200 results about "Ultrasonic stimulation" patented technology

The invention discloses a comprehensive regulation and control method and system based on multi-mode electromagnetic and ultrasonic stimulation, and the method comprises the steps: collecting brain wave signals in real time through a multi-electrode EEG system, synchronously collecting skin electroreaction and heart rate variability signals, preprocessing the collected signals, and carrying out the feature extraction; the extracted signal features are subjected to multi-modal feature fusion through a CNN, and the multi-modal features are subjected to time sequence dependency analysis through a long-short-term memory network to generate a real-time emotional state quantization vector and identify a current emotional state category. Through synchronous acquisition and feature fusion of multi-electrode EEG, EDA and HRV signals, a real-time brain function connection network is constructed, accurate recognition and stimulation strategy making are performed on emotion regulation and control nodes based on graph theory analysis, the accuracy and reliability of emotion recognition are improved, personalized regulation and control of individual emotion states are realized, and the emotion regulation and control efficiency is improved. The cognitive function and language expression ability of an individual can be improved, and movement coordination disorder caused by emotional fluctuation is reduced.

The high-cleanliness cleaning device comprises a cleaning basin, a plurality of ultrasonic transducers are annularly arranged on the side wall of the cleaning basin, the bottom face of the cleaning basin is connected with the bottom face of a vibration excitation plate through a spring seat, the vibration excitation plate is provided with a vibration exciter, and the center of the vibration excitation plate is rotationally connected with a leakage disc. The bottom surface of the drain plate is connected with the output end of a rotating motor through a universal joint A, the rotating motor is mounted below the cleaning basin, and a spraying mechanism is arranged above the cleaning basin; the technology comprises the five steps of pre-spraying cleaning, ultrasonic cleaning, neutral liquid cleaning, purified water cleaning and workpiece multi-stage drying. The cleaning equipment has the full-automatic rotary spraying function, ultrasonic excitation cleaning can be conducted on workpieces on the drain disc, the problems that the number of particles of the aluminum die-casting workpieces is out of tolerance, and the aluminum die-casting workpieces become yellow after being cleaned can be solved by combining two specially-made cleaning agents, the corrosion speed of elements such as silicon, copper and iron is increased while aluminum corrosion is slowed down, and the cleaning efficiency is improved.

The invention belongs to the technical field of transcranial ultrasonic stimulation. A transcranial focused ultrasound stimulation system and method for cognitive impairment patients is provided. The system comprises a main control module, a communication module, a display module, a signal source module, a driving module, an impedance matching module, an ultrasonic transducer module and an ultrasonic coupling module. According to the method, the personalized target spot can be determined according to the actual illness state of the target patient, and the appropriate treatment intensity can be determined, so that the optimal treatment effect can be obtained.

The invention relates to the technical field of data analysis and processing, and discloses a sleep-awakening circadian rhythm disorder adjusting method and device based on ultrasonic stimulation. The method comprises the following steps: collecting sleep physiological data of a user to construct a feature matrix; analyzing a sleep stage to obtain a disorder type; generating an ultrasonic stimulation parameter scheme; determining brain region stimulation coordinates to generate spatial positioning data; predicting user feedback through the convolutional neural network; and comparing the prediction and actual feedback adjustment schemes to obtain an optimized target stimulation scheme. According to the method and the device, accurate recognition, personalized stimulation parameter generation, accurate brain region positioning, predictive evaluation and dynamic scheme optimization of sleep-awakening circadian rhythm disorders are realized, so that the regulation effect of ultrasonic stimulation on various sleep-awakening circadian rhythm disorders is improved.

A method for stimulating hydrogen production from an injection formation. This method includes the steps of providing a well traversing a subsurface into an injection formation containing hydrocarbons. Carbon dioxide, water, steam, and combustion gas are introduced into the injection formation via the well. Further, the injection formation is stimulated using one or more of infrasonic, sonic, and ultrasonic stimulation. The injection formation is monitored via one or more sensors located in the injection formation to determine one or more properties of reactions in the injection formation and the flow back effluent. Flowback operations are conducted to retrieve flowback effluent.

