980results about How to "Improve action" patented technology

The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

Improved approaches for users to with graphical user interfaces of computing devices are disclosed. A rotational user action supplied by a user via a user input device can provide accelerated scrolling. The accelerated nature of the scrolling enables users to scroll or traverse a lengthy data set (e.g., list of items) faster and with greater ease. The amount of acceleration provided can be performed in successive stages, and / or performed based on the speed of the rotational user action. In one embodiment, the rotational user action is transformed into linear action with respect to a graphical user interface. The resulting acceleration effect causes the linear action to be enhanced such that a lengthy data set is able to be rapidly traversed.

A display system includes a continuous flexible display, and two main display supports, hingeable with respect to each other and each structurally configured to support a respective portion of the flexible display. The two main display supports are rotatable in opposite directions connected to each other by a respective hinge of a hinge mechanism. The main display supports are rotatable between a configuration for fixing the flexible display in a closed storage position and a planar configuration for fixing the flexible display in an open position. The two main display supports are coupled with each other by a movement synchronizing coupling enabling during movement between the closed and open position a mutual substantially synchronized rotating of the main display supports at substantially equal but opposite angles.

The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

Improved approaches for users to with graphical user interfaces of computing devices are disclosed. A rotational user action supplied by a user via a user input device can provide accelerated scrolling. The accelerated nature of the scrolling enables users to scroll or traverse a lengthy data set (e.g., list of items) faster and with greater ease. The amount of acceleration provided can be performed in successive stages, and / or performed based on the speed of the rotational user action. In one embodiment, the rotational user action is transformed into linear action with respect to a graphical user interface. The resulting acceleration effect causes the linear action to be enhanced such that a lengthy data set is able to be rapidly traversed.

The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.

The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.

The invention features compositions, methods, and kits for the treatment of metabolic disorders such as diabetes and obesity.

PCT No. PCT / GB98 / 02840 Sec. 371 Date Jul. 14, 1999 Sec. 102(e) Date Jul. 14, 1999 PCT Filed Sep. 18, 1998 PCT Pub. No. WO99 / 13741 PCT Pub. Date Mar. 25, 1999Food is rendered sterile by UV irradiation, preferably with UV at 265+ / -15 nm. A sterilization unit may include UV sources (90, 100, 110, 120) and a heat source, which may be a broad band UV source, a source of IR or microwave radiation. A combined microwave / UV unit can be used to defrost frozen food and simultaneously sterilize it or maintain sterility. Heating prior to UV irradiation can enhance the sterilization, as can rapid cooling after irradiation. Irradiation can also be enhanced by displacing the food during irradiation e.g. by supporting it on a rotatable support (135) and / or by displacing it relative to the support surface.

The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.

Provided are composition and / or methods useful in preventing onset and / or recurrence of cardiovascular events, especially in patients who have escaped the unstable period after cardiovascular angioplasty or in hyperlipidemia patients who have been treated with HMG-CoA RI.

The present invention provides pharmaceutical agents comprising a dipeptidyl peptidase IV (DPPIV) inhibitor and a biguanide agent in combination, which enhance the effects of active circulating glucagon-like peptide-1 (GLP-1) and / or active circulating glucagon-like peptide-2 (GLP-2).

Pharmaceutical compositions and methods for using are provided for restoring β-cell mass and function in a mammal in need thereof. The pharmaceutical compositions have a biological response modifier and a β-cell growth factor in admixture with a pharmaceutically acceptable carrier, adjuvant or vehicle.

A planar light source comprises at least one point light source disposed on a supporting substrate, and a cylindrical lens that covers the light emitting observation side of the point light source, wherein the cylindrical lens has a concave lens function in the direction (y direction) perpendicular to the supporting substrate, and has a convex lens function in at least part of the horizontal direction (x direction).

The present invention provides substituted bicyclic heteroaryl compounds, including, for example, 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines that modulate the activity of kinases and are useful in the treatment of diseases related to activity of kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

Pre-surgical planning for cranial and facial reconstruction includes preparing a computer generated jaw or skull model for determining a locational position for a dental implant, a surgical bone implant to repair missing bone in the cranium, install ear prostheses, and / or install nose prostheses. The computer generated jaw or skull model is made from medical imagery and computer aided design. A surgical guide is prepared with oversize holes in registration with analogs for the dental or surgical bone implants to be inserted at the locational positions determined by a dentist or surgeon in the jaw or cranial skull model. The surgical guide is fitted atop each analog, and the surgical guide is bonded to the jaw or skull model at a predetermined angle of the analog in the jaw or skull. The surgical guide is removed from the model attached to the law or skull of a patient for accurate drilling during the dental or surgical procedure for insertion of the implants into the jaw or skull of the patient.

