30 results about "Dermatological disorders" patented technology

The invention provides a multi-agent collaborative semantic transformation framework for a rare disease recognition problem, and belongs to the technical field of artificial intelligence and medical image analysis. According to the method, the problems of scarcity of marked data and difficulty in cross-domain knowledge migration in rare disease recognition are solved. The method comprises the steps that S1, a multi-agent parallel network architecture is constructed, each agent is provided with a special semantic focusing module, and diversified features are extracted from different attribute perspectives; s2, a cooperative gating mechanism with dynamic temperature parameters is realized, and the cooperative and competitive relationship between intelligent agents is balanced in a self-adaptive manner; s3, applying a double-constrained cross-domain semantic alignment strategy to ensure that the converted semantic features are consistent with the original features and keep diversity at the same time; s4, adopting a progressive training strategy and a semantic consistency loss function to reduce an overfitting phenomenon in cross-domain knowledge migration; and S5, classifying and identifying rare diseases through multi-agent cooperation, and applying source domain knowledge to a target domain. The method is prominent in medical image application, the accuracy rate of identifying rare skin diseases by using only common skin disease data reaches 52.13%, and the method is remarkably superior to an existing method. The framework has wide applicability in cross-domain zero sample learning tasks, is particularly suitable for application in the field with definite definition of semantic attributes, and provides a new solution for diagnosis of rare diseases in medical images.

1. The name of the design product: plasma therapy instrument (Liangdian Kang). 2. The use of the design product: for the treatment of skin diseases, wounds and infections in pets. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

There is provided an aqueous personal care rinse-off formulation, the aqueous personal care rinse-off formulation comprising: a dermatologically acceptable vehicle; a dermatologically acceptable cleansing surfactant; and a gradient polymer comprising: 5%-35% by weight of structural units of (meth) acrylic acid; 35 wt% to 65 wt% of a structural unit of C1-8 alkyl (meth) acrylate; gt; 10% to 30% by weight of structural units of a dedicated associative monomer having structure I wherein R1 is a linear saturated C12-26 alkyl group; wherein R2 is hydrogen or a methyl group, and wherein n is from 10 to 30; 0.01 wt% to 2 wt% of a structural unit of a polyethylenically unsaturated monomer; wherein the gradient polymer comprises lt; 0.05% by weight of structural units of sulfonated monomers; wherein the polymer comprises lt; 0.02% by weight of structural units of a monomer having structure II wherein R3 is-H or-CH3; r4 is-H or a-C1-4 alkyl group; r5 is a-C1-4 alkyl group; a is 0 to 50; b is 0 to 20; c is 0 to 50; a + c is 1 to 100 and d is 1 to 4; and wherein the gradient polymer has a gradient polymer morphology.

The application belongs to the technical field of medical image processing, and particularly relates to a human limb skin disease area evaluation method, device and system. The method comprises the following steps: collecting multi-view images of a target limb, adjacent view angles of the multi-view images containing overlapping areas; generating a three-dimensional point cloud of the target limb based on the multi-view images; constructing a cylindrical model with a radius changing along a limb axis based on the three-dimensional point cloud; projecting the multi-view images to the cylindrical model, and selecting pixels projected to the same position of the model based on an evaluation function, so that the model surface is attached with image texture; and unfolding the cylindrical model with the texture into a two-dimensional plane image for evaluating the skin disease area. The application realizes high-precision and high-fidelity lesion area evaluation without expensive three-dimensional scanning equipment.

This invention provides a urine absorbent material holding device that eliminates issues such as shame and resistance to wearing diapers, skin diseases caused by the large contact area, discomfort due to high humidity inside the diaper, urine odor leakage, inefficiency due to incomplete use of absorbent material, unattractive appearance, diaper slippage due to the weight of urine, and high costs. [Solution] The device comprises a bag-shaped holding part 3 for holding a urine absorbent inside, with the front part being openable and closable and an insertion hole 2 at the rear part; a locking piece extending from the top of the insertion hole 2 into the holding part 3; an annular belt part 5 provided at the rear upper part of the holding part 3; a right support part connected to the lower end of the holding part 3 and the right side of the belt part 5; and a left support part connected to the lower end of the holding part 3 and the left side of the belt part 5. A locking member 8 is provided on the portion of the locking piece 4 that extends into the holding part 3, and the locking member 8 locks the urine absorbent.

The present invention relates to a composition comprising a photosensitizer use in prevention or treatment of dermatological disease in a patient, wherein the composition is used in the following order of steps: (a) topical application or subcutaneous injection of said composition to an area of the skin of said patient, (b) exposure of at least said area of the skin to light with a wavelength spectrum similar or identical to sun light for a duration of 30 min to 5 hours, and (c) exposure of at least said area of the skin to light of a wavelength spectrum comprising only one maximum in the absorbance spectrum of said photosensitizer as well as to methods of treating dermatological disease using the outlined steps and kits of parts comprising such compositions and light sources suitable to apply the respectively indicated light.