The present invention relates to the technical field of ultrasonic diagnosis and treatment. The present invention provides an ultrasonic diagnosis and treatment device and a control method. The ultrasonic diagnosis and treatment device comprises: an ultrasonic transducer device, the ultrasonic transducer device comprises an ultrasonic imaging transducer and an ultrasonic stimulation transducer, the ultrasonic imaging transducer is used to perform ultrasonic imaging of a target area, and the ultrasonic stimulation transducer is used to perform ultrasonic stimulation on peripheral nerves or human epidermis; an ultrasonic electronic system connected to the ultrasonic transducer device, used to control the ultrasonic transducer device and realize ultrasonic imaging or ultrasonic stimulation regulation, the ultrasonic electronic system comprises an ultrasonic imaging circuit module and an ultrasonic stimulation circuit module, wherein the ultrasonic stimulation circuit module comprises a pulse generating circuit, a power amplifying circuit and a matching circuit, and the ultrasonic imaging circuit module comprises an imaging phased array transmitting unit, a receiving unit, an image processing unit and a system control unit; a mechanical arm is connected to the ultrasonic transducer device. Therefore, the present invention can realize the integrated design of peripheral ultrasonic diagnosis and treatment.

The invention discloses a multi-channel phase resonance transcranial ultrasonic regulation and control system and method based on 3D printing, and relates to the technical field of transcranial ultrasonic nerve regulation and control. Firstly, after three-dimensional modeling is conducted on the basis of patient head diagnosis and treatment data obtained in advance, a brain region needing to be stimulated is calibrated; then, on the basis of the acoustic theory, calculating a spatial position and an angle corresponding to the ultrasonic stimulation probe by applying an inversion technology; according to the calculation result, a personalized 3D printing helmet is designed, and a structure used for fixing an ultrasonic probe is printed on the top of the helmet; the device for fixing the ultrasonic stimulation probe adopts a special design, and the distance between the probe and the surface of a skull can be adjusted; the ultrasonic stimulation probe is composed of multiple channels and multiple array elements and can achieve phase resonance and adjust the focus position. Due to the fact that millimeter-level deviation exists in the system, a large amount of data are collected, an artificial intelligence model is established, modeling is conducted on 3D printing helmet system errors, after accurate errors are obtained, the focus position is further adjusted through the ultrasonic phase resonance technology, and accurate positioning is achieved.

The invention provides an ultrasonic stimulation system and method for improving sciatica under ultrasonic guidance, and belongs to the technical field of optics. According to the invention, original light field data is synthesized into event data for training a network, the event data is input into an event image reconstruction network module capable of converting continuous event streams into a series of intensity images to obtain light field event images, and then three-dimensional reconstruction of a target area is obtained through a three-dimensional image reconstruction network module. And a new technical reference is provided for solving the problem of how to improve the three-dimensional reconstruction quality and resolution of the light field microscope.

The invention discloses a closed-loop hemodynamic regulation imaging system and method for ultrasonic stimulation of peroneal nerves, and belongs to the technical field of ultrasonic stimulation regulation, and the system comprises a pulse Doppler ultrasonic imaging module, an ultrasonic stimulation parameter configuration module, a power supply module, an ultrasonic stimulation module, a feedback control module and an upper computer display module, the pulse Doppler ultrasonic imaging module is configured to perform color pulse Doppler imaging on the popliteal artery and the popliteal vein to obtain hemodynamic information of the two; the ultrasonic stimulation parameter configuration module is configured to receive the real-time ultrasonic stimulation parameters transmitted by the feedback control module and transmit the real-time ultrasonic stimulation parameters to the ultrasonic stimulation module through electric signals while configuring the real-time ultrasonic stimulation parameters according to the real-time ultrasonic stimulation parameters. According to the invention, hemodynamic real-time observation of ultrasonic stimulation of the peroneal nerve, the popliteal artery and the popliteal vein can be simultaneously carried out, automatic adjustment of hemodynamics can be realized by using a fuzzy logic control algorithm, blood circulation of legs is improved, and real-time and convenient adjustment effect detection is provided for ultrasonic stimulation of the peroneal nerve.

