The application discloses a portable
fluorescence lifetime detection device based on a SiPM array and an on-
chip TDC, and relates to the technical field of
fluorescence lifetime detection devices, and comprises the following modules: an excitation
light source module, which is used for sending a synchronous electric pulse
signal to a time measurement module while triggering a sub-
nanosecond excitation pulse, the
signal being a starting timing
signal for time measurement of the time measurement module, and the
excitation pulse being used for exciting a sample to be measured to generate a
fluorescence signal; a detection module, which is used for collecting the fluorescence signal and obtaining a
photon detection signal, and outputting each
photon detection signal to the time measurement module; the time measurement module, which is used for measuring a time interval from the synchronous electric pulse signal to each
photon detection signal to generate a
timestamp sequence and then sending the
timestamp sequence to a
data processing and control module; and the
data processing and control module, which is used for generating a fluorescence
decay curve and a fluorescence lifetime prediction result of the sample according to the
timestamp sequence. The application can meet the application requirements of portability, low cost, high stability and high accuracy.