62 results about "Auditory nerves" patented technology

The invention provides an artificial cochlea which comprises an implant and an extracorporeal machine, the implant and the extracorporeal machine both adopt a magnet-free design, the extracorporeal machine is configured to receive a sound signal and transmit the sound signal to the implant after first processing, the implant is configured to perform second processing on the sound signal after first processing, and the implant is configured to perform second processing on the sound signal after second processing. The auditory neuron is stimulated by implanting an electrode; the in-vitro machine comprises an electrode array, the electrode array comprises a base and a plurality of electrode assemblies, and the electrode assemblies are inserted into a target scalp area in a semi-intrusive mode so that at least part of the in-vitro machine can be fixed to the target scalp area; wherein the implant is arranged on the inner side of the target scalp area, and the extracorporeal machine is arranged on the outer side of the target scalp area. And due to the non-magnet design, the artificial cochlea can improve the use experience of the user.

The invention relates to the technical field of medical data processing, in particular to a data analysis and processing system based on clinical hearing detection, and aims to solve the problems that dynamic characteristics of auditory nerve response cannot be systematically described, high-dimensional multi-modal feature vectors cannot be constructed, and the data analysis and processing efficiency is low in the prior art. A stable and reliable input basis cannot be provided for intelligent classification, anomaly detection and individualized analysis, and the sensitivity and specificity of hearing state recognition are reduced; the multi-dimensional hearing feature extraction module fuses time domain, frequency domain and non-linear complexity analysis methods, systematically depicts dynamic features of auditory nerve response, constructs a high-dimensional multi-modal feature vector by integrating three-dimensional features, remarkably improves sensitivity and specificity of hearing state recognition, and improves the accuracy of hearing state recognition. The feature representation method provides a stable and reliable input basis for subsequent intelligent classification, anomaly detection and individualized analysis.

1. Name of the product in this design: Behind-the-ear speech processor for cochlear implants. 2. Purpose of this design: to receive and process sound signals and convert them into electrical signals that can stimulate the auditory nerve, enabling hearing-impaired patients to regain hearing. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present invention discloses a cochlear implant system based on neural feedback closed-loop control, comprising an external part and an implant part. The external part comprises a mobile power supply, an external signal processing unit and a transmission coil, and the implant part comprises a receiving coil, an implant processing unit and a stimulation sampling electrode. The external signal processing unit comprises an acoustic-electric and feedback control module, a power module, a hardware acceleration module, a sensor module, a radio frequency modulation module and a storage module. The acoustic-electric and feedback processing module comprises a sound processing module, an acoustic-electric mapping module, a stimulus input encoding module and a feedback output decoding module. The implant processing unit comprises a radio frequency demodulation module, an auditory nerve signal processing module and an interface module. The interface module comprises a stimulation trigger module and a neural telemetry module. The present invention simulates the control mechanism of the auditory system, controls the stimulus input part through the neural feedback output part, and forms a complete closed-loop control to protect and enhance the hearing experience in a noisy environment.

The invention discloses a photostimulation artificial cochlea which comprises an in-vitro machine and an implant, the in-vitro machine is divided into a sound processor and a transmitting coil, the in-vivo implant is divided into a receiving coil, a decoder and a nano laser, and the sound processor is used for processing sound signals and generating corresponding current parameters; the transmitting coil is used for transmitting a radio-frequency signal carrying a current parameter to the in-vivo implant by utilizing electromagnetic induction; the receiving coil is used for receiving the radio frequency signal transmitted by the transmitting coil; the decoder is used for analyzing the radio-frequency signal, restoring the radio-frequency signal into an electric signal and sending the electric signal to the corresponding nano laser; the nanometer laser is used for converting a received electric signal into a laser signal, and the laser signal is irradiated to the auditory nerve element through the optical fiber or directly irradiated to realize optical stimulation. According to the invention, efficient and fidelity transmission and processing of sound are realized, auditory definition and spatial resolution of a user are improved, and more natural and comfortable auditory experience is provided for a patient with hearing impairment.

Disclosed herein are of systems, methods, and computer-program products for determining if a response is an electrically evoked compound action potential (eCAP), refining raw data of an eCAP amplitude growth function (AGF) and utilizing maximum (i.e., steepest) slope from moving linear regression to effectively estimate cochlear nerve function, and determining quality of an electrode-neuron interface (ENI) using a model developed from eCAP attributes.

