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34 results about "Inhibitory neurotransmitter" patented technology

Non-invasive vagal nerve stimulation to treat disorders

Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and / or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and / or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
Owner:ELECTROCORE

Systems and methods for vagal nerve stimulation

Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm that includes single doses of 30 seconds to 5 minutes of continuous stimulation. The treatment paradigm further comprises one or more daily treatment sessions that each include one or more doses for prophylactic or acute treatment of the patient's condition. Vagus nerve stimulation is used to modulate the release of inhibitory neurotransmitters in the brain, such as GABA, norepinephrine, and / or serotonin.
Owner:ELECTROCORE

Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders

Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The methods provide damaged interstitial cells of Cajal (ICC) with trophic factors via vagal afferent nerve fibers, thereby reversing ICC damage, and as a consequence improving gastric motility. The methods also increase levels of inhibitory neurotransmitters in the brain so as to decrease neural activity within the area postrema, or they deactivate a resting state neural network containing parts of the anterior insula and anterior cingulate cortex, which will thereby reduce abnormal interoception and visceral hypersensitivity.
Owner:ELECTROCORE

Non-invasive vagal nerve stimulation to treat disorders

Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and / or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and / or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
Owner:ELECTROCORE

Nerve stimulation methods for averting imminent onset or episode of a disease

Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and / or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and / or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
Owner:ELECTROCORE

Non-invasive vagal nerve stimulation to treat disorders

Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and / or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and / or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
Owner:ELECTROCORE

Non-invasive vagal nerve stimulation to treat disorders

ActiveUS20150032178A1Generate lotReduced level of neurotransmitter levelElectrotherapyMagnetotherapy using coils/electromagnetsDiseaseNon invasive
Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The technology involves the use of an energy source comprising magnetic and / or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and / or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
Owner:ELECTROCORE

Lily bulb and rhizoma rehmanniae soup standard decoction with anti-depression function and preparing method and application thereof

The invention belongs to the field of traditional Chinese medicine, and particularly relates to a preparing method of a lily bulb and rhizoma rehmanniae soup standard decoction with an anti-depressionfunction. Firstly, records about dosages of a classical prescription lily bulb and rhizoma rehmanniae soup, production places of geo-authentic crude drugs and preparing methods of the classical prescription are looked up in the literature of past dynasties, and then the classical prescription lily bulb and rhizoma rehmanniae soup standard decoction is prepared; after the lily bulb and rhizoma rehmanniae soup is intervened in, the content of monoamine neurotransmitters 5-HT, NE and DA is increased, the content of inhibitory neurotransmitters is lowered, and the content of excitatory neurotransmitters is increased; finally, a high performance liquid chromatograph is utilized for analyzing the active ingredients for the drug effect of the decoction, a modern scientific basis is provided forthe depression treatment function mechanism and drug-using formula of the classical prescription lily bulb and rhizoma rehmanniae soup, and the decoction has high theoretical significance and clinicalvalue.
Owner:SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE

Traditional Chinese medicine preparation for treating epilepsia and preparation method thereof

A traditional Chinese medicine preparation for treating epilepsia comprises poria cocos, rhizoma cyperi, curcuma zedoary, pericarpium citri reticulatae viride, platycladi seed, rhizoma corydalis, rhizoma acori graminei, gastrodia elata, periostracum cicada, polygala tenuifolia, glossy privet fruit, cortex albiziae, tuber fleeceflower stem, codonopsis pilosula, salviae miltiorrhizae, radix paeoniae alba, spina date seed, raw oyster shell, uncaria rhynchophylla, frankincense, scorpion, leech, silkworm larva, ground beeltle and arisaema cum bile. The traditional Chinese medicine preparation integrates brain function improvement, traditional Chinese medicine recuperation and epilepsia resistance, treats both principal and secondary aspects of a disease through normal flora growth fostering, organism immune enhancement, inhibitory neurotransmitter gamma amino butyric acid (GABA) content improvement, controls symptoms of epilepsia, enables damaged cranial nerves to be repaired and regenerated, and utilizes interaction of a medicine to offset or withstand side effects of western medicines. The epilepsia is not prone to reappear.
Owner:重庆桐雨石科技有限公司

