300 results about "Active compound" patented technology

Disclosed are novel pharmaceutical, animal feed compositions and methods of treating non-human animals comprising at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s), or mixtures thereof, derived from non-woody plants of the genus Hesperaloe. Animal feed compositions may comprise a basal animal feed and water soluble solids extracted from Hesperaloe and comprising at least one saponin. The water soluble solids may comprise from about 5 to about 30 wt % saponin. The compositions of the present invention can be used for the treatment of non-human animals, such as poultry and more particularly for preventing and treating coccidiosis. An embodiment provides an immunological composition useful for inducing the production of antibodies to an antigen in a non-human animal comprising an antigen, preferably a coccidia, and a saponin composition extracted from Hesperaloe. The saponins extracted from Hesperaloe biomass may comprise 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside C, furcreastatin and yuccaloiside C.

Methods of making bioactive compound-loaded nanoparticles are provided. The methods harness naturally-occurring biopolymers to produce nanoparticles from raw plant materials. Methods include contacting plant-derived materials with alkaline solution with agitation to deprotonate the bioactive materials and biopolymers to form nanoparticles. In some forms, the methods contact the nanoparticle with an acid to re-protonate the components and more stable nanoparticles. The bioactive compounds can be extracted from raw plants and / or plant parts, including turmeric, ginger, clove, thyme, pepper, and rosemary. The bioactive compounds include curcumin, gingerols, shogaols, eugenol, thymol, carvacrol, capsaicin, and rosmarinic acid. Compositions and formulations containing bioactive-compound loaded nanoparticles are also provided.

An oral product includes a filler and an active ingredient. The filler includes a modified agglomerate and a surface modifier. The modified agglomerate includes a porous carrier. The surface modifier coats at least a portion of a surface of the agglomerate, is in pores of the agglomerate, or both coats at least a portion of the surface of the agglomerate and is in pores of the agglomerate. The surface modifier includes a sugar alcohol or a hydrophobic material. The active ingredient is admixed with the filler.

The present invention relates to a method and apparatus for predicting the effect of the co-administration of a secondary active compound on the bioavailability of a primary active compound.

The invention relates to novel herbicidal active compound combinations which comprise substituted isoxazolincarboxamides or agrochemical acceptable salts thereof and substituted aminopyridines and aminopyrimidines. They can be used with particularly good results for the control of weeds in various crops of useful plants.

A method for treating a gastrointestinal condition includes preparing an aqueous extract of bioactive compound by adding dried green tea material to hot water and filtering the aqueous extract; adding a solution of an iron-containing compound to the filtered aqueous extract to form a complex or chelate of the bioactive compounds with iron; and drying the solution at a temperature between 80 to 150 degrees Fahrenheit to obtain a fine granular or powdered state.

The application discloses a marine source penicillium and a fermentation method and application thereof. The marine source penicillium is named Penicillium sp. DSF059, and the preservation number is CCTCC NO: M 20232310. Penicilliu The application optimizes the culture condition of the strain, selects a culture medium and culture condition with high yield of antibacterial active compounds to carry out fermentation, so that more target products can be obtained, the operation is simple, the cost is low, and meanwhile, the marine source penicillium Penicilliu Penicillium sp. DSF059 can provide an excellent strain for new drug development of resisting plant pathogenic fungi such as coffee leaf blight, coffee brown spot disease, grape gray mold disease, Chinese cinnamon brown spot disease, citrus black rot disease, pepper late blight, hickory leaf blight, coffee black spot disease and four pathogenic fungi separated from coffee leaf diseases and Staphylococcus aureus, and has a good application prospect for preventing and treating the plant pathogenic fungi and Staphylococcus aureus.

This invention discloses a highly active compound health supplement made from Cordyceps sinensis, Artemisia argyi, and rhubarb, and its preparation method, belonging to the field of health food and pharmaceutical preparation processing technology. The method includes: adding artificial Cordyceps sinensis ultrafine powder, prepared Rhubarb tanguticum fine powder, Artemisia argyi leaf extract, microcrystalline cellulose PH102, and maltodextrin into a mixer and premixing at 25-35 rpm to allow the powder to adhere to the surface of the excipients; after tableting, the tablets are subjected to ultra-high pressure treatment at 350-380 MPa. This invention achieves uniform distribution and performance optimization of the formulation components without damaging the activity of heat-sensitive components through precise coupling of premixing strength and ultra-high pressure modification parameters. Experiments show that the obtained formulation has an adenosine retention rate ≥96%, a dissolution rate ≥85% after 5 minutes, and excellent moisture resistance and mechanical strength, solving the technical problems of large activity loss, easy moisture absorption, and slow dissolution in traditional formulations.