The invention relates to the technical field of nerve probes, and provides a four-mode integrated nerve probe and a preparation method thereof. The four-mode integrated nerve probe provided by the invention comprises a flexible substrate, an electric signal recording module, an ultrasonic stimulation module, a light stimulation module and a microfluidic channel. The electric signal recording module is used for recording electroneurographic signals, the ultrasonic stimulation module is used for ultrasonic stimulation, the optical stimulation module is used for optical stimulation and signal recording, and the microfluidic channel is filled with drugs through a microfluidic channel control port in the probe body and releases the drugs through a microfluidic channel outlet in the needle tip. According to the four-mode integrated nerve probe provided by the invention, multiple functions are integrated into one probe, so that comprehensive detection and regulation of a nervous system are realized, and the technical problems that a traditional nerve probe is single in function, inflammation is caused by a rigid material and multi-mode integration is insufficient are solved.

The invention provides a scalp brain signal acquisition method and system, a medium and electronic equipment, and relates to the technical field of brain-computer interfaces. The scalp brain signal acquisition method comprises the following steps: determining excitation signal parameters of FUS according to head acoustic parameters; the excitation signal parameters are used for enabling the irradiation focus of focused ultrasound FUS of the ultrasonic phase control transducer to be located on the scalp contour; in response to the ultrasonic stimulation instruction, controlling the ultrasonic phased transducer to generate an array element excitation signal based on the excitation signal parameter so as to perform ultrasonic irradiation on the irradiation focus; and in response to the electroencephalogram acquisition instruction, acquiring an electroencephalogram signal to obtain a focused ultrasound modulated scalp electroencephalogram signal. According to the method, the accuracy of the scalp electroencephalogram signals can be improved.

Disclosed are devices, systems, and methods for ultrasonically stimulating brain tissue using operating parameters associated with a. target region of a brain. The operating parameters can be determined, for example, by combined ultrasonic stimulation and photometry devices and methods. The operating parameters can include pulse repetition frequency, temporal compression, and intensity. Using selected operating parameters, ultrasound stimulation of the target region of the brain can excite or inhibit brain cell activity.

The invention provides an ultrasonic activated azido precursor, a prodrug and application. The precursor and an active drug react and are bonded to obtain the azido prodrug; the bonding group of the active medicine is amino, hydroxyl or sulfydryl; a bonding group of the ultrasonic activated azido precursor is an ester group. Novel ultrasonic activatable groups, namely p-azidobenzyloxycarbonyl and derivatives thereof, are adopted, hydrogen atoms on a benzene ring are substituted to different degrees, the reducing capacity of a precursor can be remarkably improved, azide is effectively reduced into amino through ultrasonic stimulation under the action of TBR and NADH, and then a self-elimination reaction is induced to release active drugs. The structure has the advantages that different types of active drugs (active pharmacodynamic groups can be amino, hydroxyl and sulfydryl) can be bonded through 4-nitrophenyl carbonate, high-selectivity reduction is performed under the triple action of ultrasound, TBR and NADH, active raw drugs are released according to needs, and toxicity reduction and synergism are achieved.

The utility model discloses an ultrasonic wearing device for tooth orthodontics, which comprises a U-shaped seat and a plurality of supports arranged on the U-shaped seat, each support is of a U-shaped structure, a corresponding ultrasonic transducer is arranged on each support, the plurality of ultrasonic transducers correspond to the corrected teeth of a patient in number and position, and the plurality of ultrasonic transducers are arranged on the U-shaped seat. The ultrasonic transducer is used for performing ultrasonic stimulation on the tooth root. According to the utility model, the arrangement direction of the conductor on the bracket is matched with the opening direction of the sliding groove, the bracket is inserted into the sliding groove through the conductor, and then the bracket is rotated by 90 degrees, so that the two ends of the conductor are inserted into the conduction end, a damping effect on the conductor is achieved, and the bracket is more convenient to disassemble and assemble; the support can be mounted or dismounted only by rotating the support by 90 degrees to enable the extending direction of the conductor to correspond to the forming direction of the sliding groove, and due to the fact that the ultrasonic transducer is arranged on the support, replacement of the ultrasonic transducer in the later period is more convenient.

