156 results about "Ultrasonic stimulation" patented technology

The invention relates to the technical field of data analysis and processing, and discloses a sleep-awakening circadian rhythm disorder adjusting method and device based on ultrasonic stimulation. The method comprises the following steps: collecting sleep physiological data of a user to construct a feature matrix; analyzing a sleep stage to obtain a disorder type; generating an ultrasonic stimulation parameter scheme; determining brain region stimulation coordinates to generate spatial positioning data; predicting user feedback through the convolutional neural network; and comparing the prediction and actual feedback adjustment schemes to obtain an optimized target stimulation scheme. According to the method and the device, accurate recognition, personalized stimulation parameter generation, accurate brain region positioning, predictive evaluation and dynamic scheme optimization of sleep-awakening circadian rhythm disorders are realized, so that the regulation effect of ultrasonic stimulation on various sleep-awakening circadian rhythm disorders is improved.

The invention relates to the technical field of nerve probes, and provides a four-mode integrated nerve probe and a preparation method thereof. The four-mode integrated nerve probe provided by the invention comprises a flexible substrate, an electric signal recording module, an ultrasonic stimulation module, a light stimulation module and a microfluidic channel. The electric signal recording module is used for recording electroneurographic signals, the ultrasonic stimulation module is used for ultrasonic stimulation, the optical stimulation module is used for optical stimulation and signal recording, and the microfluidic channel is filled with drugs through a microfluidic channel control port in the probe body and releases the drugs through a microfluidic channel outlet in the needle tip. According to the four-mode integrated nerve probe provided by the invention, multiple functions are integrated into one probe, so that comprehensive detection and regulation of a nervous system are realized, and the technical problems that a traditional nerve probe is single in function, inflammation is caused by a rigid material and multi-mode integration is insufficient are solved.

The invention provides a scalp brain signal acquisition method and system, a medium and electronic equipment, and relates to the technical field of brain-computer interfaces. The scalp brain signal acquisition method comprises the following steps: determining excitation signal parameters of FUS according to head acoustic parameters; the excitation signal parameters are used for enabling the irradiation focus of focused ultrasound FUS of the ultrasonic phase control transducer to be located on the scalp contour; in response to the ultrasonic stimulation instruction, controlling the ultrasonic phased transducer to generate an array element excitation signal based on the excitation signal parameter so as to perform ultrasonic irradiation on the irradiation focus; and in response to the electroencephalogram acquisition instruction, acquiring an electroencephalogram signal to obtain a focused ultrasound modulated scalp electroencephalogram signal. According to the method, the accuracy of the scalp electroencephalogram signals can be improved.

Disclosed are devices, systems, and methods for ultrasonically stimulating brain tissue using operating parameters associated with a. target region of a brain. The operating parameters can be determined, for example, by combined ultrasonic stimulation and photometry devices and methods. The operating parameters can include pulse repetition frequency, temporal compression, and intensity. Using selected operating parameters, ultrasound stimulation of the target region of the brain can excite or inhibit brain cell activity.

The invention provides an ultrasonic activated azido precursor, a prodrug and application. The precursor and an active drug react and are bonded to obtain the azido prodrug; the bonding group of the active medicine is amino, hydroxyl or sulfydryl; a bonding group of the ultrasonic activated azido precursor is an ester group. Novel ultrasonic activatable groups, namely p-azidobenzyloxycarbonyl and derivatives thereof, are adopted, hydrogen atoms on a benzene ring are substituted to different degrees, the reducing capacity of a precursor can be remarkably improved, azide is effectively reduced into amino through ultrasonic stimulation under the action of TBR and NADH, and then a self-elimination reaction is induced to release active drugs. The structure has the advantages that different types of active drugs (active pharmacodynamic groups can be amino, hydroxyl and sulfydryl) can be bonded through 4-nitrophenyl carbonate, high-selectivity reduction is performed under the triple action of ultrasound, TBR and NADH, active raw drugs are released according to needs, and toxicity reduction and synergism are achieved.

