18 results about "Ultrasonic stimulation" patented technology

A biomimetic intervertebral fusion device with a piezoelectric multifunctional coating belongs to the field of implantable medical devices. It includes an upper piezoelectric multifunctional coating, a fusion device body, and a lower piezoelectric multifunctional coating. A bone graft window is located in the middle of the biomimetic intervertebral fusion device. The piezoelectric multifunctional coating is made of electrospun piezoelectric PVDF / HA fibers, which are conformally adhered to the upper and lower surfaces of the fusion device body through a polydopamine adhesive layer. The upper and lower surfaces of the fusion device body have a biomimetic curved surface configuration to match the morphology of the vertebral endplates, increasing the contact area and reducing stress concentration at the fusion interface. While maintaining an elastic modulus similar to natural bone and good radiation permeability, this fusion device, after implantation, can create a microenvironment conducive to cell adhesion and proliferation. Under the influence of cell traction, ultrasonic stimulation, and the physiological load of the human lumbar spine, it generates electrical stimulation signals, promoting bone fusion, improving the stability of the fusion interface, and reducing the risk of postoperative loosening and subsidence of the fusion device.

The present application relates to the technical field of biological cell culture, and particularly relates to a fixed bed device and method for improving secretion and expression of exosomes. The device comprises a fixed bed reactor, an ultrasonic generator, a connecting flange and a control unit. The ultrasonic generator is installed on the top of the fixed bed reactor through the connecting flange. The control unit is configured to control the ultrasonic generator to apply ultrasonic stimulation to the cells intermittently in the whole cycle of cell culture. The ultrasonic intensity is dynamically regulated in three stages according to the culture cycle. The present application uses pure physical stimulation without adding chemical reagents. Under the premise of maintaining normal growth and activity of cells, the yield of exosomes can be increased by more than 169%. The present application is suitable for animal cells and plant cells and has a wide industrial application prospect. The technical problems of low yield of exosomes, stimulation mode that may affect cell activity or introduction of chemical reagents that may interfere in the prior art can be effectively solved.

The application relates to application of a piezoelectric material in preparation of a medicine for treating gout, characterized in that a medicine active ingredient of the medicine comprises the piezoelectric material, the piezoelectric material is barium titanate; the application comprises the following steps: delivering the medicine to a lesion site, applying ultrasonic stimulation to the lesion site, and exciting in-vivo active species degradation of uric acid by the medicine. The piezoelectric material has good piezoelectric catalytic performance, excellent tissue penetration ability, low toxicity and high precision, active species can be controllably excited by means of ultrasonic action at the time of gout attack, uric acid can be efficiently degraded into allantoin which is good in solubility and non-toxic, symptoms can be rapidly relieved, the piezoelectric material can be long-term resident in joints, can keep stable catalytic effect in multiple cycles, and long-term treatment of gout can be realized by single injection, and a new gout treatment scheme which is more effective and more durable is provided.

SLA-based additive manufacturing using radiation-curable foams enables the production by 3D printing of lightweight parts having desirable physical and functional attributes. A representative method of manufacturing such items includes processing a radiation-curable resin in liquid form to produce a stable, non-aqueous radiation-curable foam, on-demand deposition of the foam at a build layer of a build surface within a 3D printer, and then curing the non-aqueous radiation-curable foam to produce a layer of a 3D build item. Processing the resin typically includes agitation, mixing, shaking, gas injection, ultrasonic stimulation, or combinations thereof. 3D articles of manufacture made by the above-described manufacturing process are also provided.

This invention provides an antibacterial and repair-promoting piezoelectric film, its preparation method, and its application, belonging to the field of piezoelectric material technology. The method involves in-situ self-assembly of Fe-MOF on the surface of BTO, followed by further loading with DHA to synthesize an electrically controlled drug-release, antibacterial, and repair-promoting nanocomposite, BTO / Fe-MOF / DHA. BTO / Fe-MOF / DHA is then added to the surface of semi-cured PDMS to form an antibacterial and repair-promoting piezoelectric film, PDMS-BTO / Fe-MOF / DHA. When the PDMS-BTO / Fe-MOF / DHA piezoelectric film is subjected to ultrasonic stimulation, BTO converts mechanical energy into electrical energy, releasing Fe from the Fe-MOF... 3+ Reduced to Fe 2+ Fe-MOF degrades and releases DHA, and ultimately, Fe... 2+ Reacting with synchronously released DHA, it produces a large amount of toxic ROS, which damages proteins and nucleic acids, inducing bacterial death. The antibacterial and repair-promoting piezoelectric membrane of the present invention generates a piezoelectric potential during mechanical deformation caused by animal movement and induces EF at the wound site to promote wound healing. This antibacterial and repair-promoting piezoelectric membrane shows great potential in the future treatment of bacterial infected wounds.

