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393 results about "Microelectrode" patented technology

A microelectrode is an electrode used in electrophysiology either for recording neural signals or for the electrical stimulation of nervous tissue (they were developed by Gilbert Ling and Ralph W. Gerard). Pulled glass pipettes with tip diameters of 0.5 μm or less are usually filled with 3 molar potassium chloride solution as the electrical conductor. When the tip penetrates a cell membrane the lipids in the membrane seal onto the glass, providing an excellent electrical connection between the tip and the interior of the cell, which is apparent because the microelectrode becomes electrically negative compared to the extracellular solution. There are also microelectrodes made with insulated metal wires, made from inert metals with high Young modulus such as tungsten, stainless steel, or Platinum-iridium alloy and coated with glass or polymer insulator with exposed conductive tips. These are most used for recording from the external side of the cell membrane, More recent advances in lithography have produced silicon based microelectrodes.

Intelligent pipeline corrosion monitoring and protection system

The invention relates to the technical field of corrosion monitoring, in particular to an intelligent pipeline corrosion monitoring and protection system which comprises a dynamic potential disturbance measurement module, a local microcell scanning module, a corrosion rate calculation module, a corrosion risk distribution analysis module and an environmental parameter compensation module. According to the invention, accurate measurement is realized, the spatial resolution is improved, and the current response change rate is calculated by measuring the reference potential of the surface of the pipeline, applying instantaneous disturbance, combining current change differential operation, dynamically tracking the corrosion process, improving the real-time response capability and arranging a microelectrode array to cover corrosion hot spots; the corrosion current density is solved by combining the electrochemical characteristics of the material, the corrosion rate is dynamically predicted, regional distribution is analyzed based on the change of the corrosion rate, the corrosion risk assessment precision is optimized, environmental factors are monitored, disturbance parameters are adjusted, interference is compensated, the monitoring accuracy under different working conditions is ensured, and data stability and protection measure optimization are guaranteed.
Owner:YANAN QIBEI PETROLEUM ENG TECH SERVICE CO LTD

Full-automatic filling and tail sealing method and system based on image recognition analysis

The invention discloses a full-automatic filling and tail sealing method and system based on image recognition analysis, and relates to the technical field of image analysis, and the method comprises the following steps: extracting fluid dynamic control parameters and bubble group dynamic characteristic parameters; according to fluid dynamic control parameters, the annular microelectrode array is controlled to generate a directional electric field, and the liquid flowing state is regulated and controlled; ultrasonic action parameters are determined according to the bubble group dynamic characteristic parameters, and a frequency-adjustable ultrasonic generator is controlled to output ultrasonic modulation pulses; detecting the temperature distribution of the sealing area of the container, and applying differential heat sealing parameters to different temperature areas; and establishing a multi-layer perception neural network optimization controller, and optimizing a control parameter combination by taking the quality index of the filling and end-capping process as an optimization target. The filling method combining image recognition and electric field regulation and control is adopted, accurate control over the liquid flowing state is achieved, the problem that in the traditional filling process, liquid drawing and flow cutoff are not accurate is solved, and the filling precision and efficiency are improved.
Owner:ZHEJIANG JIEDU INTELLIGENT MASCH TECH CO LTD

Cognitive function in-vitro simulation method based on microelectrode array and brain organs and application of cognitive function in-vitro simulation method

ActiveCN120272421AMicrobiological testing/measurementDrug screeningHigher-level cognitive functionsElectro stimulation
The invention provides a cognitive function in-vitro simulation method based on a microelectrode array (MEA) and brain organs and application of the cognitive function in-vitro simulation method, and belongs to the crossing field of brain organ in-vitro model construction, neural engineering, brain-like intelligence and the like. In an in-vitro environment, external signal (such as sound) information is converted into electrical stimulation input capable of being perceived by brain organs in an MEA electrical stimulation mode, so that the brain organs gradually learn and identify external signals in repeated electrical stimulation; after elution stimulation for a period of time, the reduction condition of recognition accuracy is observed, namely, the important memory and forgetting process in the cognitive function is simulated. According to the method, the electrophysiological response and the biological mechanism change of the brain organs under external electrical stimulation can be quantitatively evaluated, and a new possibility is provided for exploring the advanced cognitive function by utilizing the brain organs.
Owner:HANGZHOU SEVENTH PEOPLES HOSPITAL

