260 results about "Peripheral neuron" patented technology

The invention relates to the technical field of artificial intelligence assisted medical rehabilitation, in particular to a peripheral nerve injury personalized rehabilitation system and method based on a multi-modal large model, and the method comprises the steps: a feature fusion module employs space-time attention to fuse multi-modal time series data, and constructs an evaluation map; the personalized generation module is combined with historical data and reinforcement learning to generate a scheme containing virtual scene parameters; the interaction feedback module collects data through mixed reality and calculates action deviation; and the adaptive adjustment module adopts a meta-learning optimization model and a distributed iterative output scheme. According to the method, the cross-modal association precision of the motion features and the mechanical parameters is improved, dynamic matching of the training scene and the motion ability of the user is achieved, the virtual environment and the mechanical feedback threshold are optimized by dynamically adjusting the rehabilitation scheme parameters, the scheme optimization period is shortened based on an online iterative optimization mechanism, and the training efficiency is improved. The core defects of personalized adaptation lagging and low utilization efficiency of multi-modal data are overcome.

Systems, devices, and methods for electrically stimulating peripheral nerve(s) to treat various disorders are disclosed, as well as signal processing systems and methods for enhancing diagnostic and therapeutic protocols relating to the same. Personalized therapy based on algorithms and aggregated data are also provided.

The present invention relates to a novel association or combination of active ingredients useful in the prevention and repair of neuronal damage, both centrally and peripherally. In greater detail, the present invention relates to an association or combination of i) an extract of Gastrodia elata and ii) at least one ingredient selected from the group comprising or, alternatively, consisting of citicoline, L-acetylcarnitine and, preferably, at least one vitamin of group D, and / or mixtures thereof, and / or at least one vitamin of group B, and / or mixtures thereof. Furthermore, the invention also relates to the pharmaceutical compositions and / or compositions for medical devices (Regulation (EU) 2017 / 745) and / or nutraceutical and / or food compositions comprising that association and to their use in therapy, in particular in the protection of the functionality of the nervous system and in the prevention and / or treatment of central and peripheral neuropathies.

The invention belongs to the technical field of medical electronic equipment, and discloses a control system for alternative electrical stimulation of idiopathic tremor, and the system comprises a signal collection module which is used for obtaining tremor motion data of a patient in real time; the signal processing module is used for analyzing tremor frequency, amplitude and phase characteristics; the dynamic parameter generation module is used for generating an alternate stimulation mode according to the tremor characteristics; and the electrode array module comprises at least two stimulating electrodes and a reference electrode. The invention provides a non-invasive and dynamically optimized alternate electrical stimulation control system which is used for inhibiting hand tremor of an idiopathic tremor patient, regulation and control of a tremor network can be enhanced by alternately stimulating different peripheral nerves, the curative effect can be improved through closed-loop feedback optimization parameters, long-acting and safe tremor inhibition is achieved, and the treatment effect is improved. The problems of insufficient curative effect, nerve adaptability, surgical risk and the like in the prior art are solved.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator. Stimulation can be electrical, mechanical, or chemical. Stimulation can be delivered using either an open loop system or a closed loop system with feedback.

Disclosed herein are systems, devices, and methods for stimulating nerves, including electrically stimulating peripheral nerve(s) to treat various diseases and disorders, as well as systems and methods for applying stimulation waveforms for improving the therapeutic benefit, outcomes, and / or experience relating to the same. Some systems and methods generate a biphasic stimulation waveform that includes a plurality of pulses with alternating leading phases. Some systems and methods vary one or more parameters of the stimulation waveform to correlate with a characteristic of the user. Example characteristic of the user include a phase of a tremor exhibited by the user and a respiratory cycle of the user. For some systems and methods, the stimulation waveform includes a plurality of burst with each burst ramping up in amplitude. For some systems and methods, the stimulation waveform is delivered during a time period that includes an on-cycle portion and an off-cycle portion with the stimulation waveform only being delivered during the on-cycle portion of the time period.

Systems, devices and methods are disclosed for the treatment of injured peripheral nerves or other tissue using electrical stimulation. The systems can be used either in intraoperative or peri-operative settings and incorporate the use of either a plurality of monopolar electrodes with a patch used as return or a plurality of bipolar electrodes such as a cuff. The systems can provide hands-free delivery of electrical stimulation therapy over a predetermined set of time.

According to the flexible array type external field program control nerve stimulation device, the preparation method and the application thereof, the flexible array type external field program control nerve stimulation device comprises a flexible substrate layer and a stimulation response fiber array layer, and the stimulation response fiber array layer is prepared from a functional material capable of converting external field energy such as ultrasound, magnetism and light into electric energy; the flexible substrate layer with high flexibility is adopted, so that the flexible substrate layer can be matched with the surface of a nerve target tissue in a conformal manner; the stimulation response fiber array layer integrated on the flexible substrate layer in an array arrangement mode can meet the stimulation spatial resolution of neuron and even sub-neuron precision, has the characteristics of excellent flexibility, biocompatibility, passivity and wireless performance, can provide nerve electrical stimulation signals with high spatial resolution, and can be applied to the field of nerve electrical stimulation. The high-resolution nerve electrical stimulation device can be in conformal fit with the irregular surface of nerve soft tissue, and is suitable for high-resolution nerve electrical stimulation of different parts such as eyes, the brain and peripheral nerves.

