142 results about "Microcirculation" patented technology

The invention discloses a pressure injury risk early warning method and equipment, and relates to the technical field of medical monitoring instruments. The pressure sensor array layout can be self-adaptive to the body shape of a patient, a key osseous process part is covered, no monitoring dead angle is ensured, a temperature compensation mechanism is built in, environmental interference is reduced, the measurement precision is improved, an abnormal pressure threshold value can be dynamically set based on individual medical record data, data verification is performed before early warning is triggered, false alarm is avoided, and the array structure is light, thin and flexible. The mask is comfortable to fit skin, supports long-term wearing and is easy to disinfect and maintain; environment temperature and humidity parameters and pressure data are subjected to fusion analysis, the influence of a high-temperature and high-humidity environment on skin microcirculation can be recognized, the risk of pressure sores can be evaluated in an auxiliary mode, a calibration algorithm is built in a sensor, environment fluctuation interference is reduced, and data reliability is ensured; and the early warning unit comprises sound-light alarm equipment which supports a multi-stage alarm mode and is used for triggering an early warning signal and pushing information when the risk index exceeds a threshold value, so that the early warning timeliness is ensured and the false alarm risk is reduced.

The invention provides a real-time processing method for endoscopic image blood vessel enhancement and microcirculation evaluation, which comprises the following steps of: processing an original endoscopic image, and locally enhancing a brightness channel through a contrast-limited adaptive histogram equalization technology; self-adaptive frequency domain-space domain decomposition is realized based on local texture complexity analysis; performing multi-scale Hessian matrix blood vessel detection on the low-frequency component; applying a directional Gabor filter bank to the high-frequency component; spatial-temporal feature fusion is realized through multi-resolution pyramid optical flow calculation; synchronously completing blood vessel probability prediction, blood vessel diameter estimation and blood flow direction prediction by using a lightweight multi-task deep learning network; the blood flow velocity is analyzed and calculated based on a speckle mode, the perfusion density is subjected to accelerated statistics through an integrogram, and vascular morphological parameters are extracted by adopting an improved skeleton algorithm. According to the invention, an enhanced blood vessel visualization effect and a real-time microcirculation quantitative evaluation function can be provided, and the overall improvement of the endoscope image processing quality and efficiency is realized.

The invention discloses a hematopoietic preparation for treating androgenetic alopecia and a preparation method of the hematopoietic preparation. The hematopoietic preparation is prepared from 5-30 parts of radix polygoni multiflori preparata, 5-30 parts of wine ligustrum lucidum ait, 5-30 parts of mulberry, 5-30 parts of eclipta, 5-30 parts of radix paeoniae alba, 5-30 parts of astragalus membranaceus and 5-30 parts of rhizoma cibotii. The medicine composition and the specific dosage are obtained through a large number of experimental screening and clinical medication experience screening. The whole formula takes tonifying liver and kidney and benefiting essence and blood as the monarch, and takes tonifying spleen and qi and removing heat to cool blood as the minister and assistant, based on the traditional Chinese medicine theory that essence is stored in kidney and is warmed on hair, by inhibiting DHT generation, resisting hair follicle apoptosis and improving scalp microcirculation, the traditional Chinese medicine composition has the remarkable effect of treating androgenetic alopecia, is weak in toxic and side effects, and can be prepared into various clinical dosage forms.

The invention discloses an intracranial anterior artery circulation functional evaluation method and device, computer equipment and a storage medium, and relates to the field of vascular function evaluation, and the method comprises the steps: based on an intracranial angiography image and near-end pressure data, carrying out the five working processes of data input, blood vessel segmentation and segmentation, boundary condition calculation, hemodynamic simulation and functional parameter calculation; according to the method, functional parameters verified in the coronary artery field are migrated to intracranial blood vessel evaluation without additional equipment, the clinical problem that traditional morphological evaluation is not matched with functionality is solved, individualized function quantification is achieved by integrating blood vessel morphological characteristics and hemodynamic simulation, and the method is suitable for being applied to intracranial blood vessel evaluation. According to the method, an objective basis is provided for cerebrovascular disease diagnosis and treatment, the intracranial vascular disease is promoted to be converted from anatomy orientation to function orientation, the clinical decision accuracy is remarkably improved, popularization and application of functional evaluation in the field of neural intervention are accelerated, and construction of a cerebrovascular disease accurate diagnosis and treatment system is assisted.

