49 results about "Optical stimulation" patented technology

The invention relates to the technical field of nerve probes, and provides a four-mode integrated nerve probe and a preparation method thereof. The four-mode integrated nerve probe provided by the invention comprises a flexible substrate, an electric signal recording module, an ultrasonic stimulation module, a light stimulation module and a microfluidic channel. The electric signal recording module is used for recording electroneurographic signals, the ultrasonic stimulation module is used for ultrasonic stimulation, the optical stimulation module is used for optical stimulation and signal recording, and the microfluidic channel is filled with drugs through a microfluidic channel control port in the probe body and releases the drugs through a microfluidic channel outlet in the needle tip. According to the four-mode integrated nerve probe provided by the invention, multiple functions are integrated into one probe, so that comprehensive detection and regulation of a nervous system are realized, and the technical problems that a traditional nerve probe is single in function, inflammation is caused by a rigid material and multi-mode integration is insufficient are solved.

The invention relates to a control method of optical acupuncture, which comprises the following steps: a control system continuously applies a plurality of optical stimulation pulses lower than a nerve excitation threshold value, and target acupuncture point nerves enter a subcritical energy storage state through membrane potential superposition after synapse; laser output intensity is increased, and a directional threshold crossing pulse is emitted to trigger nerve discharge; judging the principal axis direction of local tissue fibers, and adjusting the laser incident angle, so that a light beam penetrates along the principal axis direction to trigger compliant tissue resonance; two beams of frequency differential laser are used for cross irradiation in a non-treatment acupoint area needing suppression to form fixed interference fringes, and a minimum power drop point is calculated to cover and suppress a target acupoint, so that the acupoint is always in an interference offset zone in the treatment process to form a selective function suppression window; a control system synchronously collects heart rate and respiration signals of a user, extracts respective periods to calculate a minimum common rhythm, sets a subsequent light stimulation rhythm as a physiological rhythm differential resynchronization frequency, and enables alternating resonance activation of different neural rhythms through phase staggering.

A system and method for determining and modifying the electromagnetic activity of a patient's heart includes a sensor array, a controller, software, and a stimulator array. The sensor array includes one or more sensors, such as an ECG electrode, that detect the electromagnetic activity of a patient's heart. The sensor array is in data communication with the controller. The controller runs software that outputs in human-format sensor data provided by the sensor array. The software receives data from the controller, analyzes the data, presents the data to the user, and sends the data to the stimulator array via a data communication link. The stimulator array includes one or more electromagnets and at least one or more light-emitting diodes. The stimulator array emits an electromagnetic (and / or light) field to modify the electromagnetic activity of a patient's heart based on the data it receives from the controller. The system can be portable.

Disclosed herein are systems and methods for the detection of neurological condition in a subject. The disclosed methods and systems provide, in certain embodiments, providing optical stimuli to a subject via a graphical display, capturing, using a camera, a plurality of images of eyes of the subject when the optical stimuli is provided to the subject via the graphical display, determining, by a processor, an occurrence of one or more ocular responses of structures of the eyes based on the plurality of images, identifying, by the processor, an occurrence of a neurological condition in the subject based on the one or more ocular responses, and providing the identification of the occurrence of the neurological condition to the subject via a graphical user interface.

A nanomaterial for optical stimulation of nerve cells, its preparation method and application. The present invention belongs to the field of nano-biological nerve medicine diagnosis and treatment, and mainly relates to the preparation of an organic / inorganic composite nanomaterial system with a capacitance effect. The present invention uses the supramolecular self-assembly of metal porphyrin to construct functionalized ZnTPyP-Au nanoparticles, which retain the physical and chemical properties of the original assembled molecule ZnTPyP while endowing the material with new optical properties. With ZnTPyP-Au as the core, a manganese oxide shell layer is grown and acts together with nerve cells to stimulate neuron activity using the photocapacitance property. The nanoparticles have good light response performance and electrical characteristics, and the present invention can be used for the treatment of neurological diseases and has important significance in clinical medicine.

A magnetic resonance-compatible programmable synchronized photostimulation system includes a main control unit and a stimulation execution unit. The main control unit is located outside the magnetic resonance scanning room, while the stimulation execution unit is located inside the scanning room and consists only of an LED light panel shielded by a magnetic field. The main control unit is configured to: receive photostimulation sequence parameters configured by the user in a modular manner through a graphical interface; receive a scan trigger signal from the magnetic resonance equipment, and automatically control the start and stop of the photostimulation sequence based on the trigger signal using hardware triggering; thereby achieving high-precision time synchronization between photostimulation and magnetic resonance scanning while maintaining magnetic resonance compatibility. This invention solves electromagnetic compatibility issues through a split architecture, achieves millisecond-level synchronization accuracy through hardware TTL triggering, and enhances experimental paradigm flexibility through modular programmable sequences, making it suitable for neuroscience research fields such as functional magnetic resonance imaging.

