194 results about "Peripheral neuron" patented technology

The invention relates to the technical field of artificial intelligence assisted medical rehabilitation, in particular to a peripheral nerve injury personalized rehabilitation system and method based on a multi-modal large model, and the method comprises the steps: a feature fusion module employs space-time attention to fuse multi-modal time series data, and constructs an evaluation map; the personalized generation module is combined with historical data and reinforcement learning to generate a scheme containing virtual scene parameters; the interaction feedback module collects data through mixed reality and calculates action deviation; and the adaptive adjustment module adopts a meta-learning optimization model and a distributed iterative output scheme. According to the method, the cross-modal association precision of the motion features and the mechanical parameters is improved, dynamic matching of the training scene and the motion ability of the user is achieved, the virtual environment and the mechanical feedback threshold are optimized by dynamically adjusting the rehabilitation scheme parameters, the scheme optimization period is shortened based on an online iterative optimization mechanism, and the training efficiency is improved. The core defects of personalized adaptation lagging and low utilization efficiency of multi-modal data are overcome.

The invention belongs to the technical field of medical electronic equipment, and discloses a control system for alternative electrical stimulation of idiopathic tremor, and the system comprises a signal collection module which is used for obtaining tremor motion data of a patient in real time; the signal processing module is used for analyzing tremor frequency, amplitude and phase characteristics; the dynamic parameter generation module is used for generating an alternate stimulation mode according to the tremor characteristics; and the electrode array module comprises at least two stimulating electrodes and a reference electrode. The invention provides a non-invasive and dynamically optimized alternate electrical stimulation control system which is used for inhibiting hand tremor of an idiopathic tremor patient, regulation and control of a tremor network can be enhanced by alternately stimulating different peripheral nerves, the curative effect can be improved through closed-loop feedback optimization parameters, long-acting and safe tremor inhibition is achieved, and the treatment effect is improved. The problems of insufficient curative effect, nerve adaptability, surgical risk and the like in the prior art are solved.

Disclosed herein are systems, devices, and methods for stimulating nerves, including electrically stimulating peripheral nerve(s) to treat various diseases and disorders, as well as systems and methods for applying stimulation waveforms for improving the therapeutic benefit, outcomes, and / or experience relating to the same. Some systems and methods generate a biphasic stimulation waveform that includes a plurality of pulses with alternating leading phases. Some systems and methods vary one or more parameters of the stimulation waveform to correlate with a characteristic of the user. Example characteristic of the user include a phase of a tremor exhibited by the user and a respiratory cycle of the user. For some systems and methods, the stimulation waveform includes a plurality of burst with each burst ramping up in amplitude. For some systems and methods, the stimulation waveform is delivered during a time period that includes an on-cycle portion and an off-cycle portion with the stimulation waveform only being delivered during the on-cycle portion of the time period.

According to the flexible array type external field program control nerve stimulation device, the preparation method and the application thereof, the flexible array type external field program control nerve stimulation device comprises a flexible substrate layer and a stimulation response fiber array layer, and the stimulation response fiber array layer is prepared from a functional material capable of converting external field energy such as ultrasound, magnetism and light into electric energy; the flexible substrate layer with high flexibility is adopted, so that the flexible substrate layer can be matched with the surface of a nerve target tissue in a conformal manner; the stimulation response fiber array layer integrated on the flexible substrate layer in an array arrangement mode can meet the stimulation spatial resolution of neuron and even sub-neuron precision, has the characteristics of excellent flexibility, biocompatibility, passivity and wireless performance, can provide nerve electrical stimulation signals with high spatial resolution, and can be applied to the field of nerve electrical stimulation. The high-resolution nerve electrical stimulation device can be in conformal fit with the irregular surface of nerve soft tissue, and is suitable for high-resolution nerve electrical stimulation of different parts such as eyes, the brain and peripheral nerves.

A peripheral nerve stimulator to stimulate a peripheral nerve to treat essential tremor and other movement disorders, as well as overactive bladder, cardiac dysfunction and neurotransmitter dysfunction is provided. The peripheral nerve stimulator can be a noninvasive surface stimulator to provide multi-modal optimized therapy. Stimulation can be vibrational, electromechanical, thermal, radiant, electrical, magnetic, electromagnetic, light, mechanical, chemical, thermal, ultrasonic, radiofrequency (RF), acoustic, infrared, ultraviolet, x-ray, and / or microwave. Stimulation can be delivered using an open loop system and / or a closed loop system with feedback. Stimulation can be to one site or multiple sites.

Systems, devices and methods are disclosed for the treatment of injured peripheral nerves or other tissue using electrical stimulation. The systems can be used either in intraoperative or peri-operative settings and incorporate the use of either a plurality of monopolar electrodes with a patch used as return or a plurality of bipolar electrodes such as a cuff. The systems can provide hands-free delivery of electrical stimulation therapy over a predetermined set of time.

