106 results about "Ultrasonic stimulation" patented technology

The present invention relates to a device for the ultrasonic stimulation of a neural tissue. A control and data communication unit receives a control command to generate a pulse parameter and a beam-forming parameter. The ultrasonic echo radio frequency data outputted by an echo receiving unit is received and is transmitted to a control and ultrasonic imaging unit. A pulse excitation unit generates a high voltage pulse sequence according to the pulse parameter. The echo receiving unit composes ultrasonic echo radio frequency data according to the beam-forming parameter by using ultrasonic echo. The control and ultrasonic imaging unit emits a control command according to a user operation. The ultrasonic imaging of a target neural tissue scanning area is carried out according to the ultrasonic echo radio frequency data. An ultrasonic transducer array is controlled to be in a neural simulation state or an ultrasonic imaging state according to the high voltage pulse sequence. According to the technical scheme of the utility model, a method of sharing the ultrasonic transducer array by ultrasonic stimulation and ultrasonic imaging is employed, the real-time visualization of an ultrasonic neural stimulation process is realized, and the dynamic adjustment of stimulation target position and stimulation effect evaluation is helped.

The invention discloses a transcranial ultrasound stimulation cranial-nerve-function-repairing device and a method. The device comprises a function signal generator, a power amplifier, and an ultrasonic transducer, wherein after the function signal generator produces stimulation signals needed by stimulation, the stimulation signals are amplified though the power amplifier to high voltage pulse signals needed by the ultrasonic transducer and then ultrasonic stimulation signals are obtained through the ultrasonic transducer to stimulate brain tissue. The transcranial ultrasound stimulation cranial-nerve-function-repairing device and the method can achieve the purposes of low-power, high-resolution, and non-invasive neural restoration treatment.

The invention discloses a transcranial ultrasonic brain regulating and controlling method and device. According to the transcranial ultrasonic brain regulating and controlling method, short-pulse ultrasounds generated by a focused ultrasonic transducer pass through an ultrasonic coupling medium and then are transmitted to the head of a sample, and then nervous physiological change is caused by the mechanical effect; a focused ultrasonic detector is driven by a three-dimensional electric scanning platform to achieve scanning and then ultrasonic stimulation is carried out on different parts of the head. The transcranial ultrasonic brain regulating and controlling device comprises a water tank filled with the ultrasonic coupling medium, the focused ultrasonic transducer, a power amplifier, a signal generator, the three-dimensional electric scanning platform, a driving motor, a computer provided with motor control software, a connecting rod and a plastic film, wherein the focused ultrasonic transducer, the power amplifier and a function generator are electrically connected in sequence, the three-dimensional electric scanning platform, the driving motor, and the computer provided with the motor control software are electrically connected in sequence, and the focused ultrasonic transducer is connected with the three-dimensional electric scanning platform through the connecting rod. The transcranial ultrasonic brain regulating and controlling method and device have the advantage of being capable of achieving multidirectional transcranial ultrasonic brain regulation and control.

An electronic system for determining the density and structure of bone tissue and stimulating osteogenesis in dentistry, having a diagnosis system for injecting an ultrasonic signal U(t) into a bone portion and analyzing the ultrasonic signal received after traveling through the bone portion to determine a number of characteristic data items of the signal describing physical and structural characteristics of the bone tissue. The diagnosis system performs a number of measuring steps to determine and memorize a set of characteristic data items describing progress of a bone growth process and / or a bone repair process following extraction of a tooth and / or placement of a dental prosthesis in the bone portion. The system also has an osteogenesis stimulation system for directing an ultrasonic stimulation sign al onto the bone portion to promote the bone growth and / or bone repair process.

SLA-based additive manufacturing using radiation-curable foams enables the production by 3D printing of lightweight parts having desirable physical and functional attributes. A representative method of manufacturing such items includes processing a radiation-curable resin in liquid form to produce a stable, non-aqueous radiation-curable foam, on-demand deposition of the foam at a build layer of a build surface within a 3D printer, and then curing the non-aqueous radiation-curable foam to produce a layer of a 3D build item. Processing the resin typically includes agitation, mixing, shaking, gas injection, ultrasonic stimulation, or combinations thereof. 3D articles of manufacture made by the above-described manufacturing process are also provided.

