164results about How to "Relieve inflammation" patented technology

The invention relates to the field of microorganisms, in particular to bifidobacterium adolescentis YG3912, inactivated thalli, an extract, a culture, a culture supernatant, a fermentation product and / or a fermentation supernatant of the bifidobacterium adolescentis YG3912, an application of the bifidobacterium adolescentis YG3912 in preparation of a composition for promoting skin repair, reducing skin inflammation or allergy, improving skin quality and improving skin quality. The invention also relates to application of the composition in products for resisting skin aging and enhancing skin immune function. The bifidobacterium adolescentis YG3912 and the related products thereof have the advantages that the bifidobacterium adolescentis YG3912 and the related products of the bifidobacterium adolescentis YG3912 are high in skin cell repairing capacity, skin inflammation relieving, inhibiting or eliminating capacity and remarkable in skin aging resisting capacity, so that the bifidobacterium adolescentis YG3912 and the related products of the bifidobacterium adolescentis YG3912 are expected to be used for skin health care such as skin repairing, inflammation relieving and light aging resisting, and the bifidobacterium adolescentis YG3912 and the related products thereof have remarkable application value and market potential.

The invention relates to lactobacillus crispatus LC30 for preventing and treating female genital tract infection and application of the lactobacillus crispatus LC30. The lactobacillus crispatus LC30 is preserved in the China General Microbiological Culture Collection Center with the preservation number of CGMCC NO.31923. The lactobacillus crispatus LC30 has good hydrogen peroxide production capacity and adhesion capacity, has a strong inhibition effect on main vaginitis pathogenic bacteria, and can be used for preventing and treating female genital tract infection. The composition is effective to nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the pathogenic bacteria and prevent and treat drug resistance; besides, the fermentation product can reduce the content of pathogenic bacteria metabolites, regulate the secretion of cytokines and achieve the effect of relieving inflammation, so that the fermentation product can be used for preparing products for preventing and treating genital tract pathogenic bacteria infection, preventing and treating vaginitis and / or removing pudendum peculiar smell.

The invention relates to the technical field of biology, and discloses a stem cell exosome anti-hair loss and hair growth complex and a preparation method thereof.A hair growth agent is wrapped and loaded in adipose-derived mesenchymal stem cell exosome to form a drug-loaded stem cell exosome; the medicine-carrying stem cell exosome is loaded in cross-linked hydrogel composed of a gentisic acid-cyclodextrin complex and epsilon-polylysine modified hyaluronic acid to form the stem cell exosome anti-hair loss and hair growth complex, and the stem cell exosome anti-hair loss and hair growth complex is directly smeared and externally applied to the scalp surface and acts on the hair follicle infection part in a targeted mode, so that the hair loss prevention and hair growth promotion effect is achieved. The stem cell exosome anti-hair-loss and hair-growth-promoting compound can inhibit bacterial growth, relieve and treat hair follicle inflammation caused by bacterial infection and improve the scalp environment, so that under the condition that inflammation is effectively controlled, the drug-loaded stem cell exosome in the stem cell exosome anti-hair-loss and hair-growth-promoting compound is stably released, damaged hair follicle cells are repaired, hair regeneration is promoted, the exosome treatment effect is prolonged, and the anti-hair-loss and hair-growth-promoting effect is achieved. The purpose of treating alopecia is achieved.

The invention discloses a liver-targeting drug liposome and application thereof, and relates to the field of drug delivery, cholate and mannose are used for respectively modifying phospholipid molecules DSPE-PEG2000, two raw materials DSPE-PEG2000-CA and DSPE-PEG2000-MAN composed of the liposome are synthesized, and then the liposome is prepared into the liver-targeting drug liposome. The liposome with liver targeting property is obtained from the liposome, cholesterol, DSPC, DC-cholesterol and a water-soluble therapeutic drug according to a certain proportion, the liposome has relatively high cell safety and liver targeting property, and the therapeutic effect of the corresponding drug can be remarkably improved after the drug is embedded.