The abstract relates to the field of pharmacy, in particular, to a method for obtaining extracts from medicinal plants and can be used for the production of biologically active additives, cosmetics and medicines with antioxidant, rejuvenating and anti-inflammatory effects. The essence of the utility model is the development of a technology for obtaining a liquid extract rich in biologically active compounds by ultrasonic processing of Rosa platyacantha Schrenk leaf raw materials. The method includes the following steps: 1. Preparation of plant raw materials (grinding to 5 mm); 2. Preparation of extractant (50% ethyl alcohol); 3. Extraction of raw materials and extractant in a ratio of 1:10 (Elma Elmasonic Easy 30H); 4. Filtration of the resulting liquid extract; 5. Packaging and labeling of the finished product. Extraction is carried out at a temperature of 35°C and a frequency of 37 kHz for 30 minutes. The technical result of the proposed approach is the development of a resource-saving technology for obtaining a liquid extract from the leaves of Rosa platyacantha Schrenk, ensuring a reduction in extraction time, a low temperature regime while preserving thermolabile biologically active substances, and an expansion of the raw material base through the use of previously unused parts of the plant.

Disclosed in the present invention are a 2-(1,2,4-triazolyl)benzoyl arylamine active compound for inhibiting a wheat take-all pathogen, and a preparation method therefor. The active compound has a structure as shown in formula I. R1, R3, and R4 are —H, —F, —Cl, —Br, —I, —CN, —NO2, —CF3, —CHO, —C1-C4 alkyl groups, or —C1-C4 haloalkyl groups, or —O—R5; R2 is —H, —F, —Cl, —Br, —I, —CN, —CF3, —CHO, —C1-C4 alkyl groups, or —C1-C4 haloalkyl groups, or —O—R5; X is —F, —Cl, —Br, —I, —CN, —NO2, —CF3, or —COOR6; Y is —H, —F, —Cl, —Br, —I, —CN, —NO2, —CF3, or —COOR6; R5 is —C1-C4 alkyl groups, or —C1-C4 haloalkyl groups; R6 is —C1-C4 alkyl groups, or —C1-C4 haloalkyl groups. The compound I has an excellent inhibition effect on the wheat take-all pathogen and can be applied to prevention and treatment of wheat take-all.

The present invention relates to electrolyte compositions comprising distinct redox-active compounds, namely, a redox-active compound, which is phenazine or a phenazine derivative, and a distinct redox-active compound, which is not phenazine or a phenazine derivative. The present invention also relates to the use of such electrolyte compositions as redox flow battery electrolytes. Accordingly, the invention further provides a redox flow battery comprising said compositions.

The invention discloses a diuron wettable powder herbicide and a preparation method thereof, and belongs to the technical field of herbicide pesticides, the diuron wettable powder herbicide comprises a diuron active compound, a carrier, a suspending agent, a dispersing agent and a cleaning agent, the mass ratio of the diuron active compound to the carrier is (3.0-3.2): 1; the carrier comprises attapulgite and modified attapulgite, and the mass ratio of the attapulgite to the modified attapulgite is 10: (1-4); the modified attapulgite is attapulgite coated with lignin quaternary ammonium salt; according to the diuron wettable powder and the preparation method thereof, the anionic surfactant and the lignin quaternary ammonium salt are induced to be compounded under the acidic condition to form the composite modifier, the quaternary ammonium salt pre-modified attapulgite is taken as a core, the composite modifier coats the attapulgite through secondary electrostatic bonding, and the problem that the diuron wettable powder is poor in suspension effect is solved.