The invention belongs to the technical field of animal experiment instruments, and relates to an intelligent mouse cage for a mouse chronic unpredictable stimulation model and an experiment method. The mouse cage comprises an upper-layer cage body and a base, the upper-layer cage body is composed of an upper cover, a lower wall and a side wall, a stimulation module is arranged in the mouse cage, the stimulation module comprises a temperature stimulation module, a humidity stimulation module, an acousto-optic stimulation module, an inclined vibration stimulation module, a water and grain control module and a space stimulation module, and the stimulation module is controlled by a central controller; the intelligent mouse cage is compact in structure, and stimulation conditions can be automatically controlled. Moreover, various unpredictable stimulation can be completed in a single device, the intelligent mouse cage is easy to maintain and clean, and whether modeling succeeds or not is conveniently checked, so that the mouse welfare is ensured, the accuracy and repeatability of experimental data are improved, and manpower and experimental expenditure are effectively saved.

A beauty device using skin impedance measurement and ultrasonic cross-frequency according to an embodiment of the present invention comprises: an electrical stimulator including an electrode, which transmits a current to the skin of a subject in order to measure the skin impedance of the subject and care for the skin condition of the subject analyzed on the basis of the skin impedance of the subject, and an LED, which irradiates the skin of the subject with light while the current is being transmitted to the skin of the subject; and a cross-frequency ultrasonic stimulator that measures the skin impedance of the subject and is provided with an ultrasonic generator that irradiates the skin of the subject with ultrasonic waves of cross-frequency in order to care for the skin condition of the subject analyzed on the basis of the skin impedance of the subject, wherein the beauty device can apply electrical stimulation, optical stimulation, and ultrasonic stimulation to the skin of the subject.

Disclosed is a method of selecting stimulations for a cochlear implant or an auditory implant. The method may include: capturing an acoustical signal; dividing the acoustical signal into a plurality of frequency bands; determining a mean acoustical energy for each frequency band; for each frequency band: comparing the mean acoustical energy with the mean acoustical energy determined for neighboring frequency bands; merging neighboring frequency bands having a difference between the mean acoustical energies that is less than an acoustical energy threshold value; selecting one or more types of stimulation to be applied to one or more locations in a cochlea or along an auditory nerve based on bandwidths of each frequency band. The one or more types of stimulation may be selected from: electrical stimulation, optical stimulation and opto-electrical stimulation, and the one or more locations in cochlea or along the auditory nerve may correspond to specific frequencies of the acoustical signal.

An optical stimulation lead includes a lead body including a distal end, a distal portion, and a proximal portion; and an optical assembly attached to the distal end of the lead body. The optical assembly includes a light emitter; a feedthrough assembly including at least one ceramic block, at least one feedthrough pin extending through the at least one ceramic block and electrically coupled to the light emitter, and a metal housing attached to the at least one ceramic block; a metal tube attached to the feedthrough assembly and disposed around the light emitter; and an emitter cover disposed over the light emitter and coupled to the metal tube.

The invention discloses an OCT (optical coherence tomography) device for optical retina imaging. An OCT apparatus for acquiring optical retinal imaging data, comprising: an optical system applying an optical stimulus confined to a partition of the retina of an eye, the position of the partition being controllable; an OCT imaging system that acquires OCT data from the retina; and a controller that: acquires a duration of a physiological response of the retina in the optical retinal imaging data to be acquired; acquiring target locations on the retina and using these target locations to control the optical system to apply optical stimuli to respective first partitions of the retina at respective target locations; controlling the OCT imaging system to acquire respective OCT data of a respective second partition of the retina for each first partition for a duration indicated by the first indicator, the second partition being stimulated by an optical stimulus applied to the first partition; and generating ORG data based on the acquired OCT data.

