975 results about "Active compound" patented technology

The invention belongs to the field of pesticide preparations, and particularly relates to an oil suspending agent containing pleuromutilin and a preparation method of the oil suspending agent. According to the invention, by optimizing the formula, the obtained oil suspending agent can effectively prevent and treat bacterial diseases, the dosage form of the oil suspending agent is more beneficial to application to spraying method pesticide application, and the embodiment verifies that the prevention and treatment effect on the bacterial diseases can reach 90% or above under the condition that the concentration of pleuromutilin is 200PPM. In addition, according to a traditional method, an active compound is obtained through fermentation, and then the active compound is mixed with a corresponding solvent and an auxiliary agent to be processed into a dosage form, so that the cost is high, and great pollution is brought. The method provided by the invention not only meets the control requirements on bacterial diseases, but also saves the energy and power cost from the aspect of process, reduces the use of solvents, is more beneficial to environmental protection, and thus has great economic benefits, environmental benefits and ecological benefits.

The present invention relates to the field of biotechnology and medicine, in particular to a monoclonal antibody or antigen-binding fragment thereof that specifically binds to TNF-like ligand 1A (TL1A). The invention further relates to nucleic acids encoding said antibody, expression vectors, host cells and methods for producing same, methods for producing the antibodies according to the invention, pharmaceutical compositions comprising the antibody or antigen-binding fragment thereof according to the invention, as well as to pharmaceutical compositions comprising the antibody or antigen-binding fragment thereof according to the invention and other therapeutically active compounds; to methods for treating TL1A-mediated diseases or disorders, to use of the antibody or antigen-binding fragment thereof or pharmaceutical composition thereof for treating TL1A-mediated diseases or disorders, and to use of the antibody or antigen-binding fragment thereof according to the invention and other therapeutically active compounds for treating TL1A-mediated diseases or disorders.

The present invention relates to novel lignin-derived compounds and compositions comprising the same and their use as redox flow battery electrolytes. The invention further provides a method for preparing said compounds and compositions as well as a redox flow battery comprising said compounds and compositions. Additionally, an assembly for carrying out the inventive method is provided.

Compounds useful as biologically active compounds are disclosed. The compounds have the following structure (I) or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, L, L1, L2, L3, L4, L5, L6, M, m, and p are as defined herein. Methods associated with preparation and use of such compounds is also provided.

The present invention is the use of a small group of purine nucleotide phosphoramidate disclosed herein or a pharmaceutically acceptable salt thereof in an effective amount for the treatment or prevention of the novel 2019 coronavirus disease (COVID-19) in a host, for example a human, in need thereof.

Compounds useful as biologically active compounds are disclosed. The compounds have the following structure (I):or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, L, L1, L2, L3, L4, M and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

Compounds useful as biologically active compounds are disclosed. The compounds have the following structure (I):or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, L, L1, L2, L3, L4, M, q, w and n are as defined herein. Methods associated with preparation and use of such compounds is also provided.

The present invention relates to fungicidal mixtures comprising at least one substituted pyridine (compound I) and at least one active compound II in a weight ratio of from 100: 1 to 1: 100; to a method for controlling phytopathogenic harmful fungi using a mixture of at least one compound I and at least one compound II in a weight ratio of 100: 1 to 1: 100; to the use of a mixture comprising compound I and compound II for controlling phytopathogenic harmful fungi; to agrochemical compositions comprising these mixtures; and to agrochemical compositions further comprising seeds.

The invention relates to the technical field of substance detection and analysis, in particular to a method for identifying lactone odor active compounds in milk. According to the method for identifying the lactone odor active compounds in the milk, provided by the invention, the pretreatment of the milk sample is performed by combining the thin-film solid-phase microextraction with the sequential stirring rod adsorption method, and the gas chromatography-sniffing-mass spectrometry technology is matched, so that the sniffing detection rate of the lactone odor active compounds in the milk is remarkably increased; the method has the advantages of high efficiency, strong operability, environmental protection and the like, and has important application value in milk lactone odor active compound detection and milk flavor evaluation.

