35 results about "Auditory nerves" patented technology

The invention relates to the technical field of medical data processing, in particular to a data analysis and processing system based on clinical hearing detection, and aims to solve the problems that dynamic characteristics of auditory nerve response cannot be systematically described, high-dimensional multi-modal feature vectors cannot be constructed, and the data analysis and processing efficiency is low in the prior art. A stable and reliable input basis cannot be provided for intelligent classification, anomaly detection and individualized analysis, and the sensitivity and specificity of hearing state recognition are reduced; the multi-dimensional hearing feature extraction module fuses time domain, frequency domain and non-linear complexity analysis methods, systematically depicts dynamic features of auditory nerve response, constructs a high-dimensional multi-modal feature vector by integrating three-dimensional features, remarkably improves sensitivity and specificity of hearing state recognition, and improves the accuracy of hearing state recognition. The feature representation method provides a stable and reliable input basis for subsequent intelligent classification, anomaly detection and individualized analysis.

1. Name of the product in this design: Behind-the-ear speech processor for cochlear implants. 2. Purpose of this design: to receive and process sound signals and convert them into electrical signals that can stimulate the auditory nerve, enabling hearing-impaired patients to regain hearing. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

Disclosed herein are of systems, methods, and computer-program products for determining if a response is an electrically evoked compound action potential (eCAP), refining raw data of an eCAP amplitude growth function (AGF) and utilizing maximum (i.e., steepest) slope from moving linear regression to effectively estimate cochlear nerve function, and determining quality of an electrode-neuron interface (ENI) using a model developed from eCAP attributes.

The invention discloses an HSP70-targeting chimeric antigen receptor-macrophage and application thereof in treatment of noise-induced hearing loss, an extracellular domain of the HSP70-targeting chimeric antigen receptor comprises an HSP70 specific binding fragment, an intracellular domain comprises an IL-4 signal channel functional element, a signal switch type CAR structure of the HSP70 is formed, and the macrophage can be used for treating noise-induced hearing loss, so that the HSP70-targeting chimeric antigen receptor-macrophage can be used for treating noise-induced hearing loss. The HSP70-targeted chimeric antigen receptor-macrophage can be used for preparing the HSP70-targeted chimeric antigen receptor-macrophage, is used for mediating polarization of the macrophage to an M2 type and exerting an anti-inflammatory function, is proved to be capable of specifically responding to an inner ear inflammation microenvironment, switching an anti-inflammatory phenotype and protecting hair cells and auditory nerves, can be used for treating noise-induced hearing loss, and can be used for preparing the HSP70-targeted chimeric antigen receptor-macrophage. The limitation that traditional hearing-aid equipment supports treatment on symptoms is broken through, and the hearing-aid device has a remarkable application prospect.

The invention provides an artificial cochlea system, method and device for intelligent language training and a storage medium, the system comprises an in-vitro sound processor, the in-vitro sound processor comprises an intelligent language training module, and the intelligent language training module is used for storing audio information; the in-vitro sound processor is used for converting the audio information in the intelligent language training module into a stimulation coding radio frequency electric signal; and the in-vivo implant is used for receiving the stimulation coding radio-frequency electric signal sent by the in-vitro sound processor and decoding the stimulation coding radio-frequency electric signal to generate a corresponding stimulation current which acts on the electrode array to stimulate auditory nerves, so that a user can generate auditory sense. The intelligent language training module is integrated in the external sound processor, the limitation that traditional equipment needs to be additionally connected with external playing equipment is broken through, language training can be carried out anytime and anywhere, fragmentation time is fully utilized, and the training frequency is increased; coordinated training is carried out based on the basic audio information and the personalized audio information, the boring feeling of language training can be remarkably reduced, and the matching degree and the training quality of the user are improved.

A cochlear hearing aid system for providing electrical stimulation to auditory nerve fibers of a cochlea of a recipient of the cochlear hearing aid system is disclosed. The cochlear hearing aid system comprises a microphone configured to receive an acoustical signal and provide an audio signal based on the acoustical signal; a signal processor unit configured to receive the audio signal and process the audio signal; an electrode lead including a plurality of electrodes configured to stimulate the auditory nerve fibers based on the processed audio signal, wherein the electrode lead comprises: an electrode carrier maintaining the electrode contacts and wires, wherein the electrode carrier is made of silicone and is loaded by dexamethasone; a first layer (or sub-layers) of gelatin which is coated and chemically cross-linked selectively on a silicone outer surface of the electrode lead, wherein dexamethasone sodium phosphate is embedded in the first layer (or sub-layers); and a second layer of gelatin which is coated and physically cross-linked onto the first layer.

