272results about "Inanimate material medical ingredients" patented technology

The invention relates to the field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for treating cognitive impairment of Parkinson's disease and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 180-220 parts of vinegar tortoise plastron, 90-110 parts of morinda officinalis, 90-110 parts of angelica sinensis, 90-110 parts of radix curcumae, 55-65 parts of rhizoma acori graminei, 55-65 parts of polygala tenuifolia, 180-220 parts of calcined dragon bone, 180-220 parts of caulis spatholobi and 1-3 parts of borneol. When all the medicines of the traditional Chinese medicine composition are combined, the compatibility of monarch, minister, assistant and guide is performed, so that the traditional Chinese medicine composition has the effects of tonifying kidney, promoting blood circulation, dispersing blood stasis and inducing resuscitation, can relieve cognitive impairments such as space navigation, space exploration, working memory and the like of a Parkinson's disease cognitive impairment model mouse caused by chronic hypoperfusion, and realizes the treatment effect on the Parkinson's disease cognitive impairment; good application prospects are realized.

The present disclosure relates to compositions and methods comprising a yeast cell wall extract and a clay material admixed to a proteinaceous and / or cell wall extract(s) from bacterial or fungal fermentation from amino acid production. In another embodiment, the present compositions comprise a yeast cell wall extract, a clay material, and an algal material admixed to a proteinaceous and / or cell wall extract(s) from bacterial or fungal fermentation from amino acid production. This disclosure also relates to methods of utilizing the same to sequester and / or adsorb mycotoxins internal or external to an animal, thereby reducing and / or preventing the toxic and harmful effects of mycotoxin contamination and / or infection in animals. Specifically, application of the present methods and compositions are found in the dietary administration and / or co-administration of the present compositions to animals in animal feed and / or animal production systems, as well as in therapeutic, prophylactic, and research applications.

The present invention aims to provide a composition having excellent anti-aging properties. [Solution] A composition characterized by containing nicotinamide mononucleotide and at least one selected from the group consisting of pine bark, banaba, and fulvic acid.

The invention discloses a phlebitis treatment gel containing a coptis chinensis-wine-treated rhubarb compound component and a preparation method of the phlebitis treatment gel. The active ingredients of the gel are coptis chinensis, rheum officinale and wine-treated rheum officinale in a mass ratio of (1.5-2.5): (1.5-2.5): 1, preferably 2: 2: 1. Lavender essential oil, tea tree essential oil, folium eucalypti essential oil and vinegar frankincense, radix trichosanthis and other traditional Chinese medicine auxiliary materials are used as auxiliary materials. The preparation method comprises the following steps: extracting twice with ethanol, mixing extracting solutions, adding borneol, menthol and essential oil, and finally gelling with carbomer. The phlebitis gel can be independently used or combined with indometacin to form dual-channel anti-inflammation, and the defects of skin atrophy, toxicity accumulation and the like of traditional phlebitis gel are overcome. The traditional Chinese medicine composition is clinically expanded and applied to first-stage pressure sores (without skin damage), acnes and mosquito bites, red and swollen of the first-stage pressure sores fade away within 3-5 days, red and swollen of the acnes are relieved by more than or equal to 60% when the traditional Chinese medicine composition is combined with oral medicine for 48 hours, the itching relieving effect on the mosquito bites is less than or equal to 30 minutes, and the curative effect on phlebitis is remarkably superior to that of 50% magnesium sulfate (Plt;

The invention discloses traditional Chinese medicine suspension eye drops and a preparation method thereof, and the traditional Chinese medicine suspension eye drops are prepared from the following raw materials in parts by weight: 1-3 parts of a traditional Chinese medicine composition, 4-7 parts of hydroxypropyl-beta-cyclodextrin, 0.5-2 parts of microcrystalline cellulose-sodium carboxymethyl cellulose and auxiliary materials. The traditional Chinese medicine suspension eye drops provided by the invention abandon a traditional eye ointment form, are directly dropped for use, are convenient to use, have good stability and dispersity, and are excellent in use curative effect and medication experience; on the basis of keeping the clinical efficacy of the Marcher eight-treasure ancient prescription, secondary development and research are scientifically carried out, so that the Marcher eight-treasure ancient prescription plays a greater clinical treatment role, and has a wider market development prospect.