The invention discloses a system for transcranial ultrasonic stimulation of mouse and synchronous acquisition of electroencephalogram and electromyogram signals and relates to the field of transcranial ultrasonic stimulation research and synchronous signal acquisition. The system comprises a transcranial ultrasonic stimulation module, a pulse transcranial ultrasonic signal generation module, a brain myoelectric signal acquisition and processing module and a power supply. The device has a series of advantages of stable signal acquisition, strong expansion storage capacity, portability, small size, easiness in operation and the like, and can be effectively applied to real-time synchronous acquisition of electroencephalogram and electromyogram signals of conscious and freely movable mice in transcranial ultrasonic stimulation experiments of various samples. Moreover, the storage module is expanded, and the problems of overlarge storage amount of long-time use data, distortion of wirelesstransmission data and the like are avoided. The system is convenient for subsequent off-line processing of brain myoelectric signals stimulated by transcranial ultrasound, and provides technical support for future mechanism research of transcranial ultrasound stimulation and clinical application of neuromodulation technology.

The invention provides a system for synchronizing transcranial ultrasonic stimulation and electroencephalography recording of the human body, which comprises a computer (110) containing control software, a signal generator (130), a radio frequency amplifier (140), an ultrasonic transducer (150), a synchronization control module (120), a transducer-scalp coupling module (151), an electroencephalography system (160) and a signal receiving terminal (161), and is characterized in that real-time communication between the signal generator (130) and the electroencephalography system (160) can be realized by using the synchronization control module (120), and complete synchronization of ultrasonic stimulation and electroencephalographic signal collection is realized. The system provided by the invention for synchronizing transcranial ultrasonic stimulation and electroencephalography recording of the human body can be applied to basic brain cognitive function research and clinical brain disease intervention treatment research, can realize synchronization of ultrasonic stimulation and electroencephalographic signal recording and solves the technical problems of multi-channel synchronous or asynchronous independent ultrasonic stimulation and corresponding electroencephalographic signal synchronous recording and stimulation marking.

A system and method are disclosed for providing therapeutic treatment using a combination of ultrasound and vibrational stimulation. The system includes a first therapeutic treatment system or Dynamic Motion Therapy system having a vibrational assembly having a non-rigidly supported platform for generating resonant vibrations. The system further includes a second therapeutic treatment system configured to operate either alone or in conjunction with the first therapeutic treatment system. The second therapeutic treatment system includes an ultrasound transducer assembly which generates ultrasonic waves. In one embodiment, the ultrasonic waves are modulated by the resonant vibrations. One method includes: a) applying vibrational stimulation to a patient's body; and b) simultaneously or non-simultaneously applying an ultrasonic stimulation to the patient's body during a treatment session.

The invention provides a multi-element transducer element selection device and method and an ultrasonic stimulation system. The ultrasonic stimulation system comprises an image acquisition device which is used for acquiring a lesion tissue region image, and an image processing device which is used for processing the lesion tissue region image to determine the position, size and lesion degree of a lesion tissue. The multi-element transducer element selection device is used for selecting a corresponding element in a multi-element transducer, carrying out delayed adjustment on the phase of an excitation pulse signal to be transmitted by the corresponding element channel, determining the focus depth, setting the parameters of an ultrasonic transmitting sequence, and controlling the multi-element transducer to start according to the focus depth and the transmitting sequence parameters. The selected corresponding element in the multi-element transducer transmits ultrasound to carry out ultrasonic stimulation on the lesion tissue. According to the invention, ultrasound is used to stimulate the lesion tissue of the heart and cerebral vessels; cardiovascular and cerebrovascular diseases are regulated; and the tissue on an ultrasound path is not damaged.

