79 results about "Ultrasonic stimulation" patented technology

The invention discloses a self-adaptive closed-loop ultrasonic stimulation system and method based on Actor-Critic reinforcement learning, and belongs to the field of neural regulation and control technologies and biomedical engineering, and the system comprises a signal collection module, a preprocessing module, an Actor strategy module, a Critic value module, an ultrasonic stimulation module, a safety monitoring module and a storage module. The Actor strategy module generates safe and controllable ultrasonic stimulation parameters according to the preprocessed electroencephalogram data; the safety monitoring module is used for checking whether the ultrasonic stimulation parameters generated by the Actor module meet safety standards or not; the ultrasonic stimulation module sends out an ultrasonic stimulation signal according to the ultrasonic stimulation parameter; and the Critic value module evaluates the electroencephalogram feedback effect after ultrasonic stimulation and provides feedback to the Actor module for optimizing the experimental strategy of the next step. The invention aims to intelligently adjust the ultrasonic stimulation parameters through the biofeedback data monitored in real time in combination with the reinforcement learning algorithm.

The preparation method comprises the following steps: by taking an oriented polylactic acid nanofiber membrane as a raw material, carrying out homogenization treatment to obtain polylactic acid piezoelectric short fibers; gelMA is used as a skeleton matrix, polylactic acid short fibers, LAP and DRG cells are compounded, a 0 / 90-degree alternate grid structure scaffold is constructed through pneumatic extrusion type biological printing, and the dual-network piezoelectric biological scaffold is formed through blue light crosslinking curing. The piezoelectric effect of polylactic acid short fibers is activated through ultrasonic stimulation, mechanical energy is converted into local electric signals, loaded DRG cells are directly driven to secrete CGRP in situ, macrophages are dynamically regulated and controlled to be polarized to M2 anti-inflammatory phenotypes, nerve-immune microenvironment disorder of diabetic bone defects is corrected, vascularization and bone regeneration are promoted, and the diabetic bone defect treatment effect is improved. The problems of short delivery half-life period of traditional cell factors, difficulty in nerve function reconstruction and chronic inflammation caused by non-degradable piezoelectric materials are solved, and non-invasive and degradable precise bone repair is realized.

The invention relates to the field of treatment ultrasound, in particular to a heart rate regulation and control system based on focused ultrasound and application of the heart rate regulation and control system. The heart rate regulation and control system based on focused ultrasound comprises an ultrasonic stimulation module, a central control module and an electrocardiosignal acquisition module, the ultrasonic stimulation module is in communication connection with the central control module, and the electrocardiosignal acquisition module is in communication connection with the central control module. The heart rate regulation and control system based on focused ultrasound provided by the invention is controlled by the multi-degree-of-freedom mobile platform to noninvasively convey ultrasonic energy to a heart target region, so that the following effects are achieved: 1) the heart rate can be noninvasively and safely regulated; 2) the system is simple to operate; 3) the heart rate regulation and control effect is high in real-time performance; and 4) the heart rate regulation and control effect is obvious, and the heart rate can be increased by 10-40%.

The invention discloses MoSe2 nano-enzyme-selenium-rich probiotic composite hydrogel and a preparation method and application thereof, the composite hydrogel comprises a hydrogel matrix and functional components dispersed in the hydrogel matrix, and the functional components comprise anti-MoSe2 nano-enzyme and selenium-rich probiotics wrapped by an antioxidant film. According to the MoSe2 nano-enzyme-selenium-enriched probiotic composite hydrogel provided by the invention, the sonodynamic characteristics of the MoSe2 nano-enzyme and the biological activity of the selenium-enriched probiotics are perfectly fused: under ultrasonic stimulation, the MoSe2 nano-enzyme not only can directly and efficiently generate reactive oxygen species (ROS), but also can catalyze low-concentration hydrogen peroxide to generate a large amount of hydroxyl radicals (. OH); broad-spectrum killing of various pathogenic bacteria is achieved, and the risk of drug resistance evolution of bacteria is reduced from the source; meanwhile, antibiotics secreted by the selenium-enriched probiotics can form a synergistic sterilization effect, so that the pathogenic bacterium removal effect is further enhanced.

