53 results about "Acute pain" patented technology

The present invention relates to novel pharmaceutical composition comprising meloxicam for the treatment of acute pain, wherein the composition comprises at least a hydrophilic polymer and one or more alkalizing agents or combinations thereof.

The present invention relates to novel pharmaceutical composition comprising meloxicam for the treatment of acute pain, wherein the composition comprises at least a hydrophilic polymer and one or more alkalizing agents or combinations thereof.

The present invention relates to novel pharmaceutical composition comprising meloxicam for the treatment of acute pain, wherein the composition comprises at least a hydrophilic polymer and one or more alkalizing agents or combinations thereof.

The present invention relates to a voltage-gated sodium channel Nav1.8 selective inhibitor and the use thereof in the preparation of a related drug. The drug is used for treating diseases responsive to the inhibition of voltage-gated sodium channel NaV1.8, such as chronic pain, enterodynia, neuropathic pain, musculoskeletal pain, acute pain, inflammatory pain, cancer pain, idiopathic pain, post-operative pain, visceral pain, multiple sclerosis, Charcot-Marie-Tooth syndrome, incontinence, pathological cough or arrhythmia. Specifically, the present invention relates to a compound as shown in formula (X), and an isomer, nitrogen oxide, hydrate, solvate, metabolite, pharmaceutically acceptable salt or prodrug thereof.

The invention provides a novel analgesic injection composition. The composition comprises tapentadol in an active ingredient quick release form and a quick-acting and long-acting composition of bistapentadol sebacate in an active ingredient slow release form. The invention also relates to a method for preparing the quick-acting and long-acting injection composition and application of the prepared dosage form in preparation of medicines for treating chronic or acute pain, such as preoperative and postoperative administration. The quick-acting and long-acting injection composition provided by the invention has ideal pharmaceutical technology and clinical attributes.

The present invention is directed to novel compounds that inhibit Nav1.8 sodium channels, methods of making, and methods of using thereof. The present disclosure is further directed to administering the disclosed compounds as therapeutic solutions for chronic pain, primary pain, idiopathic pain, gastrointestinal pain, neuropathic pain, musculoskeletal pain, acute pain, inflammatory pain, cancer-related pain, idiopathic pain, postoperative pain, visceral pain, multiple sclerosis, Summer-Marr-Tuff syndrome, incontinence, pathological cough, or arrhythmia to a subject in need thereof.

The invention belongs to the field of human body detection devices, and provides a wearable system for evaluating pain, which comprises wearable equipment in communication connection with a cloud system. The wearable device is used for continuously collecting physiological signals when a patient wears the wearable device. The cloud system is provided with a hierarchical evaluation module, a correction module and an intervention control module, the hierarchical evaluation module extracts physiological features in a long-term time window, extracts skin electroreaction mutation, a myoelectricity activity peak value and skin temperature rapid change in a short-term time window, and deduces an acute pain level in combination with instant self-evaluation information of a patient; the correction module is used for correcting the acute score based on the mapping relation between the long-term stability characteristic and the acute pain level and an individualized threshold value; the intervention control module generates individualized electrical stimulation control parameters according to the correction result and issues the individualized electrical stimulation control parameters to the wearable device, and the electrical stimulation execution unit outputs a stimulation signal through the percutaneous electrode to relieve pain of the patient and uploads a feedback signal to the cloud end to form a closed loop.

The invention relates to the technical field of signal analysis, in particular to an acute pain assessment method and system based on an EDA signal, and the method comprises the following steps: collecting a skin electrical activity EDA signal of a subject; calculating an individual time-varying sympathetic nerve activity TVSymp curve; the method comprises the following steps: constructing a priori knowledge base containing a standardized pain response sympathetic nerve SpainSymp template; inputting the EDA signal and the individual TVSymp curve into a PCVAE model, fusing features and decoupling the features into pain common features and individual specific features; carrying out pain intensity classification, and reconstructing and generating a standardized SpainSymp curve of which individual specific characteristics are removed; and outputting the pain intensity classification result and the dynamic change trend of the standardized SpainSymp curve in real time. By adopting the method, the pain-induced physiological reaction and individual baseline variation can be effectively decoupled and separated from the mixed EDA signal, the interference of individual difference is avoided, and the method has the characteristics of high accuracy and strong real-time performance.