The invention discloses stimuli-responsive cross-linked polyamide and a preparation method and a stimuli-responsive method thereof, and relates to the technical field of polymer synthesis, and the preparation method of the cross-linked polyamide comprises the following steps: heating linear furyl polyamide and a cross-linking agent in a solvent B for reaction to prepare the cross-linked polyamide. The stimuli-responsive crosslinked polyamide is excellent in comprehensive performance, the stimuli-responsive mode is simple, the preparation method is green and convenient, the polyamide is synthesized through a one-pot method, the crosslinked polyamide is synthesized through a DA reaction, and the thermal property and the mechanical property are excellent; in addition, reversible crosslinking occurs under ultrasonic stimulation response, and the thermal performance and the mechanical performance of polyamide can be controllably adjusted. The polyamide performance controllable adjustment method provided by the invention expands the application of polyamide in the fields of biomedical treatment and the like.

The invention relates to a method for promoting nerve cell proliferation and differentiation based on ultrasonic stimulation and application, and belongs to the technical field of biomedicine. According to the method, under the conditions that the power is 90-110 mW and the frequency is 0.9-1.1 MHz, nerve cells are continuously stimulated for 3 days by ultrasonic waves once per day, and each time lasts for 2-4 min. The purposes of increasing the nerve cell proliferation speed and promoting nerve cell differentiation are achieved only through ultrasonic stimulation under specific conditions for the first time, no other substances are added, non-invasion and non-contact are achieved, and toxic and side effects on cells are low; the nerve cells are not subjected to invasive or modified operation; the method has a wide application prospect only through physical conditions.

The invention relates to the technical field of ultrasonic treatment, and discloses an ultrasonic phased array acupuncture system for simulating acupuncture manipulation, comprising: a signal control module comprising M signal channels, the signal control module generating different ultrasonic pulse signals in different signal channels in response to selection of acupuncture manipulation modes and sound field parameters; the ultrasonic phased array module comprises M planar array elements located on the same plane, the ultrasonic phased array module is used for receiving the ultrasonic pulse signals of the signal control module, and the ultrasonic pulse signals of the M signal channels control the M planar array elements respectively; the planar array elements comprise N focusing array elements and P angular momentum array elements; angular momentum array elements are distributed in a circular ring array; m = N + P; and the N focusing array elements and / or the P angular momentum array elements emit different ultrasonic pulses under the control of different ultrasonic pulse signals. Two sound fields are adopted, the acupuncture points of the human body are subjected to ultrasonic stimulation accurately and effectively, and the treatment effect of acupuncture and moxibustion is improved.

The present invention comprises: an ultrasonic wave generation device for generating a pulse bundle, which has a low intensity of intensity spatial peak pulse average (ISPPA) 50 W / cm2 or less and which is composed of pulses of a first frequency through ultrasonic waves, and forming, through the pulse bundle, a second frequency and outputting same; a transducer which is connected to the ultrasonic wave generation device, and which irradiates the brain of a mammal with ultrasonic waves so as to stimulate the frontal lobe area of the brain with the ultrasonic waves; and a head frame on which the transducer is mounted and which can be worn on the head of the mammal, wherein the transducer is mounted on the head frame such that the position and angle formed with the head through a rail structure and a hinge structure provided on the head frame can be adjusted, so as to selectively adjust the frontal lobe stimulation position of the brain stimulated by irradiation of the ultrasonic waves while moving along the head, and thus customized ultrasonic wave irradiation is performed in correspondence to a body region of a user requiring ultrasonic wave irradiation.