A fuel injector intended for use on an internal combustion engine contains an injector needle that is longitudinally driven by an ultrasonic actuator during the time the injector valve is open to provide an atomized fuel spray output of sub-micron droplet sizes. A piezoelectric disk stack is mounted within the injector housing to surround a portion of the injector needle component and is used to provide the mechanical ultrasonic stimulation to the injector valve at the end of the injector needle and set up a corresponding wave-front at the injector valve to atomize the fuel as it leaves the injector nozzle.

The invention relates to a wirelessly-controlled wearable ultrasonic nerve stimulation apparatus which includes: a user control terminal, a control emission chip, an ultrasonic energy transducer and a surface mount device housing. The user control terminal is intended for inputting a stimulation pulse mode and relevant stimulation waveform parameters, generating a corresponding control instruction and wirelessly transmitting the control instruction to the control emission chip. The control emission chip is intended for receiving the control instruction, generating a corresponding stimulation electric impulse waveform and driving the ultrasonic energy transducer. The ultrasonic energy transducer is intended for transforming the stimulation electric impulse waveform to an ultrasonic stimulation wave beam, and acting on a stimulation target. The surface mount device housing is intended for packaging the control emission chip and the ultrasonic energy transducer, and performing contact and fixing with the stimulation target. According to the invention, the apparatus realizes minimization and intelligent control of the stimulation apparatuses, and is in particular suitable for conducting long-time stimulation process on an acting target which is under normal free state.

Disclosed is a method for producing exosomes having effects of skin regeneration and wound healing, comprising the steps of: providing ultrasonic stimulation directly or indirectly to cells; culturinga mixture of the cells and a medium for a predetermined amount of time; and separating exosomes from the mixture, wherein direct provision of stimulation is the application of ultrasonic stimulationto a medium comprising cells, and indirect provision of stimulation is the application of ultrasonic stimulation to a medium that does not comprise cells and then mixing the medium with the cells. Theexosome production method enables exosomes, having effects of skin regeneration and wound healing, to be obtained in a high yield and short amount of time by means of a simple process called sonication from stem cells, which are difficult to be handled, and also from somatic cells, which can be easily obtained and maintained. The exosomes obtained thereby also have a high amount and number of various included factors, the exosomes and compositions comprising same have increased various factors, which can induce skin regeneration and wound healing, and the exosomes have a phospholipid-based membrane structure so as to facilitate skin penetration and allow high efficiency of substance delivery, thereby enabling skin regeneration and wound healing to be effectively induced, and are safe andhave no side effects caused by the use of synthetic drugs.

The invention discloses a method for controlling movement of a woundless rat robot. The conventional animal robot has the defects of difficult development process and low success rate by adopting a creative movement control mode. The invention adopts a mode of integrating ultrasonic stimulation with epidermal electrode stimulation and LED light auxiliary stimulation, wherein the ultrasonic stimulation is used for stimulating sense of hearing; the epidermal electrode stimulation is used for stimulating sense of pain; and the LED light auxiliary stimulation is used for stimulating sense of vision to make the rat robot have active escape behavior so as to control the movement of the rat robot. The method for controlling movement by adopting a woundless rat movement control mode has the advantages of solving the problems of neurolysis, difficult operation and the like in creative stimulation control, accelerating practical process, along with no need of craniotomy on the rat, short development cycle, and wide development potential in aspects of personnel search and rescue, military activities, and acquisition of physiological parameters of organisms in the future.

The invention discloses a portable ultrasonic detector for a railway power supply net touching pin. The detector is composed of a main controller, an ultrasonic signal stimulation receiving module, an input / output device and a power module. The main controller is composed of a single-chip field programmable gate array (FPGA). An ultrasonic stimulation receiving circuit of the ultrasonic signal stimulation receiving module emits a high-voltage pulse under the control of the FPGA to stimulate an ultrasonic transducer. The power module produces high-voltage direct current through a battery in a direct-current boosting mode. The ultrasonic transducer is connected with the pin and produces ultrasonic waves transmitted to the pin through a coupling agent. The ultrasonic waves are reflected by the end face or cracks of the pin and are received by the same transducer again. After operation is conducted on echo signals, echo waveforms are displayed on a screen, whether defects exist or not is automatically recognized, and the defects are used for further analysis. The portable ultrasonic detector has the advantages that operation is easy, and the detection efficiency is high; based on the single-chip FPGA, the structure is compact, power consumption is low, the weight is low, and requirements of detection on site are met due to battery power supply.