The invention relates to the technical field of intraoperative intelligent monitoring, and particularly discloses a spinal canal debonding method and system for real-time state evaluation, and the method comprises the steps: collecting neural structure microcirculation blood flow data in real time through integrating a micro-sensing unit at a working end part of a surgical instrument, and extracting blood flow oscillation frequency and capillary hematocrit parameters; performing multi-scale signal decomposition on the blood flow oscillation frequency to obtain an energy distribution parameter, and performing dynamic mode recognition on the hematocrit data to obtain a main variation characteristic value; fusing the two characteristic parameters to generate a nervous tissue vitality index; inputting the index into a pre-trained neural network for time sequence feature analysis, and outputting a graded ischemia risk early warning signal; the operation rhythm is automatically adjusted through a decision tree control mechanism based on the early warning signal, and self-adaptive regulation and control according to the state of the nervous tissue are achieved; the technical problem that the risk of neural ischemia cannot be monitored in real time in a traditional spinal canal release operation is solved, and occult nerve injury caused by asymptomatic neural ischemia can be prevented.

The invention relates to the technical field of intelligent diagnosis and treatment, and discloses an intelligent diagnosis and treatment system for dynamic risk early warning and intervention of orthopedic patients, and the system comprises a dynamic monitoring end, an intelligent grading end, a precise intervention end, a voice alarm module and a doctor's advice cooperation module. A multi-source sensor is used for continuously collecting vital signs of a patient and local microcirculation and behavior data of an affected limb in real time, and dynamic fusion analysis is carried out based on an orthopedic specialized risk model, so that early abnormal changes of deep venous thrombosis, stress injury and falling risks can be recognized in real time; the method overcomes the hysteresis quality of traditional manual intermittent evaluation and static scale, ensures the accuracy and timeliness of early warning of severe risks, and reduces clinical risks caused by untimely intervention.

The invention relates to the technical field of cosmetics, in particular to a composition for promoting skin microcirculation as well as a preparation method and application thereof, and the key point of the technical scheme is that the composition consists of the following components: rhizoma bletillae, motherwort, poria cocos, moutan bark, ginseng, peach blossom and lotus. According to the composition, the deep-eutectic solvent is combined with a micro-jet extraction technology, so that the extraction efficiency of active ingredients such as flavonoids is remarkably improved, and functional ingredients for resisting oxidation, resisting aging and promoting blood circulation are effectively reserved. According to the composition disclosed by the invention, the comprehensive effects of improving skin microcirculation, relieving dark skin color and delaying senescence are systematically realized by efficiently extracting active substances, activating a microcirculation core pathway and cooperating with coherent effects of a whitening and repairing mechanism.

The invention is suitable for the technical field of bio-photonics, and provides a capillary refilling time self-adaptive measurement system and method, and the system comprises a negative pressure adsorption module, a step release module, a modulation module, a detection module, a demodulation module, a signal processing module and a main control unit. Standardized microcirculation stimulation is realized through negative pressure adsorption and step release; adopting a frequency domain modulation and demodulation technology to obtain the phase and the amplitude of the optical signal, and inverting an absolute absorption coefficient and a reduced scattering coefficient by utilizing a frequency domain diffusion equation; and selecting an absolute absorption coefficient under equal absorption point wavelength as a blood volume index, fitting a recovery curve through a system identification model, and calculating to obtain self-adaptive capillary refilling time. According to the collaborative scheme, the problems that in the prior art, stimulation is not standard, the result is greatly influenced by skin color and temperature, and absolute parameter support is lacked are solved, and objective and accurate measurement which is high in repeatability, cross in skin color and resistant to environmental interference is achieved.