Silver coating adhesive force detection method based on multi-frequency impedance imaging

The invention relates to the technical field of material detection, in particular to a silver coating adhesive force detection method based on multi-frequency impedance imaging, which comprises the following steps: applying a dual-mode multi-frequency excitation signal to the surface of a silver coating through an attached microelectrode array, synchronously acquiring voltage-current response data, and generating a dual-mode multi-frequency impedance original data set; performing time-varying impedance phase-locked separation on the dual-mode multi-frequency impedance original data set, extracting a dynamic impedance component of a coating-matrix interface region, and reconstructing a three-dimensional sub-interface impedance distribution diagram; and outputting an adhesive force quantized value through an oscillation frequency-adhesive force conversion model according to the spatial oscillation frequency characteristics of the impedance phase in the three-dimensional sub-interface impedance distribution diagram. According to the invention, a double-phase-locked loop system is adopted to realize the time-varying component demodulation of the impedance response of the silver coating-matrix interface, the low-frequency dynamic impedance signal modulated by silver ion migration is effectively extracted, and the weak change of the interface bonding state is sensitively reflected.
Owner:SHENZHEN HAILI SURFACE TECH CO LTD

System and method for detecting free carbon particles in transformer oil based on microelectrode array

The invention provides a system and method for detecting free carbon particles in transformer oil based on a microelectrode array, and the system comprises a sampling module which comprises an oil inlet pipeline and a filtering device, an oil sample is conveyed to a microelectrode array sensor module from a transformer oil tank through the oil inlet pipeline, and the filtering device is located in the oil inlet pipeline; a filter membrane is arranged in the filter device to remove impurities in the oil sample; the microelectrode array sensor module comprises a microelectrode array sensor, the microelectrode array sensor is nanoelectrodes arranged on a silicon substrate, the surface of the microelectrode array sensor is coated with graphene oxide to adsorb free carbon particles in an oil sample, and when the free carbon particles are adsorbed to the surface of the microelectrode array sensor, an adsorption signal is generated; and the signal processing unit is used for extracting the characteristic frequency and intensity of the vibration of the carbon particles in the adsorption signal, and classifying the carbon particles according to the characteristic frequency and intensity of the carbon particles. The device is compact in structure, the maintenance cost is reduced, and the operation process is simplified.
Owner:STATE GRID JIANGSU ELECTRIC POWER CO LTD MAINTENANCE BRANCH +1

Multi-brain organ electron complex and construction method and application thereof

The invention discloses a multi-brain organ electron complex as well as a construction method and application thereof. The multi-brain organ electronic complex comprises a microelectrode array and a fusion organ attached to the surface of a chip electrode of the microelectrode array through a PDMS film, and the fusion organ can grow for more than or equal to 120 days through culture. The PDMS film is attached to the surface of the MEA chip electrode, so that the stability of combination of the MEA chip electrode and the organoid is remarkably enhanced, the construction efficiency of a multi-brain organoid electron complex is improved, and the continuity of neural signal detection is improved; a high-performance model platform is provided for multi-brain organ research, and the method has a wide application prospect.
Owner:TIANJIN UNIV

