306 results about "Microcirculation" patented technology

The invention discloses a microcirculation blood vessel automatic segmentation and quantification method based on enhanced feature fusion. The method comprises the following steps: step 1, data preparation and preprocessing; 2, designing an enhanced feature fusion network model; step 3, automatically segmenting microcirculation blood vessels; and 4, quantifying the diameter of the blood vessel based on the segmentation result. According to the enhanced feature fusion network model provided by the invention, accurate segmentation of microvessels is realized through fusion and enhancement of multi-scale features. The model shows good generalization ability on diversified clinical image data through effective data enhancement, and can adapt to image data with different illumination conditions, contrast ratios and resolutions. Therefore, the model has high practicability and reliability in practical application. According to the method, the diameter of the blood vessel is quantified through the segmentation result, the diameter of the microvessel can be accurately measured, and powerful support is provided for evaluation of the clinical microcirculation function.

A computer-implemented method and a system for calculating a pressure drop along one or more vessels comprising one or more stenosis, the method comprising: obtaining at least one two-dimensional image of the vessels; obtaining a centerline and a boundary of each vessel by image processing algorithms; calculating a length and a diameter of each vessel; calculating a baseline volumetric flow (Qb); deriving a hyperaemic volumetric flow rate (Qh); determining a set of stenosed parts; defining a proximal part, between an inlet and a first stenosed part, a distal part, between last stenosed part and outlet, and a set of normal parts, between two stenosed parts; calculating a pressure drop at a proximal part, at a distal part, at normal parts and at stenosed parts, and calculating a total pressure drop ΔP from inlet to outlet of the vessel. Also, calculating resistance indices of the stenosis and of the microcirculation.

The invention discloses a pressure injury risk early warning method and equipment, and relates to the technical field of medical monitoring instruments. The pressure sensor array layout can be self-adaptive to the body shape of a patient, a key osseous process part is covered, no monitoring dead angle is ensured, a temperature compensation mechanism is built in, environmental interference is reduced, the measurement precision is improved, an abnormal pressure threshold value can be dynamically set based on individual medical record data, data verification is performed before early warning is triggered, false alarm is avoided, and the array structure is light, thin and flexible. The mask is comfortable to fit skin, supports long-term wearing and is easy to disinfect and maintain; environment temperature and humidity parameters and pressure data are subjected to fusion analysis, the influence of a high-temperature and high-humidity environment on skin microcirculation can be recognized, the risk of pressure sores can be evaluated in an auxiliary mode, a calibration algorithm is built in a sensor, environment fluctuation interference is reduced, and data reliability is ensured; and the early warning unit comprises sound-light alarm equipment which supports a multi-stage alarm mode and is used for triggering an early warning signal and pushing information when the risk index exceeds a threshold value, so that the early warning timeliness is ensured and the false alarm risk is reduced.

The invention discloses a multi-mode synchronous monitoring method and system based on traditional Chinese medicine pulse conditions and microcirculation, and relates to the technical field of traditional Chinese medicine intelligent diagnosis. A pulse position coordinate set is generated by combining a preset space mapping relation; a pulse pressure signal and a microcirculation blood flow image are synchronously acquired; frequency domain transformation is performed on the pulse pressure signal and a pathological risk probability L is calculated; a comprehensive node feature vector is constructed to form a graph structure; a pathology mode recognition result is output by matching a pathology sub-atlas template library, dynamic correlation analysis of traditional Chinese medicine pulse conditions and microcirculation is achieved, and the technical bottlenecks that traditional pulse diagnosis is high in subjectivity, multi-mode asynchronous and difficult in pathology quantification are broken through.

