629 results about "Microelectrode" patented technology

A catheter includes an elongate shaft, an electrode assembly, a connective stem, a coupler, a first magnetic position sensor, and a second magnetic position sensor. The electrode assembly includes microelectrodes. The connective stem includes a first connective stem member and a second connective stem member. The connective stem defines a first sensor receptacle and a second sensor receptacle in an exterior surface of the connective stem. The coupler is configured for coupling with the connective stem. The first magnetic position sensor is disposed in the first sensor receptacle and elongated along a first sensor longitudinal axis. The second magnetic position sensor disposed in the second sensor receptacle and elongated along a second sensor longitudinal axis that is not parallel to the first sensor longitudinal axis.

Flexible high-density mapping catheter tips and flexible ablation catheter tips with onboard high-density mapping electrodes are disclosed. These tips can be used for diagnosing and treating cardiac arrhythmias. The flexible, distal tips are adapted to conform to tissue and comprise a plurality of microelectrodes mounted to permit relative movement among at least some of the microelectrodes. The flexible tip portions may comprise a flexible framework forming a flexible array of microelectrodes (for example, a planar or cylindrical array) adapted to conform to tissue and constructed at least in part from nonconductive material in some embodiments. The flexible array of microelectrodes may be formed from a plurality of rows of longitudinally-aligned microelectrodes. The flexible array may further comprise, for example, a plurality of electrode-carrying arms or electrode-carrier bands. Multiple flexible frameworks may be present on a single device. A delivery adapter having an internal compression cone is also disclosed.

The invention relates to the technical field of corrosion monitoring, in particular to an intelligent pipeline corrosion monitoring and protection system which comprises a dynamic potential disturbance measurement module, a local microcell scanning module, a corrosion rate calculation module, a corrosion risk distribution analysis module and an environmental parameter compensation module. According to the invention, accurate measurement is realized, the spatial resolution is improved, and the current response change rate is calculated by measuring the reference potential of the surface of the pipeline, applying instantaneous disturbance, combining current change differential operation, dynamically tracking the corrosion process, improving the real-time response capability and arranging a microelectrode array to cover corrosion hot spots; the corrosion current density is solved by combining the electrochemical characteristics of the material, the corrosion rate is dynamically predicted, regional distribution is analyzed based on the change of the corrosion rate, the corrosion risk assessment precision is optimized, environmental factors are monitored, disturbance parameters are adjusted, interference is compensated, the monitoring accuracy under different working conditions is ensured, and data stability and protection measure optimization are guaranteed.

The present invention discloses an electrophysiological catheter having a distal microelectrode assembly, the distal microelectrode assembly having a covered ridge carrying a plurality of microelectrodes. The microelectrode assembly includes a first ridge radiating away from the longitudinal axis and a second ridge adjacent to the first ridge and radiating away from the longitudinal axis, the first ridge having a plurality of first microelectrodes disposed thereon. The second ridge has a plurality of second microelectrodes disposed thereon such that a first virtual circle intersecting one of the plurality of first microelectrodes does not intersect any of the second microelectrodes.

The invention discloses a brain-computer interface control system and method based on multi-mode fusion, and relates to the technical field of brain-computer interface control. Comprising a microelectrode array management module which is responsible for arranging a microelectrode array, collecting initial signals and monitoring electroencephalogram signal characteristics in real time; the parameter optimization module is used for dynamically adjusting sampling parameters of the microelectrode array so as to optimize signal quality; the multi-channel signal processing module is used for carrying out weighted fusion and noise suppression on a plurality of electrode channel signals; the self-calibration feedback module is used for optimizing acquisition parameters of the microelectrode array according to feedback self-calibration electrode parameters; the control instruction generation module is used for generating an instruction; and the output adjusting module is used for dynamically adjusting output. According to the invention, accurate acquisition and processing of the electroencephalogram signals are realized, so that the flexibility and accuracy of the system in real-time application are improved.

The present invention discloses an electrophysiology catheter having a distal electrode assembly having a covered ridge carrying a plurality of microelectrodes. The positions of the microelectrodes on each ridge are staggered relative to the microelectrodes on adjacent ridges to minimize the risk of electrodes on adjacent ridges touching each other during use of the catheter. The staggered electrode configuration provides a larger effective contact surface for the distal electrode assembly because the effective concentric electrode array is increased or at least doubled.