Dynamic monitoring system for spinal cord injury reconstruction process

The invention relates to the field of medical dynamic monitoring, in particular to a dynamic monitoring system for a spinal cord injury reconstruction process. Comprising an acquisition and fusion module, a dynamic modeling module, a function evaluation module and an adaptation control module. According to the system, nerve and muscle electrophysiological signals are collected through a wearable surface electrode and a flexible microelectrode array, timing sequence errors are corrected in combination with a calibration sample, and multi-modal signal fusion is achieved. And constructing a topological sequence and time sequence dependence structure, and extracting an incubation period, an activation gradient and response dispersion by adopting a time sequence convolutional network. And identifying function transition and abnormal compensation behaviors through a function evaluation module, and outputting a neural pathway response sequence diagram. And the sampling frequency, the feature weight and the evaluation period are dynamically adjusted based on a Bayesian optimization strategy, and self-adaptive optimization of the monitoring strategy is realized. Therefore, precise modeling and efficient tracking of the neural pathway function reconstruction process are realized.
Owner:南昌大学第一附属医院

High-flux and high-efficiency cell extrusion microfluidic system and particle introduction method

The invention relates to the technical field of microfluidics, in particular to a high-throughput and high-efficiency cell extrusion microfluidic system and a particle introduction method. And a closed-loop control system integrating real-time cell deformation sensing, dynamic parameter decision and physical extrusion and alternating electric field cooperative application is constructed. The chip is provided with an inlet shunting device, a micro-channel and a channel structure of a microelectrode. The method comprises the steps of real-time deformation image acquisition and analysis and dynamic extrusion parameter decision and cooperative application. The invention provides a high-flux and high-efficiency cell extrusion microfluidic system and a particle introduction method, and aims to solve the problems that the drug loading efficiency and the survival rate are difficult to consider due to heterogeneity in the existing cell extrusion technology and a physical extrusion and electroporation coordinated regulation strategy is lacked, so that personalized precise treatment of cells is realized, and the cell quality is improved. The drug loading efficiency, the cell survival rate and the high throughput are obviously improved.
Owner:HENAN UNIVERSITY OF TECHNOLOGY

Collaborative light regulation and control decision-making method and system

The invention discloses a collaborative light regulation and control decision method and system, and relates to the technical field of intelligent regulation and control of plant factory light environments, and the system comprises a plant physiology monitoring unit which is provided with a non-invasive microelectrode array and a hyperspectral imager; and the environment sensing unit is used for collecting illumination intensity, spectrum, temperature, humidity and carbon dioxide concentration data. According to the collaborative light regulation and control decision-making method and system, fusion of multi-source heterogeneous data is realized through a pulse time sequence coding mechanism, and the problem that environmental parameters and plant physiological statuses are difficult to collaboratively analyze in the prior art is solved; based on a dynamic optimization architecture of double-alliance Nash equilibrium, autonomous collaborative decision-making of spectrum parameters can be completed in a short time, and compared with a traditional preset light formula, the response speed is improved; decision effectiveness can be synchronously guaranteed on the virtual model and biological entity level, the light suppression misjudgment rate is reduced, and meanwhile the plant light energy utilization rate is stably improved.
Owner:SANMING UNIV +1

Bone organ chip loaded with microelectrode array and use method

The invention discloses a bone organ chip loaded with a microelectrode array and a use method, and relates to the technical field of organ chips, the bone organ chip is made of a polydimethylsiloxane material, and the bone organ chip comprises a three-layer structure: a top layer, a middle layer and a bottom layer; the middle layer comprises two blood vessel micro-channels, two osteoblast micro-channels and a neuron micro-channel, the channels are separated through columns and micro-columns, and cell interaction in a bone micro-environment is simulated; a microelectrode array is arranged on the top layer and is used for monitoring electrical activity of neurons in real time; the bottom layer is provided with a pneumatic valve which can control opening and closing of the micro-channel. According to the invention, nerve and blood vessel channels are introduced, a nerve-blood vessel-immunoregulation bone microenvironment is constructed, physiological processes such as osteogenesis-blood vessel formation coupling and the like are embodied, intervals of different sizes can enhance intercellular crosstalk and allow blood vessels and neuron axons to selectively pass through, so that the chip can simulate a complex microenvironment of bone tissues, and the microenvironment of the bone tissues can be simulated; and an efficient and accurate in-vitro model is provided for bone disease mechanism research and drug development.
Owner:CHINA JAPAN FRIENDSHIP HOSPITAL

