18results about How to "Relieve inflammation" patented technology

The present invention relates to the medical and food use of bile acid derivatives. Specifically, the present invention relates to the use of 3-oxoLCA in reducing oxidative stress and inflammation in pregnant mothers and their offspring. Specifically, the present invention relates to the use of 3-oxoLCA to reverse the effects of oxidative stress on pregnant mothers, in particular, to maintain fetal equal weight, significantly reduce placental and liver oxidative stress in pregnant mothers and the resulting inflammation or dysfunction of the placenta and liver, and to improve the intestinal flora imbalance of pregnant mothers. Further studies have found that 3-oxoLCA has long-term effects, in particular, can significantly reduce the effects of oxidative stress during pregnancy on oxidative stress and inflammation in the liver of offspring.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a sulfhydrylated hyaluronic acid drug-loaded hydrogel preparation and a preparation method and application thereof, and the preparation method comprises the following steps: preparing isorhamnetin nanocrystalline ISO-NCs by adopting an anti-solvent precipitation method; the preparation method comprises the following steps: constructing thiolated hyaluronic acid HA-SH responded by GSH; and uniformly embedding the ISO-NCs into the HA-SH hydrogel, so as to prepare the sulfhydrylated hyaluronic acid drug-loaded hydrogel preparation ISO-NCs-coated Gel, and preparing the sulfhydrylated hyaluronic acid drug-loaded hydrogel preparation ISO-NCs-coated Gel. The drug-loaded hydrogel preparation constructed by the invention can be used for targeted therapy of colon cancer.

This invention discloses a strain of *Lactococcus gasseri* LG3092 that produces the bacteriocin GarQ and effectively antagonizes multidrug-resistant *Helicobacter pylori*, and its applications. *Lactococcus gasseri* LG3092 was deposited at the Guangdong Provincial Microbial Culture Collection Center on October 30, 2023, with accession number GDMCC No: 63939. Studies have shown that LG3092 has the following beneficial effects: (1) it can produce the bacteriocin GarQ, effectively inhibiting the growth of *Helicobacter pylori* and other common pathogenic bacteria; (2) it has a high survival rate in the stomach, can colonize the stomach, and can compete with pathogenic bacteria for binding sites, effectively reducing the infection rate of *Helicobacter pylori* in the stomach; (3) it can improve the pathological state of the stomach and alleviate inflammation. Therefore, *Lactococcus gasseri* LG3092 has great application potential in the preparation of products for the prevention or treatment of *H. pylori*, especially multidrug-resistant *H. pylori* infection.

The utility model relates to the field of medical instruments, in particular to a disposable crissum postoperative nursing pad. The utility model provides a disposable crissum postoperative nursing pad which can inject water to perform hot compress or cold compress on a patient when the disposable crissum postoperative nursing pad is pasted for use, relieve inflammation, swelling and pain, reduce bleeding, improve use comfort and promote wound healing. A disposable crissum postoperative nursing pad comprises a breathable pad, a first sticking sheet and the like, and the upper side of the rear portion of the breathable pad is connected with the first sticking sheet. Cold water or hot water is poured into the water injection pipe and then enters the water bag for water injection, then the anti-overflow screw cover is rotated to be movably installed for sealing, then the device is pasted on trousers for use, hot compress or cold compress is carried out through hot water or cold water, and therefore when the device is pasted for use, water injection can be carried out on a patient for hot compress or cold compress. Inflammation, swelling and pain are relieved, bleeding is reduced, the use comfort is improved, and wound healing is promoted.

The invention belongs to the technical field of biomedicine, and particularly relates to a preparation method and application of baicalein supramolecular nanobelts.The baicalein supramolecular nanobelt for relieving intestinal injury of crisp tilapia mossambica is prepared according to the following steps that baicalein and dimethyl sulfoxide are mixed, then water is added for stirring, then centrifugal cleaning and dialysis are conducted with purified water, and the baicalein supramolecular nanobeltssambica is obtained; and freezing and drying to obtain the baicalein supermolecule nanobelt. The water solubility and bioavailability of the baicalein supramolecular nanobelt are remarkably improved, the crisp meat quality of tilapia can be kept, and intestinal inflammation can be relieved.