The invention provides a preparation method and application of graphene pain-relieving health-care paste, and the method comprises the following steps: mixing carrageenan with water to obtain a carrageenan solution, and carrying out ionization degradation on the carrageenan solution to obtain a carrageenan oligosaccharide solution; the preparation method comprises the following steps: stirring graphene oxide and a carrageenan oligosaccharide solution, cleaning to obtain a mixed solution, adding sodium alginate into the mixed solution to prepare a gel precursor, and adding an anhydrous calcium chloride solution and effective components into the gel precursor to obtain the pain-relieving gel, and drying the gel to obtain the health-care paste. The health-care ointment has the effects of promoting blood circulation, activating collaterals and inhibiting inflammation, and is suitable for various chronic pains such as rheumatic arthritis and lumbar muscle degeneration and acute pains such as traumatic injury and muscle strain; the composition is also suitable for auxiliary relieving of postoperative pain, and has safety and long-term effect. Due to the thermal conductivity of the graphene oxide in the health-care cream, local skin blood circulation can be accelerated, the permeation efficiency of the herbal extract is improved, and the medicine effect of the effective components is improved.

The present invention relates to modulators of TNF signalling for use in treating and / or preventing acute pain. In particular, a modulator of TNF signalling may be a tumour necrosis factor receptor 2 (TNFR2) agonist comprising (i) a TNFR2 binding domain comprising three TNF homology domains (THD) that specifically bind to TNFR2; and (ii) an Fc domain. The present invention further relates to combinations of a TNFR2 agonist and an inhibitor of tumour necrosis factor receptor 1 (TNFR1) signalling.

The present invention provides: a novel heteroaryl derivative compound, a hydrate thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating AAK1 inhibition-related diseases, the composition comprising same as an active ingredient. The heteroaryl derivative compound according to the present invention exhibits excellent inhibitory activity against AAK1, and thus can be effectively used for preventing and treating AAK1 inhibition-related diseases such as acute pain and neuropathic pain.

The present invention belongs to the technical field of pain relief preparations, and particularly relates to a pain relief preparation, a preparation method thereof and an application. The pain relief preparation is composed of (+)-camphene, a propylene glycol extract of Bupleurum chinense DC. and pharmaceutically acceptable excipients. Among them, the mass ratio of (+)-camphene to the propylene glycol extract of Bupleurum chinense DC. is 1-2.5:1. The propylene glycol extract of Bupleurum chinense DC. is prepared by the following method: Bupleurum chinense DC. is ground into powder, mixed with propylene glycol, extracted by ultrasonic treatment, filtered, the filtrate is collected and dried to obtain the propylene glycol extract of Bupleurum chinense DC. The present invention also provides a preparation method of the pain relief preparation, and proves the application of the pain relief preparation in relieving acute pain and postherpetic neuralgia, expanding the types of pain relief preparations.

The invention relates to a postoperative acute pain prediction method, belongs to the technical field of medical data analysis and processing, and solves the problem of insufficient postoperative acute pain prediction precision in the prior art. The method comprises the following steps: acquiring multi-omics data and clinical data of a to-be-predicted patient; constructing a primary network of each omics based on the anchor point molecules of each omics; the second-level network and each later-level network are obtained by expanding the previous-level network based on the molecular interaction relationship; taking each level of network as a multi-level molecular interaction network of the to-be-predicted patient; adopting a trained deep learning model to extract high-dimensional biological characteristics of a to-be-predicted patient based on the multistage molecular interaction network; and predicting the pain type of the to-be-predicted patient based on the high-dimensional biological characteristics, the multi-omics data and the clinical data. And the accuracy of postoperative acute pain prediction is improved.