The invention belongs to the technical field of biological medicine, and relates to hydrogel for promoting wound healing and a preparation method and application thereof.The preparation method comprises the steps that firstly, coriander exosomes are extracted from coriander through a gradient centrifugation and sucrose density gradient method, then the coriander exosomes and a sodium alginate solution are mixed according to the mass-to-volume ratio of 0.5-2 mg: 1 mL, and a hydrogel solution is obtained; and mixing the exosome suspension with a calcium chloride solution according to a volume ratio of (0.5-2): 1, and carrying out crosslinking to obtain the coriander exosome-loaded hydrogel. The coriander exosome-loaded novel hydrogel provided by the invention has good viscoelasticity and biocompatibility, and can be applied to the surface of a skin wound as a dressing; meanwhile, the hydrogel has a coriander exosome slow-release effect, so that the exosome release time is prolonged, and the biological function is better played; by slowly releasing the coriander exosome, the hydrogel can relieve oxidative stress and inflammation of wounds and promote wound repair.

The invention discloses plant lactobacillus WH021 and application thereof in preventing and / or relieving neuroinflammation, and belongs to the technical field of microorganisms. The plant lactobacillus WH021 is separated and purified from excrement of healthy babies, is a probiotic with the function of relieving neuroinflammation, and has good application potential in development of food, health care products and drugs for preventing brain inflammation related diseases caused by chronic inflammation of bodies of middle-aged and elderly people.

The invention relates to the field of microorganisms, in particular to Akkermansia muciniphila YG2645 with an intestinal tract-immune-metabolic axis regulating function, an inactivated thallus, an extract, a culture, a culture supernatant, a fermentation product and / or a fermentation supernatant of the Akkermansia muciniphila YG2645, a composition containing the Akkermansia muciniphila YG2645 and a preparation method of the composition containing the Akkermansia muciniphila YG2645 and the composition containing the Akkermansia muciniphila YG2645 and the composition containing the composition. The invention also relates to application of the compound in preparation of products for preventing and / or treating inflammatory diseases. The Akkermansia muciniphila YG2645 and related products of the Akkermansia muciniphila YG2645 have the functions of regulating and controlling immune response, regulating and controlling metabolism, regulating intestinal flora and the like, and the Akkermansia muciniphila YG2645 and the related products of the Akkermansia muciniphila YG2645 have remarkable application value and market potential.

The invention discloses a cerium oxide-based nano material for bone defect repair and a preparation method of the cerium oxide-based nano material. The cerium oxide-based nano material for bone defect repair is prepared by performing surface modification on cerium oxide-based nano enzyme, and the surface modification comprises introducing a targeting ligand and / or carbon quantum dots into the cerium oxide-based nano enzyme. The invention also discloses a cerium oxide-based composite bone scaffold. The cerium oxide-based composite bone scaffold is prepared by compounding the cerium oxide-based nano-enzyme and / or the cerium oxide-based nano-material and the bone tissue engineering material.

The invention discloses a biologically safe and degradable cerium-based tannic acid nano-enzyme as well as a preparation method and application thereof. The nano-enzyme can be administrated through a non-invasive nasal cavity. In an area with excessive ROS, thioketone on CeTA-k1tkP is destroyed, PEG is removed, hydrogen bonds of an amino acid sequence are allowed to form beta-sheet, the beta-sheet is accumulated at an inflammation part, and a fiber or network structure is formed. Meanwhile, CeTA-k1tkP shows enzyme-like capacity, ROS is effectively eliminated, inflammation is effectively relieved, and systemic immunosuppression is avoided at the same time. In an influenza A (Flu A) virus or Sendai virus (SeV) mediated viral pneumonia model, CeTA-k1tkP can generate responsive deformation in inflammatory lung tissues, so that the nano-enzyme effectively decomposes ROS (reactive oxygen species). In addition, the CeTA-k1tkP can relieve bacterial inflammation and reduce tissue damage in a mouse viral pneumonia model with secondary bacterial infection.

