66 results about "Optical stimulation" patented technology

The invention relates to the technical field of nerve probes, and provides a four-mode integrated nerve probe and a preparation method thereof. The four-mode integrated nerve probe provided by the invention comprises a flexible substrate, an electric signal recording module, an ultrasonic stimulation module, a light stimulation module and a microfluidic channel. The electric signal recording module is used for recording electroneurographic signals, the ultrasonic stimulation module is used for ultrasonic stimulation, the optical stimulation module is used for optical stimulation and signal recording, and the microfluidic channel is filled with drugs through a microfluidic channel control port in the probe body and releases the drugs through a microfluidic channel outlet in the needle tip. According to the four-mode integrated nerve probe provided by the invention, multiple functions are integrated into one probe, so that comprehensive detection and regulation of a nervous system are realized, and the technical problems that a traditional nerve probe is single in function, inflammation is caused by a rigid material and multi-mode integration is insufficient are solved.

The present invention relates to a multiphoton imaging system, a multiphoton stimulation system and a multiphoton imaging and stimulation system. The system switches the system optical path to a multiphoton imaging optical path, an adaptive optical multiphoton imaging optical path, a multiphoton optical stimulation optical path or a multiphoton holographic optical stimulation optical path by adjusting the position of an electrically controlled movable reflector. Compared with the prior art, the present invention can achieve high-precision multiphoton imaging and single-cell precision multiphoton optical stimulation.

The invention relates to a control method of optical acupuncture, which comprises the following steps: a control system continuously applies a plurality of optical stimulation pulses lower than a nerve excitation threshold value, and target acupuncture point nerves enter a subcritical energy storage state through membrane potential superposition after synapse; laser output intensity is increased, and a directional threshold crossing pulse is emitted to trigger nerve discharge; judging the principal axis direction of local tissue fibers, and adjusting the laser incident angle, so that a light beam penetrates along the principal axis direction to trigger compliant tissue resonance; two beams of frequency differential laser are used for cross irradiation in a non-treatment acupoint area needing suppression to form fixed interference fringes, and a minimum power drop point is calculated to cover and suppress a target acupoint, so that the acupoint is always in an interference offset zone in the treatment process to form a selective function suppression window; a control system synchronously collects heart rate and respiration signals of a user, extracts respective periods to calculate a minimum common rhythm, sets a subsequent light stimulation rhythm as a physiological rhythm differential resynchronization frequency, and enables alternating resonance activation of different neural rhythms through phase staggering.

A system and method for determining and modifying the electromagnetic activity of a patient's heart includes a sensor array, a controller, software, and a stimulator array. The sensor array includes one or more sensors, such as an ECG electrode, that detect the electromagnetic activity of a patient's heart. The sensor array is in data communication with the controller. The controller runs software that outputs in human-format sensor data provided by the sensor array. The software receives data from the controller, analyzes the data, presents the data to the user, and sends the data to the stimulator array via a data communication link. The stimulator array includes one or more electromagnets and at least one or more light-emitting diodes. The stimulator array emits an electromagnetic (and / or light) field to modify the electromagnetic activity of a patient's heart based on the data it receives from the controller. The system can be portable.

Disclosed herein are systems and methods for the detection of neurological condition in a subject. The disclosed methods and systems provide, in certain embodiments, providing optical stimuli to a subject via a graphical display, capturing, using a camera, a plurality of images of eyes of the subject when the optical stimuli is provided to the subject via the graphical display, determining, by a processor, an occurrence of one or more ocular responses of structures of the eyes based on the plurality of images, identifying, by the processor, an occurrence of a neurological condition in the subject based on the one or more ocular responses, and providing the identification of the occurrence of the neurological condition to the subject via a graphical user interface.

A nanomaterial for optical stimulation of nerve cells, its preparation method and application. The present invention belongs to the field of nano-biological nerve medicine diagnosis and treatment, and mainly relates to the preparation of an organic / inorganic composite nanomaterial system with a capacitance effect. The present invention uses the supramolecular self-assembly of metal porphyrin to construct functionalized ZnTPyP-Au nanoparticles, which retain the physical and chemical properties of the original assembled molecule ZnTPyP while endowing the material with new optical properties. With ZnTPyP-Au as the core, a manganese oxide shell layer is grown and acts together with nerve cells to stimulate neuron activity using the photocapacitance property. The nanoparticles have good light response performance and electrical characteristics, and the present invention can be used for the treatment of neurological diseases and has important significance in clinical medicine.