Neural foundation models for brain-computer interface

A method and system for decoding speech based on recorded brain signals is provided. The method can include receiving recorded brain signals via a microelectrode array. The method can include extracting one or more features from the recorded brain signals. The method can include converting the one or more extracted features into one or more feature embeddings. The method can include transforming, by one or more encoders, the one or more feature embeddings. The method can include predicting, by one or more decoders, phonemes based on the one or more transformed feature embeddings. The method can include predicting speech based on the predicted phonemes.
Owner:PRECISION NEUROSCIENCE CORP

Method of implantation of a medical device into neural tissue

A method of providing a channel in nervous tissue filled with an aqueous gel for implantation of a microelectrode or other medical device lacking sufficient physical stability for direct implantation by insertion, comprises providing an apparatus comprising an oblong rigid pin covered by a dry gel forming agent; locating a target in the tissue; defining a straight insertion path a desired tissue insertion point and the target; aligning the pin with its end foremost with the insertion path; inserting the pin into the tissue to a position near or at the target; allowing sufficient time to pass for a gel to be formed around the pin, withdrawing the pin. Also disclosed is a corresponding channel; a method of implantation of a microelectrode or microprobe into nervous tissue via the channel; a corresponding method of implantation of living cells; a corresponding apparatus for forming the channel.
Owner:NEURONANO AB

Memory enhancement system and method based on closed-loop regulation brain-computer interface

The invention provides a memory enhancement system and method based on a closed-loop regulation brain-computer interface, and relates to the technical field of medical equipment, and the system comprises a multi-channel neural activity detection unit which is used for collecting the field potential waveforms of a plurality of brain regions, related to memory cognition, of the brain of a target object; the electroencephalogram signal analysis unit is used for sending a corresponding control signal to the electrical stimulation output unit under the condition that the field potential waveform of any target brain region meets a preset triggering condition; and the electrical stimulation output unit is used for applying electrical stimulation to the target brain area under the condition of receiving the control signal sent by the electroencephalogram signal analysis unit. According to the memory enhancement system and method based on the closed-loop regulation and control brain-computer interface provided by the invention, by synchronously implanting the microelectrodes of the hippocampus multi-subregion and the temporal lobe cortex of the brain in a cross-scale manner, the waveform information of the memory coding spike ripple is effectively identified, and the accurate stimulation output moment is fed back; and a customized closed-loop brain-computer interface system memory regulation strategy can be provided for different individuals.
Owner:TSINGHUA UNIVERSITY

Graphene hydrogel neural microelectrode and preparation method thereof

The invention relates to a graphene hydrogel neural microelectrode and a preparation method thereof.The neural microelectrode comprises a long-strip-shaped electrode body, the electrode body comprises an insulating substrate layer, a conductive layer and an insulating covering layer, and the conductive layer is wrapped and sealed by the insulating substrate layer and the insulating covering layer; a contact window is arranged at one end, close to the electrode body, of the insulating covering layer, a conductive expansion layer made of graphene hydrogel is arranged below the contact window and the insulating covering layer on the periphery of the contact window, the conductive expansion layer is electrically connected with the conductive layer, and the conductive expansion layer can expand after being heated or absorbing water to form an electrode contact protruding outwards from the contact window. Amino multi-walled carbon nanotubes, amino graphene quantum dots and gold nanoparticles are loaded in the graphene hydrogel. The electrode contact has the advantages that after the electrode contact is heated or absorbs water, the conductive expansion layer expands to form the electrode contact protruding out of the contact window, and the electrode contact is good in tissue affinity, capable of making better contact with nervous tissue and more excellent in performance.
Owner:BEIJING INSTITUTE OF GRAPHIC COMMUNICATION