A method for stimulating hydrogen production (200) from an injection formation (102). This method includes the steps of providing a well system (106) traversing subsurface formations (104) into an injection formation (102) containing hydrocarbons. Carbon dioxide, water, steam, and combustion gas are introduced into the injection formation (102) via the well system (106). Further, the injection formation (102) is stimulated using one or more of infrasonic, sonic, and ultrasonic stimulation (225). The injection formation (102) is monitored (230) via one or more sensors located in the injection formation (102) to determine one or more properties of reactions in the injection formation (102) and the flow back effluent. Flowback operations (240) are conducted to retrieve flowback effluent.

The invention discloses individualized variable parameter closed-loop ultrasonic stimulation equipment and method based on deep learning, and belongs to the technical field of transcranial ultrasonic stimulation. The individualized variable parameter closed-loop ultrasonic stimulation equipment comprises an electroencephalogram signal acquisition module, an electroencephalogram signal processing module, an electroencephalogram signal deep learning judgment module and an ultrasonic stimulation module; the electroencephalogram signal acquisition module acquires electroencephalogram signals of an experimental subject within a specified finite time and transmits the electroencephalogram signals to the electroencephalogram signal processing module; the electroencephalogram signal processing module preprocesses and displays the electroencephalogram signals in real time, splits the electroencephalogram signals according to specified time, and stores all electroencephalogram signal segments in a picture format; the electroencephalogram signal deep learning discrimination module discriminates an electroencephalogram abnormal level and appoints effective ultrasonic stimulation parameters; and the ultrasonic stimulation module performs variable parameter ultrasonic stimulation on the experimental subject. According to the method, deep learning training is carried out on large sample electroencephalogram signals, an electroencephalogram signal deep learning model is established, the electroencephalogram abnormal level of any other experimental subject is judged, and variable parameter closed-loop ultrasonic stimulation is carried out.

The invention relates to a closed-loop transcranial acoustic-magnetic stimulation neural circuit regulation and control system and method, and the system comprises an individualized simulation navigation module which is used for carrying out the simulation navigation of ultrasonic stimulation and magnetic stimulation on a brain region of a regulation and control object, and obtaining a stimulation site; the transcranial ultrasonic stimulation module is used for outputting ultrasonic stimulation by adopting the initialized stimulation parameters according to the stimulation sites and carrying out transcranial ultrasonic stimulation on the regulation and control object; the transcranial magnetic stimulation module is used for outputting magnetic stimulation by adopting the initialized stimulation parameters according to the stimulation sites and carrying out transcranial magnetic stimulation on the regulation and control object; and the electroencephalogram collecting, processing and feedback module is used for synchronously collecting and analyzing electroencephalogram signals in the acoustic and magnetic combined stimulation process and optimizing stimulation parameters. According to the method, high spatial resolution of transcranial ultrasonic stimulation, flexibility of transcranial magnetic stimulation and real-time processing of electroencephalogram data are combined, and accurate individualized neural circuit regulation and control are achieved.

The invention discloses an ear acupoint closed-loop ultrasonic stimulation system and method based on sleep electroencephalogram signal feedback, and belongs to the technical field of ultrasonic stimulation nerve regulation and control. The ear acupoint closed-loop ultrasonic stimulation system comprises an electroencephalogram acquisition module, a regulation and control module, an ultrasonic transmitting module and a dynamic association module; the electroencephalogram acquisition module is used for acquiring electroencephalogram signals within limited time specified by a user according to specified sampling frequency, amplifying and filtering the acquired signals and sending the processed signals to the regulation and control module; the regulation and control module judges the current sleep stage of the user, drives the ultrasonic transmitting module, performs variable parameter closed-loop ultrasonic stimulation on the user, and automatically adjusts stimulation parameters and duration according to the current sleep stage; and the dynamic association module sets a multi-threshold triggering mechanism based on the real-time electroencephalogram characteristic parameters and discriminates a specific physiological status. According to the invention, accurate acupoint stimulation can be realized, a real-time feedback mechanism is provided, and the accuracy and effectiveness of stimulation can be ensured.