The application discloses a kind of solid teeth pain-relieving and inflammation-clearing traditional Chinese medicine composition, it is related to traditional Chinese medicine product technical field.The composition is composed of gypsum, raw rehmannia, coptis, talc, ocher, radix cyathulae and salvia miltiorrhiza seven raw medicinal materials, wherein gypsum, raw rehmannia are monarch drug, clear and purge stomach fire, cool blood and nourish yin;Coptis, talc are ministerial drug, clear heat and dry dampness, lead heat down;Ocher, radix cyathulae are auxiliary drug, heavy town counteract, lead fire down;Salvia miltiorrhiza is servant drug, promote blood circulation and remove blood stasis, promote tissue repair.Modern pharmacological research shows that each drug of the present party has the effects of anti-inflammatory, analgesic, antibacterial, improving microcirculation and protecting periodontal tissue etc.Clinical observation shows that the pain of most patients caused by stomach fire attacking upward, gum redness and swelling, burning pain, bleeding is significantly reduced after taking 1-2 doses, redness and swelling gradually subside.Compared with existing Chinese patent medicines, the present application is simple in prescription, low in cost, has the dual effects of rapid pain relief and long-term tooth fixation, and is especially suitable for patients with recurrent toothache and early periodontitis.

The invention belongs to the technical field of diabetic foot clinical path management, and discloses a diabetic foot patient path management method and system based on lower limb vasculopathy grading. Mapping the ulcer position to the corresponding perfusion area and the artery segment to generate ulcer space characteristics; calculating a blood supply risk score of the perfusion area and generating a space risk map by combining the blood vessel image detection data and the microcirculation detection data; then collecting time sequence data including an ulcer index, an infection index, a blood supply index and a space risk map, and predicting the progress speed and the risk level of the future ulcer course; and finally, according to the blood supply risk score and the disease course prediction result, generating an individualized path management scheme through a joint triggering rule. According to the invention, precise and dynamic management of the diabetic foot ulcer is realized, the healing rate is improved, and the recurrence rate and the medical cost are reduced.

The application relates to the technical field of medical devices, in particular to a rear-end cover sealing and waterproof structure of a microcirculation imaging device. The rear-end cover sealing and waterproof structure comprises a cylindrical shell with a rear-end opening, an inner cover and an outer cover. The inner cover is embedded into the shell from the rear-end opening of the shell and is fixedly connected with one end of an inner support of the shell. The outer edge of the inner cover is attached to the inner surface of the shell, and a groove is arranged on the outer edge of the inner cover for mounting a sealing rubber ring. A first protruding ring is arranged on the outer end surface of the inner cover. A second protruding ring and a third protruding ring are arranged on the inner end surface of the outer cover. The ring surface of the second protruding ring is attached to the inner surface of the shell, and the third protruding ring is fixedly connected with the first protruding ring through screw threads. The outer edge of the inner cover is attached to the inner surface of the shell, and a groove is arranged on the outer edge of the inner cover for mounting a sealing rubber ring, so that the sealing rubber ring is tightly attached to the inner surface of the shell, and water is prevented from entering the shell from the gap between the outer edge of the inner cover and the inner surface of the shell.

The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for relaxing muscles, stimulating blood circulation and dredging collaterals and a preparation method and application thereof. Comprising the following raw materials in parts by weight: 10-18 parts of angelica sinensis, 22-30 parts of ligusticum wallichii, 10-18 parts of safflower carthamus, 10-18 parts of peach kernel, 10-18 parts of radix achyranthis bidentatae, 22-30 parts of earthworm, 10-18 parts of cassia twig and 22-30 parts of fructus psoraleae. Through the synergistic effect of the angelica sinensis, the ligusticum wallichii, the safflower, the peach kernel, the radix achyranthis bidentatae, the earthworm, the cassia twig and the fructus psoraleae, the traditional Chinese medicine has the effects of promoting blood circulation to remove blood stasis, relaxing tendons and dredging collaterals, dispelling wind and eliminating dampness, and relieving swelling and pain; modern pharmacological studies show that the prescription can improve local microcirculation, inhibit release of inflammatory factors, regulate immune response and promote repair of damaged tissues, so that the treatment targets of relieving pain and recovering functions are achieved.