The present invention relates to compounds according to formula (I), which are prodrugs of the psychoactive compound phenethylamine or its derivatives. The prodrugs provided herein exhibit improved pharmacokinetic properties during uptake as compared to phenethylamine (or the respective phenethylamine derivative), as well as reduced side effects resulting from the metabolites thus formed. Due to the affinity of the active phenethylamine compound, inter alia, for the 5-HT2a-receptor, these prodrugs are particularly advantageous for use in therapy, e.g., in the treatment of depression, posttraumatic stress disorder (PTSD), Alzheimer's disease or dementia.

The invention discloses a strain of parateratomycosis aveosphaeroides and application thereof, and belongs to the technical field of microorganism and biological prevention and control. In order to screen new species of fungi and provide alternative strains for application of plant beneficial bacteria in agriculture, a fungus SGSF1293 is separated, and the fungus SGSF1293 is identified to be a new species of the cystis clavatum and is named as the parateratosis aveoensis, and the new species of the cystis clavatum is named as the parateratosis aveoensis. According to the present invention, the activity research results show that the strain SGSF1293 has rice root-knot nematode killing activity, plant pathogen resistance (Brassica oleracea black rot xanthomonas, Pseudomonas syringae, Ralstonia solanacearum and Fusarium oxysporum) resistance, oxidation resistance and phosphorus solubilizing activity; besides, the secondary metabolite of the strain is separated and identified, two active compounds, namely, wintergreen ambrotic acid and brefeldin A, are separated, and the wintergreen ambrotic acid has the activity of killing rice root-knot nematode. The discovery of the strain SGSF1293 and the active metabolite thereof has certain application value in the agricultural fields of plant disease control and the like.

The invention discloses a cell membrane in-situ drug membrane protein target screening method based on variable configuration DNA, and belongs to the technical field of biological medicine. Two pairs of functionalized nucleic acid structures are constructed, the first pair is S1S2 semi-complementary DNA double strands, the second pair is S3S4 DNA-RNA hybrid double strands, and the S1S2 structure is covalently coupled to a non-natural amino acid site-directed modified membrane protein through a click chemical reaction in a living cell to realize tagging of the membrane protein; when the candidate drug coupled in S3 interacts with the membrane protein, triggering an allosteric response system to release the tagged chain in S1; the released DNA tag is subjected to PCR amplification and sequencing, and accurate identification and analysis of a membrane protein target are realized according to a tag sequence. The invention provides a high-specificity and non-in-vitro drug membrane protein target screening technology. According to the technology, active compound discovery or accurate screening of drug membrane protein targets in a living cell in-situ environment can be realized.

The present invention relates to fungicidal compositions comprising a carboxamide (Compound I) and at least one active compound II. The invention also relates to an agrochemical composition comprising the composition and a solvent of a solid carrier. In addition, the invention relates to the non-therapeutic use of the composition of the invention to control phytopathogenic harmful fungi.

The present invention is directed to novel chemical compositions of matter, and in particular novel MDMA class of compounds having substituted methylenedioxyphenethylamine and substituted amphetamine, having a metabolically labile thioether group.

The present invention relates to fungicidal mixtures comprising at least one substituted pyridyl / pyrazidyl dihydrobenzothiazepine compounds (compound I) and at least one active compound II in a weight ratio of from 100:1 to 1 :100; to a method for controlling phytopathogenic harmful fungi using mixtures of at least one compound I and at least one compound II in a weight ratio of from 100:1 to 1:100; to the use of mixtures comprising compounds I and compounds II for controlling phytopathogenic harmful fungi; to agrochemical compositions comprising these mixtures; and to agrochemical compositions further comprising seed.

The application discloses 5-chloro-5-phenyl-4,5-dihydroisoxazole-3-carboxylic acid and derivatives (formula I) thereof, wherein R is selected from H, C1-C6 alkyl, C3-C8 cycloalkyl, preferably H, methyl, ethyl, propyl, isopropyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. The synthesis of related active compounds using the compound of formula I can greatly shorten the synthesis route, improve the yield, and has a wide application prospect.

