198 results about "Prostate" patented technology

The invention belongs to the technical field of medical image processing, and particularly relates to a prostate MRI-TRUS deformable image registration method based on structure perception decoupling learning. The method comprises the following steps: designing an anatomical maintenance intensity disturbance module, simulating intensity and artifact differences between different modes on the premise of keeping an anatomical structure unchanged, and generating diversified appearance samples to improve the adaptability of the model to mode changes; a double-flow encoder structure is constructed, space attention latent consistency loss is introduced into a multi-layer feature space, the structure consistency is restrained from the feature level, and deep structure representation learning with the unchanged appearance is achieved; and an enhanced pyramid decoder is adopted to fuse multi-scale structural features layer by layer to predict a registration deformation field, so that high-precision cross-modal alignment is realized. According to the method, structural consistency constraint is carried out on the hidden space level, so that the influence of modal difference and artifacts can be effectively reduced, and the registration precision is improved.

The present disclosure relates to the synthesis of prostate-specific membrane antigen (PSMA) ligands useful in the treatment of diseases such as cancer. In particular, the present disclosure relates to methods for synthesizing PSMA ligands having a glutamic acid-urea-lysine (GUL) moiety and a chelator that may include a radiometal.

The invention belongs to the technical field of medical image segmentation, and relates to a dual-path fusion neural network for prostate precise segmentation and a segmentation method, the neural network constructs a dual-path decoupling encoder architecture based on an nnU-Net framework, captures fine anatomical structure and local texture information through a context sensing residual encoder of a local path, and obtains a dual-path fusion neural network for prostate precise segmentation. A long-range dependency relationship is modeled with linear complexity through a visual state space module of a global path, a double-flow alignment gating module is designed to realize self-adaptive alignment and fusion of cross-path features, and model training is optimized in combination with a mixed loss function and a depth supervision strategy; according to the method, the limitation of an existing segmentation model in the aspect of local structure and global semantic integration is solved, and the segmentation precision, the boundary goodness of fit and the generalization performance of the focus and gland region in the prostate MRI image are improved.

The invention discloses a prostate MR image segmentation method and system based on multi-level context aggregation, and the method comprises the steps: segmenting a prostate MR image through a trained prostate MR image segmentation model, and obtaining a segmentation result. The model is based on an improved U-shaped architecture and comprises a multi-level coding module, a jump connection processing module, a bottleneck layer, a multi-level decoding module and a segmentation head. The multi-level coding module extracts image features of different levels, and the jump connection processing module generates enhanced features through combination of hierarchical expansion convolution and an improved Transform architecture; the bottleneck layer decouples the bottom layer features into foreground / background features, and outputs a feature map through local window attention weighted fusion; and the multi-level decoding module gradually recovers the resolution through residual convolution and bilinear up-sampling, and finally outputs a binary segmentation result through a segmentation head. According to the method, the accuracy and robustness of prostate MR image segmentation are improved through hierarchical feature aggregation and attention fusion.

The invention discloses a prostate segmentation method fusing multi-scale attention, and relates to the technical field of medical image processing, and the key points of the technical scheme are that a feature extraction unit in the method is composed of three parts of convolution-attention-convolution: initial convolution is used for extracting input high-order features; then, an introduced attention module extracts multi-level context information through a plurality of convolutional networks with different scales, and redundant features are screened in combination with a gating mechanism, so that key information is reserved; and the final layer of convolution performs fine adjustment on the fused features. In order to further improve the fusion effect, a feature reconstruction strategy based on a self-attention mechanism is also introduced in the scheme, so that the model can fully understand and integrate multi-scale information, and the robustness of the model is improved while the segmentation precision is ensured.

The invention discloses a tiny focus recognition method for prostate puncture and application, and the method comprises the steps: S1, collecting and preprocessing an MRI image and an ultrasonic image of a patient, and obtaining a preprocessed MRI image and a preprocessed ultrasonic image; s2, constructing a texture attention residual network, and extracting MRI texture enhancement features; constructing a multi-scale edge response gating network, and extracting ultrasonic edge enhancement features; s3, performing spatial transformation and resampling on the ultrasonic edge enhancement features to obtain aligned ultrasonic enhancement features; s4, calculating a focus area weight feature matrix, an MRI dynamic weight matrix, an ultrasonic dynamic weight matrix, redundancy-removed MRI features, redundancy-removed ultrasonic features and tiny protection features; and S5, identifying the tiny focus area, and controlling the puncture robot to puncture. The problems that a traditional method is poor in tiny focus recognition capacity, missed diagnosis of the focus is prone to occurring, and puncture accuracy is insufficient can be solved.

