77 results about "Patient compliance" patented technology

The application discloses a traditional Chinese medicine composition for treating pregnancy embryo residue, a preparation method and application thereof and a pharmaceutical preparation, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following components: Astragalus membranaceus, Angelica sinensis, Ligusticum chuanxiong, Sparganium stoloniferum, Curcuma zedoaria, Semen Persicae, Herba impatiens, Radix Trichosanthis, Solpugid and Motherwort. Clinical efficacy observation shows that the traditional Chinese medicine composition can effectively promote the discharge of residual tissue, avoid the operation of a palace cleaning operation, shorten the time of vaginal bleeding, promote the repair of endometrium, and has good patient compliance and good tolerance, and no serious adverse reactions are found, and the effective rate is more than 90%. The traditional Chinese medicine composition is based on the theory of monarch, minister and assistant in traditional Chinese medicine, and the components are matched with each other, so that an excellent use effect is achieved.

The application provides a non-contact pain monitoring mattress and system based on multi-modal physiological signal fusion, the mattress body comprises, from bottom to top, a bottom support layer, a signal shielding layer, a sensing core layer and a breathable skin-friendly layer, the system comprises the non-contact pain monitoring mattress, a low-noise charge amplifier, a fiber demodulator, an edge computing gateway and a cloud analysis center, the data after signal conditioning is transmitted to the edge computing gateway and uploaded to the cloud analysis center, and the cloud analysis center performs quantitative scoring through a tumor-specific pain model.The application has the advantages that no electrode or wearable device needs to be pasted, the skin irritation and psychological burden of traditional monitoring are completely eliminated, the patient compliance is improved, the limitation of subjective evaluation is broken through, an objective pain evaluation method is provided for patients in the late stage / aphasia, multi-modal signal fusion monitoring is used to effectively distinguish pain from ordinary emotional fluctuations, the degree of pain is fed back in real time, the doctor is assisted in dynamically adjusting the dose of analgesic drugs, and the risk of drug overdose and deficiency is reduced.

This invention discloses the application of reagents for detecting biomarker levels in the preparation of products for identifying obstructive sleep apnea. It relates to the field of biomarker technology and aims to overcome the shortcomings of existing technologies that rely on complex polysomnography (PSG) procedures, poor patient compliance, and a lack of effective molecular markers. The biomarkers used in this application consist of CD36 glycoprotein, 9-octadecenal, and protocatechuic acid 3-O-sulfate. This invention enables rapid and objective identification of obstructive sleep apnea by detecting the levels of the above biomarkers in plasma. The procedure is simple and well-accepted by patients. The combined use of multiple biomarkers can improve the accuracy and stability of the identification, making it suitable for screening or auxiliary diagnosis in medical institutions at different levels.

“Artificial Intelligence” or “AI” technology can be applied to Wearable Cardioverter Defibrillators (“WCDs”) and other wearable medical equipment in various ways, including garment fitting and adjustment, analyzing electrocardiogram (“ECG”), other sensor data and / or other patient data in real time to detect / assess the patient's present condition and / or need for treatment for cardiac and other conditions (e.g., stroke, coughing, apnea, etc.), detect imminent failure of the wearable medical device components, capture and report data collected from the patient for presenting to clinicians, adjust thresholds for alarms and notifications based on patient's responses, improve patient compliance based on the patient's past non-compliant behavior and actions that resulted in the patient becoming compliant, provide tests to the patient, and learn the patient's responses to detect / assess the patient's present condition and / or need for treatment.

The application provides a traditional Chinese medicine composition for treating anorectal diseases and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition provided by the application uses specific plant juice as a penetration-promoting and soothing component, significantly improves the penetration speed and absorption efficiency of the medicine in the perianal mucosa, can quickly stop bleeding, reduce swelling and relieve pain, has a good repairing effect on anal fissure and damaged mucosa, is comfortable and mild during use, has no obvious stinging or dryness, and has high patient compliance. The preparation is in a liquid form, is refreshing and not greasy, is convenient to use, does not contaminate clothes, is suitable for various indications such as internal hemorrhoids, external hemorrhoids, mixed hemorrhoids, anal fissure and perianal itching, swelling and pain, has definite clinical curative effect, is safe and reliable, and has wide popularization and application value.

