26 results about "Fumaric acid" patented technology

This invention belongs to the technical field of medicinal chemistry, specifically relating to a novel crystal form of cariprazine, specifically the cariprazine-4-hydroxybenzoic acid-methanol-hemihydrate crystal form and its preparation method. The novel cariprazine-fumaric acid crystal form provided by this invention comprises a basic unit of one molecule of cariprazine, one molecule of 4-hydroxybenzoic acid, one molecule of methanol, and 0.5 molecules of water. Its preparation method is simple to operate, the crystallization process is easy to control, and it has good reproducibility. The formation of a eutectic significantly enhances the solubility of cariprazine, exhibiting strong pharmaceutical value.

This application relates to the field of feed processing technology and discloses a highly absorbable feed composition for nursery pigs containing compound probiotics. The composition includes the following ingredients: a basal diet, a live bacteria compound powder composed of freeze-dried *Lactobacillus plantarum* powder and freeze-dried *Bacillus coagulans* powder, medium-chain triglycerides, a PIT-responsive compound emulsifier composed of polysorbate-80 and sorbitan monooleate, anhydrous trehalose, glycerol, a micron-sized confinement carrier, which is a porous carrier obtained by high-temperature expansion and vacuum degassing of perlite powder, and fumaric acid. This invention employs anhydrous trehalose and glycerol to construct a high-permeability system, combined with medium-chain triglycerides and a compound emulsifier to form an oil-phase encapsulation, achieving the technical effect of effectively blocking external moisture penetration and improving the heat resistance of the bacteria.

The present disclosure encompasses solid state forms of Lucerastat, in embodiments crystalline Lucerastat: L-Pyroglutamic acid, crystalline Lucerastat: Salicylic acid, crystalline Lucerastat: Fumaric acid, crystalline Lucerastat: Benzoic acid and crystalline Lucerastat: o-Acetylsalicylic acid, solid state form thereof, processes for preparation thereof, and pharmaceutical compositions thereof.

The application belongs to the field of co-crystals and provides a 2-amino-4,6-dimethylpyrimidine-fumaric acid co-crystal material, the 2-amino-4,6-dimethylpyrimidine-fumaric acid co-crystal material is a colorless transparent crystal prepared by dissolving 2-amino-4,6-dimethylpyrimidine and fumaric acid in an organic solvent and then using a crystallization method, and the pyrimidine-organic acid co-crystal material has fluorescence performance. The co-crystal material has good fluorescence performance, especially under light with a wavelength of 365 nm, presents light yellow fluorescence, and is expected to be applied in the fields of fluorescence detection and optoelectronic devices.

The application discloses application of bio-organic acid in preparation of plasmid conjugation transfer inhibitor and / or antibacterial drugs. The bio-organic acid in the application includes one or more of citric acid, fumaric acid or alpha-ketoglutaric acid. The application finds the possibility of the bio-organic acid as the conjugation transfer inhibitor in preventing and controlling the spread of antibiotic resistance level through in-vivo and in-vitro conjugation tests. The application provides the use of the bio-organic acid as the conjugation transfer inhibitor, limits the conjugation transfer of various clinical drug-resistant plasmids, and is one of strategies for solving the problem of bacterial drug resistance.

The present disclosure relates to a microorganism of the genus Corynebacterium in which the activity of fumarate hydratase is enhanced, and a method for producing L-amino acids using same. The microorganism of the genus Corynebacterium with enhanced fumarate hydratase exhibits increased production capability of L-amino acids such as L-arginine, L-citrulline, L-ornithine, O-acetylhomoserine, L-homoserine, and L-histidine, compared to a parent strain in which the fumarate hydratase is not enhanced, and the microorganism with enhanced fumarate hydratase can be widely used for the production of L-amino acids.

This invention belongs to the field of pharmaceutical technology and relates to a method for preparing vonoprazan fumarate. Compound 3 reacts with a methylamine alcohol solution and a reducing agent at low temperature, followed by quenching, and then forms a salt with fumaric acid to generate vonoprazan fumarate. In this method, the amination-reduction step is performed under mild conditions, and the product can be directly obtained by salt formation with fumaric acid after simple post-treatment following quenching, without the need for pre-preparing other intermediate salts. This method is simple to operate, low in cost, and yields a product with few impurities, making it suitable for industrial production.