Electrode array longevity

A method and system for protecting electrode arrays while implanted on a brain including a flexible electrode array including non-penetrating cortical surface microelectrodes, a ceramic layer covering the electrode array and a polymer layer adjacent the ceramic layer, wherein the ceramic layer and the polymer layer hermetically seal the electrode array. The ceramic layer can be configured to exhibit sufficient flexibility to allow the electrode array to be implanted using minimally invasive surgical techniques, while still hermetically sealing the electrode array from a biological environment.
Owner:PRECISION NEUROSCIENCE CORP

Acupuncture point stimulation current decision-making method and system based on integrated fingerstall electrode

The invention relates to the technical field of current intelligent decision making, in particular to an acupoint stimulation current decision making method and system based on an integrated fingerstall electrode, and the method comprises the steps: receiving a starting instruction of the integrated fingerstall electrode, enabling a fingerstall in the integrated fingerstall electrode to start collecting a current signal of an acupoint in real time to obtain an initial acupoint current signal, and carrying out the conversion through a trans-impedance amplifier, initial acupoint voltage signals are obtained, the initial acupoint voltage signals are preprocessed, and a target acupoint multi-domain composite feature set is obtained; performing model construction on the acupoint stimulation data set by using a deep learning algorithm to obtain an acupoint stimulation current decision model, and obtaining optimal stimulation current intensity, stimulation current frequency and stimulation current waveform parameters based on a target acupoint multi-domain composite feature set and a pre-constructed evaluation method, a plurality of micro electrodes in the fingerstall are set to obtain a current output fingerstall, and the current output fingerstall and a safety monitoring method are utilized to stimulate the target acupuncture point. According to the invention, intelligent decision of acupoint stimulation current can be realized.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

High Density Electrode Mapping Catheter

An integrated electrode structure can comprise a catheter shaft comprising a proximal end and a distal end, the catheter shaft defining a catheter shaft longitudinal axis. A flexible tip portion can be located adjacent to the distal end of the catheter shaft, the flexible tip portion comprising a flexible framework. A plurality of microelectrodes can be disposed on the flexible framework and can form a flexible array of microelectrodes adapted to conform to tissue. A plurality of conductive traces can be disposed on the flexible framework, each of the plurality of conductive traces can be electrically coupled with a respective one of the plurality of microelectrodes.
Owner:ST JUDE MEDICAL CARDILOGY DIV INC

Neural microelectrode for electrical stimulation combined with drug release and preparation method thereof

The invention discloses a neural microelectrode for electrical stimulation combined with drug release and a preparation method thereof.The neural microelectrode comprises a first flexible substrate layer, a drug-loaded slow-release layer, a second flexible substrate layer, a conductive layer and an insulating covering layer, and the drug-loaded slow-release layer contains chitosan microspheres embedded with drugs; the medicament comprises nerve growth factors and / or anti-inflammatory drugs, a plurality of drug release holes are distributed in the insulating covering layer, an electrode contact is arranged at one end of the conducting layer, a lead connector is electrically arranged at the other end of the conducting layer, and openings for exposing the electrode contact and the lead connector are correspondingly formed in the two ends of the insulating covering layer respectively. According to the neural microelectrode provided by the invention, the drug-loaded slow-release layer is integrated in the neural microelectrode, so that a space for storing a drug does not need to be additionally processed on the membrane layer, and the drug does not need to be additionally loaded, so that the production and processing are relatively convenient and rapid; after the neural microelectrode is implanted into a corresponding tissue in a body, the drug-loaded sustained-release layer can be gradually degraded to slowly release a medicament for repairing nervous tissues or avoiding rejection reaction in a long-acting manner.
Owner:BEIJING INSTITUTE OF GRAPHIC COMMUNICATION