The invention relates to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating Parkinson's disease, namely tremor syndrome of traditional Chinese medicine, which comprises the following raw materials by weight: 390-470g of liver calming and wind calming medicine, 140-160g of radix rehmanniae, 280-320g of radix paeoniae alba, 840-960g of first decoction medicine, 390-450g of blood activating and qi regulating and tendon and collateral dredging medicine, and 305-355g of antidote. The traditional Chinese medicine composition has remarkable effects of relaxing tendons and detoxifying, and calming endogenous wind and arresting fibrillation, can play a role in solving the problems of head shaking, limb tremor, muscle stiffness, dyskinesia and the like caused by liver wind internal movement and kidney deficiency and toxic damage of Parkinson's disease, and can nourish liver and kidney, relieve tendon and vessel contracture and relieve pain due to the synergistic effect of various traditional Chinese medicinal materials contained in the traditional Chinese medicine composition. The traditional Chinese medicine composition is especially suitable for Parkinson patients with liver-wind internal movement and kidney deficiency and toxicity loss, and can gradually improve the neurotransmitter level in the brain after being taken. The traditional Chinese medicine composition has an outstanding detoxification effect, can effectively remove accumulation of pathological products such as phlegm and blood stasis in the body of the Parkinson's disease patient, prevents phlegm and blood stasis from generating toxins, and can relieve medicine poison generated by long-term medicine taking of the patient.

The invention discloses an external application ointment for mud moxibustion and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The external application ointment for mud moxibustion is prepared from the following components in parts by weight: 15-30 parts of traditional Chinese medicine extract, 40-60 parts of mineral mud, 5-15 parts of beewax, 2-8 parts of penetration enhancer, 1-5 parts of stabilizer and 1-3 parts of dipotassium glycyrrhizinate, wherein the traditional Chinese medicine extract is prepared by the following steps: weighing sarcandra glabra or kadsura coccinea, giantleaf ardisia rhizome, kadsura coccinea, folium artemisiae argyi and garden balsam stem according to the weight ratio of (6-10): (4-8): (3-7): (1-6): (1-5), crushing, adding water for soaking, decocting, filtering, and concentrating the filtrate into extract with the relative density of 1.1-1.2 at 60 DEG C, thereby obtaining the traditional Chinese medicine extract. The formula of the traditional Chinese medicine extract in the ointment is elaborately developed from clinical proved prescriptions, the formula is simple, and the ointment has remarkable effects of activating blood, dispelling wind, eliminating dampness and relieving pain on symptoms such as pain caused by various reasons.

The invention discloses a dampness-clearing and soothing foot bath bag based on Mongolian medicine traditional Chinese medicine homologous red mud and a preparation process thereof, and relates to the technical field of life cultivation and health preservation products. The process comprises the following steps: selecting Mongolian medicine and traditional Chinese medicine homologous deep red mud which is below two meters underground, naturally drying in the sun, frying at 120-150 DEG C until the red mud is loose and light brown, and carrying out superfine grinding to 200 meshes; respectively preparing medicinal material powder of folium artemisiae argyi, flos carthami and fresh ginger; 80 parts by weight of red mud powder, 10 parts by weight of folium artemisiae argyi powder, 5 parts by weight of safflower powder and 5 parts by weight of ginger powder are fully stirred, mixed and subpackaged. Through the unique sun-drying-stir-frying-superfine grinding pretreatment technology, the problem that red mud is prone to caking is effectively solved, and the dissolution rate of active ingredients is greatly increased; meanwhile, by means of synergistic compatibility of the red mud mineral substances and the traditional Chinese medicinal materials, the obvious damp-clearing and soothing effects are achieved, use is convenient, and foot pollution is avoided.