The invention provides an anti-hair loss and anti-dandruff composition and a preparation method thereof, and belongs to the technical field of wash supplies. The anti-hair loss and anti-dandruff composition is prepared from the following raw materials: a plant raw material, a plant extract, a caffeine composition and an oil control composition, wherein the plant raw materials comprise the following raw materials in parts by mass: 5-20 parts of ginger root, 5-20 parts of black ginger root, 5-20 parts of alpinia japonica root, 1-3 parts of ligusticum wallichii, 5-10 parts of radix sophorae flavescentis, 2-4 parts of fructus cnidii, 1-5 parts of fructus viticis, 3-5 parts of saponin, 5-8 parts of soapberry peel, 1-5 parts of dandelion, 5-8 parts of polygonum multiflorum, 1-3 parts of mulberry, 3-6 parts of cacumen biotae, 3-6 parts of mulberry leaf, 7-10 parts of purslane and 1-4 parts of mangnolia officinalis; the plant extract is prepared from the following raw materials in parts by mass: 5 to 20 parts of aloe extract, 1 to 10 parts of herba menthae extract, 5 to 20 parts of fructus forsythiae fruit extract, 5 to 20 parts of tea leaf extract, 5 to 20 parts of herba centellae extract and 1 to 10 parts of cordyceps militaris extract. The composition prepared by the invention not only has good anti-dropping and anti-dandruff effects, but also has good stability.

The present invention relates to the application of glycyrrhizin drug-loaded nanoparticles for preparing drugs for treating psoriasis, and belongs to the technical field of nano traditional Chinese medicine. The multi-component drug includes baicalin, paeoniflorin, and liquiritin. Baicalin can regulate NF-κB and JAK / STAT signaling pathways, inhibit skin inflammatory reactions, and improve atopic dermatitis lesions; it can also relieve skin inflammation in psoriasis mice by inhibiting the IL-17 / IL-23 axis. Peony glycosides can regulate a variety of signaling pathways, including the GPCR pathway and the JAK2 / STAT3 pathway, etc., can significantly reduce the transcription level of STAT3, inhibit the secretion of cytokines by Th17 cells, and thus alleviate the symptoms of psoriasis. As one of the main active ingredients of licorice, liquiritin has a good therapeutic effect on acute lung injury, cancer, and cell damage caused by inflammation. The present invention utilizes glycyrrhizin nanoparticles to load the above-mentioned drugs, and the corresponding drug-loaded nanoparticles can be better absorbed by intestinal cells and inflammatory cells, and exert a good therapeutic effect on psoriasis.

The invention provides a high-activity probiotic food for pets, which is characterized by comprising the following components in parts by weight: 88-93 parts of animal meat source, 8-12 parts of boneless chicken powder, 8-12 parts of fish protein powder, 10-15 parts of potato powder, 3-6 parts of beer yeast powder, 3-6 parts of compound probiotics, 0.8-1.2 parts of metabiotics and 3-6 parts of semen plantaginis. Wherein the compound probiotics are prepared by mixing bacillus subtilis SCS-06, the preservation number of which is CCTCC (China Center for Type Culture Collection) NO: M20211498 and bacillus licheniformis XCL-09, the preservation number of which is CCTCC NO: M20211497. The prepared probiotic grain contains rich nutrient substances, probiotics and traditional Chinese medicine active ingredients, the content of active bacteria in the product is high, and the probiotic grain has a remarkable enhancing effect on digestion promoting ability and immunity of intestinal tracts and is effectively proliferated to continuously protect the intestinal tracts.