Composition and beverage for improving sleep and preparation method

The invention provides a composition and beverage for improving sleep and a preparation method, relates to a health care product and a preparation method, and aims to solve the problem of low sleep quality of people. The composition for improving sleep is prepared from spina date seeds, poria cocos, ginseng, licorice roots and gamma-aminobutyric acid. The composition can promote brain activation,strengthen the brain, soothe the nerves, resist epilepsy, promote sleep, beautify the features, moisten the skin, delay aging, supplement human body inhibitory neurotransmitters, promote kidney function improvement and protection, inhibit fatty liver and obesity, activate liver functions, and has good blood pressure reducing, blood nourishing, nerve soothing, heat clearing and restlessness relieving effects.
Owner:黑龙江北草堂中药材有限责任公司

Systems and methods for vagal nerve stimulation

Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm that includes single doses of 30 seconds to 5 minutes of continuous stimulation. The treatment paradigm further comprises one or more daily treatment sessions that each include one or more doses for prophylactic or acute treatment of the patient's condition. Vagus nerve stimulation is used to modulate the release of inhibitory neurotransmitters in the brain, such as GABA, norepinephrine, and / or serotonin.
Owner:ELECTROCORE

Method for separating precursor cells producing gabaergic neuron alone

To treat epilepsy or schizophrenia by transplanting precursor cells of GABAergic neurons into a region where GABAergic neurons are lost or decreased in the brain of a patient suffering from the disease, it is intended to provide a method for separating a precursor cell of GABAergic neuron in an adult or a fetal nerve tissue or a precursor cell of GABAergic neuron derived from an embryo stem cell. The invention of this application comprises the step of preparing a cell population containing a precursor cell of GABAergic neuron, the step of introducing a DNA, in which a reporter gene emitting fluorescence detectable even in vivo is attached to the downstream of a promoter of GAD67 gene or GAD65 gene that is gene of an inhibitory neurotransmitter GABA synthase, into dispersed cells, the step of isolating a GABAergic neuron and a precursor cell of GABAergic neuron based on the presence / absence of the fluorescence from the reporter protein, and the step of isolating the precursor cell of GABAergic neuron based on the possession of proliferative capability.
Owner:SHIRANKAI KYOTO UNIV FACULTY OF MEDICINE ALUMNI ASSOC

Composition for protecting nervous system, improving memory and preventing senile dementia

The invention discloses a composition for protecting nervous system, improving memory and preventing senile dementia. The composition comprises the following components in parts by weight: 29-38 parts of xylitol, 16-22 parts of DHA algae oil, 3-5 parts of phosphatidylserine, 2-8 parts of gamma aminobutyric acid, 9-13 parts of tangerine pericarp, 8-11 parts of corn flour, and 20-26 parts of Kiwi powder. The composition has the advantages that the DHA algae oil contained in the composition can promote brain growth, and prevents brain function degradation due to increase of age, phosphatidylserine has the functions for alleviating brain balance and adverse emotion, the gamma aminobutyric acid has the functions for promoting brain activation, invigorating brain and developing intelligence, resisting epilepsy, promoting sleep, delaying brain aging function, and supplementing human body inhibitory neurotransmitter, so that the composition has the effects for protecting nervous system, improving memory and preventing senile dementia.
Owner:ZHONGXIANG YIYUAN BIOLOGICAL SCI & TECHCO