The utility model discloses an ultrasonic wearing device for tooth orthodontics, which comprises a U-shaped seat and a plurality of supports arranged on the U-shaped seat, each support is of a U-shaped structure, a corresponding ultrasonic transducer is arranged on each support, the plurality of ultrasonic transducers correspond to the corrected teeth of a patient in number and position, and the plurality of ultrasonic transducers are arranged on the U-shaped seat. The ultrasonic transducer is used for performing ultrasonic stimulation on the tooth root. According to the utility model, the arrangement direction of the conductor on the bracket is matched with the opening direction of the sliding groove, the bracket is inserted into the sliding groove through the conductor, and then the bracket is rotated by 90 degrees, so that the two ends of the conductor are inserted into the conduction end, a damping effect on the conductor is achieved, and the bracket is more convenient to disassemble and assemble; the support can be mounted or dismounted only by rotating the support by 90 degrees to enable the extending direction of the conductor to correspond to the forming direction of the sliding groove, and due to the fact that the ultrasonic transducer is arranged on the support, replacement of the ultrasonic transducer in the later period is more convenient.

The invention discloses stimuli-responsive cross-linked polyamide and a preparation method and a stimuli-responsive method thereof, and relates to the technical field of polymer synthesis, and the preparation method of the cross-linked polyamide comprises the following steps: heating linear furyl polyamide and a cross-linking agent in a solvent B for reaction to prepare the cross-linked polyamide. The stimuli-responsive crosslinked polyamide is excellent in comprehensive performance, the stimuli-responsive mode is simple, the preparation method is green and convenient, the polyamide is synthesized through a one-pot method, the crosslinked polyamide is synthesized through a DA reaction, and the thermal property and the mechanical property are excellent; in addition, reversible crosslinking occurs under ultrasonic stimulation response, and the thermal performance and the mechanical performance of polyamide can be controllably adjusted. The polyamide performance controllable adjustment method provided by the invention expands the application of polyamide in the fields of biomedical treatment and the like.

The invention relates to a method for promoting nerve cell proliferation and differentiation based on ultrasonic stimulation and application, and belongs to the technical field of biomedicine. According to the method, under the conditions that the power is 90-110 mW and the frequency is 0.9-1.1 MHz, nerve cells are continuously stimulated for 3 days by ultrasonic waves once per day, and each time lasts for 2-4 min. The purposes of increasing the nerve cell proliferation speed and promoting nerve cell differentiation are achieved only through ultrasonic stimulation under specific conditions for the first time, no other substances are added, non-invasion and non-contact are achieved, and toxic and side effects on cells are low; the nerve cells are not subjected to invasive or modified operation; the method has a wide application prospect only through physical conditions.

The invention relates to a closed-loop transcranial acoustic-magnetic stimulation neural circuit regulation and control system and method, and the system comprises an individualized simulation navigation module which is used for carrying out the simulation navigation of ultrasonic stimulation and magnetic stimulation on a brain region of a regulation and control object, and obtaining a stimulation site; the transcranial ultrasonic stimulation module is used for outputting ultrasonic stimulation by adopting the initialized stimulation parameters according to the stimulation sites and carrying out transcranial ultrasonic stimulation on the regulation and control object; the transcranial magnetic stimulation module is used for outputting magnetic stimulation by adopting the initialized stimulation parameters according to the stimulation sites and carrying out transcranial magnetic stimulation on the regulation and control object; and the electroencephalogram collecting, processing and feedback module is used for synchronously collecting and analyzing electroencephalogram signals in the acoustic and magnetic combined stimulation process and optimizing stimulation parameters. According to the method, high spatial resolution of transcranial ultrasonic stimulation, flexibility of transcranial magnetic stimulation and real-time processing of electroencephalogram data are combined, and accurate individualized neural circuit regulation and control are achieved.