The invention discloses a transcranial ultrasonic stimulation device and a focal length adjusting method, and relates to the technical field of medical instruments and ultrasonic therapy. The screwing assembly is arranged on the outer side of the bottom of the ultrasonic transducer, and the ultrasonic transducer is rapidly disassembled and assembled through the screwing assembly; and the ultrasonic coupling assembly is arranged at the bottom of the screwing assembly and is matched with the ultrasonic transducer, and the ultrasonic coupling assembly is used for reducing air gaps during fitting so as to reduce the sound energy loss. Through the cooperative arrangement of the ultrasonic transducer, the screwing assembly and the ultrasonic coupling assembly, accurate ultrasonic conduction can be achieved, the device can adapt to a complex head shape, especially in complex target spots such as binaural areas, the flexible characteristic of the soft bag ensures that the soft bag is tightly attached to the head tissue, and the effect that the soft bag is tightly attached to the head tissue is achieved. Consistent sound wave conduction can be provided, interference of air or other substances is avoided, and the treatment effect is remarkably improved.

The invention discloses an ultrasound-electroencephalogram multifunctional electrode for deep brain stimulation. The multifunctional electrode sequentially comprises a matrix microtube, a PMUT electrode for deep brain ultrasonic stimulation and an SEEG electrode for electroencephalogram signal detection from inside to outside. The ultrasonic-electroencephalogram multifunctional electrode for deep brain stimulation has the functions of fixed-point ultrasonic nerve stimulation and in-situ electroencephalogram signal detection, provides powerful support for closed-loop nerve stimulation in the future, and meanwhile has the advantages of being simple in preparation process, low in manufacturing cost and the like.

The invention relates to the technical field of laser ultrasound, and particularly discloses a multi-dominant-frequency laser ultrasonic holographic system and a design method.The system comprises a laser and a laser beam adjusting module used for receiving and adjusting laser beams, the laser beam adjusting module comprises a beam expanding lens and a collimating lens which are coaxially arranged, the beam expanding lens is used for adjusting the diameter of the laser beams, and the collimating lens is used for adjusting the diameter of the laser beams; the collimating mirror is used for collimating the laser beams so that the laser beams are kept parallel and focused; the frequency mixing ultrasonic holographic lens comprises a light focusing layer, a sound restraint layer, a light absorption layer, a sound matching layer and a sound holographic layer which are stacked in sequence, and the frequency mixing ultrasonic holographic lens is used for receiving the laser beams passing through the laser beam adjusting module so as to generate multiple stable single or multiple focusing ultrasonic sound fields with different preset frequencies in a time-sharing or simultaneous manner; and the focusing focus position and power can be adjusted, so that the device can be used for ultrasonic control and driving, ultrasonic detection imaging, low-power ultrasonic stimulation or power ultrasonic treatment and the like.

The invention relates to the field of biological medicine, and discloses multifunctional nano hydrogel as well as a preparation method and application thereof. The multifunctional nano hydrogel is prepared from the following raw materials: glutathione modified silk protein, metacrylic acid esterified pectin and an MXene coated TiO2 nanosheet. According to the multifunctional MXene-coated TiO2 biological heterojunction hydrogel provided by the invention, space-time controllable antibacterial treatment and enhanced tissue regeneration are realized through dynamic ROS (reactive oxygen species) adjustment triggered by ultrasonic waves. The hydrogel can rapidly kill bacteria under ultrasonic stimulation, meanwhile, excessive ROS is removed after ultrasound is stopped, and the double challenges of oxidative stress and tissue regeneration are effectively solved.