The invention discloses a wireless photovoltaic visual cortex prosthesis system and method for total-blindness visual reconstruction, and the system comprises an external image processing unit which is used for collecting an environment image and generating a corresponding optical stimulation pattern; the near-infrared projection unit is connected with the external image processing unit and is used for converting the optical stimulation pattern into a near-infrared light stimulation sequence; the optical transparent cranial window assembly is used for transmitting the near-infrared light stimulation sequence to the visual cortex; and the flexible photovoltaic stimulation array is used for receiving the near-infrared light stimulation sequence through the optical transparent cranial window assembly and directly converting the near-infrared light stimulation sequence into an electrical stimulation signal for stimulating the primary visual cortex V1. By combining the flexible photovoltaic stimulation array with the optical transparent cranial window assembly, a wireless photoelectric link from the outside to the primary visual cortex is constructed, and a solution for reconstructing functional vision by directly stimulating the cortex without a leather-covered cable is provided for all-blind patients.

The invention relates to the technical field of implanted electrodes, in particular to a multi-mode composite neural electrode body, an electrode system and a preparation method. Comprising an insulating substrate, a plurality of electrical detection sites are arranged at the tip of the insulating substrate, and a leading-out bonding pad is arranged at the tail of the insulating substrate; a metal wiring layer; the fluid structure comprises a flow channel inlet, a first flow channel outlet and a second flow channel outlet, the flow channel inlet is a medicine inlet, and the first flow channel outlet is a medicine outlet; and the optical fiber penetrates in from the second flow channel outlet and extends to the first flow channel outlet, and an optical fiber light emitting position is formed at the front end of the optical fiber and penetrates out from the first flow channel outlet. By integrating the leading-out bonding pad, the metal wiring layer and the flow channel structure on the base body, electrical detection, electrical stimulation, optical detection, optical stimulation and drug delivery can be carried out after the slender piercing part pierces the human tissue, the freedom degree of a biological experiment is greatly improved, and a complex experiment scene can be dealt with.

The invention relates to a laser experiment platform for an in-situ photostimulation two-dimensional material of an AFM and a measurement method, and the platform comprises a clamping mechanism which is used for clamping, positioning and clamping laser generators with different radiuses; the lens element is used for amplifying or reducing the light source by adjusting the distance between the two lens frames so as to adjust the size of a light spot; the reflecting element is positioned below the sample mounting position of the platform supporting element and is used for reflecting the light beam transmitted by the lens element to irradiate to the bottom of the sample and applying in-situ light stimulation to the sample in the AFM characterization process; the platform supporting element comprises a height adjusting type objective table and a shading box, the shading box is inserted into the height adjusting type objective table, the lens element is installed in a shading box body, and a lens can move front and back in a non-perforated area of the shading box body under the action of the operating rod. In-situ light stimulation in the AFM characterization process is achieved, and the device can adapt to laser generators of various sizes; the device is small in size, and the problem of insufficient space in the AFM characterization process is solved.

A portable, wearable system and method for real-time determination and modification of a patient's cardiac electromagnetic activity. The device has a sensor array with ECG electrodes, a controller executing software, a stimulator array with at least one electromagnet and one light-emitting diode, and a power supply, optionally integrated into a belt or chest harness. The system continuously acquires ECG signals, calculates a force momentum Bion (β) based on cardiac cycle parameters, and generates synchronized electromagnetic and optical stimulation in real time, modulating output according to the patient's heart activity. Safety features include detection of electrode contact, noise, and arrhythmia, with automatic blocking of stimulation and alert generation. The device further provides wireless communication for data transmission and remote monitoring, and supports amplitude- and frequency-modulated stimulation profiles. The method includes real-time signal processing, adaptive stimulation, and configurable alerts for cardiac anomalies, enabling noninvasive cardiac monitoring and intervention.

The present invention relates to a module (22) for a microscope (12) with an XY stage (38) for determining a fixation point (20) of a user (16) and for controlling a microscope calibration function, comprising: an input interface (24) for receiving sensor data from an eye-tracking sensor (18) with information on a fixation point (20) of the user (16), for receiving operator data for operating the microscope calibration function, and for receiving marker data with information on an optical stimulus arranged on the XY stage (38); an analysis unit (26) for determining the fixation point (20) of the user (16) based on the sensor data and for determining a control command for controlling the microscope calibration function based on the operator data and performing a calibration based on the fixation point (20) and the marker data;and an output interface (28) for transmitting the control command to a control unit (36, 44) of the microscope (12) to control the XY stage (38). The present invention further relates to a method for calibrating a microscope and the use of a module with a microscope.

