63 results about "Chronic disorders" patented technology

The invention discloses an illness state tracking management system and method based on a lingual face diagnosis instrument, and belongs to the technical field of traditional Chinese medicine tongue diagnosis and modern information technology fusion. The system comprises a multi-modal data acquisition module, a data processing and analysis module and an augmented reality visualization module; according to the method, illness state tracking is achieved through the steps of multi-modal data acquisition, data preprocessing and feature fusion, personalized digital twinborn model establishment, augmented reality visualization presentation and the like, multi-dimensional data such as tongue picture macroscopic features and tongue surface microorganism distribution can be integrated, dynamic association between the data is revealed, the health state and the intervention effect are visually displayed, and the method is suitable for being popularized and applied. The method is suitable for the fields of traditional Chinese medicine health management and chronic disease monitoring.

Embodiments of the present invention generally relate to novel immunostimulatory compositions of use to stimulate non-specific immune responses in a subject. In certain embodiments, immunogenic compositions disclosed herein can be directed to use in the eye of a subject. In some embodiments, the immunogenic compositions disclosed herein enhance non-specific immune responses in the eye of a subject to treat or reduce the risk of onset of an eye condition. In other embodiments, compositions disclosed herein can be used to treat eye infections due to a microorganism, tumors of the eye, as well as, chronic wounds or infections of the eye. In some embodiments, immunogenic ocular formulations disclosed herein include combinations of agents for prolonged exposure to the eye for improved outcomes.

This invention relates to a body fluid-based detection device for chronic diseases, which belongs to the field of medical devices. The device includes a body fluid detection fluid channel, a detection probe, a data processing module, and a data display module. The detection probe is disposed within the body fluid detection fluid channel, and the detection probe is connected to the data processing module, which is connected to the data display module. The body fluid detection fluid channels include: a body fluid ion detection channel, a body fluid pH detection channel, a body fluid hydrodynamic characteristic detection channel, a channel for detecting the content of soluble gases such as oxygen, a channel for detecting the physical characteristics of white blood cells and tumor cells, a channel for detecting the electrical characteristics of white blood cells and tumor cells, a channel for detecting the physical characteristics of red blood cells, a channel for detecting the electrical characteristics of red blood cells, a channel for detecting the electrical characteristics of separated body fluids, and a channel for detecting anticoagulation and fibrinolysis functions. This invention enables highly sensitive, non-invasive testing, providing a powerful tool for the early diagnosis of chronic diseases.

A device may receive physical activity data for a subject, wherein the physical activity data comprises raw acceleration data. A device may derive a plurality of metrics from the raw acceleration data, wherein the plurality of metrics comprise a plurality of pattern-related metrics. A device may input the plurality of metrics into a deployed machine learning model. A device may be configured to perform receiving, from the deployed machine learning model, a physical activity score. A device may calculate a risk score for at least one disease or condition based on the physical activity score.

The present invention relates to a composition for the improvement and treatment of muscle diseases and cachexia, wherein diflunisal has the effect of promoting the differentiation and proliferation of myogenic cells, and further has the effect of improving and treating cachexia induced by chronic diseases such as muscle diseases or cancer through effects such as increased muscle mass and recovery of muscle strength.

AI-Driven Multimodal Framework Computer for Early Detection and Remote Monitoring of Chronic Disease

This application provides a method, apparatus, and computer device for joint risk assessment of chronic diseases and comorbidities, relating to the field of medical and health technology. The method includes: performing hierarchical preprocessing on health examination-related data from multiple subjects to generate a standardized dataset containing single-disease labels and comorbidity combination labels; inputting the target data into a single-framework multi-objective collaborative ensemble model to obtain single-disease and comorbidity prediction values; the single-disease and comorbidity prediction values ​​are obtained synchronously through a single inference by the single-framework multi-objective collaborative ensemble model; calculating a comorbidity risk gain value based on the single-disease and comorbidity prediction values, and generating a structured assessment result based on the comorbidity risk gain value. This method can improve the accuracy of joint risk assessment of chronic diseases and comorbidities.

The disclosure generally relates to ready to drink electrolyte solution. In particular the disclosure relates to a ready to drink electrolyte solution comprising isomaltulose, glucose, sodium ions, chromium ions and water; wherein the glucose concentration is greater than or equal to 0.9g / 100ml, and wherein the theoretical glycemic index of the solution is equal to or less than 55. The disclosure also relates to a method of manufacturing said ready to drink electrolyte solution. The disclosure also relates to a method of rehydrating a patient suffering from cancer, diabetes, acute or chronic illness, or a gastrointestinal disorder by using said ready to drink electrolyte solution.