A magnetic resonance-compatible programmable synchronized photostimulation system includes a main control unit and a stimulation execution unit. The main control unit is located outside the magnetic resonance scanning room, while the stimulation execution unit is located inside the scanning room and consists only of an LED light panel shielded by a magnetic field. The main control unit is configured to: receive photostimulation sequence parameters configured by the user in a modular manner through a graphical interface; receive a scan trigger signal from the magnetic resonance equipment, and automatically control the start and stop of the photostimulation sequence based on the trigger signal using hardware triggering; thereby achieving high-precision time synchronization between photostimulation and magnetic resonance scanning while maintaining magnetic resonance compatibility. This invention solves electromagnetic compatibility issues through a split architecture, achieves millisecond-level synchronization accuracy through hardware TTL triggering, and enhances experimental paradigm flexibility through modular programmable sequences, making it suitable for neuroscience research fields such as functional magnetic resonance imaging.

The invention belongs to the technical field of animal experiment instruments, and relates to an intelligent mouse cage for a mouse chronic unpredictable stimulation model and an experiment method. The mouse cage comprises an upper-layer cage body and a base, the upper-layer cage body is composed of an upper cover, a lower wall and a side wall, a stimulation module is arranged in the mouse cage, the stimulation module comprises a temperature stimulation module, a humidity stimulation module, an acousto-optic stimulation module, an inclined vibration stimulation module, a water and grain control module and a space stimulation module, and the stimulation module is controlled by a central controller; the intelligent mouse cage is compact in structure, and stimulation conditions can be automatically controlled. Moreover, various unpredictable stimulation can be completed in a single device, the intelligent mouse cage is easy to maintain and clean, and whether modeling succeeds or not is conveniently checked, so that the mouse welfare is ensured, the accuracy and repeatability of experimental data are improved, and manpower and experimental expenditure are effectively saved.

This invention, in one aspect, relates generally to methods for optically modulating pain in animals and human. The invention provides method for the use of opsin for modulating pain, wherein optical stimulation of specific neurons and / or other cells in targeted regions of the nervous system sensitized by opsin, using genetic technologies, leads to significant reduction of pain perception to noxious stimuli. Further, the invention provides a method for inhibition of pain without use of exogenous opsin, wherein visual stimulation of eye (having endogenous opsin) is carried out. The invention also includes device(s) for controlled modulation neural and / or cellular activities in brain, eye and peripheral nervous system in order to treat different forms of chronic pain.

A beauty device using skin impedance measurement and ultrasonic cross-frequency according to an embodiment of the present invention comprises: an electrical stimulator including an electrode, which transmits a current to the skin of a subject in order to measure the skin impedance of the subject and care for the skin condition of the subject analyzed on the basis of the skin impedance of the subject, and an LED, which irradiates the skin of the subject with light while the current is being transmitted to the skin of the subject; and a cross-frequency ultrasonic stimulator that measures the skin impedance of the subject and is provided with an ultrasonic generator that irradiates the skin of the subject with ultrasonic waves of cross-frequency in order to care for the skin condition of the subject analyzed on the basis of the skin impedance of the subject, wherein the beauty device can apply electrical stimulation, optical stimulation, and ultrasonic stimulation to the skin of the subject.

Disclosed is a method of selecting stimulations for a cochlear implant or an auditory implant. The method may include: capturing an acoustical signal; dividing the acoustical signal into a plurality of frequency bands; determining a mean acoustical energy for each frequency band; for each frequency band: comparing the mean acoustical energy with the mean acoustical energy determined for neighboring frequency bands; merging neighboring frequency bands having a difference between the mean acoustical energies that is less than an acoustical energy threshold value; selecting one or more types of stimulation to be applied to one or more locations in a cochlea or along an auditory nerve based on bandwidths of each frequency band. The one or more types of stimulation may be selected from: electrical stimulation, optical stimulation and opto-electrical stimulation, and the one or more locations in cochlea or along the auditory nerve may correspond to specific frequencies of the acoustical signal.

A multi-modal method of stimulation to the basal forebrain to enhance the neuroprotective effects of deep brain stimulation and photobiomodulation. Stimulation is generated by a lead that incorporates optical devices and electrodes placed either intracranially or intranasally. By using this combination therapy, both electrical and optical stimulation, and its therapeutic benefits, can be incorporated within one treatment regimen.

