2230 results about "Inhalation" patented technology

A device and method for delivering a fluid as an ejected stream of droplets during inhalation uses inertial filtering to cause a first plurality of droplet particles generated by an ejector mechanism to pass through an airflow exit while a second plurality of droplet particles having a greater mass mean aerodynamic diameter than the first plurality of droplet particles fails to pass through the airflow exit.

The technology described herein is directed to spray-dried biotherapeutic matrix compositions comprising a bacterial preparation, which is formulated for administration by inhalation. Also described herein unit dosage forms of such spray-dried biotherapeutic matrix compositions, devices comprising such pharmaceutical compositions, methods of producing such pharmaceutical compositions, and methods of treating diseases, such as bronchopulmonary diseases, among others, using such spray-dried biotherapeutic matrix compositions.

The present invention provides an inhaler comprising a housing which contains a blister strip having a plurality of blisters which contain powdered medicament for inhalation, a mouthpiece mounted to the housing through which the medicament is inhaled by a user, an indexing and opening mechanism for indexing the blister strip and for opening the blisters which is operated by an actuator, wherein the blister strip is indexed by forward motion of the actuator from a first position to a second position, such as by opening a cover, and is also indexed in the same direction by reverse motion of the actuator from the second positon to the first position, such as by closing the cover.

The present invention provides an inhaler comprising a housing which contains a blister strip having a plurality of blisters which contain powdered medicament for inhalation; a mouthpiece through which the medicament is inhaled by a user; an indexing wheel for indexing the blister strip; an opening mechanism for opening the blisters; an actuator which is movable between a first position and a second position in order to operate the indexing wheel and the opening mechanism; and a coupling mechanism for coupling the actuator to the indexing wheel so that the indexing wheel rotates together with the actuator during part of the motion of the actuator; characterized in that the coupling mechanism comprises a shuttle that rotates on the same axis as, and translates axially relative to, the indexing wheel.

The present disclosure relates to an aerosol delivery system e.g. a smoking substitute system. In particular, it relates to an aerosol generating system comprising a vaporiser, an air flow sensor configured to detect a user inhalation through the system, and a controller, wherein the controller is configured to activate the vaporiser only when the duration of the user inhalation exceeds a predefined duration threshold.

A mist inhaler device (200) for generating a mist including a therapeutic for inhalation by a user. The device includes a mist generator device (201) and a driver device (202). The driver device (202) is configured to drive the mist generator device (201) at an optimum frequency to maximise the efficiency of mist generation by the mist generator device (201).

The invention provides acorus tatarinowii, cinnamon and cinnamon odor-absorbing traditional Chinese medicine compound essential oil for treating or improving depression, and relates to the technical field of traditional Chinese medicine essential oil, the traditional Chinese medicine compound essential oil is prepared from acorus tatarinowii essential oil, cinnamon essential oil, ginger essential oil, radix curcumae essential oil, pericarpium citri reticulatae essential oil and mint essential oil; the traditional Chinese medicine compound essential oil provided by the invention can obviously or obviously improve apparent symptoms of depression model mice; the sweet water preference rate is remarkably or obviously increased, the movement time of the mouse is prolonged, and the activity of the mouse is improved; according to the traditional Chinese medicine compound essential oil disclosed by the invention, the expression level of IL-1beta and TNF-alpha in serum indexes is reduced, the expression level of DA, 5-HT, NE, BDNF, cAMP and P-CREB in brain tissue homogenate is improved, the traditional Chinese medicine compound essential oil has a remarkable improvement effect on depression, and the traditional Chinese medicine compound essential oil is administered in a sniffing manner, so that the anti-depression effect of the traditional Chinese medicine compound essential oil is equivalent to that of oral fluoxetine hydrochloride and is superior to that of oral capsules for soothing liver and relieving depression. The calamus-osmanthus fragrans odor-absorbing traditional Chinese medicine compound essential oil provided by the invention provides a new treatment thought and method for treating or improving depression.

