54 results about "Auditory nerves" patented technology

The invention relates to the technical field of medical data processing, in particular to a data analysis and processing system based on clinical hearing detection, and aims to solve the problems that dynamic characteristics of auditory nerve response cannot be systematically described, high-dimensional multi-modal feature vectors cannot be constructed, and the data analysis and processing efficiency is low in the prior art. A stable and reliable input basis cannot be provided for intelligent classification, anomaly detection and individualized analysis, and the sensitivity and specificity of hearing state recognition are reduced; the multi-dimensional hearing feature extraction module fuses time domain, frequency domain and non-linear complexity analysis methods, systematically depicts dynamic features of auditory nerve response, constructs a high-dimensional multi-modal feature vector by integrating three-dimensional features, remarkably improves sensitivity and specificity of hearing state recognition, and improves the accuracy of hearing state recognition. The feature representation method provides a stable and reliable input basis for subsequent intelligent classification, anomaly detection and individualized analysis.

1. Name of the product in this design: Behind-the-ear speech processor for cochlear implants. 2. Purpose of this design: to receive and process sound signals and convert them into electrical signals that can stimulate the auditory nerve, enabling hearing-impaired patients to regain hearing. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses a photostimulation artificial cochlea which comprises an in-vitro machine and an implant, the in-vitro machine is divided into a sound processor and a transmitting coil, the in-vivo implant is divided into a receiving coil, a decoder and a nano laser, and the sound processor is used for processing sound signals and generating corresponding current parameters; the transmitting coil is used for transmitting a radio-frequency signal carrying a current parameter to the in-vivo implant by utilizing electromagnetic induction; the receiving coil is used for receiving the radio frequency signal transmitted by the transmitting coil; the decoder is used for analyzing the radio-frequency signal, restoring the radio-frequency signal into an electric signal and sending the electric signal to the corresponding nano laser; the nanometer laser is used for converting a received electric signal into a laser signal, and the laser signal is irradiated to the auditory nerve element through the optical fiber or directly irradiated to realize optical stimulation. According to the invention, efficient and fidelity transmission and processing of sound are realized, auditory definition and spatial resolution of a user are improved, and more natural and comfortable auditory experience is provided for a patient with hearing impairment.

Disclosed herein are of systems, methods, and computer-program products for determining if a response is an electrically evoked compound action potential (eCAP), refining raw data of an eCAP amplitude growth function (AGF) and utilizing maximum (i.e., steepest) slope from moving linear regression to effectively estimate cochlear nerve function, and determining quality of an electrode-neuron interface (ENI) using a model developed from eCAP attributes.

The invention discloses an optical fully-implanted artificial cochlea, which comprises a laser transceiving unit, a sound signal processing unit, an electrode array unit, a dual-mode coil unit and a built-in battery, and is characterized in that the laser transceiving unit is implanted into a middle ear cavity, is used for transmitting and receiving laser signals and comprises a transmitting end and a receiving end, the transmitting end continuously transmits laser to a tympanic membrane, and the receiving end is used for receiving the laser signals; the tympanic membrane vibrates to modulate the optical signal; the receiving end carries out demodulation and signal extraction on the reflected light; the sound signal processing unit is implanted under the skin behind the ear and is used for extracting and coding the characteristics of sound signals; the electrode array unit is implanted into the cochlea, and sound signals are transmitted by electrically stimulating auditory nerve elements in the cochlea; the dual-mode coil unit is implanted under the skin behind the ear and is used for wireless transmission of external signals and wireless charging energy complementation. According to the invention, efficient and fidelity transmission and processing of sound are realized, so that the existing artificial cochlea technology is thoroughly innovated, and more natural and comfortable auditory experience is provided for hearing impairment patients.

The invention discloses an HSP70-targeting chimeric antigen receptor-macrophage and application thereof in treatment of noise-induced hearing loss, an extracellular domain of the HSP70-targeting chimeric antigen receptor comprises an HSP70 specific binding fragment, an intracellular domain comprises an IL-4 signal channel functional element, a signal switch type CAR structure of the HSP70 is formed, and the macrophage can be used for treating noise-induced hearing loss, so that the HSP70-targeting chimeric antigen receptor-macrophage can be used for treating noise-induced hearing loss. The HSP70-targeted chimeric antigen receptor-macrophage can be used for preparing the HSP70-targeted chimeric antigen receptor-macrophage, is used for mediating polarization of the macrophage to an M2 type and exerting an anti-inflammatory function, is proved to be capable of specifically responding to an inner ear inflammation microenvironment, switching an anti-inflammatory phenotype and protecting hair cells and auditory nerves, can be used for treating noise-induced hearing loss, and can be used for preparing the HSP70-targeted chimeric antigen receptor-macrophage. The limitation that traditional hearing-aid equipment supports treatment on symptoms is broken through, and the hearing-aid device has a remarkable application prospect.

