47 results about "Sibutramine" patented technology

The present invention generally relates to pharmaceutical compositions comprising a dopamine agonist and sedative agent. In a preferred embodiment, the dopamine agonist is optically pure (S)-didesmethylsibutramine. In a preferred embodiment, the sedative agent is optically pure (S)-zopiclone or optically pure (S)—N-desmethylzopiclone. In a preferred embodiment, the dopamine agonist is optically pure (S)-didesmethylsibutramine; and the sedative agent is optically pure (S)-zopiclone or optically pure (S)—N-desmethylzopiclone. The pharmaceutical compositions of the invention are useful in the treatment of restless-leg syndrome and periodic-limb-movement disorder, as well as various sleep disorders. In addition, the present invention relates to a method of treating a patient suffering from restless-leg syndrome, periodic-limb-movement disorder, a sleep abnormality, or insomnia, comprising coadministering a therapeutically effective amount of a dopamine agonist and a therapeutically effective amount of a sedative agent. In a preferred embodiment, the dopamine agonist is optically pure (S)-didesmethylsibutramine. In a preferred embodiment, the sedative agent is optically pure (S)-zopiclone or optically pure (S)—N-desmethylzopiclone. In a preferred embodiment, the dopamine agonist is optically pure (S)-didesmethylsibutramine; and the sedative agent is optically pure (S)-zopiclone or optically pure (S)—N-desmethylzopiclone.

A method for treatment of neuropsychiatric symptoms or disorders emanating from primary brain or systemic impairments includes administration of an effective dose of a dopamine, serotonin, and norepinephrine reuptake inhibitor to a human in need of such treatment. The preferred reuptake inhibitor is sibutramine.

This invention encompasses methods for the treatment and prevention of disorders that include, but are not limited to, eating disorders; weight gain; obesity; irritable bowel syndrome; obsessive-compulsive disorders; platelet adhesion; apnea; affective disorders such as attention deficit disorders, depression, and anxiety; male and female sexual function disorders; restless leg syndrome; osteoarthritis; substance abuse including nicotine and cocaine addiction; narcolepsy; pain such as neuropathic pain, diabetic neuropathy, and chronic pain; migraines; cerebral function disorders; chronic disorders such as premenstrual syndrome; and incontinence. The invention further encompasses pharmaceutical compositions and dosage forms which comprise optically pure (-) sibutramine, optionally in combination with a phosphodiesterase inhibitor or a lipase inhibitor.

A weight-losing fabric is prepared through preparing nanometre microsoftgels from liposoluble sibutramine, VE, essence and oily solvent, and attaching the nanometre microsoftgels to the fabric.

This invention encompasses methods for the treatment and prevention of disorders that include, but are not limited to, eating disorders; weight gain; obesity; irritable bowel syndrome; obsessive-compulsive disorders; platelet adhesion; apnea; affective disorders such as attention deficit disorders, depression, and anxiety; male and female sexual function disorders; restless leg syndrome; osteoarthritis; substance abuse including nicotine and cocaine addiction; narcolepsy; pain such as neuropathic pain, diabetic neuropathy, and chronic pain; migraines; cerebral function disorders; chronic disorders such as premenstrual syndrome; and incontinence. The invention further encompasses pharmaceutical compositions and dosage forms which comprise optically pure (+) sibutramine, optionally in combination with a phosphodiesterase inhibitor or a lipase inhibitor.

The present invention relates to pharmaceutical compositions comprising therapeutic combinations comprising: one or more H3 antagonists / inverse agonists; one or more appetite suppressants selected from the group consisting of CBi antagonists / inverse agonists, sibutramine, phentermine and topiramate; and option one or more HMG-CoA reductase inhibitors. The invention also relates to medicaments and kits comprising the pharmaceutical compositions of the present invention, and methods of treating obesity, obesity related disorders and diabetes using the pharmaceutical compositions of the present invention.

A sibutramine magnetic molecularly imprinted polymer and a preparation method thereof, the molecularly imprinted polymer is a magnetic molecularly imprinted polymer having a core-shell structure with Fe3O4SiO2 magnetic nanoparticles as the core and sibutramine molecularly imprinted polymer as the shell thing. The magnetic molecularly imprinted polymer prepared by the present invention has specific adsorption on sibutramine, which can reduce the interference of other components on the detection of sibutramine, and more importantly, it can be easily and conveniently controlled by an external magnetic field. Complete adsorption, cleaning, desorption, easy to operate, suitable for the inspection of illegally added sibutramine and its active metabolites M1 and M2 in functional foods.

The present application relates to compositions for use in a method of treating and / or preventing mental and behavioral disorders and / or improving mental health and cognitive functions in a subject, comprising:a) Docosahexaenoic acid (DHA) and / or the pharmaceutically acceptable derivatives and / or precursors thereof;b) Eicosapentaenoic acid (EPA) and / or the pharmaceutically acceptable derivatives and / or precursors thereof;c) γ-linolenic acid (GLA) and / or the pharmaceutically acceptable derivatives and / or precursors thereof; andat least a psychostimulant compound selected among methylphenidate HCl, atomoxetine, amphetamine, gamma-hydroxybutyrate, dextroamphetamine, sibutramine, methylenedioxymethamphetamine, and / or an anxiolytic compound selected among fluoxatine, sertraline, paroxetine, fluoroxamine, citralopram, venlafaxine, bupropion, nefazodone, and mirtazapine.The present application also relates to the method of treating and / or preventing mental and behavioral disorders and / or improving mental health and cognitive functions in a subject, comprising administering an effective amount of a composition comprising:a) Docosahexaenoic acid (DHA) and / or the pharmaceutically acceptable derivatives and / or precursors thereof;b) Eicosapentaenoic acid (EPA) and / or the pharmaceutically acceptable derivatives and / or precursors thereof;c) γ-linolenic acid (GLA) and / or the pharmaceutically acceptable derivatives and / or precursors thereof; andat least a psychostimulant compound selected among methylphenidate HCl, atomoxetine, amphetamine, gamma-hydroxybutyrate, dextroamphetamine, sibutramine, methylenedioxymethamphetamine, and / or an anxiolytic compound selected among fluoxatine, sertraline, paroxetine, fluoroxamine, citralopram, venlafaxine, bupropion, nefazodone, and mirtazapine.

A method for treatment of neuropsychiatric symptoms or disorders emanating from primary brain or systemic impairments includes administration of an effective dose of a dopamine, serotonin, and norepinephrine reuptake inhibitor to a human in need of such treatment. The preferred reuptake inhibitor is sibutramine.

A weight-losing fabric is prepared through preparing nanometre microsoftgels from liposoluble sibutramine, VE, essence and oily solvent, and attaching the nanometre microsoftgels to the fabric.

Disclosed is a novel sulphonic acid salt of sibutramine, which has good physicochemical properties. Also disclosed are a method of preparing the compound and a pharmaceutical composition comprising the compound.