The invention belongs to the field of biological medicine, and particularly relates to a traditional Chinese medicine composition for treating xerophthalmia and relieving asthenopia and a preparation method thereof, the traditional Chinese medicine composition comprises mulberry leaf, chrysanthemum, cassia seed, wolfberry, rehmannia, dogwood, moutan bark, Chinese yam, lily, poria cocos, rhizoma alismatis, dendrobe, Chinese angelica, marigold, blueberry, lycium ruthenicum, raspberry, lutein ester and bear gall gold powder. Through the scheme, the traditional Chinese medicine composition provided by the invention can effectively treat clinical symptoms of xerophthalmia, increase tear secretion, improve fundus microcirculation and increase ciliary muscle blood flow, thereby eliminating asthenopia symptoms and improving eyesight.

The invention discloses a traditional Chinese medicine tea drink for preventing and treating oral mucosa diseases and a preparation method of the traditional Chinese medicine tea drink. The traditional Chinese medicine tea drink is prepared from 10-15 parts of radix astragali, 8-12 parts of radix codonopsis, 6-10 parts of radix salviae miltiorrhizae, 5-9 parts of radix angelicae sinensis, 3-6 parts of fructus psoraleae, 6-9 parts of rhizoma polygonati, 6-9 parts of radix adenophorae, 6-10 parts of rhizoma atractylodis macrocephalae, 5-9 parts of radix ophiopogonis, 3-5 parts of radix glycyrrhizae, 4-6 parts of pericarpium citri reticulatae and 5-8 parts of herba taraxaci. Aiming at the core pathogenesis of low immunity, long-term deficiency, long-term deficiency and kidney-yang insufficiency of patients suffering from oral mucosa diseases, qi tonifying, blood activating and kidney-qi strengthening are taken as a core treatment method, the formula is scientific and reasonable, all the medicinal materials act synergistically, the overall immune function of the body is adjusted, T lymphocyte subpopulation imbalance and cell factor network disorder are improved, and the curative effect is good. The oral mucosa microcirculation is improved, local inflammation is relieved, the immunity of a patient is improved fundamentally, the recurrence rate of oral mucosa diseases is reduced, and the problems that an existing tea drink is not high in pertinence and limited in curative effect are solved. The tea drink is appropriate in taste, good in compliance, high in safety and suitable for people with various oral mucosa diseases and low immunity.

This invention relates to the field of medical device technology, and more particularly to an intelligent probe patch for monitoring blood circulation in microscopic free flaps, comprising: a disposable probe patch configured to be attached to the surface or edge of the free flap; a biocompatible adhesive layer is provided on the bottom surface of the flexible base of the disposable probe patch, and an auxiliary structure is provided on the top of the flexible base to resist postoperative tissue activity or secretions; the disposable probe patch integrates an optical sensing unit and a temperature sensing unit for collecting local blood oxygen saturation, pulse rate, and surface temperature of the flap, respectively; a repeater, establishing non-contact near-field coupling with the disposable probe patch, the repeater being configured to provide working power to the disposable probe patch through near-field coupling, enabling it to operate without a built-in battery; and synchronously receiving physiological parameter data reflecting the local microcirculation status of the flap collected by the disposable probe patch; and a terminal device, wirelessly connected to the repeater, receiving and processing the physiological parameter data.

The application discloses a tongue fur and finger end microcirculation combined detection device based on multispectral fusion. The device synchronously applies multi-band optical excitation to the tongue detection area and the finger end detection area through an excitation unit, forming a multispectral excitation sequence; a collection unit obtains the reflection, absorption and scattering response of the tongue under different spectral excitation conditions, generating a tongue multi-layer spectral response data set; a response unit collects the deep optical interference and polarization change of the finger end, and extracts a finger end microcirculation dynamic parameter set; a modeling unit constructs a cross-tissue feature constraint relationship between the tongue tissue response and the finger end microcirculation response, and generates a joint feature constraint vector; a generation unit performs joint mapping calculation on the tongue multi-layer spectral response data set and the finger end microcirculation dynamic parameter set under the limitation of the joint feature constraint vector, and outputs a constitution type identifier and a constitution stability evaluation index, so that the collaborative constraint of multi-site physiological information and reliable constitution determination are realized.