This invention relates to a method for synthesizing S,S-EDDS using EDDS lyase catalysis, belonging to the field of enzyme catalysis technology. To address the problems of limited enzyme variety and poor activity in existing enzymes, this invention provides a method for synthesizing S,S-EDDS using EDDS lyase catalysis. The method is characterized by using fumaric acid and ethylenediamine as substrates, and conducting a catalytic reaction to generate S,S-EDDS under the catalysis of EDDS lyase. The EDDS lyase is selected from the amino acid sequences shown in SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 5, SEQ ID NO. 7, SEQ ID NO. 9, or SEQ ID NO. 10. This invention exhibits high enzyme catalytic activity and can effectively catalyze the generation of the desired (S,S)-ethylenediaminedisuccinate.

The application discloses a cerium-iron heterometallic organic framework material and a preparation method and application thereof, and relates to the technical field of MOF materials, and specifically discloses a cerium-iron heterometallic organic framework material, a preparation method and application thereof.The cerium-iron heterometallic organic framework material comprises a sheet-shaped Ce MOF and a nanoparticle-shaped Fe MOF loaded on the sheet-shaped Ce MOF, and is a MOF on MOF structure.The preparation method comprises the following steps: adding an organic metal salt and fumaric acid into an organic solvent, uniformly stirring and mixing, and then continuously stirring to obtain a mixed solution; transferring the mixed solution into a sealed container to perform a heating reaction; carboxylate ions ionized from the organic metal salt control the coordination rate of Fe and Ce ions and fumaric acid, so that the Ce MOF is first generated, and then the granular Fe MOF is in-situ grown on the surface of the Ce MOF to obtain a reaction product; and cooling, separating, washing and drying the reaction product to obtain the cerium-iron heterometallic organic framework material.The cerium-iron heterometallic organic framework material prepared by the application can adsorb fluoride ions through surface complexation, electrostatic adsorption, ligand exchange and ion exchange, and has excellent fluoride ion adsorption performance.

This invention discloses a chitosan-organic acid supramolecular ionic salt and its preparation method, belonging to the supramolecular field. The invention involves mixing chitosan with an organic acid (one or more of maleic acid, sorbic acid, ferulic acid, caffeic acid, cinnamic acid, and fumaric acid) and a solvent, followed by drying to obtain the chitosan-organic acid supramolecular ionic salt. The chitosan-organic acid supramolecular ionic salt prepared by this invention can improve the water solubility of chitosan and improve severely damaged hair, offering multiple functions such as repair and smoothing, making it suitable for hair care products. Furthermore, the preparation method is simple, requiring no catalyst or high temperature and pressure, making it suitable for industrial use.

This invention relates to the field of environmental pollution control and functional materials technology, and discloses an LDH@MIL-Fe core-shell composite material, its preparation method, and its application. The LDH@MIL-Fe core-shell composite material uses LDH as the core and MIL-Fe as the shell; the general formula of LDH is [M... 2+ 1‑x M 3+ x (OH)2] x+ (A n‑ ) x / n •mH2O; the MIL-Fe is Fe 3+ The MIL-Fe core serves as the metal center, and its organic ligands are one or more of terephthalic acid, trimesic acid, 2-aminoterephthalic acid, and fumaric acid. This invention constructs an LDH@MIL-Fe core-shell composite material, forming a heterogeneous structure with LDH as the core and MIL-Fe as the shell, achieving interfacial synergistic effects between LDH and MIL-Fe. Through the synergistic effect of photocatalysis and persulfate activation, it achieves highly efficient degradation of organic pollutants and exhibits good stability and recyclability. Even after multiple cycles, the material maintains a high degradation efficiency.

The application provides a CO2 capture method and a CO2 capture device coupled with electrochemical regeneration of hydrogen. The method comprises the following steps: absorbing CO2 in a CO2-containing gas by using an alkaline solution to form a CO2-rich solution; performing acid-base neutralization of the CO2-rich solution and an acidic solution to obtain a neutralization solution and CO2; performing electrolysis of the neutralization solution to obtain a cathode electrolysis product and an anode electrolysis product, wherein the cathode electrolysis product is H2 and the alkaline solution, and the anode electrolysis product is O2 and the acidic solution; and the acidic solution is selected from one or a combination of more than two of the following solutions: pyruvic acid solution, gluconic acid solution, malonic acid solution, tartaric acid solution, glyceric acid solution, oxalacetic acid solution, formic acid solution, isopropionic acid solution, isobutyric acid solution, fumaric acid solution, aconitic acid solution, isocitric acid solution and hexanediol diacid solution. The acidic solution generated by electrolysis can avoid corrosion of the device equipment and reduce the net energy consumption and net cost of the CO2 capture process.