The invention discloses an ear acupoint closed-loop ultrasonic stimulation system and method based on sleep electroencephalogram signal feedback, and belongs to the technical field of ultrasonic stimulation nerve regulation and control. The ear acupoint closed-loop ultrasonic stimulation system comprises an electroencephalogram acquisition module, a regulation and control module, an ultrasonic transmitting module and a dynamic association module; the electroencephalogram acquisition module is used for acquiring electroencephalogram signals within limited time specified by a user according to specified sampling frequency, amplifying and filtering the acquired signals and sending the processed signals to the regulation and control module; the regulation and control module judges the current sleep stage of the user, drives the ultrasonic transmitting module, performs variable parameter closed-loop ultrasonic stimulation on the user, and automatically adjusts stimulation parameters and duration according to the current sleep stage; and the dynamic association module sets a multi-threshold triggering mechanism based on the real-time electroencephalogram characteristic parameters and discriminates a specific physiological status. According to the invention, accurate acupoint stimulation can be realized, a real-time feedback mechanism is provided, and the accuracy and effectiveness of stimulation can be ensured.

The invention discloses a transcranial ultrasonic stimulation device and a focal length adjusting method, and relates to the technical field of medical instruments and ultrasonic therapy. The screwing assembly is arranged on the outer side of the bottom of the ultrasonic transducer, and the ultrasonic transducer is rapidly disassembled and assembled through the screwing assembly; and the ultrasonic coupling assembly is arranged at the bottom of the screwing assembly and is matched with the ultrasonic transducer, and the ultrasonic coupling assembly is used for reducing air gaps during fitting so as to reduce the sound energy loss. Through the cooperative arrangement of the ultrasonic transducer, the screwing assembly and the ultrasonic coupling assembly, accurate ultrasonic conduction can be achieved, the device can adapt to a complex head shape, especially in complex target spots such as binaural areas, the flexible characteristic of the soft bag ensures that the soft bag is tightly attached to the head tissue, and the effect that the soft bag is tightly attached to the head tissue is achieved. Consistent sound wave conduction can be provided, interference of air or other substances is avoided, and the treatment effect is remarkably improved.

The invention relates to the technical field of laser ultrasound, and particularly discloses a multi-dominant-frequency laser ultrasonic holographic system and a design method.The system comprises a laser and a laser beam adjusting module used for receiving and adjusting laser beams, the laser beam adjusting module comprises a beam expanding lens and a collimating lens which are coaxially arranged, the beam expanding lens is used for adjusting the diameter of the laser beams, and the collimating lens is used for adjusting the diameter of the laser beams; the collimating mirror is used for collimating the laser beams so that the laser beams are kept parallel and focused; the frequency mixing ultrasonic holographic lens comprises a light focusing layer, a sound restraint layer, a light absorption layer, a sound matching layer and a sound holographic layer which are stacked in sequence, and the frequency mixing ultrasonic holographic lens is used for receiving the laser beams passing through the laser beam adjusting module so as to generate multiple stable single or multiple focusing ultrasonic sound fields with different preset frequencies in a time-sharing or simultaneous manner; and the focusing focus position and power can be adjusted, so that the device can be used for ultrasonic control and driving, ultrasonic detection imaging, low-power ultrasonic stimulation or power ultrasonic treatment and the like.

The invention relates to the field of biological medicine, and discloses multifunctional nano hydrogel as well as a preparation method and application thereof. The multifunctional nano hydrogel is prepared from the following raw materials: glutathione modified silk protein, metacrylic acid esterified pectin and an MXene coated TiO2 nanosheet. According to the multifunctional MXene-coated TiO2 biological heterojunction hydrogel provided by the invention, space-time controllable antibacterial treatment and enhanced tissue regeneration are realized through dynamic ROS (reactive oxygen species) adjustment triggered by ultrasonic waves. The hydrogel can rapidly kill bacteria under ultrasonic stimulation, meanwhile, excessive ROS is removed after ultrasound is stopped, and the double challenges of oxidative stress and tissue regeneration are effectively solved.