The invention relates to the technical field of biological materials, and discloses electrical stimulation LDH hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a zinc salt, a vanadium salt and urea in water in a nitrogen atmosphere to obtain a precursor solution; the precursor solution is subjected to a hydrothermal reaction, and ZnV-LDH is obtained; under stirring, gradually dropwise adding methacrylic anhydride into the gelatin solution, and heating for reaction; adding preheated water into the reaction liquid to stop the reaction; dialyzing and purifying the reaction liquid, pre-freezing, and freeze-drying to obtain hydrogel; and adding ZnV-LDH into the hydrogel, and carrying out ultrasonic mixing, so as to obtain the electrical stimulation LDH hydrogel. Through the synergistic effect of the ZnV-LDH and the hydrogel, the electrical stimulation LDH hydrogel disclosed by the invention has electrical activity and can generate potential change in response to external stimulation; under ultrasonic stimulation, concentration-dependent electrical response can be generated, the response has periodicity and stability, and osteogenic differentiation and cell mechanical properties can be promoted to the maximum extent.

A biomimetic intervertebral fusion device with a piezoelectric multifunctional coating belongs to the field of implantable medical devices. It includes an upper piezoelectric multifunctional coating, a fusion device body, and a lower piezoelectric multifunctional coating. A bone graft window is located in the middle of the biomimetic intervertebral fusion device. The piezoelectric multifunctional coating is made of electrospun piezoelectric PVDF / HA fibers, which are conformally adhered to the upper and lower surfaces of the fusion device body through a polydopamine adhesive layer. The upper and lower surfaces of the fusion device body have a biomimetic curved surface configuration to match the morphology of the vertebral endplates, increasing the contact area and reducing stress concentration at the fusion interface. While maintaining an elastic modulus similar to natural bone and good radiation permeability, this fusion device, after implantation, can create a microenvironment conducive to cell adhesion and proliferation. Under the influence of cell traction, ultrasonic stimulation, and the physiological load of the human lumbar spine, it generates electrical stimulation signals, promoting bone fusion, improving the stability of the fusion interface, and reducing the risk of postoperative loosening and subsidence of the fusion device.

The utility model relates to the technical field of oral treatment, and discloses ultrasonic tooth orthodontic auxiliary treatment equipment and an oral treatment device, a denture base body is provided with a treatment part which can be selectively attached to gingiva, tooth covering grooves with different sizes can be formed by fitting gum shapes of different patients, the treatment part can be recycled, and the treatment effect is good. The universality of the ultrasonic tooth orthodontic auxiliary treatment equipment is improved, the treatment cost is reduced, the fit degree of the treatment part and the periodontium is higher, and the orthodontic auxiliary treatment effect is stabilized; the flexible circuit board is arranged in the treatment part and deforms together with the treatment part, conductor wiring used for transmitting electric energy is arranged in the flexible circuit board to integrate circuits, additional wiring is not needed, and wiring harness arrangement is neat; the ultrasonic transduction sheets which are in one-to-one correspondence with the teeth to be orthodontic and are arranged opposite to the gingiva are arranged in the treatment part and are electrically connected with the conductor wiring at the same time, assembly is simple, the ultrasonic transduction sheets are conveniently arranged in the oral cavity of a patient, ultrasonic stimulation is carried out on targeted parts of the teeth, and the orthodontic effect is improved.

