The invention belongs to the technical field of
medicine preparation, and relates to
PLGA gel used as an injectable long-acting
local anesthesia medicine as well as application and a preparation method of the
PLGA gel. The
PLGA gel comprises the PLGA gel which is loaded with superparamagnetic Fe3O4 particles and a
small molecule local anesthetic, namely, levobupivacaine (Levobupi). The PLGA hydrogel containing Fe3O4 and levobupivacaine can be used as an injectable long-acting
local anesthesia medicine, and the hydrogel can be changed from liquid to
solid after being injected into a
living body, so that the release efficiency of the medicine is slowed down, and the local action time of the hydrogel is prolonged. In addition, the hydrogel can undergo a
phase change from a
solid state to a
liquid state under magnetocaloric therapy (MHT), increase
pore diameter, promote release of levobupivacaine, and provide enhanced
pain relief in vivo. Compared with the prior art, the invention has the beneficial effects of simple synthesis and easy industrialization. The
drug release rate is adjusted through the
phase change of the hydrogel, super-long-acting analgesia is realized, and the analgesia time is gt; 20 days. The gel can be loaded with various
local anesthesia drugs such as L-
bupivacaine, and
pain management can be carried out on various pain scenes clinically.