The application discloses a kind of attenuated salmonella load adjuvant nano combination medicine, the combination medicine is modified to bacterial surface by means of amino and carboxyl condensation reaction, adamantane is simultaneously modified to adjuvant nano medicine surface using diselenium dynamic bond, then the host-guest interaction of adamantane and cyclodextrin is used to assemble two, and then nano medicine is stably combined on the surface of attenuated salmonella.Diselenium dynamic bond can be broken by ultrasound response, so as to realize the effect of drug release.This combination medicine has the tumor targeting enrichment ability of bacteria and the release characteristics of adjuvant nanoparticles under the action of ultrasonic wave, can realize targeted delivery and deep penetration in tumor tissue, and obtain significant tumor inhibition effect under ultrasonic stimulation.The experimental results show that the combination medicine exhibits good therapeutic effect in inhibiting tumor growth, and has excellent biological safety.

This invention discloses a bismuth-copper bimetallic coordination nanomaterial, its preparation method, and its applications, belonging to the technical field of biofunctional materials. The prepared bismuth-copper bimetallic coordination nanomaterial can efficiently generate reactive oxygen species (ROS) under ultrasonic stimulation, initiating the sonodynamic therapy (SDT) process; the Cu in this material... 2+ The weakly acidic environment of the tumor microenvironment can also trigger a Fenton-like reaction, generating cytotoxic hydroxyl radicals (•OH) and oxygen in situ, thus initiating the chemokinetic therapy (CDT) process. Through the synergistic effect of sonodynamic therapy (SDT) and chemokinetic therapy (CDT), they jointly inhibit cancer cell proliferation and promote T cell generation.

The application provides a method and device for constructing an electroacoustic coding model based on anisotropic conduction characteristics, and is applied to the technical field of biological signal processing. The method comprises the following steps: performing electrical stimulation and ultrasonic stimulation simulation on an anisotropic brain region model of a target object to obtain an electric field stimulation brain region model and an acoustic field stimulation brain region model; performing acoustic-electric intensity equalization on an electric field distortion brain region in the electric field stimulation brain region model and an acoustic field distortion brain region in the acoustic field stimulation brain region model respectively to obtain target electric field coding parameters and processing acoustic field coding parameters; based on the ultrasonic anisotropic conduction characteristics of the acoustic field distortion brain region, using acoustic anisotropic parameters, compensating and correcting the processing acoustic field coding parameters to obtain adaptive acoustic field coding parameters; according to a reference acoustic-electric coupling signal, feeding back and optimizing the adaptive acoustic field coding parameters to obtain target acoustic field coding parameters, and constructing a target acoustic-electric coding model according to the target electric field coding parameters and the target acoustic field coding parameters.

The application discloses a sonodynamic nanocatalyst and a preparation method and application thereof, the preparation method constructs a copper-centered organometallic molecule, which adopts an acceptor-donor-acceptor (A-D-A) structure design and can generate active oxygen under ultrasonic stimulation after being prepared into nanoparticles. In order to enhance tumor targeting and immune regulation functions, the sonodynamic nanocatalyst is wrapped with M1 macrophage membranes overexpressing PD-1, and is jointly loaded into a 3D printed bioadhesive GelMA-based hydrogel together with lipid nanoparticles loaded with a targeted CD300ld small interfering RNA, so that precise implantation of the cervical canal is realized. After ultrasonic activation, the system realizes tumor-killing ROS generation and selective silencing of PMN-MDSC-derived immunosuppression.