The invention discloses a composition, a medicine containing the composition, a combined medicine and application. The composition comprises fructus evodiae or other qi promoting components, a blood stasis dispersing component, a middle-jiao warming, cold dispelling and spleen tonifying component, liquorice, a blood generating and activating component, a wind-cold dispersing component and a kidney reinforcing component. The composition disclosed by the invention has a good antiviral effect, and can assist qi and blood generation so as to transform cold-dampness, so that antiviral effect is realized, and meanwhile, the body function is improved.

The application provides a medicinal composition for treating sympathetic cervical spondylosis, which is prepared from the following raw medicinal materials in the following proportions: Gualoupi 5-15 parts, Xiebai 5-15 parts, Fabanxia 8-20 parts, Guizhi 5-15 parts, Fushen 10-30 parts, Shenghuangqi 20-60 parts, Chao Wu Zhu 5-15 parts, Shengbaishu 10-30 parts, Muxiang 5-15 parts, Shigai 8-20 parts, Zhizhi 5-15 parts, Longgu 8-20 parts, and Muli 8-20 parts. The application also provides a preparation method and use of the medicinal composition. The medicinal composition has the effects of benefiting qi and activating yang, promoting qi and dredging collaterals, and eliminating swelling and relieving pain, and the compatibility of the medicinal materials can synergistically enhance the effects, so that the medicinal composition has good effects on sympathetic cervical spondylosis and can effectively reduce the clinical recurrence rate. In addition, the medicinal composition has fewer raw medicinal materials, is convenient to prepare and use, has high clinical compliance of patients, and has a good clinical application prospect.

Amyotrophic lateral sclerosis (ALS) is a life-threatening neurodegenerative disease characterized by the progressive loss of motor neurons. Muse cells are endogenous reparative pluripotent-like stem cells distributed to various tissues. Once intravenously injected, such cells, upon sensing sphingosine-1-phosphate produced by damaged cells, settle selectively on damaged sites, and after homing, can exhibit multiphase effects including natural differentiation into tissue-protecting and tissue-reconstructing cells. In the present invention, with G93A-Tg mice serving as an ALS model, human Muse cells injected intravenously successfully homed into the lumbar cord, mainly at the pia mater and the lower white matter, and expressed glial-like forms and GFAP. Meanwhile, no such homing or differentiation was observed in the case of human mesenchymal stem cells (MSC), and, rather, MSCs were found distributed to the lungs. The Muse group demonstrated significant improvement in the scores of rotarod, hanging wire, and lower extremity muscle strength, recovered the motor neuron number, and significantly reduced denervation and muscle fiber atrophy of lower extremity muscles as compared to the medium group. Furthermore, the Muse cell effect on motor function of TDP-43 Tg mice serving as an ALS model was evaluated. The results shows that, compared to the medium group, the Muse group had a significantly improved hanging wire test score. These results indicate that Muse cells perform homing in a damaged-site-dependent manner, and protect the spinal cord in response to the death of motor neurons, and thus Muse cells are useful for treatment of ALS patients.

The invention discloses a colon-targeted pharmaceutical composition as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The invention aims to solve the technical problems that the existing 5-aminosalicylic acid preparation is low in targeted delivery efficiency and lacks a synergistic interaction mechanism. According to the pharmaceutical composition, 5-aminosalicylic acid is used as a treatment component, and pH response type composite hydrogel constructed by sodium humate and sodium alginate is used as a carrier. The core characteristic of the pH-responsive controlled-release hydrogel is that sodium humate is a functional carrier component for forming a hydrogel network and realizing pH-responsive controlled release, and meanwhile, sodium humate is also used as an active component and has a synergistic interaction effect with 5-aminosalicylic acid. By means of the intelligent carrier, release of the medicine in the stomach is effectively inhibited, effective enrichment and continuous medicine release at the colon part are achieved, the local medicine concentration is remarkably improved, and an efficient and safe new strategy is provided for treatment of ulcerative colitis.

