4 results about "Tumor Pathology" patented technology

The present application relates to the technical field of necrosis region segmentation, and particularly relates to a kind of automatic segmentation method of digestive tract tumor pathological image necrosis region.The present application obtains the necrosis probability of each image block according to the pixel value distribution of different pixel points in each image block and the morphological characteristics of different regions;for any image block, according to the pixel value distribution of different regions, the necrosis probability and the preset pixel fixed step, obtain the new clustering center corresponding to the cytoplasm region in each image block, and the iteration clustering of all pixel points is carried out until the preset iteration number is reached, to obtain the optimized clustering center of cytoplasm region;according to the optimized clustering center corresponding to the cytoplasm region in each image block, clustering is carried out, the new necrosis probability of each image block is analyzed, and the necrosis block is screened out for segmentation.The present application improves the accuracy of segmentation by adaptively adjusting the clustering center in the clustering algorithm.

This invention discloses a breast tumor pathology sampling device, relating to the field of medical devices. It includes an outer sampling tube and an inner sampling tube rotatably disposed within the outer tube. It also includes: a sampling mechanism for cutting and storing samples for tumor pathology; a driving mechanism for driving the inner sampling tube to rotate within the outer tube for sampling; and a negative pressure mechanism for cooperating with a sample storage chamber for tumor pathology sampling. This mechanism allows a negative pressure hose to connect to a negative pressure pump, creating a negative pressure environment within both the outer and inner sampling tubes to improve the efficiency of tumor pathology sampling. Furthermore, a storage tube can store blood from the tumor pathology sample. When the inner sampling tube absorbs the tumor pathology sample under negative pressure, the blood within the tissue is filtered and stored in the storage tube, while the tumor pathology sample is stored in the inner sampling tube. This not only efficiently and completely completes the tumor pathology sampling process but also prevents blood from affecting the tumor pathology sample.

This invention discloses a fluorine-nitrogen co-doped carbon dot, its preparation method, and its applications. The fluorine-nitrogen co-doped carbon dot is a nanoparticle constructed using a one-step hydrothermal synthesis method with fluorine-containing and nitrogen-containing precursors. The nanoparticle is spherical with a particle size of 5 nm, and its surface is rich in carboxyl, amino, and hydroxyl functional groups. Its fluorescence quantum yield is not less than 20%, and its emission wavelength is in the 500-550 nm range. It has the characteristic of targeting the H3K36me2 histone modification in tumor cell nuclei, and can achieve specific labeling of tumor cells within 5 minutes. The enrichment intensity in tumor tissue is more than 2.72 times that in normal tissue. The fluorine-nitrogen co-doped carbon dot of this invention is expected to serve as a novel fluorescent labeling probe for tumor identification and imaging, contributing to the early and accurate diagnosis of malignant tumors. It has multiple advantages such as speed, accuracy, safety, and visualization, and has broad application prospects in tumor pathology identification and intraoperative navigation.