A transperineal biopsy guide for use with an access needle and a transrectal imaging probe. The transperineal biopsy guide includes a mount, a guide member, and an access needle support structure. The mount is attachable to the probe. The guide member includes: a first side comprising a first distal member and a first surface extending proximally from the first distal member; a second side comprising a second distal member and a second surface extending proximally from the second distal member; and a gap between the first distal member and the second distal member. The access needle support structure is securable to the guide member in a distal position that inhibits vertical and distal displacement of the access needle support structure relative to the guide member while permitting disengagement from the distal position via proximal movement of the access needle support structure relative to the guide member.

Methods and compositions for treatment of prostate cancers, such as androgen receptor (AR) deficient and androgen receptor (AR) low cancers, are disclosed. The methods include administration of an agent that inhibits activity of eIF4F or an agent that disrupts the eIF4F translation-initiation complex (composed of eIF4E, eIF4A, and eIF4G).

1. The name of the design product: red light therapeutic instrument (prostate). 2. The use of the design product: for red light therapy. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

The invention provides a prostate cyst excision device based on ultrasonic guidance, and belongs to the technical field of medical instruments. Comprising a mounting plate mounted on an operating bed, a first positioning plate is fixedly connected to the top of the operating bed, a second positioning plate is slidably connected to the top of the first positioning plate, and a third positioning plate is slidably connected to one side of the second positioning plate; the ultrasonic probe and the resectoscope are installed on the first positioning plate and the third positioning plate respectively. By arranging the positioning assembly, the efficiency of medical staff for placing the ultrasonic probe and the resectoscope into the body of a patient can be improved, the positioning assembly can open a wide operation channel in the rectum of the patient, the convenience of placing the ultrasonic probe into the body of the patient is improved, the operation view is wider, and the operation efficiency is improved. And the positioning assembly can clamp and fix the glans penis of the patient, so that the efficiency of placing the resectoscope into the urethra of the patient is further improved.

The invention discloses a robot-assisted prostate radical treatment special-purpose blood vessel drag hook apparatus, which comprises a drag hook part, and is characterized in that the drag hook part comprises a cross rod and a first connecting rod; the two ends of a rod body of the transverse rod are symmetrically connected with the tail ends of rod bodies of arc-shaped rods correspondingly. The two ends of a rod body of the first connecting rod are fixedly connected with the head ends of rod bodies of the two arc-shaped rods into a whole correspondingly. One end of a rod body of the straight connecting rod is fixedly connected with the middle section of the rod body of the cross rod into a whole; and the holding handle is coaxially connected with the other end of the rod body of the straight connecting rod. The condition that blood vessels are damaged when blocked can be reduced, the success rate of blood vessel blocking operation is increased, and the operation efficiency is optimized.

The present disclosure relates to a prostate image-based evaluation method, device, equipment, medium and product, the method comprising: acquiring first image data of a prostate target area matched with a structure evaluation model, the structure evaluation model comprising a structure morphology network and a structure evaluation network; performing feature extraction on the first image data through the structure morphology network to obtain morphology feature data, the morphology feature data representing quantitative information of a structure morphology of the prostate target area; and performing structure evaluation according to the morphology feature data through the structure evaluation network to determine structure evaluation data of the prostate target area. The present embodiment solves the problem of insufficient accuracy of an artificial evaluation mode, guarantees the objectivity and repeatability of prostate evaluation tasks, and provides assistance for promoting the standardization iteration of prostate intervention technology.

The invention discloses a drug-coated prostate balloon dilatation catheter control system, relates to the technical field of medical instruments, and aims to solve the technical problems of uncontrollable drug release, extensive dilatation process and lack of quantitative evaluation in existing drug balloon therapy. The system integrates a high-precision pressure sensing module, a micro piezoelectric pump control module, a man-machine interaction module and a data processing module. The system carries out real-time closed-loop control on the internal pressure of the balloon through a self-adaptive PID algorithm, and precise execution of a preset pressure curve is achieved. The innovation of the method lies in that a drug release quantitative estimation model based on pressure-time integration (AUC) is created for the first time, the model can calculate and display the estimated drug release amount in the treatment process in real time, and physical operation parameters are directly associated with biological effects; the device has the effects of realizing accurate and constant control of the dilatation pressure and improving the operation safety.

Disclosed herein are isolated polypeptide and polypeptide complex compositions that comprise a prostate-specific membrane antigen (PSMA) binding domain that is linked to a peptide that impairs binding of the PSMA binding domain to PSMA.

