided with an opening and closing assembly for opening or closing the air outlet channel, the opening and closing assembly comprises a supporting plate, a plurality of opening and closing doors and a self-locking driving part, and the self-locking driving part is used for synchronously driving the plurality of opening and closing doors to be close to or away from the outlet side of the air outlet channel. The application has the effects that when the rotating detonation combustion chamber is in an air thin belt, the air intake of the air inlet channel is automatically enhanced, the rotating detonation combustion chamber preferentially intakes the air in the air inlet channel, the air supply of the combustion chamber is ensured, and the adaptability and stability of the combustion chamber in different environments are improved.

The invention discloses a preparation method and application of an anti-aging vaccine, and relates to the technical field of medical treatment. Comprising the following steps: 1, synthesizing a polypeptide with a specific sequence; 2, coupling the polypeptide with a carrier protein; adding an immunologic adjuvant, and fully and uniformly mixing at room temperature to obtain a polypeptide solution; 3, freeze-drying the polypeptide solution to obtain a freeze-dried pure product; and dissolving the freeze-dried pure product in ultrapure water, filling into a sterile EP tube, and storing at-20 DEG C to obtain the anti-aging polypeptide vaccine. The anti-aging polypeptide vaccine has the beneficial effects that the polypeptide sequences (A: RRGDGRWKD, B: RSQHLRFPDR, and C: TGRRLFCYS) are designed to create the polypeptide vaccine, and the polypeptide vaccine can effectively act on cells with high expression of GPNMB, so that the anti-aging effect is achieved.

The utility model relates to a welfare cage laying hen house which is characterized in that the welfare cage laying hen house comprises a ground activity area (3), a plurality of activity platforms and a plurality of laying platforms which form at least two layer structures, one layer structure is formed by overlapping the plurality of activity platforms, and the other layer structure is formed by overlapping one or more activity platforms and one or more laying platforms. Or the egg laying platform is formed by stacking a plurality of egg laying platforms; a vertical crossing activity space exists between the two layer structures, and the two layer structures are located on the ground activity area (3) to form a U shape. The laying hens can freely move on any platform between the two layer structures. On the premise that a larger activity space is provided for laying hens, the space height of the henhouse is utilized, a crossed three-dimensional inhabiting platform is provided, the number of the laying hens in unit volume is increased, and the chicken raising cost is reduced.

The invention discloses a high-protein pig feed capable of improving pig immunity, which is prepared from the following substances in percentage by mass: 20 to 35 percent of corn, 10 to 20 percent of bran, 2 to 6 percent of fattening fertilizer, 0.5 to 2 percent of glucose, 0.5 to 1 percent of alkali red mud, 0.1 to 0.5 percent of baking soda, 0.1 to 0.3 percent of table salt, 0.1 to 0.3 percent of mold removal agent, 0.02 to 0.1 percent of sodium selenite vitamin E, 0.02 to 0.1 percent of calcium hydrophosphate, 0.3 to 0.8 percent of ash wood and the balance of alfalfa. The invention has the following beneficial effects: 1, the protein content is high, and the cost is low; 2, the intake of trace elements is improved in daily feeding, and the immunity of the pigs is improved; and 3, safety and effectiveness.

The present application provides a method for producing a Citrus medica L. var. sarcodactylis fermentate with the effect of increasing polyphenol intake and adiponectin content. The method for producing a Citrus medica L. var. sarcodactylis fermentate with the effect of lowering blood lipids comprises the following steps: washing, air-drying, and breaking the cell wall, inoculating and fermenting, comprehensive filtering, sterilizing, and finally forming a Citrus medica L. var. sarcodactylis fermentate that can increase the total polyphenol content in the human body and improve the adiponectin content in the body.

This invention discloses a liposome, a drug-loaded liposome, its preparation method, and its applications. The liposome comprises a liposome backbone and a targeting ligand; wherein the liposome backbone comprises the following components: phospholipids, cholesterol, cationic lipids, and PEGylated phospholipids; the cationic lipids are (2,3-dioleoyl-propyl)-trimethylammonium chloride and / or 1,2-dioleoyl-3-trimethylammonium propane; and the targeting ligands are sodium hyaluronate and / or hyaluronic acid. This liposome possesses excellent basic properties and excellent targeting ability; after encapsulating the active pharmaceutical ingredients (doxacin hydrochloride and berberine hydrochloride), its targeting ability can be further enhanced in practical applications, thereby increasing its efficacy.