This invention discloses a kidney-tonifying and blood-activating traditional Chinese medicine composition and its application in improving postoperative visual function, belonging to the field of pharmaceutical technology. The kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is made from 10 parts of Cuscuta chinensis, 15 parts of Broussonetia papyrifera fruit, 18 parts of Lycium barbarum, 15 parts of Leonurus japonicus, 20 parts of Leonurus japonicus, 10 parts of Ligusticum chuanxiong, 9 parts of Prunus persica kernel, 6 parts of Carthamus tinctorius, 15 parts of Poria cocos, 18 parts of Albizia julibrissin bark, 12 parts of Astragalus membranaceus, and 12 parts of Pueraria lobata root. It can be standardized and adjusted according to clinical complications. This invention focuses on the critical point of "kidney deficiency and blood stasis" one month after posterior scleral reinforcement surgery, using the principles of tonifying the liver and kidneys and activating blood circulation to improve ocular microcirculation, enhance and stabilize vision, thereby protecting visual function, and conforming to the treatment principle of "treating the root cause when the condition is mild."

The invention discloses a traditional Chinese medicine composition for treating skin nodules and application thereof. The invention provides a novel traditional Chinese medicine formula for treating skin nodules and an external preparation prepared on the basis of the traditional Chinese medicine formula, which has a remarkable nodule dispersing effect, reduces the number of skin nodules, reduces the size of the skin nodules, improves the red and swollen skin, improves the microcirculation of the skin, reduces the inflammatory response of the skin, improves the oxidative stress of the skin, and has a remarkable anti-inflammatory effect. The collagen synthesis of the skin is promoted, the use is convenient, and a new technical choice is provided for the development of clinical medicines and cosmetics.

The invention discloses a cerebrovascular reactivity evaluation method for non-invasive calculation of a breath-holding index, and belongs to the field of hemodynamics numerical calculation and multi-scale modeling. The method comprises the following steps: constructing a one-dimensional (1D) arteriole hemodynamic model based on an allotactic scale law; constructing a main artery three-dimensional (3D) model, and coupling the main artery three-dimensional (3D) model with the arteriole one-dimensional model and the microcirculation zero-dimensional (0D) model to form a whole-brain 3D-1D-0D geometric multi-scale hemodynamic model; based on blood flow related data obtained in the experiment process, parameterization description is conducted on arteriole radius changes and microcirculation resistance changes; a breath holding index (BHI) is calculated by numerical solution of the geometric multi-scale model. According to the method, the non-invasive numerical calculation of the breath-holding index can be realized without directly implementing a breath-holding experiment or an external stimulation condition, and a stable and repeatable calculation means is provided for quantitative analysis and related engineering application of cerebrovascular hemodynamic behaviors.

The application discloses a composition for lightening dark circles under eyes containing camellia chrysantha extract and a preparation method and application thereof, and relates to the technical field of cosmetics.The composition comprises component A, component B and component C;the component A comprises andrographis paniculata extract and camellia chrysantha extract;the component B comprises ubiquinone and safflower extract;and the component C is menthol lactate.The andrographis paniculata extract, the camellia chrysantha extract, the ubiquinone, the safflower extract and the menthol lactate are combined to have a synergistic effect; the composition formed by the specific combination of the components can promote blood microcirculation, inhibit microvascular generation, increase epidermal thickness, relieve cell hypoxia and eye fatigue, reduce blood vessel type dark circles, relieve redness and strengthen skin, and is mild and non-irritating to skin, and is suitable for people with sensitive skin.

The invention relates to the technical field of rehabilitation evaluation, and discloses a fracture and complication integrated synchronous intervention rehabilitation treatment evaluation system, which comprises a sensing array, a reference sensing node and an evaluation unit, and is characterized in that the sensing array is arranged on an affected side limb and comprises an impedance monitoring electrode and a heat flow sensing unit; the reference sensing node is used for acquiring a system metabolism reference parameter, the evaluation unit establishes a synchronous acquisition trigger reference according to characteristic offset of interface capacitance along with a load, normalizes a heat flux density relative to the system metabolism reference parameter, calculates a response characteristic value representing microcirculation remodeling capability, identifies a blood vessel backflow state, and evaluates the blood vessel backflow state. Physical level synchronization of physiological signals and load excitation is achieved through interface polarization response, compensatory gait interference is counteracted, blood deposition and tissue effusion are distinguished, and a real-time safety boundary is provided for a rehabilitation scheme.