The invention discloses a micro-fluidic chip device for cell fusion and in-situ sorting. The micro-fluidic chip device comprises a PDMS (Polydimethylsiloxane) micro-fluidic chip, a PCB (Printed Circuit Board) and a patterned gold electrode micro-array layer which are sequentially arranged from top to bottom, the PDMS micro-fluidic chip is provided with a sample inlet, a sample outlet and a collection cavity, and the sample inlet, the sample outlet and the collection cavity are communicated through the experiment cavity; a plurality of independent channels and a capturing cavity connected with the independent channels are arranged in the experiment cavity, and a double-cavity capturing structure is arranged at an inlet of the capturing cavity; and an independent microelectrode matched with the double-cavity capture structure is arranged on the patterned gold electrode microarray. The independent microelectrodes on the patterned gold electrode microarray layer are matched with the double-cavity capture structure, so that cell capture, cell electrofusion and cell in-situ release can be realized in the same chip, and cells in the double-cavity capture structure can be controlled more accurately.

An apparatus includes a catheter assembly and an end effector. The catheter assembly includes an outer sheath with a distal end. The end effector is associated with a distal end of the catheter assembly. The end effector includes a panel assembly with microelectrodes for electrophysiological (EP) mapping. The microelectrodes are configured in a matrix within the panel assembly and provide multiple points of contact with the target tissue for EP mapping. The panel assembly can transition between a first contracted state and a second expanded state. The panel assembly can fit within the outer sheath in the first state. The panel assembly can expand outwardly away from a longitudinal axis defined by the catheter assembly in the second state once exposed distally relative to the distal end of the outer sheath.

The invention discloses a full-automatic filling and tail sealing method and system based on image recognition analysis, and relates to the technical field of image analysis, and the method comprises the following steps: extracting fluid dynamic control parameters and bubble group dynamic characteristic parameters; according to fluid dynamic control parameters, the annular microelectrode array is controlled to generate a directional electric field, and the liquid flowing state is regulated and controlled; ultrasonic action parameters are determined according to the bubble group dynamic characteristic parameters, and a frequency-adjustable ultrasonic generator is controlled to output ultrasonic modulation pulses; detecting the temperature distribution of the sealing area of the container, and applying differential heat sealing parameters to different temperature areas; and establishing a multi-layer perception neural network optimization controller, and optimizing a control parameter combination by taking the quality index of the filling and end-capping process as an optimization target. The filling method combining image recognition and electric field regulation and control is adopted, accurate control over the liquid flowing state is achieved, the problem that in the traditional filling process, liquid drawing and flow cutoff are not accurate is solved, and the filling precision and efficiency are improved.

An apparatus includes a catheter assembly and an end effector. The catheter assembly includes an outer sheath with a distal end. The end effector is associated with a distal end of the catheter assembly. The end effector includes a panel assembly with microelectrodes for electrophysiological (EP) mapping. The microelectrodes are configured in a matrix within the panel assembly and provide multiple points of contact with the target tissue for EP mapping. The panel assembly can transition between a first contracted state and a second expanded state. The panel assembly can fit within the outer sheath in the first state. The panel assembly can expand outwardly away from a longitudinal axis defined by the catheter assembly in the second state once exposed distally relative to the distal end of the outer sheath.

The invention provides a cognitive function in-vitro simulation method based on a microelectrode array (MEA) and brain organs and application of the cognitive function in-vitro simulation method, and belongs to the crossing field of brain organ in-vitro model construction, neural engineering, brain-like intelligence and the like. In an in-vitro environment, external signal (such as sound) information is converted into electrical stimulation input capable of being perceived by brain organs in an MEA electrical stimulation mode, so that the brain organs gradually learn and identify external signals in repeated electrical stimulation; after elution stimulation for a period of time, the reduction condition of recognition accuracy is observed, namely, the important memory and forgetting process in the cognitive function is simulated. According to the method, the electrophysiological response and the biological mechanism change of the brain organs under external electrical stimulation can be quantitatively evaluated, and a new possibility is provided for exploring the advanced cognitive function by utilizing the brain organs.

