60 results about "Dermatological disorders" patented technology

The invention provides a dermatoscope image segmentation method based on an attention mechanism and UNet, and belongs to the technical field of medical image segmentation of image segmentation. The technical problem that a traditional method is insufficient in accuracy in lesion region segmentation is solved. According to the technical scheme, the method comprises the following steps: 1, data preprocessing: carrying out image denoising, image enhancement and division on a data set; step 2, constructing a dermatoscope image segmentation network based on an attention mechanism and UNet; 3, putting the processed skin disease image training set into a dermatoscope image segmentation network model based on an attention mechanism and UNet for training to obtain an optimal model; and 4, after training is completed, inputting the test set into the optimal model, and detecting a focus segmentation result in the skin disease image. The method has the advantage that high segmentation accuracy and robustness are guaranteed.

The utility model relates to an adjustable cervical vertebra fixing traction brace which comprises a front half neck support and a rear half neck support. A lower jaw support is arranged on the top of the front half neck support, and sliding protection plates are arranged on the two sides of the lower jaw support respectively. The end, away from the lower jaw support, of the sliding protection plate is further provided with a sliding arc groove. The sliding protection plate is movably connected with the neck front half support through a sliding shaft; an arc-shaped strip with teeth and a height adjusting knob are fixedly mounted on the front half neck support, and an inflating device is further arranged on the rear half neck support; the adjustable neck support has the advantages that the height of the lower jaw support on the front half neck support can be adjusted, and the adjustable neck support can be used by patients with different neck lengths; the arrangement of the fence through holes and the hollowed-out air holes can facilitate ventilation and perspiration of the neck, so that skin diseases and pressure sores caused by the fact that the interior is not ventilated are avoided; meanwhile, the inflation device is arranged, so that traction treatment on the patient can be achieved, and the comfort of the patient can be improved.

The utility model relates to the technical field of medical auxiliary instruments, and particularly discloses a clinical dermatosis applicator which comprises a piston rod, a pushing handle, a medicine feeding piston and a medicine applying mechanism. The medicine applying mechanism comprises medicine applying grab handles, medicine applying connecting shafts, a medicine applying roller, a medicine storage pipe and a medicine injecting pipe, the two medicine applying grab handles are fixedly connected with the medicine storage pipe, the two medicine applying connecting shafts are fixedly connected with the corresponding medicine applying grab handles, the medicine applying roller is arranged between the two medicine applying grab handles, and the medicine injecting pipe is communicated with the medicine storage pipe; one end of the medicine feeding piston and one end of the piston rod are embedded in the medicine storage pipe. The medicine applicator is simple in structure, easy to operate and capable of being processed and prepared through plastic materials, each medicine applicator can be used in a disposable mode, cost is low, meanwhile, a user does not need to repeatedly clean the medicine applicator, operation is easier and more convenient, and the risk that medicine is polluted does not need to be worried about.

The invention provides a multi-agent collaborative semantic transformation framework for a rare disease recognition problem, and belongs to the technical field of artificial intelligence and medical image analysis. According to the method, the problems of scarcity of marked data and difficulty in cross-domain knowledge migration in rare disease recognition are solved. The method comprises the steps that S1, a multi-agent parallel network architecture is constructed, each agent is provided with a special semantic focusing module, and diversified features are extracted from different attribute perspectives; s2, a cooperative gating mechanism with dynamic temperature parameters is realized, and the cooperative and competitive relationship between intelligent agents is balanced in a self-adaptive manner; s3, applying a double-constrained cross-domain semantic alignment strategy to ensure that the converted semantic features are consistent with the original features and keep diversity at the same time; s4, adopting a progressive training strategy and a semantic consistency loss function to reduce an overfitting phenomenon in cross-domain knowledge migration; and S5, classifying and identifying rare diseases through multi-agent cooperation, and applying source domain knowledge to a target domain. The method is prominent in medical image application, the accuracy rate of identifying rare skin diseases by using only common skin disease data reaches 52.13%, and the method is remarkably superior to an existing method. The framework has wide applicability in cross-domain zero sample learning tasks, is particularly suitable for application in the field with definite definition of semantic attributes, and provides a new solution for diagnosis of rare diseases in medical images.