An in-canal wireless transmitting system (ICWTS) is provided that is configured to be placed within an ear canal of a user and the ear. The ICWTS is associated with an implanted unit that is configured to stimulate an organ in the head of a user, such as an auditory nerve, vestibular system, brain, or a combination thereof. The ICWTS comprises a transmitting antenna configured to transmit electrical energy and receiver antenna configured to receive the electrical energy, wherein the electrical energy comprises data in the form of electrical signals as well as power, that function as power source configured to power the implanted unit through the transmitting antenna.

The invention discloses an optical fully-implanted artificial cochlea, which comprises a laser transceiving unit, a sound signal processing unit, an electrode array unit, a dual-mode coil unit and a built-in battery, and is characterized in that the laser transceiving unit is implanted into a middle ear cavity, is used for transmitting and receiving laser signals and comprises a transmitting end and a receiving end, the transmitting end continuously transmits laser to a tympanic membrane, and the receiving end is used for receiving the laser signals; the tympanic membrane vibrates to modulate the optical signal; the receiving end carries out demodulation and signal extraction on the reflected light; the sound signal processing unit is implanted under the skin behind the ear and is used for extracting and coding the characteristics of sound signals; the electrode array unit is implanted into the cochlea, and sound signals are transmitted by electrically stimulating auditory nerve elements in the cochlea; the dual-mode coil unit is implanted under the skin behind the ear and is used for wireless transmission of external signals and wireless charging energy complementation. According to the invention, efficient and fidelity transmission and processing of sound are realized, so that the existing artificial cochlea technology is thoroughly innovated, and more natural and comfortable auditory experience is provided for hearing impairment patients.

The invention discloses an HSP70-targeting chimeric antigen receptor-macrophage and application thereof in treatment of noise-induced hearing loss, an extracellular domain of the HSP70-targeting chimeric antigen receptor comprises an HSP70 specific binding fragment, an intracellular domain comprises an IL-4 signal channel functional element, a signal switch type CAR structure of the HSP70 is formed, and the macrophage can be used for treating noise-induced hearing loss, so that the HSP70-targeting chimeric antigen receptor-macrophage can be used for treating noise-induced hearing loss. The HSP70-targeted chimeric antigen receptor-macrophage can be used for preparing the HSP70-targeted chimeric antigen receptor-macrophage, is used for mediating polarization of the macrophage to an M2 type and exerting an anti-inflammatory function, is proved to be capable of specifically responding to an inner ear inflammation microenvironment, switching an anti-inflammatory phenotype and protecting hair cells and auditory nerves, can be used for treating noise-induced hearing loss, and can be used for preparing the HSP70-targeted chimeric antigen receptor-macrophage. The limitation that traditional hearing-aid equipment supports treatment on symptoms is broken through, and the hearing-aid device has a remarkable application prospect.

The invention provides an artificial cochlea system, method and device for intelligent language training and a storage medium, the system comprises an in-vitro sound processor, the in-vitro sound processor comprises an intelligent language training module, and the intelligent language training module is used for storing audio information; the in-vitro sound processor is used for converting the audio information in the intelligent language training module into a stimulation coding radio frequency electric signal; and the in-vivo implant is used for receiving the stimulation coding radio-frequency electric signal sent by the in-vitro sound processor and decoding the stimulation coding radio-frequency electric signal to generate a corresponding stimulation current which acts on the electrode array to stimulate auditory nerves, so that a user can generate auditory sense. The intelligent language training module is integrated in the external sound processor, the limitation that traditional equipment needs to be additionally connected with external playing equipment is broken through, language training can be carried out anytime and anywhere, fragmentation time is fully utilized, and the training frequency is increased; coordinated training is carried out based on the basic audio information and the personalized audio information, the boring feeling of language training can be remarkably reduced, and the matching degree and the training quality of the user are improved.

Disclosed is a method of selecting stimulations for a cochlear implant or an auditory implant. The method may include: capturing an acoustical signal; dividing the acoustical signal into a plurality of frequency bands; determining a mean acoustical energy for each frequency band; for each frequency band: comparing the mean acoustical energy with the mean acoustical energy determined for neighboring frequency bands; merging neighboring frequency bands having a difference between the mean acoustical energies that is less than an acoustical energy threshold value; selecting one or more types of stimulation to be applied to one or more locations in a cochlea or along an auditory nerve based on bandwidths of each frequency band. The one or more types of stimulation may be selected from: electrical stimulation, optical stimulation and opto-electrical stimulation, and the one or more locations in cochlea or along the auditory nerve may correspond to specific frequencies of the acoustical signal.