The invention provides a real-time processing method for endoscopic image blood vessel enhancement and microcirculation evaluation, which comprises the following steps of: processing an original endoscopic image, and locally enhancing a brightness channel through a contrast-limited adaptive histogram equalization technology; self-adaptive frequency domain-space domain decomposition is realized based on local texture complexity analysis; performing multi-scale Hessian matrix blood vessel detection on the low-frequency component; applying a directional Gabor filter bank to the high-frequency component; spatial-temporal feature fusion is realized through multi-resolution pyramid optical flow calculation; synchronously completing blood vessel probability prediction, blood vessel diameter estimation and blood flow direction prediction by using a lightweight multi-task deep learning network; the blood flow velocity is analyzed and calculated based on a speckle mode, the perfusion density is subjected to accelerated statistics through an integrogram, and vascular morphological parameters are extracted by adopting an improved skeleton algorithm. According to the invention, an enhanced blood vessel visualization effect and a real-time microcirculation quantitative evaluation function can be provided, and the overall improvement of the endoscope image processing quality and efficiency is realized.

The invention discloses a bedside skin flap blood flow monitoring and early warning device and computing equipment, and the device comprises a skin flap tissue perfusion monitoring module which comprises a probe housing, a microcirculation blood flow velocity sensor, a tissue oxygenation degree sensor and a flexible connecting arm; the data acquisition and transmission module is used for receiving the blood flow velocity data and the oxygenation degree data through a data line and carrying out analog-to-digital conversion and data packaging; the central processing unit comprises a data storage module, a data analysis module and an early warning module; the data analysis module comprises a baseline establishment sub-module, an anomaly detection sub-module and a trend prediction sub-module; and the early warning module is used for displaying a red alarm through a bedside display screen and sending a short message alarm containing the patient name, the bed number, the early warning type and the severity information to a medical staff mobile terminal through the wireless notification module. According to the invention, the abnormal condition of skin flap blood perfusion can be found and predicted in time, and the workload of medical staff is reduced.

The invention discloses a wound healing state evaluation method and system based on artificial intelligence, and belongs to the field of wound healing evaluation. The method comprises the following steps: integrating medical record data and wound physiological parameters, and extracting relevance between a medication history and an infection type to form a multi-dimensional pathological factor; hemoglobin oxygenation, blood flow and metabolic heat are subjected to cross-period correlation analysis to construct dynamic physiological time-space information, pathological factors and the physiological time-space information are fused into a heterogeneous graph, nodes comprise drug intensity quantized values, infection risk levels and microcirculation fluctuation values, and edge weights are determined by the time sequence matching degree of drug doses and blood flow changes; based on the node weight and the edge association relationship, the treatment time and the physiological parameter acquisition period are aligned to generate a spatio-temporal evolution matrix, the spatial distribution of the infection risk level and the metabolic heat value characteristics are combined, the dynamic association of the drug action intensity and the microcirculation fluctuation is analyzed, and wound healing evaluation information is generated. The accuracy of wound healing state evaluation can be improved.

The invention provides a preparation method of medicinal liquor and application of the medicinal liquor in preparation of products for preventing cardiovascular and cerebrovascular diseases and improving microcirculation, and belongs to the technical field of pharmaceutical compositions. The preparation method comprises the following steps: (1) crushing; (2) extracting; (3) standing and separating; and (4) freezing and filtering to obtain the medicinal liquor. In the preparation process, traditional Chinese medicine components are extracted through the steps of batch crushing, mixed extraction, standing, freezing and separation of supernate and suspension in different separation modes to obtain the medicinal liquor, and the medicinal liquor is high in active ingredient activity, good in stability, free of layering after being placed for a long time, free of sediment and free of toxic and side effects. And the traditional Chinese medicine composition has obvious effects on preventing cardiovascular and cerebrovascular diseases and improving microcirculation.

The invention provides a composition which comprises two components, and the component A comprises lutein; and the component B comprises a berry fruit extract containing anthocyanin. The composition has the effects of eliminating free radicals, resisting oxidation, protecting eyes, inhibiting tear secretion reduction, relieving eyestrain and eye dryness, relieving ciliary muscle tension, repairing retina, preventing and controlling ocular axes, protecting eyesight, preventing myopia, improving eye microcirculation, improving couperose skin and the like.