The invention relates to the technical field of material detection, in particular to a silver coating adhesive force detection method based on multi-frequency impedance imaging, which comprises the following steps: applying a dual-mode multi-frequency excitation signal to the surface of a silver coating through an attached microelectrode array, synchronously acquiring voltage-current response data, and generating a dual-mode multi-frequency impedance original data set; performing time-varying impedance phase-locked separation on the dual-mode multi-frequency impedance original data set, extracting a dynamic impedance component of a coating-matrix interface region, and reconstructing a three-dimensional sub-interface impedance distribution diagram; and outputting an adhesive force quantized value through an oscillation frequency-adhesive force conversion model according to the spatial oscillation frequency characteristics of the impedance phase in the three-dimensional sub-interface impedance distribution diagram. According to the invention, a double-phase-locked loop system is adopted to realize the time-varying component demodulation of the impedance response of the silver coating-matrix interface, the low-frequency dynamic impedance signal modulated by silver ion migration is effectively extracted, and the weak change of the interface bonding state is sensitively reflected.

The invention provides a system and method for detecting free carbon particles in transformer oil based on a microelectrode array, and the system comprises a sampling module which comprises an oil inlet pipeline and a filtering device, an oil sample is conveyed to a microelectrode array sensor module from a transformer oil tank through the oil inlet pipeline, and the filtering device is located in the oil inlet pipeline; a filter membrane is arranged in the filter device to remove impurities in the oil sample; the microelectrode array sensor module comprises a microelectrode array sensor, the microelectrode array sensor is nanoelectrodes arranged on a silicon substrate, the surface of the microelectrode array sensor is coated with graphene oxide to adsorb free carbon particles in an oil sample, and when the free carbon particles are adsorbed to the surface of the microelectrode array sensor, an adsorption signal is generated; and the signal processing unit is used for extracting the characteristic frequency and intensity of the vibration of the carbon particles in the adsorption signal, and classifying the carbon particles according to the characteristic frequency and intensity of the carbon particles. The device is compact in structure, the maintenance cost is reduced, and the operation process is simplified.

The invention discloses a multi-brain organ electron complex as well as a construction method and application thereof. The multi-brain organ electronic complex comprises a microelectrode array and a fusion organ attached to the surface of a chip electrode of the microelectrode array through a PDMS film, and the fusion organ can grow for more than or equal to 120 days through culture. The PDMS film is attached to the surface of the MEA chip electrode, so that the stability of combination of the MEA chip electrode and the organoid is remarkably enhanced, the construction efficiency of a multi-brain organoid electron complex is improved, and the continuity of neural signal detection is improved; a high-performance model platform is provided for multi-brain organ research, and the method has a wide application prospect.

The invention provides a three-dimensional flexible neural microelectrode and an array and a preparation method thereof. The three-dimensional flexible neural microelectrode comprises a cortical electrode part which comprises a first electrode site, and the first electrode site is used for recording a cortical electroencephalogram signal of a to-be-detected body when the cortical electrode part is attached to the cerebral cortical surface of the to-be-detected body; the implanted electrode part comprises a second electrode site, and the second electrode site is used for recording a single neuron discharge signal of the to-be-detected body when the implanted electrode part is implanted into the cerebral cortex of the to-be-detected body; wherein the cortical electrode part is located in an area defined by the implanted electrode part, so that when the implanted electrode part is implanted into the cerebral cortex, the relative position of the cortical electrode part and the surface of the cerebral cortex is kept fixed.

The invention relates to a preparation method of a microelectrode and an in-situ electrochemical Raman spectrum pool, the in-situ electrochemical Raman spectrum pool comprises a base, a working electrode, an auxiliary electrode, a reference electrode and an electrode fixing table, the base is provided with an electrolytic tank and a limiting groove, the electrode fixing table is installed on the base, the electrode fixing table is provided with a plurality of limiting holes, and the working electrode and the auxiliary electrode are arranged on the base. The working electrode is mounted on the limiting groove, extends out of the corresponding limiting hole of the electrolytic tank and is exposed; and the working electrode comprises an electrode base and the microelectrode prepared by the preparation method of the microelectrode. According to the in-situ electrochemical Raman spectrum cell, the current collector and the micro-electric body are packaged in the microelectrode in the hose together, so that the exposed part of the current collector of the microelectrode is positioned outside the electrolyte of the electrolytic cell, and the exposed part of the micro-electric body of the microelectrode is positioned in the electrolyte of the electrolytic cell; therefore, the interference of the current collector on a microelectrode signal is effectively avoided; and the electrolytic tank without a bottom hole is formed, so that the electrolyte in the electrolytic tank is further prevented from leaking.

