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Lily bulb and rhizoma rehmanniae soup standard decoction with anti-depression function and preparing method and application thereof

A Baihe Dihuang Decoction, anti-depressant technology, applied to medical preparations containing active ingredients, drug combinations, medical formulas, etc., can solve the problems of slow improvement of clinical symptoms, easy recurrence of side effects, complex etiology of depression, etc.

Inactive Publication Date: 2019-11-15
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The etiology of depression is complex, and there are many hypotheses on its pathogenesis. Various antidepressants developed based on this only benefit some patients, and there are defects such as slow improvement of clinical symptoms, easy relapse, and many side effects, which suggest that the existing depression Mechanisms are insufficient to explain this multietiologically heterogeneous disease

Method used

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  • Lily bulb and rhizoma rehmanniae soup standard decoction with anti-depression function and preparing method and application thereof
  • Lily bulb and rhizoma rehmanniae soup standard decoction with anti-depression function and preparing method and application thereof
  • Lily bulb and rhizoma rehmanniae soup standard decoction with anti-depression function and preparing method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation method of standard decoction comprises the following steps:

[0038] (1) Fresh rehmannia glutinosa from Jiaozuo area, Henan Province was selected, and after several times of juicing, the juice yield of fresh rehmannia glutinosa was about 50%, that is, 400 g of fresh rehmannia glutinosa was squeezed to about 200 ml. Lily bulbs from Shennongjia, Hubei Province were selected as the measured medicinal materials. After measurement, it was found that 7 lily bulbs (washed and soaked for one night) were about 400 g when fresh, and about 175 g when dried.

[0039] (2) About 400 g of fresh lily bulbs from the Shennongjia area of ​​Hubei Province (washed and soaked for one night) were boiled in 400 ml of spring water to obtain 200 ml of lily decoction;

[0040] (3) Add 200 ml of freshly squeezed fresh rehmannia root from Jiaozuo, Henan Province (about 400g of fresh rehmannia root squeezed) and mix and cook to obtain a standard decoction of 300 ml Lily Rehmannia De...

Embodiment 2

[0042] 1. Lily Chromatography Conditions and Preparation of Detection Solution

[0043] The mobile phase was acetonitrile (A)-0.05% phosphoric acid water (B), and the elution gradient (0~6 min, 5%A; 6~15 min, 5%~14%A; 15~25 min, 14%A A; 25-30 min, 14%-21%A; 30-35 min, 21%A; 35-45 min, 21%-36%A; 45-51 min, 36%A; 51-63 min, 36%A %~66.3%A; 63~70min, 66.3%A; 70~83min, 66.3%~100%A; 83~90min, 90%A), flow rate 1.0mL / min, column temperature 30° C, the detection wavelength of ferulic acid component is 330 nm, the detection wavelength of dioscin component is 205 nm, and the injection volume is 20 μL.

[0044] Preparation of reference solution:

[0045] Take an appropriate amount of reference substances of ferulic acid and diosgenin, weigh them accurately, add 80% methanol to make a reference solution with a concentration of 0.0200 mg / mL, shake well, and ultrasonically dissolve them completely for 5 minutes, and filter them with a microporous membrane (0.45 μm oil film) to filter, tak...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and particularly relates to a preparing method of a lily bulb and rhizoma rehmanniae soup standard decoction with an anti-depressionfunction. Firstly, records about dosages of a classical prescription lily bulb and rhizoma rehmanniae soup, production places of geo-authentic crude drugs and preparing methods of the classical prescription are looked up in the literature of past dynasties, and then the classical prescription lily bulb and rhizoma rehmanniae soup standard decoction is prepared; after the lily bulb and rhizoma rehmanniae soup is intervened in, the content of monoamine neurotransmitters 5-HT, NE and DA is increased, the content of inhibitory neurotransmitters is lowered, and the content of excitatory neurotransmitters is increased; finally, a high performance liquid chromatograph is utilized for analyzing the active ingredients for the drug effect of the decoction, a modern scientific basis is provided forthe depression treatment function mechanism and drug-using formula of the classical prescription lily bulb and rhizoma rehmanniae soup, and the decoction has high theoretical significance and clinicalvalue.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a preparation method and application of a standard decoction of Baihe Dihuang Decoction with antidepressant effect. Background technique [0002] Depression is a mental illness with depression, slow thinking, decreased or slow speech and movement as the main clinical symptoms, including postpartum depression, menopausal depression, mental depression and other types, which seriously affect the lives of patients . A joint study by the World Health Organization shows that depression has become the second largest disease burden in China. The etiology of depression is complex, and there are many hypotheses on its pathogenesis. Various antidepressants developed based on this only benefit some patients, and there are defects such as slow improvement of clinical symptoms, easy relapse, and many side effects, which suggest that the existing depression Mechanisms ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8967A61P25/24G01N30/02
CPCA61K36/8967A61K36/804A61P25/24G01N30/02A61K2300/00A61K2236/00G01N30/88G01N30/34
Inventor 马柯王世军王媛赵海军张洪秀马山
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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