The present invention is directed to the use of antiviral agents, in particular valomaciclovir stearate and its polymorph Form A, as well as H2G (omaciclovir) to treat multiple sclerosis in combination with other agents, as well as the use of these agents to treat diseases and conditions such as chronic mononucleosis, long COVID, chronic fatigue syndrome, fibromyalgia, Crohn's disease, ulcerative colitis, rheumatoid arthritis, systemic lupus erythematosus, Graves' disease, Alzheimer's disease, mesial temporal lobe seizures, Epstein-Barr-virus-linked autism, or an Epstein-Barr-virus-linked cancer.

In various embodiments compounds that induce and / or promote autophagy are provided as wells as methods of use thereof (e.g., in the prophylaxis or treatment of chronic pathologies associated with aging). In one illustrative, but non-limiting embodiments the compound(s) comprise, inter alia, coumarin 106.

The invention discloses an ordering method and platform based on individual health, and the method comprises the steps: obtaining an iris image of a user, and recognizing the body health risk information of the user through iris detection, analysis and processing; generating a catering recommendation rule according to the obtained body health risk information of the user; the ordering platform screens a food list according to the ordering condition of the user and the catering recommendation rule, and then presents catering recommendation information; or the ordering platform screens the food list according to the ordering condition of the user, generates risk prompt information according to the catering recommendation rule, and presents the catering recommendation information and the risk prompt information; the user performs ordering selection; according to the scheme, by combining the iris detection technology and the Internet ordering platform, the health risk of the user can be effectively recognized, personalized diet recommendation and health risk prompt are provided, the user is helped to enjoy online ordering and online take-out convenience, diet health can be guaranteed, and chronic diseases can be prevented and controlled.

To provide a new compound useful for treating cachexia or wasting syndrome which is a severe complication of chronic diseases such as neurodegenerative diseases and cancer.SOLUTION: Compounds of formula Ib or Ic are described. The compounds can modify the Akt3 or effects of nature in vitro or in vivo, and can also be used, alone or in combination with other agents, in the prevention or treatment of various conditions.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of medicines, and particularly relates to a probiotic-fermented medicinal and edible traditional Chinese medicine composition as well as a preparation method and application thereof. Specifically, the medicinal and edible traditional Chinese medicine composition comprises the following components: Chinese yam, lotus seed, white hyacinth bean, fingered citron, dandelion, coix seed, Chinese date, malt and liquorice. According to the invention, the medicinal and edible traditional Chinese medicine raw materials are crushed, and the probiotics are added for fermentation treatment, so that the medicinal and edible traditional Chinese medicine composition based on probiotic fermentation is obtained, and the composition has a good curative effect on chronic diseases such as gastrointestinal diseases and the like, thereby having a good practical application value.

Described herein are treatment regimens, therapies, pharmaceutical formulations and methods of using quercetin to prevent, treat, and / or protect from muscle wasting including 1) sarcopenia associated with aging; and 2) cachexia associated with chronic diseases and their treatments including but not limited to cancer, cardiovascular disease, chronic obstructive pulmonary disease (COPD), HIV, and kidney disease.

The present invention concerns the assessment of mechanical tissue properties in vivo. For this, magnetic resonance elastography (MRE) is often used but suffers from a poor adaptability of the reconstruction process of the mechanical tissue properties based on the images taken by MRE. There is therefore a need for a method for determining mechanical parameters of a tissue of a subject, which is adapted to his / her specificities. The present invention provides with a novel reconstruction process fulfilling this need by a smart use of resampling. This improvement is also advantageous to diagnose chronic diseases or provide biomarkers / therapeutical targets relative to chronic diseases by using these better assessed mechanical tissue properties provided by the novel reconstruction process.

Methods, systems, and computer-readable media are disclosed herein for generating a disease-agnostic data model that can be used to predict the onset of multiple chronic diseases in individual patients. In an aspect, the data model is made by autonomously selecting features from longitudinal medical records of patients having chronic diseases that will become predictors for the onset of a chronic disease. The features are vectorized around a disease onset date and processed through a recurrent neural network to produce the data model. Then, the data model may leveraged to predict, for new longitudinal medical records that are input, a future time period when another patient is predicted to experience the onset of the chronic disease. The same data model may utilized to make predictions for multiple chronic diseases.

