21 results about "Acute pain" patented technology

The invention relates to the technical field of signal analysis, in particular to an acute pain assessment method and system based on an EDA signal, and the method comprises the following steps: collecting a skin electrical activity EDA signal of a subject; calculating an individual time-varying sympathetic nerve activity TVSymp curve; the method comprises the following steps: constructing a priori knowledge base containing a standardized pain response sympathetic nerve SpainSymp template; inputting the EDA signal and the individual TVSymp curve into a PCVAE model, fusing features and decoupling the features into pain common features and individual specific features; carrying out pain intensity classification, and reconstructing and generating a standardized SpainSymp curve of which individual specific characteristics are removed; and outputting the pain intensity classification result and the dynamic change trend of the standardized SpainSymp curve in real time. By adopting the method, the pain-induced physiological reaction and individual baseline variation can be effectively decoupled and separated from the mixed EDA signal, the interference of individual difference is avoided, and the method has the characteristics of high accuracy and strong real-time performance.

The present invention relates to modulators of TNF signalling for use in treating and / or preventing acute pain. In particular, a modulator of TNF signalling may be a tumour necrosis factor receptor 2 (TNFR2) agonist comprising (i) a TNFR2 binding domain comprising three TNF homology domains (THD) that specifically bind to TNFR2; and (ii) an Fc domain. The present invention further relates to combinations of a TNFR2 agonist and an inhibitor of tumour necrosis factor receptor 1 (TNFR1) signalling.

The invention relates to a postoperative acute pain prediction method, belongs to the technical field of medical data analysis and processing, and solves the problem of insufficient postoperative acute pain prediction precision in the prior art. The method comprises the following steps: acquiring multi-omics data and clinical data of a to-be-predicted patient; constructing a primary network of each omics based on the anchor point molecules of each omics; the second-level network and each later-level network are obtained by expanding the previous-level network based on the molecular interaction relationship; taking each level of network as a multi-level molecular interaction network of the to-be-predicted patient; adopting a trained deep learning model to extract high-dimensional biological characteristics of a to-be-predicted patient based on the multistage molecular interaction network; and predicting the pain type of the to-be-predicted patient based on the high-dimensional biological characteristics, the multi-omics data and the clinical data. And the accuracy of postoperative acute pain prediction is improved.

A method and system for differentiating acute and chronic pain based on the functional state of specific neural circuits is proposed. This method utilizes in vivo two-photon / endoscopic calcium imaging and ex vivo brain slice patch-clamp techniques to longitudinally monitor the activity dynamics of neurons in the DRN and ZI brain regions during the acute and chronic phases of a neuropathic pain model. By extracting and analyzing calcium and electrophysiological signal parameter sets, distinguishing criteria are established: if the activity of 5-HTergic neurons in the DRN is specifically enhanced in the acute phase, the indication is acute pain; if the activity of GABAergic neurons in the ZI is specifically enhanced in the chronic phase, the indication is chronic pain. This invention achieves an objective and precise differentiation of the transition from acute to chronic pain at the level of specific neural circuits, providing a new strategy and tool for pain mechanism research and clinical diagnosis and treatment.

The application provides an electroencephalogram pain positioning device, a training method and equipment, and constructs an electroencephalogram pain positioning device including a preprocessing module, a double-branch space-time coding backbone network, a mixed expert-weight decomposition low-rank adaptation module and a detection head. The double-branch space-time coding backbone network includes a coarse-grained branch for extracting low-frequency global features of electroencephalogram signals and a fine-grained branch for extracting high-frequency transient detail features of electroencephalogram signals. In this way, the transient high-frequency features of acute pain and the continuous low-frequency oscillation features of chronic pain can be captured at the same time, and the problem that a single scale network cannot consider the dynamic characteristics of different pain types is solved.