The invention provides a transcranial ultrasonic stimulation device and a stimulation method for carrying out nervous tissue orientation and neuromodulation through transcranial ultrasonic stimulation. The transcranial ultrasonic stimulation device comprises an upper computer unit, an ultrasonic pulse transmission unit, an ultrasonic transduction unit and a power circuit. The transcranial ultrasonic stimulation device adopts the integrated circuit mode and further comprises an echo amplification circuit. The focal distance of the ultrasonic transduction unit is 30 mm. The ultrasonic pulse transmission voltage is adjusted by adjusting the power supply voltage, and therefore the transcranial ultrasonic stimulation device is small in size and high in spatial orientation resolution ratio and can achieve system self-inspection. Meanwhile, because the ultrasonic intensity can be adjusted, a low ultrasonic intensity can be selected for carrying out nervous tissue orientation and neuromodulation, a high ultrasonic intensity can be selected for carrying out tissue damage, and the positional information of the stimulation part can be verified.

The invention discloses an application of a tin disulfide / carbon nanofiber composite material in degradation of organic pollutants, which comprises the following steps: putting a carbon nanofiber membrane into a precursor solution containing a tin source and a sulfur source, reacting, and drying to obtain the tin disulfide / carbon nanofiber composite material, and putting the tin disulfide / carbon nanofiber composite material into water containing organic pollutants, and then carrying out ultrasonic treatment to remove the organic pollutants in the water. According to the method, different technical ideas are utilized, the purpose of catalytically degrading the organic pollutant bisphenol A through pure SnS2 is achieved, and in the catalytic process, SnS2 can efficiently remove the organic pollutant under ultrasonic stimulation.

The invention discloses an ultrasonic contrast agent and a preparation method thereof, and belongs to the technical field of ultrasonic imaging. The contrast agent is composed of a spherical wall, aninner gas and a solution. The spherical wall is made of Span 60, Tween 80 and polyethylene glycol; the inner gas is a composition of plasma and inert gas; and the solution is a phosphate buffer solution. The ultrasonic contrast agent has good response to ultrasound for clinical diagnosis, and plasmas in the inner gas can be released through ultrasonic mediation and is used for killing tumor cellsin a targeted mode. Ultrasonic diagnosis and treatment are combined. A diseased part is locked through ultrasonic contrast, then ultrasonic stimulation is applied, and treatment under the guidance ofultrasonic images is conducted. The treatment efficiency is improved while the pain of a patient is relieved. In addition, the ultrasonic contrast agent has the advantages of long stabilization time,good using effect and long circulating half-life period.

The invention discloses a portable double-channel transcranial ultrasonic stimulation device for neuromodulation. The device is used for outputting an ultrasonic signal matched with an ultrasonic probe and comprises a main control unit, a signal generator unit, a power amplifier unit, a resonant impedance matching unit, a display control panel unit and a power supply system unit; the device comprises a first channel and a second channel which are mutually independent; the first channel comprises a first ultrasonic excitation signal branch and a first external trigger signal branch which are connected with the main control unit; the second channel comprises a second ultrasonic excitation signal branch and a second external trigger signal branch which are connected with the main control unit; the device also comprises an external cooperative unit; and the working mode of the external cooperative unit comprises a synchronous trigger mode and an asynchronous trigger mode. The transcranialultrasonic stimulation device provided by the invention is simple in work integration, flexible in control and rich in function, and can meet the neuromodulation requirements of various stimulation modes.