The application relates to the technical field of biological materials, and discloses an electrically stimulated LDH hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a zinc salt, a vanadium salt and urea in water under a nitrogen atmosphere to obtain a precursor solution; performing a hydrothermal reaction on the precursor solution to obtain ZnV-LDH; gradually adding methacrylic anhydride into a gelatin solution under stirring, heating and reacting; adding preheated water into the reaction solution to stop the reaction; performing dialysis purification, pre-freezing and freeze-drying on the reaction solution to obtain a hydrogel; and adding the ZnV-LDH into the hydrogel, ultrasonic mixing, and obtaining the electrically stimulated LDH hydrogel. Through the synergistic effect of the ZnV-LDH and the hydrogel, the electrically stimulated LDH hydrogel has electric activity, can respond to external stimulation to generate a potential change, can generate a concentration-dependent electric response under ultrasonic stimulation, and the response has periodicity and stability, so that the osteogenic differentiation and the cell mechanical properties can be promoted to the maximum extent.

This invention provides a method and application for in-situ construction of barium titanate piezoelectric nanozymes based on mesoporous silica. Mesoporous silica (MSNs) is used as a carrier, titanium acetylacetonate as the titanium source, barium chloride as the barium source, and ferric chloride hexahydrate as the iron source. After stirring for 24 h and then gradient calcination for 6 h, iron-doped barium titanate piezoelectric nanozymes grown in situ within the pores of MSNs are synthesized. The prepared material exhibits piezoelectric catalytic activity, capable of converting endogenous H2O in tumor cells into hydroxyl radicals (•OH) and O2 into superoxide anions (•O2) under ultrasonic stimulation. ‑ It also possesses peroxidase-like (POD) and superoxide dismutase-like (SOD) activities, and can utilize SOD-like activity to convert •O2 ‑ The process involves converting the generated H2O2 into H2O2, alleviating the H2O2 deficiency within the tumor microenvironment. Then, utilizing POD-like activity, the generated H2O2 and endogenous tumor-derived H2O2 are converted into •OH, achieving a piezoelectric catalysis and enzyme cascade reaction to further increase the •OH level, efficiently killing tumor cells and inducing tumor cell death. This strategy allows for the in-situ development of iron-doped barium titanate piezoelectric nanozymes that simultaneously achieve sonodynamic catalytic therapeutic performance and enzyme catalytic therapeutic performance within the channels of MSNs.

The application belongs to the technical field of biomedical materials, functional polymer materials and regenerative medicine, and particularly relates to a collagen-based composite piezoelectric hydrogel based on non-solvent induced phase separation and extrusion type 3D printing, a preparation method and application. The preparation method comprises the following steps: mixing collagen solution, polyvinylidene fluoride and barium titanate to prepare a composite bio-printing ink; the printing ink is deposited and formed layer by layer through extrusion type 3D printing, and a non-solvent is introduced during the printing process, so that the system undergoes non-solvent induced phase separation and realizes in-situ curing, and the collagen-based composite piezoelectric hydrogel is obtained. The prepared composite piezoelectric hydrogel has good printing formability, structural stability, biocompatibility and piezoelectric response performance, can form a stable porous composite network structure, and can generate electrical signal output under the condition of external mechanical stimulation or ultrasonic stimulation. The collagen-based composite piezoelectric hydrogel can be used for wound repair, and is particularly suitable for diabetic chronic wound repair.

The application discloses an antibacterial filler with pyroelectric and piezoelectric effects and a dental composite resin and a preparation method, relates to the technical field of dental repair materials, and adopts calcium-manganese co-doped barium titanate as a shell material to coat barium glass powder to form a core-shell structure. The calcium-manganese co-doping realizes the stabilization of the crystal structure of the barium titanate, significantly improves the pyroelectric response capability of the barium titanate at room temperature on the premise of maintaining the tetragonal phase, and makes the barium titanate have excellent pyroelectric and piezoelectric properties. The synergistic effect of the above-mentioned core-shell filler and a resin matrix makes the obtained composite resin be capable of inducing active oxygen under the stimulation of oral temperature cycle change or ultrasonic stimulation, so that a persistent antibacterial effect is realized. The composite material has excellent mechanical properties and good biocompatibility, and is suitable for application scenes with high requirements for antibacterial properties and functions in the field of oral repair.