A Fourier-domain OCT apparatus for acquiring optoretinography data, comprising: a fixation target which fixes a gaze direction of an eye; an optical system which applies an optical stimulus which is confined to a portion of a retina of the eye whose location is controllable; an OCT imaging system which acquires OCT data from the retina; and a controller which: acquires a target location on the retina; uses the target location to control the optical system, while a position of the fixation target relative to the eye remains fixed, to apply the optical stimulus to a first portion of the retina at the target location; controls the OCT imaging system to acquire OCT data of a second portion of the retina which is stimulated by the applied optical stimulus during acquisition of the OCT data; and generates the ORG data based on the acquired OCT data.

Multi-modal fiber probe devices and processes for fabricating the same are described. In one example, a multi-modal fiber probe device can include a flexible tapered fiber probe structure having a micro-scale tip region at a first end and a macro-scale connector region at a second end opposite the first end. The multi-modal fiber probe device can further include an optical waveguide positioned in and extending through the flexible tapered fiber probe structure from the micro-scale tip region to the macro-scale connector region. The multi-modal fiber probe device can further include a microfluidic channel formed in and extending through the flexible tapered fiber probe structure from the micro-scale tip region to the macro-scale connector region.

An optical stimulation lead includes a lead body including a distal end, a distal portion, and a proximal portion; and an optical assembly attached to the distal end of the lead body. The optical assembly includes a light emitter; a feedthrough assembly including at least one ceramic block, at least one feedthrough pin extending through the at least one ceramic block and electrically coupled to the light emitter, and a metal housing attached to the at least one ceramic block; a metal tube attached to the feedthrough assembly and disposed around the light emitter; and an emitter cover disposed over the light emitter and coupled to the metal tube.

The invention discloses an OCT (optical coherence tomography) device for optical retina imaging. An OCT apparatus for acquiring optical retinal imaging data, comprising: an optical system applying an optical stimulus confined to a partition of the retina of an eye, the position of the partition being controllable; an OCT imaging system that acquires OCT data from the retina; and a controller that: acquires a duration of a physiological response of the retina in the optical retinal imaging data to be acquired; acquiring target locations on the retina and using these target locations to control the optical system to apply optical stimuli to respective first partitions of the retina at respective target locations; controlling the OCT imaging system to acquire respective OCT data of a respective second partition of the retina for each first partition for a duration indicated by the first indicator, the second partition being stimulated by an optical stimulus applied to the first partition; and generating ORG data based on the acquired OCT data.

The invention discloses a wireless photovoltaic visual cortex prosthesis system and method for total-blindness visual reconstruction, and the system comprises an external image processing unit which is used for collecting an environment image and generating a corresponding optical stimulation pattern; the near-infrared projection unit is connected with the external image processing unit and is used for converting the optical stimulation pattern into a near-infrared light stimulation sequence; the optical transparent cranial window assembly is used for transmitting the near-infrared light stimulation sequence to the visual cortex; and the flexible photovoltaic stimulation array is used for receiving the near-infrared light stimulation sequence through the optical transparent cranial window assembly and directly converting the near-infrared light stimulation sequence into an electrical stimulation signal for stimulating the primary visual cortex V1. By combining the flexible photovoltaic stimulation array with the optical transparent cranial window assembly, a wireless photoelectric link from the outside to the primary visual cortex is constructed, and a solution for reconstructing functional vision by directly stimulating the cortex without a leather-covered cable is provided for all-blind patients.

The invention relates to the technical field of implanted electrodes, in particular to a multi-mode composite neural electrode body, an electrode system and a preparation method. Comprising an insulating substrate, a plurality of electrical detection sites are arranged at the tip of the insulating substrate, and a leading-out bonding pad is arranged at the tail of the insulating substrate; a metal wiring layer; the fluid structure comprises a flow channel inlet, a first flow channel outlet and a second flow channel outlet, the flow channel inlet is a medicine inlet, and the first flow channel outlet is a medicine outlet; and the optical fiber penetrates in from the second flow channel outlet and extends to the first flow channel outlet, and an optical fiber light emitting position is formed at the front end of the optical fiber and penetrates out from the first flow channel outlet. By integrating the leading-out bonding pad, the metal wiring layer and the flow channel structure on the base body, electrical detection, electrical stimulation, optical detection, optical stimulation and drug delivery can be carried out after the slender piercing part pierces the human tissue, the freedom degree of a biological experiment is greatly improved, and a complex experiment scene can be dealt with.