A computing system includes a medical application for patient follow-up and education after a healthcare visit. The computing system includes a database with educational materials relating to diagnosis, medications, procedures, etc. A computing system obtains a selection from a healthcare provider, using a provider application or web portal, of the educational materials relating to a patient diagnosis or treatment plan. The computing system provides access to the selected educational materials to the patient using a patient application or web portal. The computing system generates a comprehension test relating to the educational materials and a symptom questionnaire relating to the patient diagnosis or treatment plan. The computing device may also generate a compliance questionnaire relating to patient compliance with the treatment plan. The computing device receives a patient response to the comprehension test, the symptom questionnaire and the compliance questionnaire and provides the patient response to the healthcare provider.

This invention discloses the application of low-concentration topical anesthetics in ophthalmic surgery, relating to the field of low-concentration topical anesthetic application technology, including the following specific application process: confirming the patient's basic surgical condition before administration; selecting anesthetic drugs and optimizing the administration concentration; performing administration according to the specific situation; real-time dynamic monitoring and adjustment of the administration dosage; gradually reducing the drug and transitioning to withdrawal. This invention improves drug safety and patient compliance while ensuring analgesic effects by optimizing anesthetic drug concentration and administration method. Furthermore, by using topical anesthetics at concentrations lower than conventional anesthetics for local administration after ophthalmic surgery, it can effectively relieve postoperative pain, discomfort, and foreign body sensation while significantly reducing toxic effects on corneal epithelial cells, reducing delayed corneal healing, dry eye, and corneal damage. It is effectively applicable to analgesia management after pterygium excision, refractive surgery, and other common ophthalmic surgeries, and has good clinical application value.

This invention relates to an intelligent rehabilitation device and method based on machine vision and thermotherapy technology, belonging to the field of rehabilitation medicine and medical equipment technology. It includes: a multi-angle machine vision monitoring module; an intelligent positioning and temperature control module for the thermotherapy head, including a displacement adjustment mechanism, a thermotherapy head, and a temperature control system; an auxiliary flexion-extension mechanism and linkage control module, including a knee assistive support, a strap, and a drive assembly; and a real-time feedback and remote monitoring module. The multi-angle machine vision monitoring module, the intelligent positioning and temperature control module for the thermotherapy head, and the auxiliary flexion-extension mechanism and linkage control module achieve data fusion and closed-loop linkage control through a main control chip. This invention facilitates real-time and accurate monitoring of rehabilitation movements, intelligent positioning and dynamic temperature control of the thermotherapy head, quantitative evaluation of rehabilitation effects, and closed-loop optimization of training parameters, thereby improving the accuracy, safety, and patient compliance of lower limb joint rehabilitation treatment.

This invention relates to a composition with antitussive effects. By weight, the composition contains 5-25 parts of green plum, 1-20 parts of dried plum, 1-20 parts of monk fruit, 1-20 parts of platycodon root, and 1-20 parts of peppermint. The antitussive composition of this invention scientifically selects and proportions its components, which can reduce the continuous damage to the respiratory system caused by the harsh environment of high altitudes, quickly relieve coughs and dry, itchy throats, etc., shorten the course of the disease, and prevent prolongation and recurrence by prolonging the incubation period of coughs and reducing the frequency and severity of coughs. It also has the advantages of high safety, a sweet and refreshing taste, easy portability, and good patient compliance. It is particularly suitable for preventing and treating severe dry coughs, persistent coughs, and paroxysmal coughs caused by the cold, dryness, and low oxygen levels of high altitudes, maintaining the health and work capacity of personnel working at high altitudes.