The invention belongs to the technical field of medicines, and relates to injectable piezoelectric hydrogel for a spinal cord injury part as well as a preparation method and application of the injectable piezoelectric hydrogel. According to the hydrogel, methacrylated gelatin is used as a carrier, and a piezoelectric material MOF (at) PDA (at) M0, namely MP (at) M, of an enveloping porous structure is loaded in the hydrogel. The hydrogel can achieve dual functions under the ultrasonic action: (1) MP (at) M has piezoelectricity, ultrasonic mechanical energy is converted into electrical stimulation, calcium ion inward flow of astrocytes is triggered, mitochondria is promoted to be transferred from the astrocytes to neurons, and the mitochondrial function of the neurons is recovered; (2) the CD73 enzyme carried by the microglial cell membrane coated on the surface of the MP (at) M can degrade pro-inflammatory ATP (adenosine triphosphate) at the damaged part to generate adenosine, so that astrocytes are promoted to release lactic acid, and rapid energy support is provided for neurons. Mitochondrial transfer and energy supply are synchronously promoted through ultrasonic stimulation, neuronal plasticity is remodeled, spinal cord axon regeneration is promoted, and a new strategy is provided for spinal cord injury treatment.

The invention relates to the technical field of medical data processing and three-dimensional modeling, and discloses a skull thickness distribution diagram construction method and system fusing ultrasonic thickness measurement and optical localization. According to the method, an ultrasonic probe is used for obtaining a skull thickness value at a measuring point of the scalp of a subject, and meanwhile, a three-dimensional space coordinate of the measuring point is accurately determined through an optical navigation positioning system. The system binds the thickness value and the space coordinates in real time to form thickness-space data points, and performs multi-point repeated acquisition on the scalp surface, thereby constructing a three-dimensional thickness point cloud. And finally, the upper computer system performs interpolation processing on the point cloud data to generate a skull thickness distribution diagram with spatial continuity. According to the method, the defect that the skull thickness data and the anatomical space positioning information are mutually independent is overcome, accurate space-time correspondence of the measured value and the space position is realized, an individualized skull model can be constructed quickly at low cost, and an accurate sound field compensation calculation basis is provided for applications such as transcranial ultrasonic stimulation.

The present application relates to the technical field of biological cell culture, and particularly relates to a fixed bed device and method for improving secretion and expression of exosomes. The device comprises a fixed bed reactor, an ultrasonic generator, a connecting flange and a control unit. The ultrasonic generator is installed on the top of the fixed bed reactor through the connecting flange. The control unit is configured to control the ultrasonic generator to apply ultrasonic stimulation to the cells intermittently in the whole cycle of cell culture. The ultrasonic intensity is dynamically regulated in three stages according to the culture cycle. The present application uses pure physical stimulation without adding chemical reagents. Under the premise of maintaining normal growth and activity of cells, the yield of exosomes can be increased by more than 169%. The present application is suitable for animal cells and plant cells and has a wide industrial application prospect. The technical problems of low yield of exosomes, stimulation mode that may affect cell activity or introduction of chemical reagents that may interfere in the prior art can be effectively solved.

The application relates to application of a piezoelectric material in preparation of a medicine for treating gout, characterized in that a medicine active ingredient of the medicine comprises the piezoelectric material, the piezoelectric material is barium titanate; the application comprises the following steps: delivering the medicine to a lesion site, applying ultrasonic stimulation to the lesion site, and exciting in-vivo active species degradation of uric acid by the medicine. The piezoelectric material has good piezoelectric catalytic performance, excellent tissue penetration ability, low toxicity and high precision, active species can be controllably excited by means of ultrasonic action at the time of gout attack, uric acid can be efficiently degraded into allantoin which is good in solubility and non-toxic, symptoms can be rapidly relieved, the piezoelectric material can be long-term resident in joints, can keep stable catalytic effect in multiple cycles, and long-term treatment of gout can be realized by single injection, and a new gout treatment scheme which is more effective and more durable is provided.

1. Name of the product in this design: Neck stimulator. 2. Purpose of this design: A stimulator for ultrasonic stimulation of cervical nerves. 3. The key design feature of this product is its shape. 4. The picture or photo that best illustrates the key design points: Design 1 3D diagram 1. 5. Design 1 is designated as the basic design.