1. The name of the design product: artificial cochlea (2). 2. The use of the design product: special sound-electric conversion device for converting sound signal into electric signal, stimulating auditory nerve, for hearing recovery of patients with severe or extremely severe sensorineural hearing loss. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

A cochlear hearing aid system for providing electrical stimulation to auditory nerve fibers of a cochlea of a recipient of the cochlear hearing aid system is disclosed. The cochlear hearing aid system comprises a microphone configured to receive an acoustical signal and provide an audio signal based on the acoustical signal; a signal processor unit configured to receive the audio signal and process the audio signal; an electrode lead including a plurality of electrodes configured to stimulate the auditory nerve fibers based on the processed audio signal, wherein the electrode lead comprises: an electrode carrier maintaining the electrode contacts and wires, wherein the electrode carrier is made of silicone and is loaded by dexamethasone; a first layer (or sub-layers) of gelatin which is coated and chemically cross-linked selectively on a silicone outer surface of the electrode lead, wherein dexamethasone sodium phosphate is embedded in the first layer (or sub-layers); and a second layer of gelatin which is coated and physically cross-linked onto the first layer.

This disclosure provides compositions and methods for treating sensorineural hearing loss and auditory neuropathy, particularly disease forms associated with otomorphin (OTOE) mutations, using OTOE gene therapy. The disclosure provides various compositions comprising a first nucleic acid vector containing a polynucleotide encoding the N-terminal portion of an OTOE isoform 5 protein and a second nucleic acid vector containing a polynucleotide encoding the C-terminal portion of an OTOE isoform 5 protein. These vectors can be used to increase OTOE expression in subjects, such as human subjects with sensorineural hearing loss.

The present invention aims to provide a method, apparatus, system, etc., for detecting indicators of acoustic neuroma by standardizing audiogram images or their constituent data and inputting them into an AI model. [Solution] An index detection method comprising: a storage step in which a computer stores images of audiogram-related information or their constituent data, which are information relating to an audiogram obtained about a target person, in a database; a standardization step in which data obtained from the audiogram images or the constituent data are standardized; an index detection step in which the standardized audiogram-related information is used as input to a trained model obtained by performing a learning process using data which is a combination of previously acquired and standardized audiogram-related information and an index of acoustic neuroma for that person, thereby detecting an index of acoustic neuroma for the target person; and a detection step in which the data is input to an AI model to detect an index of acoustic neuroma.

Presented herein are techniques that make use of objective measurements obtained in response to acoustic stimulation signals. More specifically, at least one measure of outer hair cell function and at least one measure of auditory nerve function are obtained from a tonotopic region of an inner ear of a recipient of a hearing prosthesis. The at least one measure of auditory nerve function and the least one measure of outer hair cell function are then analyzed relative to one another.

The present invention relies on the need for characterizing the response of the auditory, notably for diagnostic purpose and adjusting of the hearing apparatuses. For this, the inventors have found a new marker, which is the peak-to-plateau ratio of the peri-stimulus time response. The access to this value is easier to obtain than previously known markers. In particular, such value may be obtained in a non-invasive way opening the path to a non-invasive marker of ear disorder. The inventors already have obtained experimental proofs of the relevance of the peak-to-plateau ratio of the peri-stimulus time response in gerbil and in human beings.

The invention relates to a dietary therapy formula for repairing ear hearing nerve cells and a preparation method thereof. Components with homology of medicine and food are optimally selected, the salvia miltiorrhiza and the radix puerariae can increase blood flow of inner ears, promote nutrition delivery, inhibit vasospasm of the inner ears and reduce ischemic injury of hair cells, alpha-linolenic acid is provided for a human body by utilizing the flaxseeds and the walnuts and converted into DHA, the DHA directly participates in nerve myelin sheath reconstruction, auditory nerve signal conduction is enhanced, and the health care effect is achieved. Chinese yam and astragalus membranaceus can provide Chinese yam polysaccharide and astragaloside, the mitochondrial function is improved, and cell apoptosis is delayed. The whole component is low in sugar content, is suitable for diabetics, expands the application crowd and non-medicine products, can reduce the psychological burden of eaters taking medicines for a long time, and is beneficial to popularization and application.