An electronic droplet delivery device having a mouthpiece of inhalation of droplets includes an aperture plate with a plurality of openings coupled to a piezoelectric actuator. A fluid reservoir supplies a solution with nicotine to the aperture plate for ejection out of the mouthpiece in a droplets stream.

A hookah device (202) which attaches to a hookah (246). The hookah device (202) comprises a plurality of ultrasonic mist generator devices (201) for generating a mist for inhalation by a user. The hookah device (202) comprises a driver device (202) which controls the mist generator devices (201) to maximize the efficiency of mist generation by the mist generator devices (201) and optimize mist output from the hookah device (202).

Disclosed herein is a medical system (100, 400) comprising: a magnetic resonance imaging system (102) configured for providing a respiratory signal. The respiratory signal is descriptive of a respiratory position as well as of inhalation and exhalation of the subject. The execution of machine executable instructions (140) causes the computational system to repeatedly: perform (200) the individual acquisition of k-space data using the magnetic resonance imaging system; receive (202) the respiratory signal; bin (204) the individually acquired k-space data into one of a predetermined number of k-space bins (148) using the respiratory signal and perform outlier rejection. Execution of the machine executable instructions further causes the computational system to reconstruct (208) a magnetic resonance image for each of the predetermined number of k-space bins to provide a respiratory-state resolved magnetic resonance image (150).

The invention relates to the field of anesthetic concentration regulation and control, in particular to a method for analyzing and evaluating the administration concentration of an inhalation type anesthetic. The method comprises the following steps: firstly, according to characteristic data such as basic physiological data, previous anesthesia sensitivity and operation information of a patient, applying a fuzzy matching algorithm to obtain an initial administration concentration; physiological sign data such as blood pressure, heart rate, pulse oxyhemoglobin saturation and end-expiratory carbon dioxide partial pressure of the patient are monitored in real time in the anesthesia process and compared with a normal range, whether the physiological sign data are abnormal or not is judged, and an adjustment scheme of the administration concentration is determined according to the administration concentration-physiological sign correlation model; after the administration concentration is adjusted, the electroencephalogram double-frequency index is monitored to evaluate the anesthesia depth, the anesthesia depth matching degree is analyzed to judge the adjustment effect, and therefore closed-loop control over the anesthetic administration concentration is achieved. According to the method, the administration concentration can be accurately regulated and controlled, the concentration regulation mechanism is optimized, the safety and effectiveness of the anesthesia process are effectively improved, and a reliable guarantee is provided for clinical anesthesia.

Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.

A respirator muscle training device comprises a main unit including at least one adjustable air metering vent, the main unit comprising a stem configured to accept a replaceable mouthpiece; and a replaceable mouthpiece configured to mate with the stem, the replaceable mouthpiece being configured to deliver air flow between the main unit air metering vent and a patient's mouth. The mouthpiece defines at least one supplementary metering channel that predictably modifies a resistance of the respirator muscle training device to user inhalation and / or exhalation through the device. An intermediate component containing sensors and other electronics monitors the flow of air through the training device and provides measured parameters to an external device that can use the measurements in a breathing game.

The invention relates to the technical field of emotional robots, and discloses an embracing emotional robot which comprises an inner shell, low-cost and high-simulation breathing simulation is achieved through cooperative control of an air pump and an air valve, and the embracing emotional robot is designed by combining simulation body temperature brought by a heating piece and synchronous action of a rotatable arm. The emotion robot can naturally rotate forwards when being embraced and is matched with simulated respiration and simulated body temperature, so that the immersion and emotion interaction experience of a user are remarkably improved; the operation cycle of the air pump strictly follows biological breathing characteristics, the inspiration stage accounts for 2 / 3 of the breathing cycle, the speed of the inspiration stage changes fast and slow, the expiration stage accounts for 1 / 3 of the expiration stage, smooth pressure relief is achieved through the air valve, and the highly-simulated breathing mode can effectively guide a user to breathe synchronously, so that parasympathetic nerves are activated, the anxiety level and heart rate fluctuation are reduced, and the user experience is improved. And the whole structure adopts a modular design, complex functions such as breathing simulation, embracing and body temperature simulation can be realized, the maintenance is convenient, and the device is particularly suitable for long-term accompanying scenes.