The application discloses a preparation method of active lactobacillus and application of the active lactobacillus in livestock and poultry feed, and comprises the following steps: S1, inoculating a strain; S2, fermentation culture; and S3, preparing active lactobacillus powder; the application significantly improves the production efficiency and product stability of the active lactobacillus by optimizing the culture medium formula and fermentation process parameters; the soybean meal hydrolysate and corn starch hydrolysis sugar are used as a composite carbon and nitrogen source, and the polysorbate 80 is used to improve the surface permeability of the bacterial body, so that the lactobacillus plantarum can rapidly proliferate in a low-cost culture medium, and a foundation is laid for efficient synthesis of bacteriocin; fumaric acid is used to inhibit the activity of lactate dehydrogenase, metabolic flow is directed to the bacteriocin synthesis path, the accumulation amount of lactic acid is effectively reduced, and the feedback inhibition of the acid metabolite on the bacterial body is avoided; the prepared active lactobacillus powder has excellent thermal stability, and realizes long-acting stability of the antibacterial effect of the feed.

The invention discloses a preparation method of a coordination polymer containing CuII and research on the inhibition effect of the coordination polymer on soil urease and nitrifying bacteria, and relates to the technical field of fertilizer.The preparation method comprises the steps that 3-aminopyridine and fumaric acid serve as raw materials to synthesize N1, N4-bis (3-pyridyl)-2-butenamide, then CuCl2. 2H2O and the synthesized N1, N4-bis (3-pyridyl)-2-butenamide are used for preparing the coordination polymer containing CuII. The novel coordination polymer [Cu (3-bbpa) (5-HIPA). H2O] is synthesized from N, N, N, N ', N'-bis (3-pyridyl)-2-butenamide and 5-hydroxyisophthalic acid by a hydrothermal method, and the crystal structure of the novel coordination polymer [Cu (3-bbpa) (5-HIPA). H2O] is analyzed to research the influence of the novel coordination polymer as an inhibitor on soil urease and nitrifying bacteria. The difunctional inhibitor is studied to delay the conversion process of urea from urea nitrogen to ammonium nitrogen and ammonium nitrogen to nitrate nitrogen, overcomes the defect of single inhibition capability of a traditional inhibitor, is strong in inhibition capability, low in toxicity, low in cost and simple in synthesis method, can effectively improve the utilization rate and stability of the fertilizer urea, and has a wide application prospect. Nitrogen loss in agricultural activities is reduced, the fertilization cost is reduced, and the grain yield is increased.

The application discloses a multi-component effervescent tablet with natural eutectic solvent as components and separation effect on protein. The hydrogen bond donor of the natural eutectic solvent is glycerol, and the hydrogen bond acceptor includes mogroside or stevioside; the carbon dioxide source of the effervescent tablet is sodium carbonate or sodium bicarbonate, and the acid source is citric acid, tartaric acid or fumaric acid. The above natural components are mixed and heated to form the natural eutectic solvent with effervescence, which is then added to the raw powder of the effervescent tablet composed of the carbon dioxide source and the acid source, and the multi-component effervescent tablet loaded with the natural eutectic solvent is obtained by using the pressurization method. The process is simple, fast and low in cost, and is convenient for realizing large-scale production; the prepared effervescent tablet has ideal properties and hardness, small tablet weight difference, and obvious effect in enriching trace protein in the extract of snake slough. The application not only expands the existing use of the eutectic solvent, but also provides a new choice for the separation and enrichment of biological macromolecules.