A group of marker sets capable of effectively predicting acute pain of a patient after cesarean section is screened out, and the marker sets comprise whether the patient has preoperative anxiety or not, whether the patient is gestational diabetes mellitus or not, the age of the patient, the Pittsburgh sleep quality index (PSQI) of the patient, the gestational week age of the patient and the abdominal circumference of the patient. On the basis, a visual and quantifiable column diagram prediction model is constructed, the method can be used for evaluating the risk probability of acute pain occurring after a cesarean section patient is operated clinically before an operation, targeted and individualized pain management is provided for the patient subsequently, the pregnancy safety of the patient is improved, and physical and psychological pain of the patient after the operation is relieved.

The present invention relates to a method for managing pain, such as acute pain, post-operative pain, or post-procedure pain, by administering meloxicam.

The invention provides an electroencephalogram pain positioning device, a training method and equipment, and constructs the electroencephalogram pain positioning device comprising a preprocessing module, a double-branch space-time coding backbone network, a hybrid expert-weight decomposition low-rank adaptation module and a detection head. The double-branch space-time coding backbone network comprises a coarse-grained branch used for extracting low-frequency global features of the electroencephalogram signals and a fine-grained branch used for extracting high-frequency transient detail features of the electroencephalogram signals, so that transient high-frequency features of acute pain and continuous low-frequency oscillation features of chronic pain can be captured at the same time, and the accuracy of the transient high-frequency features of the acute pain and the continuous low-frequency oscillation features of the chronic pain can be improved. The problem that a single-scale network cannot give consideration to dynamic characteristics of different pain types is solved.

This invention discloses a novel class of monoacylglycerol lipase (MAGL) small molecule inhibitors, as well as their pharmaceutically acceptable compositions, methods of preparation, and uses. The MAGL small molecule inhibitors are represented by formula (I), having the specific substituents and definitions described herein. The disclosed MAGL small molecule inhibitors exhibit excellent MAGL enzyme inhibitory activity. This invention includes these compounds or their pharmaceutically acceptable compositions for the treatment and / or prevention of MAGL-related conditions such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, neurotoxicity, stroke, epilepsy, anxiety, migraine, depression, hepatocellular carcinoma, colorectal cancer lesions, ovarian cancer, neuropathic pain, chemotherapy-induced neuropathy, acute pain, chronic pain, and / or pain-related spasticity.

The invention provides a transdermal analgesic patch as well as a preparation method and application thereof. The transdermal analgesic patch consists of a polyethylene glycol terephthalate backing layer, a drug-containing gel layer and a silicified polyester anti-sticking layer. The medicine-containing gel layer takes diclofenac sodium, menthol and capsaicin as analgesic active ingredients according to a specific proportion, and raw materials such as a laurocapram and L-menthol compound penetration enhancer, a blending pressure-sensitive adhesive matrix and a compound antioxidant are matched. The preparation method comprises the steps of dissolving, mixing, coating, drying, compounding and the like, and the process is mild and controllable. The patch is excellent in transdermal performance, the steady-state transdermal rate reaches up to 38.3 micrograms / cm < 2 > h, the 24-hour analgesic total effective rate is 93.3%, and the patch is good in stability and free of layering and curling problems. The traditional Chinese medicine composition can be used for preparing medicines for treating postoperative acute pain or chronic neuropathic pain, and is convenient to use and stable in effect.

The present disclosure relates to oxazolidone-derived compounds (of formulas I, II, III and IV) and their use as pharmaceutical agent in the treatment, prevention or reduction of both acute and chronic pain. The mode of action disclosed herein allows oxazolidone and oxazolidone analogue compounds to act as analgesic through reduction of hyperactive firing of pain sensing neurons. Related to their high efficacy in the treatment of pain, these compounds are expected to selectively target voltage-activated K+ currents expressed in the small diameter dorsal root neurons (sdDRGns). Such findings, together with those showing that oxazolidone and oxazolidone analogue compounds act as activity dependent blockers also lead to very reduced side-effects. The results disclosed herein show that oxazolidone and oxazolidone analogue compounds described herein are a viable alternative to the already existing pharmaceutical compounds used in the treatment of pain.