This disclosure provides compositions and methods for treating sensorineural hearing loss and auditory neuropathy, particularly disease forms associated with otomorphin (OTOE) mutations, using OTOE gene therapy. The disclosure provides various compositions comprising a first nucleic acid vector containing a polynucleotide encoding the N-terminal portion of an OTOE isoform 5 protein and a second nucleic acid vector containing a polynucleotide encoding the C-terminal portion of an OTOE isoform 5 protein. These vectors can be used to increase OTOE expression in subjects, such as human subjects with sensorineural hearing loss.

The present invention aims to provide a method, apparatus, system, etc., for detecting indicators of acoustic neuroma by standardizing audiogram images or their constituent data and inputting them into an AI model. [Solution] An index detection method comprising: a storage step in which a computer stores images of audiogram-related information or their constituent data, which are information relating to an audiogram obtained about a target person, in a database; a standardization step in which data obtained from the audiogram images or the constituent data are standardized; an index detection step in which the standardized audiogram-related information is used as input to a trained model obtained by performing a learning process using data which is a combination of previously acquired and standardized audiogram-related information and an index of acoustic neuroma for that person, thereby detecting an index of acoustic neuroma for the target person; and a detection step in which the data is input to an AI model to detect an index of acoustic neuroma.

Presented herein are techniques that make use of objective measurements obtained in response to acoustic stimulation signals. More specifically, at least one measure of outer hair cell function and at least one measure of auditory nerve function are obtained from a tonotopic region of an inner ear of a recipient of a hearing prosthesis. The at least one measure of auditory nerve function and the least one measure of outer hair cell function are then analyzed relative to one another.

The invention provides a dual-channel closed-loop auditory function enhancement-expansion man-machine interaction system and method, the system comprises an intelligent auditory closed-loop controller, a cochlea implant and an invasive auditory corticobrain-computer interface module, the intelligent auditory closed-loop controller is used for receiving an acoustic signal and encoding the acoustic signal into a stimulation instruction; the intra-cochlea implant is implanted into the cochlea of the user and is used for stimulating auditory nerves of the cochlea based on the stimulation instruction; the intrusive auditory cortex brain-computer interface module is implanted into the auditory cortex of the user and is used for stimulating the auditory cortex of the user based on the stimulation instruction and collecting a neural signal of the auditory cortex in the stimulation process as a feedback signal; the feedback signal is transmitted to the intelligent auditory closed-loop controller, and the intelligent auditory closed-loop controller adjusts a stimulation instruction output by the intelligent auditory closed-loop controller based on the feedback signal, thereby realizing closed-loop control. According to the invention, a closed-loop auditory regulation and control mechanism is established, the adaptability to complex acoustic scenes is remarkably enhanced, and a more complete auditory solution can be provided for hearing impaired people.

The application discloses a chimeric antigen receptor-macrophage targeting HSP70 and application thereof in the treatment of noise-induced hearing loss, wherein the extracellular domain of the chimeric antigen receptor targeting HSP70 comprises an HSP70 specific binding fragment, and the intracellular domain comprises an IL-4 signal pathway functional element, forming a'signal switch type' CAR structure targeting HSP70, which can be used for preparing the chimeric antigen receptor-macrophage targeting HSP70 and mediating the polarization of the macrophage to M2 type and exerting the anti-inflammatory function. It has been verified that the chimeric antigen receptor-macrophage targeting HSP70 can specifically respond to the inner ear inflammatory microenvironment, switch the anti-inflammatory phenotype and protect the hair cells and auditory nerves, and can be used for treating the noise-induced hearing loss, breaking through the limitation of the symptomatic support treatment of the traditional hearing aid device and having a significant application prospect.

The utility model belongs to hearing equipment technical field especially relates to a bone conduction hearing aid earphone, including elastic band and the elastic shell that is connected to the bottom of elastic band, the inside fixed mounting of elastic shell has the circuit board, the upper surface fixed mounting of circuit board has permanent magnet and voice coil, one side fixed mounting of circuit board has control switch and outer magnetic ring, the other side fixed mounting of circuit board has inner magnetic sheet. This bone conduction hearing aid earphone, through adopting bone conduction mode transmission sound, converts electric signal into vibration signal, through with human skin and bone contact, with solid as medium directly conduction sound wave to auditory nerve, avoided traditional air conduction earphone through ear drum conduction sound, large volume caused the heavy load impact of ear drum, can effectively reduce the damage of long -term use to ear drum, reduce the risk of hearing further decline, especially suitable for hearing impaired population, especially severe deafness patient uses.