A beauty device using skin impedance measurement and ultrasonic cross-frequency according to an embodiment of the present invention comprises: an electrical stimulator including an electrode, which transmits a current to the skin of a subject in order to measure the skin impedance of the subject and care for the skin condition of the subject analyzed on the basis of the skin impedance of the subject, and an LED, which irradiates the skin of the subject with light while the current is being transmitted to the skin of the subject; and a cross-frequency ultrasonic stimulator that measures the skin impedance of the subject and is provided with an ultrasonic generator that irradiates the skin of the subject with ultrasonic waves of cross-frequency in order to care for the skin condition of the subject analyzed on the basis of the skin impedance of the subject, wherein the beauty device can apply electrical stimulation, optical stimulation, and ultrasonic stimulation to the skin of the subject.

SLA-based additive manufacturing using radiation-curable foams enables the production by 3D printing of lightweight parts having desirable physical and functional attributes. A representative method of manufacturing such items includes processing a radiation-curable resin in liquid form to produce a stable, non-aqueous radiation-curable foam, on-demand deposition of the foam at a build layer of a build surface within a 3D printer, and then curing the non-aqueous radiation-curable foam to produce a layer of a 3D build item. Processing the resin typically includes agitation, mixing, shaking, gas injection, ultrasonic stimulation, or combinations thereof. 3D articles of manufacture made by the above-described manufacturing process are also provided.

To solve the problem that a patient cannot be treated or treatment efficiency is reduced due to discomfort and stress to a burn based on heat generation of a probe.SOLUTION: An ultrasonic stimulation apparatus including a main body unit, a probe that outputs an ultrasonic wave oscillated by an ultrasonic transducer through a cover in which the ultrasonic transducer is disposed, and an electric floor pad that supplies negative charges, in which the main body unit includes an electric signal generation unit that outputs an ultrasonic wave supply electric signal, a negative charge circuit unit that outputs a negative charge supply electric signal, and a control unit that controls the electric signal generation unit and the negative charge circuit unit, and the electric signal generation unit can output a first electric signal of a first frequency and a second electric signal of a second frequency, the control unit controls output of the second electric signal and the negative charge supply electric signal on the basis of information indicating that a current of the first electric signal exceeds or falls below a threshold.SELECTED DRAWING: Figure 1

The invention relates to the field of biological medicine, in particular to a retina organ with a vision improving function and a preparation method and application thereof. According to the method, the bottleneck in the prior art is broken through through innovative integration of low-intensity ultrasonic stimulation and a retina organoid technology, the advantages of efficiently accelerating differentiation and maturation of the photoreceptor and improving the differentiation efficiency of the photoreceptor are achieved, meanwhile, the bottleneck of transplantation integration is broken through, survival and integration of the graft are improved, and the purpose of recovering vision is achieved. In conclusion, the retina organoid culture method capable of promoting differentiation of the photoreceptor through ultrasonic stimulation is constructed for the first time, and a new view angle can be provided for research on treatment of retina degenerative diseases. Meanwhile, the core bottlenecks of insufficient photoreceptor differentiation and low transplantation integration rate of the retinal organ are solved, the retinal organ subjected to low-intensity ultrasonic stimulation can be used as a high-quality graft source, and a novel treatment strategy is provided for retinal degenerative diseases.