The invention provides eye protection liquid for improving eye microcirculation and a preparation method thereof, and belongs to the technical field of medical configuration products. The composition comprises the following components: surface-modified magnetic nanoparticles, a calendula extract, a fermented dogwood extract, xanthophyll, taurine, sodium hyaluronate, hydrolyzed sodium hyaluronate, soya bean lecithin, borneol and fermented vegetable oil. The efficiency of active ingredients is improved through a double-fermentation technology, magnetic targeting and multi-channel compounding are combined, and the preparation method has remarkable advantages in the field of improving periorbital microcirculation. The traditional Chinese medicine composition has an obvious relieving effect on asthenopia and dry skin around eyes; the components of the eye microcirculation eye protection liquid are mild, and adverse reactions such as allergy cannot be caused.

The invention discloses a hematopoietic preparation for treating androgenetic alopecia and a preparation method of the hematopoietic preparation. The hematopoietic preparation is prepared from 5-30 parts of radix polygoni multiflori preparata, 5-30 parts of wine ligustrum lucidum ait, 5-30 parts of mulberry, 5-30 parts of eclipta, 5-30 parts of radix paeoniae alba, 5-30 parts of astragalus membranaceus and 5-30 parts of rhizoma cibotii. The medicine composition and the specific dosage are obtained through a large number of experimental screening and clinical medication experience screening. The whole formula takes tonifying liver and kidney and benefiting essence and blood as the monarch, and takes tonifying spleen and qi and removing heat to cool blood as the minister and assistant, based on the traditional Chinese medicine theory that essence is stored in kidney and is warmed on hair, by inhibiting DHT generation, resisting hair follicle apoptosis and improving scalp microcirculation, the traditional Chinese medicine composition has the remarkable effect of treating androgenetic alopecia, is weak in toxic and side effects, and can be prepared into various clinical dosage forms.

The invention discloses an intracranial anterior artery circulation functional evaluation method and device, computer equipment and a storage medium, and relates to the field of vascular function evaluation, and the method comprises the steps: based on an intracranial angiography image and near-end pressure data, carrying out the five working processes of data input, blood vessel segmentation and segmentation, boundary condition calculation, hemodynamic simulation and functional parameter calculation; according to the method, functional parameters verified in the coronary artery field are migrated to intracranial blood vessel evaluation without additional equipment, the clinical problem that traditional morphological evaluation is not matched with functionality is solved, individualized function quantification is achieved by integrating blood vessel morphological characteristics and hemodynamic simulation, and the method is suitable for being applied to intracranial blood vessel evaluation. According to the method, an objective basis is provided for cerebrovascular disease diagnosis and treatment, the intracranial vascular disease is promoted to be converted from anatomy orientation to function orientation, the clinical decision accuracy is remarkably improved, popularization and application of functional evaluation in the field of neural intervention are accelerated, and construction of a cerebrovascular disease accurate diagnosis and treatment system is assisted.

The invention relates to the technical field of intraoperative intelligent monitoring, and particularly discloses a spinal canal debonding method and system for real-time state evaluation, and the method comprises the steps: collecting neural structure microcirculation blood flow data in real time through integrating a micro-sensing unit at a working end part of a surgical instrument, and extracting blood flow oscillation frequency and capillary hematocrit parameters; performing multi-scale signal decomposition on the blood flow oscillation frequency to obtain an energy distribution parameter, and performing dynamic mode recognition on the hematocrit data to obtain a main variation characteristic value; fusing the two characteristic parameters to generate a nervous tissue vitality index; inputting the index into a pre-trained neural network for time sequence feature analysis, and outputting a graded ischemia risk early warning signal; the operation rhythm is automatically adjusted through a decision tree control mechanism based on the early warning signal, and self-adaptive regulation and control according to the state of the nervous tissue are achieved; the technical problem that the risk of neural ischemia cannot be monitored in real time in a traditional spinal canal release operation is solved, and occult nerve injury caused by asymptomatic neural ischemia can be prevented.