A method and system for differentiating acute and chronic pain based on the functional state of specific neural circuits is proposed. This method utilizes in vivo two-photon / endoscopic calcium imaging and ex vivo brain slice patch-clamp techniques to longitudinally monitor the activity dynamics of neurons in the DRN and ZI brain regions during the acute and chronic phases of a neuropathic pain model. By extracting and analyzing calcium and electrophysiological signal parameter sets, distinguishing criteria are established: if the activity of 5-HTergic neurons in the DRN is specifically enhanced in the acute phase, the indication is acute pain; if the activity of GABAergic neurons in the ZI is specifically enhanced in the chronic phase, the indication is chronic pain. This invention achieves an objective and precise differentiation of the transition from acute to chronic pain at the level of specific neural circuits, providing a new strategy and tool for pain mechanism research and clinical diagnosis and treatment.

The application provides an electroencephalogram pain positioning device, a training method and equipment, and constructs an electroencephalogram pain positioning device including a preprocessing module, a double-branch space-time coding backbone network, a mixed expert-weight decomposition low-rank adaptation module and a detection head. The double-branch space-time coding backbone network includes a coarse-grained branch for extracting low-frequency global features of electroencephalogram signals and a fine-grained branch for extracting high-frequency transient detail features of electroencephalogram signals. In this way, the transient high-frequency features of acute pain and the continuous low-frequency oscillation features of chronic pain can be captured at the same time, and the problem that a single scale network cannot consider the dynamic characteristics of different pain types is solved.

A group of marker sets capable of effectively predicting acute pain of a patient after cesarean section is screened out, and the marker sets comprise whether the patient has preoperative anxiety or not, whether the patient is gestational diabetes mellitus or not, the age of the patient, the Pittsburgh sleep quality index (PSQI) of the patient, the gestational week age of the patient and the abdominal circumference of the patient. On the basis, a visual and quantifiable column diagram prediction model is constructed, the method can be used for evaluating the risk probability of acute pain occurring after a cesarean section patient is operated clinically before an operation, targeted and individualized pain management is provided for the patient subsequently, the pregnancy safety of the patient is improved, and physical and psychological pain of the patient after the operation is relieved.

The present invention relates to a method for managing pain, such as acute pain, post-operative pain, or post-procedure pain, by administering meloxicam.

The invention discloses oligopeptide and application thereof in preparation of a medicine for treating and / or relieving pain. The amino acid sequence of the oligopeptide disclosed by the invention comprises a derivative sequence formed by additionally arranging 1-3 amino acids at the N end and / or C end of the amino acid sequence shown as Tyr-Pro-Arg, especially Tyr-Pro-Arg-Arg (YPRR, YR4), and a gastrointestinal tract digestion product Tyr-Pro-Arg (YPR, YR3) of the oligopeptide. The oligopeptide not only can relieve acute pain induced by a mouse thermal drifting model, but also can relieve chronic pain induced by a rat sciatic nerve chronic compression injury model and a tibia bone cancer pain model, and meanwhile, the oligopeptide obviously inhibits CCI-induced spinal astrocyte, microglia and neuron activation; therefore, the compound has important development and application values in the aspects of central sensitization inhibition and analgesia.

The invention provides an electroencephalogram pain positioning device, a training method and equipment, and constructs the electroencephalogram pain positioning device comprising a preprocessing module, a double-branch space-time coding backbone network, a hybrid expert-weight decomposition low-rank adaptation module and a detection head. The double-branch space-time coding backbone network comprises a coarse-grained branch used for extracting low-frequency global features of the electroencephalogram signals and a fine-grained branch used for extracting high-frequency transient detail features of the electroencephalogram signals, so that transient high-frequency features of acute pain and continuous low-frequency oscillation features of chronic pain can be captured at the same time, and the accuracy of the transient high-frequency features of the acute pain and the continuous low-frequency oscillation features of the chronic pain can be improved. The problem that a single-scale network cannot give consideration to dynamic characteristics of different pain types is solved.