Novel semiconductor test probe manufacturing process

The invention relates to the technical field of semiconductor micro-nano manufacturing, and discloses a novel semiconductor test probe manufacturing process which comprises the following steps: preparing an ionic liquid electrolyte containing a high-pressure priority adsorbent and a low-pressure priority adsorbent; a first voltage pulse is applied between the microelectrode and the conductive base, the amplitude of the first voltage pulse enables the high-voltage preferential adsorbent to preferentially adsorb on the surface of the microelectrode, and a flexible probe root and a flexible probe body are formed through deposition; then, a second voltage pulse is applied, and the amplitude of the second voltage pulse is lower than that of the first voltage pulse, so that the low-voltage preferential adsorbent preferentially adsorbs and deposits to form a superhard probe tip. The probe with the functional gradient structure is integrally manufactured by programmed voltage regulation and control in single continuous deposition, high hardness of the needle tip and high flexibility of the needle body are simultaneously realized on a single structure, the manufacturing process is remarkably simplified, and the cost is reduced.
Owner:SUZHOU MINGCE TECHNOLOGY CO LTD

Portable electrochemical impedance spectroscopy miniaturized detection device and method

The invention discloses a portable electrochemical impedance spectroscopy miniaturized detection device and method, and the device comprises microelectrode interfaces, each group of microelectrode interfaces is connected with an electrode, and is used for contacting a detected cell; the signal generation module is connected to the micro electrode interface and is used for sending a multi-frequency-point sine wave excitation signal; the ADC acquisition board is connected to the signal generation module and is used for acquiring signals; the impedance analysis module is connected to the ADC acquisition board and is used for receiving and processing the feedback signal; and the embedded processing layer is connected to the impedance analysis module and is used for carrying out secondary processing and operation on the feedback signal to obtain an analysis result. According to the invention, not only can the plane wiring area be reduced and the size of the detection device be reduced by adopting vertical stacking, but also different electrode systems can be compatible, the real-time analysis capability is realized, the use is flexible and convenient, the measurement frequency band is improved, the signal-to-noise ratio is high, and the requirement of multi-channel integration can be met.
Owner:ZHEJIANG XINCHI TECHNOLOGY CO LTD

Chip assembly and preparation method thereof

The invention relates to the technical field of biology, and provides a chip assembly and a preparation method thereof. The chip assembly comprises a substrate, a circuit layer, a culture piece and a microelectrode array. The microelectrode array is located in the culture tank of the culture piece, the culture tank can be used for containing the to-be-monitored organ, and the to-be-monitored organ can make contact with the substrate and make contact with the microelectrode array when located in the culture tank. The substrate and the microelectrode array are both flexible structural members, so that the substrate and the microelectrode array can deform. Therefore, when the organoid is in the culture tank and the organoid is in contact with the microelectrode array, the microelectrode array deforms to be matched with the appearance of the organoid, so that the organoid is in more sufficient contact with the microelectrode array, the signals, collected by the microelectrode array, of the organoid are more accurate, and the damage of the microelectrode array to the organoid can be reduced. The base is also a flexible structural member, and the microelectrode array arranged on the base can move correspondingly by deforming the base so as to adjust the position of the microelectrode array.
Owner:YONGJIANG LAB

Intelligent zinc-aluminum coating quality monitoring method and system for wind power blade bolt

The invention discloses an intelligent zinc-aluminum coating quality monitoring method and system for a wind power blade bolt, and solves the problems that internal defects of a coating cannot be found in an early stage and predictive maintenance cannot be realized in the prior art. The method comprises the following steps: acquiring multi-source monitoring data of coating internal defects, interface micro-strain and corrosion states through a terahertz imaging unit, a pre-embedded FBG sensing unit and a microelectrode array ECN acquisition unit which are integrated on an inspection robot; after carrying out local preprocessing by utilizing an edge computing gateway, synchronizing data to a digital twinborn analysis platform deployed with a coating state intelligent evaluation model so as to output a current health state grade and residual life prediction of the coating; finally, a maintenance decision suggestion is automatically generated or an equipment control instruction is triggered based on the result, closed-loop monitoring from state sensing to intelligent execution is formed, and the system comprises a corresponding hardware module and a software platform and is used for achieving the method.
Owner:SICHUAN DONGBO RAIL TECH CO LTD