The invention discloses an application of alpha-ketoglutaric acid in preparation of a medicine for promoting hypertension angiogenesis, belongs to the technical field of biological medicines, and finds that the alpha-ketoglutaric acid has the effects of promoting hypertension angiogenesis and improving microcirculation injury for the first time, and provides a new thought for diagnosis and treatment of sparse microcirculation. Alpha-ketoglutaric acid has good drug safety and a strong angiogenesis promoting effect, and can be used as a candidate drug for promoting angiogenesis. And the DM-alpha KG is alpha-ketoglutaric acid which can be absorbed by cells, can be dissolved in DMSO, and is good in stability, low in cytotoxicity and good in drug safety. Results show that the alpha-ketoglutaric acid has relatively good drug safety and relatively strong angiogenesis promoting effect, and can be used as a candidate drug for improving sparse blood vessels.

The invention relates to the technical field of medical detection, and particularly discloses a human body microcirculation change monitoring method and device, and the method comprises the steps: responding to a starting instruction, and selecting a first judgment mode as a microcirculation judgment mode; in the first judgment mode, the microcirculation state of the patient is determined according to the body surface skin temperature and the intracavity temperature; responding to a judgment result that the environment temperature meets the first switching condition, and switching the microcirculation judgment mode into a second judgment mode; in the second judgment mode, the microcirculation state of the patient is determined according to the body surface skin temperature and the ideal body surface skin temperature corresponding to the environment temperature; responding to the judgment result that the environment temperature meets the second switching condition, and switching to the first judgment mode. The microcirculation change of the patient is evaluated based on the body surface skin temperature, the intracavity temperature and other information of the specific limbs of the patient, non-invasive monitoring on the microcirculation change of the patient can be achieved, and then early warning analysis on the illness state of the patient can be achieved according to the microcirculation change condition of the patient.

The invention relates to the technical field of intelligent diagnosis and treatment, and discloses an intelligent diagnosis and treatment system for dynamic risk early warning and intervention of orthopedic patients, and the system comprises a dynamic monitoring end, an intelligent grading end, a precise intervention end, a voice alarm module and a doctor's advice cooperation module. A multi-source sensor is used for continuously collecting vital signs of a patient and local microcirculation and behavior data of an affected limb in real time, and dynamic fusion analysis is carried out based on an orthopedic specialized risk model, so that early abnormal changes of deep venous thrombosis, stress injury and falling risks can be recognized in real time; the method overcomes the hysteresis quality of traditional manual intermittent evaluation and static scale, ensures the accuracy and timeliness of early warning of severe risks, and reduces clinical risks caused by untimely intervention.

The invention relates to the field of artificial intelligence medical treatment, in particular to a multi-modal feature fusion analysis system and method for gynecological face diagnosis, and aims to improve the early diagnosis precision of gynecological diseases, the system fuses multispectral images and symptom text data, and captures capillary morphology and hemodynamic parameters through a microcirculation feature extraction module; the region mapping analysis module is combined with the face region-gynecological viscera knowledge graph to generate viscera abnormality scores; the endocrine cycle modeling module constructs a dynamic model based on historical data and monitors cycle abnormity; the semantic attention fusion module fuses the symptom text and the microcirculation features by using a bidirectional cross attention mechanism to form a fusion feature vector; the knowledge reasoning feedback module is used for generating a diagnosis result and a personalized conditioning scheme based on dynamic knowledge graph multi-path reasoning, and optimizing a diagnosis and treatment path. The system overcomes the limitation of a traditional two-dimensional RGB image, effectively captures the subepidermal microcirculation state, and provides an important basis for early diagnosis of gynecological diseases.