The invention discloses a method for rapidly screening and identifying an alpha-glucosidase inhibitor from stevia rebaudiana by combining a magnetic MOF immobilized enzyme technology with an ultra-high performance liquid chromatography-time-of-flight mass spectrometry technology. The method is based on an immobilized enzyme technology, screening of the alpha-glucosidase inhibitor in stevia rebaudiana is carried out by means of the affinity binding effect of active small molecules and enzyme and the magnetic separation characteristic of magnetic MOF immobilized alpha-glucosidase, and structural identification of an active compound is carried out by applying an ultra-high performance liquid chromatography-time-of-flight mass spectrometry technology. And finally, verifying the in-vitro alpha-glucosidase inhibitory activity of the screened active compound, and simulating the binding information of the two compounds by means of a molecular docking technology. The method provided by the invention has the characteristics of rapidness, high efficiency, accuracy, easiness in separation from a reaction system and reutilization of the target receptor immobilized alpha-glucosidase, is suitable for screening the alpha-glucosidase inhibitor from complex systems such as traditional Chinese medicines and natural products, and has a wide application prospect.

The invention discloses a method for recovering ethyl pyrimidinol from pirimiphos-methyl synthesis wastewater. The method comprises the following steps: sequentially carrying out primary extraction, alkaline hydrolysis, secondary extraction, decoloration, pH value adjustment to 6-7, reflux and cooling crystallization on the wastewater. According to the method disclosed by the invention, other organic matters in the wastewater can be effectively removed, the product quality is improved, the ethyl pyrimidinol with high purity and high yield can be obtained, the recovery rate is greater than 99%, the purity exceeds 99%, the water content is very low, the obtained ethyl pyrimidinol can be used as a raw material to be directly used for synthesizing a pirimiphos-methyl active compound, the utilization rate of the ethyl pyrimidinol is effectively improved, and the method is suitable for industrial production. The method has the advantages of simple process, convenience in operation, low recovery cost, mild reaction conditions, high recovery efficiency, high purity of recovered products, environment friendliness and the like, effectively solves the problem of stink of the ethyl pyrimidinol recovered by the original method, and obviously reduces the three-waste treatment cost by outsourcing or incineration treatment, and meanwhile, the method has the advantages of simple process, convenience in operation, low recovery cost, mild reaction conditions, high recovery efficiency, high purity of the recovered products, environment friendliness and the like.

This invention application provides compositions containing red yeast rice pigment and their applications, compositions with α-glucosidase inhibitory activity and their applications, and further, their application in α-glucosidase inhibitors, belonging to the technical field of natural active compounds inhibiting α-glucosidase. The compositions of this invention comprise one or both of red yeast rice pigment and red yeast rice pigment: wherein the molar ratio of acarbose to red yeast rice pigment is 400:400-600:300; the molar ratio of acarbose to red yeast rice pigment is 400:200-600:150; and the molar ratio of red yeast rice pigment to red yeast rice pigment is 150:400-200:300. The compositions involved in this invention have a significant synergistic inhibitory effect on α-glucosidase, superior to using the above compounds alone, and can achieve reduced drug dosage and reduced drug side effects.

The invention discloses a chiral alpha-aryloxy benzoxazole acetate compound and a synthesis method thereof, and the chiral alpha-aryloxy benzoxazole acetate compound is an optically active compound with a structure as shown in the following formula I, and comprises a stereoisomer with the same chemical general formula. According to the method, a complex formed by a chiral ligand and metal is used as a catalyst, an electrochemical catalysis asymmetric aryloxylation reaction is used as a key step, and the target chiral compound is accurately and efficiently synthesized with high yield and high stereoselectivity. The preparation method is simple, reaction conditions are mild, atom economy is excellent, and the prepared chiral alpha-aryloxy benzoxazole acetate compound has good biological activity potential, can be widely applied to the field of drug intermediate synthesis and has remarkable biomedical practicability and industrial large-scale production prospects.

A biphasic nutraceutical system designed to deliver GRAS-certified bioactive compound families across two circadian-aligned phases: a daytime formulation supporting metabolic activation and cognitive readiness, and a nighttime formulation facilitating nutritional regeneration and immune balance. Active compounds are encapsulated respectively within phospholipid-stabilized micellar vesicles for sublingual delivery and pH-sensitive polysaccharide hydrogel matrices for delayed absorption. This dual-phase structure enables non-invasive, phase-specific release and enhances nutrient bioavailability without invoking pharmacological mechanisms. The system integrates principles of nutritional chronobiology and adaptive timing to synchronize absorption with physiological receptivity windows. Exclusively composed of GRAS-aligned functional ingredients, it supports general biological function under non-clinical conditions, remaining fully within the regulatory scope of dietary supplements under 21 CFR § 170.30.