The invention discloses a head-mounted multispectral device capable of intelligently adjusting and improving sleep, and belongs to the technical field of sleep-aiding physiotherapy, the head-mounted multispectral device comprises two elastic sheets arranged on one side of a shell, a micro spectrometer arranged on one side of the shell, and a transmission unit arranged in the shell and matched with the two elastic sheets, the transmission unit is used for synchronously stretching and moving the two elastic sheets; the elastic support is arranged on one side of the shell, shading cloth is fixed in the elastic support, the shading cloth is used for shading the eyes of a user, an overturning unit matched with the elastic support is arranged on one side of the shell, and the overturning unit is used for adjusting the angle position of the shading cloth; the limiting piece is arranged on one side of the shell, the limiting piece is matched with the transmission unit, and the limiting piece is used for limiting the two elastic pieces; spectral infrared light is used for irradiating eyes, so that sleep quality can be improved, blood circulation can be promoted, immunity can be enhanced, and pain and inflammation can be relieved.

The present invention proposes a Chinese medicine composition for treating allergic rhinitis, and a preparation method and application thereof, which belong to the field of pharmaceutical technology. Ag-graphene oxide is adsorbed on in vitro proliferated γδT cells, a Chinese medicine fermentation product obtained by fermentation and extraction of Xanthium sibiricum, Astragalus, Poria, Magnolia officinalis, and Mentha is prepared, berberine and quercetin are prepared into eutectic powder, the three are mixed and added into water, probiotics, carboxymethyl chitosan, poloxamer 407 and poloxamer 188 are added, and mixed evenly to prepare a Chinese medicine composition for treating allergic rhinitis, which has a good effect of improving allergic rhinitis, adopts a method of combining traditional Chinese and Western medicine, reduces inflammatory response, enhances the immune function of patients, improves the clinical symptoms of patients with allergic rhinitis, reduces the long-term recurrence rate, reduces the use of drugs, improves the quality of life, and reduces the risk of developing asthma, and has broad application prospects.

The invention discloses a preparation method of compound polysaccharide microspheres capable of releasing NO. The preparation method comprises the following steps: cross-linking swallow polysaccharide with L-ARG, and preparing L-ARG-containing swallow polysaccharide hydrogel through a Mannich reaction; then loading EGCG (epigallocatechin gallate) onto the L-ARG-containing swallow polysaccharide hydrogel through a Schiff base reaction, and obtaining the compound polysaccharide microspheres capable of releasing NO by utilizing an emulsification method. The invention also discloses an application thereof. The hydrogel microsphere capable of targeting the colon is prepared, and the hydrogel microsphere can be accurately exploded at the colon part after being swallowed. A dextran sodium sulfate (DSS)-induced IBD mouse model is established to test the drug effect, and the result shows that the compound polysaccharide microspheres have a remarkable treatment effect on DSS-induced ulcerative colitis, can obviously improve the symptoms of ulcerative colitis, and provides a theoretical basis and a clinical basis for new drugs for clinically preventing and treating ulcerative colitis.

The invention relates to combined lactobacillus salivarius LS100 for inhibiting vaginitis pathogenic bacteria and preventing and treating vaginitis and application of the combined lactobacillus salivarius LS100. The combined lactobacillus salivarius LS100 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC NO.32135. The combined lactobacillus salivarius LS100 has good hydrogen peroxide production capacity and adhesion capacity, and can be used for preparing medicines for preventing and treating vaginitis. The traditional Chinese medicine composition has a relatively strong inhibition effect on main vaginitis pathogenic bacteria, is effective on nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the pathogenic bacteria and prevent generation of drug resistance; besides, the fermentation product can reduce the content of pathogenic bacteria metabolites, regulate the secretion of cell factors and play a role in relieving inflammation, so that the fermentation product can be used for preparing products for preventing and treating genital tract pathogenic bacteria infection and / or preventing and treating vaginitis.

The invention belongs to the field of small molecule compound medicines, and relates to application of an APE1 inhibitor in preparation of a medicine for treating asthma. The invention provides a novel treatment strategy of asthma, discovers a new target APE1 for treating asthma, realizes an effective treatment effect on asthma by using an APE1 inhibitor C10 compound, can remarkably inhibit the inflammatory cell activity such as mast cells, eosinophilic granulocytes and lymphocytes of asthma, and can remarkably inhibit the inflammatory cell activity of mice lung pathology observation. The C10 compound disclosed by the invention has obvious relieving and relieving effects on lung pathological changes of asthma mice, so that the C10 compound can be clinically used for preventing or treating asthma, and has the industrial advantages of small molecular weight and simple synthesis process.