A peripheral nerve device can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The device may contain an interface separated, partially separated, or connected to a housing, and which may interact with the user. The interface may connect to the housing and be disposable after use for a period of time.

A system and method for locating and guiding a peripheral nerve evaluation (PNE) lead. The system comprising an X-ray system to capture images of the patient. The images are processed by the system and are provided to a user to utilize an augmented reality (AR) system for inserting a needle for placing leads for the PNE procedure.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor. Parkinson tremor, and other forms of tremor. For example, a stimulation device can record and transmit data to a cloud-based server in certain aspects.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. In one aspect, the stimulation algorithm is designed to optimize the therapy. The algorithm may be a learning algorithm to tailor the stimulation over time to adjust in real-time to a user's tremor user-defined needs. Stimulation can be delivered using open and / or closed loop systems.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor. Parkinson tremor, and other forms of tremor. Stimulation of nerves using machine learning algorithms are provided in certain aspects.

Systems, devices, and methods for stimulating peripheral nerves in the fingers or hand to treat tremor are described. For example, a wearable ring device for delivering electrical stimulation to sensory nerves in a patient's finger can include an annular ring having a plurality of electrodes and a detachable unit having a power source and a pulse generator.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate at least one of tremor feedback, external data, predictive adaptation, or long-term monitoring data. The device may be configured as a wrist worn device to stimulate three nerves to provide tremor reduction.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

The present disclosure relates to compositions for increasing acetylated alpha-tubulin levels in peripheral neuronal cells. The present disclosure also relates to the use of tubulin deacetylase inhibitors, or activators of tubulin acetylation for increasing acetylated tubulin levels in the cells. The present disclosure also relates to methods for assessing risk of developing peripheral neuropathy by assessing the levels of acetylated alpha-tubulin. The present disclosure further relates to methods for treating a subject suffering from a peripheral neuropathy using the compositions described herein.

The invention relates to the technical field of biomedical materials, in particular to a high-conductivity peripheral nerve socketed pipe and a preparation method thereof. The nerve socketed pipe is a hollow cylindrical socketed pipe made of a material containing poly (octylene-citrate-co-octanol) POCO, and a regeneration promoting material is loaded in the hollow cylindrical socketed pipe; the regeneration promoting material comprises fetal calf serum and a DMEM cell culture medium. The POCO has the advantages of conductive activity, nerve regeneration induction, free radical scavenging ability, oxidation resistance, deformation resistance and the like, and has good degradability and biocompatibility, so that the nerve socketed pipe is prepared from poly (octylene-citrate-co-octanol), and the growth of axons is accelerated through electrical stimulation. Furthermore, at least one conductive monomer of pyrrole, aniline, p-phenylenediamine, o-methoxyaniline, thiophene, 3-hexylthiophene, 3-thiopheneacetic acid and 3, 4-ethylenedioxythiophene is adopted for modifying the POCO hollow cylindrical socketed pipe through in-situ oxidative polymerization, and the performance of the POCO hollow cylindrical socketed pipe serving as the neural restoration material is further improved.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulator may be inductively charged in certain aspects. The stimulation device can be configured to be worn on the wrist of a user.

The application provides a peripheral nerve precise regulation method and system based on a multi-channel flexible electrode, and is applied to the technical field of data processing. The physiological parameter information of a target user is processed based on a target peripheral nerve stimulation model to generate a muscle contraction characteristic comprehensive index, wherein the muscle contraction characteristic comprehensive index includes a muscle contraction amplitude, a contraction frequency, and the contraction frequency is clearly distinguished according to fast muscle, slow muscle and different movement modes. The training purpose information and the muscle contraction characteristic comprehensive index of the target user are processed based on the target peripheral nerve stimulation model to generate a preliminarily adjusted muscle contraction signal. The preliminarily adjusted muscle contraction signal is processed based on the physiological characteristic information of a target organ to generate a secondarily adjusted muscle contraction signal. The secondarily adjusted muscle contraction signal is processed based on the movement intensity interval information of the target organ to generate a target peripheral nerve stimulation signal.

Embodiments of the disclosure provide a device. The device comprises a body and a hook coupled to the body. The hook can be configured to receive a collar. The device comprises an arm coupled to the body. The collar can be positioned between the arm and the hook. The device comprises an actuator coupled with the hook. When the collar is in an open configuration, the collar can be positioned between and engaged by the hook and the arm. The collar can surround a peripheral nerve. From the open configuration, the actuator can be configured to pull the hook towards the body thereby forcing the collar to close around the peripheral nerve and force the collar into a closed configuration.

