134 results about "Precision medicine" patented technology

The invention discloses a systematic pharmacology method of personalized medication. Genes are utilized to describe relations of genes in a disease attack process by relying on the network, genetic expression data of a specific patient is combined, a gene ranking algorithm capable of using a regulation and control relation among the genes is adopted to excavate key genes in the disease attack process of the specific patient to construct a key gene list, and thus personalized medication is conducted based on whether a drug target significantly targets the key genes in the disease attack process of the specific patient or not. The systematic pharmacology method of personalized medication is easy to achieve, low in cost, high in efficiency, and has a wide application prospect range in precision medicine and drug discovery.

A system and method for an adjustable bio-stream self-selecting system. Through a plethora of inputs, the system associates therapeutic recipes and associated biomarker in a personalized approach to recommending an individual to a specific therapeutic program. Therapeutic programs operate in accordance with personalized inputs suggested by the user and through digital markers and biomarkers, which trigger new recommendations by “knowing” the individual. Each bio-stream contains information utilized within these biomarkers to trigger additional therapy recommendations. Because of the complexity of the plurality of inputs, these biomarkers are managed in a way that enables low latency detections, low bandwidth needs, low processing needs, and less battery needs. The pre-processing of these biomarkers helps additional therapy management and precision medicine across larger global population needs of the system.

The present invention discloses a systematic pharmacological method for personalized medicine. In the present invention, biological networks such as gene dependence networks are employed to reflect relationships between genes in pathogenesis. In combination with the gene expression data of a specific patient, a gene rank algorithm, which is capable of utilizing inter-genetic regulation relationships to mine key genes in the pathogenesis of disease in a specific patient, is used to construct a key genes list. Then, personalized medicine is carried out according to whether the drug targets are significantly targeted to the key genes list in the pathogenesis of disease in the specific patient. The systematic pharmacological method for personalized medicine proposed by the present invention is easy to implement, has low cost and high efficiency, and has wide application prospects in precision medicine and drug discovery.

The invention belongs to the field of genetics and precision medicines and relates to a novel method of targeted specific segment ultrahigh multiple PCR and rapid library construction. According to the method provided by the invention, a high quality library which meets the downstream analysis requirements can be acquired by taking 2.5-50ng extracted DNA as a template within 2-3h, and sample differentiation barcode is automatically added at a primer end in the library building process without secondary library building; amplicons of offload data are high in uniformity, hotspots on 99.5 percentof the amplicons reach 1200X coverage in the premise of 1M Reads; and the specificity is high, and 100 percent of a target sequence can all be effectively amplified; and addition of a library joint is directional, so that the data utilization ratio can be increased, and the library quality can be improved.

The invention integrates emerging applications, tools and techniques for machine learning in medicine with videoconference networking technology in novel business methods that support rapid adaptive learning for medical minds and machines. These methods can leverage domain knowledge and clinical expertise with cognitive collaboration, augmented medical intelligence and cybernetic workflow streams for learning health care systems. The invention enables multimodal cognitive communications, collaboration, consultation and instruction between and among cognitive collaborants, including heterogeneous networked teams of persons, machines, devices, neural networks, robots and algorithms. It provides for both synchronous and asynchronous cognitive collaboration with multichannel, multiplexed imagery data streams during various stages of medical disease and injury management—detection, diagnosis, prognosis, treatment, measurement and monitoring, as well as resource utilization and outcomes reporting. The invention acquires both live stream and archived medical imagery data from network-connected medical devices, cameras, signals, sensors and imagery data repositories, as well as multiomic data sets from structured reports and clinical documents. It enables cognitive curation, annotation and tagging, as well as encapsulation, saving and sharing of collaborated imagery data streams as packetized medical intelligence. The invention augments packetized medical intelligence through recursive cognitive enrichment, including multimodal annotation and [semantic] metadata tagging with resources consumed and outcomes delivered. Augmented medical intelligence can be saved and stored in multiple formats, as well as retrieved from standards-based repositories. The invention provides neurosynaptic network connectivity for medical images and video with multi-channel, multiplexed gateway streamer servers that can be configured to support workflow orchestration across the enterprise—on platform, federated or cloud data architectures, including ecosystem partners. It also supports novel methods for managing augmented medical intelligence with networked metadata repositories [inclduing imagery data streams annotated with semantic metadata]. The invention helps prepare streaming imagery data for cognitive enterprise imaging. It can be incorporate and combine various machine learning techniques [e.g., deep, reinforcement and transfer learning, convolutional neural networks and NLP] to assist in curating, annotating and tagging diagnostic, procedural and evidentiary medical imaging. It also supports real-time, intraoperative imaging analytics for robotic-assisted surgery, as well as other imagery guided interventions. The invention facilitates collaborative precision medicine, and other clinical initiatives designed to reduce the cost of care, with precision diagnosis [e.g., integrated in vivo, in vitro, in silico] and precision targeted treatment [e.g., precision dosing, theranostics, computer-assited surgery]. Cybernetic workflow streams—cognitive communications, collaboration, consultation and instruction with augmented medical intelligence—enable care delivery teams of medical minds and machines to ‘deliver the right care, for the right patient, at the right time, in the right place’ - and deliver that care faster, smarter, safer, more precisely, cheaper and better.

The invention provides a facial spasm model based on MR images and a preparation method thereof, and the method comprises the steps: obtaining 3D high-resolution MRI scanning images of facial auditory nerves, adjacent blood vessels and brain stem through an MR nerve imaging sequence, importing the obtained original image data into modeling post-processing software, carrying out the image fusion, segmentation and reconstruction of the pressed facial auditory nerves, responsibility blood vessels and adjacent brain stem structures to obtain the three-dimensional anatomical model of facial spasm nerve vessel compression, and putting the three-dimensional anatomical model of facial spasm nerve vessel compression in a color 3D printer to print an individualized 3D printed solid model. The facial spasm nerve vessel compression form, degree, complex walking and front-back and up-down space relations of adjacent structures are effectively displayed, and the requirements of precise medical evaluation and operations are met. The model is used for preoperative planning, operation simulation and teaching training, reduces the exploration time in the micro-vascular decompression operation, reduces the operative complications, and improves the teaching effect of medical training.

The invention discloses a rapid and portable fluorescent quantitative PCR detection device and method. The device comprises a PCR reaction tube and a bifurcated optical fiber, wherein the bifurcated optical fiber comprises an optical fiber bundle end and an optical fiber branch end; the optical fiber bundle end comprises a central laser path, a light source excitation path and a fluorescence detection path; and a first light source excitation device, a second light source excitation device and a fluorescence detection device are arranged at the optical fiber branch end. The method comprises the following steps of adding a sample reaction solution into the PCR reaction tube, and sealing the PCR reaction tube with a sealing film; inserting the optical fiber bundle end into the PCR reaction tube through the sealing film; and irradiating a photo-thermal heating column by laser with different energy, irradiating a sample solution by the light source excitation path, and collecting fluorescence generated by the sample solution by an optical sensor. Rapid and portable detection of a trace sample is achieved, and good application prospects are achieved in the fields of molecular diagnosis, precision medicine, in-vitro detection and in-time diagnosis.