The utility model discloses an internal arteriovenous fistula internal diameter monitoring and protecting device which comprises a controller and a multifunctional cuff, and the controller is composed of a bandage, a hook-and-loop fastener, a plastic shell, a power button, a touch display screen, a charging interface, an air path interface, a circuit interface, a lithium battery, a single-chip microcomputer, an audio output module, a linear motor, a miniature air pump and a miniature electromagnetic valve. The multifunctional oversleeve is composed of an oversleeve body, a hook-and-loop fastener, an air channel connecting pipe, a circuit connecting pipe, an air bag, an MEMS ultrasonic patch, a flexible film temperature sensor and a graphene far infrared patch, and the circuit connecting pipe and the air channel connecting pipe of the multifunctional cuff are connected with a circuit interface and an air channel interface of the controller respectively. The pressure applied to the internal arteriovenous fistula is adjusted by detecting the inner diameter of the internal arteriovenous fistula, and meanwhile, the internal arteriovenous fistula is irradiated by infrared rays, so that the internal arteriovenous fistula can be monitored and maintained for a long time, and the formation of internal arteriovenous fistula aneurysm is prevented and treated.

This invention, entitled *Lactobacillus paracasei* HMU-02 and its application in the prevention and treatment of inflammatory bowel disease, belongs to the field of microbial technology. The technical problem to be solved is the lack of an effective probiotic for the prevention or treatment of inflammatory bowel disease in the existing technology. The key technical solution is the provision of *Lactobacillus paracasei* (… Lacticaseibacillus paracasei HMU-02, this strain was deposited at the China Center for Type Culture Collection on June 23, 2025, with accession number CCTCC NO: M20251386; the extracellular vesicles prepared by this strain have significant effects on the prevention and treatment of inflammatory bowel disease and have great potential in the application of products for the prevention and treatment of inflammatory bowel disease.

The invention discloses a lactobacillus paracasei CCFM1503 capable of inhibiting skin ceramide decomposition and relieving skin inflammation and a metagen thereof, and belongs to the technical field of microorganisms and medicines. The lactobacillus paracasei CCFM1503 provided by the invention can be used for effectively increasing the content of ceramide secreted by keratinocytes and effectively promoting the vitality of the keratinocytes in external application. The composition can inhibit the expression of ceramide decomposition related enzymes and relieve skin inflammation during oral administration, specifically, the expression of SMS and ASAH1 enzymes is inhibited, so that the abnormal decomposition of ceramide is inhibited; the compound can inhibit the expression of related proinflammatory factors (IL-1, IL-4 and TSLP), reduce the skin inflammation reaction caused by abnormal decomposition of skin ceramide and repair skin injury, has a certain application prospect in treatment of skin inflammation and injury caused by abnormal decomposition of ceramide, and is used for preparing external or oral medicines.

This invention provides a nanomaterial for relieving inflammation and pain in tendinopathy and its preparation method, relating to the field of biomedical technology. The nanomaterial comprises decellularized tendon DTM and hybrid membrane vesicles (MSM) of macrophages and nerve cells. The aforementioned nanomaterial for relieving inflammation and pain in tendinopathy includes decellularized tendon DTM and hybrid membrane vesicles (MSM) of macrophages and nerve cells. Combining these two components yields DTM-MSM, which regulates the proliferation and differentiation of tendon stem cells, modulates the local immune microenvironment, and relieves pain. It can improve inflammation and pain in tendinopathy and accelerate the repair of damaged tendons. In other words, DTM-MSM can not only alleviate the pathophysiological changes in tendinopathy but also rapidly improve the main clinical symptoms of tendinopathy, such as pain, swelling, and functional limitation, thus overcoming the current shortcomings of tendinopathy treatments, including slow onset of action, poor compliance, significant side effects, and unclear efficacy.