The invention discloses a self-adaptive closed-loop ultrasonic stimulation system and method based on Actor-Critic reinforcement learning, and belongs to the field of neural regulation and control technologies and biomedical engineering, and the system comprises a signal collection module, a preprocessing module, an Actor strategy module, a Critic value module, an ultrasonic stimulation module, a safety monitoring module and a storage module. The Actor strategy module generates safe and controllable ultrasonic stimulation parameters according to the preprocessed electroencephalogram data; the safety monitoring module is used for checking whether the ultrasonic stimulation parameters generated by the Actor module meet safety standards or not; the ultrasonic stimulation module sends out an ultrasonic stimulation signal according to the ultrasonic stimulation parameter; and the Critic value module evaluates the electroencephalogram feedback effect after ultrasonic stimulation and provides feedback to the Actor module for optimizing the experimental strategy of the next step. The invention aims to intelligently adjust the ultrasonic stimulation parameters through the biofeedback data monitored in real time in combination with the reinforcement learning algorithm.

The invention discloses a multifunctional transcranial therapeutic apparatus and a control method thereof. The transcranial therapeutic apparatus relates to the field of medical equipment and solves the problem of single function of a traditional transcranial therapeutic apparatus. The transcranial electrical stimulation module can transmit direct current stimulation or alternating current stimulation; the transcranial magnetic stimulation module can provide a pulsed magnetic field; the ultrasonic stimulation module generates ultrasonic waves through an ultrasonic transducer. The multiple stimulation heads are used for being distributed in different areas of the head, an electrical stimulation electrode slice of the transcranial electrical stimulation module, a magnetic stimulation coil of the transcranial magnetic stimulation module and an ultrasonic transducer of the ultrasonic stimulation module are integrated in each stimulation head, and signal generators of all the modules are controlled in a unified mode through the main controller. A single stimulation mode or combined work of multiple stimulation modes is selected according to the illness state and treatment requirements of a patient, the different stimulation combination modes synergistically act on a target brain area, the treatment effect is improved, and the problems that a traditional transcranial therapeutic apparatus only supports a single stimulation mode and is poor in treatment effect are solved.

The preparation method comprises the following steps: by taking an oriented polylactic acid nanofiber membrane as a raw material, carrying out homogenization treatment to obtain polylactic acid piezoelectric short fibers; gelMA is used as a skeleton matrix, polylactic acid short fibers, LAP and DRG cells are compounded, a 0 / 90-degree alternate grid structure scaffold is constructed through pneumatic extrusion type biological printing, and the dual-network piezoelectric biological scaffold is formed through blue light crosslinking curing. The piezoelectric effect of polylactic acid short fibers is activated through ultrasonic stimulation, mechanical energy is converted into local electric signals, loaded DRG cells are directly driven to secrete CGRP in situ, macrophages are dynamically regulated and controlled to be polarized to M2 anti-inflammatory phenotypes, nerve-immune microenvironment disorder of diabetic bone defects is corrected, vascularization and bone regeneration are promoted, and the diabetic bone defect treatment effect is improved. The problems of short delivery half-life period of traditional cell factors, difficulty in nerve function reconstruction and chronic inflammation caused by non-degradable piezoelectric materials are solved, and non-invasive and degradable precise bone repair is realized.

The invention relates to the technical field of ultrasonic medical instruments, and discloses a wide-area closed-loop control transcranial ultrasonic stimulation system, which comprises an ultrasonic circuit and an ultrasonic transducer, and is characterized in that the ultrasonic circuit is composed of a power supply, a main control circuit, an ultrasonic driving circuit, a matching circuit and a sampling circuit; the power supply is used for adjusting a direct-current input voltage value of the ultrasonic driving circuit according to a control signal of the main control circuit; the matching circuit is used for adjusting a matching inductance value connected in series into the circuit; the sampling circuit is used for sampling and measuring the direct-current input voltage value of the ultrasonic driving circuit and the output voltage applied to the two ends of the ultrasonic transducer. According to the transcranial ultrasonic stimulation system, the output of the ultrasonic transducer can be adjusted in a wide sound intensity range, so that the system can adapt to more application scenes; and meanwhile, the required sound intensity is automatically adjusted by adopting a closed-loop algorithm, so that preset parameters are reduced, the adaptability of an ultrasonic circuit and an ultrasonic transducer is wider, and the use cost is lower.