1. The name of the design product: plasma therapy instrument (Liangdian Kang). 2. The use of the design product: for the treatment of skin diseases, wounds and infections in pets. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The present invention discloses compounds according to Formula I:wherein R1a, R1b, R1c, R2a, W1, W2, X1, X2, X3, Y, and Z are as defined herein.The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and / or treatment of inflammatory diseases, autoinflammatory diseases, autoimmune diseases, proliferative diseases, fibrotic diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation, diseases involving impairment of bone turnover, diseases associated with hypersecretion of IL-6, diseases associated with hypersecretion of TNFα, interferons, IL-12 and / or IL-23, respiratory diseases, endocrine and / or metabolic diseases, cardiovascular diseases, dermatological diseases, and / or abnormal angiogenesis associated diseases by administering the compound of the invention.

There is provided an aqueous personal care rinse-off formulation, the aqueous personal care rinse-off formulation comprising: a dermatologically acceptable vehicle; a dermatologically acceptable cleansing surfactant; and a gradient polymer comprising: 5%-35% by weight of structural units of (meth) acrylic acid; 35 wt% to 65 wt% of a structural unit of C1-8 alkyl (meth) acrylate; gt; 10% to 30% by weight of structural units of a dedicated associative monomer having structure I wherein R1 is a linear saturated C12-26 alkyl group; wherein R2 is hydrogen or a methyl group, and wherein n is from 10 to 30; 0.01 wt% to 2 wt% of a structural unit of a polyethylenically unsaturated monomer; wherein the gradient polymer comprises lt; 0.05% by weight of structural units of sulfonated monomers; wherein the polymer comprises lt; 0.02% by weight of structural units of a monomer having structure II wherein R3 is-H or-CH3; r4 is-H or a-C1-4 alkyl group; r5 is a-C1-4 alkyl group; a is 0 to 50; b is 0 to 20; c is 0 to 50; a + c is 1 to 100 and d is 1 to 4; and wherein the gradient polymer has a gradient polymer morphology.

The present invention provides a liposomal topical formulation or a liposomal topical formulation base having barrier-forming siliconic components, methods for making the same, and methods for using the same in the treatment of dermatological diseases and conditions, including male pattern baldness.

The application belongs to the technical field of medical image processing, and particularly relates to a human limb skin disease area evaluation method, device and system. The method comprises the following steps: collecting multi-view images of a target limb, adjacent view angles of the multi-view images containing overlapping areas; generating a three-dimensional point cloud of the target limb based on the multi-view images; constructing a cylindrical model with a radius changing along a limb axis based on the three-dimensional point cloud; projecting the multi-view images to the cylindrical model, and selecting pixels projected to the same position of the model based on an evaluation function, so that the model surface is attached with image texture; and unfolding the cylindrical model with the texture into a two-dimensional plane image for evaluating the skin disease area. The application realizes high-precision and high-fidelity lesion area evaluation without expensive three-dimensional scanning equipment.

This invention provides a urine absorbent material holding device that eliminates issues such as shame and resistance to wearing diapers, skin diseases caused by the large contact area, discomfort due to high humidity inside the diaper, urine odor leakage, inefficiency due to incomplete use of absorbent material, unattractive appearance, diaper slippage due to the weight of urine, and high costs. [Solution] The device comprises a bag-shaped holding part 3 for holding a urine absorbent inside, with the front part being openable and closable and an insertion hole 2 at the rear part; a locking piece extending from the top of the insertion hole 2 into the holding part 3; an annular belt part 5 provided at the rear upper part of the holding part 3; a right support part connected to the lower end of the holding part 3 and the right side of the belt part 5; and a left support part connected to the lower end of the holding part 3 and the left side of the belt part 5. A locking member 8 is provided on the portion of the locking piece 4 that extends into the holding part 3, and the locking member 8 locks the urine absorbent.

The present invention refers to a composition including fermented supernatant of Lactobacillus casei or paracasei species. The species is characterized by having in its DNA genome at least one DNA sequence essentially identical to one of the sequences selected from the group consisting of: SEQ ID NO: 1 to 5, and proper diluents and / or carriers and / or excipients. The composition can be used in the treatment and / or prevention of skin and / or dermatological diseases related to inflammation, allergic reactions, contact hypersensitivity reactions and intolerance, excessive sebaceous secretion, exfoliation or microbial dysbiosis, preferably of the epidermis.

The invention relates to the field of foot bath appliances, in particular to a novel foot bath device which comprises a shell, a phototherapy assembly is arranged on a first cover plate, massage assemblies are arranged on the two sides of the interior of the shell, adjusting assemblies are arranged on the two sides of the shell, and the adjusting assemblies are used for adjusting the distance between the massage assemblies. A nerve electrical stimulation pad and a limiting plate are sequentially stacked on the front face of an inner cavity of the shell, a through hole is formed in the limiting plate, a massage electrode is arranged on the front face of the nerve electrical stimulation pad, the front face of the massage electrode penetrates through the through hole, and a magnetic block is arranged on the front face of the limiting plate. The device integrates the functions of foot bath, massage, electrical stimulation, phototherapy and magnetic therapy, meets different use requirements of users, can achieve the effects of relaxation, treatment and health care at the same time, is suitable for wider crowds and health problems such as arthritis, diabetic foot, skin diseases and chronic pain, provides multiple modes and function selections, and is suitable for popularization and application. And the user experience is richer.