The invention belongs to the field of small molecule compound medicines, and relates to application of an APE1 inhibitor in preparation of a medicine for treating nasosinusitis. The present application finds a new target APE1 for treating nasosinusitis, and achieves effective treatment of nasosinusitis by an APE1 inhibitor (including a C10 compound), in which the C10 compound shows a very excellent therapeutic effect, significantly inhibits pathological symptoms of nasosinusitis, including relieving Th2 inflammation, reducing eosinophilic granulocyte infiltration, improving nasal barrier integrity damage, and preventing or treating nasosinusitis. And the nasal mucosa neovascularization is prevented by inhibiting the generation of VEGF and other cell factors, and the inflammatory response of chronic nasosinusitis is effectively relieved. In addition, the C10 compound is simple in structure and easy to synthesize, has good patent medicine characteristics, and has good industrialization prospects.

The invention discloses a fermented caffeine eye cream composition. Comprising the following components in parts by weight: 30 to 80 parts of a fermentation composition, 1 to 5 parts of caffeine, 0.1 to 0.3 part of hydroxypropyl tetrahydropyrantriol, 0.5 to 2 parts of nicotinamide, 0.1 to 1 part of squalane, 0.01 to 0.5 part of a ceramide composition, 0.005 to 0.05 part of dipeptide diaminobutyryl benzyl amide diacetate, 0.005 to 0.05 part of a polypeptide composition, 0.01 to 0.5 part of carnosine, 0.01 to 0.5 part of tetrahydromethylpyrimidine carboxylic acid and 3 to 12 parts of a plant extract. The invention also discloses an eye cream containing the eye cream composition. The fermented caffeine eye cream composition provided by the invention can effectively smooth the skin surface, and is beneficial to preventing and comforting aging, improving skin elasticity, improving dark circles, relieving edema and removing under-eye puffiness.

The invention relates to a medicine balloon dilatation catheter and a using method thereof.The medicine balloon dilatation catheter comprises an inner tube, an outer tube, a balloon, medicine patches and a supporting mechanism, the supporting mechanism comprises a supporting piece and a push-pull piece which have an initial state and a supporting state, the supporting piece is provided with a plurality of supporting parts which are arranged corresponding to the medicine patches and located in the balloon, and the push-pull piece is arranged on the outer tube; when the supporting piece is in an initial state, the supporting part is straightened and is not in contact with the balloon; when the supporting piece is in the supporting state, the supporting part arches outwards and can jack up the medicine patch corresponding to the supporting part outwards. The supporting part on the supporting mechanism arches outwards and jacks up the medicine patch, on one hand, the medicine patch can be attached to the lesion blood vessel wall in advance, so that medicine is released in advance, and inflammation caused by blood vessel opening is relieved; on the other hand, part of the balloon wall is anchored on the blood vessel wall, so that the balloon is prevented from shifting in the expansion process, and the stability is better.

The pterocarpus santalinus extract or pterostilbene is applied to the dual effects of removing acnes and controlling oil. The invention provides a composition for removing acnes and / or controlling oil, wherein the composition comprises a pterocarpus santalinus extract and / or pterostilbene as an active ingredient for removing acnes and / or an active ingredient for controlling oil. The invention also provides application of the pterocarpus santalinus extract and / or pterostilbene in preparation of drugs, cosmetics or skin care products for removing acnes and / or controlling oil. The inventor finds that the pterocarpus santalinus extract and / or pterostilbene serving as a single active component can achieve multiple effects, and the pterocarpus santalinus extract and / or pterostilbene show potential application prospects in the field of modern skin care products with simplified skin care and natural multiple effects.