The invention relates to a method for producing microparticles comprising at least one organic active compound encapsulated by a shell of an organic wall material, the method comprising i. Providing a water-immiscible liquid containing the organic active compound to be encapsulated and at least one first shell-forming compound (SFC1); ii. Emulsifying the water-immiscible liquid obtained in step i. In an aqueous medium to obtain an oil-in-water (o / w) emulsion of the water-immiscible liquid in the aqueous medium; iii. Adding at least one second shell-forming compound (SFC2) to the aqueous medium or to the emulsion obtained in step ii. Prior to or during performing step ii., thereby obtaining an aqueous suspension of the microparticles; wherein the first shell-forming compound (SFC1) or the second shell-forming compound (SFC2) has 1, 2, 3, 4, 5 or 6, in particular 1, 2, 3 or 4, in particular 1, 2 or 3 first reactive groups (RG1) selected from isocyanate groups, isothiocyanate groups, carbonyl halide groups and carboxylic anhydride groups, per molecule, and the other shell-forming compound has 1, 2, 3, 4, 5 or 6, in particular 1, 2, 3 or 4, per molecule, in particular 1, 2 or 3 second reactive groups (RG2) selected from the group consisting of hydroxyl, thiol and primary amino groups, the first shell-forming compound (SFC1) or the second shell-forming compound (SFC2) having only one reactive group and the other shell-forming compound having 1, 2, 3, 4, 5 or 6, in particular 1, 2, 3 or 4, in particular 1, 2 or 3 reactive groups. The invention also relates to microparticles obtainable by this process and to the use thereof.

The present invention relates to fungicidal mixtures comprising at least one substituted pyridine (compound I) and at least one active compound II in a weight ratio of from 100: 1 to 1: 100; to a method for controlling phytopathogenic harmful fungi using a mixture of at least one compound I and at least one compound II in a weight ratio of 100: 1 to 1: 100; to the use of a mixture comprising compound I and compound II for controlling phytopathogenic harmful fungi; to agrochemical compositions comprising these mixtures; and to agrochemical compositions further comprising seeds.

The invention relates to the field of biotechnology and medicine, in particular to a monoclonal antibody specifically bound with BCMA or an antigen binding fragment of the monoclonal antibody. The invention also relates to nucleic acids encoding said antibodies, expression vectors, host cells and methods for producing the same, methods for producing antibodies according to the invention, pharmaceutical compositions comprising antibodies according to the invention, pharmaceutical compositions comprising antibodies according to the invention and other therapeutically active compounds, methods for treating BCMA-mediated diseases or disorders, and methods for treating BCMA-mediated diseases or disorders. The use of said antibodies or pharmaceutical compositions thereof for the treatment of BCMA-mediated diseases or disorders, and the use of said antibodies and other therapeutically active compounds for the treatment of BCMA-mediated diseases or disorders.

Disclosed are novel pharmaceutical, animal feed compositions and methods of treating non-human animals comprising at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s), or mixtures thereof, derived from non-woody plants of the genus Hesperaloe. Animal feed compositions may comprise a basal animal feed and water soluble solids extracted from Hesperaloe and comprising at least one saponin. The water soluble solids may comprise from about 5 to about 30 wt % saponin. The compositions of the present invention can be used for the treatment of non-human animals, such as poultry and more particularly for preventing and treating coccidiosis. An embodiment provides an immunological composition useful for inducing the production of antibodies to an antigen in a non-human animal comprising an antigen, preferably a coccidia, and a saponin composition extracted from Hesperaloe. The saponins extracted from Hesperaloe biomass may comprise 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside C, furcreastatin and yuccaloiside C.

The invention discloses a virtual drug screening method and system based on adaptation during testing. The method comprises the following steps that a historical data set of protein pocket-small molecule pairing is collected; constructing a double-encoder framework consisting of a protein pocket encoder and a small molecule encoder; performing joint training on the double-encoder architecture based on the historical data set to obtain a small molecule screening model; and obtaining protein pocket data, and screening and sequencing the candidate small molecules corresponding to the protein pocket data based on the small molecule screening model to obtain corresponding active compounds. According to the method, the adaptation technology during testing is introduced into the virtual drug screening task for the first time, structural specificity dynamic adaptation of the model to an unknown sample is achieved on the premise of not depending on a test label, and the generalization performance is remarkably improved.

The utility model discloses a rake type vacuum drying machine for diflufenican active compound production, which comprises a drying cylinder, a frame is arranged in the drying cylinder, fins are arranged on the inner side of the frame, guide grooves are arranged on two sides of the frame, a blanking cylinder is arranged at the bottom end of the drying cylinder, an auger shaft is arranged in the blanking cylinder, and the auger shaft is connected with the drying cylinder. And a discharging motor for driving the auger shaft to rotate is arranged on the outer side of the discharging barrel. According to the material drying device, the defects in the prior art are overcome, through the arrangement of the packing auger, dried materials can be rapidly guided out and collected in a centralized mode, the material drying efficiency is improved, and the material drying device has high social use value and application prospects.