The invention provides a dual-channel closed-loop auditory function enhancement-expansion man-machine interaction system and method, the system comprises an intelligent auditory closed-loop controller, a cochlea implant and an invasive auditory corticobrain-computer interface module, the intelligent auditory closed-loop controller is used for receiving an acoustic signal and encoding the acoustic signal into a stimulation instruction; the intra-cochlea implant is implanted into the cochlea of the user and is used for stimulating auditory nerves of the cochlea based on the stimulation instruction; the intrusive auditory cortex brain-computer interface module is implanted into the auditory cortex of the user and is used for stimulating the auditory cortex of the user based on the stimulation instruction and collecting a neural signal of the auditory cortex in the stimulation process as a feedback signal; the feedback signal is transmitted to the intelligent auditory closed-loop controller, and the intelligent auditory closed-loop controller adjusts a stimulation instruction output by the intelligent auditory closed-loop controller based on the feedback signal, thereby realizing closed-loop control. According to the invention, a closed-loop auditory regulation and control mechanism is established, the adaptability to complex acoustic scenes is remarkably enhanced, and a more complete auditory solution can be provided for hearing impaired people.

In a hearing aid device (100) having at least one acoustic sensor (111) for converting ambient sound and noise into electrical vibrations and at least one vibrating element (121) which can be placed in or near a user's ear for converting electrical vibrations into auditory nerve pulses, aerial interfering noise is avoided by providing a plurality of acoustic sensors (111, 112, 113, 114) that can be placed on or in different locations within the user's ear for detecting orientation information of different sound sources from the user's environment to maintain orientation information of a plurality of different sound sources distributed in the user's surrounding space. The invention relates to an ear (200) comprising acoustic sensors (111, 112, 113), which receive the acoustic waves of the respective sound sources in a mutually time-shifted manner due to their individual placement and produce electrical oscillations that are respectively mutually time-shifted, with auditory nerve stimulation means (121, 122, 123, 124) within the cochlea (210) of the ear (200) in question and uniquely assigned to each acoustic sensor (111, 112, 113), which are responsive to the electrical signals.

The invention discloses a photoelectric artificial cochlea, which comprises an extracorporeal machine and an implant, and is characterized in that the extracorporeal machine is configured to receive an original sound signal, process the original sound signal into a first analog signal or a conversion signal of the first analog signal, and transmit the first analog signal or the conversion signal to the implant; the implant comprises a stimulator, the stimulator comprises a photoelectric hybrid chip, the photoelectric hybrid chip is configured to receive an input signal and modulate a carrier optical signal by using the input signal to output a modulated carrier optical signal, the modulated carrier optical signal is an analog signal, and the input signal is a first analog signal or a conversion signal of the first analog signal; the implant comprises an optical fiber electrode, and the optical fiber electrode is implanted from the round window of the human ear, is arranged in the drum step, extends from the cochlea bottom to the cochlea top and directly acts on the auditory neuron, so that the high-frequency component of the modulated carrier optical signal is preferentially demodulated at the cochlea bottom, and the low-frequency component of the modulated carrier optical signal is preferentially demodulated at the cochlea top. Therefore, the photoelectric artificial cochlea system which is low in power consumption, high in fidelity and accurate in directional stimulation is realized.

The application discloses an ear canal embedded acoustic genetic hearing aid, which comprises a hearing aid body, a sound control unit encapsulated in the hearing aid body and a plurality of ultrasonic emitters, all of which are connected with the sound control unit, and the sound control unit is used for collecting external sound and converting and processing the external sound into an electric stimulation signal to control the ultrasonic emitters to emit ultrasonic waves outward. The acoustic genetic hearing aid provided by the application can convert external sound information into ultrasonic waves through a method combining medicine and equipment and deliver the ultrasonic waves to auditory nerves, so that precise control of transmission signals and response nerve cells can be realized, hearing impairment can be repaired, the quality of sound heard by a patient is enhanced, and the stimulation precision and penetrability are obviously improved, and the acoustic genetic hearing aid does not need to be implanted through surgery.

The application discloses a chimeric antigen receptor-macrophage targeting HSP70 and application thereof in the treatment of noise-induced hearing loss, wherein the extracellular domain of the chimeric antigen receptor targeting HSP70 comprises an HSP70 specific binding fragment, and the intracellular domain comprises an IL-4 signal pathway functional element, forming a'signal switch type' CAR structure targeting HSP70, which can be used for preparing the chimeric antigen receptor-macrophage targeting HSP70 and mediating the polarization of the macrophage to M2 type and exerting the anti-inflammatory function. It has been verified that the chimeric antigen receptor-macrophage targeting HSP70 can specifically respond to the inner ear inflammatory microenvironment, switch the anti-inflammatory phenotype and protect the hair cells and auditory nerves, and can be used for treating the noise-induced hearing loss, breaking through the limitation of the symptomatic support treatment of the traditional hearing aid device and having a significant application prospect.