1. Name of the Design Product: Ultraviolet Therapeutic Instrument (308nm). 2. Use of the Design Product: A physical therapy instrument for treating skin diseases. 3. Design Key Points of the Design Product: Lies in the shape of the product. 4. Picture or Photograph Most Illustrating the Design Key Points: Perspective view. 5. The bottom surface of the Design Product is a part that is not easily visible or invisible during use, and the bottom view is omitted.

The present invention relates to a composition comprising a photosensitizer use in prevention or treatment of dermatological disease in a patient, wherein the composition is used in the following order of steps: (a) topical application or subcutaneous injection of said composition to an area of the skin of said patient, (b) exposure of at least said area of the skin to light with a wavelength spectrum similar or identical to sun light for a duration of 30 min to 5 hours, and (c) exposure of at least said area of the skin to light of a wavelength spectrum comprising only one maximum in the absorbance spectrum of said photosensitizer as well as to methods of treating dermatological disease using the outlined steps and kits of parts comprising such compositions and light sources suitable to apply the respectively indicated light.

This invention relates to a phototherapy detection device and system for skin diseases. The phototherapy detection device includes a base unit, a housing unit, a multi-hole testing unit, a light source adjustment unit, a light source mounting unit, at least one first transmission unit, at least two second transmission units, and a drive unit. Its advantages are: the base unit enables the movement and stable positioning of the entire device, facilitating its movement and fixation above the patient's skin; the housing unit provides a closed installation space for each internal unit, protecting the transmission mechanism from external interference, and the top through-slot structure provides a guiding channel for the horizontal movement of the light source adjustment unit; the bottom structure of the multi-hole testing unit forms a tight fit with the patient's skin, preventing light leakage due to gaps during testing; and the cooperation between the light source adjustment unit and the multi-hole testing unit enables the positioning and stable holding of the light source among the various testing holes.

Disclosed herein are systems and methods of generating skin disease treatment classes. Also described herein are methods for using the methods described herein for assessing potential response to therapies for treating skin diseases or skin conditions.

The present disclosure provides methods for assessing a skin of a subject based on gene expression analysis. In an aspect, a method for assessing a skin of a subject comprises: (a) assaying a biological sample obtained or derived from the subject to produce a data set comprising gene expression measurements of the biological sample from each of a plurality of inflammatory skin disease-associated genomic loci, e.g., lupus, psoriasis, atopic dermatitis, and / or systemic sclerosis (scleroderma) disease-associated genomic loci, wherein the plurality of inflammatory skin disease-associated genomic loci comprises at least one gene selected from the group listed in Table 1, Table 2, Table 4A-1 to 4A-20, Table 4B-1 to 4B-28, Table 4C, Table 4D, or any combination thereof; (b) analyzing the data set to classify the skin of the subject as indicative of the inflammatory skin-disease associated disease state; and (c) electronically outputting a report indicative of the classification of the skin of the subject as indicative of the inflammatory skin-disease associated disease state.

The invention provides a nursing parameter adaptation evaluation system and method based on image recognition of child states. The system comprises an image acquisition and analysis module, a discomfort evaluation module, a parameter correction and analysis module and a nursing parameter adaptation module. The image acquisition and analysis module is used for acquiring abnormal region parameters and predicting discomfort parameters; the discomfort evaluation module is used for obtaining actual discomfort parameters and calculating to obtain implicit discomfort parameters; the parameter correction analysis module is used for obtaining an abnormal region approaching parameter and correcting an implicit discomfort parameter; and the nursing parameter adaptation module is used for obtaining an adaptation coefficient as an adaptation evaluation result. The technical problem that in the prior art, child skin disease nursing parameter setting lacks personalized adaptation, and consequently the nursing effect is poor is solved, and the technical effects that intelligent adaptation of nursing parameters is achieved through multi-dimensional image analysis, and the child skin disease nursing effect is improved are achieved.