The present disclosure generally relates to catalysts having an electron withdrawing group for use in a polyurethane formulation. The polyurethane formulation includes the catalyst having an electron withdrawing group, a compound containing an isocyanate functional group, an active hydrogen-containing compound, a halogenated olefin and optionally one or more of an amine catalyst having at least one tertiary amine group, a non-amine catalyst and an additive.

Solid lipid nanoparticles (SLNs) for delivery of bioactive compounds are disclosed. The SLNs comprise a lipid matrix and surfactant layer encapsulating at least one bioactive compound selected from vitamins, minerals, enzymes, algae-derived bioactives, proteins, peptides, amino acids, antioxidants, small synthetic molecules, plant-derived volatile compounds, or botanical extracts. The SLNs exhibit submicron particle size, low polydispersity, and sufficient surface charge to ensure colloidal stability and efficient delivery. In one embodiment, algae-based bioactives, such as phycocyanin or fucoxanthin, are encapsulated using only natural and sustainable lipids and surfactants to improve bioavailability and support environmentally friendly formulations. The SLNs may be formulated for oral, topical, transdermal, injectable, ophthalmic, mucosal, textile, veterinary, or agricultural administration. Applications include human and animal health, functional foods, skincare, nutrient supplementation, and crop treatment. The disclosed SLNs offer a biocompatible and scalable delivery system that protects sensitive compounds, enables sustained release, and enhances absorption across diverse industries.

The invention provides a method for extracting polyphenol from persimmon peel and application, the method comprises the steps of persimmon peel pretreatment, irradiation treatment, subcritical ethanol extraction and extraction of polyphenol in different forms, and the method belongs to the technical field of natural product extraction methods. According to the method, electron beam irradiation is utilized to treat persimmon peels, high energy in electron beams can bombard components such as cellulose and lignin in cell walls of the persimmon peels, tightly-combined chemical bonds are broken, ethanol in a subcritical extraction technology can permeate into the persimmon peels to extract polyphenol substances, and therefore the extraction efficiency of polyphenol is improved; and the consumption of the solvent in the extraction process can be reduced. Different forms of polyphenols are further extracted on the basis of the persimmon peel polyphenol crude extract, the polyphenol has good antioxidant capacity and alpha-glucosidase inhibitory activity, bioactive compounds in persimmon peel can be efficiently recycled, and future waste utilization and development of natural antioxidants are promoted.

The present invention relates to a pentacyclic active compound and a conjugate thereof and a use thereof. The compound and the conjugate have excellent tumor cell inhibition activity, stability and in vivo efficacy in animals.

The invention discloses 5-chloro-5-phenyl-4, 5-dihydroisoxazole-3-carboxylic acid and a derivative thereof (formula I): # imgabs0 #, and in the formula I, R is selected from H, C1-C6 alkyl and C3-C8 cycloalkyl, preferably H, methyl, ethyl, propyl, isopropyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. When the compound shown in the formula I is used for synthesizing related active compounds, the synthesis route can be greatly shortened, the yield is increased, and the application prospect is wide.

The invention discloses marine-derived penicillium as well as a fermentation method and application thereof. The marine source penicillium is named as Penicillium sp.DSF059, and the preservation number of the marine source penicillium is CCTCC (China Center For Type Culture Collection) NO: M 20232310. According to the invention, the culture conditions of the strain are optimized, the culture medium and culture conditions with high yield of antibacterial active compounds are selected for fermentation, more target products can be obtained, the operation is simple, the cost is low, and the method is suitable for industrial production. Meanwhile, the marine-derived penicillium sp. DSF059 can provide an excellent strain for the development of new drugs for resisting plant pathogens such as coffee leaf blight, coffee brown spot, grape gray mold, golden cypress brown spot, citrus black rot, phytophthora capsici, hickory leaf blight and coffee black spot as well as four pathogens separated from coffee leaf diseases and staphylococcus aureus; good application prospects are realized on prevention and treatment of phytopathogen and staphylococcus aureus.

The present invention relates to compositions comprising phospholipids for delivery of bioactive compounds such as ethyl esters, fish oil concentrates, cannabinoids, CoQ10 and curcumin under conditions such the bioavailability of the bioactive compounds is enhanced.