Nutritional health dried sweet potatoes and preparation method thereof

The invention provides nutritional health dried sweet potatoes and a preparation method thereof, belonging to the technical field of food processing. The dried sweet potatoes comprise the following raw materials: sweet potatoes, walnuts, cape jasmine, lucid ganoderma, astragalus membranaceus and red ginseng. The dried sweet potatoes have medicinal functions of promoting brain activation, benefiting the brain, developing intelligence, promoting sleep, beautifying and moistening skin, delaying brain aging function, replenishing inhibitory neurotransmitter of a human body, well reducing blood pressure, promoting improvement and protection of kidney function, inhibiting fatty liver, activating liver function, improving the immunity of the human body, resisting radiation, inhibiting tumors and the like; meanwhile, by adopting a unique preparation process, the original nutrition and specific flavor of the sweet potatoes can be kept, the energy resources can be saved, the waste can be reduced, the processing time can be shortened, and the efficiency can be improved.
Owner:TONGREN CITY WANSHAN DISTRICT RUIFENG GREEN FOOD

Formula of milk-derived polypeptide composite protein beverage for reducing pressure and promoting sleep

The invention relates to a formula of a milk-derived polypeptide composite protein beverage for reducing pressure and promoting sleep, and solves problems of high pressure, anxiety and insomnia of numerous people in the prior art. The formula comprises the following components in percentage by weight: 30%-40% of milk-derived polypeptide, 35%-45% of gamma-aminobutyric acid, 15%-25% of asparagus powder and 3%-7% of casein hydrolysate. According the formula, the intestines, stomach and sleep of a user are conditioned through the milk-derived polypeptide, the gamma-aminobutyric acid not only has arelieving effect on hypertension, but also inhibits neurotransmitter and relieves anxiety, depression and other emotions of people, the asparagus powder is a natural food for improving sleep and relieving pressure, and the casein hydrolysate can provide protein for the human body. The beverage can reduce generation frequency of anxiety, dysphoria and other negative emotions, a drinker is relaxedin mind and body, can well enter natural sleep, the sleep quality is improved, and the beverage has a good application prospect.
Owner:吴宜

Vegetable paper with blood pressure-lowering health-care effect and preparation method thereof

The present invention discloses a vegetable paper with blood pressure-lowering health-care effect and a preparation method thereof. According to the vegetable paper, chrysanthemum nankingense is takenas a main raw material, contains abundant proteins, cellulose and minerals, and has the health-care functions of clearing away heat and toxic materials and lowering blood pressure; sesame pollen, gamma-aminobutyric acid and tea seed oil are supplemented, and are capable of supplementing human body with inhibitory neurotransmitter, enhancing immunity and strengthening the health-care effect of lowering blood pressure; fruit juice not only enriches the nutrient components, but also improves the taste; beta-cyclodextrin is used for pretreatment, and can permeate into vegetable tissues to preventthe later drying, shrinkage and hardening and to improve the appearance quality; a color fixative is used to keep the original flavor of the vegetables to a large extent; and the microwave vacuum drying can prevent corn starch from producing strong starch taste caused by high temperature, so that the chrysanthemum nankingense vegetable paper with a bluish green color, a crisp mouth feel and faintfragrance can also be obtained.
Owner:FOSHAN SHIRUI LEADING MATERIAL RES INST GENERAL PARTNERSHIP

Anxiolytic drug and preparation method thereof

The invention provides an anxiolytic drug and a preparation method thereof, wherein the anxiolytic drug is prepared by the following raw materials in parts by weight: 5-25 parts of rhodiola rosea, 5-15 parts of hypericum perforatum, 5-15 parts of gastrodia elata, and 5-18 parts of rehmanniae vaporata. The anxiolytic drug has the advantages of reasonable formulation, simplicity in preparation and obvious effect. The animal experiment indicates that the anxiolytic drug can obviously enhance the secretion level of inhibitory neurotransmitter in serum, namely reanal GABA, obviously enhances the anxiolytic action capacity of mice, and has no side effects to affect learning and memory abilities after being taken for a long term.
Owner:NAVY MEDICINE RES INST OF PLA