A peripheral nerve stimulator to stimulate a peripheral nerve to treat essential tremor and other movement disorders, as well as overactive bladder, cardiac dysfunction and neurotransmitter dysfunction is provided. The peripheral nerve stimulator can be a noninvasive surface stimulator to provide multi-modal optimized therapy. Stimulation can be vibrational, electromechanical, thermal, radiant, electrical, magnetic, electromagnetic, light, mechanical, chemical, thermal, ultrasonic, radiofrequency (RF), acoustic, infrared, ultraviolet, x-ray, and / or microwave. Stimulation can be delivered using an open loop system and / or a closed loop system with feedback. Stimulation can be to one site or multiple sites.

Systems, devices, and methods for electrically stimulating peripheral nerve(s) to treat various disorders are disclosed, as well as signal processing systems and methods for enhancing diagnostic and therapeutic protocols relating to the same.

Systems, devices and methods are disclosed for the treatment of injured peripheral nerves or other tissue using electrical stimulation. The systems can be used either in intraoperative or peri-operative settings and incorporate the use of either a plurality of monopolar electrodes with a patch used as return or a plurality of bipolar electrodes such as a cuff. The systems can provide hands-free delivery of electrical stimulation therapy over a predetermined set of time.

Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a light source and a speaker. A visual neural stimulation system provides, via the light source, visual stimulation having a first value of a first parameter. An auditory neural stimulation system provides, via the speaker, audio stimulation having a second value of the second parameter. A stimuli orchestration component selects, for a first time interval, one of the visual stimulation or the audio stimulation to vary based on a policy, selects, for the first time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy, and provides causes the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation.

A peripheral nerve device can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The device may contain an interface separated, partially separated, or connected to a housing, and which may interact with the user. The interface may connect to the housing and be disposable after use for a period of time.

A system and method for locating and guiding a peripheral nerve evaluation (PNE) lead. The system comprising an X-ray system to capture images of the patient. The images are processed by the system and are provided to a user to utilize an augmented reality (AR) system for inserting a needle for placing leads for the PNE procedure.

The novel flexible electrodes disclosed herein utilize the low bending stiffness of electrospun nanofiber mats to achieve the material properties required for surgical implantation and sustained bidirectional communication with peripheral nerves without compromising electronic functionality. According to certain embodiments disclosed herein, implantable neural electrode probes are provided which comprise a polymeric substrate having proximal and distal ends, an electrode interface at the proximal end of the substrate; at least one neural contact at the distal end of the substrate; and electrically conductive traces formed on the fibrous substrate providing electrical communication between the at least one neural contact and the electrode interface, wherein the substrate comprises a nonwoven mass of polymeric nanofibers.

The invention relates to the technical field of plant extracts, and provides a plant extract composition with synergistic hypoglycemic activity and application thereof, and the plant extract composition comprises a mulberry leaf extract, a white kidney bean extract and bitter gourd powder in a mass ratio of 8: (1-24): (1-64). By optimizing the mass ratio of the mulberry leaf extract, the white kidney bean extract and the bitter gourd powder, the blood sugar reducing effect of the plant extract taking the mulberry leaf extract, the white kidney bean extract and the bitter gourd powder as main raw materials is remarkably superior to that of a plant extract in the prior art. Meanwhile, the plant extract composition also has the effects of synergistically reducing the number of neutrophils around nerves, improving peripheral neuroinflammation, synergistically enhancing the fluorescence intensity of the peripheral nerves, improving peripheral nerve injury and inhibiting the enzymatic activity of a bacterium source dipeptidyl peptidase-4.

The invention provides a peripheral nerve precise regulation and control method and system based on a multi-channel flexible electrode, and is applied to the technical field of data processing. Physiological parameter information of a target user is processed based on a target peripheral nerve stimulation model, muscle contraction characteristic comprehensive indexes are generated, the muscle contraction characteristic comprehensive indexes comprise muscle contraction amplitude and contraction frequency, and the contraction frequency is clearly distinguished according to fast muscles, slow muscles and different motion modes; processing the training purpose information and the muscle contraction characteristic comprehensive index of the target user based on the target peripheral nerve stimulation model, and generating a preliminarily adjusted muscle contraction signal; processing the preliminarily adjusted muscle contraction signal based on the physiological feature information of the target organ to generate a secondarily adjusted muscle contraction signal; and processing the muscle contraction signal after secondary adjustment based on the motion intensity interval information of the target organ, and generating a target peripheral nerve stimulation signal.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor. Parkinson tremor, and other forms of tremor. For example, a stimulation device can record and transmit data to a cloud-based server in certain aspects.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. In one aspect, the stimulation algorithm is designed to optimize the therapy. The algorithm may be a learning algorithm to tailor the stimulation over time to adjust in real-time to a user's tremor user-defined needs. Stimulation can be delivered using open and / or closed loop systems.