It provides a simple and self-contained medication management system that ensures medication is taken as prescribed and prevents missed doses by utilizing built-in reminders and medication verification functions, without relying on external servers or devices. The present invention provides a medication management system having the following configuration: a pocket (4) arranged in 4 rows and 7 columns on the surface of a main body (1), an LED (3) for notifying the scheduled medication, a liquid crystal display (LCD) (6), a confirmation button (5) for confirming medication, a buzzer (2) for voice notification, an SD card reader (7) for storing data, and an RTC module (12) for time management. In addition, a control and communication module is built-in, enabling the management of medication schedules and the transmission of notifications via the Internet. By doing so, a simple and practical system that supports patient compliance with medication is realized.

The present application relates to the field of artificial intelligence medical technology, and discloses a method and system for tracking Helicobacter pylori treatment compliance and follow-up based on artificial intelligence, comprising obtaining multi-dimensional source data of a Helicobacter pylori infected patient throughout the treatment cycle; preprocessing the multi-dimensional source data to obtain a standardized feature data set; performing compliance evaluation on the standardized feature data set based on a machine learning model to obtain a patient compliance classification result; performing risk prediction on the standardized feature data set and the compliance classification result based on a logistic regression model to obtain a multi-dimensional risk quantification score result; using natural language processing technology to analyze the sign feedback text reported by the patient to obtain a structured adverse reaction analysis result; and generating and executing a personalized intervention plan according to the patient's compliance classification result, risk quantification score result and adverse reaction analysis result.

This invention relates to compounds of Formula I or salts thereof. The invention also provides the application of Formula I in the preparation of medicaments for treating JAK-related autoimmune diseases, inflammatory diseases, or cancers, which exhibit significant stability, maintain effective blood concentrations for a certain period, thereby prolonging the drug administration cycle, improving patient compliance, and reducing side effects caused by rapid drug release.

The present invention relates to a controlled release pharmaceutical composition comprising a decongestant, an acrylate copolymer, a cellulose derivative and a crosslinked acrylic acid polymer. The present invention provides an oral dosage form exhibiting a reproducible profile characterized by a controlled release of the decongestant over a period in excess of twelve hours and preferably at least 16 hours after oral administration. The invention further contemplates medical uses thereof. The release profile of the delivery system of the invention is highly reproducible and can be administered once daily, thus improving patient compliance.

The application belongs to the technical field of medicine, and particularly relates to a kind of opicapone oral disintegrating tablets and a preparation method thereof.The active component of the opicapone oral disintegrating tablet is opicapone, and the components are as follows according to weight percentage: opicapone 15-25%; filler 60-70%; glidant 1-4%; lubricant 1-4%; first disintegrating agent 2-6%; and second disintegrating agent 2-6%, wherein the first disintegrating agent and the second disintegrating agent are different, and preferably, the weight content of the opicapone is 15-20%.The opicapone oral disintegrating tablet of the application is suitable for the adjuvant therapy of levodopa / carbidopa, has a fast disintegration rate, stable product quality, does not need to be taken with water, and has strong patient compliance; in addition, the preparation process of the opicapone oral disintegrating tablet of the application is simple, has low cost, and is suitable for mass production.

The present disclosure provides formulations, methods and implantable devices that improve patient compliance by releasing a desired therapeutic agent such as semaglutide for a long time period, such as 1 year or more. The semaglutide concentration (w / w) is more than 1%, such as about 1.1% w / w to about 35% w / w.

This invention discloses a cross-linked nanoprodrug, a nano-self-assembled hydrogel precursor tablet prepared therefrom, and its applications. The nano-self-assembled hydrogel precursor tablet of this invention is prepared by direct compression of the cross-linked nanoprodrug or by compression of a cross-linked nanoprodrug mixed with a drug-loaded orthoester compound. It exhibits high nanodrug content, enhanced nanoparticle release, and high storage and transport stability, as well as good patient compliance. This nano-self-assembled hydrogel precursor tablet responds to the pH gradient environment of the gastrointestinal tract. In acidic gastric juice, through protonation of functional groups, it forms a three-dimensional network structure of nano-self-assembled hydrogel mediated by hydrogen bonds. Subsequently, it stably passes through the small intestine into the colon. In the alkaline colonic environment, its functional groups deprotonate, hydrogen bonds break, and the drug is efficiently released under the electrostatic repulsion between nanoparticles and the synergistic repulsion of the orthoester compound. While preferentially adhering to colonic lesions through electrostatic interactions, it significantly improves the targeted and synergistic therapeutic effect on CRC.