This invention discloses a novel class of monoacylglycerol lipase (MAGL) small molecule inhibitors, as well as their pharmaceutically acceptable compositions, methods of preparation, and uses. The MAGL small molecule inhibitors are represented by formula (I), having the specific substituents and definitions described herein. The disclosed MAGL small molecule inhibitors exhibit excellent MAGL enzyme inhibitory activity. This invention includes these compounds or their pharmaceutically acceptable compositions for the treatment and / or prevention of MAGL-related conditions such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, neurotoxicity, stroke, epilepsy, anxiety, migraine, depression, hepatocellular carcinoma, colorectal cancer lesions, ovarian cancer, neuropathic pain, chemotherapy-induced neuropathy, acute pain, chronic pain, and / or pain-related spasticity.

The invention relates to aqueous, oral formulations of diclofenac that provide both rapid and sustained relief from acute pain. The invention further relates to pharmaceutical compositions comprising the compounds, methods of making the aqueous pharmaceutical compositions and methods of using the compounds treating pain, including, but not limited to migraines.

The invention provides a transdermal analgesic patch as well as a preparation method and application thereof. The transdermal analgesic patch consists of a polyethylene glycol terephthalate backing layer, a drug-containing gel layer and a silicified polyester anti-sticking layer. The medicine-containing gel layer takes diclofenac sodium, menthol and capsaicin as analgesic active ingredients according to a specific proportion, and raw materials such as a laurocapram and L-menthol compound penetration enhancer, a blending pressure-sensitive adhesive matrix and a compound antioxidant are matched. The preparation method comprises the steps of dissolving, mixing, coating, drying, compounding and the like, and the process is mild and controllable. The patch is excellent in transdermal performance, the steady-state transdermal rate reaches up to 38.3 micrograms / cm < 2 > h, the 24-hour analgesic total effective rate is 93.3%, and the patch is good in stability and free of layering and curling problems. The traditional Chinese medicine composition can be used for preparing medicines for treating postoperative acute pain or chronic neuropathic pain, and is convenient to use and stable in effect.

The present disclosure relates to oxazolidone-derived compounds (of formulas I, II, III and IV) and their use as pharmaceutical agent in the treatment, prevention or reduction of both acute and chronic pain. The mode of action disclosed herein allows oxazolidone and oxazolidone analogue compounds to act as analgesic through reduction of hyperactive firing of pain sensing neurons. Related to their high efficacy in the treatment of pain, these compounds are expected to selectively target voltage-activated K+ currents expressed in the small diameter dorsal root neurons (sdDRGns). Such findings, together with those showing that oxazolidone and oxazolidone analogue compounds act as activity dependent blockers also lead to very reduced side-effects. The results disclosed herein show that oxazolidone and oxazolidone analogue compounds described herein are a viable alternative to the already existing pharmaceutical compounds used in the treatment of pain.

The invention discloses a long-acting analgesic medicine for anterior saw muscle plane block and application of the long-acting analgesic medicine, and relates to the technical field of biological pharmacy, the long-acting analgesic medicine for anterior saw muscle plane block comprises ropivacaine and methylene blue, the concentration of the ropivacaine is 0.5-1.0%, the concentration of the methylene blue is 0.5-1.0%, and the concentration of the methylene blue is 0.5-1.0%. The concentration of the methylene blue is 0.5%-2.0%; the medicine is used for anterior saw muscle plane block after prosthetic breast augmentation. It is clear for the first time that compared with independent use of ropivacaine, when methylene blue and ropivacaine are used in anterior saw muscle plane block, acute pain in the hospitalization period of prosthetic breast augmentation can be effectively relieved, a stable analgesic effect is provided within 72 hours after an operation, and long-acting analgesia can be achieved; the analgesic medicine has the advantage of low cost; the addition of methylene blue does not increase the occurrence rate of adverse reactions, and the method has good safety and wide application potential.