The invention belongs to the field of medical blood purification instruments, and discloses a selective activated leukocyte adsorber, which is used for solving the problems that a film layer of an existing adsorber is easy to deform, the blood flow is uneven, the activated leukocyte adsorption efficiency is low and the assembly safety is poor. According to the adsorber, a three-layer preassembly is formed by a flow guide net and a selective activated leukocyte adsorption film, wherein the thickness of the flow guide net is matched with the mesh diameter of a blood cell amoeba motion; a cylindrical winding body containing a radial repeated circulation unit is formed by clamping and winding the core rod I and the core rod II in a non-adhesive mode, and the cylindrical winding body is matched with a multi-blood input / output pipeline extending in the axial direction and is packaged through a shell with a sealing end cover and a sealing ring. The flow guide net can support the membrane layer, guide blood to be uniformly distributed, construct a cell microcirculation environment and improve the adsorption efficiency; the double-core-rod glue-free fixing and shell sealing design ensures the assembly safety and the structural stability, and is suitable for selectively removing activated white blood cells in clinical blood purification and assisting in treatment of inflammation-related diseases.

The present application relates to the technical field of medical image processing, in particular to a real-time monitoring and early warning system for the circulation state image of a cardiovascular surgery patient, comprising a video acquisition module, an image preprocessing module, a microcirculation evaluation module, a multi-site perfusion fusion module based on differential manifold, a trend prediction and early warning module, and a clinical interaction and data integration module; the video of the patient's fingernail bed and lips is simultaneously acquired by a high-frame-rate camera, and after preprocessing, the local perfusion index and pulsatility stability index are extracted; innovatively, the multi-site microcirculation signals are mapped onto the differential manifold for representation; through the time-frequency dual-channel fusion driven by Riemann geometry and the attention weighting mechanism, the whole-body perfusion comprehensive index is integrated; and based on the dynamic system modeling on the manifold, early warning can be provided before the conventional blood pressure significantly decreases, valuable time is won for clinical intervention, the non-invasive monitoring method avoids invasive complications, and whole-process continuous monitoring can be realized.

The application belongs to the technical field of medicine, and particularly relates to a muscone derivative, a preparation method and application thereof. The muscone derivative cyclopentadecanedione monoxime has obvious advantages over muscone and other derivatives in improving the MCAO rat mNSS score, microcirculation blood flow, reducing the cerebral infarction rate, the cortical and hippocampal neuron necrosis rate, and the brain water content, and increasing the SOD and CAT contents of the rat brain tissue which are abnormally reduced due to ischemia, and is a potential effective drug for cerebral ischemia-reperfusion injury.

This invention discloses a real-time visualization monitoring device for microcirculation blood flow, comprising a deep signal acquisition module, a blood flow dynamic acquisition module, an active calibration module, a signal extraction module, and a visualization display module. The deep signal acquisition module acquires mixed light signals from the target tissue region and extracts the signal amplitude. The blood flow dynamic acquisition module acquires a sequence of original light intensity images modulated by ultrasound. The active calibration module obtains the static interference coefficient. The signal extraction module calculates the deep microcirculation blood flow index Q based on a built-in standard reference parameter set. The visualization display module combines a pseudo-color blood flow map with an eschar morphology image to generate a fused image. This invention effectively removes interference from strong scattered light from the surface layer, stably acquires true information about deep microcirculation, and effectively suppresses the artificially high influence of static noise.