A composition comprising a liquid plasma according to the present invention can induce growth inhibition and death of brain tumor cells through the combined effect of radicals, ionic species, and pH effect, and thus can be effectively used for preventing or treating brain tumors. In addition, the present invention is a non-invasive physical and chemical treatment approach with low drug dependence, can exhibit a synergistic effect when used in combination with existing anticancer drugs, and has a high potential for application to the treatment of various nervous system tumors or metastatic brain diseases including glioblastoma and auditory nerve tumors.

The invention discloses an auditory neuron target extraction and positioning method based on a vertical model. Comprising the following steps: 1) preprocessing multi-modal data; 2) analyzing clinical symptom description in the current medical history by means of a Gemini vertical model; 3) constructing a multi-modal feature fusion module; and 4) dynamically analyzing auditory neurons of neuron images of different age groups. According to the method, screening and information identification are carried out on the neuron features of the specific area in the image, the difficulty that in the prior art, the positioning precision of auditory neurons in the image is low and the individual differences of patients cannot be dynamically adapted is overcome, and the analysis accuracy and efficiency are remarkably improved. Meanwhile, the dynamic adaptation capability of the technology can optimize an analysis strategy according to image signal characteristics of special crowds such as young people and old people, and fine analysis of an auditory nerve mechanism is promoted.

The invention relates to the technical field of bioengineering, in particular to a culture medium and a method for constructing auditory neuroma organs. According to the culture medium, Neurobase Medium and DMEM (Dulbecco Modified Eagle Medium) / F12 are used as a basic culture medium; the feed additive comprises a N2 additive, a B27 additive, L-alanyl-L-glutamine, an antibiotic, HEPES, glucose, beta-mercaptoethanol, a cell growth factor, MEM NEAA and a TGF-beta inhibitor. The cell growth factor is EGF (Epidermal Growth Factor) or FGF-2. The culture medium provided by the invention can effectively improve the construction efficiency of the auditory neuroma organoid, and the constructed auditory neuroma organoid can be used as a reliable in-vitro substitution model, is used for marker detection, drug screening and individualized medical exploration in basic research and clinical transformation research, and has important application value.

The present invention is in the field of hearing tests. In particular, the present invention relates to systems and methods for determining the integrity of Auditory Nerve Fibers (ANFs) and / or afferent Auditory Nerve Synapses (ANSs) and / or inner-hair cells (IHC) in a subject.

The invention discloses a cochlea nerve sound information transmission device and method based on double coaxial focused ultrasound nonlinear demodulation. The device comprises a double coaxial ultrasonic transducer, a focusing unit, a signal driving module and a control and safety module. The double coaxial ultrasonic transducer is provided with an inner transduction unit and an outer transduction unit which are used for transmitting ultrasonic waves with different carrier frequencies respectively; the focusing unit enables the two paths of ultrasonic waves to coincide in a cochlear nerve or related auditory nerve area space to form a focusing superposition sound field, a difference frequency component is generated after nonlinear action of human tissue, and localized transmission of audio information in a mode of generating only in a target area is achieved, and sound leakage in a non-target area is restrained. According to the method, complementary coding envelope, difference frequency verification closed loop and predistortion compensation are further introduced, the forming efficiency and consistency of effective audio envelope in a target region are improved, local mechanical vibration / pressure fluctuation caused by target region difference frequency directly acts on a mechanical sensitive ion channel of an auditory nerve related cell membrane, neuron excitation is promoted, and nerve response is opened.

A cochlear implant system using a compatible external device includes an external device that keeps mapping data, which are obtained by measuring a biological response to an electrical stimulation signal of an internal device implanted in a cochlear conduct of a user, for each internal device, determines whether there is compatibility with a target internal device, and converts sound into an electrical signal in accordance with mapping data of the target internal device of a plurality of pieces of mapping data, and a target internal device that receives an electrical signal from the external device, converts the electrical signal into an electrical stimulation signal, and stimulates the auditory nerve of a cochlea with the electrical stimulation signal when the external device is compatible.