The invention relates to the field of treatment ultrasound, in particular to a heart rate regulation and control system based on focused ultrasound and application of the heart rate regulation and control system. The heart rate regulation and control system based on focused ultrasound comprises an ultrasonic stimulation module, a central control module and an electrocardiosignal acquisition module, the ultrasonic stimulation module is in communication connection with the central control module, and the electrocardiosignal acquisition module is in communication connection with the central control module. The heart rate regulation and control system based on focused ultrasound provided by the invention is controlled by the multi-degree-of-freedom mobile platform to noninvasively convey ultrasonic energy to a heart target region, so that the following effects are achieved: 1) the heart rate can be noninvasively and safely regulated; 2) the system is simple to operate; 3) the heart rate regulation and control effect is high in real-time performance; and 4) the heart rate regulation and control effect is obvious, and the heart rate can be increased by 10-40%.

The invention discloses MoSe2 nano-enzyme-selenium-rich probiotic composite hydrogel and a preparation method and application thereof, the composite hydrogel comprises a hydrogel matrix and functional components dispersed in the hydrogel matrix, and the functional components comprise anti-MoSe2 nano-enzyme and selenium-rich probiotics wrapped by an antioxidant film. According to the MoSe2 nano-enzyme-selenium-enriched probiotic composite hydrogel provided by the invention, the sonodynamic characteristics of the MoSe2 nano-enzyme and the biological activity of the selenium-enriched probiotics are perfectly fused: under ultrasonic stimulation, the MoSe2 nano-enzyme not only can directly and efficiently generate reactive oxygen species (ROS), but also can catalyze low-concentration hydrogen peroxide to generate a large amount of hydroxyl radicals (. OH); broad-spectrum killing of various pathogenic bacteria is achieved, and the risk of drug resistance evolution of bacteria is reduced from the source; meanwhile, antibiotics secreted by the selenium-enriched probiotics can form a synergistic sterilization effect, so that the pathogenic bacterium removal effect is further enhanced.

The invention relates to the technical field of biological materials, and discloses electrical stimulation LDH hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a zinc salt, a vanadium salt and urea in water in a nitrogen atmosphere to obtain a precursor solution; the precursor solution is subjected to a hydrothermal reaction, and ZnV-LDH is obtained; under stirring, gradually dropwise adding methacrylic anhydride into the gelatin solution, and heating for reaction; adding preheated water into the reaction liquid to stop the reaction; dialyzing and purifying the reaction liquid, pre-freezing, and freeze-drying to obtain hydrogel; and adding ZnV-LDH into the hydrogel, and carrying out ultrasonic mixing, so as to obtain the electrical stimulation LDH hydrogel. Through the synergistic effect of the ZnV-LDH and the hydrogel, the electrical stimulation LDH hydrogel disclosed by the invention has electrical activity and can generate potential change in response to external stimulation; under ultrasonic stimulation, concentration-dependent electrical response can be generated, the response has periodicity and stability, and osteogenic differentiation and cell mechanical properties can be promoted to the maximum extent.

The invention relates to a continuous crystallization system and method of lithium hexafluorophosphate, and belongs to the technical field of lithium ion battery electrolyte production. Aiming at the characteristics and requirements of a lithium hexafluorophosphate cooling crystallization process, the invention provides a continuous crystallization system of lithium hexafluorophosphate, which separates cooling nucleation from cooling crystallization. An ultrasonic generating device is introduced into the cooling nucleation module, lithium hexafluorophosphate is stimulated and induced by ultrasonic waves to nucleate, limitation of a metastable region is reduced, the nucleation rate is increased, crystal nuclei are controlled to be within a small particle size distribution range, meanwhile, introduction of impurities in the nucleation process is reduced, and the product purity is guaranteed. And the lithium hexafluorophosphate solution to be crystallized can continuously and uninterruptedly enter the cooling nucleation module, the cooling crystallization module and the separation circulation module in sequence, so that the continuous crystallization of the lithium hexafluorophosphate is realized, the crystallization time is greatly shortened, and the crystallization efficiency is improved.