The invention discloses a nursing method and system based on a hierarchical monitoring mode, and relates to the technical field of monitoring nursing, and the method comprises the following steps: firstly, according to a preset detection period, carrying out the regular detection of the skin microcirculation perfusion state of a severely burnt patient, and evaluating the tissue perfusion and wound recovery conditions; by monitoring skin microcirculation changes in real time and combining a deep learning model, the scheme accurately captures early characteristics of blood hypercoagulability trend, such as microcirculation shear stress and pulsation strength changes, generates blood flow indexes, compares the blood flow indexes with reference thresholds, early recognizes the hypercoagulability state and timely intervenes; the risks of local necrosis, infection, septicemia and the like are reduced. Based on intelligent division, patients are divided into blood rheological balance and blood hypercoagulability trend, the detection frequency is dynamically adjusted, nursing resource allocation is optimized, personalized nursing is achieved, and prognosis and management quality of the patients are effectively improved.

A microcirculation reconstruction bone implant capable of generating internal stress comprises a support shell and a support inner core. The support inner core is sleeved with the support shell, and the support shell and the support inner core form a matched structure. The stent shell is located between the bone tissue and the stent inner core, and the stent shell generates elastic deformation to generate internal stress and applies the internal stress to the surrounding bone tissue when the stent is implanted and loaded; a microcirculation reconstruction passage is also loaded on the stent inner core; by adopting a mode that the stent inner core is matched with the stent shell, the stent inner core is matched with the stent shell to form an elastic effect, so that internal stress can be continuously applied to bone tissues in postoperative application to promote bone growth and integration; and a complex stress environment can be adaptively adjusted, so that the stress compatibility between the implant and a bone tissue is ensured, new intraosseous circulation is established, and the postoperative healing effect after the implant is applied is promoted.

The invention relates to the technical field of traditional Chinese medicine, and discloses a plaster for treating bone fracture and a preparation method thereof, and the plaster comprises the following raw materials: peach kernel, safflower, ligusticum wallichii, radix cyathulae, rhizoma drynariae, radix angelicae pubescentis, notopterygium root, eucommia ulmoides, astragalus membranaceus, pseudo-ginseng, native copper, dragon's blood, catechu, angelica sinensis, radix rehmanniae, gentiana macrophylla, radix saposhnikoviae, earthworm, centipede, scorpion, ground beetle, liquorice, frankincense, myrrh, yellow lead, sesame oil and other auxiliary materials. Pseudo-ginseng is added into the formula, the effects of promoting blood circulation to remove blood stasis, diminishing swelling and relieving pain of pseudo-ginseng are utilized, absorption of blood stasis of the bone fracture part can be accelerated, then pain and swelling caused by blood stasis blocking are remarkably relieved, blood circulation is promoted, and injury repair is promoted, and radix angelicae sinensis and radix rehmanniae are added into the formula, and the effects of replenishing blood and promoting blood circulation of radix angelicae sinensis and nourishing yin and cooling blood of radix rehmanniae are utilized, so that the bone fracture can be cured, and the bone fracture can be cured. And blood generation and local microcirculation improvement can be promoted, so that the blood supply and oxygen supply capacity of a bone fracture repair part is enhanced, and soft tissue repair is accelerated.

The invention relates to the technical field of medical detection, and particularly discloses a human body microcirculation change monitoring method and device.The human body microcirculation change monitoring method comprises the steps that the body surface skin temperature of a specific limb of a patient and the intracavity temperature of the patient are monitored; when the first difference value between the intracavity temperature and the body surface skin temperature is larger than a third threshold value, it is judged that microcirculation insufficiency occurs at the specific limbs of the patient. Monitoring the change condition of the first difference value in a third preset time period; when the first difference value is gradually reduced in a third preset time period, judging that the microcirculation blood flow of the patient enters a recovery state; and when the first difference value is gradually increased in a third preset time period, judging that the microcirculation blood flow of the patient enters a deterioration state. The microcirculation change of the patient is evaluated based on the body surface skin temperature, the intracavity temperature and other information of the specific limbs of the patient, non-invasive monitoring on the microcirculation change of the patient can be achieved, and then early warning analysis on the illness state of the patient can be achieved according to the microcirculation change condition of the patient.