The invention relates to the field of medical dynamic monitoring, in particular to a dynamic monitoring system for a spinal cord injury reconstruction process. Comprising an acquisition and fusion module, a dynamic modeling module, a function evaluation module and an adaptation control module. According to the system, nerve and muscle electrophysiological signals are collected through a wearable surface electrode and a flexible microelectrode array, timing sequence errors are corrected in combination with a calibration sample, and multi-modal signal fusion is achieved. And constructing a topological sequence and time sequence dependence structure, and extracting an incubation period, an activation gradient and response dispersion by adopting a time sequence convolutional network. And identifying function transition and abnormal compensation behaviors through a function evaluation module, and outputting a neural pathway response sequence diagram. And the sampling frequency, the feature weight and the evaluation period are dynamically adjusted based on a Bayesian optimization strategy, and self-adaptive optimization of the monitoring strategy is realized. Therefore, precise modeling and efficient tracking of the neural pathway function reconstruction process are realized.

The invention relates to the technical field of microfluidics, in particular to a high-throughput and high-efficiency cell extrusion microfluidic system and a particle introduction method. And a closed-loop control system integrating real-time cell deformation sensing, dynamic parameter decision and physical extrusion and alternating electric field cooperative application is constructed. The chip is provided with an inlet shunting device, a micro-channel and a channel structure of a microelectrode. The method comprises the steps of real-time deformation image acquisition and analysis and dynamic extrusion parameter decision and cooperative application. The invention provides a high-flux and high-efficiency cell extrusion microfluidic system and a particle introduction method, and aims to solve the problems that the drug loading efficiency and the survival rate are difficult to consider due to heterogeneity in the existing cell extrusion technology and a physical extrusion and electroporation coordinated regulation strategy is lacked, so that personalized precise treatment of cells is realized, and the cell quality is improved. The drug loading efficiency, the cell survival rate and the high throughput are obviously improved.

The invention discloses a collaborative light regulation and control decision method and system, and relates to the technical field of intelligent regulation and control of plant factory light environments, and the system comprises a plant physiology monitoring unit which is provided with a non-invasive microelectrode array and a hyperspectral imager; and the environment sensing unit is used for collecting illumination intensity, spectrum, temperature, humidity and carbon dioxide concentration data. According to the collaborative light regulation and control decision-making method and system, fusion of multi-source heterogeneous data is realized through a pulse time sequence coding mechanism, and the problem that environmental parameters and plant physiological statuses are difficult to collaboratively analyze in the prior art is solved; based on a dynamic optimization architecture of double-alliance Nash equilibrium, autonomous collaborative decision-making of spectrum parameters can be completed in a short time, and compared with a traditional preset light formula, the response speed is improved; decision effectiveness can be synchronously guaranteed on the virtual model and biological entity level, the light suppression misjudgment rate is reduced, and meanwhile the plant light energy utilization rate is stably improved.

The invention discloses a patch clamp electrophysiological data processing method and a patch clamp electrophysiological data processing system. The method comprises the following steps: acquiring ion channel current data through a patch clamp microelectrode; baseline drift removal processing is carried out on the ion channel current data through an adaptive quadratic linear fitting function to obtain baseline correction current data; performing discretization processing and high-frequency filtering processing on the baseline correction current data based on a preset sampling frequency to obtain a filtering current signal sequence; performing calculation through a false nearest neighbor method to obtain an optimal embedding dimension, performing calculation based on an average displacement method to obtain optimal delay time, and performing second phase space reconstruction through the filtering current signal sequence, the optimal embedding dimension and the optimal delay time to obtain an optimal vector set and a phase space reconstruction matrix; calculating through a singular value decomposition algorithm and a Shannon formula to obtain a principal component vector set and an information entropy corresponding to each vector, judging through a preset information entropy threshold to obtain a principal vector sequence, and reconstructing through a singular matrix to obtain electrophysiological feature data.