Embodiments of the present invention relate to an apparatus and a method for multimodal analysis of a three-dimensional biometric model such as an organoid. An apparatus according to one aspect comprises: a probe unit which probes the three-dimensional biometric model to obtain an electrical signal and applies electrical stimulation to the three-dimensional biometric model; an optical unit which optically observes the three-dimensional biometric model and applies optical stimulation to the three-dimensional biometric model; and a control unit which controls the probe unit and the optical unit, wherein the probe unit includes a probe extending in a certain direction, and the probe may include a plurality of electrodes arranged along the direction.

Provided herein are methods and systems for producing viral proteins and viral particles. In some cases, the methods and systems involve the use of optical stimulation for inducing expression of one or more viral proteins. In some cases, the methods and systems involve the use of optical switches for producing one or more viral proteins.

A method of using a light beam steering transmissive and reflective element with an arbitrarily sized aperture comprising at least one layer of a insulating matrix modified for increased polarizability under electrical, magnetic or optical stimulation, between two or more substrates that can be electrically configured to provide signal modulation (optical, magnetic or electrical) that will control the wave fronts of incident light, thereby taking off-axis electromagnetic signals and aligning them to the aperture of a receiving element positioned near the device, or the reverse, sending signals originating behind the steering device to a variety of user-defined angles in two or more dimensions.

The invention discloses a perimeter device and a view detection method, and relates to the technical field of medical detection.The perimeter device comprises a shell, a light source, a digital micromirror device, an imaging unit, an image acquisition unit and a controller; the digital micro-mirror device is arranged in the shell and is used for receiving light emitted by the light source and then generating an optical stimulation pattern; the imaging unit is installed in the shell and used for projecting the optical stimulation pattern to the eye fundus of the human eye for imaging; the image acquisition unit is mounted in the shell and is used for acquiring image data of human eyes; the controller is electrically connected with the image sensor and the digital micro-mirror device and used for calculating the rotation angle of the eyeball according to the image data of the human eyes and adjusting the position, where the optical stimulation graph is generated, on the digital micro-mirror device according to the rotation angle of the eyeball. And the image of the optical stimulation pattern projected to the eye fundus of the human eye through the imaging unit moves along with the eyeball.

A hybrid bioelectronic implantable device containing engineered cells for delivery of therapeutic agents to a subject to treat a medical condition of the subject. The device comprises an implantable device implantable inside the subject's body, wherein the implantable device comprises at least one cell housing containing the engineered cells; and an optical stimulating system within the at least one cell housing, wherein the optical stimulating system is configured to control production of at least one type of therapeutic agents by the engineered cells; wherein the medical condition of the subject comprises one of a sleep disorder, a circadian rhythm disorder, neuro disorders, infertilities, diabetes, obesity, eating disorders, cancers, bone marrow disorders, autoimmune disorders, addictive disorders.

The system for optical stimulation can include: a light source, a display module, a steering module, a sensor module, and a processing system. In variants, the system can function to project a time series of patterned light frames onto the retina of an eye (e.g., onto optogenetically modified cells in the retina, onto a retinal implant, etc.).

The application discloses a multi-site two-photon imaging stimulation device coupled by non-parallel light axes, which comprises a femtosecond laser, a laser scanning device and at least two optical branches; the optical branch comprises a first focusing optical element, a mirror and a second focusing optical element; the femtosecond laser emitted by the femtosecond laser enters the laser scanning device, the laser scanning device repeatedly scans the femtosecond laser between multiple scanning intervals, and the femtosecond laser of each scanning interval reaches a corresponding target site after passing through a corresponding optical branch; the femtosecond laser entering the optical branch is reflected to the second focusing optical element after being focused for the first time by the first focusing optical element, and reaches the corresponding target site visual field plane after being focused for the second time. The multi-site two-photon imaging stimulation device coupled by non-parallel light axes provided by the application is suitable for two-photon imaging or optical stimulation on multiple planar visual field regions with spatial angles located on a curved sample.

The utility model discloses a composite microstructure lens and glasses. The composite microstructure lens comprises a lens body, and the lens body is provided with an optical center and an edge. In the direction extending from the optical center to the edge, the lens body is provided with a central area and a microstructure area which are sequentially arranged around the optical center; the central area comprises a bright vision area and a transition zone, and the bright vision area surrounds the optical center; the transition zone is located between the bright vision zone and the microstructure zone and connected with the bright vision zone and the microstructure zone. And the microstructure array is arranged in the microstructure area, is connected with the lens body and is used for being matched with the lens body to generate an optical stimulation signal. By introducing the transition zone between the bright vision area and the microstructure area, high adaptability and compliance can be maintained in a smaller bright vision area, and the functionality influencing myopia progress can be enhanced under the condition that the lens wearing adaptability is not influenced.