The application discloses an implant assembly and a preparation method thereof, relates to the technical field of stomatology, and discloses the implant assembly, which comprises a wear-resistant base and an anti-infection coating. The raw material components of the wear-resistant base comprise a matrix powder, an antibacterial powder and a wear-resistant additive. The anti-infection coating is arranged on at least part of the surface of the wear-resistant base, and the raw material components of the anti-infection coating comprise an organic matrix, a metallized porphyrin and an extracellular vesicle. The implant assembly provided by the application can effectively improve the success rate of implant surgery of a tooth patient, meets the long-term use requirement of the implant in an oral environment, and the raw materials used in the application are low in price, the preparation method is simple, and the application is easy to popularize.

This invention belongs to the fields of genetic engineering and microbial technology, and discloses a genetically engineered probiotic *E. coli* that produces indole-3-acetic acid and its applications. This invention uses wild-type *E. coli* Nissel 1917 as the host, and achieves this by knocking out its endogenous tryptophanase gene. tnaA The invention involves introducing a recombinant expression vector containing the tryptophan monooxygenase gene and the indoleacetamide hydrolase gene to obtain genetically engineered probiotic *E. coli*. The invention also describes the application of this genetically engineered probiotic in the microbial synthesis of indole-3-acetic acid (IAA) using tryptophan as a substrate; and its application in the preparation of drugs, probiotic preparations, or functional products for alleviating intestinal inflammation and / or maintaining intestinal barrier function. The genetically engineered probiotic *E. coli* constructed in this invention can stably and efficiently produce IAA and can be used to prepare drugs or products for alleviating intestinal inflammation and maintaining intestinal barrier function.

This invention relates to the field of biopharmaceutical technology, specifically to a BTO / PB acoustic pressure electrocatalytic nanoplatform ointment, its preparation method, and its application. The ointment is an injectable BTO / PB acoustic pressure electrocatalytic nanoplatform ointment formed by combining a barium titanate and Prussian blue composite nanomaterial with an ointment. The BTO / PB acoustic pressure electrocatalytic nanoplatform ointment of this invention exhibits excellent biocompatibility. Unlike traditional antibiotics, BTO / PB generates ROS (reactive oxygen species) through an ultrasound-driven catalytic reaction, independent of antibiotics, thus eliminating the risk of drug resistance. It effectively addresses the increasingly serious problem of antibiotic resistance, has a good antibacterial effect against periodontal pathogens, significantly alleviates gingival inflammation, reduces the infiltration of inflammatory cells, lowers the expression of inflammatory factors, and effectively inhibits osteoclast activity, thereby protecting alveolar bone and maintaining the integrity of periodontal tissues.

The invention discloses preparation and application of carbon quantum dots. The quantum dot is obtained by dissolving arginine, cobalt salt and organic acid in water, heating for reaction, taking supernatant, dialyzing and freeze-drying. The quantum dots can be used for preparing a hydrogel system, and the hydrogel system is obtained by compounding the cobalt-doped arginine carbon dots and ZIF-8 and then packaging the mixture and CaO2 in a double-crosslinking injectable hydrogel matrix. The method has a photothermal effect and multiple enzyme activity. In the early stage of infection, the weakly acidic microenvironment of the wound triggers CaO2 to be decomposed to generate H2O2, and carbon quantum dots are promoted to be released; under laser irradiation, the system synergistically generates local high heat, releases NO gas and catalyzes to generate hydroxyl radicals, so that photo-thermal / gas / chemical kinetics triple synergistic sterilization is realized. In a microenvironment at the later stage of inflammation, the enzyme activity of the system is converted into an anti-oxidation mode and cooperates with the release of tannic acid to regulate and control polarization of macrophages, so that the inflammation is effectively relieved. The invention provides an innovative integrated solution for the treatment of infectious wounds.