The application provides a donepezil hydrochloride orally disintegrating tablet pharmaceutical composition and a preparation method thereof, and belongs to the technical field of medicines.The technical scheme of the application is as follows: a donepezil hydrochloride composition, characterized in that the composition contains donepezil hydrochloride 6.25%, porous silicon carrier 2-6%, fumaric acid 1-3%, sodium carboxymethyl cellulose 0.7%, mannitol 53.05-79.05%, soluble starch 10-30%, and sodium stearyl fumarate 1%.The application provides a donepezil hydrochloride orally disintegrating tablet prescription process which is fast in disintegration, good in taste, high in safety, and feasible in large-scale production, is more suitable for the oral cavity characteristics of the elderly, and improves the compliance of patients in taking medicine.

The present application relates to the technical field of cell engineering, and particularly relates to a culture medium for producing biological antibodies and a fermentation method thereof.The culture medium comprises a basic culture medium and a fermentation culture medium; the basic culture medium is based on a commercial culture medium and comprises the following components: fumaric acid, ferric ammonium citrate, astragaloside and baicalein; the fermentation culture medium is based on a commercial culture medium and comprises the following components: L-citrulline, L-ornithine, L-theanine, L-homoarginine, L-hydroxyproline, L-allo-threonine, mannose, isorhamnetin and ginkgolin.The culture medium combination can effectively improve the expression level of target antibodies, supports cells to maintain long-term activity in a high-density state; meanwhile, the charge variant distribution of the obtained antibodies is more uniform, and the product purity and consistency are significantly improved.

This invention belongs to the field of pharmaceutical content detection, specifically relating to a method for determining the content of vonoprazan fumarate tablets. The vonoprazan fumarate tablets of this invention are prepared using mannitol, fumaric acid, croscarmellose sodium, hydroxypropyl cellulose, microcrystalline cellulose, and magnesium stearate as excipients. The preparation method described in this invention simplifies the preparation process and reduces production costs. This invention also provides the above-mentioned method for determining the content of vonoprazan fumarate tablets. High-performance liquid chromatography (HPLC) is used to accurately determine the content of the active ingredient vonoprazan in the prepared vonoprazan fumarate tablets. This method effectively eliminates the influence of added excipients and impurities on the determination of the active ingredient vonoprazan content, providing important assurance for clinical medication safety and offering a new method for the quality control of vonoprazan fumarate tablets.

This invention discloses a method for the continuous production of vonoprazan fumarate, relating to the field of chemical material preparation technology. The method includes the following steps: Step 1: Preparation of solution A; preparation of solution B; preparation of solution C; mixing solutions A, B, and C in a tubular reactor, collecting the effluent, pumping the effluent into a centrifugal extractor for centrifugation, and collecting the heavy phase; Step 2: Using a fully automated hydrogenation reactor with a fixed-bed palladium-on-carbon catalyst, mixing the heavy phase obtained in Step 1, hydrogen gas, and monomethylamine gas, collecting the effluent; Step 3: Adding fumaric acid to the effluent obtained in Step 2, stirring to induce crystallization, filtering, and drying to obtain vonoprazan fumarate. This invention, through a continuous reaction process, can shorten the reaction time, reduce the reaction concentration, thereby reducing the risk of the reaction, reducing the generation of by-product impurities, and thus improving the product yield and quality.

The application discloses an organic amine supramolecular ionic salt, a preparation method and application thereof in hair care, and belongs to the technical field of supramolecules. The organic amine supramolecular ionic salt is prepared by mixing organic amine (one of tetrahydroxypropyl ethylenediamine, triethylene glycol diamine and polyether amine) and organic acid (one or two of maleic acid, sorbic acid, ferulic acid, coffee acid, cinnamic acid and fumaric acid). The organic amine supramolecular ionic salt prepared by the application can repair disulfide bonds in hair from the structure, so that the hair is repaired and smooth.

A resin composition comprising (A) an unsaturated polyester oligomer, (B) a free radical polymerizable monomer, and (C) a photopolymerization initiator, wherein (A) the unsaturated polyester oligomer comprises a structure derived from a polyol component (a1) comprising 55 to 85 mol% neopentyl glycol relative to 100 mol% of the total polyol component, a structure derived from a polyacid component (a2) comprising isophthalic acid and / or terephthalic acid, and a structure derived from an unsaturated diacid component (a3) ​​comprising maleic anhydride and / or fumaric acid, wherein relative to 100 mol of the structure derived from the polyol component (a1), the structure derived from the polyacid component (a2) comprises 30 to 60 mol of the structure derived from the polyacid component (a2) and the structure derived from the unsaturated diacid component (a3) ​​comprises 40 to 70 mol of the structure derived from the unsaturated diacid component (a3).