A method of selecting components for use in water-absorbing pressure-sensitive adhesive compositions is provided. The method involves selecting a film-forming polymer, a ladder-like non-covalent crosslinker that is capable of forming a ladder-like interpolymer complex with the film-forming polymer selected, and selecting a carcass-like non-covalent crosslinker that is capable of forming a carcass-like complex with at least one of the film-forming polymer selected or the ladder-like non-covalent crosslinker selected. The adhesive hydrogels provide high adhesion in a swollen state and bridge the gap between conventional pressure sensitive adhesives and bioadhesives. Methods for preparing and using the resulting compositions are also disclosed.

A planar light source comprises at least one point light source disposed on a supporting substrate, and a cylindrical lens that covers the light emitting observation side of the point light source, wherein the cylindrical lens has a concave lens function in the direction (y direction) perpendicular to the supporting substrate, and has a convex lens function in at least part of the horizontal direction (x direction).

This invention relates to methods for treating a patient suffering from neuropathic or nociceptive pain which may be mechanical, visceral, and / or inflammatory in nature, comprising administering a therapeutically effective amount of Ranolazine to a patient in need thereof.

The present invention provides a hemostatic porous sponge comprising a matrix of a fibrous biomaterial and particles of a fluid absorbing, particulate material adhered to said matrix material, a method of producing these sponges and their use for wound healing.

A hoof boot has a base, a heel captivator, and a pivoting mechanism that disposes the heel captivator to pivot relative to the base, preferably in a manner that allows the heel captivator at least three degrees of freedom of movement relative to the base. The heel captivator is preferably low in the rearmost portion, which provides clearance for the pastern bones of the equine lower leg to descend upon weight bearing during movement at various gaits. To reduce the possibility for bruising and chaffing of soft tissue around the pastern bones, and to help eliminate accumulation of debris, preferred heel captivators have an open mesh architecture. Heel captivators can alternatively or additionally be designed with fabric covered neoprene or other liners. Boots are preferably tightened using mechanically advantages laces.

The present invention relates to liposome, mixtures or liposomes and liposomal compositions comprising at least two different adjuvants and a therapeutic agent, their production and use for the prevention and therapy of proliferative diseases, infectious diseases, vascular diseases, rheumatoid diseases, inflammatory diseases, immune diseases, in particular autoimmune diseases and allergies.

Methods for pharyngeal and cerebral cooling by delivering an ice slurry, slush or super-cooled gel to a patient's nasal cavity, oral cavity and / or throat are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. The cooling assembly includes a flexible balloon defining a chamber and a first elongate tubular member having a lumen in fluid communication with the chamber. A ice slurry having a temperature between about −5° C. and about 5° C. is delivered through the lumen of the first elongate tubular member into the chamber, wherein the flexible balloon expands to place it in contact with the nasal cavity. In another method, an expandable member is inserted through the patient's oral cavity and positioned such that when expanded it forms a low pressure seal substantially isolating the nasal and oral cavities from the patient's trachea. An ice slurry is delivered directly to the patient's nasal cavity.

An oral hygiene implement includes a cleaning element carrier and a body. The body has a proximal end and a distal end. The cleaning element carrier has a first area and a second area wherein the second area is disposed inboard of the first area. The first area is attached to the body while the second area is unattached to the body. A bending element is disposed between the first area and the second area, thereby allowing the second area to bend / flex while the first area stays fixed to the body.

A display system includes a continuous flexible display, and two main display supports, hingeable with respect to each other and each structurally configured to support a respective portion of the flexible display. The two main display supports are rotatable in opposite directions connected to each other by a respective hinge of a hinge mechanism. The main display supports are rotatable between a configuration for fixing the flexible display in a closed storage position and a planar configuration for fixing the flexible display in an open position. The two main display supports are coupled with each other by a movement synchronizing coupling enabling during movement between the closed and open position a mutual substantially synchronized rotating of the main display supports at substantially equal but opposite angles.

The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.