The invention relates to the technical field of cosmetics, in particular to a composition for promoting skin microcirculation as well as a preparation method and application thereof, and the key point of the technical scheme is that the composition consists of the following components: rhizoma bletillae, motherwort, poria cocos, moutan bark, ginseng, peach blossom and lotus. According to the composition, the deep-eutectic solvent is combined with a micro-jet extraction technology, so that the extraction efficiency of active ingredients such as flavonoids is remarkably improved, and functional ingredients for resisting oxidation, resisting aging and promoting blood circulation are effectively reserved. According to the composition disclosed by the invention, the comprehensive effects of improving skin microcirculation, relieving dark skin color and delaying senescence are systematically realized by efficiently extracting active substances, activating a microcirculation core pathway and cooperating with coherent effects of a whitening and repairing mechanism.

The invention relates to a composition containing nucleic acid and polypeptide and application thereof. The composition comprises nucleic acid, polypeptide and auxiliary materials. The nucleic acid and the functional polypeptide are compounded and combined, the problems that a single polypeptide is short in half-life period and short in-vivo retention time are solved, meanwhile, the composition can effectively promote tissue regeneration, stimulate regeneration of fiber cells and collagen, repair skin barriers and improve wrinkles, and can effectively improve blood vessel microcirculation and reduce hyperpigmentation while resisting wrinkles in a synergistic mode. The product disclosed by the invention is produced by a sterile process, is high in safety, and can be applied to the medical cosmetology fields such as plastic and aesthetic surgery, trauma healing and the like.

The invention discloses a coronary artery lesion detection method based on retinal vessel marker concept perception and multi-modal fusion, and relates to the problem that in the coronary artery lesion detection technology, the existing method is difficult to effectively utilize retinal vessel markers and realize multi-modal feature fusion detection. Coronary artery lesion is a main cardiovascular disease threatening human health, and early diagnosis is of great significance. Traditional detection depends on contrast examination and has the limitations of trauma, high cost and the like. The retinal blood vessel reflects the microcirculation state of the whole body, and a new way is provided for non-invasive detection by combining clinical indexes. The invention provides a coronary artery lesion detection method based on fusion of retinal vascular marker concept perception and multi-mode. The method has the advantages that (1) markers such as blood vessel density and curvature are calculated, and retinal blood vessel morphology is quantified; and (2) image features and clinical features are fused through a cross-modal attention aggregation mechanism, so that coronary artery disease diagnosis performance is improved. The method can be used for auxiliary detection of coronary artery lesions.

The invention discloses blood-activating and stasis-removing massage cream and a preparation method thereof, and belongs to the technical field of daily chemical products. According to the massage cream capable of promoting blood circulation and removing stasis, active substances including caffeine, a ginger root extract, heparin sodium, oldenlandia diffusa, a pseudo-ginseng root extract, a carthamus tinctorius TINCTORIUS extract, a palmata pedunculata PALMATA extract and vanillyl butyl ether are added, and after the massage cream is smeared to a body for massage, the effects of moistening skin, removing stasis and promoting blood microcirculation can be achieved, so that the skin is healthier.