The invention is suitable for the technical field of medical treatment, and provides an ultrasonic stimulation method and device, wherein the method comprises the steps: obtaining an ultrasonic stimulation target region of an organ; adjusting a fixed position of an ultrasonic transducer based on each stimulation detection point determined in the ultrasonic stimulation target area; determining a target stimulation target point from the stimulation detection points based on stimulation feedback results of ultrasonic stimulation at different fixed positions; and on the basis of the target stimulation target point, carrying out ultrasonic stimulation operation, wherein the convenience of finding the target point is improved, and the accuracy of the ultrasonic stimulation operation is improved.

The invention relates to a wearable mouse brain stimulation ultrasonic transducer. The wearable mouse brain stimulation ultrasonic transducer comprises a circulator and a piezoelectric array element;a backing block is embedded in the circulator; the piezoelectric array element is connected with the backing block; the piezoelectric array element includes a piezoelectric material layer; one side surface of the piezoelectric material layer has a concave surface, and the shape of the concave surface matches the outer contour shape of a mouse brain skull; an outer electrode is arranged on the concave surface; an inner electrode is arranged on the other side surface of the piezoelectric material layer; an installation hole for installation of an SMA interface is formed in the backing block; theouter electrode is electrically connected to a threaded electrode of the SAM interface; and the inner electrode is connected to a central electrode of the SAM interface. In the technical scheme, thetransducer can achieve focusing by using the concave surface, a large amount of energy is projected to a small area to achieve nerve stimulation; MRI is the highest monitoring method for biological tissue resolution in the prior art, the mouse brain is small, MRI detection can be performed during ultrasonic stimulation so as to achieve a similar real-time detection effect.

A vacuum negative pressure ultrasonic transdermal drug delivery device is composed of a negative pressure unit for generating dermal negative pressure suction and an air pumping bag for generating negative pressure in the negative pressure unit. The air pumping bag and the negative pressure unit are in fixed connection through a thread. The top of the air pumping bag is provided with an air pumping check valve and a valve fixing tube for fixing the air pumping check valve. An ultrasound unit acting on the human body is arranged in the negative pressure unit. The vacuum negative pressure ultrasonic transdermal drug delivery device has the advantages of being tight in drug delivery space, achieving the effects of dermal looseness, intradermal congestion, epidermis stratum corneum fracture, keratinocyte gap increasing and obvious skin resistance decreasing through the action of negative pressure and providing transdermal drug delivery power for a drug under the ultrasonic stimulation, thereby improving the transdermal efficiency of the drug, increasing the transdermal penetration amount of the drug and enhancing the therapeutic effect accordingly.

An electronic system for determining the density and structure of bone tissue and stimulating osteogenesis in dentistry, having a diagnosis system for injecting an ultrasonic signal U(t) into a bone portion and analyzing the ultrasonic signal received after traveling through the bone portion to determine a number of characteristic data items of the signal describing physical and structural characteristics of the bone tissue. The diagnosis system performs a number of measuring steps to determine and memorize a set of characteristic data items describing progress of a bone growth process and / or a bone repair process following extraction of a tooth and / or placement of a dental prosthesis in the bone portion. The system also has an osteogenesis stimulation system for directing an ultrasonic stimulation signal onto the bone portion to promote the bone growth and / or bone repair process.

The invention discloses a non-invasive blood pressure regulation system based on ultrasonic nerve stimulation. The system comprises a blood pressure monitoring device, a central control circuit and anultrasonic stimulation device, wherein the blood pressure monitoring device is used for monitoring, displaying and storing the blood pressure, and sending the monitored blood pressure values to the central control circuit; the central control circuit is used for receiving the blood pressure values sent by the blood pressure monitoring device, switching different ultrasonic nerve stimulation modesaccording to the changing situations of the blood pressure values and outputting control instructions; the ultrasonic stimulation device is used for receiving the control instructions output by the central control circuit and conducting ultrasonic nerve stimulation in different ultrasonic nerve stimulation modes according to the control instructions so as to achieve blood pressure regulation. Theultrasonic stimulation device comprises a random waveform generator, a power amplifier, an impedance matcher, a switching selector, a focused ultrasonic transducer group and a signal feedback device.By means of the non-invasive blood pressure regulation system, while it can be achieved that the blood pressure is monitored in real time, non-invasive blood pressure regulation can be conducted according to a set blood pressure threshold, and the blood pressure is kept to be stable.