This invention relates to the field of medical device technology and discloses an external vibration-electric stimulation device for erectile dysfunction (ED), comprising a shell, a fixing chamber fixedly connected to the top of the shell, a flexible heating layer fixedly connected to the inner diameter of the shell, multiple vibration motors fixedly connected inside the flexible heating layer, multiple ultrasonic transducers fixedly connected inside the flexible heating layer, a shape memory alloy support frame disposed within the inner diameter of the flexible heating layer, multiple micro-airbags disposed within the inner diameter of the shape memory alloy support frame, an inner bonding layer fixedly connected between the multiple micro-airbags, and an electrical stimulation electrode and a bioimpedance detection electrode disposed within the inner diameter of the inner bonding layer. By integrating multiple stimulation methods such as vibration stimulation, electrical stimulation, ultrasonic stimulation, and thermotherapy stimulation in the same external stimulation device and its corresponding method, and by having a controller uniformly schedule each stimulation component, multiple stimulation methods can be executed collaboratively in the same stimulation session.

This invention relates to the field of biomedical antibacterial nanomaterials technology, specifically to an L-arginine-functionalized TiO2. 2‑x Preparation method and application of MXene composite nanomaterials. The preparation method of this invention includes: preparing Ti3C2T using the LiF / HCl in-situ etching method. x MXene dispersion; Ti3C2T x MXene is mixed with glycerol and then subjected to a hydrothermal reaction, forming TiO2 in situ on the MXene surface. 2‑x TiO 2‑x -MXene; further functionalization with L-arginine yields LA@TiO 2‑x -MXene composite nanomaterials. The materials of this invention exhibit excellent near-infrared photothermal response and ultrasonic response acoustic dynamic activity, and can generate NO and ONOO under ultrasonic stimulation. ‑ The materials of this invention can be used to prepare anti-MRSA antibacterial materials, anti-biofilm materials, antibacterial dressings, or antibacterial coatings for medical device surfaces, exhibiting synergistic antibacterial effects of photothermal, acoustic dynamic, and active nitrogen species.

This invention provides a method and apparatus for constructing an electroacoustic coding model based on anisotropic conduction characteristics, applicable to the field of biosignal processing technology. The method includes: performing electrical and ultrasonic stimulation simulations on an anisotropic brain region model of a target object to obtain an electric field-stimulated brain region model and an acoustic field-stimulated brain region model; performing electroacoustic intensity equalization on the electric field-distorted brain regions in the electric field-stimulated brain region model and the acoustic field-distorted brain regions in the acoustic field-stimulated brain region model respectively to obtain target electric field coding parameters and processed acoustic field coding parameters; compensating and correcting the processed acoustic field coding parameters based on the ultrasonic anisotropic conduction characteristics of the acoustic field-distorted brain regions using acoustic anisotropic parameters to obtain adaptive acoustic field coding parameters; performing feedback optimization on the adaptive acoustic field coding parameters according to a reference electroacoustic coupling signal to obtain target acoustic field coding parameters; and constructing a target electroacoustic coding model based on the target electric field coding parameters and the target acoustic field coding parameters.

The application relates to a brain-computer regulation system for tinnitus with sleep disorders and a control method thereof. The method comprises the following steps: collecting brain electrical signals of a user to generate neural electrical activity data, and collecting sleep state physiological data to generate sleep stage information; extracting tinnitus-related abnormal neural activity features and sleep state-related neural activity features according to the neural electrical activity data, combining the sleep stage information to generate ultrasonic stimulation control parameters and determine a stimulation target; outputting low-intensity focused ultrasonic stimulation according to the ultrasonic stimulation control parameters, and updating the ultrasonic stimulation control parameters according to the change amount of the neural activity features before and after the stimulation after the stimulation is completed, so that closed-loop control of ultrasonic output is realized.

A gravitational cascade flow battery achieves practical energy density of 200 Wh / L through micro-encapsulated phase change materials and eliminates mechanical components using acoustically-controlled thixotropic flow. The system comprises a vertical tower where gel-state electrolyte slurries flow through cascaded reaction stages only when acoustic chokes locally liquefy the fluid through ultrasonic stimulation. Smooth micro-encapsulated spheres contain crystallizing active materials, preventing membrane and electrode abrasion while maintaining high energy density. Thixotropic behavior created by fumed silica prevents settling at rest but enables rapid flow under acoustic activation. A passive fail-safe system releases hot solvent upon power loss, gravity-flushing the cascade to prevent catastrophic solidification. The acoustic control provides precise digital flow modulation with <100 ms response time while achieving 80-82% round-trip efficiency. Applications include grid-scale energy storage, renewable energy integration, and underground installations utilizing natural or artificial vertical structures.