Systems and methods of applying electrical stimulation to achieve sustained relief of chronic pain that comprise a coiled wire percutaneous lead configured for insertion into a portion of a body that is proximal to a region of pain and an electrode formed integrally on the coiled wire percutaneous lead, wherein the electrode is configured to be positioned inside the body and at a therapeutically effective distance from a portion of at least one peripheral nerve that innervates the region of pain. The systems and method may also include an electrical stimulation device operatively coupled to the lead to apply electrical stimulation through the at least one electrode to at least one peripheral nerve that innervates the region of pain, to activate target peripheral nerve fibers while preventing activation of non-target peripheral nerve fibers and avoiding changing or blocking neural activity in off-target peripheral nerve fibers in the at least one peripheral nerve to create comfortable sensations in the region of pain and produce pain relief by modulating central nervous system plasticity associated with the pain.

The present disclosure relates to the use of therapeutic ultrasound to non-invasively stimulate multiple peripheral nerve pathways that modulate energy homeostasis. An embodiment of the disclosed neuromodulation techniques includes neuromodulation techniques to treat a patient with a metabolic disorder. Certain embodiments of the disclosure are discussed in the context of blood glucose regulation.

The invention provides a near-infrared chiral magnesium-based superparticle nerve photoconductive tube, a preparation method thereof and application of the near-infrared chiral magnesium-based superparticle nerve photoconductive tube in peripheral nerve regeneration, and belongs to the field of synthesis and application of medical stent materials. A chiral magnesium-based superparticle is provided; dispersing the chiral magnesium-based superparticles in an organic solvent, and adding polycaprolactone in batches to obtain a high-viscosity spinning solution; carrying out electrostatic spinning on the spinning solution, uniformly covering a roller with non-wrinkle tin foil paper, collecting the tin foil paper covered with spinning, cutting the tin foil paper into small pieces, and soaking the small pieces in absolute ethyl alcohol or a PBS (Phosphate Buffer Solution); the spinning film on the soaked small piece of tin foil paper is rolled into a chiral nerve conduit, after the chiral nerve conduit is rolled, the chiral nerve conduit is strung through a stainless steel rod and dried, plasticization of the conduit is achieved, and the near-infrared chiral magnesium-based superparticle nerve photoelectric conduit is obtained. The near-infrared chiral magnesium-based superparticle nerve photoconductive tube obtained by the invention has important significance on repair after sciatic nerve injury.

The application belongs to the technical field of bone organ preparation, and relates to a bone organ for promoting nerve growth and a construction method and application thereof. The construction method comprises the following steps: S1, immersing a hydrogel mineralization scaffold with conductive polymer induction in an EDC / NHS crosslinking agent, and sterilizing and crosslinking; S2, immersing the crosslinked product in a culture medium and culturing, inoculating bone organ seed cells, and replacing the culture medium with a complete culture medium for adaptive culture; and S3, transferring to an osteogenic induction culture medium for osteogenic induction, so as to obtain the bone organ for promoting nerve growth. Compared with the prior art, the bone organ constructed by the application has good biological activity, osteogenic activity and bone conduction, can effectively promote the growth of peripheral nerves, provides a reliable in-vitro model for bone-nerve interaction research, and provides a new technical path and theoretical basis for bone-nerve integrated regeneration and repair.

Disclosed in the present invention are a peripheral nerve catheter and a preparation method therefor. The peripheral nerve catheter comprises: an outer sheath, which is a hollow braided tube that has micron-sized pores and is non-wound; at least one inner core tube, which is placed in the outer sheath and is coaxially arranged with the outer sheath, each inner core tube being a hollow fiber tube that has micro / nano-sized pores and is non-wound; and filling gel, which is filled between the outer sheath and the inner core tube to fix the inner core tube. The bionic nerve catheter having a structure composed of the inner core and the outer sheath according to the present invention can achieve effective nerve regeneration, the inner core tube, which axially runs through the outer sheath, has a topological structure that is conducive to the adhesion and directional growth of nerve cells, and also has a micro / nano-sized pore structure that is conducive to the penetration of nutrients for growth and the formation of nerve connections and neurovascular network. In addition, the filling and curing of the filling gel effectively prevents the infection of damaged tissues, and is conducive to the penetration of nutrients and the transfer of cellular metabolic waste.

A peripheral nerve stimulator to stimulate a peripheral nerve to treat essential tremor and other movement disorders, as well as overactive bladder, cardiac dysfunction and neurotransmitter dysfunction is provided. The peripheral nerve stimulator can be a noninvasive surface stimulator to provide multi-modal optimized therapy. Stimulation can be vibrational, electromechanical, thermal, radiant, electrical, magnetic, electromagnetic, light, mechanical, chemical, thermal, ultrasonic, radiofrequency (RF), acoustic, infrared, ultraviolet, x-ray, and / or microwave. Stimulation can be delivered using an open loop system and / or a closed loop system with feedback. Stimulation can be to one site or multiple sites.