This invention discloses the application of a composition in the preparation of foods or medicines that reduce blood lead levels, belonging to the field of food or pharmaceutical applications. The composition is for improving intestinal microecology, comprising inulin, galactooligosaccharides, polydextrose, and water-insoluble dietary fiber, wherein the weight ratio of inulin, galactooligosaccharides, polydextrose, and water-insoluble dietary fiber is 25:25:20:30, and the composition is taken immediately after being dissolved in warm water before meals. This invention, through the rational combination of water-insoluble dietary fiber and functional polysaccharides, adjusts the release rate of nutrients in the intestine, slows down digestion, absorbs and eliminates toxic substances from food, reduces intestinal permeability, and simultaneously possesses the functions of water absorption and swelling, gradient adhesion, mechanical isolation, mesh adsorption, ion exchange, and microbial regulation, providing a favorable environment and food for the growth of intestinal microorganisms, and effectively reducing blood endotoxins and blood lead levels, enhancing immunity, and preventing chronic diseases.

The invention provides a compound weight-losing meal replacement and a preparation method thereof. The compound weight-losing meal replacement is prepared from 6-20 parts of angelica keiskei freeze-dried powder; 4-10 parts of barley leaf freeze-dried powder; 5-15 parts of cooked quinoa powder; 10-40 parts of high-protein bean flour; 3-15 parts of milk powder; 2-8 parts of cooked white hyacinth bean powder; 3-10 parts of walnut powder; 2-6 parts of highland barley powder; 0-5 parts of laver dry powder; 0-8 parts of kale freeze-dried powder; 2-8 parts of jujube powder; 0-3 parts of dried ginger powder; after the meal replacement disclosed by the invention is used, the weight of a tested object is obviously reduced, the tested object does not suffer from chronic diseases such as malnutrition and the like, the physical fitness of the tested object is enhanced, and the meal replacement disclosed by the invention is comprehensive in nutrition, free of toxic and side effects and free of toxic and side effects. The composition can be used in health-care products or medicines for regulating blood fat.

The present application relates to a kind of community chronic disease auxiliary decision system, including knowledge warehouse end, value evaluation end and learning network end;Knowledge warehouse end provides the rule and constraint of disease treatment scheme;Value evaluation end provides the value index of evaluation treatment result, value includes treatment benefit, damage and cost;Learning network end is used for the collection and storage of patient state data, generates treatment scheme collection, obtains patient value collection, obtains the highest comprehensive value from multiple treatment schemes as decision scheme, predicts the possible treatment scheme of patient and the value generated by scheme, feedback to treatment scheme by value evaluation system, to obtain the recommended scheme order and its corresponding value.The above model is established application platform, and is tested and improved by community empirical research.The present application will provide technical tool for the standardized management of community medical institutions T2DM, and provide methodological reference for the research of other chronic disease individualized treatment auxiliary decision system.

Provided herein are thiazole amide compounds (e.g., Formula (I)) for use in enhancing human immune response and / or as adjuvants in vaccines. The compounds described herein are used as enhancers of an immune response (e.g., innate and / or adaptive immune response), and are useful in treating and / or preventing a disease, as adjuvants in a vaccine for the disease, (e.g., proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease). Also provided in the present disclosure are compositions (e.g., pharmaceutical composition), kits, methods, and uses including or using compounds described herein.

The invention provides a whole-plant purple corn anthocyanin substitutional tea formula and a preparation process thereof, and relates to the technical field of substitutional tea processing, and the whole-plant purple corn anthocyanin substitutional tea formula is prepared from the following raw materials: a whole-plant purple corn raw material, purple corn stigma, medicinal and edible auxiliary materials, a natural sweetening agent, an anthocyanin protective agent, citric acid and beta-cyclodextrin. The beverage has strong antioxidant ability, can effectively remove free radicals in the body, slow down the cell aging process and prevent various chronic diseases, and meanwhile, anthocyanin also has the effects of resisting inflammation and protecting eyesight, can relieve eye fatigue and prevent eye diseases, and meets the requirements of consumers on health and health preservation; the anthocyanin protective agent and the beta-cyclodextrin are added, so that the substitute tea can still keep higher anthocyanin content after being stored for a long time, and the nutritional value and the efficacy of the product are maintained.

Aging in an individual refers to the temporal change, mostly decline, in the body's ability to meet physiological demands. Biological age (BA) is a biomarker of chronological aging, and can be used to stratify populations to predict certain age related chronic diseases. BA can be predicted from biomedical features such as brain MRI, retina or facial images, but the inherent heterogeneity in the aging process limits the usefulness of BA predicted from individual body systems. The methods disclosed herein teach a multi-modal Transformer-based architecture with cross-attention which was able to combine facial, tongue and retina images to estimate BA. The model was trained using facial, tongue and retina images from 11, 223 healthy subjects, and demonstrated that using a fusion of the three image modalities achieved the most accurate BA predictions. The approach was validated on a test population of 2,840 individuals with six chronic diseases, and obtained significant difference between chronological age (CA) and BA (AgeDiff) than that of healthy subjects. AgeDiff has the potential to be utilized as a standalonfe biomarker, or conjunctively alongside other known factors for risk stratification and progression prediction of chronic diseases. The results therefore highlight the feasibility of using multi-modal images to estimate and interrogate the aging process.