The invention discloses spleen-tonifying kidney-tonifying fat-regulating paste and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The invention relates to spleen-tonifying kidney-tonifying fat-regulating paste. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8-12 parts of herba epimedii, 8-12 parts of fructus lycii, 8-12 parts of fructus psoraleae, 8-12 parts of semen cuscutae, 8-12 parts of cassia twig, 8-12 parts of herba cistanche, 8-12 parts of radix morindae officinalis, 8-12 parts of rhizoma zingiberis, 8-12 parts of ginseng, 8-12 parts of radix astragali, 6-8 parts of fiveleaf gynostemma herb, 8-12 parts of poria cocos, 8-12 parts of plantago asiatica, 8-12 parts of rhizoma alismatis, 8-12 parts of rhizoma dioscoreae, 8-12 parts of pericarpium citri reticulatae, 8-12 parts of prepared rhizoma polygonati, 8-12 parts of radix rehmanniae preparata and 8-12 parts of semen asteris. The traditional Chinese medicine is prepared from 8-12 parts of tortoise plastron, 8-12 parts of crude dragon bone, 8-12 parts of oyster, 8-12 parts of magnet, 8-12 parts of amethyst and 8-12 parts of golden cypress. Through precise compatibility of monarch, minister, assistant and guide (warming kidney yang, tonifying spleen soil, nourishing kidney yin, promoting diuresis and turbid dampness, securing essence and qi, clearing heat and drying dampness), the whole effects of tonifying kidney and spleen, supporting healthy qi, promoting gasification, restoring transportation and transformation and removing turbid dampness and fat paste are achieved, and relapse is not prone to occurring.

The health-preserving conditioning tea is prepared from the following raw materials in parts by weight: 3 to 8g of earthworms, 2 to 9g of flos carthami, 4 to 7g of ground beetles, 5 to 10g of leeches, 1.5 to 6g of radix aucklandiae, 3 to 8g of herba verbenae, 2 to 5g of gadflies, 3 to 7g of arisaema cum bile, 6 to 10g of radix salviae miltiorrhizae, 4 to 8g of radix paeoniae rubra, 2 to 6g of bombyx batryticatus, 1.5 to 5g of scorpions and 4 to 9g of folium ginkgo. The conditioning tea has the beneficial effects that the conditioning tea not only can replace traditional western medicines and avoid drug resistance and side effects, but also is convenient to carry and take after being bagged, can relieve and reduce the symptoms of cardiovascular and cerebrovascular plaques, namely blockage, during long-term taking according to the treatment course, can prevent cardiovascular and cerebrovascular diseases, activate blood and promote menstruation, and can be used for treating cardiovascular and cerebrovascular diseases. The traditional Chinese medicine composition has the effects of tonifying qi, preserving health, reducing blood fat and blood pressure, and also can be used for treating diseases such as chest distress, chest pain, cardiac hypertrophy, mitral valve and tricuspid valve regurgitation, myocardial ischemia and the like.

Described herein are methods useful for the treatment of cancers in a canine subject with a pharmaceutical compositions comprising HDAC inhibitors, Rapamycin, Dasatinib, Lapatinib, Trametinib, Vorinostat, Imatinib, Crizotinib, Sorafenib, and combinations thereof. Also described herein are methods for identification of subjects with cancers that will benefit from administration of the pharmaceutical compositions comprising HDAC inhibitors, Rapamycin, Dasatinib, Lapatinib, Trametinib, Vorinostat, Imatinib, Crizotinib, Sorafenib, and combinations thereof. In certain aspects, the methods described herein further comprise administering a therapeutically effective amount of at least one additional anti-cancer agent.