The invention discloses a probiotic / mucoprotein loaded oral microsphere system as well as a preparation method and application thereof, and belongs to the field of compositions. The preparation method of the system comprises the following steps: dissolving probiotics, Mucin and HAMA in double distilled water containing phenyl lithium phosphate LAP and calcium chloride to prepare a gel matrix solution; adding the dissolved gel matrix liquid into an oil phase solvent, and stirring at a high speed in a container; after uniformly stirring, carrying out an ultraviolet light crosslinking reaction, and after the reaction is finished, fully cleaning the obtained microspheres to remove the redundant oil phase solution, so as to obtain microspheres; and dispersing the obtained microspheres in a sodium alginate solution under an acidic condition, uniformly mixing, carrying out a cross-linking reaction, and filtering and cleaning after the reaction is finished, so as to obtain the probiotic / mucoprotein loaded oral microspheres. According to the invention, HAMA and SA are utilized to prepare an oral microsphere system resistant to gastric acid to co-deliver Mucin and EcN, so as to realize continuous and effective regulation and control of unbalanced intestinal flora by probiotics.

The invention relates to combined lactobacillus salivarius LS360 for preventing and / or improving female genital tract infection and application of the combined lactobacillus salivarius LS360. The combined lactobacillus salivarius LS360 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC NO.32134, and the combined lactobacillus salivarius LS360 has good biological characteristics and endurance capacity and can be used for preventing and / or improving female genital tract infection. The traditional Chinese medicine composition has a relatively strong inhibition effect on main vaginitis pathogenic bacteria, is effective on nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the nutritional pathogenic bacteria and prevent and treat drug resistance; besides, the bacterial strain and the fermentation product can also reduce the content of pathogenic bacteria metabolites, regulate the secretion of cell factors and play a role in relieving inflammation, so that the bacterial strain and the fermentation product can be used for preparing products for preventing and treating female genital tract pathogenic bacteria infection, preventing and treating vaginitis and / or removing pudendum peculiar smell.

The invention discloses a method for entrapping a silymarin and escin composition by a low-energy method and application of the silymarin and escin composition in anti-allergic and anti-inflammatory products. The method comprises the following steps: mixing silymarin, escin and a solvent, heating and stirring until the silymarin, escin and the solvent are dissolved, adding an emulsifier, slowly dropwise adding grease, finally adding the balance of water, and cooling. The invention provides a method for preparing a stable and transparent nano-emulsion by comprehensively utilizing a phase composition method and a phase transformation method without the aid of strong shearing effects such as high-pressure homogenization, ultrasound or microjet and the like, and provides a method for preparing the stable and transparent nano-emulsion by applying a pharmaceutical preparation to wounds of patients and facilitating efficient and mild relieving of inflammation and discomfort.

The invention relates to the technical field of gouty arthritis, and discloses a traditional Chinese medicine plaster for treating gouty arthritis and a preparation method thereof. The ointment comprises the following materials: 1 part of paniculate swallowwort root, 1 part of asarum, 1 part of borneol, 2 parts of costustoot, 2 parts of earthworm, 3 parts of ligusticum wallichii, 3 parts of radix clematidis, 3 parts of spina gleditsiae, 4 parts of raw rhubarb, 6 parts of mint, a proper amount of vaseline, a proper amount of sesame oil, a medical dressing plaster and a desensitization adhesive tape. According to the traditional Chinese medicine plaster for treating the gouty arthritis and the preparation method of the traditional Chinese medicine plaster, the traditional Chinese medicine plaster directly acts on an affected part, transdermal absorption is achieved, the local treatment effect can be rapidly achieved, pains and inflammations caused by the gouty arthritis are relieved, medicinal materials are smashed into ultra-micro powder of 300 meshes through an ultra-micro powder machine, and the traditional Chinese medicine plaster is prepared into the traditional Chinese medicine plaster for treating the gouty arthritis. Compared with an oral medicine, the external plaster can increase the surface area of the medicine and improve the permeability and absorption efficiency of the medicine, and compared with the oral medicine, the external plaster can reduce the stimulation of the medicine to gastrointestinal tracts and systemic side effects.