The invention relates to the technical field of chronic disease management, in particular to an intelligent chronic disease management system based on LC9 multi-dimensional quantitative evaluation and adaptive feedback optimization, and the system comprises the steps: obtaining nine-dimensional original data containing health behaviors, biological indexes and psychological states through a data collection module; the health assessment engine generates a health state index through fusion by using a dynamic weight algorithm; the personalized intervention strategy device generates and decomposes an intervention scheme according to the result; and the adaptive feedback optimizer dynamically adjusts the evaluation weight according to the user execution compliance to form closed-loop optimization. Meanwhile, the system is integrated with an acute event early warning module, and intelligent recognition and early warning of acute cardiovascular events are achieved by fusing clinical symptoms described by natural languages and real-time physiological data. According to the invention, the defects of single evaluation, stiff strategy and insufficient early warning of the existing system are overcome, and real personalized and self-adaptive chronic disease intelligent management is realized.

Various embodiments of a gut microbiome modulating composition comprises a blend of a polyphenol and an oligosaccharide. Various embodiments of the polyphenol may comprise at least approximately 5% by weight chlorogenic acid. Various embodiments of the oligosaccharides may be standardized to a degree of polymerization of at least three to reduce digestibility. Administration of an effective amount of the gut microbiome modulating composition to a person or animal may stimulate the growth of at least one of Akkermansia muciniphila, Lactobacillus, and Bifidobacterium bacteria in the colon, which may reduce permeability of the colon, increases short chain fatty acid production in the colon, and / or modulate causes immunomodulation of human colon cells. The gut microbiome modulating composition may provide protective effects against obesity-related chronic diseases.

The present invention provides solid, crystalline forms of Compound I. Compound I has the structure:The invention further provides methods for treating, preventing, or reducing a disease or disorder in a subject in need thereof, the methods comprising administering to the subject an effective amount of a crystalline form of Compound I. The disease or disorder may include any chronic disease and / or cardiovascular condition related to or caused by high blood pressure.

The present specification discloses methods for delivering sustainable healthcare to a patient-population suffering from a chronic condition to improved healthcare outcomes. The disclosed methods comprises aligning stakeholders involved in delivering care to the patient-population based on common metrics of success; establishing an advance primary care team to liaison with the patient-population and a community where patient-population resides to facilitate a delivery of care program; identifying the patient-population by assessing one or more individuals suffering from the chronic condition by risk stratification parameters; and implementing a sustainable value-based payment scheme. The disclosed methods may further comprise a data management step that provides a data infrastructure that facilitates analysis and reporting to enable transparent data sharing of each patient-population member linked to outcomes and cost and / or a technology platform step that implements an interoperable and flexible healthcare framework that monitors delivery of care and healthcare outcome of each patient-population member.

The present invention refers to micro-fragmented fat or a composition comprising micro-fragmented fat for use in the treatment of a systemic disease, preferably associated to or caused by sepsis. Moreover, the micro-fragmented fat or the composition comprising micro-fragmented fat is used for treating a systemic, inflammatory, immune, or chronic disease, said disease being intended as a consequence of septic disease. Preferably, the micro-fragmented fat is useful for treating both the acute (early) and late stages of sepsis.

This invention discloses a tea pectin polysaccharide and its application in immune regulation and prevention of colitis, relating to the field of biomedical technology. The invention provides a tea pectin polysaccharide whose main chain structure is composed of (1→4)-α-D-GalpA-(1→) linked together, with the repeating structural unit being (1→4)-α-D-GalpA. The (1→4)-α-D-GalpA-(1→) residues of the tea pectin polysaccharide exhibit acetylation at positions O-2 and O-3, and methyl esterification at position C-6, with a degree of acetylation of 14.80% and a degree of methyl esterification of 42.47%. The main chain structure of the pectin polysaccharide after oxidative degradation is composed of α-D-G... The structure consists of alpA-(1→4)-α-D-GalpA-(1→link and →4)-α-D-GalpA-(1→4)-β-D-GalpA links, with the linking sites located at positions O-4. The tea pectin polysaccharide of this invention and its related preparations exhibit excellent immunomodulatory effects, playing a significant role in anti-inflammatory and anti-cancer processes. It is particularly valuable in the prevention and treatment of colitis, cardiovascular diseases, immune diseases, neurodegenerative diseases, and other chronic diseases.