The application relates to an apparatus for stimulating an auditory nerve with a (CMOS) chip; a plurality of optical elements for stimulating the auditory nerve; and at least one driver circuit for controlling the plurality of optical elements. The plurality of optical elements and the at least one driver circuit are integrated in the (CMOS) chip.

This application discloses a cochlear implantation system with improved time feature selection, comprising: a microphone unit; an electrode array; a processor unit including: a filter bank; a first time feature extractor configured to determine an initial set of time features of a bandpass audio signal; a second time feature extractor configured to window-filter the bandpass audio signal and determine a secondary set of time features of the window-filtered bandpass audio signal; a stimulation generator configured to determine a final set of time features based on the initial set of time features and the secondary set of time features, and to determine a similarity measure value between the initial set of time features and the secondary set of time features for the final set of time features; the processor unit configured to determine, based on the similarity measure value, whether the final set of time features will be encoded into a stimulation pulse; the encoded stimulation pulse is transmitted to an electrode configured to apply electrical stimulation to a group of auditory nerve fibers based on the encoded stimulation pulse.

The application discloses a device for rapid recovery of body perception after anesthesia, which is used for helping patients recover body perception faster after operation. The device is composed of a temperature rising wrapping blanket, a pneumatic touching assembly, a micro vibration motor array and a sound stimulation assembly. The temperature rising wrapping blanket wraps the patient's body, uses graphene heating wires to create a warm environment and promotes blood circulation. The pneumatic touching assembly pumps air to the silica gel airbag through a micro air pump, so that the silica gel airbag intermittently touches the patient's body, and a flexible pressure sensor monitors the touching pressure. The micro vibration motor array vibrates at different frequencies and intensities, gently awakens the sensory nerves. The sound stimulation assembly plays sound through a Bluetooth sound box, activates the auditory nerves. The components work together, and the device can adjust the stimulation intensity according to the patient's recovery condition, realize the stimulation of the mode and adapt the recovery process, help the patient shorten the stay time in the PACU, improve the turnover rate and improve the postoperative experience.

The application belongs to the technical field of biological medicine preparation, and particularly relates to an external use ear drop for promoting auditory nerve growth and a preparation method thereof. The composition raw materials comprise the following components: active small molecules, glyceryl stearate, glyceryl monostearate, soybean lecithin, vitamin E succinate, Tween-80, chitosan quaternary ammonium salt, diethylene glycol monoethyl ether, penetration aid, penetrant, sodium cholate, N-acetyl cysteine, F127 surfactant, F68 surfactant and sodium hyaluronate. Through the synergistic effect of the crystalline lipid core, the positive chitosan quaternary ammonium salt shell, the heat-sensitive in-situ gel outer layer and the mild penetration system, the drug is long-acting retained, smoothly released and efficiently penetrated into the inner ear target area under the condition of not puncturing the eardrum, and the synergistic system significantly improves the stability, local exposure and treatment efficiency of the drug.

The invention provides hearing aid equipment based on bone conduction, and belongs to the technical field of bone conduction equipment. Comprising a head band and bone conduction sound transmission devices installed at the two ends of the head band, and further comprises a noise reduction mechanism, and the noise reduction mechanism comprises connecting strips fixed to the tops of the bone conduction sound transmission devices. According to the bone conduction hearing aid, the earplug and the main elastic piece are arranged, the earplug is positioned on the side face of the main elastic piece, after the bone conduction hearing aid is worn, the earplug is plugged into the external auditory canal of a user, external noise is blocked through the earplug, and the external noise is effectively prevented from being transmitted to the auditory nerve of the inner ear of the user; according to the bone conduction hearing aid, sound of normal dialogue is stably transmitted to auditory nerves of inner ears of a user through the bone conduction hearing aid, so that the user can hear the dialogue clearly in a noisy environment, meanwhile, the earplugs are positioned under the elastic action of the main elastic pieces, the earplugs can be prevented from falling from external auditory canals of the user through the main elastic pieces, and the safety of the user is improved. And the wearing stability of the earplug is ensured.