The invention discloses a transdermal patch containing lidocaine, the transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises active ingredients lidocaine, an acrylic acid pressure-sensitive adhesive and a penetration enhancer, the weight content of the lidocaine is 21-33%, the weight content of the acrylic acid pressure-sensitive adhesive is 45-75%, the weight content of the penetration enhancer is 1-10%, and the weight content of the penetration enhancer is 1-10%. The weight content of the penetration enhancer is 3%-25%. The transdermal patch disclosed by the invention is simple in prescription and process, good in drug permeability and colloid application performance and high in stability, can be continuously used for a long time without causing skin irritation, and is suitable for treating peripheral nerve related pains, especially patients requiring long-term administration such as post-herpes zoster neuralgia.

The application provides a self-coiled flexible peripheral nerve electrode and a preparation method and application thereof, and the preparation method comprises the following steps: preparing a double-layer flexible liquid metal electrode with an exposed site; stretching the double-layer flexible liquid metal electrode, and then fixing two ends of the double-layer flexible liquid metal electrode to obtain a stretched electrode; coating a polymer prepolymer reaction solution on a surface of the stretched electrode which is opposite to the exposed site, and curing the polymer prepolymer reaction solution to form a fixing layer, so as to obtain a three-layer composite electrode; under the condition that the two ends are fixed, the fixing layer in the three-layer composite electrode faces downward, the fixing of one end of the three-layer composite electrode is released, and the three-layer composite electrode is self-coiled. The self-coiled flexible peripheral nerve electrode prepared by the preparation method of the self-coiled flexible peripheral nerve electrode has high conductivity, can realize self-coiling of the electrode, improves the detection quality and long-term stability of nerve signals, and avoids mechanical damage of nerve tissue caused by electrode implantation.

The present invention provides a polyamino acid hydrogel and a preparation method thereof, as well as a hydrogel catheter and a preparation method thereof. The present invention prepares chiral lysine N-carboxyl anhydride and L-glutamic acid N-carboxyl anhydride respectively, and then uses them as raw materials, initiates with double-terminal amino polyethylene glycol NH2-PEG-NH2, and prepares double-terminal polylysine polymers shown in formula (I'-1) / formula (I'-2) and double-terminal polyglutamic acid polymers of formula (II'), respectively. Afterwards, double-terminal polylysine polymer solutions and double-terminal polyglutamic acid polymer solutions are prepared respectively, and the two solutions are mixed in a catheter consisting of an electrospinning membrane, and quickly gelled to form a hydrogel catheter. The above-mentioned hydrogel is filled inside, which has a supporting effect on the catheter, avoids the problem that the hollow catheter is easy to collapse, and at the same time simulates the natural nerve cell extracellular matrix by the hydrogel itself and its degradation products, thereby achieving a better peripheral nerve defect repair effect.

Embodiments described herein relate to restorative solutions for segmental peripheral nerve (PN) defects using allografted PNs for stimulating PN repair. More specifically, embodiments described herein provide for localized immunosuppression (LIS) surrounding PN allografts as an alternative to systemically suppressing a patient's entire immune system. Methods include localized release of immunosuppressive (ISV) agents are contemplated in one embodiment. Methods also include localized application of immunosuppressive (ISV) regulatory T-cells (Tregs) and / or mesenchymal stomal cells in other embodiments. Hydrogel carrier materials are also described herein.

The present invention relates to the field of nerve repair technology, and discloses a hydrogen and magnesium ion pump catheter with a Janus structure for peripheral nerve defect repair and a preparation method thereof. The pump catheter is composed of a hydrophilic inner layer, a hydrophobic outer layer, and a reservoir middle layer. The hydrophilic inner layer and the hydrophobic outer layer are made of degradable polymer materials, and the reservoir middle layer is made of a mixture of one or more of polylactic acid, polyglycolide, or polylactic-glycolic acid and a magnesium-based material. The pump catheter has a Janus structure, the hydrophilic inner layer provides biophysical clues, improves the cell compatibility of the catheter, and promotes the adhesion and migration of nerve cells. The hydrophobic outer layer blocks the adhesion and invasion of unfavorable cells such as fibroblasts to the damaged area. The magnesium ion and hydrogen reservoir middle layer can continuously release hydrogen and magnesium ions, exerting biological effects, improving the nerve regeneration microenvironment, and improving the effect of the stent in repairing nerve damage.