The invention provides a novel organic selenium compound and a synthesis method thereof, and application of the compound in preparation of drugs for preventing and / or treating cancers. According to the organic selenium compound provided by the invention, the natural active compound and the selenium element are combined, so that the anticancer activities of the natural active compound and the selenium element generate a synergistic effect, the safety and the anticancer effect of the organic selenium compound are improved, and the organic selenium compound has huge potential in the aspects of preventing and treating cancers. # imgabs0 #

The invention is directed to a biodegradable, thermoplastic multiblock copolymer, to a process for preparing a biodegradable, thermoplastic multiblock copolymer, to the use of a biodegradable thermoplastic multiblock copolymer, to a composition for the delivery of at least one pharmacologically active compound to a host, and a medical device comprising a biodegradable, thermoplastic multiblock copolymer. The biodegradable, thermoplastic multiblock copolymers of the invention comprise at least one prepolymer (A) segment and at least one hydrolysable amorphous prepolymer (B) segment, wherein the segments are linked by a multifunctional chain extender, wherein the at least one prepolymer (A) segment comprises: a) one or more hydrolysable linkages, b) a water-soluble polyoxazoline-based polymer, and c) reaction products of one or more cyclic monomers and / or one or more non-cyclic monomers, wherein the water-soluble polyoxazoline-based polymer is a polymer containing a repeating unit of structure −[N(COR1)CH2CH2]n− where R1 is independently selected for each repeating unit from an alkyl group and n is 3-100, and wherein the multiblock copolymer is amorphous.

The invention relates to the field of demulsifiers, in particular to an oil sludge demulsifier as well as a preparation method and application thereof. The oil sludge demulsifier comprises the following components in parts by mass: 20-35 parts of a surface active compound, 7-12 parts of a sodium alkyl sulfate cosolvent, 0.6-1.8 parts of a stabilizer and 48-55 parts of water, wherein the surface active compound comprises hyperbranched polyamidoamine and polyether amine modified magnetic nanoparticles. According to the oil sludge demulsifier, the problems that most of existing demulsifiers are small in dehydration amount, low in dehydration speed, poor in demulsification effect and low in treated oil content are solved, the demulsification performance of the oil sludge demulsifier is improved, the demulsification and dehydration efficiency is improved, and effective separation of oil sludge is achieved.

The present invention relates to a group of cannabinoid derivatives as pharmaceutically active compounds and methods of preparation thereof. The cannabinoid derivatives of the invention are analogues of cannabidiol (CBD). CBD is a non-psychoactive cannabinoid which has been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of the cannabinoid derivatives of the invention

The present invention relates to fungicidal compositions comprising 5-fluoro-4-imino-3-methyl-1-(p- tolylsulfonyl)pyrimidin-2-one (compound I) and at least one active compounds II. The invention also relates to an agrochemical composition comprising the composition and a solvent of solid carrier. Further, the invention relates to a non-therapeutic use of the inventive compositions controlling phytopathogenic harmful fungi.

The invention discloses a preparation method of a peony seed shell flavone extract, which comprises the following steps: extracting peony seed shell flavone (ZKHT) by adopting enzymolysis-ultrasonic extraction, and separating and purifying by using a resin adsorption combined membrane separation technology, so that various flavonoid active compounds such as kaempferol, luteolin and apigenin with high content in peony seed shells can be effectively extracted at the same time; the method provided by the invention provides technical support for reutilization of the peony seed shell waste, and realizes efficient and comprehensive utilization of the peony seeds and by-products thereof.

The invention belongs to the technical field of pesticide preparations, and relates to a preparation method and application of prothioconazole sustained-release microspheres. The preparation method comprises the following steps: adding an active compound, an emulsifier, isocyanate and polycaprolactone polyol into cyclohexanone, and uniformly mixing to obtain an oil phase; adding a dispersing agent into water and uniformly mixing to obtain a water phase; and adding dibutyltin dilaurate into the oil phase, reacting, mixing with the water phase, shearing, and stirring to obtain the prothioconazole sustained-release microsphere suspending agent. The prothioconazole sustained-release microsphere prepared by the process still keeps higher bactericidal activity on the premise of good leaf surface stability, so that reduction of the pesticide application frequency, improvement of the pesticide utilization rate and long-acting prevention and control of prothioconazole in the field are expected to be realized, and the prothioconazole sustained-release microsphere conforms to the national double reduction policy and is suitable for large-scale popularization and application.