The invention discloses a device and a method for in-situ determination and reduction of greenhouse gas emission in a nitrogen and phosphorus removal process of an AOA process, and belongs to the field of sewage treatment and carbon neutralization. The device comprises a gas collection type continuous flow AOA reactor, an accurate aeration system, a gas collection system, a microelectrode system and the like. According to the device, a greenhouse gas in-situ monitoring system and a regulation and control system are integrated, the emission condition of greenhouse gases (CO2, CH4 and N2O) in the operation process of the AOA technology can be monitored in real time, then parameters such as dissolved oxygen and the sludge reflux ratio are automatically adjusted, the operation conditions are optimized, and emission of the greenhouse gases is effectively reduced. The method is also combined with a biological enhancement technology, and the ecological niche of the microbial community is adjusted by adding anaerobic ammonia oxidation filler, so that the nitrogen and phosphorus removal efficiency of the AOA process is further improved, and meanwhile, the generation of greenhouse gases is reduced. The device can comprehensively monitor the greenhouse gas in the AOA process, and provides technical support for greenhouse gas research in the biological sewage treatment process.

The present invention relates to a microelectrode array device and method for biological imaging comprising a well for containing a liquid medium; an optically transparent substrate; and a microelectrode array comprising multiple electrode pads. Each electrode pad comprises a conductive film having a thickness between 5 nm and 1000 nm comprising a carbon nanotube network and / or graphene. The microelectrode array further comprises at least one counter electrode and electrically conductive traces connecting the electrode pads with a voltage source and connecting the at least one counter electrode with the voltage source such that a potential difference can be provided between the electrode pads and the counter electrode.

The invention discloses a microelectrode structure and a manufacturing method thereof and a sensor, the microelectrode structure comprises a flexible substrate and a microelectrode system arranged on the surface of the flexible substrate, the microelectrode system comprises a counter electrode, a working electrode and a reference electrode, and electrode units are horizontally laid on the upper surface and the lower surface of the flexible substrate. The electrode units on the upper surface and the lower surface of the flexible substrate respectively comprise at least one of a counter electrode, a working electrode and a reference electrode, the electrode units on the upper surface of the flexible substrate form a first microelectrode system, and the electrode units on the lower surface of the flexible substrate form a second microelectrode system; or the electrode units on the upper surface and the lower surface of the flexible substrate jointly form a third microelectrode system. The electrodes are manufactured on the front side and the back side of the flexible substrate to form one or two microelectrode systems, the area of the microelectrodes is maximized on the limited surface of the substrate, and the detection precision is improved; double-channel double-substance monitoring, double-channel single-substance monitoring or single-channel single-substance monitoring can be achieved, and functional diversity is achieved.

The invention provides an ionizing pressure sensor preparation method, a pressure sensor, a pressure sensing glove and a monitoring system, and relates to the technical field of flexible sensors, and the method comprises the following steps: S1, preparing a microstructure electrode by using degradable elastic polyester particles (BEP particles) and PLA particles as raw materials through a method of combining electrostatic spinning and electrostatic spraying; s2, preparing an ionic dielectric layer by using degradable elastic polyester particles and ionic liquid; s3, performing face-to-face assembly on the microelectrode and the ionic dielectric layer to obtain an ionization pressure sensor (NIPS); the nanofiber membrane-based flexible pressure sensor which is low in cost, easy to batch, green and degradable is prepared, meanwhile, the device is combined with a rehabilitation glove, the flexible design enables the pressure sensor to be better attached to the hand, and the wearing comfort and the accurate sensing of hand actions are improved.

The invention relates to the technical field of bioengineering, in particular to a manufacturing method of a flexible suspended microelectrode array device, which comprises the following steps of: manufacturing a device frame with a culture tank, printing a suspended ordered carrier fiber array above the culture tank through a suspended melting electrospinning process, and carrying out metal layer patterning sputtering on an electrode on carrier fiber to obtain the flexible suspended microelectrode array device. Then forming a patterned insulating layer on the surface of the metal layer by using an electrostatic spraying mode, and finally integrating an electrostatic spinning ordered fiber scaffold as a cell culture scaffold. The prepared suspended and flexible microelectrode array device can ensure the attachment of the electrode and the cell for a long time in the cell in-vitro culture process, and realizes the long-term detection of a field potential signal. The manufacturing method does not need sacrifice materials, the preparation process is simple and efficient, the cost is reduced, and wide application prospects are achieved.