Microelectrode for collecting cell electrophysiological signals and preparation method thereof

The invention discloses a microelectrode for collecting cell electrophysiological signals and a preparation method thereof.The microelectrode comprises a substrate, an electrode array, a wire array and a bonding pad array, the electrode array, the wire array and the bonding pad array are arranged on the substrate, the electrode array is distributed in a dispersed mode with a preset position as the center, and the wire array is connected with the electrode array and the bonding pad array; the electrode array comprises a first conducting layer, the wire array sequentially comprises a first conducting layer, a second conducting layer and an insulating layer, the bonding pad array sequentially comprises a first conducting layer and a second conducting layer, and the first conducting layer and the second conducting layer are made of different materials. According to the embodiment, the performance of the microelectrode array can be improved, the preparation cost is reduced, and the preparation efficiency is improved. The microelectrode can be widely applied to the technical field of microelectrodes.
Owner:SUN YAT SEN UNIV

High-channel clinical microelectrode array intelligent brain function positioning system and method

The invention discloses a high-channel clinical microelectrode array intelligent brain function positioning system and method, and belongs to the field of electronic information and the technical field of clinical disease diagnosis and treatment. The system comprises a microelectrode array implanted in the brain, a signal processing and transmission unit and a signal identification unit. The microelectrode array adopts a multi-channel design, so that neural electrophysiological signals and transmitter chemical signals in different depths and directions can be synchronously detected, and the resolution ratio of a single cell level is achieved. The signal processing and transmission unit is responsible for signal acquisition, amplification and transmission and applying electrical stimulation; and the signal identification unit carries out real-time processing on the signal through a convolutional neural network algorithm, rapidly identifies a target nucleus and realizes accurate positioning. The nerve cell discharge and transmitter release can be monitored in real time at different depths and in different directions, rapid and accurate target spot positioning can be achieved by means of an advanced intelligent algorithm, and a more reliable basis is provided for DBS surgery.
Owner:AEROSPACE INFORMATION RES INST CAS

Multi-nucleic acid probe rapid modification and multi-target detection device based on electric field regulation and control

The invention discloses a multi-nucleic acid probe rapid modification and multi-target detection device based on electric field regulation and control. An instrument main body in the device is integrated with an automatic liquid path system and a micro electrochemical workstation module, and is used for realizing programmable reagent and sample conveying and multi-channel electrochemical measurement. The detachable sensing chip is formed by bonding a microelectrode array chip and a micro-fluidic chip, and is switched through a PCB (Printed Circuit Board) to realize plug and play. According to the present invention, the positive suction-negative discharge strategy of the electric field is utilized, the preferred positive potential is applied to the target electrode to efficiently attract the probe, and the preferred negative potential is applied to the non-target electrode to inhibit the non-specific adsorption so as to achieve the spatial selective rapid fixation and the accurate density regulation and control of the multi-nucleic acid probe in the extremely short time; the device can be used for quantitatively detecting various body fluid disease markers in a plurality of urine samples at the same time in single operation, and an efficient, accurate and portable multi-marker comprehensive analysis solution is provided for early screening and instant diagnosis of tumors.
Owner:ZHEJIANG UNIV