This invention relates to a phototherapy detection device and system for skin diseases. The phototherapy detection device includes a base unit, a housing unit, a multi-hole testing unit, a light source adjustment unit, a light source mounting unit, at least one first transmission unit, at least two second transmission units, and a drive unit. Its advantages are: the base unit enables the movement and stable positioning of the entire device, facilitating its movement and fixation above the patient's skin; the housing unit provides a closed installation space for each internal unit, protecting the transmission mechanism from external interference, and the top through-slot structure provides a guiding channel for the horizontal movement of the light source adjustment unit; the bottom structure of the multi-hole testing unit forms a tight fit with the patient's skin, preventing light leakage due to gaps during testing; and the cooperation between the light source adjustment unit and the multi-hole testing unit enables the positioning and stable holding of the light source among the various testing holes.

The present disclosure provides methods for assessing a skin of a subject based on gene expression analysis. In an aspect, a method for assessing a skin of a subject comprises: (a) assaying a biological sample obtained or derived from the subject to produce a data set comprising gene expression measurements of the biological sample from each of a plurality of inflammatory skin disease-associated genomic loci, e.g., lupus, psoriasis, atopic dermatitis, and / or systemic sclerosis (scleroderma) disease-associated genomic loci, wherein the plurality of inflammatory skin disease-associated genomic loci comprises at least one gene selected from the group listed in Table 1, Table 2, Table 4A-1 to 4A-20, Table 4B-1 to 4B-28, Table 4C, Table 4D, or any combination thereof; (b) analyzing the data set to classify the skin of the subject as indicative of the inflammatory skin-disease associated disease state; and (c) electronically outputting a report indicative of the classification of the skin of the subject as indicative of the inflammatory skin-disease associated disease state.

This disclosure relates to an embodiment of the use of tocotrienols in pharmaceutical, veterinary, or cosmetic applications, particularly in cosmetic formulations, whereby stabilizing tocotrienols does not impair their function in the skin. Specifically, this disclosure relates to the modification, molecular stabilization, and penetration properties of tocotrienols in human skin using nicotinic acid. The compounds and compositions of this subject matter are useful in the medical, veterinary, or cosmetic industries as a preventative, therapeutic, or treatment of dermatological diseases or skin disorders, as a treatment or treatment of acne or seborrheic dermatitis, or as anti-aging agents.

Dermatological treatments and systems employing cooling, topicals, and / or abrasion are disclosed herein. The system can include a cold plate and a suspension assembly tip. The suspension assembly tip can be selectively coupleable to the cold plate. The suspension assembly tip can include a suspension tip and a suspension. The suspension tip can include a contact surface that can be contacted onto a patient's skin to provide a treatment. The suspension can couple to both the cold plate and to the suspension tip. The suspension can be thermally conductive so as to closely thermally couple the suspension tip to the cold plate, or the suspension tip can have a low thermal conductivity so as to not closely thermally coupled the suspension tip to the cold plate.

The present invention relates to a novel pharmaceutical composition comprising spilanthol for use in the treatment of dermatological diseases associated with Demodex folliculorum and / or Demodex brevis and a preparation method thereof.

1. Name of the product in this design: Low-energy X-ray radiotherapy device (XT-5601). 2. Purpose of this design: For the treatment of skin diseases. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

Disclosed herein are methods, compounds, and compositions for treating or preventing inflammasome-mediated dermatological diseases or conditions.

Provided herein are methods for treating or preventing inflammatory skin disorders, such as Hidradenitis suppurativa, by administering to a subject having or at risk of developing the inflammatory skin disorder an agent that inhibits NK cell activity.

The present invention relates to esters of Formula (I) or a pharmaceutically acceptable salt thereof, and their use as a medicament, in particular for the treatment of dermatological diseases or skin cancers. The present invention further relates to use of esters of Formula (I) or a pharmaceutically acceptable salt thereof in cosmetic and nutritive compositions for preventing or reducing signs of aging in healthy subjects.

Disclosed herein compositions of polysaccharides chemically cross-linked by aromatic dialdehydes. The compositions may be in form of polymeric sheets for a variety of applications. Disclosed also nano-sized particles comprising the polysaccharide chemically cross-linked by aromatic dialdehydes. The nano-sized particles may further comprise lipids and surfactants. Intranasal delivery of the nano-sized particles enables delivery of biologically active agents into the brain. Topical and transdermal delivery of the nano-sized particles enables delivery of biologically active agents for treatment of systemic or dermatological disorders. Methods of manufacturing and uses of the compositions are also disclosed.

The application discloses an antibody or antigen binding fragment thereof against CK17, an antibody conjugate, a nucleic acid, a vector, a cell and application thereof, and relates to the technical field of antibody preparation.The antibody or antigen binding fragment thereof against CK17 provided by the application has good binding activity and affinity to CK17 protein, so that a detection product based on the CK17 protein marker can be developed, such as a detection reagent, a kit or a chip. The sensitivity and specificity of detection can be improved by using the antibody or antigen binding fragment thereof against CK17 to detect CK17. The antibody or antigen binding fragment thereof against CK17 can be used for early warning, diagnosis, efficacy evaluation and prognosis of diseases taking the CK17 protein as a marker. The application provides more protein selection for detection of the CK17 protein, early warning, diagnosis, efficacy evaluation and prognosis of epithelial tumors and skin diseases.