The utility model belongs to hearing equipment technical field especially relates to a bone conduction hearing aid earphone, including elastic band and the elastic shell that is connected to the bottom of elastic band, the inside fixed mounting of elastic shell has the circuit board, the upper surface fixed mounting of circuit board has permanent magnet and voice coil, one side fixed mounting of circuit board has control switch and outer magnetic ring, the other side fixed mounting of circuit board has inner magnetic sheet. This bone conduction hearing aid earphone, through adopting bone conduction mode transmission sound, converts electric signal into vibration signal, through with human skin and bone contact, with solid as medium directly conduction sound wave to auditory nerve, avoided traditional air conduction earphone through ear drum conduction sound, large volume caused the heavy load impact of ear drum, can effectively reduce the damage of long -term use to ear drum, reduce the risk of hearing further decline, especially suitable for hearing impaired population, especially severe deafness patient uses.

The application provides a speech interaction recognition enhancement method, which comprises the following steps: collecting a video of a speaker facing a camera for speech interaction, splitting the video into N segments of to-be-identified speech and N frames of to-be-identified images, and forming to-be-identified data; inputting the to-be-identified data into a preset speech interaction recognition enhancement model, wherein the model comprises a lip feature extraction network, a speech feature extraction network, a time feature extraction network and an activation network, the time feature extraction network is used for adding time sequence information to a lip feature matrix extracted by the lip feature extraction network and a speech feature matrix extracted by the speech feature extraction network, the activation network is used for simulating an activation-inhibition mechanism of visual information on an auditory nerve circuit in a biological brain, realizing the interaction of two modalities of vision and hearing, and obtaining a speech recognition result. The application realizes the accurate recognition of lip language and speech in a noisy environment by using the dual-modality speech recognition of vision and hearing, and the response capability and accuracy meet the requirements.

Presented herein are techniques that make use of objective measurements obtained in response to acoustic stimulation signals. More specifically, at least one measure of outer hair cell function and at least one measure of auditory nerve function are obtained from a tonotopic region of an inner ear of a recipient of a hearing prosthesis. The at least one measure of auditory nerve function and the least one measure of outer hair cell function are then analyzed relative to one another.

A composition comprising a liquid plasma according to the present invention can induce growth inhibition and death of brain tumor cells through the combined effect of radicals, ionic species, and pH effect, and thus can be effectively used for preventing or treating brain tumors. In addition, the present invention is a non-invasive physical and chemical treatment approach with low drug dependence, can exhibit a synergistic effect when used in combination with existing anticancer drugs, and has a high potential for application to the treatment of various nervous system tumors or metastatic brain diseases including glioblastoma and auditory nerve tumors.

The present application belongs to the field of signal processing technology. The present application provides an auditory nerve feature extraction method for ship radiation noise identification. The disclosed embodiment collects EEG data induced by ship radiation noise stimulation, pre-processes the EEG signals induced by different ship radiation noise stimulations to obtain EEG segmented data; performs EEG feature statistical analysis on the EEG segmented data to obtain an EEG data set; performs feature extraction and dimensionality reduction operations on the EEG data set to obtain EEG features; trains and tests the SVM model using the EEG features to obtain a trained SVM model; inputs the test data set into the trained SVM model to obtain auditory nerve features. According to the discrimination strategies adopted by different types of ships, a basis is provided for designing a more effective recognition mechanism, especially when classifying ships, a personalized recognition method can be adopted, thereby improving the adaptability and accuracy of the system.

The invention discloses an auditory neuron target extraction and positioning method based on a vertical model. Comprising the following steps: 1) preprocessing multi-modal data; 2) analyzing clinical symptom description in the current medical history by means of a Gemini vertical model; 3) constructing a multi-modal feature fusion module; and 4) dynamically analyzing auditory neurons of neuron images of different age groups. According to the method, screening and information identification are carried out on the neuron features of the specific area in the image, the difficulty that in the prior art, the positioning precision of auditory neurons in the image is low and the individual differences of patients cannot be dynamically adapted is overcome, and the analysis accuracy and efficiency are remarkably improved. Meanwhile, the dynamic adaptation capability of the technology can optimize an analysis strategy according to image signal characteristics of special crowds such as young people and old people, and fine analysis of an auditory nerve mechanism is promoted.