The utility model discloses a puncture rotary cutting needle for thyroid nodule treatment, which is characterized in that an outer tube and an inner tube are sleeved on the puncture rotary cutting needle, the inner tube is rotatably connected in the outer tube, and an outer side rotary cutting opening and an inner side rotary cutting opening are respectively arranged on the outer tube and the inner tube and are matched to form a rotary cutting window communicated with an inner cavity of the inner tube; the far end of the outer tube is constructed to be provided with the puncture tip, so that a puncture function is further realized on the basis of realizing rotary cutting and suction, thyroid tissues can be punctured and rotary-cut at the same time in a puncture entering process, the condition that the thyroid tissues need to enter and exit for multiple times is avoided, and the problem that an existing rotary cutting planer tool is difficult to adapt to a thyroid surgery scene is solved. According to the embodiment, the far end of the outer side rotary cutting opening extends to a part of the puncture tip, so that the opening position of the rotary cutting window at the far end is relatively lower than the opening position of the rotary cutting window at the near end, and when the thyroid tissue is sucked under negative pressure, the adsorption force to the thyroid tissue at the far end can be larger; and therefore, a better inhalation effect can be obtained.

The invention discloses multifunctional patient oxygen inhalation equipment, and relates to the technical field of medical equipment, the multifunctional patient oxygen inhalation equipment comprises an inhalation bottle body, one side of the inhalation bottle body is connected with an oxygen inhalation tube, a noise reduction mechanism is arranged in the inhalation bottle body, the inhalation bottle body comprises an upper cover body and a lower cover body, the upper cover body and the lower cover body are detachably connected, a first sealing plate is arranged in the upper cover body, and a second sealing plate is arranged in the lower cover body. A second sealing plate is arranged in the lower cover body, air outlets are formed in the two sides of the upper cover body, an air inlet head is integrally formed on the side wall of the upper cover body, a positioning mechanism is arranged between the upper cover body and the lower cover body, an adjusting mechanism is arranged in the first sealing plate, the positioning mechanism is matched with the adjusting mechanism, and rapid positioning of the upper cover body and the lower cover body can be achieved through the positioning mechanism. When positioning is achieved, gas channels between the upper cover body and the lower cover body are rapidly communicated through cooperation of the linkage piece and the annular piece, meanwhile, the situation that when the device is used, using of a patient is affected due to the fact that the sealing plug protrudes outwards is avoided, and the comfort of the patient is improved.

The invention belongs to the technical field of bionic nano-drugs, and particularly relates to a bionic vesicle preparation as well as a preparation method and application thereof. The bionic vesicle preparation disclosed by the invention is prepared from the following raw materials: mesenchymal stem cell outer vesicles, nintedanib and DSPE-PEG-HA (hyaluronic acid modified pegylated phospholipid); the nintedanib is loaded in the mesenchymal stem cell outer vesicle, and the DSPE-PEG-HA is coupled to the surface of the mesenchymal stem cell outer vesicle. The bionic vesicle preparation disclosed by the invention can be used for directly delivering a drug to a pulmonary fibrosis injury part through inhalation type drug delivery, and acting on a focus part at a higher local concentration, meanwhile, the exposure of the drug in whole-body circulation is remarkably reduced, the occurrence of side effects is reduced, and the specific targeting intervention and regulation on fibroblasts are realized.

