23results about How to "Increase intake" patented technology

The invention relates to the technical field of biological medicines, and discloses hyaluronic acid modified metal coordination albumin nanoparticles as well as a preparation method and application thereof. The hyaluronic acid modified metal coordination albumin nanoparticle comprises a core and a hyaluronic acid shell layer, wherein the core is formed by self-assembly of an albumin-drug compound, poly-L-aspartic acid and ferric ions through coordination, and the hyaluronic acid shell layer is connected to the surface of the core through coordination or adsorption. According to the hyaluronic acid modified metal coordination albumin nanoparticles as well as the preparation method and the application thereof, the preparation method is simple, convenient and rapid, does not need complex covalent modification, is mild in condition and is easy for large-scale production, and the prepared nanoparticles are uniform in particle size, good in stability and high in stability. In addition, due to the fact that the hyaluronic acid is modified on the surface, the active targeting capacity on CD44 receptor high-expression tumor cells is achieved, the enrichment and treatment effects of the medicine on the tumor site are remarkably improved, and the application prospect in preparation of the anti-tumor medicine is wide.

The present application relates to the technical field of biological medicine, and discloses inhalable aptamer modified molybdenum disulfide nanoflower compound and application thereof.The compound comprises a molybdenum disulfide nanoflower core, a dendritic polylysine modification layer attached to the surface of the molybdenum disulfide nanoflower, doxorubicin loaded on the molybdenum disulfide nanoflower and / or the dendritic polylysine modification layer, and AS1411 aptamer combined on the outer surface of the dendritic polylysine modification layer by electrostatic assembly.The compound can be delivered to a lung lesion by atomization inhalation or aerosol inhalation, and undergoes responsive structural change under the action of hydrogen peroxide in a tumor microenvironment, generates active oxygen, and promotes the release of doxorubicin, so as to realize the synergistic antitumor effect of chemotherapy and chemical dynamic therapy.The compound has good colloidal stability, drug loading capacity, active targeting ability and lung local delivery potential, and can be used for preparing inhalation preparations or local administration preparations for treating lung cancer.

The application relates to the field of biological medicine, and particularly discloses application of a polypeptide in preparation of a specific targeting molecular probe for tumors with DLL3 overexpression. The application finds that a molecular probe prepared from a polypeptide shown in SEQ ID No. 4 can effectively target tumor tissues with DLL3 overexpression, thereby providing application of a polypeptide or a dimer or a multimer thereof in preparation of a specific targeting molecular probe for tumors with DLL3 overexpression, wherein the amino acid sequence of the polypeptide is shown in SEQ ID No. 4. The molecular probe of the application has high imaging precision, good affinity with DLL3, can realize early diagnosis and imaging of tumor tissues, and can also be used for preoperative and intraoperative image navigation, thereby improving the operation accuracy.

The application discloses an LDH-based vaccine adjuvant and a preparation method and application thereof, and belongs to the technical field of aluminum adjuvant preparation of vaccines, and the preparation method comprises the following steps: mixing at least one of soluble magnesium salt, soluble zinc salt, soluble manganese salt and soluble calcium salt with soluble aluminum salt, and then performing a co-precipitation reaction with a sodium hydroxide aqueous solution in a colloid mill device, and performing crystallization to obtain LDH nanosheets; dispersing the LDH nanosheets in a PBS solution, adding a hepatitis B surface antigen molecule drug, uniformly mixing, and then performing centrifugation to obtain the LDH-based vaccine adjuvant. The LDH-based vaccine adjuvant can significantly promote the maturation of DC cells and the activation of T cells, and the total IgG level reflects the overall humoral immune response intensity of the body to vaccines or pathogens; the LDH-based vaccine adjuvant forms a "storage library" at an injection site to store antigens and slowly release the antigens, and the purpose of long-time continuous stimulation of the immune system in the body is achieved.