The invention provides an artificial cochlea system, method and device for intelligent language training and a storage medium, the system comprises an in-vitro sound processor, the in-vitro sound processor comprises an intelligent language training module, and the intelligent language training module is used for storing audio information; the in-vitro sound processor is used for converting the audio information in the intelligent language training module into a stimulation coding radio frequency electric signal; and the in-vivo implant is used for receiving the stimulation coding radio-frequency electric signal sent by the in-vitro sound processor and decoding the stimulation coding radio-frequency electric signal to generate a corresponding stimulation current which acts on the electrode array to stimulate auditory nerves, so that a user can generate auditory sense. The intelligent language training module is integrated in the external sound processor, the limitation that traditional equipment needs to be additionally connected with external playing equipment is broken through, language training can be carried out anytime and anywhere, fragmentation time is fully utilized, and the training frequency is increased; coordinated training is carried out based on the basic audio information and the personalized audio information, the boring feeling of language training can be remarkably reduced, and the matching degree and the training quality of the user are improved.

1. The name of the design product: artificial cochlea (2). 2. The use of the design product: special sound-electric conversion device for converting sound signal into electric signal, stimulating auditory nerve, for hearing recovery of patients with severe or extremely severe sensorineural hearing loss. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

A cochlear hearing aid system for providing electrical stimulation to auditory nerve fibers of a cochlea of a recipient of the cochlear hearing aid system is disclosed. The cochlear hearing aid system comprises a microphone configured to receive an acoustical signal and provide an audio signal based on the acoustical signal; a signal processor unit configured to receive the audio signal and process the audio signal; an electrode lead including a plurality of electrodes configured to stimulate the auditory nerve fibers based on the processed audio signal, wherein the electrode lead comprises: an electrode carrier maintaining the electrode contacts and wires, wherein the electrode carrier is made of silicone and is loaded by dexamethasone; a first layer (or sub-layers) of gelatin which is coated and chemically cross-linked selectively on a silicone outer surface of the electrode lead, wherein dexamethasone sodium phosphate is embedded in the first layer (or sub-layers); and a second layer of gelatin which is coated and physically cross-linked onto the first layer.

This disclosure provides compositions and methods for treating sensorineural hearing loss and auditory neuropathy, particularly disease forms associated with otomorphin (OTOE) mutations, using OTOE gene therapy. The disclosure provides various compositions comprising a first nucleic acid vector containing a polynucleotide encoding the N-terminal portion of an OTOE isoform 5 protein and a second nucleic acid vector containing a polynucleotide encoding the C-terminal portion of an OTOE isoform 5 protein. These vectors can be used to increase OTOE expression in subjects, such as human subjects with sensorineural hearing loss.

The present invention aims to provide a method, apparatus, system, etc., for detecting indicators of acoustic neuroma by standardizing audiogram images or their constituent data and inputting them into an AI model. [Solution] An index detection method comprising: a storage step in which a computer stores images of audiogram-related information or their constituent data, which are information relating to an audiogram obtained about a target person, in a database; a standardization step in which data obtained from the audiogram images or the constituent data are standardized; an index detection step in which the standardized audiogram-related information is used as input to a trained model obtained by performing a learning process using data which is a combination of previously acquired and standardized audiogram-related information and an index of acoustic neuroma for that person, thereby detecting an index of acoustic neuroma for the target person; and a detection step in which the data is input to an AI model to detect an index of acoustic neuroma.

Presented herein are techniques that make use of objective measurements obtained in response to acoustic stimulation signals. More specifically, at least one measure of outer hair cell function and at least one measure of auditory nerve function are obtained from a tonotopic region of an inner ear of a recipient of a hearing prosthesis. The at least one measure of auditory nerve function and the least one measure of outer hair cell function are then analyzed relative to one another.