The invention relates to the technical field of electronic atomizer control, in particular to an electronic atomizer intelligent control system based on airflow induction, which comprises a data acquisition synchronization module, an inspiration behavior analysis module, a power and smoke regulation module, an atomizer adaptation control module and an atomizer energy consumption management module. According to the invention, through synchronous acquisition of airflow and environmental data, the response capability of the device to the inhalation behavior of the user is improved, and through analysis of the inhalation mode prediction data of the user, the power output of the electronic atomizer is automatically adjusted, so that the smoke yield is consistent with the real-time demand of the user; meanwhile, the smoke density and quality are dynamically adjusted according to environmental factors, optimization of smoke output is ensured, the ideal state of smoke can be maintained no matter how environmental conditions change, energy consumption is effectively reduced through fine power control, the service life of a battery is prolonged, the overall energy efficiency of the electronic atomizer is improved, and meanwhile user experience is enhanced.

The invention provides an inhalable tanshinone IIA lipid nanocrystal as well as a preparation method and application thereof, and the inhalable tanshinone IIA lipid nanocrystal is mainly formed by entrapping tanshinone IIA by using dipalmitoyl phosphatidylcholine DPPC and dipalmitoyl phosphatidyl ethanolamine DPPE as mixed phospholipids in the presence of a stabilizer. Compared with the prior art, the inhalable tanshinone IIA lipid nanocrystal disclosed by the invention has the advantages that by improving the physicochemical property and drug release behavior of TA, the lung retention volume of TA after aerosol inhalation is obviously increased, the retention time of TA in the lung is prolonged, and the risk of toxic and side effects caused by whole-body escape of drugs is reduced; the treatment effect on idiopathic pulmonary fibrosis is improved, and the compliance of a patient is improved.

The invention discloses an intelligent atomization control method and system for respiratory tract treatment and a storage medium, and relates to the technical field of atomization control. During operation of the system, a multi-mode patient respiratory behavior monitoring module is used for capturing real-time respiratory frequency, depth, rhythm, cough characteristics and atomization efficacy based on a non-contact sonic sensor and lung sound analysis; the method comprises the following steps: monitoring environment humidity, temperature and aerosol diffusion rate in real time, analyzing the influence of the environment humidity, temperature and aerosol diffusion rate on drug mist particle size and sedimentation behavior, controlling atomization particle size through a variable-frequency ultrasonic exciter, calculating to obtain an intelligent atomization curative effect adaptation index AEAI, dynamically adjusting particle size distribution according to the real-time inhalation demand of a patient and environment parameters, and combining with respiration monitoring data to obtain the intelligent atomization curative effect adaptation index AEAI. According to the method, the medicine mist release opportunity is adjusted in real time, threshold value comparison is carried out by monitoring respiratory resistance changes and real-time feedback of lung sound characteristic improvement degree, a medicine release strategy is obtained, and remote doctor viewing and parameter adjusting functions are provided.

The invention relates to the technical field of atomization rate control, in particular to an intelligent atomization compliance monitoring method and system for children. The method comprises the following steps: firstly, acquiring expiration flow velocity, inspiration flow velocity and multi-direction motion acceleration time sequence data of a child in a historical monitoring period, and reflecting breathing and behavior action conditions; dynamically analyzing the numerical characteristics of the expiration flow velocity and the inspiration flow velocity to divide a respiratory cycle, and analyzing the cycle length, the inspiration flow velocity cumulant and the like to construct a respiratory characteristic vector; screening a target monitoring period based on the breathing feature vector and the period number similarity; further analyzing the motion acceleration change and accumulation characteristics in the target monitoring period, and quantifying the behavior compliance expression degree; the behavior compliance expression degree and the breathing feature vector are deeply fused, a'breathing state-behavior cooperation 'joint evaluation model is established, the breathing and behavior states of children are dynamically recognized, the medicine atomization rate is accurately adjusted, and effective deposition of lung medicine is improved.