The invention relates to the technical field of biological material manufacturing, in particular to vanadium-doped mesoporous bioactive glass powder for treating diabetic wounds and a preparation method of the vanadium-doped mesoporous bioactive glass powder. Adding an ammonia solution into the template agent solution to obtain a mixed solution; adding a silicon source, a phosphorus source, a calcium source and a vanadium source into the mixed solution in batches according to a preset interval time under a continuous stirring condition, continuously stirring and reacting for 5.5-24 hours, and centrifuging and collecting a precipitation product; and washing, roasting and grinding the obtained precipitation product to obtain the vanadium-doped mesoporous bioactive glass powder for treating diabetic wounds.

The application relates to a double-channel rotating detonation combustion chamber structure with an inlet total pressure adjusting function, which comprises a Tesla valve arranged at the inlet of the rotating detonation combustion chamber, the Tesla valve comprises a shell and a flow channel, the inlet end and the outlet end of the flow channel are respectively provided with pressure adjusting structures, the radial outer side of the flow channel is provided with an injection channel, the injection channel comprises an air outlet channel and a pressurizing channel communicated with the air outlet channel, and the side, away from the pressurizing channel, of the air outlet channel is provided with an opening and closing assembly for opening or closing the air outlet channel, the opening and closing assembly comprises a supporting plate, a plurality of opening and closing doors and a self-locking driving part, and the self-locking driving part is used for synchronously driving the plurality of opening and closing doors to be close to or away from the outlet side of the air outlet channel. The application has the effects that when the rotating detonation combustion chamber is in an air thin belt, the air intake of the air inlet channel is automatically enhanced, the rotating detonation combustion chamber preferentially intakes the air in the air inlet channel, the air supply of the combustion chamber is ensured, and the adaptability and stability of the combustion chamber in different environments are improved.

The utility model relates to a welfare cage laying hen house which is characterized in that the welfare cage laying hen house comprises a ground activity area (3), a plurality of activity platforms and a plurality of laying platforms which form at least two layer structures, one layer structure is formed by overlapping the plurality of activity platforms, and the other layer structure is formed by overlapping one or more activity platforms and one or more laying platforms. Or the egg laying platform is formed by stacking a plurality of egg laying platforms; a vertical crossing activity space exists between the two layer structures, and the two layer structures are located on the ground activity area (3) to form a U shape. The laying hens can freely move on any platform between the two layer structures. On the premise that a larger activity space is provided for laying hens, the space height of the henhouse is utilized, a crossed three-dimensional inhabiting platform is provided, the number of the laying hens in unit volume is increased, and the chicken raising cost is reduced.

The present application provides a method for producing a Citrus medica L. var. sarcodactylis fermentate with the effect of increasing polyphenol intake and adiponectin content. The method for producing a Citrus medica L. var. sarcodactylis fermentate with the effect of lowering blood lipids comprises the following steps: washing, air-drying, and breaking the cell wall, inoculating and fermenting, comprehensive filtering, sterilizing, and finally forming a Citrus medica L. var. sarcodactylis fermentate that can increase the total polyphenol content in the human body and improve the adiponectin content in the body.

The present application relates to the technical field of plant extract beverage preparation, in particular to a preparation process and device for a plant extract beverage, the preparation process comprising the following steps: selecting, removing impurities, removing dust and crushing one of tea, American ginseng, dendrobium, astragalus, wolfberry fruit, cistanche, angelica and polygonatum; adding water until the mixture is soaked through to obtain a material-water mixture; extracting the material-water mixture with three times of ethanol of a specified concentration; combining the three times of extraction liquid and conveying the combined extraction liquid into a reduced-pressure concentration tank for reduced-pressure concentration treatment, then eluting the extraction liquid with a macroporous adsorption resin column to obtain a traditional Chinese medicine extract, drying the traditional Chinese medicine extract, mixing the dried traditional Chinese medicine extract with resistant dextrin, stevioside, citric acid, vitamins, beta-cyclodextrin and other auxiliary materials in a mixing machine, sterilizing the mixture, and packaging the sterilized mixture to obtain the plant extract beverage; and the preparation device comprises an extraction device, a reduced-pressure concentration tank, a conveying control device and an adsorption and washing device. The present application adopts an ethanol gradient extraction method to comprehensively extract active ingredients in medicinal materials, and the prepared plant extract beverage is convenient to store, carry and drink.