This invention provides an antibacterial and repair-promoting piezoelectric film, its preparation method, and its application, belonging to the field of piezoelectric material technology. The method involves in-situ self-assembly of Fe-MOF on the surface of BTO, followed by further loading with DHA to synthesize an electrically controlled drug-release, antibacterial, and repair-promoting nanocomposite, BTO / Fe-MOF / DHA. BTO / Fe-MOF / DHA is then added to the surface of semi-cured PDMS to form an antibacterial and repair-promoting piezoelectric film, PDMS-BTO / Fe-MOF / DHA. When the PDMS-BTO / Fe-MOF / DHA piezoelectric film is subjected to ultrasonic stimulation, BTO converts mechanical energy into electrical energy, releasing Fe from the Fe-MOF... 3+ Reduced to Fe 2+ Fe-MOF degrades and releases DHA, and ultimately, Fe... 2+ Reacting with synchronously released DHA, it produces a large amount of toxic ROS, which damages proteins and nucleic acids, inducing bacterial death. The antibacterial and repair-promoting piezoelectric membrane of the present invention generates a piezoelectric potential during mechanical deformation caused by animal movement and induces EF at the wound site to promote wound healing. This antibacterial and repair-promoting piezoelectric membrane shows great potential in the future treatment of bacterial infected wounds.

The application discloses a kind of attenuated salmonella load adjuvant nano combination medicine, the combination medicine is modified to bacterial surface by means of amino and carboxyl condensation reaction, adamantane is simultaneously modified to adjuvant nano medicine surface using diselenium dynamic bond, then the host-guest interaction of adamantane and cyclodextrin is used to assemble two, and then nano medicine is stably combined on the surface of attenuated salmonella.Diselenium dynamic bond can be broken by ultrasound response, so as to realize the effect of drug release.This combination medicine has the tumor targeting enrichment ability of bacteria and the release characteristics of adjuvant nanoparticles under the action of ultrasonic wave, can realize targeted delivery and deep penetration in tumor tissue, and obtain significant tumor inhibition effect under ultrasonic stimulation.The experimental results show that the combination medicine exhibits good therapeutic effect in inhibiting tumor growth, and has excellent biological safety.

The application relates to an ultrasonic stimulation desynchronization simulation method, system and device based on a double-neuron model. The method comprises the following steps: acquiring ultrasonic wave data, wherein the ultrasonic wave data comprises sound pressure and / or frequency; inputting the ultrasonic wave data into an intramembranous cavitation model constructed based on an intramembranous cavitation effect to obtain an intramembranous capacitive displacement current; inputting the obtained intramembranous capacitive displacement current into a double-neuron model to obtain time corresponding to the peak values of two neuron potentials; calculating a phase difference according to the time corresponding to the peak values of the two neuron potentials; and obtaining that the two neurons are in a desynchronized state or a synchronized state according to the phase difference. The method aims to realize desynchronization based on ultrasonic stimulation simulation of the double-neuron model, and to explore the inhibition capacity and potential application value of the double-neuron model on morbid attacks.

The invention belongs to the technical field of animal model construction, and discloses a construction method and application of a mouse encephaledema model. The construction method of the encephaledema model is simple and convenient to operate, simple and easy to repeat, stable in injury, high in success rate and low in death rate, and the encephaledema model can be obtained only by applying 0.4-0.6 W ultrasonic stimulation to the brain of an animal. Parameters can be adjusted according to actual needs, so that the damage degree is changed, the research purpose is met, and high controllability is achieved. The construction method provides a new research model for in-vivo research of the occurrence and development process and mechanism of encephaledema.

The application relates to the technical field of biomedical materials, and particularly discloses an injection piezoelectric hydrogel with enhanced heterojunction and a preparation method and application thereof. The hydrogel is composed of 45% to 75% of polyvinyl alcohol, 3% to 15% of sodium carboxymethyl cellulose, 3% to 15% of gelatin, 1% to 10% of a zinc oxide / zinc sulfide heterojunction nano phase, 2% to 15% of magnesium chloride and 5% to 35% of trisodium citrate. The zinc oxide / zinc sulfide heterojunction nano phase is prepared through hydrothermal synthesis and chemical vapor deposition calcination. The interface type II band and the built-in electric field are used to drive charge separation, and the piezoelectric response is enhanced through oxygen vacancies. Compared with the prior art, the hydrogel prepared by the application has high wet-state ionic conductivity, injectability and morphological stability. Under ultrasonic stimulation, the piezoelectric signal output reaches 150 mV, and the hydrogel is suitable for repairing infectious bone defects such as periodontitis, and can promote osteogenic differentiation and microenvironment regulation in cooperation with ion release.