The utility model relates to the technical field of equipment testing, in particular to a passive following type respirator testing device and system.The device comprises a respiration simulation assembly provided with a passive following type respirator; the muscle simulation assembly is connected with the respiration simulation assembly and used for driving the respiration simulation assembly to move and simulating the expiration and inspiration exchange process of the human body based on the movement of the respiration simulation assembly; and the upper computer is communicated with the muscle simulation assembly and is used for inputting a test instruction to enable the muscle simulation assembly to move and outputting a test result of the passive following type respirator according to the test data of the passive following type respirator. Therefore, the problem that the test accuracy is low due to the fact that the simulated lung lacks a power source and the spontaneous respiration state of human muscles cannot be simulated in the prior art is solved.

The invention relates to a breathing pipeline adapter capable of adjusting the air displacement and a breathing nasal mask.The breathing pipeline adapter comprises a tubular body, a through airflow channel is formed in the tubular body, the tubular body is provided with a first end and a second end, the first end is used for being connected with nasal masks of different models, and the second end is used for being connected with an external breathing pipeline; the exhalation hole group comprises a plurality of exhalation holes, and the multiple exhalation holes are uniformly formed in the circumferential outer wall of the tubular body in an annular array mode and directly communicate with the airflow channel; the adjusting knob is coaxially arranged on the outer side of the tubular body in a sleeving mode, and a through hole is formed in the adjusting knob; the through holes can be aligned with or staggered with different numbers of exhalation holes, and the air displacement of the airflow channel is adjusted. According to the breathing nasal mask, the exhaust area can be adjusted, exhaled air can be exhausted out of the nasal mask more effectively, for a patient with a large amount of exhaled air, the effective exhaust area can be increased, the exhaled air can be exhausted in time, accumulation of the exhaled air in the nasal mask is avoided, and therefore the relapse phenomenon is reduced.

The invention relates to the technical field of medical breather pipes, in particular to an adjustable pharyngeal breather pipe which comprises a seaming opening, and a through hole is formed in the seaming opening. The gas conduit comprises a main exhaust passage and an oxygen supply interlayer, a sampling gas passage is arranged in the main exhaust passage, and oxygen flows out from an area between the oxygen supply interlayer and the main exhaust passage; the adjusting assembly comprises an impeller; the cleaning mechanism comprises a clamping plug and is used for automatically adjusting the distance between the sampling gas channel and the oxygen outlet according to the oxygen outlet flow, the larger the oxygen flow is, the larger the distance between the sampling gas channel and the oxygen outlet is, and it is avoided that too much oxygen is inhaled to affect the detection result; meanwhile, mucus and water vapor are unblocked through reciprocating movement of the clamping plug, the sampling air channel is guided through the rolling ring, meanwhile, the water vapor of exhaled air is adsorbed, and the mucus and the water vapor are prevented from blocking the air guide pipe.

The invention discloses an atmospheric environment exercise health monitoring method and system, and the method comprises the steps: S1, generating a pollution level distribution diagram based on air quality index data collected in real time, S2, determining an air quality risk value of a current region according to the pollution level distribution diagram, and S3, determining the air quality risk value of the current region according to the air quality risk value. S3, based on the air quality risk value, calculating a dynamic movement duration threshold value adaptive to human health; S4, regulating and controlling the actual movement duration of the user according to the dynamic movement duration threshold value so as to prevent pollutant inhalation from exceeding the standard; according to the atmospheric environment movement health monitoring method and monitoring system, the movement duration is regulated and controlled according to the real-time fluctuation of the air quality index, so that the problem that pollutants inhaled by the human body exceed the standard is solved.

The embodiment of the invention provides an aerosol generating product and an aerosol generating system. The aerosol generating product comprises a medium section, a functional section, a cooling section and a filter tip section which are arranged in the first direction. The draw resistance of the functional section is different from that of the medium section; the number of at least one of the functional sections and the cooling sections is two, and the functional sections and the cooling sections are located between the medium section and the filter tip section. The medium section is of an integrated structure, at least one first air channel hole is formed in the medium section, and the first air channel hole penetrates through at least one end, in the first direction, of the medium section. According to the aerosol generating product provided by the embodiment of the invention, the suction resistance of the aerosol generating product is kept in a proper range by arranging the functional sections of which the suction resistance is different from that of the medium section, and the number of the functional sections and the number of the cooling sections are controlled, so that the number of at least one of the functional sections and the cooling sections is two; the suction resistance of the aerosol generating product and the temperature of the aerosol are conveniently controlled, and the use experience of a user is improved.