The invention discloses a cardiovascular disease assessment method and system based on CT enhanced scanning examination, relates to the technical field of CT enhanced scanning, and discloses the cardiovascular disease assessment method and system based on CT enhanced scanning examination, which obtains original projection data through dynamic CT enhanced scanning, and calculates permeability function data and time delay data; a vascular wall inflammation score and a microcirculation dysfunction score are generated by using a dual-channel deep learning fusion model, so that synchronous quantitative evaluation of vascular wall inflammation activity and microcirculation functions is realized, and the vascular wall inflammation activity state and the microcirculation dysfunction degree can be synchronously quantified; therefore, the accuracy of cardiovascular disease risk assessment is improved.

The invention provides a comprehensive assessment method for coronary artery function, which comprises the following steps of: based on boundary conditions, performing hemodynamic numerical simulation calculation on each finite element model by adopting a traditional computational fluid mechanics solution mode or a reduced order solution mode to obtain simulated hemodynamic parameters; based on a comparison result between the simulated hemodynamic parameters and the reference hemodynamic parameters corresponding to each finite element model, performing iterative optimization on the outlet resistance of each blood vessel branch and the simulated hemodynamic parameters in the boundary conditions to obtain optimized outlet resistance of each target blood vessel branch and target simulated hemodynamic parameters; and determining the fractional flow reserve and the microcirculation resistance index by using the outlet resistance of each target blood vessel branch and the target simulated hemodynamic parameters. According to the method, coupling iterative calculation is carried out on the microcirculation resistance by establishing the coronary vessel tree, the microcirculation resistance index and the fractional flow reserve are determined at the same time based on the calculation result, and the reliability of overall coronary function calculation is improved.

The invention discloses eye protection liquid and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine external preparations. The eye protection liquid is prepared from a chrysanthemum extract, borneol, calculus bovis factitius, venenum bufonis, realgar, a mint extract, a pipewort extract, a feather cockscomb seed extract, a butterflybush flower extract, pearl powder and purified water according to a specific weight part ratio, and is prepared by soaking, distilling, filtering and filling. The traditional Chinese medicine composition can rapidly permeate into eyes and directly enter focus, can relieve and treat various eye diseases such as presbyopia, myopia, amblyopia, cataract and the like, has the effects of soothing liver and relieving depression, promoting blood circulation and dredging collaterals, tonifying kidney and nourishing yin, supplementing optic nerve nutrition and improving microcirculation around the eyes, has the total effective rate of 100% and the cure rate of 80-95%, and is free of side effects and drug resistance and convenient to use.

The invention relates to the technical field of biology, in particular to a method for modular assembly of artery blood vessel type organs and construction of tissue microcirculation of the artery blood vessel type organs. The method comprises the following steps: inducing human pluripotent stem cells to differentiate through a mesoderm stage to form an arterial specific vascular organoid module (AVO), and then carrying out modular assembly on the AVO in vivo or in vitro so as to quickly reconstruct a tissue microcirculation network with arterial characteristics. The obtained artery blood vessel organoid is uniform in form, the diameter of the artery blood vessel organoid is intensively distributed at about 200 microns, SOX17 and CXCR4 artery endothelial markers are expressed at the same time, and the artery blood vessel organoid has polarity and a complete basilar membrane. Transplanting experiments show that the organ can be integrated with host blood vessels in a short time, and ischemic tissue blood perfusion is recovered. The defects that existing organoid is irregular, difficult to splice, delayed in perfusion and the like are overcome, and a new strategy is provided for revascularization and acute ischemic disease repair.

The invention discloses an atropine derivative and a preparation method and application thereof, and belongs to the technical field of medical preparations, the atropine derivative and a salt or a pharmaceutical composition thereof can be used as a ciliary muscle paralysis agent and / or a mydriasis agent; the choroid and sclera functions can be regulated and controlled by improving choroid microcirculation and sclera hypoxia environment, inhibiting an HIF-1alpha signal channel and directly targeting sclera fibroblasts to inhibit extracellular matrix generation and remodeling; the medicine is used for relieving muscae volitantes symptoms; amblyopia, lazy eye diseases or myopia can be relieved; for treating or preventing myopia; the traditional Chinese medicine composition has good maintenance time and treatment effect, can obviously reduce the use frequency and use amount, improves the use experience, and reduces the medicine use cost.