The invention relates to the technical field of probiotic beverages, in particular to a hirudin peptide probiotic beverage with a vascular scavenger function, which is prepared from the following components in percentage by mass: 1 to 10 percent of hirudin peptide, 0.1 to 5 percent of probiotics, 2 to 5 percent of prebiotics, 1 to 5 percent of fruit juice, 0.1 to 2 percent of vitamin, 0.1 to 1 percent of mineral substance, 0.5 to 2 percent of dietary fiber, 0.1 to 1 percent of natural extract, 0.1 to 1 percent of sweetening agent, 0.01 to 0.1 percent of preservative and 70 to 90 percent of water, the hirudin peptide in the beverage serves as a core component of the beverage, has remarkable anticoagulation and thrombolysis effects and can activate a fibrin dissolution system in blood and inhibit the activity of thrombin, so that thrombosis is effectively prevented and treated, the occurrence risk of cardiovascular and cerebrovascular events is reduced, and the hirudin peptide can also expand blood vessels, increase blood flow and promote blood circulation. Microcirculation is improved, the symptoms of palpitation, chest distress, paralysis of hands and feet, dizziness and headache can be relieved, and blood circulation and thrombosis resistance are improved.

The invention discloses a dark circle fading composition containing a golden camellia extract as well as a preparation method and application of the dark circle fading composition, and relates to the technical field of cosmetics. The composition comprises a component A, a component B and a component C, the component A comprises a common andrographis herb extract and a golden camellia extract; the component B comprises ubiquinone and a saffron crocus extract; and the component C is menthol lactate. The herba andrographitis extract, the camellia nitidissima extract, the ubiquinone, the saffron crocus extract and the menthol lactate are combined and found to have a synergistic interaction effect, and the composition formed by the components through specific compatibility can promote blood microcirculation, inhibit microangiogenesis, increase epidermal thickness and relieve cell hypoxia and eye fatigue; moreover, the eye cream is mild and non-irritating to the skin, and is suitable for people with sensitive skin to use.

The invention belongs to the technical field of biochips, and relates to a blood vessel microcirculation chip and system for in-vitro three-dimensional tissue. The blood vessel microcirculation chip of the in-vitro three-dimensional tissue comprises a chip shell component with a culture tank, an in-vitro three-dimensional tissue is arranged in the culture tank, and the in-vitro three-dimensional tissue comprises a matrix, cells in the matrix and a microcirculation vessel network in the matrix; the microcirculation vessel network in the matrix comprises a bionic artery, a bionic vein and a self-development capillary network in the matrix. The in-vitro three-dimensional tissue blood vessel microcirculation chip and system provided by the invention have bionic artery, bionic vein and capillary networks similar to organisms, and simulate the blood vessel microcirculation process of arterial high-pressure exudation mass transfer and oxygen transfer and vein low-pressure reflux metabolism.

The invention discloses a nutritional food capable of improving a night vision function and a preparation method of the nutritional food. The composition is prepared from anthocyanin-sterculia nobilis acid nano-particles, fucoxanthin-vitamin A-resveratrol nano-particles and zinc taurate. The functions of retinal rod cells can be remarkably improved, the blood microcirculation of eyes can be promoted, and the vision sensitivity and the asthenopia resistance in dark environments such as night, weak light and low visibility can be remarkably improved; the product can be prepared into capsules, tablets, electuary, oral liquid or beverage.

The invention is suitable for the technical field of bio-photonics, and provides a capillary refilling time self-adaptive measurement system and method, and the system comprises a negative pressure adsorption module, a step release module, a modulation module, a detection module, a demodulation module, a signal processing module and a main control unit. Standardized microcirculation stimulation is realized through negative pressure adsorption and step release; adopting a frequency domain modulation and demodulation technology to obtain the phase and the amplitude of the optical signal, and inverting an absolute absorption coefficient and a reduced scattering coefficient by utilizing a frequency domain diffusion equation; and selecting an absolute absorption coefficient under equal absorption point wavelength as a blood volume index, fitting a recovery curve through a system identification model, and calculating to obtain self-adaptive capillary refilling time. According to the collaborative scheme, the problems that in the prior art, stimulation is not standard, the result is greatly influenced by skin color and temperature, and absolute parameter support is lacked are solved, and objective and accurate measurement which is high in repeatability, cross in skin color and resistant to environmental interference is achieved.