This application relates to the technical field of data analysis and processing, and discloses a method and device for regulating sleep-wake circadian rhythm disorders based on ultrasonic stimulation. The method includes: collecting users' sleep physiological data to construct a feature matrix; analyzing the sleep stage to obtain the disorder type; generating an ultrasonic stimulation parameter scheme; determining the brain region stimulation coordinates to generate spatial positioning data; predicting the user's feedback through a convolutional neural network; comparing the prediction with the actual feedback to adjust the scheme, and obtaining an optimized target stimulation scheme. This application realizes the accurate identification of sleep-wake circadian rhythm disorders, the generation of personalized stimulation parameters, the precise brain region positioning, the predictive evaluation, and the dynamic scheme optimization, thereby improving the regulation effect of ultrasonic stimulation on various sleep-wake circadian rhythm disorders.

A biomimetic intervertebral fusion device with a piezoelectric multifunctional coating belongs to the field of implantable medical devices. It includes an upper piezoelectric multifunctional coating, a fusion device body, and a lower piezoelectric multifunctional coating. A bone graft window is located in the middle of the biomimetic intervertebral fusion device. The piezoelectric multifunctional coating is made of electrospun piezoelectric PVDF / HA fibers, which are conformally adhered to the upper and lower surfaces of the fusion device body through a polydopamine adhesive layer. The upper and lower surfaces of the fusion device body have a biomimetic curved surface configuration to match the morphology of the vertebral endplates, increasing the contact area and reducing stress concentration at the fusion interface. While maintaining an elastic modulus similar to natural bone and good radiation permeability, this fusion device, after implantation, can create a microenvironment conducive to cell adhesion and proliferation. Under the influence of cell traction, ultrasonic stimulation, and the physiological load of the human lumbar spine, it generates electrical stimulation signals, promoting bone fusion, improving the stability of the fusion interface, and reducing the risk of postoperative loosening and subsidence of the fusion device.

The utility model relates to the technical field of oral treatment, and discloses ultrasonic tooth orthodontic auxiliary treatment equipment and an oral treatment device, a denture base body is provided with a treatment part which can be selectively attached to gingiva, tooth covering grooves with different sizes can be formed by fitting gum shapes of different patients, the treatment part can be recycled, and the treatment effect is good. The universality of the ultrasonic tooth orthodontic auxiliary treatment equipment is improved, the treatment cost is reduced, the fit degree of the treatment part and the periodontium is higher, and the orthodontic auxiliary treatment effect is stabilized; the flexible circuit board is arranged in the treatment part and deforms together with the treatment part, conductor wiring used for transmitting electric energy is arranged in the flexible circuit board to integrate circuits, additional wiring is not needed, and wiring harness arrangement is neat; the ultrasonic transduction sheets which are in one-to-one correspondence with the teeth to be orthodontic and are arranged opposite to the gingiva are arranged in the treatment part and are electrically connected with the conductor wiring at the same time, assembly is simple, the ultrasonic transduction sheets are conveniently arranged in the oral cavity of a patient, ultrasonic stimulation is carried out on targeted parts of the teeth, and the orthodontic effect is improved.

A method for stimulating hydrogen production from an injection formation. This method includes the steps of providing a well traversing a subsurface into an injection formation containing hydrocarbons. Carbon dioxide, water, steam, and combustion gas are introduced into the injection formation via the well. Further, the injection formation is stimulated using one or more of infrasonic, sonic, and ultrasonic stimulation. The injection formation is monitored via one or more sensors located in the injection formation to determine one or more properties of reactions in the injection formation and the flow back effluent. Flowback operations are conducted to retrieve flowback effluent.

