14 results about "Chemoradiotherapy" patented technology

The invention discloses a special medical application formula and a preparation method of a selenium-rich ginseng medicinal and edible herbal liquid, and belongs to the technical field of health foods and special medical foods. The formula is prepared from a selenium-enriched ginseng extract, Chinese yam powder, a poria cocos extract, a gordon euryale seed extract, a Chinese date extract, a longan aril extract and auxiliary materials through scientific compatibility, and has the effects of tonifying spleen and kidney, reinforcing qi and nourishing blood aiming at the pathogenesis of spleen and kidney deficiency and deficiency of qi and blood. According to the preparation method, a gradient process combining ultrasonic-assisted ethanol extraction and enzymolysis water extraction is adopted, and active ingredients such as organic selenium, ginseng rare saponin, jujube cAMP and longan polysaccharide are efficiently extracted and reserved. Experiments show that the herbal liquid has a remarkable synergistic effect in the aspects of improving immunity, improving hematopoietic function and resisting fatigue, and is suitable for nutrition support and function conditioning of tumor chemoradiotherapy patients and postoperative weak people.

Aspects of this invention are related to the use of N-desmethyl ruboxistaurin and pharmaceutically acceptable formulations thereof to modulate RSK signaling. Some aspects of the invention relate to the use of N-desmethyl ruboxistaurin to inhibit RSK. Some aspects of the invention provide methods of using N-desmethyl ruboxistaurin in the treatment of subjects with cancer, including breast cancer, ovarian cancer, prostate cancer, lung cancer, hepatocellular carcinoma, colorectal cancer, melanoma, osteosarcoma, myeloproliferative neoplasms, leukemia, and bladder cancer. The disclosed methods extend beyond disease treatment, including supportive care during radiation chemotherapy and prevention of cancer relapse. N-desmethyl ruboxistaurin administration, alone or in combination with other cancer therapies, inhibits RSK and shows a safety profile that supports its long-term use.

The invention belongs to the technical field of biological medicines, and particularly discloses a pH and ultrasound double-response type oncolytic microorganism as well as a preparation method and application thereof. On the basis of a tumor targeting platform, a mild thermal response gene loop expression GM-CSF and a surface-coated oncolytic microbial system are integrated, chemotherapeutic drugs are released in a tumor core area, and immunogenic cell death is induced. A thermal response loop is accurately activated through low-intensity focused ultrasound, and engineering bacteria are promoted to express GM-CSF and secrete a large amount of mannose modified OMVs. Due to the nanometer size and mannose targeting of the OMVs, the OMVs are efficiently enriched in lymph nodes, the OMVs are reprogrammed into an immune activation state from an immune tolerance state, and the OMVs and ICD cooperate to promote dendritic cell maturation, tumor antigen presentation and activation of tumor killer T cells, so that a remarkable and powerful treatment effect is achieved in various tumor models, and the application prospect is wide. A new strategy is provided for remodeling the lymph node immune microenvironment and enhancing the anti-tumor immune response.

The invention discloses a traditional Chinese medicine composition for treating middle and advanced stage tumors. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 9-11 parts of ganoderma lucidum slices, 1-3 parts of radix angelicae sinensis, 1-3 parts of cordyceps militaris, 5-7 parts of poria cocos, 1-3 parts of fructus lycii, 2-4 parts of radix astragali, 5-7 parts of polyporus umbellatus, 3-5 parts of ginseng slices and 3-5 parts of exocarpium citri grandis. The traditional Chinese medicine composition has the effects of benefiting qi and nourishing blood, tonifying kidney and spleen, and supporting healthy energy. The traditional Chinese medicine is used for treating qi and blood deficiency syndromes caused by middle and advanced tumors, wherein the syndromes comprise mental exhaustion, limb weakness, body emaciation, pale complexion, inappetence and the like. The traditional Chinese medicine composition can also be used for relieving toxic and side effects after radiotherapy and chemotherapy and early treatment of cancers. The invention further discloses a method for preparing the traditional Chinese medicine composition, the dosage form advantage is remarkable, the preparation process is stable and controllable, and the method is suitable for industrial production.