The invention provides a traditional Chinese medicine composition for treating epilepsy as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The traditional Chinese medicine composition for treating epilepsy provided by the invention comprises the following raw materials in parts by weight: 5-15 parts of rhizoma acori graminei, 3-10 parts of earthworm, 5-15 parts of codonopsis pilosula, 3-10 parts of schisandra chinensis, 3-10 parts of scutellaria baicalensis, 5-15 parts of gastrodia elata, 5-15 parts of radix bupleuri, 5-15 parts of dragon bone and 5-15 parts of poria cocos. The traditional Chinese medicine composition provided by the invention aims at epilepsy, achieves the purpose of treating epilepsy through the effects of calming liver wind, breaking phlegm, dispersing blood stasis, tonifying kidney and treating epilepsy on the basis of the treatment thought of traditional Chinese medicine that disease treatment must be essential and deep understanding of disease mechanisms, and reduces possible side effects and recurrence risks at the same time. The traditional Chinese medicine composition provided by the invention has the effects of treating epilepsy, inducing resuscitation and replenishing essence and marrow, and has the advantages of good curative effect and small side effect when being used for treating epilepsy.

The invention provides a nerve soothing and mind stabilizing pill and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The preparation method comprises the following steps: cleaning, infiltrating, cutting, drying, performing high-pressure steam sterilization on genuine medicinal materials such as poria cocos, poria with hostwood, ginseng, polygala tenuifolia, rhizoma acori graminei and the like in a formula of the mind-tranquilizing and mind-tranquilizing pill, mixing and crushing at low temperature to obtain fine powder, adding refined honey to prepare pills, and finally coating with cinnabar powder to obtain the mind-tranquilizing and mind-tranquilizing pill. The contents of polygala-ketone III, 3, 6 '-dimustard acyl sucrose, ginsenoside Rb1, beta-asarone, dehydrotumoic acid, pachymic acid and calcium salt in the prepared nerve-soothing and mind-stabilizing pill are high, the loss of index components in the pelleting process is small, and the dissolution time limit and microbial limit of the pill meet the requirements of Chinese Pharmacopoeia of 2025 edition. The preparation process of the mind-tranquilizing and mind-stabilizing pill is stable, and the prepared mind-tranquilizing and mind-stabilizing pill can effectively improve cognitive impairment, inflammation and oxidative stress injury caused by insomnia.

The application belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to an acupoint sticking medicine for preventing and treating long-term postoperative cognitive impairment of elderly patients and a use method thereof. The traditional Chinese medicine composition of the acupoint sticking medicine comprises Huangrenshen, Baishao, Danggui, Guijianyu, Shichangpu, Yuanzhi, Tianzhuhuang, Longchi, Fushen, Mosha, Huoxiang and Pelian. Under the guidance of the traditional Chinese medicine meridian theory, the physiological characteristics of the elderly patients are combined with the long-term postoperative rehabilitation demand, so that the effective components of traditional Chinese medicine are absorbed through the skin and jointly play a superimposed treatment role. The acupoint sticking medicine has a definite effect on preventing and treating long-term postoperative cognitive impairment of elderly patients, can significantly improve the long-term postoperative cognitive function score of the elderly patients, improve the long-term postoperative life quality and sleep quality, and is beneficial to the long-term postoperative rehabilitation of the elderly patients.

The invention discloses a traditional Chinese medicine composition for scalds and burns as well as preparation and application thereof, and belongs to the technical field of traditional Chinese medicine treatment. The traditional Chinese medicine composition is prepared by combining raw materials including barks of barks of portulaca oleracea, barks of rubus corchorifolius, carbon crystals (coal crystals) and borneol according to a specific weight ratio, and raw tung oil is used as a matrix carrier. The preparation process is completed through the steps of raw material purification, drying, nanoscale crushing, precise proportioning, mixing and screening and the like, and the product is fine and uniform nanoscale powder. The traditional Chinese medicine composition is scientific and reasonable in formula, simple and controllable in preparation process and convenient and safe in medication mode, solves the problems of slow healing, obvious scars, easy infection, large side effects and the like of existing scald and burn treatment medicines, is suitable for various scenes such as family emergency, clinical medical treatment and outdoor operation, and has extremely high popularization and application values.

