Anti-inflammatory, anti-bacterial and absorbable medical suture and preparation method thereof

A suture and solution technology, applied in the field of medical suture, can solve the problems of skin tissue inflammation, wound bacterial infection, etc., to increase mechanical strength and cell affinity, increase antibacterial and anti-inflammatory properties, and increase mechanical properties Effect

Active Publication Date: 2015-11-18
安徽省康宁医疗用品有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a foreign body, the suture exists in the incision tissue, and it is easy to cause inflammation in the skin tissue. The sutured wound is easily infecte

Method used

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  • Anti-inflammatory, anti-bacterial and absorbable medical suture and preparation method thereof

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preparation example Construction

[0032] refer to figure 1 , the preparation method of a kind of anti-inflammatory and antibacterial absorbable medical suture that the present invention proposes, comprises the steps:

[0033] S1. Preparation of suture fiber: Mix carboxymethyl chitosan, polylactic acid, grass carp bone collagen, pigskin collagen, formaldehyde starch, and maltose, heat up to 70-90°C, and stir at a speed of 300-400r / min for 1 -2h, extrude with a twin-screw extruder, water-cooled, air-dried, and pelletized to obtain masterbatches; heat up to 140-160°C to melt the masterbatch, defoam, and obtain primary fibers through a spinneret; primary fibers at 40- Stretching in a water bath at 60°C to obtain suture fibers;

[0034] S2. Prepare a coating solution: add the coating to 40-50 parts of water, heat up to 50-70° C., and stir at a speed of 400-600 r / min for 4-6 hours to obtain a coating solution;

[0035] S3. Coating weaving: coating the suture fiber obtained in S1 with the coating solution obtained ...

Embodiment 1

[0038] An anti-inflammatory and antibacterial absorbable medical suture, its raw materials include by weight: 80 parts of carboxymethyl chitosan, 20 parts of polylactic acid, 10 parts of grass carp bone collagen, 12 parts of pig skin collagen, 4 parts of formaldehyde starch, 4 parts maltose, 1 part paint;

[0039] Among them, the preparation method of the coating is as follows: add chitosan to water, disperse evenly by ultrasonic, add fumaric acid and mix well, add perchloric acid dropwise, heat up to 70°C, keep stirring for 5 hours, and obtain solution A; use NaHCO 3The solution adjusts the pH of solution A to 8, adds it dropwise into acetone, filters, washes twice with ethanol, filters, adds ethanol, Soxhlet extraction for 60 hours, and vacuum-dries to obtain modified chitosan, wherein, chitosan and water The weight to volume ratio (g / ml) of chitosan and fumaric acid is 1:60, the weight to volume ratio of chitosan to fumaric acid is 1.7:5.5, and the weight to volume (g / ml) r...

Embodiment 2

[0045] An anti-inflammatory and antibacterial absorbable medical suture, its raw materials include by weight: 100 parts of carboxymethyl chitosan, 10 parts of polylactic acid, 15 parts of grass carp bone collagen, 8 parts of pig skin collagen, 6 parts of formaldehyde starch, 2 parts maltose, 5 parts paint;

[0046] Among them, the preparation method of the coating is: adding chitosan to water, ultrasonically dispersing evenly, adding fumaric acid and mixing, adding perchloric acid dropwise, raising the temperature to 50°C, and stirring for 7 hours to obtain solution A; using NaHCO 3 The solution was adjusted to pH=6 of solution A, added dropwise to acetone, filtered, washed 4 times with ethanol, filtered, added with ethanol, extracted by Soxhlet for 48 hours, and dried in vacuum to obtain modified chitosan, wherein chitosan and water The weight-to-volume ratio (g / ml) of chitosan and fumaric acid is 1:80, the weight-to-volume ratio (g / ml) of chitosan to perchloric acid is 1.7:5...

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Abstract

The invention discloses an anti-inflammatory, anti-bacterial and absorbable medical suture comprising raw materials in parts by weight as follows: 80-100 parts of carboxymethyl chitosan, 10-20 parts of polyactic acid, 10-15 parts of grass carp bone collagen, 8-12 parts of pig skin collagen, 4-6 parts of aldehyde starch, 2-4 parts of maltose and 1-5 parts of a coating. The invention further discloses a preparation method of the anti-inflammatory, antibacterial and absorbable medical suture. The method comprises steps as follows: S1, preparing suture fibers; S2, preparing a coating solution; S3, performing coating treatment and knitting. The suture is good in anti-inflammatory and antibacterial performance, well compatible with biological tissue, good in mechanical performance and simple to operate, cells can adhere and reproduce on the suture easily, and industrial production is facilitated.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to an anti-inflammatory and antibacterial absorbable medical sutures and a preparation method thereof. Background technique [0002] Surgical suture refers to a special thread used for wound ligation, suture hemostasis and tissue suture in surgical operations. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. Absorbable sutures include natural fibers and synthetic polymer sutures. [0003] Polylactic acid (PLA) sutures are synthetic polymer sutures. The degradation rate of PLA fibers is slow and the mechanical properties are strong. However, PLA is hydrophobic, and cells cannot adhere and reproduce well on the fibers. Biodegradation The lactic acid produced can easily cause inflammation. [0004] Chitosan is a natural fiber suture with good biocompatibility, antibacterial ability, chemical inertness, and...

Claims

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Application Information

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IPC IPC(8): A61L17/12A61L17/08A61L17/10A61L17/14D01F8/18D01F8/14D01F1/10
Inventor 祁建兵
Owner 安徽省康宁医疗用品有限公司
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