The invention discloses a closed-loop ultrasonic regulation and control system for a targeted deep brain area. A bio-electricity signal collector collects bio-electricity signals of a detection target and uploads the bio-electricity signals to a main control unit. The main control unit identifies the bio-electricity signal and outputs an excitation signal to the signal generator after identifying a characteristic electric signal. The signal generator generates an ultrasonic waveform signal according to the ultrasonic parameter. Signals are amplified by a power amplifier and then input to an ultrasonic transducer, corresponding mechanical waveforms are output under voltage excitation, then bioelectricity signals are collected in real time for neural activity reaction after ultrasonic stimulation, and closed-loop ultrasonic regulation and control are achieved. According to the invention, electric signals are recorded at the same time, ultrasonic stimulation parameters are fed back in real time, a remarkable inhibition effect is generated on mouse epilepsy electroencephalogram, ultrasonic output energy is automatically adjusted, and the possibility of adverse reaction is reduced. The ultrasonic transducer is firmly fixed on the head of the mouse by the adaptive device, so that ultrasonic regulation and control on the freely moving mouse are realized, and the mouse is not limited by anesthesia stimulation.

The invention discloses a self-adaptive closed-loop ultrasonic stimulation system and method based on Actor-Critic reinforcement learning, and belongs to the field of neural regulation and control technologies and biomedical engineering, and the system comprises a signal collection module, a preprocessing module, an Actor strategy module, a Critic value module, an ultrasonic stimulation module, a safety monitoring module and a storage module. The Actor strategy module generates safe and controllable ultrasonic stimulation parameters according to the preprocessed electroencephalogram data; the safety monitoring module is used for checking whether the ultrasonic stimulation parameters generated by the Actor module meet safety standards or not; the ultrasonic stimulation module sends out an ultrasonic stimulation signal according to the ultrasonic stimulation parameter; and the Critic value module evaluates the electroencephalogram feedback effect after ultrasonic stimulation and provides feedback to the Actor module for optimizing the experimental strategy of the next step. The invention aims to intelligently adjust the ultrasonic stimulation parameters through the biofeedback data monitored in real time in combination with the reinforcement learning algorithm.

The invention discloses a multifunctional transcranial therapeutic apparatus and a control method thereof. The transcranial therapeutic apparatus relates to the field of medical equipment and solves the problem of single function of a traditional transcranial therapeutic apparatus. The transcranial electrical stimulation module can transmit direct current stimulation or alternating current stimulation; the transcranial magnetic stimulation module can provide a pulsed magnetic field; the ultrasonic stimulation module generates ultrasonic waves through an ultrasonic transducer. The multiple stimulation heads are used for being distributed in different areas of the head, an electrical stimulation electrode slice of the transcranial electrical stimulation module, a magnetic stimulation coil of the transcranial magnetic stimulation module and an ultrasonic transducer of the ultrasonic stimulation module are integrated in each stimulation head, and signal generators of all the modules are controlled in a unified mode through the main controller. A single stimulation mode or combined work of multiple stimulation modes is selected according to the illness state and treatment requirements of a patient, the different stimulation combination modes synergistically act on a target brain area, the treatment effect is improved, and the problems that a traditional transcranial therapeutic apparatus only supports a single stimulation mode and is poor in treatment effect are solved.

The preparation method comprises the following steps: by taking an oriented polylactic acid nanofiber membrane as a raw material, carrying out homogenization treatment to obtain polylactic acid piezoelectric short fibers; gelMA is used as a skeleton matrix, polylactic acid short fibers, LAP and DRG cells are compounded, a 0 / 90-degree alternate grid structure scaffold is constructed through pneumatic extrusion type biological printing, and the dual-network piezoelectric biological scaffold is formed through blue light crosslinking curing. The piezoelectric effect of polylactic acid short fibers is activated through ultrasonic stimulation, mechanical energy is converted into local electric signals, loaded DRG cells are directly driven to secrete CGRP in situ, macrophages are dynamically regulated and controlled to be polarized to M2 anti-inflammatory phenotypes, nerve-immune microenvironment disorder of diabetic bone defects is corrected, vascularization and bone regeneration are promoted, and the diabetic bone defect treatment effect is improved. The problems of short delivery half-life period of traditional cell factors, difficulty in nerve function reconstruction and chronic inflammation caused by non-degradable piezoelectric materials are solved, and non-invasive and degradable precise bone repair is realized.