The invention provides a phosphatidyl glycerol skeleton compound containing a dithiolane structure and application of lipid nanoparticles of the phosphatidyl glycerol skeleton compound in biological medicine, and belongs to the technical field of nucleic acid drug delivery. The structural formula of the compound provided by the invention is as shown in formula I in the specification. The phosphatidylglycerol skeleton compound containing the dithiolane structure provided by the invention takes phosphatidylglycerol as a skeleton, the molecular structure is mainly formed by connecting glycerol, phosphoric acid, fatty acid and fatty acid containing the dithiolane structure through ester bonds, the degradability is stronger, the number of dithiolane in the molecule is large, and the dithiolane skeleton compound containing the dithiolane structure has a good application prospect. The dithiolane derivative has higher efficiency and safety in nucleic acid delivery, and can be used as a functional lipid material for preparing lipid nanoparticles, so that the surfaces of the prepared lipid nanoparticles have dithiolane structures, and the dithiolane derivative can chemically react with sulfydryl on the surfaces of cells, thereby facilitating the uptake of LNP by NK cells and improving the capacity of nucleic acid drugs entering the cells.

The application provides popcorn and a preparation method thereof, and relates to the technical field of popcorn. The popcorn is prepared from pretreated corn kernels, oil and fat components and composite sugar powder. The composite sugar powder comprises isomaltulose, trehalose, allulose, natural inulin and licorice extract powder. The pretreated corn kernels are prepared from corn kernels, stevioside and glucose-based stevioside. The popcorn provided by the application can meet the characteristics of not being sticky, having a crisp taste and not being collapsed in shape. By compounding multiple functional sugar and natural extracts, the technical problems of being sticky, not having a crisp taste and having inconsistent sweet taste distribution in traditional popcorn are solved.

The invention discloses dendrobium officinale oligosaccharide as well as a preparation method and application thereof, and belongs to the technical field of preparation of functional components of natural products. According to the invention, by optimizing the process conditions of enzymolysis of dendrobium officinale polysaccharide by beta-mannase, including substrate concentration, enzyme dosage, pH, temperature and time, and purifying, the dendrobium officinale oligosaccharide (DOO1) with the molecular weight of about 921 Da, the molar ratio of mannose to glucose of about 4.53: 1 and the main glucosidic bond of-> 4)-beta-D-Manp-(1->) is obtained. According to the prepared dendrobium officinale oligosaccharide, the solubility and bioavailability of the dendrobium officinale oligosaccharide are remarkably improved, the good alpha-amylase inhibitory activity is shown, the effect of improving insulin to resist cell glucose uptake is achieved, and the functional application potential of dendrobium officinale is further expanded.

The present application relates to the technical field of household appliances, and provides a coating composition, a coated part and a household appliance. The coating composition prepared according to the present application comprises lapis lazuli powder and an inorganic glue mixed solution in a weight ratio of 1:3 to 1:4; the inorganic glue mixed solution comprises inorganic glue and water in a mass ratio of 1:4 to 1:12, and the inorganic glue comprises clay. The coating composition prepared according to the present application is used to prepare a coating layer, and in the process of heating, strontium in the coating layer is added into liquid in a container, so that trace elements required by human bodies can be added when food and drinks are prepared at home, and the normal needs of human bodies are met.