The invention discloses an ear clip type ultrasonic vagus nerve regulation and control device and a control method thereof, and belongs to the technical field of biomedical engineering and wearable equipment. The device adopts a shell assembly imitating a TWS earphone, and an ultrasonic transducer, a driving circuit module, an optical auxiliary positioning module, a monitoring module, a control module and the like are highly integrated in the shell assembly. The method is characterized in that a system unlocks ultrasonic stimulation only when an optical positioning result is confirmed to be valid by a user, so that the accuracy of a target spot is ensured; in the stimulation process, automatic safety protection is executed by monitoring the temperature and the contact state in real time. According to the control method, subjective feedback and objective monitoring data of a user are fused, and personalized self-adaptive adjustment of stimulation parameters is achieved. The problems that traditional equipment is heavy, inaccurate in positioning and lack of intelligent safety control are solved, and an accurate, safe and comfortable ultrasonic nerve regulation and control solution capable of being worn daily is provided.

A method for stimulating hydrogen production (200) from an injected formation (102). The method includes the step of providing a well system (106) through a subterranean formation (104) into an injected formation (102) containing hydrocarbons. Carbon dioxide, water, steam, and combustion gases are introduced into the injection formation (102) via a well system (106). Further, one or more of infrasonic, acoustic, and ultrasonic stimulation (225) is used to stimulate the injected formation (102). The injected formation (102) is monitored (230) via one or more sensors located in the injected formation (102) to determine one or more properties of the reaction and backflow effluent in the injected formation (102). A reflux operation (240) is performed to recover a reflux effluent.

The application relates to the technical field of Fresnel acoustic lens application, and provides a composite Fresnel acoustic lens, a design method and related equipment. The composite Fresnel acoustic lens comprises at least two groups of coaxial multi-focus Fresnel zone plates, the at least two groups of coaxial multi-focus Fresnel zone plates are stacked after being radially translated by a set distance, at least three non-coaxial ultrasonic focal points are generated in a three-dimensional space, and the composite Fresnel acoustic lens can be used for transcranial ultrasonic stimulation or treatment; wherein the coaxial multi-focus Fresnel zone plate comprises a multi-layer lens structure which is nested together, and the multi-layer lens structure comprises a frame area and an ultrasonic transmission medium area. The method of stacking multiple groups of coaxial multi-focus Fresnel zone plates is used to simultaneously focus multiple different-axis and different-depth ultrasonic target points, and the limitation of a limited coverage range of a traditional single-focus or coaxial double-focus is overcome.

The invention provides a multi-channel ultrasonic-driven wound treatment and healing prediction device. The multi-channel ultrasonic-driven wound treatment and healing prediction device is characterized in that a multi-channel configurable ultrasonic stimulation module, a broadband biological impedance measurement module and a processing module are integrated on a single portable device; secondly, based on a high-voltage shift register, a specific method of grouping any two channels and alternately outputting high-voltage pulses to drive a piezoelectric transducer is realized, and flexible and collaborative ultrasonic stimulation is realized; and finally, predicting a healing stage through the impedance signal, and automatically adjusting ultrasonic treatment output parameters according to a prediction result. Therefore, the system has the functions of impedance monitoring and ultrasonic treatment at the same time, the treatment strategy can be dynamically optimized in real time according to the monitoring result, dynamic parameter adjustment of wound treatment, real-time non-invasive monitoring of the healing stage and intelligent closed-loop control of treatment and monitoring can be achieved, and therefore the wound healing effect and treatment convenience are improved.