The invention relates to the technical field of peripheral nerve injury suture, and particularly discloses a radio stimulation surgical suture for promoting peripheral nerve healing and a preparation method and application thereof, the radio stimulation surgical suture comprises a Mo core layer and a PLGA coating; the preparation method of the radio stimulation operation suture comprises the following steps: preparing a core layer by using metal Mo, spraying out a PLGA spinning solution through a spinning nozzle, curing in a coagulating bath to form a film, and forming a uniformly coated PLGA coating on the Mo core layer through a wet spinning technology to obtain the radio stimulation operation suture for promoting peripheral nerve healing, according to the prepared radio stimulation surgical suture, energy is obtained from an external electromagnetic field in an electromagnetic induction and capacitance coupling mode, and a stable electric field is formed on the suture and the local part of a wound, so that the electric field acts on damaged tissue. The suture can promote neuronal axon growth, Schwann cell migration and the like, and the nerve tissue regeneration efficiency is improved.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor. Parkinson tremor, and other forms of tremor. Stimulation of nerves using machine learning algorithms are provided in certain aspects.

The invention provides a piezoelectric dressing for promoting nerve repair of a diabetic wound and a preparation method and application of the piezoelectric dressing, and belongs to the technical field of piezoelectric dressings. The preparation method comprises the following steps: firstly, respectively preparing a polymer solution and a conductive polymer dispersion liquid, then mixing the polymer solution and the conductive polymer dispersion liquid, carrying out secondary stirring to obtain an electrostatic spinning solution, and then carrying out electrostatic spinning and post-treatment in sequence to obtain the piezoelectric dressing for promoting neural restoration of the diabetic wound. By optimizing the ratio of the raw materials and cooperating with an electrostatic spinning process, triple functions of high-strength piezoelectric response, peripheral nerve repair and macrophage polarization regulation are realized, and the separation limitation of the prior art on nerve repair and immune microenvironment dynamic regulation is broken through; and an integrated solution of electrical stimulation, nerve regeneration, immune regulation and wound healing is provided for the diabetic wound.

Systems, devices, and methods for stimulating peripheral nerves in the fingers or hand to treat tremor are described. For example, a wearable ring device for delivering electrical stimulation to sensory nerves in a patient's finger can include an annular ring having a plurality of electrodes and a detachable unit having a power source and a pulse generator.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate at least one of tremor feedback, external data, predictive adaptation, or long-term monitoring data. The device may be configured as a wrist worn device to stimulate three nerves to provide tremor reduction.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

The present disclosure relates to compositions for increasing acetylated alpha-tubulin levels in peripheral neuronal cells. The present disclosure also relates to the use of tubulin deacetylase inhibitors, or activators of tubulin acetylation for increasing acetylated tubulin levels in the cells. The present disclosure also relates to methods for assessing risk of developing peripheral neuropathy by assessing the levels of acetylated alpha-tubulin. The present disclosure further relates to methods for treating a subject suffering from a peripheral neuropathy using the compositions described herein.

The invention relates to the technical field of biomedical materials, in particular to a high-conductivity peripheral nerve socketed pipe and a preparation method thereof. The nerve socketed pipe is a hollow cylindrical socketed pipe made of a material containing poly (octylene-citrate-co-octanol) POCO, and a regeneration promoting material is loaded in the hollow cylindrical socketed pipe; the regeneration promoting material comprises fetal calf serum and a DMEM cell culture medium. The POCO has the advantages of conductive activity, nerve regeneration induction, free radical scavenging ability, oxidation resistance, deformation resistance and the like, and has good degradability and biocompatibility, so that the nerve socketed pipe is prepared from poly (octylene-citrate-co-octanol), and the growth of axons is accelerated through electrical stimulation. Furthermore, at least one conductive monomer of pyrrole, aniline, p-phenylenediamine, o-methoxyaniline, thiophene, 3-hexylthiophene, 3-thiopheneacetic acid and 3, 4-ethylenedioxythiophene is adopted for modifying the POCO hollow cylindrical socketed pipe through in-situ oxidative polymerization, and the performance of the POCO hollow cylindrical socketed pipe serving as the neural restoration material is further improved.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulator may be inductively charged in certain aspects. The stimulation device can be configured to be worn on the wrist of a user.

The application provides a peripheral nerve precise regulation method and system based on a multi-channel flexible electrode, and is applied to the technical field of data processing. The physiological parameter information of a target user is processed based on a target peripheral nerve stimulation model to generate a muscle contraction characteristic comprehensive index, wherein the muscle contraction characteristic comprehensive index includes a muscle contraction amplitude, a contraction frequency, and the contraction frequency is clearly distinguished according to fast muscle, slow muscle and different movement modes. The training purpose information and the muscle contraction characteristic comprehensive index of the target user are processed based on the target peripheral nerve stimulation model to generate a preliminarily adjusted muscle contraction signal. The preliminarily adjusted muscle contraction signal is processed based on the physiological characteristic information of a target organ to generate a secondarily adjusted muscle contraction signal. The secondarily adjusted muscle contraction signal is processed based on the movement intensity interval information of the target organ to generate a target peripheral nerve stimulation signal.

Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.