An inhibitor of a prostate specific membrane antigen and a pharmaceutical use thereof. Specifically, the present solution belongs to the field of radiopharmaceuticals and relates to a compound represented by formula (IV) or a pharmaceutically acceptable salt thereof.

The present disclosure provides methods for treating prostate cancer or metastatic castration-resistant prostate cancer, reducing the severity of prostate cancer or metastatic castration-resistant prostate cancer, or inhibiting the growth of prostate cancer or metastatic castration-resistant prostate cancer. The methods of the present disclosure comprise administering to a subject in need thereof a therapeutically effective amount of a bispecific antibody, or antigen-binding fragment thereof, that specifically binds to prostate specific membrane antigen (PSMA) and CD28, as a monotherapy or in combination with an anti-PD1 antibody.

A transperineal biopsy guide for use with an access needle and a transrectal imaging probe. The transperineal biopsy guide includes a mount, a guide member, and an access needle support structure. The mount is attachable to the probe. The guide member includes a guide member extending from the mount and including a first extension member and a first guide rail extending from the first extension member. The first extension member including a first distal edge extending upwardly and distally relative to the distal surface of the mount. The first guide rail including a first guide rail distal end, a first guide rail proximal end opposite the first guide rail distal end, and a first distal member that is distally and vertically offset from the mount. The access needle support structure engageable with the first guide rail and slidable in a distal-proximal direction relative to the first guide rail.

This invention provides a combination for use in treating cancers that express prostate-specific membrane antigen (PSMA). [Solution] A combination comprising a PD-1 inhibitor, a CTLA-4 inhibitor, and a radiolabeled compound of formula Ia for use in treating PSMA-expressing cancer in the subject. JPEG2026049728000042.jpg45132 The aforementioned combination comprises one or more further anticancer agents, wherein the further anticancer agents are selected from octreotide, lanreotide, vapreotide, pasireotide, satreotide, everolimus, temozolomide, telotristat, sunitinib, sulfatinib, ribociclib, entinostat, and pazopanib.

The present invention discloses a complex comprising (a) a compound, which is CA007 *, CA008 *, or CA009 *, or a pharmaceutically acceptable salt thereof, and (b) a radionuclide, which is selected from the group consisting of 203Pb and 212Pb. Also disclosed is the use of said complexes in the manufacture of a medicament for the treatment of cancers expressing prostate specific membrane antigen (PSMA). (CA007 *) (CA008 *) (CA009 *)

The present invention relates to a method and apparatus for transperineal prostate biopsy. In one embodiment, the apparatus for transperineal prostate biopsy includes: (a) a first parallel mechanism for generating translational or rotational motion of an ultrasound probe; (b) a series-parallel hybrid mechanism as an end effector of the first parallel mechanism for accommodating the ultrasound probe and a biopsy needle guide; (c) a drive module of the series-parallel hybrid mechanism for generating rotational and translational motion of the ultrasound probe along an axis of the ultrasound probe; (d) a second parallel mechanism of the series-parallel hybrid mechanism for controlling the configuration of the biopsy needle guide relative to the ultrasound probe and constraining the trajectory of the biopsy needle to an axial imaging plane of the ultrasound probe; and a controller for performing kinematic modeling.

The invention discloses an integrated guide control method for a prostate dilation catheter, relates to the technical field of medical treatment, solves the problem of highly integrating two core links of'guide 'and'control' in an operation, and realizes simplification of operation, accuracy of positioning and controllability of mechanical parameters, so that the treatment effect is ensured, and the operation cost is reduced. According to the technical scheme, the method is characterized by comprising the following steps that firstly, preoperative measurement and planning are carried out; 2, a catheter is placed in and initially positioned; 3, integrated guiding and accurate anchoring are carried out; the prostate dilation device has the advantages that the prostate dilation operation is successfully converted from a complex technology which highly depends on experience and equipment to an advanced treatment mode which is standardized, quantitative, minimally invasive and excellent in function protection through unique integrated guide and control design, and revolutionary improvement is brought to multiple dimensions of curative effect, safety, function and efficiency.