The invention discloses retina stimulation equipment based on two-dimensional array probes, and the equipment comprises a lens frame and the two-dimensional array probes, wherein the two-dimensional array probes are installed in the lens frame, and the lens frame is provided with a camera device, an integrated circuit, and a power supply. Coupling parts are disposed between the two-dimensional array probes and eyes. The camera device is used for collecting image information and transmitting the image information to the integrated circuit. The integrated circuit is used for converting the image information into an electric signal and transmitting the electric signal to the two-dimensional array probes. The two-dimensional array probes are used for generating ultrasound under the excitation of the electric signal, and achieving the ultrasonic stimulation of the retinas. The power supply is used for supplying power to the camera device and the integrated circuit. After a dysopia person wears the equipment, the integrated circuit enables the image information collected by the camera device to be converted into the electric signal, and the electric signal is used for the excitation of the two-dimensional array probes, thereby forming a focused sound beam with a plurality of focuses. The ultrasound acts on optic nerve cells, and enables the dysopia person to sense the image information, and to recover the visual sensing function.

The invention provides a tartarian buckwheat seedling health-care beverage rich in flavone and a making method of the tartarian buckwheat seedling health-care beverage. The tartarian buckwheat seedling health-care beverage contains 20%-45% of tartarian buckwheat juice, 20%-35% of licorice root juice, 20%-35% of honeysuckle flower juice, 0.05%-0.1% of citric acid, 0.01-0.025% of malic acid, 0.01%-0.025% of sodium citrate, 3%-8% of xylitol, 3%-6% of trehalose, 0.005%-0.01% of ethyl maltol and 0.2%-0.4% of a composite stabilizer, wherein the total of the raw materials is 100%. Compared with the prior art, the tartarian buckwheat seedling health-care beverage rich in flavone provided by the invention has the advantages that flavone-enriched tartarian buckwheat seedlings which are obtained through ultrasonic stimulation and illumination culture, licorice roots and honeysuckle flowers are used as the raw materials, the xylitol and the like which have the effect of reducing blood sugar are used as auxiliary materials, the content of the flavone reaches 550-570mg / L, the tartarian buckwheat seedling health-care beverage has health-care functions, and requirements of consumers for mouth feeland health are met.

The present invention discloses an ultrasonic retina stimulation device. The ultrasonic retina stimulation device comprises a spectacle frame and spectacle glasses; an ultrasonic transducer, a first data transmitter-receiver device, an energy receiving device and an integrated chip are disposed in each spectacle glass substrate; the spectacle frame is provided with camera devices, integrated circuits, second data transmitter-receiver devices, energy transmission devices and power supplies; the camera devices are used for acquiring image information; the integrated circuits are used for converting the image information into image data and transmitting the data to the integrated chips through the data transmitter-receiver devices; the integrated chips are used for converting the image data into stimulation signals; the ultrasonic transducers are used for performing ultrasonic stimulation on retinas under stimulation of the stimulation signals; and the power supplies supply the camera devices, the integrated circuits and the second data transmitter-receiver devices with power, and supply the integrated chips and the first data transmitter-receiver devices with power through the energy transmission devices and the energy receiving devices. When a visual function disorder wears the device, the ultrasonic transducers are stimulated to form focusing acoustic beams having a plurality of focuses, optic nerve cells are stimulated, and the visual perception function is recovered.

