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Combinatorial Electrochemical Synthesis

a technology of electrochemical synthesis and compound, applied in the field of compound compound compound compound compound, can solve the problems of large investment in new drug development, time-consuming and laborious, step-by-step preparation of individual potentially bioactive agents,

Inactive Publication Date: 2002-01-24
THERASENSE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

0007] The present invention provides an electronic device and method for the combinatorial synthesis of biopolymers, alloys, and non-stochiometric inorganic compounds. The device includes an array of selectively addressable microelecrodes which preferably includes on its surface a conductive matrix, which may be a redox polymer or hydrogel. The matrix further comprises functional reactive groups, such as amines, aldehydes, carboxyllic acids, active esters, and the like, useful for the sequential addition of monomeric units to form polymeric compounds. For example, in one embodiment of the invention, the array includes amines in the matrix, to which nucleotides or oligonucleotides may be sequentially added by chemical reaction.
0008] In the method of the invention, a potential sufficient to induc...

Problems solved by technology

Conventional synthetic methods are time consuming and the step-by-step preparation of individual potentially bioactive agents consumes the largest fraction of the capital invested in the development of new drugs.
The syntheses involved small but still significant amounts of expensive reactants, typically more than a billion molecules in each reaction in each pixel.

Method used

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Embodiment Construction

[0015] Microelectrode ArrayThe electronic device of the invention includes an array of selectively addressable microelectrodes. A matrix comprising at least carbon (C) and hydrogen (H), and preferably capable of conducting electrons or holes, and also of conducting ions, is disposed on a surface of the electrodes. The conductive matrix is disposed on the microelectrode with a thickness greater than 3 nanometers, and preferably in the range of 3 nanometers to 20 microns, most preferably with a thickness of 5 or more nanometers. Most preferably, the matrix comprises a redox polymer or redox hydrogel, having a molecular weight of more than 10.sup.4 daltons. Most preferably, the redox polymer or hydrogel comprises a fast redox couple, such as complexes of transition metals such as osmium, ruthenium, iron, copper, and cobalt.

[0016] The matrix is modified to include functional reactive groups, such as amines, aldehydes, carboxyllic acids, active esters, and the like.

[0017] The arrays of e...

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Abstract

<heading lvl="0">Abstract of Disclosure< / heading> An array of selectively addressible microelectrodes for combinatorial synthesis of complex polymers or alloys.

Description

Cross Reference to Related Applications[0001] This application is a continuation application of PCT Application No. PCT / US99 / 14459 A1, which claims priority to Provisional Patent Application Serial No. 60 / 090,520, which applications are hereby incorporated for all purposes.Background of Invention[0002] Field of the Invention The present invention is generally related to the combinatorial syntheses of compounds, particularly of biological compounds and metal alloys, on microelectrode arrays. The invention relates in particular to the combinatorial syntheses of oligonucleotides, peptides and biologically active compounds on microelectrode arrays under electrochemical control.[0003] Background of the Invention: The simultaneous synthesis of massive numbers of different oligonucleotides, peptides, and biologically active compounds has applications in the identification of new drugs, in the mapping of genes, and in testing for interactions between biological molecules. Arrays of differen...

Claims

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Application Information

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IPC IPC(8): B01J19/00C07B61/00C07H21/00C40B40/18C40B60/14
CPCB01J19/0046B01J2219/00353B01J2219/00389B01J2219/00605B01J2219/00612B01J2219/00621B01J2219/00626B01J2219/00628B01J2219/00637B01J2219/00653B01J2219/00659B01J2219/00689B01J2219/00713B01J2219/00745B01J2219/00752C07B2200/01C07H21/00C40B40/18C40B60/14C40B80/00
Inventor HELLER , ADAMCARUANA , DAREN J.
Owner THERASENSE
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