The application discloses a traditional Chinese medicine formula for treating endometriosis, which comprises the following components in the weight fractions: cassia twig 14-16 parts, five spirit fat 8-12 parts, raw safflower 4-8 parts, xiaosha 4-8 parts, blood 4-8 parts, leech 2-5 parts, white peony root 8-12 parts, ophiopogon 8-12 parts, uncaria 12-14 parts, amber 4-8 parts and licorice 4-8 parts. The application is innovatively combined with the combination of heart calming and liver regulating on the basis of the original Pingchongjiangni formula, that is, warming heart yang to calm the rushing qi, calming heart qi to lower the rushing qi, and calming liver qi to follow the rushing qi, so that the purpose of calming the rushing qi is achieved. The traditional Chinese medicine formula can not only effectively relieve the dysmenorrhea of the patients with endometriosis, but also improve the psychological state such as depression and anxiety, and still has certain curative effect after stopping the medicine for three months.

The invention relates to traditional Chinese medicine ointment for treating femoral head necrosis, and belongs to the technical field of ointment for treating femoral head necrosis. According to the traditional Chinese medicine ointment for treating femoral head necrosis, on the basis of five elements and five internal organs of a human body, under the precondition that the kidney is the innate, the necrotic femoral head is effectively recovered according to the pharmacological treatment principles of tonifying liver and kidney, strengthening muscles and bones, tonifying spleen qi, promoting blood circulation to arrest pain and astringing and promoting granulation. Meanwhile, the medicine takes effect quickly and is short in treatment course, so that the economic pressure of patients is greatly relieved.

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition and a traditional Chinese medicine decoction for treating insomnia, which have obvious curative effects and low toxic and side effects and have obvious curative effects on insomnia and dreaminess, palpitation and restlessness, anxiety and depression, chest and hypochondrium fullness and stuffiness and other symptoms. The traditional Chinese medicine composition is prepared from the following raw medicinal materials in parts by weight: 10-20 parts of radix bupleuri, 5-10 parts of scutellaria baicalensis, 15-20 parts of codonopsis pilosula, 9-15 parts of rhizoma pinelliae preparata, 20-30 parts of poria cocos, 15-30 parts of cassia twig, 10-20 parts of calcined ruddle, 20-30 parts of crude dragon bone, 25-45 parts of raw oyster shell, 15-25 parts of acanthopanax, 15-25 parts of poria with hostwood, 5-10 parts of fried spina date seed, 10-20 parts of honey-fried licorice root, 5-15 parts of stiff silkworm, 6-10 parts of cicada slough, 1-2 parts of scorpion and 10-15 parts of endothelium corneum gigeriae galli. , 10-15 parts of fingered citron, 15-30 parts of dark plum, 20-30 parts of white peony root and 5-15 parts of Chinese magnoliavine fruit. The scorpion is provided in a powder grinding form; the calcined ruddle, the crude dragon bone and the raw oyster shell are decocted with water and then mixed with the other raw medicinal materials, water is added for immersion and decoction for 2-3 times, decoction solutions are combined and mixed uniformly, and the traditional Chinese medicine decoction is obtained. The traditional Chinese medicine composition is prepared from traditional Chinese medicine decoction and scorpion powder.

This invention discloses a nasal topical medication application system, relating to the technical field of nasal topical medication application devices. To improve the medication application effect, the device includes a receiving bottle with a dispensing section at its top. Delivery pipes are fixed to the inner walls of both sides of the top of the receiving bottle via fixed supports. The delivery pipes are located at the center of the inner side of the dispensing section, and an airflow channel is provided between the delivery pipes and the dispensing section. The system includes the aforementioned medication application device, as well as a nasal topical medication formula and a preparation method for the formula. The formula includes the following components: seawater and purified water. This invention features a stirring mechanism. The user can press the connecting rod to apply an axial force to the rotating column. The sliding ball and the spiral groove form a sliding engagement, causing the rotating column to rotate, which in turn drives the stirring part to rotate, achieving stirring and avoiding uneven mixing of the drug components, thus improving the medication application effect.