The invention discloses an application of intestinal Rosebaria capable of promoting intestinal bacteria to produce valeric acid and a composition of the intestinal Rosebaria in relieving ulcerative colitis, and belongs to the technical field of microorganisms. According to the intestinal Rosiberia NSP017 disclosed by the invention, the konjac glucomannan can be quickly utilized, and the composition of the intestinal Rosiberia and the konjac glucomannan can be used for improving the disease activity index and spleen enlargement of a mouse with ulcerative colitis, maintaining the integrity of an intestinal barrier, reducing the oxidative stress level, and improving the ulcerative colitis activity index and the spleen enlargement of the mouse with ulcerative colitis, so that the intestinal Rosiberia NSP017 can be used for treating ulcerative colitis. The level of a clinical diagnosis marker for colitis is remarkably reduced, the effect is superior to that of a clinical medicine mesalazine, and it is found that the intestinal Rosebawnella NSP017 can promote intestinal bacteria of mice with colitis to recover the capacity of producing valeric acid. The intestinal Rosibula sp. NSP017 and the composition of the intestinal Rosibula sp. NSP017 have very wide application prospects in the aspect of preparing foods, pharmaceutical compositions, health-care products or feed additives for relieving ulcerative colitis.

The present application provides a new strain of Agaricus blazei Murill, which is Agaricus blazei Murill JSR-1 with a preservation number of CGMCC No.23250. The present application also provides Agaricus blazei Murill polysaccharide extracted from fermentation liquor of Agaricus blazei Murill JSR-1. The Agaricus blazei Murill strain with the preservation number of CGMCC No.23250 provided by the present application has a short preparation period, a high extraction rate, an easy-to-implement preparation method, and can be mass-produced. The Agaricus blazei Murill polysaccharide obtained by the method of the present application is safe and has no side effects, can obviously improve the water content of the skin, relieve skin inflammation, and has good soothing and anti-wrinkle effects.

The invention discloses a traditional Chinese medicine composition for treating skin diseases and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicines. The composition comprises tripterygium wilfordii, fructus kochiae, angelica sinensis, radix angelicae, frankincense, myrrh, periostracum cicada, pearl and menthol. The external emulsifiable paste with the traditional Chinese medicine composition is prepared by decocting medicinal oil, preparing powdery medicine and preparing water extraction medicine. The composition disclosed by the invention has a good curative effect on eczema, urticaria, skin itch and the like. The traditional Chinese medicine has the effects of dispelling wind, nourishing blood, promoting blood circulation to remove blood stasis, moistening dryness and relieving itching.

The present application relates to the technical field of biological medicine, and particularly relates to siRNA targeting CD177 and application thereof in preparation of a medicine for treating NLRP3 gene mutation related diseases, the siRNA targeting CD177 can significantly reduce peripheral blood CD177 expression and significantly reduce CD177 mRNA expression in skin, liver and spleen; can significantly reduce the number of peripheral blood neutrophils and IL-6 and IL-1 beta positive cell proportion; can significantly reduce IL-6, IL-1 beta and TNF-alpha expression in tissues and serum. The siRNA targeting CD177 can effectively relieve NLRP3 mutation related multi-organ inflammation, and the effect is better than that of traditional anti-inflammatory treatment (such as IL-6 blocking or IL-1 beta neutralizing antibody), and is a very promising treatment strategy.

This invention belongs to the field of daily chemical products technology, specifically relating to a pure herbal hair growth and anti-hair loss shampoo based on multi-pathway synergistic effects and its preparation method. The herbal hair growth and anti-hair loss shampoo comprises: hair follicle regulating ingredients, blood circulation promoting ingredients, antibacterial and antipruritic ingredients, and natural surfactant ingredients. This invention scientifically proportions the above ingredients. The extract obtained from the hair follicle regulating ingredients regulates sebum secretion in hair follicles; the extract obtained from the blood circulation promoting ingredients promotes blood circulation in scalp capillaries; the extract obtained from the antibacterial and antipruritic ingredients inhibits scalp infections and hair follicle inflammation; and the surfactants give the shampoo good stability. This invention, through the multi-pathway synergistic effects of the above components, solves the shortcomings of existing herbal shampoo products, such as simple formulas, insufficient extraction of effective ingredients, reliance on chemical surfactants, and limited efficacy. It has the advantages of being natural, gentle, non-irritating, and having a high utilization rate of effective ingredients.