The invention provides a dual-channel closed-loop auditory function enhancement-expansion man-machine interaction system and method, the system comprises an intelligent auditory closed-loop controller, a cochlea implant and an invasive auditory corticobrain-computer interface module, the intelligent auditory closed-loop controller is used for receiving an acoustic signal and encoding the acoustic signal into a stimulation instruction; the intra-cochlea implant is implanted into the cochlea of the user and is used for stimulating auditory nerves of the cochlea based on the stimulation instruction; the intrusive auditory cortex brain-computer interface module is implanted into the auditory cortex of the user and is used for stimulating the auditory cortex of the user based on the stimulation instruction and collecting a neural signal of the auditory cortex in the stimulation process as a feedback signal; the feedback signal is transmitted to the intelligent auditory closed-loop controller, and the intelligent auditory closed-loop controller adjusts a stimulation instruction output by the intelligent auditory closed-loop controller based on the feedback signal, thereby realizing closed-loop control. According to the invention, a closed-loop auditory regulation and control mechanism is established, the adaptability to complex acoustic scenes is remarkably enhanced, and a more complete auditory solution can be provided for hearing impaired people.

In a hearing aid device (100) having at least one acoustic sensor (111) for converting ambient sound and noise into electrical vibrations and at least one vibrating element (121) which can be placed in or near a user's ear for converting electrical vibrations into auditory nerve pulses, aerial interfering noise is avoided by providing a plurality of acoustic sensors (111, 112, 113, 114) that can be placed on or in different locations within the user's ear for detecting orientation information of different sound sources from the user's environment to maintain orientation information of a plurality of different sound sources distributed in the user's surrounding space. The invention relates to an ear (200) comprising acoustic sensors (111, 112, 113), which receive the acoustic waves of the respective sound sources in a mutually time-shifted manner due to their individual placement and produce electrical oscillations that are respectively mutually time-shifted, with auditory nerve stimulation means (121, 122, 123, 124) within the cochlea (210) of the ear (200) in question and uniquely assigned to each acoustic sensor (111, 112, 113), which are responsive to the electrical signals.

The invention discloses a photoelectric artificial cochlea, which comprises an extracorporeal machine and an implant, and is characterized in that the extracorporeal machine is configured to receive an original sound signal, process the original sound signal into a first analog signal or a conversion signal of the first analog signal, and transmit the first analog signal or the conversion signal to the implant; the implant comprises a stimulator, the stimulator comprises a photoelectric hybrid chip, the photoelectric hybrid chip is configured to receive an input signal and modulate a carrier optical signal by using the input signal to output a modulated carrier optical signal, the modulated carrier optical signal is an analog signal, and the input signal is a first analog signal or a conversion signal of the first analog signal; the implant comprises an optical fiber electrode, and the optical fiber electrode is implanted from the round window of the human ear, is arranged in the drum step, extends from the cochlea bottom to the cochlea top and directly acts on the auditory neuron, so that the high-frequency component of the modulated carrier optical signal is preferentially demodulated at the cochlea bottom, and the low-frequency component of the modulated carrier optical signal is preferentially demodulated at the cochlea top. Therefore, the photoelectric artificial cochlea system which is low in power consumption, high in fidelity and accurate in directional stimulation is realized.

The application discloses an ear canal embedded acoustic genetic hearing aid, which comprises a hearing aid body, a sound control unit encapsulated in the hearing aid body and a plurality of ultrasonic emitters, all of which are connected with the sound control unit, and the sound control unit is used for collecting external sound and converting and processing the external sound into an electric stimulation signal to control the ultrasonic emitters to emit ultrasonic waves outward. The acoustic genetic hearing aid provided by the application can convert external sound information into ultrasonic waves through a method combining medicine and equipment and deliver the ultrasonic waves to auditory nerves, so that precise control of transmission signals and response nerve cells can be realized, hearing impairment can be repaired, the quality of sound heard by a patient is enhanced, and the stimulation precision and penetrability are obviously improved, and the acoustic genetic hearing aid does not need to be implanted through surgery.

The application discloses a chimeric antigen receptor-macrophage targeting HSP70 and application thereof in the treatment of noise-induced hearing loss, wherein the extracellular domain of the chimeric antigen receptor targeting HSP70 comprises an HSP70 specific binding fragment, and the intracellular domain comprises an IL-4 signal pathway functional element, forming a'signal switch type' CAR structure targeting HSP70, which can be used for preparing the chimeric antigen receptor-macrophage targeting HSP70 and mediating the polarization of the macrophage to M2 type and exerting the anti-inflammatory function. It has been verified that the chimeric antigen receptor-macrophage targeting HSP70 can specifically respond to the inner ear inflammatory microenvironment, switch the anti-inflammatory phenotype and protect the hair cells and auditory nerves, and can be used for treating the noise-induced hearing loss, breaking through the limitation of the symptomatic support treatment of the traditional hearing aid device and having a significant application prospect.