Damage monitoring auxiliary system based on self-sensing concrete

The invention provides a damage monitoring auxiliary system based on self-sensing concrete, which relates to the technical field of concrete damage monitoring and comprises a self-sensing concrete hardware module, a data acquisition and processing module, an environment compensation and correction module, a data decoupling module and a data analysis and prediction module. According to the invention, the layout of the sensing network is optimized, a high-density microelectrode grid is pre-embedded in self-sensing concrete, the microelectrodes can not only increase signal acquisition points, but also effectively reduce the problem of signal attenuation, and at the same time, the electromagnetic suppression sub-module is matched, so that the resistance to local electromagnetic interference is enhanced, and the self-sensing performance of the sensor is improved. Even in a complex construction environment, good signal stability can still be kept, so that high-precision and high-robustness damage monitoring is realized by optimizing the layout of the sensing network, enhancing the anti-electromagnetic interference capability, establishing a temperature and humidity compensation model and combining an intelligent signal processing algorithm; therefore, the monitoring efficiency and the engineering applicability of the self-sensing concrete in a complex environment are improved.
Owner:GUANGDONG LABORATORY OF SOUTHERN OCEAN SCIENCE AND ENGINEERING (GUANGZHOU)

A method for preparing a transparent microelectrode array chip

The present application relates to the technical field of microelectrode preparation, and particularly relates to a transparent microelectrode array chip preparation method, comprising the following steps: S1. pretreating a glass substrate to improve the substrate surface cleanliness and adsorbability of the electrode film; S2. evaporating an ITO film on the surface of the pretreated glass substrate by using a magnetron sputtering process, as a transparent electrode; S3. spin-coating a photoresist on the surface of the ITO film and performing a patterning treatment, and then etching the ITO film to form a preset electrode structure by using a dry etching process, and then removing the photoresist and cleaning and drying; S4. coating an insulating layer on the surface of the substrate by using a PECVD process, patterning the insulating layer and etching by using a dry etching process to realize windowing, and then removing the photoresist and cleaning and drying; and realizing photoelectric synchronous detection. Avoiding metal residue interference: photoresist masks are used throughout the etching process to replace traditional metal hard masks.
Owner:WESTLAKE INSTITUTE FOR OPTOELECTRONICS

3D microelectrode arrays (3D meas) with multiple sensing capabilities for the investigation of electrogenic cells

A three-dimensional (3D) microelectrode array device for in vitro electrophysiological applications includes a substrate and micro vias extending from the bottom face to the top face of the substrate. A microneedle at each micro via extends from the bottom face upward beyond the top face and forms a hypodermic microneedle array on the top face. Metallic traces on the bottom face interconnect the hypodermic microneedles to form the 3D microelectrode array. A microheater is positioned on the bottom face of the substrate. Microfluidic ports may be formed at the substrate. Interdigitated electrodes may be formed at the substrate.
Owner:UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC

Cortical subarachnoid and intra ventricular brain interfaces

ActiveUS12673202B2Nerve structureSpinal subarachnoid space
The present disclosure is directed to neural interface devices and methods that accesses the subarachnoid space to enable minimally invasive modulation and recording of neural structures. Exemplary embodiments may comprise an implantable pulse generator and a microelectrode catheter. In particular embodiments, the microelectrode catheter comprises one or more stimulating and recording electrodes. Exemplary embodiments may also include methods comprising performing a lumbar puncture to access the spinal subarachnoid space and advancing microcatheter through the spinal subarachnoid space.
Owner:WILLIAM MARCH RICE UNIVERSITY +1

Jig for coating film with connecting portion

The present disclosure provides a jig for coating, characterized by comprising: a loading portion having a first loading surface and a bottom surface intersecting the first loading surface, and a plurality of positioning grooves for placing microelectrodes being provided side by side on the first loading surface, the positioning grooves penetrating through the bottom surface along a direction parallel to the first loading surface; and a cover plate cooperating with the first loading surface of the loading portion to fix the microelectrodes located in the positioning grooves, wherein the microelectrodes have an exposed portion not in contact with the loading portion and the cover plate. According to the present disclosure, a jig for coating capable of both batch coating and improving the consistency of coating can be provided.
Owner:SHENZHEN SIBIONICS CO LTD