The utility model discloses a fitting type ice compress tool for relieving acute pain of gouty arthritis, which comprises a pre-fixing belt, and an ice compress component is arranged on the pre-fixing belt; the ice compress assembly comprises a cloth bag, an ice compress bag is placed in the cloth bag, a connecting belt is fixedly connected to one side of the cloth bag, a plurality of hooks are fixedly connected to the connecting belt, and a sponge mat is fixedly connected to the fixing belt. According to the utility model, the pre-fixing belt is arranged to be matched with the ice compress assembly, so that a patient can firstly fix the pre-fixing belt near an affected part in a daily state, when the joint has obvious pain, the ice compress bag is taken out and put into the cloth bag, the part of the connecting belt with the hook is pressed on the sponge cushion, and the connecting belt slides upwards to enable the hook to be clamped into the clamping ring, so that the ice compress bag is fixed to the affected part. And then the drawstring penetrates through the connecting pipe, and then the magic tapes on the drawstring are adhered together, so that the ice compress operation can be completed, and the mode is simple to operate and convenient to use.

The application discloses application of anterior piriform cortex GABAergic neurons as an analgesic target point, and relates to the technical field of neuroscience and pain. GABA The application discloses that the neural loop (APC GABA →MD) from the anterior piriform cortex GABAergic neurons to the thalamic dorsal medial nucleus plays a key role in pain regulation. Experiments prove that the loop can not only relieve acute pain, but also has a significant analgesic effect on the clinical treatment of intractable chronic inflammatory pain and neuropathic pain models, and shows a wide treatment application prospect.

The application relates to the technical field of signal analysis, in particular to an acute pain evaluation method and system based on EDA signals, which comprises the following steps: collecting electrodermal activity (EDA) signals of a subject; calculating an individual time-varying sympathetic nerve activity (TVSymp) curve; constructing a priori knowledge base containing a standardized pain response sympathetic nerve (SPainSymp) template; inputting the EDA signals and the individual TVSymp curve into a PCVAE model, fusing features and decoupling into pain common features and individual specific features; performing pain intensity classification, and reconstructing a standardized SPainSymp curve by removing individual specific features; and outputting the pain intensity classification result and the dynamic change trend of the standardized SPainSymp curve in real time. The method can effectively decouple and separate the physiological response induced by pain from the individual baseline variation from the mixed EDA signals, and is not interfered by individual differences, and has the characteristics of high accuracy and strong real-time performance.

The invention belongs to the technical field of medicines, and discloses an application of esketamine in relieving delirium of burn patients after general anesthesia, which is characterized in that a sub-anesthetic amount esketamine load dose is given to the patients who are selectively subjected to burn scab excision skin grafting after general anesthesia induction and before the operation is started, so that the delirium of the patients after general anesthesia can be relieved, and the delirium of the patients after general anesthesia can be relieved. During the operation, intravenous infusion is continuously performed to maintain the dosage to 30 minutes before the operation is finished, so that the occurrence rate and severity of delirium of a patient within 7 days after the operation can be effectively reduced, meanwhile, acute pain after the operation is improved, the consumption of opioid drugs in the perioperative period is reduced, the sleep quality after the operation is improved, the occurrence rate of untoward effects is not obviously increased, and the safety is good. The invention provides a safe and effective new means for clinical application, and has important clinical application value.

The present disclosure relates to chemical compositions and methods for treating pain, including osteoarthritis pain. The composition comprises a group of TRPV1 ion channel modulator derivatives, including capsaicin derivatives, which can be covalently linked to a polymer. The disclosed TRPV1 ion channel modulator derivatives are covalently linked to a polymer, and alternatively or additionally, the ion channel modulator derivatives are mixed with a polymer. Also disclosed are methods of treating pain using the disclosed compounds via injection into or near a pain site. The disclosed compositions and methods are advantageous in that they exhibit sustained release of TRPV1 ion channel modulators, mitigate initial acute pain associated with TRPV1 modulators, and can be used at high concentrations, thereby effectively treating pain, including osteoarthritis knee joint pain.