The invention provides a closed-loop transcranial brain stimulation system and method. The system comprises a transcranial ultrasonic signal generation module, a transcranial ultrasonic stimulation module, an electroencephalogram and electromyogram signal acquisition and processing module and an electrode module; the electrode module is used for collecting brain muscle signals of an experimental subject; the electroencephalogram and electromyographic signal collecting and processing module is configured to be used for collecting signals of the electrode module, processing the signals and then sending detection signals to the transcranial ultrasonic signal generating module; the transcranial ultrasonic signal generation module is configured to receive the detection signal, generate a stimulation signal according to the detection signal and an adjustment strategy, and send the stimulation signal to the transcranial ultrasonic stimulation module; the transcranial ultrasonic stimulation module is configured to emit ultrasonic stimulation to the experimental subject according to the stimulation signal. The beneficial effects of the invention are that the transcranial ultrasonic signal generation module adjusts the signal parameters of the transcranial ultrasonic stimulation module to the experimental subject next time according to the brain and muscle signals collected by the electrode module and a system expected value through a configuration strategy, thereby achieving the closed-loop control of the transcranial brain stimulation.

The invention relates to an ultrasonic stimulation device and ultrasonic stimulation method for promoting proliferation and differentiation of spinal cord-derived neural stem cells. The device is provided with a power supply, a driving signal generator, a pulse repetition frequency generator, a power amplifier, an ultrasonic probe and a hydrophone, wherein the driving signal generator converts a common current into a high-frequency current, the pulse repetition frequency generator generates a pulse signal with a repetition frequency from the high-frequency current, the power amplifier amplifies the pulse signal, and finally the ultrasonic probe emits an ultrasonic wave from the amplified pulse signal, the hydrophone is used for receiving acoustic signals in liquid, the ultrasonic probe iscylindrical and an isolation vessel is arranged above the ultrasonic probe. According to the method, primary cultured spinal cord-derived neural stem cells are subjected to ultrasonic stimulation at an intensity of 10-150 mW / cm2. The method is suitable for researching influence of ultrasound on the proliferation and differentiation of the spinal cord-derived neural stem cells. The device utilizeslow-frequency pulse ultrasound to stimulate the spinal cord-derived neural stem cells, promotes the proliferation and differentiation of the spinal cord-derived neural stem cells, and further promotesrepair of spinal cord injury.

A guide framework for positioning an ultrasonic transducer which emits a focused ultrasound to a target point in carrying out surgery to apply ultrasonic stimulation to a subject's brain, includes a body in a shape of a mask that is laid on the subject's face, and a positioning hole formed through an inner surface and an outer surface of the mask body, the positioning hole into which the ultrasonic transducer is inserted, wherein the inner surface of the mask body is formed to conform a facial contour of the subject, and when the guide framework is laid on the subject's face and the ultrasonic transducer is disposed at the positioning hole, the position of the target point is naturally disposed at a preset stimulation site of the brain. An ultrasonic stimulation device includes an ultrasonic transducer and the guide framework for positioning the ultrasonic transducer.

The invention relates to an intensified biological treatment device and method for degradation-resistant organic nitrogen-rich chemical wastewater. The intensified biological treatment method comprises the following steps that when wastewater enters a water distributor from a water inlet system, sprinkled into the bottom of a hydrolytic acidification reactor, then flows into a water outlet system from bottom to top, and enters an anoxic zone of a membrane bioreactor; under the action of electrodes, the wastewater enhances the activity of denitrifying bacteria, and nitrogen removal by denitrification is achieved; the wastewater then enters an aerobic zone of the membrane bioreactor, ultrasound generated by an ultrasonic generator is transmitted into an energy converter, and ultrasonic stimulation is conducted on the wastewater to remove organic materials and ammonia nitrogen; the wastewater is pumped out of the membrane bioreactor though a membrane module and enters a water outlet end. The synergistic effect of hydrolytic acidification and the membrane bioreactor is fully utilized, the biodegradability can be improved by hydrolytic acidification, and the problems that degradation is difficult in the aerobic process, the organic materials are slow in degradation and organic loading is low are avoided; then the sludge concentration is improved by means of the membrane bioreactor, and the organic materials and ammonia nitrogen are further degraded.