The present invention relates to a highly sensitive nested multiplex PCR-based primer panel for the detection of Lumpy Skin Disease Virus (LSDV) in a biological sample obtained from bovine species and livestock animals In particular, the present invention provides a nested multiplex detection primer panel and a kit comprising the same, for the detection of Lumpy Skin Disease Virus (LSDV) and its variants thereof. The present invention also provides a multiplex primer panel for the PCR whole genome amplification and genotyping of Lumpy Skin Disease Virus (LSDV) to obtain genomic data, which can be useful in tracking the evolution of the Lumpy Skin Disease virus and correlating with disease severity. Therefore, the present invention emphasizes its utility in veterinary diagnostics, epidemiological studies, and disease management strategies related to vaccine development for Lumpy Skin Disease Virus (LSDV) infections in livestock.

1. The name of the design product: Wood lamp (for veterinary use). 2. The use of the design product: The design product is used for the tool of animal skin disease examination. 3. The design points of the design product: in shape. 4. The picture or photo that can best show the design points: perspective drawing.

The present disclosure relates to bispecific antigen binding molecules targeting IL-13 and OX40L, antibodies targeting OX40L, pharmaceutical compositions comprising the same, and methods of treatment using the same, e.g. in treating a dermatological disease or condition such as atopic dermatitis.

Provided 4-pyrazolyl-N-heteroarylpyrimidin-2-amine compounds as potent TYK2 / JAK1 / JAK2 inhibitors with low systemic exposures when applied topically. Thus, these compounds, and compositions are useful as topical treatment of dermatological disorders related to JAK1 / JAK2 / TYK2 such as atopic dermatitis, psoriasis, hives, alopecia areata, vitiligo, hidradenitis suppurativa, hand eczema, necrobiosis lipoidica, non-sclerotic cutaneous chronic graft-versus-host disease, hand dermatitis, or Lichen Planus.

1. Name of the product in this design: Low-energy X-ray radiotherapy device (XT-5600). 2. Purpose of this design: For the treatment of skin diseases. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses a blending method for adjusting skin disease plaster according to humidity, and belongs to the technical field of plaster compositions.The method comprises the steps that under the preset temperature and humidity, polyethylene glycol is added into a mixture containing multiple matrixes in batches, a pre-prepared mixture of hydroxypropyl methyl cellulose and carbomer is added in three times, and the mixture is stirred to be uniform; performing variable-speed stirring to a transparent gel state; and slowly adding a mixture of polysorbate and polyoxyethylene sorbitan monooleate which are heated to a preset temperature into the colloidal mixture under the condition of controlling the temperature difference, and adding a trehalose aqueous solution for stirring to obtain the target paste. Through the scheme of the invention, the expansion degree fluctuation of the paste with different humidity can be reduced, and the stability is improved.

The present invention relates to an aqueous cosmetic or dermatological composition comprising: a) at least one merocyanine corresponding to the following formula (3) and also the geometric isomer form thereof, in particular E / E-or E / Z-geometric isomer form: formula (I) wherein: A is-O-or-NH-; r is a C1-C22 alkyl group, a C2-C22 alkenyl group, a C2-C22 alkynyl group, a C3-C22 cycloalkyl group or a C3-C22 cycloalkenyl group, said group being possibly intercalated with one or more O; the amount is less than 3% by weight relative to the total weight of the composition; and b) at least one water-soluble organic UV screening agent.

The present invention relates to a botanical composition having antioxidant, antiproliferative, anti-inflammatory, regenerative, and cicatrogenic activity in the skin and dermis. The present invention also relates to a dermatological preparation comprising the botanical composition and a suitable pharmaceutically acceptable excipient. Furthermore, the present invention relates to the botanical composition and dermatological preparation for medical use in the treatment of dermatological disorders and / or skin lesions in humans or animals. The present invention also relates to the cosmetic use of the botanical composition and dermatological preparation of the present invention. Furthermore, the present invention relates to an ophthalmological product comprising the botanical composition.

The invention belongs to the technical field of medical image processing, and particularly relates to a skin ulcer traditional Chinese medicine syndrome classification system based on deep learning and feature decoupling. Through the displayed feature decoupling and adversarial training mechanism, the deep neural network is forced to simulate the focus in the traditional Chinese medicine syndrome differentiation process, and accurate classification of the chronic skin disease syndrome types is achieved; comprising a shared feature encoder, a color feature decoupling head, a texture feature decoupling head, a color auxiliary discriminator, a texture auxiliary discriminator, a trunk feature extractor and a comprehensive classifier. According to the method, the defect of black box of the existing deep learning model is overcome, and an interpretable diagnosis basis conforming to the traditional Chinese medicine syndrome differentiation logic is provided. Test results show that the method can still keep high accuracy and strong generalization ability under the condition of few training samples, and the application potential of the method in the field of artificial intelligence assisted traditional Chinese medicine diagnosis is shown.