The application belongs to the technical field of biology, and specifically discloses a method for relieving the adverse effects of glufosinate-ammonium on bumblebees by using astaxanthin. It is found that feeding astaxanthin to bumblebees can effectively relieve the adverse reactions caused by glufosinate-ammonium residues; in terms of the content of active oxygen in the intestinal tract, astaxanthin can significantly eliminate the active oxygen caused by glufosinate-ammonium; in terms of feeding behavior, astaxanthin can significantly restore the reduced feeding amount of bumblebees caused by glufosinate-ammonium exposure; in terms of the integrity of the midgut, astaxanthin can significantly relieve the dissolution of the peritrophic membrane of the midgut of bumblebees caused by glufosinate-ammonium exposure; and in terms of the intestinal microbial layer, astaxanthin can restore the level of core bacteria of bumblebees caused by glufosinate-ammonium exposure. The application also provides bumblebee feed for relieving the toxicity of glufosinate-ammonium and the application of astaxanthin in the preparation of a preparation for relieving the adverse effects of glufosinate-ammonium on bumblebees.

The application provides a kind of nano preparation with antioxidant function and the use for treating glaucoma, the preparation is composed of oil phase and water phase.Oil phase is lecithin, medium-chain triglyceride, fat-soluble antioxidant, glaucoma treatment drug, water phase is water-soluble antioxidant or deionized water.The nano delivery system described in the application is by loading glaucoma treatment drug in the nano preparation containing antioxidant, can improve local drug concentration, prolong drug retention time, at the same time, through antioxidant scavenging excess active oxygen, reduce inflammatory response, reduce eye cell apoptosis, so as to achieve good therapeutic effect.The nano preparation described in the application can be nano emulsion, liposome, micelle or lipid nanoparticle and other drug delivery systems.The nano preparation can deliver therapeutic drugs while scavenging ROS, reducing eye inflammation and reducing cell apoptosis to achieve more efficient therapeutic effect, with the characteristics of double effect, easy to produce and prepare, wide application range, etc.

The application provides an antibody conjugate drug targeting VEGFR2 and a preparation and application thereof. The antibody conjugate drug is synthesized by an amide reaction of an antibody fragment anti-VEGFR2 F(ab')2, a connecting bond ketone condensed thioalcohol and a model drug. A kidney disease antibody conjugate drug preparation platform is established by using anti-VEGFR2 F(ab')2 and a ketone condensed thioalcohol bond, and the anti-VEGFR2 F(ab')2 conjugated model drug can improve kidney distribution of the model drug, improve kidney cell uptake, block VEGFR2 and play a kidney disease treatment role, so that multi-target point treatment of the antibody-drug is realized. The antibody conjugate drug provided by the application can be applied to preparation of a kidney disease targeted treatment drug, can significantly improve kidney disease treatment effect of the model drug, and can be widely applied to the fields of life science and pharmacy. A structure of the antibody conjugate drug is shown in formula 1.

The application provides a sialic acid modified hypoxia-responsive chitosan nitrobenzene graft and preparation and application, wherein part of the amino groups of chitosan are substituted by nitrobenzene and sialic acid molecules. The application is based on the hypoxia-responsive chitosan nitrobenzene graft, uses double-end amino polyethylene glycol 2000 as a bridging molecule, chemically modifies sialic acid molecules, and efficiently encapsulates the drug ambrisentan. This not only increases the water solubility and in-vivo circulation time of the drug, but also has the ability to actively target the pulmonary artery endothelium through the interaction with the high expression of E-selection of the pulmonary artery endothelial cells in hypoxic pulmonary arterial hypertension, and is transported to the pulmonary artery smooth muscle at the treatment site by the material exchange between the pulmonary artery endothelium and the smooth muscle cells, responds to the high expression of nitroreductase, rapidly depolymerizes and releases the drug, and cooperatively improves the treatment effect of hypoxic pulmonary arterial hypertension, and can be applied in the preparation of hypoxic pulmonary arterial hypertension treatment drugs. The representative structural general formula is:

The invention belongs to the technical field of tumors, and particularly relates to an amino acid modified metal organic framework nano delivery system and a preparation method and application thereof, amino acid is one of L-histidine, L-tyrosine or 1-methyl-L tryptophan, a metal organic framework material is ZIF-8, and the metal organic framework material is a metal organic framework material. The preparation method comprises the following steps: respectively adding amino acid and a zinc salt solution into a 2-methylimidazole solution, carrying out a stirring reaction, and carrying out centrifugal washing so as to obtain the amino acid modified metal organic framework nano-delivery system, the amino acid modified metal organic framework nano-delivery system is applied to preparation of drugs for preventing or treating tumors, has good biocompatibility, and can be applied to preparation of drugs for preventing or treating tumors. The drug delivery system has the advantages of high targeting property, realization of drug release under low pH, good selectivity, good tumor inhibition effect, high safety, multifunctionality and diagnosis and treatment integration capability.