The invention provides an umbilicus application suppository for treating dysmenorrhea and a preparation method thereof, and relates to the technical field of medicines.The umbilicus application suppository for treating dysmenorrhea comprises a suppository body, and the suppository body comprises a suppository matrix, an emulsified oil phase, an emulsified water phase, an emulsifier and a traditional Chinese medicine composition, the traditional Chinese medicine composition comprises astragalus membranaceus, ginseng, angelica sinensis, radix paeoniae alba, cassia twig, rhizoma zingiberis, fructus cnidii, herba epimedii, salvia miltiorrhiza, leonurus, ligusticum wallichii and curcuma zedoary. By designing the suppository containing the specific traditional Chinese medicine composition and the emulsification system, the medicine permeability and bioavailability can be effectively improved, so that acute pain attack is rapidly relieved, the skin allergy risk is reduced, long-acting conditioning is performed on dysmenorrhea roots such as cold in uterus and blood stasis, and the curative effect is good. The traditional Chinese medicine composition has the advantages of quickly relieving dysmenorrhea symptoms, improving medicine permeability, reducing skin irritation response and comprehensively conditioning dysmenorrhea pathogenesis.

Neuromodulation devices and methods of their use are described in which a therapeutic device is configured to generate a treatment for treating pain such as the reduction of the symptoms of chronic and acute pain as well as for treating other conditions. The neuromodulation device generates an output electrical signal in the form of pulses with a fast rise-time spike waveform followed by a longer-duration, lower amplitude primary phase waveform. The output signal includes a broad range of frequency components, with time constants tuned so as to interact with specific cell membrane or cellular components. The output signal may be conducted to the patient via electrodes. The pulses are triggered at variable intervals which prevent habituation.

Described herein are unit oral dose compositions that reduce the severity of heartburn and / or upset stomach or the risk of the occurrence of heartburn and / or upset stomach in a human in need of taking ibuprofen or the pharmaceutically acceptable salt thereof for the treatment of acute pain wherein the human is not experiencing heartburn and / or upset stomach prior to the oral administration of the unit oral dose composition comprising orally administering to the human of a unit oral dose composition comprising (i) ibuprofen or the pharmaceutically acceptable salt thereof, wherein the amount of ibuprofen or the conjugate base of ibuprofen of the pharmaceutically acceptable salt of ibuprofen is a dosage from about 50 mg to about 400 mg per unit oral dose composition and (ii) famotidine or the pharmaceutically acceptable salt thereof, wherein famotidine or the conjugate acid of famotidine of the pharmaceutically acceptable salt of famotidine is at a dosage from about 3 mg to about 20 mg per unit oral dose composition, wherein the dissolution rate of famotidine or the conjugate acid of famotidine of the pharmaceutically acceptable salt of famotidine in the unit oral dose composition in said human at a specified time within 45 minutes of administration of said unit oral dose composition to said human is greater than the dissolution rate of ibuprofen or the conjugate base of ibuprofen of the pharmaceutically acceptable salt of ibuprofen in the unit oral dose composition in said human at the same specified time.

In one or more embodiments, the present invention provides a system for local drug delivery using electrospun poly(ester urea) nanofibers to rapidly deliver local pain killers, NSAIDs and / or other local analgesics to injury sites. These drug-loaded poly(ester urea) (PEU) nanofibers provides acute pain relief, preserves patient mobility, and reduces risk of central sensitization. These drug-loaded poly(ester urea) (PEU) nanofibers are made using a bicarbonate as an additive during the electrospinning process, thereby increasing the porosity, and with it the surface-to-volume ratio, of the spun fibers nanofibers. It has been found, unexpectedly, that use of the sodium bicarbonate additive can double or even triple the amount of the drug that can be delivered. Further, by controlling the molecular weight of the PEU polymer, the diameter of the nanofibers, and the type and / or amount of additive being used, the drug release kinetics can be tuned.