The invention relates to the field of traditional Chinese medicine physiotherapy, and particularly discloses a composite physiotherapy matrix and a preparation method thereof.The composite physiotherapy matrix is prepared from, by mass, 12%-22% of pine-soot ink, 20%-35% of volcanic mud, 25%-35% of beewax and 18%-28% of traditional Chinese medicine mixed powder. The preparation method of the composite physiotherapy matrix comprises the steps of raw material pretreatment, beeswax melting, pine-soot ink, volcanic mud and traditional Chinese medicine mixture mixing, viscosity adjusting, mold filling and demolding, and thus the composite physiotherapy matrix is obtained. Through unique formula design and preparation process, pine-soot ink, volcanic mud, traditional Chinese medicines and beewax are organically combined, and the advantages of all the components are integrated. The pine-soot ink provides good permeability and biological activity; volcanic mud is rich in mineral substances, and has the effects of enhancing detoxification and regulation; the traditional Chinese medicines are precisely formulated according to different diseases, and targeted treatment is provided; and the beewax has the effects of shaping and heat preservation, so that the cost can be reduced, the curative effect can be remarkably improved, and remarkable innovativeness and market competitiveness are achieved.

Provided herein are methods and compositions for the treatment of cancer by modulating the microbiome to enhance the efficacy of immune checkpoint blockade. The microbiome may be modulated by the administration of butyrate and / or butyrate-producing bacteria. Also provided herein are methods of determining a response to an immune checkpoint inhibitor by identifying if a subject has a favorable microbial profile.

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating carbuncle and preparation method and application thereof, the traditional Chinese medicine composition comprises the following components in parts by weight: Cortex Periplocae 10-30 parts, Dragon Bone 3-5 parts, Borneol 0.5-2 parts, Tortoise Shell 0.5-2 parts, Zanthoxylum 0.2-0.5 parts, and Sesamum Indicum Oil 1000-2000 parts. The whole prescription is based on the prescription principles of clearing heat and resolving toxins, resolving stasis and detumescence, relieving inflammation and pain, and promoting blood circulation and generating new tissue. The Cortex Periplocae is the monarch herb for clearing heat and resolving toxins and relieving inflammation and pain. The Dragon Bone is the ministerial herb for nourishing blood and yin, resolving stasis and unblocking vessels. The Borneol is the auxiliary herb for promoting blood circulation and unblocking collaterals, assisting the monarch and ministerial herbs, enhancing the efficacy, and regulating immunity. The Tortoise Shell is the ministerial herb for guiding other herbs to the pain site to relieve swelling and pain. The Borneol and Zanthoxylum are used together to have the effects of promoting blood circulation and unblocking collaterals, relieving pain, dispelling wind and cold, and removing dampness and pain. The combination of the herbs has the effects of promoting blood circulation and resolving stasis, resolving toxins and generating new tissue, and removing blood stasis, and is used for treating carbuncle to achieve good efficacy.

The invention relates to a traditional Chinese medicine composition for treating diabetic nephropathy and a preparation method thereof, and relates to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition for treating diabetic nephropathy comprises the following raw materials by weight: 25-35 parts of prepared rehmannia root, 25-35 parts of dogwood, 15-20 parts of Chinese yam, 15-20 parts of oyster, 7-12 parts of Poria cocos and 7-12 parts of white peony root. According to the present invention, the existing decoction-Jiji decoction has a certain alleviating effect on diabetic nephropathy, and further improvement is performed on the basis of the existing decoction formula, such that after the ossa draconis and the radix aconiti lateralis preparata in the original decoction are removed, the reduced pressure reflux extraction under the specific parameters is adopted so as to achieve the effect of treating diabetic nephropathy; the treatment effect of the obtained traditional Chinese medicine composition on diabetic nephropathy can be remarkably improved, a new means is provided for treatment of patients with diabetic nephropathy, and the application prospect is wide.

