A method of double-contrast magnetic
resonance fingerprinting including: optimizing, using Cramér-Rao lower bound (CRLB) via a computer
system, radiofrequency (RF) pulse parameters in an MRF sequence; loading, via the computer
system, the RF pulse parameters optimized into an MRI
scanner; and capturing raw k-space data by selecting different
signal contrast modules for dual-contrast encoding at varying repetition times (TR); reconstructing, via the computer
system, at least one image including a plurality of pixels; defining, via the computer system, a
dynamic range and step size for tissue parameters; and creating, via the computer system, a dictionary based on Bloch equations, the
dynamic range, and the step size; and comparing, via the computer system,
signal evolution for each of the plurality of pixels in the at least one image to the dictionary to determine quantitative parameters for each of the plurality of pixels, and generating a quantitative parameter map.