GABA and electrophysiology micro-nano synchronous sensing detection chip and preparation method thereof

The invention provides a GABA and electrophysiological micro-nano synchronous sensing detection chip and a preparation method thereof. The micro-nano synchronous sensing detection chip comprises a substrate layer, a conductive layer and an insulating layer, wherein the substrate layer is made of a flexible material and covers a bottom support; the conductive layer is formed on the substrate layerand used for synchronously detecting changes of inhibitory neurotransmitter GABA and neuroelectric signals in multiple different sub-regions of a rat hippocampus structure; the conductive layer comprises detection site groups which are distributed at positions matching with the size of the rat hippocampus structure and distributed in different sub-regions of the rat hippocampus structure in a radiation manner along the diagonal direction of a detection region; and the insulating layer is made of a flexible material and is formed on the substrate layer except the area where the detection site groups are located. According to the invention, the inhibitory neurotransmitter and the electrical signals can be synchronously detected, and a microprocessing technology, a nanometer material and a biologically sensitive film technology are combined, so the neural information network and the pathogenesis of neurodegenerative diseases can be easily found and understood.
Owner:INST OF ELECTRONICS CHINESE ACAD OF SCI

GABA and electrophysiological micro-nano synchronous sensing detection chip and preparation method thereof

The disclosure provides a GABA and electrophysiological micro-nano synchronous sensing detection chip and a preparation method thereof, wherein the micro-nano synchronous sensing detection chip includes: a base layer, a conductive layer and an insulating layer; the base layer is a flexible material, and the base layer Overlaid on the bottom support; the conductive layer is formed on the base layer, and is used to synchronously detect the changes of the inhibitory neurotransmitter GABA and nerve electrical signals in many different sub-regions of the hippocampal structure of the rat; the conductive layer includes: detection sites group, the distribution position matches the size of the rat hippocampus, and the detection site group radiates along the diagonal direction of the detection area and is distributed in different sub-regions of the rat hippocampus; the insulating layer is a flexible material, and the insulating layer is formed on the On the basal layer outside the region where the group of detection sites is located. The disclosure can simultaneously detect inhibitory neurotransmitters and electrical signals, combined with micro-processing technology, nano-materials and bio-sensitive thin film technology, to help discover and understand neural information networks and the pathogenic mechanism of biblical degenerative diseases.
Owner:INST OF ELECTRONICS CHINESE ACAD OF SCI

Beverage composition for relieving pressure, relaxing mood and improving sleep of young people and preparation method thereof

The invention relates to a beverage composition for relieving pressure, relaxing mood and improving sleep of young people and a preparation method of the beverage composition. The beverage composition consists of the following components: gamma-aminobutyric acid, tea theanine, spina date seed powder, xylooligosaccharide, sour cherry concentrated powder, melissa powder, a German chamomile flower extract, passion flower powder, elderberry fruit juice powder and the like. The level of inhibitory neurotransmitter gamma-aminobutyric acid is up-regulated and the level of excitatory neurotransmitter glutamic acid is down-regulated through food with homology of medicine and food, so that the gamma-aminobutyric acid and the glutamic acid are balanced, and the effects of relieving the pressure, anxiety and depression of young people, antagonizing the excitation of caffeine and finally improving sleep are achieved. Zebra fish and human body tests prove that the traditional Chinese medicine is remarkable in effect and worthy of being popularized among young people with insomnia.
Owner:WUXI JIANTE PHARM CO LTD +1