The invention discloses a composition for improving sexual life and / or prostate symptoms and a preparation method thereof. The composition is prepared from the following components in parts by weight: 30 to 50 parts of algal polysaccharides, 15 to 25 parts of phospholipid, 8 to 12 parts of euphausia superba oil, 8 to 12 parts of magnesium oxide, 8 to 12 parts of lycopene, 2 to 4 parts of zinc gluconate, 1 to 3 parts of radix ginseng extract, 0.8 to 1.2 parts of flos sophorae immaturus extract, 0.8 to 1.2 parts of fructus rubi extract, 0.8 to 1.2 parts of mulberry fruit extract, 0.8 to 1.2 parts of fructus lycii extract and 0.8 to 1.2 parts of sodium selenite. By limiting the raw materials and the dosage, under the combined action of the raw materials, the prepared composition can improve erectile, ejaculation and anterior lacrimal gland symptoms, can improve the quality of sexual life, and has no side effect on the body.

The application relates to the technical field of image processing, and discloses a method and device for prostate image fusion by adopting a posture sensor, which comprises the following steps: fixing the posture sensor on an ultrasonic probe; locking the depth position of the ultrasonic probe when the ultrasonic probe detects a prostate position; collecting ultrasonic images by rotating the ultrasonic probe; recording the rotation information of the ultrasonic probe by the posture sensor; obtaining multi-angle ultrasonic images of the prostate and corresponding posture sensor data; rotating the ultrasonic images of each angle according to the coordinate alignment rotation angle of the multi-angle ultrasonic images and the corresponding posture sensor data; obtaining a two-dimensional ultrasonic image sequence and performing interpolation processing on the ultrasonic images; and constructing a three-dimensional ultrasonic image; and fusing the nuclear magnetic image and the real-time two-dimensional ultrasonic image according to the pre-obtained nuclear magnetic image to obtain a fusion image; the application is a new method for realizing multi-modal fusion images by adopting a posture sensor.

The utility model discloses a rapid quantitative detection kit for detecting prostate small body leaked protein, which belongs to the technical field of prostate small body leaked protein detection and comprises a kit inner box, a kit outer box is arranged on the outer side of the kit inner box, and a sealing plate is arranged on the inner side of the kit outer box. According to the utility model, through the unique design of the adjusting plate, a detector can flexibly rotate the adjusting plate according to the amount of a required solution, so that the discharge port is accurately connected with the corresponding discharge chute, and when the solution is added to a position flush with the discharge chute, the redundant solution automatically flows out from the discharge port to the outer kit for temporary storage; therefore, the problem of inaccurate solution measurement caused by factors such as human visual errors or hand shaking in a traditional measurement mode is effectively avoided, high accuracy of the solution amount added each time is ensured, a solid foundation is laid for the accuracy of detection of the prostate small body leaked protein, the reliability and repeatability of a detection result are remarkably improved, and the method is suitable for popularization and application. And detection errors caused by solution amount deviation are reduced.

The invention discloses a prostate image segmentation method with a multi-granularity self-attention mechanism, and relates to the technical field of medical image processing, and the technical scheme is characterized in that the prostate image segmentation method introduces the multi-granularity self-attention mechanism behind a U-Net convolution module, builds a prostate image segmentation model, and obtains a prostate image segmentation model; according to the method, each group of convolved feature maps is subjected to branch processing, one part is used for the relationship between feature points to reduce the calculation burden, and the other part is used for calculating the relationship between each feature point and each region; finally, features obtained through reconstruction under two different granularities are fused, and local details and global semantic information are effectively combined, so that the expressive force of a prostate image model in a complex prostate image is enhanced.

Imaging and radiotherapeutic agents targeting fibroblast-activation protein-α (FAP-α) and / or prostate-specific membrane antigen (PSMA) and their use in imaging and treating FAP-α and / or PSMA-related diseases and disorders are disclosed.

A prostate-specific membrane antigen (PSMA)-targeting ligand compound and a chelate thereof and use thereof are provided. The PSMA-targeting ligand compound has a structure as shown in formula I, where R1, R2 and R4 are each independently selected from the group consisting of H and optionally substituted linear or branched C1-C5 alkyl; R3 is selected from the group consisting of optionally substituted aryl and optionally substituted heteroaryl; X is a sulfur atom or an oxygen atom; Y is selected from the group consisting of a chemical bond and —NH—(CH2)m-, where m is an integer selected from 0-18; and Z is a radioactive metal ion chelating group.

A method for imaging inflammation associated with inflammatory bowel disease (IBD) has been disclosed, which involves administering an imaging agent targeting prostate-specific membrane antigen (PSMA) to a subject and acquiring images.

Provided herein are, inter alia, methods of treating prostate cancer in a subject by administering to the subject a combination comprising i) a chimeric polypeptide targeting PSMA and CD3, and ii) an androgen receptor antagonist.