The invention relates to a laser experiment platform for an in-situ photostimulation two-dimensional material of an AFM and a measurement method, and the platform comprises a clamping mechanism which is used for clamping, positioning and clamping laser generators with different radiuses; the lens element is used for amplifying or reducing the light source by adjusting the distance between the two lens frames so as to adjust the size of a light spot; the reflecting element is positioned below the sample mounting position of the platform supporting element and is used for reflecting the light beam transmitted by the lens element to irradiate to the bottom of the sample and applying in-situ light stimulation to the sample in the AFM characterization process; the platform supporting element comprises a height adjusting type objective table and a shading box, the shading box is inserted into the height adjusting type objective table, the lens element is installed in a shading box body, and a lens can move front and back in a non-perforated area of the shading box body under the action of the operating rod. In-situ light stimulation in the AFM characterization process is achieved, and the device can adapt to laser generators of various sizes; the device is small in size, and the problem of insufficient space in the AFM characterization process is solved.

A portable, wearable system and method for real-time determination and modification of a patient's cardiac electromagnetic activity. The device has a sensor array with ECG electrodes, a controller executing software, a stimulator array with at least one electromagnet and one light-emitting diode, and a power supply, optionally integrated into a belt or chest harness. The system continuously acquires ECG signals, calculates a force momentum Bion (β) based on cardiac cycle parameters, and generates synchronized electromagnetic and optical stimulation in real time, modulating output according to the patient's heart activity. Safety features include detection of electrode contact, noise, and arrhythmia, with automatic blocking of stimulation and alert generation. The device further provides wireless communication for data transmission and remote monitoring, and supports amplitude- and frequency-modulated stimulation profiles. The method includes real-time signal processing, adaptive stimulation, and configurable alerts for cardiac anomalies, enabling noninvasive cardiac monitoring and intervention.

The present invention relates to a module (22) for a microscope (12) with an XY stage (38) for determining a fixation point (20) of a user (16) and for controlling a microscope calibration function, comprising: an input interface (24) for receiving sensor data from an eye-tracking sensor (18) with information on a fixation point (20) of the user (16), for receiving operator data for operating the microscope calibration function, and for receiving marker data with information on an optical stimulus arranged on the XY stage (38); an analysis unit (26) for determining the fixation point (20) of the user (16) based on the sensor data and for determining a control command for controlling the microscope calibration function based on the operator data and performing a calibration based on the fixation point (20) and the marker data;and an output interface (28) for transmitting the control command to a control unit (36, 44) of the microscope (12) to control the XY stage (38). The present invention further relates to a method for calibrating a microscope and the use of a module with a microscope.

Embodiments of the present invention relate to an apparatus and a method for multimodal analysis of a three-dimensional biometric model such as an organoid. An apparatus according to one aspect comprises: a probe unit which probes the three-dimensional biometric model to obtain an electrical signal and applies electrical stimulation to the three-dimensional biometric model; an optical unit which optically observes the three-dimensional biometric model and applies optical stimulation to the three-dimensional biometric model; and a control unit which controls the probe unit and the optical unit, wherein the probe unit includes a probe extending in a certain direction, and the probe may include a plurality of electrodes arranged along the direction.

Provided herein are methods and systems for producing viral proteins and viral particles. In some cases, the methods and systems involve the use of optical stimulation for inducing expression of one or more viral proteins. In some cases, the methods and systems involve the use of optical switches for producing one or more viral proteins.