This invention discloses a circular RNA agent targeting PCSK9 and its applications, relating to the field of biomedical technology. The circular RNA agent is a single-stranded closed-circular oligonucleotide containing an antisense sequence complementary to the transcription of the PCSK9 gene. It lacks free 5' and 3' ends, and does not contain overhangs, hairpin structures, or double-stranded regions. The molecules are linked by 3'-5' phosphodiester bonds. This circular RNA agent can be modified with GalNAc or prepared into pharmaceutical compositions for the treatment of diseases or conditions related to abnormal PCSK9 gene expression or activity. The circular RNA agent provided by this invention exhibits high stability, a long half-life, low immunogenicity, low modification toxicity, and high target gene inhibitory activity. It can significantly prolong the dosing interval, improve patient compliance, and provide a safer, longer-acting drug option for lipid-lowering therapy.

This invention relates to a layered acupuncture treatment system and method based on the Five Elements Theory of Traditional Chinese Medicine (TCM), belonging to the field of TCM acupuncture technology and medical devices. The system includes the Five Elements Differentiation Rules, a specialized needle kit, and quantitative operating specifications, establishing a three-in-one technical specification of "Five Elements Anatomical Layers - Needle Mechanical Parameters - Quantitative Operating Standards." Multi-headed fire needles, three-edged fire needles, blunt-tipped round needles, flat-tipped blade needles, and pointed large needles are used to perform differentiated operations corresponding to the five layers of skin, vessels, muscles, tendons, and bones, respectively. Through progressive adjustment of "Five Needles Treating Form, Using Form to Control Qi, Using Qi to Regulate Spirit" (Five Needles Treating Form, Loosening Structure, Promoting Qi and Blood Circulation, and Eliminating Pain), precise matching of needles to the lesion site is achieved, significantly reducing the frequency of treatment while effectively eliminating pain, improving patient compliance, and providing a systematic treatment plan for painful diseases.

This invention relates to the field of biomedical technology and provides the application of taquimod in the preparation of drugs for regulating lymphatic inflammatory responses. Through bioinformatics analysis and cell experiments, this invention demonstrates that taquimod can specifically inhibit the abnormally activated S100A9 / RAGE signaling pathway in lymphatic inflammation, significantly reduce the expression of inflammatory factors, and effectively restore the proliferation, migration, and tube formation function of lymphatic endothelial cells. This provides a novel drug treatment approach based on molecular mechanisms for treating diseases related to lymphatic inflammatory responses such as lymphedema. Furthermore, taquimod, as an oral formulation with proven safety in clinical trials, exhibits good patient compliance and is suitable for long-term use. Compared to existing symptomatic treatments, it holds promise for fundamentally interrupting the vicious cycle of inflammation that drives disease progression, and thus has significant clinical application potential.

This application relates to the technical field of neurosurgery, and in particular to a wearable limb movement care device for neurosurgery. It includes an upper arm storage plate, a forearm storage plate on one side of the upper arm storage plate, and a connecting pad installed on the inner wall of the forearm storage plate. Grooves are formed on the adjacent sides of both the upper arm and forearm storage plates, and connecting rods are installed inside both grooves. A hinge plate is rotatably connected to the outer surface of the right-side connecting rod, and a cylinder is fixedly connected to the outer surface of the hinge plate. This application, through the coordination of the upper arm storage plate, forearm storage plate, and movement care components, allows for proper placement of the arm by the forearm storage plate, facilitating subsequent rehabilitation exercises. The movement of the movement care components enables the patient to exercise their arm, eliminating the need for manual assistance from a therapist, improving treatment efficiency, and avoiding problems such as poor patient compliance and long treatment times.