The invention belongs to the field of biological medicine, and relates to degradable monodisperse embolism microspheres loaded with radionuclides and chemotherapeutic drugs and a preparation method of the degradable monodisperse embolism microspheres. The embolism microspheres are composed of degradable polymer microspheres with negative charges, radionuclides and chemotherapeutic drugs with positive charges. Radionuclides are connected to the degradable polymer microspheres through chemical bonds, and chemotherapeutic drugs with positive charges are loaded on the degradable polymer microspheres through electrostatic adsorption; the embolism microsphere is spherical, the particle size is 20-100 microns, and the variable coefficient of the particle size does not exceed 10%; the base material of the degradable polymer microspheres is formed by photo-initiation polymerization of two different photopolymerization macromolecules. The embolism microsphere provided by the invention can realize in-vivo chemoradiotherapy synergistic treatment, in-vivo development and in-vivo degradability, and has excellent monodispersity at the same time.

The devices, systems, and methods disclosed herein may be directed to a delivery system including a therapeutic member configured for endoluminal placement via the delivery system into the esophagus of the patient, wherein the therapeutic member comprises a treatment portion comprising a film for controlled release of a chemotherapeutic agent. The film may comprise a control region, a therapeutic region, and a substantially impermeable base region. The film is configured to release the chemotherapeutic agent in a direction away from the substantially impermeable base region. The delivery system is configured to enable a treatment provider to position the treatment portion of the therapeutic member proximate to a treatment site associated with the esophagus of the patient, and the therapeutic member is configured to administer a therapeutically effective dose to the treatment site for a sustained period following endoluminal placement of the therapeutic member.

The application provides a nano regulator and a preparation method and application thereof. Specifically, water regulation drugs and chemotherapy drugs are co-delivered through metal organic framework nanoparticles or metal polyphenol nanoparticles, the tumor-targeted enrichment and microenvironment-responsive release characteristics of the nano regulator are utilized to release the chemotherapy drugs at the tumor site after cryoablation. The nano regulator can be used for cryoablation sensitization and chemotherapy synergistic treatment, thereby effectively improving the tumor inhibition effect.

The present disclosure relates to methods, combinations and uses for the treatment of cervical cancer using an anti-PD-L1 binding protein or an anti-PD-1 binding protein and chemoradiotherapy.

The invention discloses application of an MARCO inhibitor combined with radiotherapy and chemotherapy in treatment of glioma. The invention creatively discovers that the MARCO inhibitor, the radiotherapy and the chemotherapy or the combined use of the MARCO inhibitor, the radiotherapy, the chemotherapy and the PD-1 inhibitor has a remarkable synergistic effect on the glioma for the first time, and the treatment effect of the combined medication mode on the glioma is remarkably superior to that of a single MARCO inhibitor or a chemoradiotherapy strategy. The advantage in treatment of glioma is obvious. The invention provides an effective drug combination strategy for treatment of glioma, and has a good clinical application prospect and important transformation significance in the technical field of research and development of glioma treatment drugs.

The invention discloses an iridium complex, a preparation method thereof and application of the iridium complex in chemoradiotherapy synergistic treatment. In the prior art, the design of systematic'combination of chemoradiotherapy and active targeting 'of iridium complexes and the report of clear mechanism-level evidence (such as gamma-H2AX, cell cycle and the like) are still limited. The invention discloses an iridium complex nano-drug and an application thereof in breast cancer chemoradiotherapy synergistic treatment, the iridium complex nano-drug has high atomic number elements and a targeting molecular nano-material, can enhance radiation energy deposition and enrich tumor tissues, and is a direction for improving radiotherapy sensitivity; the iridium complex has the characteristics of AIE performance, mitochondrial targeting, ROS production and the like, and is expected to be used as a chemotherapy sensitizer and an imaging probe.