The present disclosure describes economical processes to improve the bioavailability of nutraceuticals by formulations that induce micronization and sustained release. The inventive process can be used to increase the solubility and bioavailability of lipophilic and moderately water-soluble nutraceuticals by combining excipients that increase the solubility and induce sustained release of the active compounds. The inventive process also can be used to increase the residence time of highly water-soluble nutraceuticals that are metabolized and eliminated quickly from the body, consequently increasing the therapeutic potential. The disclosed formulations advantageously are freely flowing powders that can be used to formulate with other ingredients into tablets, capsules, or the like; or used as bulk powders.

The invention discloses an RPA-CRISPR / Cas12a system for detecting a cowfish based on environmental DNA (Deoxyribonucleic Acid) and a specific primer, and belongs to the technical field of biological detection. Aiming at the sequence of a COI fragment of a mitochondrial genome of the Jiangsu, an RPA primer with the species specificity of the Jiangsu is designed so as to amplify a target fragment; designing a high-activity and specific crRNA sequence by searching a Cas12a protein recognition site in a corresponding amplification sequence so as to guide the Cas12a protein to recognize a target fragment and activate the trans-cleavage activity of the Cas12a protein; by designing a molecular probe with stable performance, the probe is stably and efficiently cut by a Cas12a-crRNA active compound, and a detection result can be observed in real time through a luminoscope. The detection method is easy to operate, high in sensitivity and good in specificity, detection can be completed only through constant-temperature heating equipment, and a new technology and method are provided for rapid detection and protection of the cowfish.

The application discloses a kind of photothermal dark degradable paper mulch and preparation method thereof, belong to mulch production field.The preparation method of the paper mulch includes: S1.lignite powder, alkaline substance is mixed with appropriate amount of water, heated stirring, solid-liquid separation, obtain solid-state lignite residue and lignite extraction liquid;S2.solid-state lignite residue is mixed with appropriate amount of wood pulp, water, retention and drainage aid, fully stir, obtain lignite residue filled dark wood pulp fiber;S3.with dark wood pulp fiber preparation dark base paper;S4.with lignite extraction liquid and polycondensation active compound preparation impregnation water-based resin;S5.dark base paper impregnation absorbs water-based resin, through drying, the crosslinking solidification of resin is completed in the process that paper is dried, obtain photothermal dark degradable paper mulch.Compared with prior art, the photothermal dark degradable paper mulch of the application has excellent photothermal heating performance, mechanical strength, weed control effect, soil improvement potential and full biodegradable characteristics.

The present invention. relates to a disinfectant composition against parasitic organisms. The invention also relates to a method for disinfecting at least one area to prevent parasitosis. The invention also relates to the use of at least one compound selected from fatty acids and fatty alcohols and which have a chain length of to carbon atoms in a disinfectant composition for improving penetration of active compounds contained in said composition into the durable forms, in particular eggs or oocysts, of parasitic organisms.

The present invention relates to compositions comprising herbicidally active compounds (A) and (B), wherein (A) represents one or more compounds of the general formula (I) or agrochemically compatible salts thereof [component (A)], and (B) represents one or more herbicides [component (B)]. The application further relates to a process and to the use of the herbicidal composition of the invention for the control of harmful plants or for growth regulation.

The present application relates to freeze-dried grinding crushing technical field, disclose a kind of low-temperature drying crushing equipment and the crushing method for whitening active compound raw material, including freeze dryer, mounting in freeze dryer inside backing plate and grinder shell, also include grinding assembly and equal collection component.The present application is by being arranged in freeze dryer inside backing plate, grinder shell, grinding assembly and equal collection component, flower freeze-drying is directly carried out grinding work, without transfer, to improve processing efficiency, and reduce flower and external humidity contact, prevent flower metamorphism, effectively guarantee the quality of flower powder, by setting grinding assembly can continue to throw flower, improve the contact frequency of flower and grinder, improve grinding efficiency, by setting equal collection component can control multiple cup body rotation equal amount of material, without subsequent weighing distribution of operator, save time and manpower.