This invention provides an optically-based fully implantable cochlear implant device, comprising: an optical sensing module for emitting a light source and receiving light signals reflected back from a sound vibration module; a photoelectric conversion module for converting the received light signals into alternating current (AC) signals; a sound processing module for processing sound information and converting the AC signals into direct current (DC) signals; a decoding stimulation module for decoding sound information and converting the DC signals into pulse signals; cochlear stimulation electrodes for performing auditory nerve electrical stimulation based on the pulse signals; and an implantable power supply module for supplying power. This invention utilizes non-contact optical sound sensing technology, which does not affect the stability of the tympanic membrane and ossicles, avoiding the risk that even slight displacement after long-term implantation can affect hearing. It improves the long-term reliability and stability of the acoustic sensors, thereby extending the overall lifespan of the fully implantable cochlear implant.

The utility model provides a fully-implantable artificial cochlea device based on optics, and the device comprises an optical sensing module which is used for emitting a light source and receiving an optical signal reflected by a sound vibration module; the photoelectric conversion module is used for converting the received optical signal into an alternating current signal; the sound processing module is used for processing sound information and converting the alternating current signal into a direct current signal; the decoding stimulation module is used for decoding the sound information and converting the direct current signal into a pulse signal; the cochlea stimulation electrode is used for performing auditory nerve electrical stimulation based on the pulse signal; and the implanted power supply module is used for supplying power. Through the non-contact optical sound sensing technology, the stability of the tympanic membrane and the auditory ossicle of the human body cannot be affected, the risk that the hearing effect is affected by tiny displacement after long-term implantation is avoided, the long-term reliability and stability of the acoustic sensor are improved, and therefore the service life of the whole full-implantation type artificial cochlea is prolonged.

The invention provides a closed-loop adaptive implantable brain-ear nerve interface system and method.The system comprises an in-vitro machine, an implant circuit, an implantable artificial cochlea electrode and an implantable brain electrode, and the in-vitro machine is used for receiving external sound, encoding the external sound into a stimulation instruction and outputting the stimulation instruction; the implant circuit is in communication connection with the extracorporeal machine and is used for receiving and decoding the stimulation instruction; the implantable artificial cochlea electrode is in circuit connection with the implant and is used for applying electrical stimulation to auditory nerves of a user according to the decoded stimulation instruction; the implantable brain electrode is connected with the implant circuit, and the implant circuit is used for receiving an electroencephalogram signal collected by the implantable brain electrode; the electroencephalogram signals are transmitted to the in-vitro machine, and the in-vitro machine adaptively adjusts a stimulation instruction output by the in-vitro machine based on the electroencephalogram signals, so that closed-loop control is realized. According to the brain-ear nerve interface system, the artificial cochlea can be optimized and adjusted automatically and continuously in real time, and the auditory effect which can be achieved by the artificial cochlea is remarkably improved.

A system for providing electrical stimulation to a recipient is disclosed. The system comprises a microphone configured to receive an acoustical signal and provide an audio signal based on the acoustical signal; a signal processor unit configured to receive the audio signal and process the audio signal; an electrode lead including a plurality of electrodes configured to stimulate the auditory nerve fibers based on the processed audio signal, wherein the electrode lead comprises: an electrode carrier maintaining the electrode contacts and wires, wherein the electrode carrier includes a first layer of gelatin and a second layer of gelatin which is coated and physically cross-linked onto the first layer.

This cochlear implant includes a neural stimulator that stimulates the auditory nerve connected to the cochlea. The neural stimulator includes: a first coil unit that receives power, data, or both from an external apparatus; a first magnet unit attached to the external apparatus by magnetic force and including two or more pairs of stimuli (magnetic poles) arranged so as to have magnetic fields that cancel out each other; a neural stimulation processing unit that processes neural stimulation signals; and a neural stimulation electrode that stimulates the auditory nerve on the basis of the neural stimulation signals.

In a hearing aid device (100) having at least one acoustic sensor (111) for converting ambient sounds and noises into electrical vibrations and at least one vibration component (121) that can be placed in or near the user's ear and converts the electrical vibrations into auditory nerve impulses, the device can detect directional information of different sound sources from the user's environment by providing a plurality of acoustic sensors (111, 112, 113, 114) that can be placed in different locations in or near the user's ear, thereby detecting the directional information of different sound sources in the user's environment. Directional information of multiple different sound sources distributed throughout the ear is maintained while avoiding airborne interference noise, and due to their individual placement, the acoustic sensors receive sound waves from each sound source at a time offset from one another and generate corresponding electrical vibrations that are time offset from one another, and each of the acoustic sensors (111, 112, 113) is uniquely assigned an auditory nerve stimulation device (121, 122, 123, 124) that is located within the cochlea (210) of the target ear (200) and responds to the electrical signals.