The application discloses a traditional Chinese medicine composition with the effect of treating infantile recurrent respiratory tract infection and a preparation method thereof. Through a large amount of clinical practice, the application selects radix pseudostellariae, fried atractylodes, fried rhizoma atractylodis, agastache, levisticus, lonicera, radix scrophulariae, carbonized wheat bran, calcined osseous, ephedra root as raw materials, and is prepared into an oral or external dosage form according to weight ratio. The application has the effects of transporting the spleen, preventing the invasion of pathogenic factors, and consolidating the surface and stopping sweating, and is used for infantile recurrent respiratory tract infection with the syndrome of the spleen failing to transport and the lung and defensive system failing to consolidate. The application is verified by clinical tests, has remarkable curative effect, no toxic side effect, and good safety. Animal experiment researches show that the traditional Chinese medicine composition can effectively relieve the chronic inflammation level of model mice, improve the airway epithelial barrier damage, improve the body's ability to resist pathogenic factors, and reduce the risk of infection. The application can fill the market blank of treating infantile recurrent respiratory tract infection diseases based on the theory of 'four seasons with the spleen being strong and not being invaded by pathogenic factors' and 'the spleen being strong is not about tonifying but about transportation', and has great development prospect.

The invention discloses traditional Chinese medicine combined powder for rapidly treating various burns and scalds, and relates to the technical field of traditional Chinese medicine formulas. Traditional Chinese medicine combined powder for rapidly treating various burns and scalds is characterized in that the active ingredients of the powder comprise 6-10 parts by weight of polygonum cuspidatum, 3-9 parts by weight of coptis chinensis, 4-10 parts by weight of paris polyphylla, 6-12 parts by weight of rhizoma bletillae, 15-30 parts by weight of calcined dens draconis, 3-9 parts by weight of spar and 0.1-0.3 part by weight of pearl. The combined medicine powder has the effects of clearing away heat and toxic materials, promoting tissue regeneration, relieving pain, promoting wound repair and enhancing local microcirculation of the wound, the medicine powder generally needs to be combined with sesame oil for use, the core components of the medicine powder, namely polygonum cuspidatum and coptis chinensis, synergistically exert broad-spectrum antibacterial and antioxidant effects, and paris polyphylla and rhizoma bletillae enhance the barrier function of the wound; the calcined dens draconis and the kyanite promote activation of a calcium ion channel, and the pearl can regulate and control ordered deposition of collagen and reduce scar hyperplasia.

The invention belongs to the technical field of medicinal material screening, and relates to a traditional Chinese medicine compound for treating attention deficit hyperactivity disorder and a screening method thereof. The screening method comprises the following steps: constructing a drug use database of ADHD; performing statistics and association rule analysis on frequency, property and flavor tropism and efficacy of the traditional Chinese medicines to obtain a high-frequency traditional Chinese medicine composition; screening ADHD disease targets and establishing a target set; performing clustering analysis and integration on the high-frequency traditional Chinese medicine composition to obtain a core medicine composition; constructing candidate traditional Chinese medicine compounds through reverse network pharmacological analysis; evaluating the efficacy of the candidate traditional Chinese medicine compound through animal experiments, and screening out the optimal traditional Chinese medicine compound. According to the method, an O-R-S analysis mode is constructed through data mining and reverse network pharmacology, traditional Chinese medicine compound screening and evaluation processes of ADHD and candidate compounds with better comprehensive performance are optimized, and a reference scheme with data support and mechanism basis is provided for traditional Chinese medicine clinical treatment and new drug research and development of ADHD.