The utility model belongs to hearing equipment technical field especially relates to a bone conduction hearing aid earphone, including elastic band and the elastic shell that is connected to the bottom of elastic band, the inside fixed mounting of elastic shell has the circuit board, the upper surface fixed mounting of circuit board has permanent magnet and voice coil, one side fixed mounting of circuit board has control switch and outer magnetic ring, the other side fixed mounting of circuit board has inner magnetic sheet. This bone conduction hearing aid earphone, through adopting bone conduction mode transmission sound, converts electric signal into vibration signal, through with human skin and bone contact, with solid as medium directly conduction sound wave to auditory nerve, avoided traditional air conduction earphone through ear drum conduction sound, large volume caused the heavy load impact of ear drum, can effectively reduce the damage of long -term use to ear drum, reduce the risk of hearing further decline, especially suitable for hearing impaired population, especially severe deafness patient uses.

The application provides a speech interaction recognition enhancement method, which comprises the following steps: collecting a video of a speaker facing a camera for speech interaction, splitting the video into N segments of to-be-identified speech and N frames of to-be-identified images, and forming to-be-identified data; inputting the to-be-identified data into a preset speech interaction recognition enhancement model, wherein the model comprises a lip feature extraction network, a speech feature extraction network, a time feature extraction network and an activation network, the time feature extraction network is used for adding time sequence information to a lip feature matrix extracted by the lip feature extraction network and a speech feature matrix extracted by the speech feature extraction network, the activation network is used for simulating an activation-inhibition mechanism of visual information on an auditory nerve circuit in a biological brain, realizing the interaction of two modalities of vision and hearing, and obtaining a speech recognition result. The application realizes the accurate recognition of lip language and speech in a noisy environment by using the dual-modality speech recognition of vision and hearing, and the response capability and accuracy meet the requirements.

Presented herein are techniques that make use of objective measurements obtained in response to acoustic stimulation signals. More specifically, at least one measure of outer hair cell function and at least one measure of auditory nerve function are obtained from a tonotopic region of an inner ear of a recipient of a hearing prosthesis. The at least one measure of auditory nerve function and the least one measure of outer hair cell function are then analyzed relative to one another.

A composition comprising a liquid plasma according to the present invention can induce growth inhibition and death of brain tumor cells through the combined effect of radicals, ionic species, and pH effect, and thus can be effectively used for preventing or treating brain tumors. In addition, the present invention is a non-invasive physical and chemical treatment approach with low drug dependence, can exhibit a synergistic effect when used in combination with existing anticancer drugs, and has a high potential for application to the treatment of various nervous system tumors or metastatic brain diseases including glioblastoma and auditory nerve tumors.

The present application belongs to the field of signal processing technology. The present application provides an auditory nerve feature extraction method for ship radiation noise identification. The disclosed embodiment collects EEG data induced by ship radiation noise stimulation, pre-processes the EEG signals induced by different ship radiation noise stimulations to obtain EEG segmented data; performs EEG feature statistical analysis on the EEG segmented data to obtain an EEG data set; performs feature extraction and dimensionality reduction operations on the EEG data set to obtain EEG features; trains and tests the SVM model using the EEG features to obtain a trained SVM model; inputs the test data set into the trained SVM model to obtain auditory nerve features. According to the discrimination strategies adopted by different types of ships, a basis is provided for designing a more effective recognition mechanism, especially when classifying ships, a personalized recognition method can be adopted, thereby improving the adaptability and accuracy of the system.

The invention discloses an auditory neuron target extraction and positioning method based on a vertical model. Comprising the following steps: 1) preprocessing multi-modal data; 2) analyzing clinical symptom description in the current medical history by means of a Gemini vertical model; 3) constructing a multi-modal feature fusion module; and 4) dynamically analyzing auditory neurons of neuron images of different age groups. According to the method, screening and information identification are carried out on the neuron features of the specific area in the image, the difficulty that in the prior art, the positioning precision of auditory neurons in the image is low and the individual differences of patients cannot be dynamically adapted is overcome, and the analysis accuracy and efficiency are remarkably improved. Meanwhile, the dynamic adaptation capability of the technology can optimize an analysis strategy according to image signal characteristics of special crowds such as young people and old people, and fine analysis of an auditory nerve mechanism is promoted.