The invention belongs to the technical field of medicines, and relates to injectable piezoelectric hydrogel for a spinal cord injury part as well as a preparation method and application of the injectable piezoelectric hydrogel. According to the hydrogel, methacrylated gelatin is used as a carrier, and a piezoelectric material MOF (at) PDA (at) M0, namely MP (at) M, of an enveloping porous structure is loaded in the hydrogel. The hydrogel can achieve dual functions under the ultrasonic action: (1) MP (at) M has piezoelectricity, ultrasonic mechanical energy is converted into electrical stimulation, calcium ion inward flow of astrocytes is triggered, mitochondria is promoted to be transferred from the astrocytes to neurons, and the mitochondrial function of the neurons is recovered; (2) the CD73 enzyme carried by the microglial cell membrane coated on the surface of the MP (at) M can degrade pro-inflammatory ATP (adenosine triphosphate) at the damaged part to generate adenosine, so that astrocytes are promoted to release lactic acid, and rapid energy support is provided for neurons. Mitochondrial transfer and energy supply are synchronously promoted through ultrasonic stimulation, neuronal plasticity is remodeled, spinal cord axon regeneration is promoted, and a new strategy is provided for spinal cord injury treatment.

The invention relates to the technical field of medical data processing and three-dimensional modeling, and discloses a skull thickness distribution diagram construction method and system fusing ultrasonic thickness measurement and optical localization. According to the method, an ultrasonic probe is used for obtaining a skull thickness value at a measuring point of the scalp of a subject, and meanwhile, a three-dimensional space coordinate of the measuring point is accurately determined through an optical navigation positioning system. The system binds the thickness value and the space coordinates in real time to form thickness-space data points, and performs multi-point repeated acquisition on the scalp surface, thereby constructing a three-dimensional thickness point cloud. And finally, the upper computer system performs interpolation processing on the point cloud data to generate a skull thickness distribution diagram with spatial continuity. According to the method, the defect that the skull thickness data and the anatomical space positioning information are mutually independent is overcome, accurate space-time correspondence of the measured value and the space position is realized, an individualized skull model can be constructed quickly at low cost, and an accurate sound field compensation calculation basis is provided for applications such as transcranial ultrasonic stimulation.

The present application relates to the technical field of biological cell culture, and particularly relates to a fixed bed device and method for improving secretion and expression of exosomes. The device comprises a fixed bed reactor, an ultrasonic generator, a connecting flange and a control unit. The ultrasonic generator is installed on the top of the fixed bed reactor through the connecting flange. The control unit is configured to control the ultrasonic generator to apply ultrasonic stimulation to the cells intermittently in the whole cycle of cell culture. The ultrasonic intensity is dynamically regulated in three stages according to the culture cycle. The present application uses pure physical stimulation without adding chemical reagents. Under the premise of maintaining normal growth and activity of cells, the yield of exosomes can be increased by more than 169%. The present application is suitable for animal cells and plant cells and has a wide industrial application prospect. The technical problems of low yield of exosomes, stimulation mode that may affect cell activity or introduction of chemical reagents that may interfere in the prior art can be effectively solved.

The present invention discloses an intraocular irrigation solution containing niacinamide. Niacinamide serves as an active substance in the intraocular irrigation solution, which has the effects of improving the function of corneal endothelial cells, inhibiting cell apoptosis and cell fusion, and improving the mitochondrial damage condition, thereby alleviating or inhibiting corneal edema, reduction of corneal endothelial cells, abnormal corneal transparency, abnormal corneal thickness, abnormal corneal endothelial cell density, abnormal corneal endothelial cell morphology, and abnormal expression of corneal endothelial cell functional proteins caused by ultrasonic stimulation, heat stimulation or oxidative damage to corneal endothelial cells during phacoemulsification surgery.

The invention discloses a transcranial focused ultrasound stimulation thermal effect and mechanical effect simulation system and method, and relates to the technical field of biomedical engineering, and the system comprises a sound field effect simulation module which is used for calculating a brain sound field based on set ultrasonic parameters and a stimulation target in combination with a constructed human brain model; the biothermodynamic simulation is used for calculating the heat effect of different ultrasonic waves on the biological tissue on the main propagation path and the temperature change caused by the heat effect; the mechanical effect simulation is used for calculating the mechanical effect of the ultrasonic wave in the focusing area when the ultrasonic wave acts on the brain tissue, and calculating a mechanical index MI to evaluate the cavitation effect risk; evaluating the thermal injury of the soft tissue in the ultrasonic stimulation according to the cumulative energy model; according to the simulation system and method, sound field distribution and partial biological effects of transcranial focused ultrasound stimulation can be accurately analyzed.