The invention discloses a preparation method and application of IBFO (at) high-entropy alloy heterojunction piezoelectric hydrogel (IBHA-SAPS), and the preparation method comprises the following steps: preparing high-entropy alloy (HEA) powder through sol-gel and calcination, compounding the HEA powder with bismuth-doped bismuth ferrite (IBFO) to construct an IBFO (at) HEA heterojunction (IBHA), and finally carrying out cross-linking molding with a sodium alginate-phenylboronic acid polymer. Under ultrasonic stimulation, the piezoelectric effect of the hydrogel can synergistically enhance the sonodynamic performance and the nano-enzyme activity, and in an acidic microenvironment, efficient antibiosis and biological membrane removal can be achieved through high-intensity ultrasound; in a neutral physiological microenvironment, low-intensity ultrasound can trigger the composite material to remove active oxygen so as to relieve oxidative stress and generate an electric signal to promote osteoblast differentiation, and the composite material has good biocompatibility, injectability and intelligent responsiveness and has wide application prospects in the fields of sonodynamic therapy, tissue engineering scaffolds, infectious bone defect repair and the like.

The invention discloses a sonodynamic nano-catalyst and a preparation method and application thereof.The preparation method constructs an organic metal molecule with copper as the center, the organic metal molecule adopts an acceptor-donor-acceptor (A-D-A) structural design, and after the organic metal molecule is prepared into nano-particles, active oxygen can be efficiently generated under ultrasonic stimulation. In order to enhance tumor targeting and immune regulation functions, the sonodynamic nano-catalyst is wrapped to overexpress M1 type macrophage membrane of PD-1, and the sonodynamic nano-catalyst and lipid nanoparticles entrapped and loaded with targeted CD300ld small interfering RNA are jointly loaded into 3D printed bioadhesive GelMA-based hydrogel, so that precise implantation of the cervix uteri is realized. After ultrasonic activation, the system realizes tumor killing ROS generation and selective silencing of PMN-MDSC source immunosuppression.

The application discloses a hydrogel device and method for oral pH detection and sonodynamic therapy. The device comprises a hydrogel packaging layer and a pH sensing coupled sonodynamic therapy module; the hydrogel packaging layer is formed by two layers of network crosslinking, the first layer of network acts as a rigid but fragile skeleton, and the second layer of network is soft and stretchable, so that the hydrogel device has excellent mechanical properties and deformation ability; the pH sensing coupled sonodynamic therapy module is a wrapped structure, the outside is used for pH sensing, and reflects the caries damage condition of the oral cavity; the inside of the pH sensing coupled sonodynamic therapy module is a sonodynamic therapy module, which is used for generating active oxygen under ultrasonic stimulation, realizes the double effect of disinfection and tooth whitening on oral cariogenic bacteria, and the method provides an instant detection and nursing platform for oral health condition, and has the advantages of adhesion type, customizability, in-situ sensing and non-invasive treatment.

This invention discloses a bismuth-copper bimetallic coordination nanomaterial, its preparation method, and its applications, belonging to the technical field of biofunctional materials. The prepared bismuth-copper bimetallic coordination nanomaterial can efficiently generate reactive oxygen species (ROS) under ultrasonic stimulation, initiating the sonodynamic therapy (SDT) process; the Cu in this material... 2+ The weakly acidic environment of the tumor microenvironment can also trigger a Fenton-like reaction, generating cytotoxic hydroxyl radicals (•OH) and oxygen in situ, thus initiating the chemokinetic therapy (CDT) process. Through the synergistic effect of sonodynamic therapy (SDT) and chemokinetic therapy (CDT), they jointly inhibit cancer cell proliferation and promote T cell generation.

A system for noninvasive neuromodulation of brain regions is provided. The system includes, one or more ultrasound transducers configured to deliver ultrasonic stimulation energy to an intended deep brain region and a transcranial magnetic stimulation (TMS) coil configured to deliver magnetic stimulation energy to an intended superficial cortical region. The system is configured to deliver the ultrasonic stimulation to a deep brain region and the magnetic stimulation to a superficial brain region. The intended deep brain region and intended superficial cortical region are a pairing corresponding to a neurological or psychological disorder.