This disclosure relates to an embodiment of the use of tocotrienols in pharmaceutical, veterinary, or cosmetic applications, particularly in cosmetic formulations, whereby stabilizing tocotrienols does not impair their function in the skin. Specifically, this disclosure relates to the modification, molecular stabilization, and penetration properties of tocotrienols in human skin using nicotinic acid. The compounds and compositions of this subject matter are useful in the medical, veterinary, or cosmetic industries as a preventative, therapeutic, or treatment of dermatological diseases or skin disorders, as a treatment or treatment of acne or seborrheic dermatitis, or as anti-aging agents.

Dermatological treatments and systems employing cooling, topicals, and / or abrasion are disclosed herein. The system can include a cold plate and a suspension assembly tip. The suspension assembly tip can be selectively coupleable to the cold plate. The suspension assembly tip can include a suspension tip and a suspension. The suspension tip can include a contact surface that can be contacted onto a patient's skin to provide a treatment. The suspension can couple to both the cold plate and to the suspension tip. The suspension can be thermally conductive so as to closely thermally couple the suspension tip to the cold plate, or the suspension tip can have a low thermal conductivity so as to not closely thermally coupled the suspension tip to the cold plate.

The present invention refers to a composition including a fermented supernatant of Lactobacillus casei or paracasei species The species is characterized by having in its DNA genome at least one DNA sequence essentially identical to one of the sequences selected from the group consisting of: SEQ ID No 1 to 5, and proper diluents and / or carriers and / or excipients. The compositions can be used in the treatment and / or prevention of skin and / or dermatological diseases related to inflammation, allergic reactions, contact hypersensitivity reactions and intolerance, excessive sebaceous secretion, exfoliation or microbial dysbiosis, preferably of the epidermis.

Topically applied compositions comprising TRPV3 Inhibitors such as KM-001 significantly reduce the severity of dermatological lesions, pruritus, and combinations thereof in patients suffering from dermatological disorders such as keratodermas, lichen simplex chronicus, and ichthyoses.

Systems and methods for predicting cosmetic dermatology treatment plans and human skin characteristics with artificial intelligence are disclosed. According to an aspect, a system comprises one or more processors and memory comprising an expert inference engine. The expert inference engine is configured to receive data that indicates skin characteristics of a patient. Further, the expert inference engine is configured to maintain an expert system knowledge base for operating a therapeutic laser. The expert inference engine is also configured to determine settings for the therapeutic laser based on the expert system knowledge base and the skin characteristics of the patient. Further, the expert inference engine is configured to a user interface configured to present the determined settings for treating the patient.

The present disclosure relates to bispecific antigen binding molecules targeting IL-13 and OX40L, antibodies targeting OX40L, pharmaceutical compositions comprising the same, and methods of treatment using the same, e.g. in treating a dermatological disease or condition such as atopic dermatitis.

The present invention discloses the use of Lactobacillus casei Zhang in preparing a preparation for treating skin diseases, relating to the technical field of microbial probiotic preparations. The present invention provides the use of Lactobacillus casei Zhang in preparing a preparation for treating or alleviating psoriasis. The Lactobacillus casei Zhang has a deposit number of CGMCC No. 5469. The Lactobacillus casei Zhang of the present invention has an alleviating effect on the symptoms of psoriasis, can inhibit the weight loss trend of psoriasis patients, and reduce the spleen index. It can be used to prepare a preparation for alleviating psoriasis. It can also be used as a microecological preparation in medicines, fermented foods, or health products, providing a potential option for developing new psoriasis treatment methods.

Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, opthamological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. One embodiment consists of a method to synthesize a porphyrin with a defined arrangement of meso-substituents and then converting this porphyrin system to a chlorin system by dihydroxylation or reduction, and if more than one isomer is formed separate them by chromatography either on normal or reversed phase silica. In another embodiment the substituents on the porphyrin are selected to direct the reduction or dihydroxylation to the chlorin so that a certain isomer is selectively formed. Another embodiment is to provide amphiphilic compounds with a higher membrane affinity and increased PDT-efficacy. In other embodiments the nucleophilic substitution on pentafluorophenyl-substituted tetrapyrroles is used to obtain compounds with a high PDT-efficacy. In another embodiment substituents are identified that via their steric and / or electronic influence direct the dihydroxylation or reduction with diimine so that one isomer is favored. Another embodiment consists of formulating the desired tetrapyrrole photosensitizer into a pharmaceutical formulation to be injected into the body avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.

1. The name of the product under this design: Home phototherapy device. 2. Purpose of the product with this design: The product with this design is used for the treatment of skin diseases, pain therapy, health care, anti-aging, beauty, skin care and hair care. 3. The key design point of this product lies in the shape of the product's appearance design. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.