The invention discloses a fiber membrane for promoting healing of infected wounds and a preparation method and application thereof. The fiber membrane comprises a plurality of non-randomly arranged spinning nanofibers, and is prepared from a material comprising poly-L-lactic acid through electrostatic spinning. The porous microstructure of the fiber membrane provides a suitable microenvironment for cell migration and epithelial regeneration, and can promote healing of bacterial infected wounds. Through verification, the fiber membrane disclosed by the invention can effectively promote wound healing through ways of antibiosis, inflammation relief, collagen regeneration, angiogenesis and the like. In addition, through ultrasonic enhanced treatment, the antibacterial and tissue repairing functions can be exerted to the maximum extent under the condition that external medicine is not added, and the application prospect is wide.

The utility model discloses a multifunctional stone needle massage instrument which comprises a body, a scraping massage part, an essential oil smearing part and an electrical part, and the electrical part is provided with a battery and a circuit board. The scraping massage part is provided with a scraping plate which is used for performing scraping operation on external skin; the essential oil smearing part is provided with an essential oil bottle, the essential oil bottle is fixedly connected to the interior of the body in a replaceable mode, and a liquid outlet is formed in one end of the essential oil bottle and used for smearing a solution in the essential oil bottle on the external skin. In conclusion, the device can be used for scraping therapy and massage and can also be used for smearing essential oil. And through the heating assembly, the vibration assembly and the treatment chip, the scraping massage effect can be improved. The absorption effect of the essential oil medicine can be enhanced through infrared light, and the skin of a user can be smeared more hygienically and safely through the replaceable essential oil bottle. In addition, a machine body of the whole massage instrument is round and smooth and is easy to hold, the scraping therapy plate is easy to fit skin, and the massage effect and massage enthusiasm of people can be remarkably improved.

The invention relates to a degradable double-enzyme active nano-enzyme for treating diabetic foot ulcer, and aims to provide a novel efficient treatment scheme. The nano-enzyme has peroxidase-like and catalase-like dual-enzyme activity, is prepared by a specific chemical synthesis method, has good biodegradability, and can efficiently catalyze a reaction in a physiological environment to reduce drug resistance. Compared with a traditional treatment method, the nano-enzyme disclosed by the invention can be used for remarkably improving the treatment effect of the diabetic foot ulcer, accelerating the healing process and reducing the toxic and side effects on a human body and the manufacturing cost at the same time, and a safer and more effective treatment choice is provided for a patient with the diabetic foot ulcer.

The application discloses a whitening and freckle-removing composition containing white tomato and chases yellow grass, a preparation method and application thereof, and belongs to the technical field of food, wherein the whitening and freckle-removing composition is composed of white tomato powder and chases yellow grass powder with a weight ratio of 1-3:2-7. The preparation method comprises the following steps: (1) beating, separating, concentrating and drying white tomatoes to obtain white tomato powder; (2) soaking chases yellow grass in acidic water, performing solid-liquid separation, concentrating and drying the obtained clear liquid to obtain chases yellow grass powder; and (3) mixing the white tomato powder and the chases yellow grass powder. The application utilizes the combination of white tomatoes and chases yellow grass, and improves the preparation process of chases yellow grass, so that the two components produce a synergistic effect in inhibiting tyrosinase activity and inhibiting melanin production.

The present invention relates to the medical and food use of bile acid derivatives. Specifically, the present invention relates to the use of 3-oxoLCA in reducing oxidative stress and inflammation in pregnant mothers and their offspring. Specifically, the present invention relates to the use of 3-oxoLCA to reverse the effects of oxidative stress on pregnant mothers, in particular, to maintain fetal equal weight, significantly reduce placental and liver oxidative stress in pregnant mothers and the resulting inflammation or dysfunction of the placenta and liver, and to improve the intestinal flora imbalance of pregnant mothers. Further studies have found that 3-oxoLCA has long-term effects, in particular, can significantly reduce the effects of oxidative stress during pregnancy on oxidative stress and inflammation in the liver of offspring.