To provide a photoelectron synapse element having an optical active layer indicating a neuromorphic feature as well as enabling an optical responce of an infrared wavelength in order to be a recognition of a correct event, and provide a manufacturing method of them.SOLUTION: A photoelectron synapse element comprises an optical active layer in which a heterogeneous bonding is formed by contacting an inorganic quantum dot with a transition metal dichalcogenide of a secondary semiconductor material indicating a synapse characteristic by a light stimulus. Thus, a synapse reaction in responce to an optical signal of a near infrared wavelength can be made. By realizing a visual-brain function toe function of a human indicating the neuromorphic feature by an optical responce (a visual reaction) of the infrared wavelength in a single element with an optical detection feature that it is sensitively reacted at a high speed in the infrared wavelength signal, it can be easily adopted in an autonomous traveling mobility field.SELECTED DRAWING: Figure 1

A method of using a light beam steering transmissive and reflective element with an arbitrarily sized aperture comprising at least one layer of a insulating matrix modified for increased polarizability under electrical, magnetic or optical stimulation, between two or more substrates that can be electrically configured to provide signal modulation (optical, magnetic or electrical) that will control the wave fronts of incident light, thereby taking off-axis electromagnetic signals and aligning them to the aperture of a receiving element positioned near the device, or the reverse, sending signals originating behind the steering device to a variety of user-defined angles in two or more dimensions.

The present application discloses a multi-spectral fundus imaging system and method using dynamic visual stimulation, where the imaging system includes: a multi-spectral light source capable of emitting multiple different wavelengths; a mid-pass mirror being a reflecting mirror with a central hole penetrating the reflecting mirror; an imaging focusing lens group; an image acquisition device; and a controller configured to control the multi-spectral light source and the image acquisition device to work synchronously; a pattern sent by the optical stimulation device is transmitted to the fundus through the image focusing lens group and the central hole of the mid-pass mirror in sequence; an imaging light reflected from the fundus passes through the central hole of the mid-pass mirror and the imaging focusing lens group in sequence; the image acquisition device acquires the image to complete a multi-spectral fundus image acquisition.

The invention relates to a Fourier domain OCT device for optical retina imaging. A Fourier domain OCT device for acquiring optical retinal imaging data, comprising: an optical system that applies optical stimulation to the retina of an eye; an OCT imaging system that acquires OCT data from the retina; and a controller to: control the OCT imaging system to acquire OCT data for a plurality of partitions of the retina such that, for each partition, at least some OCT data from the partition is acquired after a respective optical stimulus has been applied to the partition; generating, based on the OCT data, respective ORG data for each partition indicative of a response of the partition to the optical stimulus; and storing the respective ORG data generated for each partition in association with a respective position in the field of view of the eye that is optically conjugated to the position of the partition on the retina.

The invention discloses a perimeter device and a view detection method, and relates to the technical field of medical detection.The perimeter device comprises a shell, a light source, a digital micromirror device, an imaging unit, an image acquisition unit and a controller; the digital micro-mirror device is arranged in the shell and is used for receiving light emitted by the light source and then generating an optical stimulation pattern; the imaging unit is installed in the shell and used for projecting the optical stimulation pattern to the eye fundus of the human eye for imaging; the image acquisition unit is mounted in the shell and is used for acquiring image data of human eyes; the controller is electrically connected with the image sensor and the digital micro-mirror device and used for calculating the rotation angle of the eyeball according to the image data of the human eyes and adjusting the position, where the optical stimulation graph is generated, on the digital micro-mirror device according to the rotation angle of the eyeball. And the image of the optical stimulation pattern projected to the eye fundus of the human eye through the imaging unit moves along with the eyeball.

A hybrid bioelectronic implantable device containing engineered cells for delivery of therapeutic agents to a subject to treat a medical condition of the subject. The device comprises an implantable device implantable inside the subject's body, wherein the implantable device comprises at least one cell housing containing the engineered cells; and an optical stimulating system within the at least one cell housing, wherein the optical stimulating system is configured to control production of at least one type of therapeutic agents by the engineered cells; wherein the medical condition of the subject comprises one of a sleep disorder, a circadian rhythm disorder, neuro disorders, infertilities, diabetes, obesity, eating disorders, cancers, bone marrow disorders, autoimmune disorders, addictive disorders.

Aspects of the present disclosure relate to systems and methods for combined optical stimulation and fluorescence imaging of a sample (e.g., a biological sample, such as in vivo animal tissue). Certain aspects relate to light source modules configured to emit light at a relatively high intensity (e.g., at least 2 W / cm2 at the sample plane). Certain aspects relate to imaging systems that have a relatively high numerical aperture (e.g., at least 0.4) and are configured to illuminate and image an area having a relatively large diameter (e.g., at least 2 mm). Certain aspects are directed to systems and methods for projecting two or more spatial patterns of illumination at two or more wavelengths on a sample concurrently (e.g., within a single frame of an imaging device, such as a camera).