Sleep-aiding asparagus chewable tablet and preparation method thereof

The present invention belongs to a human immunity enhancing asparagus chewable tablet, and relates to the technical field of food processing, the human immunity enhancing asparagus chewable tablet comprises 10-60 parts of 1, isomaltitol, 10-60 parts of asparagus powder, 5-12 parts of apple powder, 0.5-5 parts of gamma-aminobutyric acid, 0.5-5 parts of tea leaf theanine, 0.5-2 parts of magnesium stearate, and 0.5-4 parts of sucralose; the mass percentage content of asparagus saponin in the asparagus powder is greater than or equal to 12.5%. The preparation method comprises the following steps: preparing the asparagus powder, mixing and stirring, granulating and tabletting. The asparagus saponin in the asparagus powder is suitable for people with insufficient sleep or to-be-improved sleep quality caused by malnutrition or biological rhythm disorder and other reasons. Gamma-aminobutyric acid is a very important inhibitory neurotransmitter, mainly participates in physiological activities of brains and has the effects of soothing nerves, hypnosis and the like. A certain effect on maintaining brain health is achieved. The tea leaf theanine can obviously promote the release of dopamine in the brain center and improve the physiological activity of dopamine in the brain.
Owner:四川工大西南食品研究有限责任公司

Anxiolytic drug and preparation method thereof

The invention provides an anxiolytic drug and a preparation method thereof, wherein the anxiolytic drug is prepared by the following raw materials in parts by weight: 5-25 parts of rhodiola rosea, 5-15 parts of hypericum perforatum, 5-15 parts of gastrodia elata, and 5-18 parts of rehmanniae vaporata. The anxiolytic drug has the advantages of reasonable formulation, simplicity in preparation and obvious effect. The animal experiment indicates that the anxiolytic drug can obviously enhance the secretion level of inhibitory neurotransmitter in serum, namely reanal GABA, obviously enhances the anxiolytic action capacity of mice, and has no side effects to affect learning and memory abilities after being taken for a long term.
Owner:NAVY MEDICINE RES INST OF PLA

Hexapeptide with sleep improving activity and application thereof

The invention discloses a hexapeptide with sleep improving activity and application of the hexapeptide. The primary structure amino acid sequence of the hexapeptide is Tyr-Pro-Val-Glu-Pro-Phe, and the molecular weight of the hexapeptide is 750.85 Da. The hexapeptide provided by the invention can be chemically synthesized, and also can be directionally prepared from casein enzymolysis products. The hexapeptide provided by the invention has obvious sleep improvement activity, which is mainly reflected in that the sleep rate of mice can be obviously increased and the time of pentobarbital sodium induced sleep of mice can be prolonged. Meanwhile, the ratio of the inhibitory neurotransmitter gamma-aminobutyric acid GABA to the excitatory neurotransmitter glutamic acid Glu can be remarkably increased, and the compound has a good effect of enhancing the sleep of the mice and can be directly used in food or medicine for preventing and treating insomnia or sleep disorder diseases.
Owner:SOUTH CHINA UNIV OF TECH +1

Traditional Chinese medicine preparation for treating epilepsia and preparation method thereof

A traditional Chinese medicine preparation for treating epilepsia comprises poria cocos, rhizoma cyperi, curcuma zedoary, pericarpium citri reticulatae viride, platycladi seed, rhizoma corydalis, rhizoma acori graminei, gastrodia elata, periostracum cicada, polygala tenuifolia, glossy privet fruit, cortex albiziae, tuber fleeceflower stem, codonopsis pilosula, salviae miltiorrhizae, radix paeoniae alba, spina date seed, raw oyster shell, uncaria rhynchophylla, frankincense, scorpion, leech, silkworm larva, ground beeltle and arisaema cum bile. The traditional Chinese medicine preparation integrates brain function improvement, traditional Chinese medicine recuperation and epilepsia resistance, treats both principal and secondary aspects of a disease through normal flora growth fostering, organism immune enhancement, inhibitory neurotransmitter gamma amino butyric acid (GABA) content improvement, controls symptoms of epilepsia, enables damaged cranial nerves to be repaired and regenerated, and utilizes interaction of a medicine to offset or withstand side effects of western medicines. The epilepsia is not prone to reappear.
Owner:重庆桐雨石科技有限公司
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