The present application relates to a kind of hemodialysis patient rehabilitation exercise auxiliary decision system and method, the system includes: data acquisition layer, intelligent analysis and decision-making layer, interactive execution layer and feedback optimization closed loop, data interconnection is realized between the data acquisition layer, intelligent analysis and decision-making layer, interactive execution layer and feedback optimization closed loop.By utilizing artificial intelligence technology, the multidimensional static and dynamic data of patient are fused, accurate and completely personalized rehabilitation exercise prescription is generated, rehabilitation effect and efficiency are improved, real-time risk monitoring and early warning model is established, exercise suggestion is adjusted or terminated according to patient physiological feedback before exercise and during exercise, patient safety is ensured, in addition, the present application constructs "evaluation-decision-execution-feedback-reoptimization" digital closed loop, improves the scientificity, safety and patient compliance of exercise rehabilitation, provides an efficient, accurate and intelligent auxiliary tool for hemodialysis room nurse.

This invention relates to the field of traditional Chinese medicine preparations, and discloses a Tongli capsule and its preparation process, comprising the following raw materials: Eupolyphaga sinensis, processed Arisaema heterophyllum, vinegar-processed frankincense, vinegar-processed myrrh, dragon bone, Angelica dahurica, Lysimachia christinae, safflower, Notopterygium incisum, Angelica sinensis, Saposhnikovia divaricata, Cimicifuga foetida, Ligusticum chuanxiong, and Acorus tatarinowii; wherein, the raw materials are dried, pulverized, mixed, and then filled into capsule shells to form capsules. This Tongli capsule, using a total of fourteen traditional Chinese medicines as raw materials, follows the treatment principles of traditional Chinese medicine of dispelling wind and dampness, relaxing muscles and tendons, and promoting blood circulation and removing blood stasis. It has significant efficacy for late-stage fractures and joint dislocations, joint pain, synovitis, and other diseases caused by wind-cold-dampness obstructing the meridians. Furthermore, the capsule dosage form, with its uniform fine powder contents, makes it convenient to take, provides accurate dosage, has high bioavailability, and improves patient compliance. Compared to decoctions, capsules do not require decocting, making them easier to carry and store; compared to pills and powders, capsules can mask unpleasant odors of the medicine, and disintegrate rapidly, resulting in faster onset of action.

The present invention provides an injectable depot composition comprising linagliptin and low-dose liraglutide. The combination therapy of linagliptin and low-dose liraglutide provides a synergistic effect in the treatment of obesity compared to the administration of each drug alone. In addition, the administration dose of liraglutide can be reduced compared to the administration of liraglutide alone, and thus the direct cause of side effects related to the gastrointestinal system and the cardiovascular system of liraglutide can be reduced. Furthermore, by the combination of linagliptin, it has the advantage of additionally providing an improvement effect on metabolic diseases and cardiovascular diseases related to blood sugar, blood lipids, blood pressure, fatty liver, etc. In addition, compared to the conventional liraglutide dosage form of once-daily subcutaneous injection, the depot composition of linagliptin and liraglutide of the present invention can significantly improve patient convenience and patient compliance by unifying the administration route and improving the administration cycle.

A transdermal sustained-release patch for buspirone hydrochloride comprises a polyester film carrier as the backing layer, a pressure-sensitive adhesive reservoir layer prepared on the surface of the backing layer, and finally covered with a polyethylene protective film to obtain the sustained-release patch. The pressure-sensitive adhesive reservoir layer consists of a drug solution layer and an adhesive layer matrix. The drug solution layer is composed of buspirone hydrochloride, triethylamine, and glycerin, while the adhesive layer matrix is ​​composed of polyacrylate, triethylamine, a penetration enhancer, and glycerin. This invention's transdermal sustained-release patch for buspirone hydrochloride achieves a transdermal bioavailability of over 60% within 24 hours. A dose of 1.5 mg / patch achieves the equivalent effect of 10 mg orally, reducing the dosing frequency from 2-3 times daily to once daily, significantly improving patient compliance. The patch's pH value is controlled at 7.2-7.5, resulting in low skin irritation (HRIPT score ≤1.0). The process is simple, requiring no added sustained-release materials, only standard transdermal patch excipients, making production straightforward.