The application relates to a high-stability anti-aging PVC color master batch and application thereof in automobile interior decoration, and the components of the high-stability anti-aging PVC color master batch include PVC resin, ABS resin, modified fumed silica, modified rare earth salt, pigment and additive; wherein the modified fumed silica is obtained by the following steps: firstly, reacting pentaerythritol and fumaric acid to obtain a modifier; secondly, reacting hydroxylated fumed silica and KH570 to obtain an intermediate product; and finally, reacting the modifier and the intermediate product; the modified rare earth salt is obtained by reacting pentaerythritol, fumaric acid and lanthanum acetate. The modified fumed silica limits the migration of VOC, improves the compatibility of components, in addition, the fumed silica has a porous structure, can adsorb VOC, and reduces the migration and volatilization of VOC. The modified rare earth salt can also limit the migration of VOC, improve the compatibility of components, inhibit the continuous and rapid degradation of PVC, and improve the stability.

This invention belongs to the field of pharmaceutical chemistry and crystallization technology, specifically disclosing a clonidine-fumaric acid cocrystal, its preparation method, and its application. The molar ratio of clonidine to fumaric acid is 1:2. This invention achieves precise control of clonidine's solubility and long-lasting sustained release by combining clonidine and fumaric acid in a 1:2 molar ratio to form a cocrystal, without altering the pharmacological activity of clonidine. Furthermore, the preparation method is simple and suitable for industrial production.

This invention relates to a composite methane inhibitor, sustained-release methane-inhibiting microparticles, their preparation method, and applications. The active ingredient of the composite methane inhibitor includes lauric acid monoglyceride and a composite additive, wherein the composite additive includes at least two of malic acid, fumaric acid, and tea saponin. This invention is the first to combine lauric acid monoglyceride, malic acid, fumaric acid, and tea saponin to prepare a composite methane inhibitor. It exhibits excellent methane emission inhibition by utilizing the synergistic effect between the components, and effectively avoids the adaptive evolution of rumen microorganisms to a single inhibitor through multi-target regulation. Furthermore, it uses safe and conventional raw materials, has low production costs, and possesses broad prospects for industrial application and research significance.

The application discloses a kind of molecular sieve-aluminum fumarate metal MOF composite adsorbing material for rotary dehumidification and preparation method thereof, comprising: first, preparing aluminum fumarate MOF powder;Second step, molecular sieve, the aluminum fumarate MOF powder, silica sol, water and organic binder are uniformly mixed to form composite slurry;By prefabricated aluminum fumarate MOF powder again composite slurry is made, avoid aluminum fumarate MOF particle migration, local enrichment and structure uneven, the steps of preparing aluminum fumarate MOF powder are as follows: first, fumaric acid is dissolved in water with sodium hydroxide to form a homogeneous solution;Second step, then the solution is added to aluminum sulfate solution;Third step, under the condition of 50~70 ℃, reaction 0.5~2h;Fourth step, after reaction, the obtained solid is dried at 80~120 ℃ for 6~12h, then ground, to obtain aluminum fumarate MOF powder with particle size of 1~10 μm.

The object of the present invention concerns a hair restructuring association comprising or alternatively consisting of: (a) a quaternary ammonium salt of formula (I) and (b) at least one sulpho-derivative of vegetable fatty acids, wherein R5, R6 are independently chosen between hydrogen and a radical R0, R0 consists of the following structure of formula (II), R1 is chosen from the group consisting of: hydrogen, methyl, isopropyl, sec-butyl, isobutyl, ethylenemethylthio, benzyl, para-hydroxybenzyl and 3-methylene-1H-indole, R2, R3, R4 are independently chosen from the group consisting of: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl and tert-butyl, mX− is chosen from the group consisting of: formic acid, acetic acid, unsaturated monocarboxylic acids, adipic acid, aldaric acid, oxalic acid, phthalic acid, azelaic acid, sebacic acid, malonic acid, succinic acid, tartaric acid, glutaric acid, pimelic acid, maleic acid, malic acid, fumaric acid and suberic acid, isocitric acid, citric acid, fatty acids, acidic amino acids, keto acids and aromatic carboxylic acids, m is an integer number comprised between 1 and 22, n is comprised between 2 and 20.