The invention discloses a micro-matrix electrode for biological tissue electric signal mapping, and belongs to the technical field of bioelectrophysiological detection.The micro-matrix electrode comprises a substrate, a matrix micro-needle, a plurality of bonding pads and a plurality of wires, the matrix micro-needle is arranged on the end face of the operation end of the substrate, and the bonding pads are symmetrically arranged on the upper surface and the lower surface of the substrate respectively; the matrix microneedle is composed of a plurality of microneedles which are arranged according to a 4 * 4 square matrix, and each microneedle is connected with the corresponding bonding pad through a wire. The embodiment of the invention also discloses a preparation method of the micro-matrix electrode. The preparation method comprises the following steps: S1, processing the conversion connection part and the operation part; s2, preparing a matrix microneedle; s3, preparing a bonding pad; s4, aerosol is sprayed and deposited to obtain a plurality of wires, one ends of every two wires are connected with the corresponding microneedles, the other ends of every two wires are connected with the corresponding bonding pads, and then the micro-matrix electrode is obtained.

The invention discloses a bone organ chip loaded with a microelectrode array and a use method, and relates to the technical field of organ chips, the bone organ chip is made of a polydimethylsiloxane material, and the bone organ chip comprises a three-layer structure: a top layer, a middle layer and a bottom layer; the middle layer comprises two blood vessel micro-channels, two osteoblast micro-channels and a neuron micro-channel, the channels are separated through columns and micro-columns, and cell interaction in a bone micro-environment is simulated; a microelectrode array is arranged on the top layer and is used for monitoring electrical activity of neurons in real time; the bottom layer is provided with a pneumatic valve which can control opening and closing of the micro-channel. According to the invention, nerve and blood vessel channels are introduced, a nerve-blood vessel-immunoregulation bone microenvironment is constructed, physiological processes such as osteogenesis-blood vessel formation coupling and the like are embodied, intervals of different sizes can enhance intercellular crosstalk and allow blood vessels and neuron axons to selectively pass through, so that the chip can simulate a complex microenvironment of bone tissues, and the microenvironment of the bone tissues can be simulated; and an efficient and accurate in-vitro model is provided for bone disease mechanism research and drug development.

The invention relates to an implantable gamma-aminobutyric acid detection system, which belongs to the technical field of neurochemical detection and comprises an implantable microelectrode array device, a signal detection circuit module, a first wireless data transceiving module, a second wireless data transceiving module and a detection terminal. The invention also provides a dynamic real-time calibration method. The method comprises the following steps: implanting the implanted microelectrode array device into an animal body; measuring two paths of electrochemical impedance data between the working electrode and the reference electrode and between the calibration electrode and the reference electrode by using a signal detection circuit module; calculating an estimated value of the concentration of gamma-aminobutyric acid by adopting an improved Randles circuit model; estimating the measurement error of the gamma-aminobutyric acid concentration by using an artificial neural network; and calibrating the measurement error to obtain a gamma-aminobutyric acid concentration detection value.

A method and system for decoding speech based on recorded brain signals is provided. The method can include receiving recorded brain signals via a microelectrode array. The method can include extracting one or more features from the recorded brain signals. The method can include converting the one or more extracted features into one or more feature embeddings. The method can include transforming, by one or more encoders, the one or more feature embeddings. The method can include predicting, by one or more decoders, phonemes based on the one or more transformed feature embeddings. The method can include predicting speech based on the predicted phonemes.

The invention relates to the technical field of neural microelectrodes, and provides a stent electrode which comprises a deformation part, the deformation part is provided with wire bodies which are interwoven to form a net structure, an electrode is arranged at the interwoven position of the net structure, and the electrode is communicated with a conductor. And the conductor is laid on the deformation part and is led out of the deformation part from the edge of the deformation part. The invention further provides a preparation method of the stent electrode. The electrodes are arranged on the deformation part, the limitation of the number of the electrodes can be broken through, a higher channel can be formed, the conductors used for leading out electrode signals are arranged on the deformation part, conductor wiring is simple, and mutual entanglement of wires can be avoided; the electrode bracket is manufactured by adopting an integrated preparation process, so that the electrode and the conductor can be integrated, and the sizes of the electrode and the conductor can be adjusted according to specific clinical requirements.