The invention relates to the technical field of high-frequency breathing machines, and discloses a working method of a high-frequency breathing machine based on flow control, the high-frequency breathing machine sequentially outputs a plurality of average airway flows with the same or different sizes and the same or different action time periods according to a set period rule, and the airway flows output in an expiration phase and an inspiration phase are stable. The same or different average airway flows can be output in different inspiration phases and expiration phases; in different action time periods of the high-frequency breathing machine, the output gas flow can be periodically and independently adjusted among different ventilation flow levels; in high-frequency ventilation, the high-frequency ventilation method based on flow control can accurately control the flow and time of gas, the flow control ventilation can better control the change of airway pressure, and the air supply volume of equipment can be accurately estimated by setting proper flow and time, so that the airway pressure and risk are reduced, and the possibility of air pressure damage is reduced.

The present invention relates to a liquid pharmaceutical composition suitable for administration by inhalation comprising: (i) a suspension of particles comprising 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (RPL554); and (ii) a diluent which is 1,1,1,2-tetrafluoroethane (HFA-134a), wherein the liquid pharmaceutical composition is substantially free of surfactant. The invention also relates to a pressurised metered dose inhaler comprising the liquid pharmaceutical composition.

The invention relates to the field of surgical monitoring, in particular to a monitoring data analysis system for a surgical operation. The system firstly obtains the inspiration flow velocity and tidal volume at the current moment and each historical moment, analyzes the difference between the inspiration flow velocity at each moment and the inspiration flow velocity at each previous moment, obtains the difference degree of the inspiration flow velocity at each moment, and clusters all moments to obtain the difference degree of the inspiration flow velocity at each moment. According to the difference between the tidal volume of the current moment and the historical moment in the cluster where the current moment is located, the tidal volume difference degree of the current moment is obtained, and according to the difference between the inspiration flow speed and the historical moment and the difference between the tidal volume and the difference between the inspiration flow speed and the historical moment, the difference between the inspiration flow speed and the historical moment is obtained; according to the inspiration flow rate, the tidal volume difference degree at the current moment, the stability similarity at the current moment is obtained, and the anesthesia state of the patient is evaluated according to the inspiration flow rate, the tidal volume and the stability similarity at the current moment. The anesthesia state of the patient can be accurately evaluated, and the accuracy of anesthesia monitoring of the patient is improved.

The invention discloses a contrast agent injection regulation and control device, and relates to the technical field of contrast agent injection.The contrast agent injection regulation and control device comprises an injection pipe, one end of the injection pipe is fixedly connected with a limiting plate, a piston is slidably installed in the injection pipe, a drawing rod is installed on one side of the piston, and one end of the drawing rod is fixedly connected with a pushing piece; a limiting ring is fixedly connected to the outer portion of the drawing rod, first limiting grooves are symmetrically formed in the outer portion of the injection pipe, and an adjusting mechanism is arranged on the outer portion of the injection pipe. The position of the positioning mechanism can be changed by moving the adjusting mechanism, the scale strip is arranged outside the injection tube, the adjusting mechanism can be conveniently moved to a proper position, and when a contrast agent is sucked, due to the cooperation of the positioning mechanism and the limiting ring, the drawing rod can only move to a designated position, so that the amount of the sucked contrast agent is guaranteed, and the contrast agent suction efficiency is improved. The situation that the subsequent radiography effect is affected after too much or too little inhalation is injected into the body of a patient is avoided, and adjustment can be conveniently conducted according to the condition of the patient.