7 results about "Optical stimulation" patented technology

A magnetic resonance-compatible programmable synchronized photostimulation system includes a main control unit and a stimulation execution unit. The main control unit is located outside the magnetic resonance scanning room, while the stimulation execution unit is located inside the scanning room and consists only of an LED light panel shielded by a magnetic field. The main control unit is configured to: receive photostimulation sequence parameters configured by the user in a modular manner through a graphical interface; receive a scan trigger signal from the magnetic resonance equipment, and automatically control the start and stop of the photostimulation sequence based on the trigger signal using hardware triggering; thereby achieving high-precision time synchronization between photostimulation and magnetic resonance scanning while maintaining magnetic resonance compatibility. This invention solves electromagnetic compatibility issues through a split architecture, achieves millisecond-level synchronization accuracy through hardware TTL triggering, and enhances experimental paradigm flexibility through modular programmable sequences, making it suitable for neuroscience research fields such as functional magnetic resonance imaging.

The present invention relates to a module (22) for a microscope (12) with an XY stage (38) for determining a fixation point (20) of a user (16) and for controlling a microscope calibration function, comprising: an input interface (24) for receiving sensor data from an eye-tracking sensor (18) with information on a fixation point (20) of the user (16), for receiving operator data for operating the microscope calibration function, and for receiving marker data with information on an optical stimulus arranged on the XY stage (38); an analysis unit (26) for determining the fixation point (20) of the user (16) based on the sensor data and for determining a control command for controlling the microscope calibration function based on the operator data and performing a calibration based on the fixation point (20) and the marker data;and an output interface (28) for transmitting the control command to a control unit (36, 44) of the microscope (12) to control the XY stage (38). The present invention further relates to a method for calibrating a microscope and the use of a module with a microscope.

Provided herein are methods and systems for producing viral proteins and viral particles. In some cases, the methods and systems involve the use of optical stimulation for inducing expression of one or more viral proteins. In some cases, the methods and systems involve the use of optical switches for producing one or more viral proteins.

A method of using a light beam steering transmissive and reflective element with an arbitrarily sized aperture comprising at least one layer of a insulating matrix modified for increased polarizability under electrical, magnetic or optical stimulation, between two or more substrates that can be electrically configured to provide signal modulation (optical, magnetic or electrical) that will control the wave fronts of incident light, thereby taking off-axis electromagnetic signals and aligning them to the aperture of a receiving element positioned near the device, or the reverse, sending signals originating behind the steering device to a variety of user-defined angles in two or more dimensions.

Disclosed herein is a system for optical stimulation of a target region in a living body. The system includes one or more probes subcutaneously placed adjacent to the target region connected to a microdevice subcutaneously placed in the living body. Each probe includes a biocompatible elastic strip, a flexible-length wire inside the elastic strip, and a plurality of light emitting elements mounted along the wire. The microdevice includes a processing unit connected to one or more light drivers coupled to the plurality of light emitting elements delivering light thereto. The processing unit includes a memory and a processor executing instructions stored in the memory to perform a method of optically stimulating cells of the target region by delivering a light beam with a predetermined set of characteristics to at least one light emitting element utilizing at least one light driver.

The application provides an optical imaging device and an optical imaging method. The optical imaging device comprises a light source module, a first galvanometer module, a second galvanometer module, a switching module and a main mirror body module. The second galvanometer module controls the two-dimensional deflection angle of the incident laser beam, realizes point-by-point scanning of the laser beam, adopts a two-photon excitation form of point-by-point scanning, improves the spatial resolution, increases the accuracy of optical stimulation, and accurately stimulates a single neuron. In addition, the holographic optical stimulation technology in the related art disperses laser light to multiple regions. Since two-photon excitation is proportional to the square of light intensity, a more expensive high-power femtosecond laser is often required. In the application, the laser beam is scanned point by point, so that each region receives sufficient stimulation energy, and a high-energy optical stimulation laser is not required, thereby reducing the cost and being more easily obtained.

This invention relates to the field of brain function monitoring and discloses a closed-loop transcranial photostimulation (tPBM) modulation method and system based on near-infrared brain response characteristics. First, fNIRS signals of the target brain region of the subject are acquired. After the fNIRS signals pass through the data pathway, preprocessing and windowing calculations are performed to extract dynamic response characteristics. By setting the difference detection between the baseline and stimulation periods, blood oxygen response indicators are calculated, and based on these indicators, the current brain region is identified as having enhanced, sluggish, inhibited, or fatigued responses, yielding the change in HbO. Through the real-time acquisition of HbO changes, features such as the instantaneous rate of change and peak response of indicators like Δ[HbO] and Δ[HbR] are extracted to construct an individual's "baseline-response" curve model for parameter optimization and control, completing the tPBM stimulation modulation. This invention solves the problems of equipment redundancy, spatial interference, poor synchronization, difficulty in achieving real-time coordination between intervention and imaging, and poor measurement stability and accuracy in existing technologies.