The utility model discloses a fitting type ice compress tool for relieving acute pain of gouty arthritis, which comprises a pre-fixing belt, and an ice compress component is arranged on the pre-fixing belt; the ice compress assembly comprises a cloth bag, an ice compress bag is placed in the cloth bag, a connecting belt is fixedly connected to one side of the cloth bag, a plurality of hooks are fixedly connected to the connecting belt, and a sponge mat is fixedly connected to the fixing belt. According to the utility model, the pre-fixing belt is arranged to be matched with the ice compress assembly, so that a patient can firstly fix the pre-fixing belt near an affected part in a daily state, when the joint has obvious pain, the ice compress bag is taken out and put into the cloth bag, the part of the connecting belt with the hook is pressed on the sponge cushion, and the connecting belt slides upwards to enable the hook to be clamped into the clamping ring, so that the ice compress bag is fixed to the affected part. And then the drawstring penetrates through the connecting pipe, and then the magic tapes on the drawstring are adhered together, so that the ice compress operation can be completed, and the mode is simple to operate and convenient to use.

The present disclosure relates to oxazolidone-derived compounds (of formulas I, II, III and IV) and their use as pharmaceutical agent in the treatment, prevention or reduction of both acute and chronic pain. The mode of action disclosed herein allows oxazolidone and oxazolidone analogue compounds to act as analgesic through reduction of hyperactive firing of pain sensing neurons. Related to their high efficacy in the treatment of pain, these compounds are expected to selectively target voltage-activated K+ currents expressed in the small diameter dorsal root neurons (sdDRGns). Such findings, together with those showing that oxazolidone and oxazolidone analogue compounds act as activity dependent blockers also lead to very reduced side-effects. The results disclosed herein show that oxazolidone and oxazolidone analogue compounds described herein are a viable alternative to the already existing pharmaceutical compounds used in the treatment of pain.

The invention discloses a microneedle patch for preventing and treating gouty arthritis and a preparation method of the microneedle patch, and belongs to the technical field of biological medicines. The microneedle patch is composed of a microneedle array and a backing. The microneedle array is prepared from the following raw materials: a polymer, an analgesic anti-inflammatory drug, a uric acid reducing drug and a crystal inhibitor; the polymer is composed of a water-insoluble polymer and an amphiphilic water-soluble polymer. The analgesic anti-inflammatory drug, the uric acid reducing drug and the crystal inhibitor are creatively loaded into the microneedle patch together, and the microneedle patch for preventing and treating gouty arthritis based on a solid dispersion technology is successfully developed by combining hot melt extrusion with a hot pressing method; the prepared microneedle patch is good in mechanical property, can realize a strategy for synergistically preventing and treating gouty arthritis in three aspects of rapidly easing pain, resisting inflammation and relieving acute pain, inhibiting sodium urate crystallization to prevent further induced inflammatory storm and slowly reducing the uric acid level and reducing the administration frequency, and enhances the curative effect.

Disclosed herein, inter alia, are methods of treating pain by administering compositions that include at least one purified free amino acid, at least one purified fatty acid, and a purified fatty acid amide, related compositions, and kits thereof.

The application discloses application of anterior piriform cortex GABAergic neurons as an analgesic target point, and relates to the technical field of neuroscience and pain. GABA The application discloses that the neural loop (APC GABA →MD) from the anterior piriform cortex GABAergic neurons to the thalamic dorsal medial nucleus plays a key role in pain regulation. Experiments prove that the loop can not only relieve acute pain, but also has a significant analgesic effect on the clinical treatment of intractable chronic inflammatory pain and neuropathic pain models, and shows a wide treatment application prospect.