The present application belongs to the technical field of biological medicine, and particularly relates to a composition for promoting synthesis of an OAHFA derivative family, a microneedle patch and application thereof in preventing and treating dry eye syndrome. The present application first selects an OAHFA derivative as a dry eye treatment target and relies on activation of a PPARγ signal pathway to exert drug efficacy. The composition is compounded from 0.2% to 0.5% PPARγ agonists, 2.0% to 4.0% super-long chain fatty acids and 0.3% to 0.8% ceramides, three effective components. The super-long chain fatty acids supply synthesis substrates, and the ceramides stabilize the interface. The three components synergistically improve the curative effect. The composition described in the present application adopts soluble microneedles for local administration, and the drug release rate is not less than 70% in 30 min. The effect is rapid and the puncture is painless, and the patient compliance is excellent. Local administration eliminates systemic exposure of the drug, and the drug safety is high, and there is no serious adverse reaction.

The present invention relates to the technical field of pharmaceutics, and in particular, to a safe and stable nimodipine formulation for injection and a method for preparing same. The present invention provides a lyophilized nimodipine-cyclodextrin powder for injection, comprising sulfobutylether-β-cyclodextrin, which can significantly improve the solubility, safety, and dilution stability of nimodipine, and increase patient compliance and the convenience of clinical use. Compared with a commercially available nimodipine injection NIMOTOP, the present invention has significant advantages in safety and dilution stability.

Provided are an oral dissolving film composition of rivaroxaban, a method for preparing same, and use thereof. The oral dissolving film composition comprises one or more of rivaroxaban and a pharmaceutically acceptable salt, hydrate, and solvate thereof as an active ingredient, and a film-forming material. Also, the present invention features a simple process, no sedimentation during the preparation of film solutions, qualified content uniformity, high drug loading capacity, and improved patient compliance, and is particularly suitable for patients with dysphagia.

The present application relates to a kind of vertebral body fracture postoperative secondary fracture risk prediction model, construction method and prediction system, including the multidimensional data of collection research object;The multidimensional data of the research object meeting the requirements is standardized pre-processing;Fractured vertebral body positioning sub-network is constructed, and the output ROI of injured vertebra is input into image parameter measurement sub-network, and the output result is converted to obtain standardized image parameter set;Standardized image parameter set and clinical data are merged, and independent predictive factor is screened;Based on independent predictive factor, the risk prediction model of vertebral body fracture postoperative secondary fracture based on nomogram is constructed.The present application realizes the automatic, standardized extraction of multimodal image parameters by cascading CNN network, integrates multi-center patient baseline data, surgery-related data and postoperative nursing data, and can be used for accurately predicting the risk of secondary OVCF within 2 years after operation by feature screening and model construction;Solve the problems of poor generalization, strong subjectivity and insufficient patient compliance in the prior art.

This invention discloses a traditional Chinese medicine composition for the prevention and treatment of throat and oral diseases, and its preparation method. The composition comprises poultry egg yolk oil, honey, platycodon root, dandelion, licorice, monk fruit, menthol, and maltose in specific weight proportions. Its preparation includes steps such as frying poultry egg yolk oil, preparing water extracts of platycodon root and dandelion, and mixing with maltose to form a final product. The composition of this invention uses only food-grade medicinal materials, ensuring safety and reliability. When formulated into topical dosage forms such as lozenges, it provides long-lasting effects on the affected area, offering multiple benefits including analgesia, anti-inflammation, mucosal repair, and cough suppression. It effectively solves the problems of significant side effects and limited duration of local application in existing oral medications. This product has a pleasant taste and high patient compliance, making it suitable for the prevention and treatment of throat and oral diseases such as pharyngitis, tonsillitis, oral ulcers, gingivitis, and sore throat.