The invention belongs to the technical field of medicines, discloses application of a salvia chinensis active ingredient composition in treatment of esophageal squamous carcinoma, discloses a medication rule for treating ESCC and an action mechanism of a core medicine salvia chinensis, enriches a theoretical system for treating ESCC by traditional Chinese medicine, and provides a new thought and a theoretical basis for subsequent in-depth study on treatment of cancer by traditional Chinese medicine. Compared with traditional radiotherapy and chemotherapy drugs, the salvia chinensis serving as a traditional Chinese medicine has lower toxic and side effects, the active ingredients of the salvia chinensis treat ESCC through a multi-target and multi-channel action mode, the tumor microenvironment can be adjusted more comprehensively, the malignant behavior of tumor cells can be inhibited, the treatment effect can be improved, and the life quality of patients can be improved. Core active ingredients and action targets of salvia chinensis for treating ESCC are defined, important material basis and action targets are provided for developing novel anti-ESCC drugs, the research and development process of related drugs is accelerated, modern development of traditional Chinese medicine is promoted, and new treatment hope is brought to ESCC patients.

The invention provides a composition for treating yin deficiency constipation and a preparation method and application thereof, and belongs to the technical field of pharmaceutical compositions. The composition for treating yin deficiency constipation is prepared from radix rehmanniae recen, radix ophiopogonis, radix glehniae, fructus cannabis, semen pruni, semen boitae, radix astragali, roasted rhizoma atractylodis macrocephalae and fructus perillae. The three monarch drugs synergistically nourish lung yin, stomach yin and kidney yin, yin fluid is supplemented from the source, and the foundation of'water increasing and boat running 'is built; the three ministerial drugs are complementary and synergistic, and lubricate intestinal tracts; astragalus mongholicus and roasted rhizoma atractylodis macrocephalae are used as adjuvant drugs to tonify qi and spleen, prevent the monarch drugs from being sweet, cold, greasy and obstructing stomach, and tonify qi and promote intestinal The traditional Chinese medicine is scientific in compatibility of the medicines, mild in medicine property, capable of giving consideration to both cold and heat and tonifying and reducing, and suitable for old people, postpartum women, weak people after long illness and patients after radiotherapy and chemotherapy.

The invention discloses an ultrasonic response type bacterial composite drug-loading system as well as a preparation method and application thereof. The system is formed by taking engineering bacteria as a carrier, grafting chemotherapy prodrug molecules on the surface of the engineering bacteria through atom transfer radical polymerization and then loading a sound-sensitive agent. Compared with the prior art, by optimizing ATRP reaction conditions, efficient grafting of the medicine on the surfaces of bacteria is achieved, and the activity of the bacteria is kept. After intravenous injection, the system is enriched at a tumor site by virtue of a tumor hypoxia targeting carrying drug of attenuated salmonella, and ultrasonic irradiation activates a sound-sensitive agent to generate active oxygen: on one hand, the active oxygen splits a TK bond in a prodrug to release a chemotherapeutic drug, and on the other hand, the active oxygen mediates sonodynamic therapy. The system solves the problems that a traditional drug delivery system is poor in targeting property, uncontrollable in drug release and limited in single treatment effect, and the ATRP technology is mild in preparation process and good in biocompatibility and has wide application prospects in the field of deep tumor targeted therapy.

The invention relates to a polyprotein peptide composition and application of the polyprotein peptide composition in the aspect of hypoproteinemia, and belongs to the field of biological medicine. The polyprotein peptide composition comprises the following components in parts by weight: 40-60 parts of ovalbumin peptide; 15 to 30 parts of fish collagen peptide; 10 to 20 parts of sea cucumber oligopeptide; 5 to 15 parts of cordyceps militaris oligopeptide; and 5 to 15 parts of yeast beta-glucan. The ovalbumin peptide is used as a core protein source, the fish collagen peptide, the sea cucumber oligopeptide, the cordyceps militaris oligopeptide and the yeast beta-glucan are compounded, the components achieve a synergistic effect according to a specific weight ratio, the A / G protein inversion state of a patient suffering from the hypoproteinemia can be rapidly improved, wound granulation tissue hyperplasia and healing are promoted, physical strength is enhanced, fatigue is resisted, and the curative effect is good. The composition can be used for treating hypoproteinemia, enhancing lymphocyte proliferation and NK cell activity, reducing side effects of chemoradiotherapy, improving the curative effect of anti-tumor treatment and remarkably improving the prognosis of patients, and can be widely applied to nutrition intervention, postoperative rehabilitation and tumor chemoradiotherapy adjuvant therapy of hypoproteinemia patients.