The invention relates to the technical field of bioengineering, in particular to a culture medium and a method for constructing auditory neuroma organs. According to the culture medium, Neurobase Medium and DMEM (Dulbecco Modified Eagle Medium) / F12 are used as a basic culture medium; the feed additive comprises a N2 additive, a B27 additive, L-alanyl-L-glutamine, an antibiotic, HEPES, glucose, beta-mercaptoethanol, a cell growth factor, MEM NEAA and a TGF-beta inhibitor. The cell growth factor is EGF (Epidermal Growth Factor) or FGF-2. The culture medium provided by the invention can effectively improve the construction efficiency of the auditory neuroma organoid, and the constructed auditory neuroma organoid can be used as a reliable in-vitro substitution model, is used for marker detection, drug screening and individualized medical exploration in basic research and clinical transformation research, and has important application value.

The present invention is in the field of hearing tests. In particular, the present invention relates to systems and methods for determining the integrity of Auditory Nerve Fibers (ANFs) and / or afferent Auditory Nerve Synapses (ANSs) and / or inner-hair cells (IHC) in a subject.

The invention provides a multi-modal screening system and method for candidate patients for cochlear implantation of senile deaf patients. The method comprises the steps that the relative telomere length of leukocyte DNA in peripheral blood sample data of the senile deaf patients and a temporal bone three-dimensional image of the senile deaf patients are obtained; analyzing the temporal bone three-dimensional image to obtain an oval window width and an included angle between a facial nerve level segment and a projia; obtaining an electric evoked compound action potential signal of the auditory nerve of the senile deafness patient under the electric stimulation effect of the preset parameters, and obtaining a filtered electric evoked compound action potential signal; based on the telomere relative length, the oval window width, the included angle and the filtered electric evoked composite action potential signal, candidate patients suitable for cochlear implant implantation are judged; according to the technical scheme provided by the invention, the construction of a comprehensive evaluation system is realized, so that the artificial cochlea implantation fitness of the patient is evaluated more accurately, and the scientificity and reliability of candidate patient screening are improved.

The invention discloses a cochlea nerve sound information transmission device and method based on double coaxial focused ultrasound nonlinear demodulation. The device comprises a double coaxial ultrasonic transducer, a focusing unit, a signal driving module and a control and safety module. The double coaxial ultrasonic transducer is provided with an inner transduction unit and an outer transduction unit which are used for transmitting ultrasonic waves with different carrier frequencies respectively; the focusing unit enables the two paths of ultrasonic waves to coincide in a cochlear nerve or related auditory nerve area space to form a focusing superposition sound field, a difference frequency component is generated after nonlinear action of human tissue, and localized transmission of audio information in a mode of generating only in a target area is achieved, and sound leakage in a non-target area is restrained. According to the method, complementary coding envelope, difference frequency verification closed loop and predistortion compensation are further introduced, the forming efficiency and consistency of effective audio envelope in a target region are improved, local mechanical vibration / pressure fluctuation caused by target region difference frequency directly acts on a mechanical sensitive ion channel of an auditory nerve related cell membrane, neuron excitation is promoted, and nerve response is opened.

The application discloses a kind of based on magnetoencephalogram and functional magnetic resonance imaging auditory nerve representation device, device includes: auditory stimulation system is used to generate magnetoencephalogram signal and functional magnetic resonance signal;Head-mounted array sensor system is used to collect generated magnetoencephalogram signal;Magnetoencephalogram signal acquisition system is used to receive the magnetoencephalogram signal;Functional magnetic resonance imaging signal acquisition system is used to receive the functional magnetic resonance signal;Magnetoencephalogram data preprocessing system is used to preprocess magnetoencephalogram signal, obtain magnetoencephalogram processing data;Functional magnetic resonance imaging data preprocessing system is used to preprocess the functional magnetic resonance signal, obtain function processing data;Dual-mode data joint analysis system is used to receive and fuse magnetoencephalogram processing data and function processing data, using support vector machine classifier constructs stimulation two two mutual classification diagonal symmetric representation dissimilarity matrix, according to representation dissimilarity matrix obtains auditory nerve representation result.

The invention discloses an artificial cochlea stimulation method, an artificial cochlea stimulation device and hearing aid equipment. The artificial cochlea stimulation method comprises the steps that a sound signal of an environment is collected, the sound signal is converted into a first digital signal, and the first digital signal comprises multiple frames of audio signals; determining a signal-to-noise ratio of the audio signal based on the first digital signal and a preset noise estimation algorithm; determining a plurality of formants based on the first digital signal and a preset formant neural network estimation model; based on the signal-to-noise ratio of the audio signal, the formants and a gain factor, frequency band energy corresponding to the formants is determined, and the gain factor is determined based on the signal-to-noise ratio; the frequency band energy is converted into electrode stimulation energy, and auditory nerves of the patient are stimulated based on the electrode stimulation energy. The method and the device have the technical effects of high voice distinguishing capability and high intelligibility in a noisy environment.