The present application relates to the field of radiopharmaceutical chemistry and clinical nuclear medicine technology, and particularly relates to a kind of compound targeted to FAP and its composition and application.The structure of the compound is as shown in the following formula (I).The compound can specifically respond to the enzyme highly expressed in tumor microenvironment, form active intermediate and covalently label adjacent protein, thereby prolonging the residence time of the compound of the present application at tumor target site, and improving imaging effect.After labeling with radionuclide, the obtained radioactive preparation has high uptake in tumor tissue, the tumor / non-target ratio is relatively optimal, and has good tumor uptake performance, and shows practical application prospect.(I).

This invention discloses a resource-optimized order execution system for high-frequency trading, comprising a signal receiving and parsing module, a decision and resource management engine, and an order instruction gateway. The system operates in a decision cycle of fixed duration T, maintaining a cycle number t that increments at the beginning of each cycle. The signal module starts in the t-th cycle, receiving and parsing the return rate and transaction probability prediction signals for that cycle. The decision unit judges the signals based on a preset threshold: if the return rate triggers a directional warning or there is a place to place an order that meets the probability threshold, it outputs an allow instruction signal; otherwise, it outputs a suppress instruction signal. When the resource scheduling unit receives the suppress signal, it immediately reallocates the resources of the order chain to the signal module. The order instruction gateway generates and sends a fixed number of orders only when it receives the allow signal; it disables the function when it receives the suppress signal. This system realizes dynamic optimization and collaborative scheduling of computing resources.

This invention belongs to the field of biotechnology, specifically relating to a nasal spray subunit vaccine for ovine infectious pleuropneumonia and its preparation method. It includes a first antigen protein and a second antigen protein, the amino acid sequence of which is shown in SEQ NO:1, and the amino acid sequence of which is shown in SEQ NO:2. The mass ratio of the first antigen protein to the second antigen protein is 1:(1-1.5). This invention [Ca²] + It can stabilize the structure of antigen proteins through ionic bonds, reducing their degradation in nasal mucosal secretions. Tannic acid and Ca²⁺ + When antigen complexes bind, they can form more ordered immunogenic complexes through the synergistic effect of polyphenols, metal ions, and proteins, making some antigens particulate and enhancing the uptake and processing efficiency of antigen-presenting cells. PDA can encapsulate the complex and use its biomimetic adhesion properties to form a firm attachment in the moist environment of the nasal mucosa, prolonging the antigen exposure time and promoting the continuous production of antibodies.

The invention relates to the technical field of radiopharmaceuticals and medical imaging, in particular to an STING-targeted precursor compound, a nuclide marker, a preparation method and application of the STING-targeted precursor compound, a nuclide marker, a pharmaceutical composition and application of the pharmaceutical composition. The STING targeting precursor compound, the pharmaceutically acceptable form of the STING targeting precursor compound, the nuclide marker of the STING targeting precursor compound and the pharmaceutically acceptable form of the STING targeting precursor compound have excellent in-vivo biological performance, can have high specific uptake in tumors or inflammations with high expression of interferon stimulating factors STING, has a high target-to-non-target ratio, and can be used for preparing the target-to-non-target tumor marker of the STING targeting precursor compound and the nuclide marker of the STING targeting precursor compound and the pharmaceutically acceptable form of the STING targeting precursor compound and the nuclide marker of the STING targeting precursor compound. And the non-specific background is low, and unnecessary radioactive injury can be reduced by lower non-target visceral organ uptake, so that the medication safety is high.