Systems, devices, and methods for optically stimulating optoreactive tissue samples are provided. The optical stimulation systems include coherent light sources arrayed in a housing, each coherent light source being configured to precisely focus and align a photon beam on an optoreactive tissue sample in a multi-well cartridge, delivering optical parameters that stimulate physiological responses. The systems, devices, and methods enable parallel stimulation of numerous tissue samples without crosstalk and while maintaining thermal stability, advantageously reducing data acquisition time and operator burden.

Methods and systems for cross-domain controlled stimulation of biological dynamics by AI iterative optimization physical patterns for migrating structured patterns (including crystals, semiconductors, and related processes) from physical or mineral systems to target biological systems to guide their measurable dynamic processes, such as growth, migration, proliferation, branching, and self-organization. The present application generates a defect and anisotropy mapping or descriptor delta (x) from a physical source and converts a derived stimulation pattern or stimulation recipe under constrained conditions into an executable stimulation protocol, which may include electrical stimulation or electro-physical stimulation, light stimulation, chemical stimulation, thermal stimulation or mechanical stimulation, or may be in a multi-modal form, meanwhile, the biological constraint and the executable and safety constraint of the experimental device are met; applying the stimulation protocol to a target biological system and obtaining observation data through a sensor and / or visual means (photo, video, time-lapse photography) to extract quantitative features and calculate a result indicator that can be compared to a baseline; subsequent tests are selected under constraint conditions by an artificial intelligence assisted decision engine to maximize information utility and achieve improvements while using stop rules to limit low-yield experimental activities and maintain comparability and repeatability between different runs.

The utility model discloses a multifunctional electronic bird repelling device which comprises a shell, a motor is arranged in the shell, a base is arranged at the bottom of the shell, a water tank is arranged in a water tank, and an atomization assembly is arranged on the outer side of the water tank. An atomizing nozzle in the atomizing assembly can uniformly spray a chemical odorant into the air around the equipment to ensure that the whole repelling range is covered, so that the repelling effect can be improved to the greatest extent, birds have no place to hide, the birds are scared by using strong light beams or flash of a light lamp, and the bird repelling effect is improved. The optical stimulation can simulate reflection of sunlight or other natural light rays, birds feel uncomfortable and are prevented from entering a protected area, meanwhile, an internal motor drives a top rotating shaft and a rotating rod to rotate, a loudspeaker at the tail end emits harsh sound waves or warning sounds, the sounds can interfere normal activities of the birds, and the birds are prevented from entering the protected area. And the vehicles are far away from the driving area.

An eye movement measuring apparatus includes: an interference device; an infrared (IR) light source that emits IR to irradiate an eye of a patient; an imaging device that measures IR light reflected by the eye of the patient; and a controller operable to control operation of each of the interference device, the infrared light source, and the imaging device. The controller may further operate the disrupting device to obscure optical stimuli to selectively permit or prevent optical stimuli from being perceived by the patient's eye. The controller may operate the IR source to illuminate the patient's eye with infrared light and operate the imaging device to generate an image of the patient's eye from reflected IR light from the patient's eye.

The invention relates to processing techniques for optical retinal imaging. A computer-implemented method for processing respective phase components of a first OCT image and a second OCT image of a series of OCT images of a common portion of the retina acquired by a Fourier domain OCT imaging system after stimulation of the common portion by optical stimulation, the common portion includes a layer of the retina whose thickness varies during acquisition of a series of OCT images to determine an indication of a position of a boundary of the layer in an axial direction in the OCT images, the method comprises: processing a phase component of the first OCT image and a phase component of the second OCT image to calculate a velocity profile indicative of a distribution of velocities in an axial direction within the common portion of the retina; and determining the indication based on the calculated velocity profile.

A reactor, reactor system, and methods of use thereof are disclosed. The reactor includes a reactor tube, a waveguide, and a gas manifold. The reactor tube defines a reaction chamber for receiving an active solid material. The waveguide includes an optically transmitting material and an end positioned within the reaction chamber. A permeable material restraint is positioned at an end of the reactor tube that allows for gas to pass through for measurements by a measurement device. The gas manifold adjoins an end of the reactor tube opposite the material restraint. The gas manifold is configured to accommodate the waveguide and to direct gas into the reaction chamber. The method includes utilizing the reactor and / or the reactor system to determine responses of the active solid material to a transient by detecting properties of light and / or gas, resulting from interaction of the active solid material with the transient.